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https://www.readbyqxmd.com/read/27933284/-we-sometimes-hold-on-to-ours-professionals-views-on-factors-that-both-delay-and-facilitate-transition-to-adult-care
#1
Susie Aldiss, Hilary Cass, Judith Ellis, Faith Gibson
BACKGROUND: The transition from child to adult services is a crucial time in the health of young people who may potentially fall into a poorly managed "care gap." Health service provision, which fails to meet the needs of young people and families at this time of significant change, may result in deterioration in health or disengagement with services, which can have negative long-term consequences. Developing transitional care packages has become a focus of activity in the United Kingdom and elsewhere...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27933271/functional-significance-of-aurora-kinases-p53-protein-family-interactions-in-cancer
#2
REVIEW
Kaori Sasai, Warapen Treekitkarnmongkol, Kazuharu Kai, Hiroshi Katayama, Subrata Sen
Aurora kinases play critical roles in regulating spindle assembly, chromosome segregation, and cytokinesis to ensure faithful segregation of chromosomes during mitotic cell division cycle. Molecular and cell biological studies have revealed that Aurora kinases, at physiological levels, orchestrate complex sequential cellular processes at distinct subcellular locations through functional interactions with its various substrates. Aberrant expression of Aurora kinases, on the other hand, cause defects in mitotic spindle assembly, checkpoint response activation, and chromosome segregation leading to chromosomal instability...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27933035/life-without-dutpase
#3
Csaba Kerepesi, Judit E Szabó, Veronika Papp-Kádár, Orsolya Dobay, Dóra Szabó, Vince Grolmusz, Beáta G Vértessy
Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of Deoxyribonucleic Acid (DNA). The genetic information is also safeguarded by DNA damage recognition and repair processes. Uracil is one of the most frequently occurring erroneous bases in DNA; it can arise from cytosine deamination or thymine-replacing incorporation. Two enzyme activities are primarily involved in keeping DNA uracil-free: dUTPase (dUTP pyrophosphatase) activity that prevent thymine-replacing incorporation and uracil-DNA glycosylase activity that excise uracil from DNA and initiate uracil-excision repair...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27930512/religious-stigmata-as-malingering-artifact-report-of-a-case-and-review-of-the-literature
#4
Domenico Bonamonte, Michelangelo Vestita, Angela Filoni, Giuseppe Giudice, Gianni Angelini
RATIONALE: Artifacts or simulated diseases are self-inflicted conditions caused by various means and for different purposes. Disease simulation can be motivated, among other things, by illegal purposes, to escape from civil duties or prison sentences, for example, or to exploit specific situations in order to receive a range of benefits. In such cases, the simulator is fully aware of his or her actions and intentions. DIAGNOSES, INTERVENTIONS AND OUTCOMES: We report the case of a 42-year-old woman who, for 3 consecutive years, showed religious stigmata on the forehead and on the dorsal surface of hands and feet immediately before Easter...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930399/practical-discourse-revisited-hermeneutics-at-the-intersection-of-philosophy-and-nursing
#5
Stephen M Padgett
Three early papers by Janice Thompson-Practical Discourse, Critical Scholarship, and Hermeneutic Inquiry-are examined in reference to the historical context of the time (1985-1990), and implications for current scholarship. Hermeneutic philosophy has been neglected in recent years, overshadowed by its weaker cousin phenomenology. I argue that renewed attention to hermeneutics would help us focus on the "situatedness" of nursing scholars, the class politics of academia, and a better balance in interpretative work between faith and suspicion...
December 6, 2016: ANS. Advances in Nursing Science
https://www.readbyqxmd.com/read/27929612/effects-of-cumulative-herpesviridae-and-toxoplasma-gondii-infections-on-cognitive-function-in-healthy-bipolar-and-schizophrenia-subjects
#6
Nora Hamdani, Claire Daban-Huard, Ophelia Godin, Hakim Laouamri, Stéphane Jamain, Dodji Attiba, Marine Delavest, Jean-Pierre Lépine, Philippe Le Corvoisier, Josselin Houenou, Jean-Romain Richard, Robert H Yolken, Rajagopal Krishnamoorthy, Ryad Tamouza, Marion Leboyer, Faith B Dickerson
OBJECTIVE: Schizophrenia and bipolar disorder are associated with cognitive impairment leading to social disruption. While previous studies have focused on the effect of individual infectious exposure, namely, Herpesviridae viruses or Toxoplasma gondii (T gondii), on cognitive functioning, the objective of the present study was to examine the effect of multiple infections on cognitive functioning in patients with schizophrenia and bipolar disorder and in healthy controls. METHODS: Seropositivity to herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), cytomegalovirus (CMV), and T gondii was related to cognitive status among 423 participants (recruited between 2008 and 2014; 138 patients with bipolar disorder, 105 patients with schizophrenia [DSM-IV criteria], and 180 healthy controls) for episodic verbal memory (California Verbal Learning Test), working memory (Wechsler Adult Intelligence Scale, third edition), and premorbid intelligence quotient (National Adult Reading Test)...
December 6, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27929471/isolation-and-expansion-of-adult-canine-hippocampal-neural-precursors
#7
Thomas Duncan, Aileen Lowe, Marshall A Dalton, Michael Valenzuela
The rate of neurogenesis within the adult hippocampus has been shown to vary across mammalian species. The canine hippocampus, demonstrating a structural intermediacy between the rodent and human hippocampi, is therefore a valuable model in which to study adult neurogenesis. In vitro culture assays are an essential component of characterizing neurogenesis and adult neural precursor cells, allowing for precise control over the cellular environment. To date however, culture protocols for canine cells remain under-represented in the literature...
November 29, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27928403/increased-prevalence-of-optic-disc-drusen-after-papilloedema-from-idiopathic-intracranial-hypertension-on-the-possible-formation-of-optic-disc-drusen
#8
Faith A Birnbaum, Gabriella M Johnson, Lenworth N Johnson, Bokkwan Jun, Jason T Machan
This is a 25-year observational retrospective review of 372 consecutive participants with optic disc drusen or resolved papilloedema from idiopathic intracranial hypertension. The prevalence of optic disc drusen at 19% among eyes with resolved papilloedema was approximately 10 times higher and significantly increased (p < 0.001) as compared with the occurrence in the general population. Eyes with both resolved papilloedema and optic disc drusen had similar visual acuity and visual field outcome as compared with resolved papilloedema alone...
August 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27927217/an-assessment-of-the-effect-of-user-fee-policy-reform-on-facility-based-deliveries-in-rural-zambia
#9
Chitalu Miriam Chama-Chiliba, Steven Fredric Koch
BACKGROUND: Improving maternal health outcomes by reducing barriers to accessing maternal health services is a key goal for most developing countries. This paper analyses the effect of user fee removal, which was announced for rural areas of Zambia in April 2006, on the use of public health facilities for childbirth. METHODS: Data from the 2007 Zambia Demographic and Health Survey, including birth histories for the five years preceding the survey, is linked to administrative data and geo-referenced health facility census data...
December 7, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27926879/in%C3%A2-vitro-derivation-and-propagation-of-spermatogonial-stem-cell-activity-from-mouse-pluripotent-stem-cells
#10
Yukiko Ishikura, Yukihiro Yabuta, Hiroshi Ohta, Katsuhiko Hayashi, Tomonori Nakamura, Ikuhiro Okamoto, Takuya Yamamoto, Kazuki Kurimoto, Kenjiro Shirane, Hiroyuki Sasaki, Mitinori Saitou
The in vitro derivation and propagation of spermatogonial stem cells (SSCs) from pluripotent stem cells (PSCs) is a key goal in reproductive science. We show here that when aggregated with embryonic testicular somatic cells (reconstituted testes), primordial germ cell-like cells (PGCLCs) induced from mouse embryonic stem cells differentiate into spermatogonia-like cells in vitro and are expandable as cells that resemble germline stem cells (GSCs), a primary cell line with SSC activity. Remarkably, GSC-like cells (GSCLCs), but not PGCLCs, colonize adult testes and, albeit less effectively than GSCs, contribute to spermatogenesis and fertile offspring...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27925076/experience-and-coping-strategies-in-relatives-of-addicts
#11
Ana Lucia de Moraes Horta, Celina Daspett, Julia Horta Tabosa do Egito, Rosa Maria Stefanini de Macedo
Objective: to understand the experience and coping strategies in relatives of drug addicts. Method: a study was developed with 87 relatives of addicts, registered in two Basic Health Units. The focus group was used as the study method, and content analysis was applied. Results: four categories were chosen: perception of relatives about the drug addiction of their family members; feelings and attitudes related to being a relative of an addict; difficulties found in the process; and, coping strategies...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27924353/-the-old-man-and-the-i-sea-u-essay-on-faith-fate-and-evidence-after-the-manner-of-hemingway
#12
K Lewandowski, R H Bartlett
Robert Bartlett, emeritus Professor of surgery at the University of Michigan in Ann Arbor, USA, transformed classical works of world literature (Charles Dickens: A Christmas Carol, Lewis Carroll: Alice in Wonderland) into teaching aids for advanced training in intensive care medicine. He recently turned his hand to the well-known work of Ernest Hemingway: the Nobel Prize winning novel The Old Man and the Sea. Subsequent to Robert Bartlett's essay this article provides background information and comments on the current problems in modern intensive care medicine addressed in his essay...
December 6, 2016: Der Anaesthesist
https://www.readbyqxmd.com/read/27923966/thinking-style-as-a-predictor-of-men-s-participation-in-cancer-screening
#13
Clare E McGuiness, Deborah Turnbull, Carlene Wilson, Amy Duncan, Ingrid H Flight, Ian Zajac
Men's participation in cancer screening may be influenced by their thinking style. Men's need for cognition (NFC) and faith in intuition were measured to explore whether they varied by demographic variables or predicted screening behavior. Australian males (n = 585, aged 50-74 years) completed surveys about past screening and were subsequently offered mailed fecal occult blood tests (FOBTs). Demographic predictors included age, socioeconomic status, educational attainment, and language spoken at home. The screening behaviors were self-reported prostate cancer screening (prostate-specific antigen testing and digital rectal examinations [DREs]), and colorectal cancer screening (self-reported FOBT participation and recorded uptake of the FOBT offer)...
December 5, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27923136/chromosome-segregation-reconstituting-the-kinetochore
#14
Frederick G Westhorpe, Aaron F Straight
Faithful chromosome segregation is accomplished by attachment of chromosomes to spindle microtubules using the kinetochore. In a major step forward in understanding the functional and structural complexity of kinetochores, a 21-subunit human centromere - kinetochore complex has been reconstituted entirely from purified components, recreating the connection between DNA and microtubule.
December 5, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27923063/control-of-gene-expression-by-rna-binding-protein-action-on-alternative-translation-initiation-sites
#15
Angela Re, Levi Waldron, Alessandro Quattrone
Transcript levels do not faithfully predict protein levels, due to post-transcriptional regulation of gene expression mediated by RNA binding proteins (RBPs) and non-coding RNAs. We developed a multivariate linear regression model integrating RBP levels and predicted RBP-mRNA regulatory interactions from matched transcript and protein datasets. RBPs significantly improved the accuracy in predicting protein abundance of a portion of the total modeled mRNAs in three panels of tissues and cells and for different methods employed in the detection of mRNA and protein...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27922580/comparative-analysis-of-peri-operative-outcomes-using-nationally-derived-hospital-discharge-data-relative-to-a-prospective-multi-center-surgical-database-of-adult-spinal-deformity-surgery
#16
Gregory W Poorman, Peter G Passias, Aaron J Buckland, Cyrus M Jalai, Michael Kelly, Daniel M Sciubba, Brian J Neuman, D Kojo Hamilton, Amit Jain, Bassel Diebo, Virginie Lafage, Shay Bess, Eric O Klineberg
STUDY DESIGN: Retrospective analysis of three prospectively collected databases. OBJECTIVE: compare peri-operative outcomes in Adult Spinal Deformity (ASD) surgeries in a surgeon-run (SR-ASD) and two national databases: the Nationwide Inpatient Sample (NIS) and the National Surgical Quality Improvement Program (NSQIP). SUMMARY OF BACKGROUND DATA: has been learned on the treatment of ASD in the last decade with prospective multicenter collaborative research focusing on this specific condition...
December 2, 2016: Spine
https://www.readbyqxmd.com/read/27922474/embracing-a-nurse-driven-alcohol-withdrawal-protocol-through-quality-improvement
#17
John Barrett, Maria Jansen, April Cooper, Matthew Felbinger, Faith Waters
BACKGROUND: Alcohol withdrawal can lead to severe complications including seizures, delirium tremens, and death if not treated appropriately. Nurses are critical to the safety and outcomes of these patients. OBJECTIVE: The objective of this retrospective study was to determine if nursing education on a community hospital's alcohol withdrawal protocol led to improved nursing compliance. METHODS: This is a quality improvement project involving a two-part retrospective review-an initial needs assessment followed by nursing education and a subsequent posteducation retrospective review...
October 2016: Journal of Addictions Nursing
https://www.readbyqxmd.com/read/27919712/extracts-from-two-ubiquitous-mediterranean-plants-ameliorate-cellular-and-animal-models-of-neurodegenerative-proteinopathies
#18
Michelle Briffa, Stephanie Ghio, Johanna Neuner, Alison J Gauci, Rebecca Cacciottolo, Christelle Marchal, Mario Caruana, Christophe Cullin, Neville Vassallo, Ruben J Cauchi
A signature feature of age-related neurodegenerative proteinopathies is the misfolding and aggregation of proteins, typically amyloid-β (Aβ) in Alzheimer's disease (AD) and α-synuclein (α-syn) in Parkinson's disease (PD), into soluble oligomeric structures that are highly neurotoxic. Cellular and animal models that faithfully replicate the hallmark features of these disorders are being increasing exploited to identify disease-modifying compounds. Natural compounds have been identified as a useful source of bioactive molecules with promising neuroprotective capabilities...
December 2, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27919483/a-systematic-review-of-anxiety-amongst-people-with-multiple-sclerosis
#19
REVIEW
Ellen Butler, Faith Matcham, Trudie Chalder
BACKGROUND: Multiple Sclerosis (MS) is a chronic neurological disease, which poses significant psychological challenges. The purpose of this systematic review was to identify factors that are associated with anxiety in people with MS (PwMS). It aimed to examine the strength of evidence for factors associated with anxiety symptoms and identify limitations of existing studies. METHOD AND RESULTS: One hundred and thirty one studies met inclusion criteria and were included in the review...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27918562/resting-state-connectivity-biomarkers-define-neurophysiological-subtypes-of-depression
#20
Andrew T Drysdale, Logan Grosenick, Jonathan Downar, Katharine Dunlop, Farrokh Mansouri, Yue Meng, Robert N Fetcho, Benjamin Zebley, Desmond J Oathes, Amit Etkin, Alan F Schatzberg, Keith Sudheimer, Jennifer Keller, Helen S Mayberg, Faith M Gunning, George S Alexopoulos, Michael D Fox, Alvaro Pascual-Leone, Henning U Voss, B J Casey, Marc J Dubin, Conor Liston
Biomarkers have transformed modern medicine but remain largely elusive in psychiatry, partly because there is a weak correspondence between diagnostic labels and their neurobiological substrates. Like to other neuropsychiatric disorders, depression is not a unitary disease, but rather a heterogeneous syndrome that encompasses varied, co-occurring symptoms and divergent responses to treatment. By using functional magnetic resonance imaging (fMRI) in a large multisite sample (n = 1,188), we show here that patients with depression can be subdivided into four neurophysiological subtypes ('biotypes') defined by distinct patterns of dysfunctional connectivity in limbic and frontostriatal networks...
December 5, 2016: Nature Medicine
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