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https://www.readbyqxmd.com/read/29777898/a-survey-of-health-professionals-views-on-acceptable-gestational-age-and-termination-of-pregnancy-for-fetal-anomaly
#1
Lisa Crowe, Ruth H Graham, Stephen C Robson, Judith Rankin
Termination of pregnancy for fetal anomaly is legal in the UK with no upper limit, if two doctors, in good faith, agree "there is a substantial risk that if the child were born it would suffer from such physical or mental abnormalities as to be seriously handicapped". This is Clause E of the Human Fertlisation and Embryology Act. The most commonly sighted Clause is C, which states "the pregnancy has not exceeded its twenty-fourth week and that the continuance of the pregnancy would involve risk, greater than if the pregnancy were terminated, of injury to the physical or mental health of the pregnant woman"...
May 16, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29777643/infertility-psychological-distress-and-coping-strategies-among-women-in-mali-west-africa-a-mixed-methods-study
#2
Rosanna F Hess, Ratchneewan Ross, John L GilillandJr
Relatively little is known about infertility and its consequences in Mali, West Africa where the context and culture are different from those of previously studied settings. This study therefore aimed to specifically examine infertility induced psychological distress and coping strategies among women in Mali. A convergent mixed-methods design-correlational cross-sectional and qualitative descriptive-guided the study. Fifty-eight infertile Malian women participated: 52 completed the Psychological Evaluation Test specific for infertility and a question on general health status, and 26 were interviewed in-depth...
March 2018: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29776091/modeling-persistence-of-motion-in-a-crowded-environment-the-diffusive-limit-of-excluding-velocity-jump-processes
#3
Enrico Gavagnin, Christian A Yates
Persistence of motion is the tendency of an object to maintain motion in a direction for short time scales without necessarily being biased in any direction in the long term. One of the most appropriate mathematical tools to study this behavior is an agent-based velocity-jump process. In the absence of agent-agent interaction, the mean-field continuum limit of the agent-based model (ABM) gives rise to the well known hyperbolic telegraph equation. When agent-agent interaction is included in the ABM, a strictly advective system of partial differential equations (PDEs) can be derived at the population level...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29773497/indications-for-red-cell-transfusions-in-pediatric-patients
#4
REVIEW
Jill M Cholette, Suzie A Noronha, Jerard Seghatchian, Neil Blumberg
Red cell transfusions are amongst the most common therapeutic procedures in seriously ill children, particularly in the inpatient setting. This is despite the fact that there is no evidence base for most clinical settings, with the exception of patients with hemoglobinopathies, particularly thalassemia and sickle cell anemia. Obviously exsanguinating hemorrhage and life threatening anemia are urgent indications for which no other therapeutic approach is currently available. Most transfusions are, however, given prophylactically to prevent the complications of hypoxia or hemodynamic stability, based upon expert opinion and a faith in the oxygen carrying capacity and beneficial hemodynamic properties of transfused red cells...
May 10, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29772476/fate-of-nuclear-material-during-subsequent-steps-of-the-kinetin-induced-pcd-in-apical-parts-of-vicia-faba-ssp-minor-seedling-roots
#5
Andrzej Kaźmierczak, Kamila Soboska
In animals during apoptosis, the best examined type of programmed cell death (PCD), three main phases are distinguished: (i) specification (signaling), (ii) killing and (iii) execution one. It has bean postulated that plant PCD also involves three subsequent phases: (i) transmission of death signals to cells (signaling), (ii) initiation of killing processes and (iii) destruction of cells. One of the most important hallmarks of animal and plant PCD are those regarding nucleus, not thoroughly studied in plants so far...
April 30, 2018: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29771379/cdk-phosphorylation-licenses-kif4a-chromosome-localization-required-for-early-mitotic-progression
#6
Zhixiong Dong, Changjun Zhu, Qimin Zhan, Wei Jiang
The chromokinesin Kif4A controls proper chromosome condensation, congression/alignment, and cytokinesis to ensure faithful genetic inheritance. Here, we report that Cdk phosphorylation of human Kif4A at T1161 licenses Kif4A chromosomal localization, which, in turn, controls Kif4A early mitotic function. Phosphorylated Kif4A (Kif4AWT) or Cdk phospho-mimetic Kif4A mutant (Kif4ATE) associated with chromosomes and condensin I (non-SMC subunit CAP-G and core subunit SMC2) to regulate chromosome condensation, spindle morphology, and chromosome congression/alignment in early mitosis...
May 16, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29767526/the-role-of-solute-attractive-forces-in-the-atomic-scale-theory-of-hydrophobic-effects
#7
Ang Gao, Liang Tan, Lawrence R Pratt, Mangesh I Chaudhari, Susan B Rempe, Dilipkumar Asthagiri, John D Weeks
The role that van der Waals (vdW) attractive forces play in the hydration and association of atomic hydrophobic solutes like argon (Ar) in water is reanalyzed using the local molecular field (LMF) theory of those interactions. In this problem, solute vdW attractive forces can reduce or mask hydrophobic interactions as measured by contact peak heights of the ArAr correlation function compared to reference results for purely repulsive core solutes. Nevertheless, both systems exhibit characteristic hydrophobic inverse temperature behavior in which hydrophobic association become stronger with increasing temperature through a moderate temperature range...
May 16, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29765651/surrogate-modelling-for-the-prediction-of-spatial-fields-based-on-simultaneous-dimensionality-reduction-of-high-dimensional-input-output-spaces
#8
D Crevillén-García
Time-consuming numerical simulators for solving groundwater flow and dissolution models of physico-chemical processes in deep aquifers normally require some of the model inputs to be defined in high-dimensional spaces in order to return realistic results. Sometimes, the outputs of interest are spatial fields leading to high-dimensional output spaces. Although Gaussian process emulation has been satisfactorily used for computing faithful and inexpensive approximations of complex simulators, these have been mostly applied to problems defined in low-dimensional input spaces...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29764989/global-assessment-of-its-network-dynamics-reveals-that-the-kinase-plk1-inhibits-the-phosphatase-pp6-to-promote-aurora-a-activity
#9
Arminja N Kettenbach, Kate A Schlosser, Scott P Lyons, Isha Nasa, Jiang Gui, Mark E Adamo, Scott A Gerber
Polo-like kinase 1 (Plk1) is an essential protein kinase that promotes faithful mitotic progression in eukaryotes. The subcellular localization and substrate interactions of Plk1 are tightly controlled and require its binding to phosphorylated residues. To identify phosphorylation-dependent interactions within the Plk1 network in human mitotic cells, we performed quantitative proteomics on HeLa cells cultured with kinase inhibitors or expressing a Plk1 mutant that was deficient in phosphorylation-dependent substrate binding...
May 15, 2018: Science Signaling
https://www.readbyqxmd.com/read/29764294/impact-of-muslim-opinion-leaders-training-of-healthcare-providers-on-the-uptake-of-mnch-services-in-northern-nigeria
#10
Judith-Ann Walker, Yahaya Hashim, Nelson Oranye
Expanding access to maternal, newborn and child health (MNCH) services in traditional societies is a public health challenge, often complicated by cultural and religious beliefs about what is permitted or not permitted within a faith group. This is particularly true in the Muslim majority North of Nigeria, where deep suspicions of Western public health programmes, coupled with failing and underfunded health system, have led to the emergence of a new generation of Muslim Opinion Leaders (MOLs) with counter-narratives against family planning, immunisation and nutrition programmes...
May 15, 2018: Global Public Health
https://www.readbyqxmd.com/read/29761753/against-the-stream-religion-and-mental-health-the-case-for-the-inclusion-of-religion-and-spirituality-into-psychiatric-care
#11
Simon Dein
This paper argues for the inclusion of religion and spirituality in psychiatric care. After discussing the antagonism of psychiatrists and psychologists to religion, I present a critical overview of studies examining the relationships between spirituality, religion and diverse aspects of mental health: depression, suicide, anxiety, delinquency, drug abuse and schizophrenia. The need to assesses the impact of religion in different faith groups is discussed. Measures of religious coping, both positive and negative, may provide a more accurate portrayal as to how individuals deploy religion in their lives than global measures such as belief and attendance...
June 2018: BJPsych Bulletin
https://www.readbyqxmd.com/read/29760694/dissemination-of-orientia-tsutsugamushi-a-causative-agent-of-scrub-typhus-and-immunological-responses-in-the-humanized-draga-mouse
#12
Le Jiang, Erin K Morris, Rodrigo Aguilera-Olvera, Zhiwen Zhang, Teik-Chye Chan, Soumya Shashikumar, Chien-Chung Chao, Sofia A Casares, Wei-Mei Ching
Scrub typhus is caused by Orientia tsutsugamushi , an obligated intracellular bacterium that affects over one million people per year. Several mouse models have been used to study its pathogenesis, disease immunology, and for testing vaccine candidates. However, due to the intrinsic differences between the immune systems in mouse and human, these mouse models could not faithfully mimic the pathology and immunological responses developed by human patients, limiting their value in both basic and translational studies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29760061/methylglucosylation-of-aromatic-amino-and-phenolic-moieties-of-drug-like-biosynthons-by-combinatorial-biosynthesis
#13
Linan Xie, Liwen Zhang, Chen Wang, Xiaojing Wang, Ya-Ming Xu, Hefen Yu, Ping Wu, Shenglan Li, Lida Han, A A Leslie Gunatilaka, Xiaoyi Wei, Min Lin, István Molnár, Yuquan Xu
Glycosylation is a prominent strategy to optimize the pharmacokinetic and pharmacodynamic properties of drug-like small-molecule scaffolds by modulating their solubility, stability, bioavailability, and bioactivity. Glycosyltransferases applicable for "sugarcoating" various small-molecule acceptors have been isolated and characterized from plants and bacteria, but remained cryptic from filamentous fungi until recently, despite the frequent use of some fungi for whole-cell biocatalytic glycosylations...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29759151/circulating-tumour-dna-for-detecting-minimal-residual-disease-in-multiple-myeloma
#14
REVIEW
Trevor J Pugh
Circulating tumor DNA faithfully recapitulates somatic mutations detected in bone marrow aspirates from patients with newly diagnosed or relapsed or recurrent myeloma. Extending these methods to enable detection of minimal residual disease will require increased sensitivity and breadth of genomic assays to maximize information content from small quantities of cell-free DNA; as well as definition of a clinically meaningful ctDNA concentration in comparison with conventional bone marrow cell-count thresholds...
January 2018: Seminars in Hematology
https://www.readbyqxmd.com/read/29758701/slow-relaxation-dynamics-of-clogs-in-a-vibrated-granular-silo
#15
B V Guerrero, L A Pugnaloni, C Lozano, I Zuriguel, A Garcimartín
We experimentally explore the vibration-induced unclogging of arches halting the flow in a two-dimensional silo. The endurance of arches is determined by carrying out a survival analysis of their breaking times. By analyzing the dynamics of two morphological variables, we demonstrate that arches evolve toward less regular structures and it seems that there may exist a certain degree of irregularity that the arch reaches before collapsing. Moreover, we put forward that σ (the standard deviation of all angles between consecutive beads) describes faithfully the morphological evolution of the arch...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29758442/enhancing-knowledge-and-skills-through-the-delivery-of-a-bespoke-neonatal-resuscitation-training-programme-in-a-developing-country
#16
Faith Cm Kayembe Née Manyema, Jacqueline Wier
No abstract text is available yet for this article.
April 26, 2018: Midwifery
https://www.readbyqxmd.com/read/29757941/exploring-how-the-home-environment-influences-eating-and-physical-activity-habits-of-low-income-latino-children-of-predominantly-immigrant-families-a-qualitative-study
#17
Ana Cristina Lindsay, Sherrie F Wallington, Faith D Lees, Mary L Greaney
Latinos are the largest and fastest growing minority population group in the United States, and children in low-income Latino families are at elevated risk of becoming overweight or having obesity. A child’s home is an important social environment in which he/she develops and maintains dietary and physical activity (PA) habits that ultimately impact weight status. Previous research suggests the parents are central to creating a home environment that facilitates or hinders the development of children’s early healthy eating and PA habits...
May 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29755732/recent-advances-in-understanding-oogenesis-interactions-with-the-cytoskeleton-microtubule-organization-and-meiotic-spindle-assembly-in-oocytes
#18
REVIEW
Florence L Marlow
Maternal control of development begins with production of the oocyte during oogenesis. All of the factors necessary to complete oocyte maturation, meiosis, fertilization, and early development are produced in the transcriptionally active early oocyte. Active transcription of the maternal genome is a mechanism to ensure that the oocyte and development of the early embryo begin with all of the factors needed for successful embryonic development. To achieve the maximum maternal store, only one functional cell is produced from the meiotic divisions that produce the oocyte...
2018: F1000Research
https://www.readbyqxmd.com/read/29754110/ghanaian-traditional-and-faith-healers-explanatory-models-for-epilepsy
#19
Lily Kpobi, Leslie Swartz, Mpoe Johannah Keikelame
Epilepsy is the most common neurological condition in sub-Saharan Africa. A significant number of people with epilepsy in low- and middle-income countries do not receive formal biomedical care. They utilize the services of various traditional and alternative medicine practitioners. However, there is relatively little information about the beliefs and methods of alternative healthcare providers about epilepsy in many African countries. Using explanatory models of illness framework, we interviewed thirty-six traditional and faith healers in Ghana on their beliefs and perceptions about epilepsy, as well as how they would treat epilepsy...
May 10, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29751313/occurrence-fate-and-removal-of-pharmaceuticals-personal-care-products-and-pesticides-in-wastewater-stabilization-ponds-and-receiving-rivers-in-the-nzoia-basin-kenya
#20
Kenneth Otieno K'oreje, Faith Jebiwot Kandie, Leendert Vergeynst, Margaret Akinyi Abira, Herman Van Langenhove, Maurice Okoth, Kristof Demeestere
Although there is increased global environmental concern about emerging organic micropollutants (EOMPs) such as pharmaceuticals, personal care products (PPCPs) and polar pesticides, limited information is available on their occurrence in Africa. This study presents unique data on concentrations and loads of 31 PPCPs and 10 pesticides in four wastewater stabilization ponds (WSPs) and receiving rivers (flowing through urban centres) in Kenya. The WSPs indicate a high potential to remove pharmaceutically active compounds (PhACs) with removals by up to >4 orders of magnitude (>99...
May 8, 2018: Science of the Total Environment
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