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https://www.readbyqxmd.com/read/29352269/phosphorylation-by-protein-kinase-a-disassembles-the-caspase-9-core
#1
Banyuhay P Serrano, Jeanne A Hardy
Caspases, the cysteine proteases which facilitate the faithful execution of apoptosis, are tightly regulated by a number of mechanisms including phosphorylation. In response to cAMP, PKA phosphorylates caspase-9 at three sites preventing caspase-9 activation, and suppressing apoptosis progression. Phosphorylation of caspase-9 by PKA at the functionally relevant site Ser-183 acts as an upstream block of the apoptotic cascade, directly inactivating caspase-9 by a two-stage mechanism. First, Ser-183 phosphorylation prevents caspase-9 self-processing and directly blocks substrate binding...
January 19, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29351963/the-exon-junction-complex-structural-insights-into-a-faithful-companion-of-mammalian-mrnps
#2
REVIEW
Jennifer V Gerbracht, Niels H Gehring
During splicing, the exon junction complex (EJC) is deposited upstream of exon-exon boundaries. The EJC and its peripheral bound proteins play an essential role in mediating mRNA export, translation and turnover. However, the exact sequence of EJC assembly and the involved factors during splicing remain elusive. Recently published structures of the human C* spliceosome clarified the position of the EJC at this phase of splicing and have given insight into previously unidentified interactions between the EJC and spliceosomal proteins...
January 19, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29351650/are-evidence-based-community-engaged-energy-balance-interventions-enough-for-extremely-vulnerable-populations
#3
Nancy E Schoenberg, Yelena N Tarasenko, Claire Snell-Rood
Well-documented associations between lifestyle behaviors and disease outcomes necessitate evidence-based health promotion interventions. To enhance potential efficacy and effectiveness, interventionists increasingly respond to community priorities, employ comprehensive theoretical frameworks, invest heavily to ensure cultural fit, implement evidence-based programming, and deploy research gold standards. We describe a project that followed all of these recommended strategies, but did not achieve desired outcomes...
January 17, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29351298/construction-of-an-infectious-horsepox-virus-vaccine-from-chemically-synthesized-dna-fragments
#4
Ryan S Noyce, Seth Lederman, David H Evans
Edward Jenner and his contemporaries believed that his variolae vaccinae originated in horses and molecular analyses show that modern vaccinia virus (VACV) strains share common ancestry with horsepox virus (HPXV). Given concerns relating to the toxicity of modern VACV vaccines, we asked whether an HPXV-based vaccine might provide a superior alternative. Since HPXV may be extinct and the only specimen of HPXV that has been identified is unavailable for investigation, we explored whether HPXV could be obtained by large-scale gene synthesis...
2018: PloS One
https://www.readbyqxmd.com/read/29350951/high-fidelity-preservation-of-quantum-information-during-trapped-ion-transport
#5
Peter Kaufmann, Timm F Gloger, Delia Kaufmann, Michael Johanning, Christof Wunderlich
A promising scheme for building scalable quantum simulators and computers is the synthesis of a scalable system using interconnected subsystems. A prerequisite for this approach is the ability to faithfully transfer quantum information between subsystems. With trapped atomic ions, this can be realized by transporting ions with quantum information encoded into their internal states. Here, we measure with high precision the fidelity of quantum information encoded into hyperfine states of a ^{171}Yb^{+} ion during ion transport in a microstructured Paul trap...
January 5, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29349357/comprehensive-cytotoxicity-studies-of-superparamagnetic-iron-oxide-nanoparticles
#6
REVIEW
Rakesh M Patil, Nanasaheb D Thorat, Prajkta B Shete, Poonam A Bedge, Shambala Gavde, Meghnad G Joshi, Syed A M Tofail, Raghvendra A Bohara
Recently lots of efforts have been taken to develop superparamagnetic iron oxide nanoparticles (SPIONs) for biomedical applications. So it is utmost necessary to have in depth knowledge of the toxicity occurred by this material. This article is designed in such way that it covers all the associated toxicity issues of SPIONs. It mainly emphasis on toxicity occurred at different levels including cellular alterations in the form of damage to nucleic acids due to oxidative stress and altered cellular response. In addition focus is been devoted for in vitro and in vivo toxicity of SPIONs, so that a better therapeutics can be designed...
March 2018: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29349351/the-relationship-between-subjective-oral-health-and-dental-fear-in-korean-adolescents
#7
Young-Soon Won, Youn-Soo Shim, So-Youn An
Background: This study is aimed to evaluate the level of fear and to reduce the overall fear, thereby enabling patients to receive treatment via timely visits. Methods: In a survey conducted by 460 South Korean middle school students, we used 453 data that faithfully responded to the survey. Multiple regression analysis was conducted to investigate the factors influencing subjective oral health and dental fear. The significance level used for statistical significance was α = 0...
December 2017: Journal of Dental Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29348326/symmetry-from-asymmetry-or-asymmetry-from-symmetry
#8
Elizabeth W Kahney, Rajesh Ranjan, Ryan J Gleason, Xin Chen
The processes of DNA replication and mitosis allow the genetic information of a cell to be copied and transferred reliably to its daughter cells. However, if DNA replication and cell division were always performed in a symmetric manner, the result would be a cluster of tumor cells instead of a multicellular organism. Therefore, gaining a complete understanding of any complex living organism depends on learning how cells become different while faithfully maintaining the same genetic material. It is well recognized that the distinct epigenetic information contained in each cell type defines its unique gene expression program...
January 18, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29347972/extending-the-utility-of-the-who-recommended-assay-for-direct-detection-of-enteroviruses-from-clinical-specimen-for-resolving-poliovirus-co-infection
#9
Temitope Oluwasegun Cephas Faleye, Moses Olubusuyi Adewumi, Naomi Princess Ozegbe, Oluwaseun Elijah Ogunsakin, Grace Ariyo, Faith Wuraola Adeshina, Oluwaseun Sarah Ogunga, Similoluwa Deborah Oluwadare, Johnson Adekunle Adeniji
OBJECTIVES: In a polio-free world there might be reduced funding for poliovirus surveillance. There is therefore the need to ensure that enterovirologist globally, especially those outside the global polio laboratory network, can participate in poliovirus surveillance without neglecting their enterovirus type of interest. To accomplish this, assays are needed that allow such active participation. RESULTS: In this study we describes a sensitive and specific utility extension of the recently recommended WHO RT-snPCR assay that enables independent detection of the three poliovirus types especially in cases of co-infection...
January 18, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29345626/accelerating-acquisition-strategies-for-low-frequency-conductivity-imaging-using-mreit
#10
Yizhuang Song, Jin Keun Seo, Munish Chauhan, Aprinda Indahlastari, Neeta Ashok Kumar, Rosalind Sadleir
We sought to improve efficiency of Magnetic Resonance Electrical Impedance Tomography data acquisition so that fast conductivity changes or electric field variations could be monitored. Undersampling of k-space was used to decrease acquisition times in spin-echo-based sequences by a factor of two. Full MREIT data were reconstructed using continuity assumptions and preliminary scans gathered without current. We found that phase data were reconstructed faithfully from undersampled data. Conductivity reconstructions of phantom data were also possible...
January 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29345014/human-induced-pluripotent-stem-cell-models-of-retinitis-pigmentosa
#11
REVIEW
Ana Artero Castro, Dunja Lukovic, Pavla Jendelova, Slaven Erceg
Hereditary retinal dystrophies, specifically retinitis pigmentosa (RP) are clinically and genetically heterogeneous diseases affecting primarily retinal cells and retinal pigment epithelial (RPE) cells with blindness as a final outcome. Understanding the pathogenicity behind these diseases has been largely precluded by the unavailability of affected tissue from patients, large genetic heterogeneity and animal models that do not faithfully represent some human diseases. A landmark discovery of human induced pluripotent stem cells (hiPSC) permitted the derivation of patient-specific cells...
January 18, 2018: Stem Cells
https://www.readbyqxmd.com/read/29344686/executive-control-and-faithfulness-only-long-term-romantic-relationships-require-prefrontal-control
#12
Ryuhei Ueda, Kuniaki Yanagisawa, Hiroshi Ashida, Nobuhito Abe
Individuals in the early stages of a romantic relationship generally express intense passionate love toward their partners. This observation allows us to hypothesize that the regulation of interest in extra-pair relationships by executive control, which is supported by the function of the prefrontal cortex, is less required in individuals in the early stages of a relationship than it is in those who are in a long-term relationship. To test this hypothesis, we asked male participants in romantic relationships to perform a go/no-go task during functional magnetic resonance imaging (fMRI), which is a well-validated task that can measure right ventrolateral prefrontal cortex (VLPFC) activity implicated in executive control...
January 17, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29340269/examining-relationships-between-perceptions-and-objective-assessments-of-neighborhood-environment-and-sedentary-time-data-from-the-washington-d-c-cardiovascular-health-and-needs-assessment
#13
Chaarushi Ahuja, Colby Ayers, Jacob Hartz, Joel Adu-Brimpong, Samantha Thomas, Valerie Mitchell, Marlene Peters-Lawrence, Dana Sampson, Alyssa T Brooks, Gwenyth Wallen, Allan Johnson, Lennox Graham, Avis Graham, Joshua Rivers, Leah Yingling, Tiffany M Powell-Wiley
Sedentary time (ST) and neighborhood environment (NE) are predictors of cardiovascular (CV) health. However, little is known about ST's relationship with NE. We examined associations of perceived and objective NE with ST in the predominantly African American faith-based population of the Washington, D.C. CV Health and Needs Assessment. After using community-based research principles, participants reported NE perceptions, including sidewalks, recreational areas, and crime presence. Factor analysis was conducted to explore pertinent constructs; factor sums were created and combined as Total Perception Score (TPS) (higher score = more favorable perception)...
March 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29339410/maintenance-of-genome-integrity%C3%A2-by-mi2-homologs-chd-3-and-let-418-in%C3%A2-caenorhabditis-elegans
#14
Carolyn A Turcotte, Solomon A Sloat, Julia A Rigothi, Erika Rosenkranse, Alexandra L Northrup, Nicolas P Andrews, Paula M Checchi
Meiotic recombination depends upon the tightly coordinated regulation of chromosome dynamics and is essential for the production of haploid gametes. Central to this process is the formation and repair of meiotic double-stranded breaks (DSBs), which must take place within the constraints of a specialized chromatin architecture. Here, we demonstrate a role for the nucleosome remodeling and deacetylase (NuRD) complex in orchestrating meiotic chromosome dynamics in Caenorhabditis elegans. Our data reveal that the conserved Mi2 homologs Chromodomain helicase DNA binding protein (CHD-3) and its paralog LET-418 facilitate meiotic progression by ensuring faithful repair of DSBs through homologous recombination...
January 16, 2018: Genetics
https://www.readbyqxmd.com/read/29338731/effective-nationwide-school-based-participatory-extramural-program-on-adolescent-body-mass-index-health-knowledge-and-behaviors
#15
Moonseong Heo, Camille C Jimenez, Jean Lim, Carmen R Isasi, Arthur E Blank, David W Lounsbury, Lynn Fredericks, Michelle Bouchard, Myles S Faith, Judith Wylie
BACKGROUND: Adolescent obesity is a major public health concern. Open to all high school students regardless of weight status, HealthCorps is a nationwide program offering a comprehensive high school-based participatory educational program to indirectly address obesity. We tested a hypothesis that the HealthCorps program would decrease BMI z-scores among overweight or obese students, and reduce obesity rates, and evaluated its effects on health knowledge and behaviors. METHODS: HealthCorps aimed to improve student knowledge and behaviors regarding nutrition quality, physical activity, sleep, breakfast intake, and mental resilience...
January 16, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29330124/manipulating-the-epigenome-for-the-treatment-of-disorders-with-thrombotic-complications
#16
REVIEW
Faith A A Kwa, Denise E Jackson
The haemostatic system is tightly regulated to maintain homeostasis to avoid unwanted bleeding or thrombotic complications. Recent research has highlighted the importance of epigenetic changes, such as DNA methylation, histone modifications, and miRNA-based mechanisms, that alter gene expression. This can give rise to dysregulated haemostatic or vascular expressed molecules contributing to the development of thrombotic complications. Targeting these epigenetic changes could provide a new avenue for the treatment of pathological blood clots...
January 9, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29329780/oncogenic-rac1-and-nras-drive-resistance-to-endoplasmic-reticulum-stress-through-mek-erk-signalling
#17
Michael D Bright, Paul A Clarke, Paul Workman, Faith E Davies
Cancer cells are able to survive under conditions that cause endoplasmic reticulum stress (ER-stress), and can adapt to this stress by upregulating cell-survival signalling pathways and down-regulating apoptotic pathways. The cellular response to ER-stress is controlled by the unfolded protein response (UPR). Small Rho family GTPases are linked to many cell responses including cell growth and apoptosis. In this study, we investigate the function of small GTPases in cell survival under ER-stress. Using siRNA screening we identify that RAC1 promotes cell survival under ER-stress in cells with an oncogenic N92I RAC1 mutation...
January 9, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29328134/360-degree-color-hologram-generation-for-real-3d-objects
#18
Eun-Young Chang, Jongho Choi, Sangha Lee, Soonchul Kwon, Jisang Yoo, Minsik Park, Jinwoong Kim
Recently, holographic display and computer-generated holograms calculated from real existing objects have been more actively investigated to support holographic video applications. In this paper, we proposed a method of generating 360-degree color holograms of real 3D objects in an efficient manner. 360-degree 3D images are generated using the actual 3D image acquisition system consisting of a depth camera and a turntable and intermediate view generation. Then, 360-degree color holograms are calculated using a viewing-window-based computer-generated hologram...
January 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29326974/the-largest-deep-ocean-silicic-volcanic-eruption-of-the-past-century
#19
Rebecca Carey, S Adam Soule, Michael Manga, James White, Jocelyn McPhie, Richard Wysoczanski, Martin Jutzeler, Kenichiro Tani, Dana Yoerger, Daniel Fornari, Fabio Caratori-Tontini, Bruce Houghton, Samuel Mitchell, Fumihiko Ikegami, Chris Conway, Arran Murch, Kristen Fauria, Meghan Jones, Ryan Cahalan, Warren McKenzie
The 2012 submarine eruption of Havre volcano in the Kermadec arc, New Zealand, is the largest deep-ocean eruption in history and one of very few recorded submarine eruptions involving rhyolite magma. It was recognized from a gigantic 400-km2 pumice raft seen in satellite imagery, but the complexity of this event was concealed beneath the sea surface. Mapping, observations, and sampling by submersibles have provided an exceptionally high fidelity record of the seafloor products, which included lava sourced from 14 vents at water depths of 900 to 1220 m, and fragmental deposits including giant pumice clasts up to 9 m in diameter...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29326051/-investigation-methods-to-explore-g-protein-coupled-receptor-regulated-translatome
#20
Aurélie Tréfier, Florian Guillou, Pascale Crépieux
With the advent of next-generation sequencing technologies, identifying the translatome, which includes genome-wide ribosome-associated mRNAs, provides new opportunities to define faithfully the protein repertoire of a cell, as opposed to transcriptomic approaches. In addition, the role that extracellular signals such as hormonal modulations could play on the translatome remains to be deciphered. In particular, the regulation of the translatome by G protein-coupled receptors (GPCR) is still poorly described, albeit the trophic role that many receptors of this family play in their target cells...
January 8, 2018: Comptes Rendus Biologies
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