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https://www.readbyqxmd.com/read/29161649/magic-angle-spinning-nmr-below-6%C3%A2-k-with-a-computational-fluid-dynamics-analysis-of-fluid-flow-and-temperature-gradients
#1
Erika L Sesti, Nicholas Alaniva, Peter W Rand, Eric J Choi, Brice J Albert, Edward P Saliba, Faith J Scott, Alexander B Barnes
We report magic angle spinning (MAS) up to 8.5 kHz with a sample temperature below 6 K using liquid helium as a variable temperature fluid. Cross polarization (13)C NMR spectra exhibit exquisite sensitivity with a single transient. Remarkably, (1)H saturation recovery experiments show a (1)H T1 of 21 s with MAS below 6 K in the presence of trityl radicals in a glassy matrix. Leveraging the thermal spin polarization available at 4.2 K versus 298 K should result in 71 times higher signal intensity...
November 11, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29161471/peer-to-peer-mentoring-for-african-american-women-with-lupus-a-feasibility-pilot
#2
Edith M Williams, J Madison Hyer, Ramakrishnan Viswanathan, Trevor D Faith, Delia Voronca, Mulugeta Gebregzaibher, Jim C Oates, Leonard Egede
OBJECTIVE: To examine the feasibility and potential benefits of peer mentoring to improve the disease self-management and quality of life of individuals with systemic lupus erythematosus (SLE). METHODS: Peer mentors were trained and paired with up to three mentees to receive self-management education and support by telephone over 12 weeks. This study took place at an academic teaching hospital in Charleston, South Carolina. Seven quads consisting of one peer mentor and three mentees were matched based on factors such as age, area of residence, marital and work status...
November 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29160826/the-communication-awareness-relationships-and-empowerment-c-a-r-e-model-an-effective-tool-for-engaging-urban-communities-in-community-based-participatory-research
#3
Joniqua Ceasar, Marlene H Peters-Lawrence, Valerie Mitchell, Tiffany M Powell-Wiley
Little is known about recruitment methods for racial/ethnic minority populations from resource-limited areas for community-based health and needs assessments, particularly assessments that incorporate mobile health (mHealth) technology for characterizing physical activity and dietary intake. We examined whether the Communication, Awareness, Relationships and Empowerment (C.A.R.E.) model could reduce challenges recruiting and retaining participants from faith-based organizations in predominantly African American Washington, D...
November 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29156312/identifying-health-conditions-priorities-and-relevant-multilevel-health-promotion-intervention-strategies-in-african-american-churches-a-faith-community-health-needs-assessment
#4
Jannette Berkley-Patton, Carole Bowe Thompson, Andrea Bradley-Ewing, Marcie Berman, Alexandria Bauer, Delwyn Catley, Kathy Goggin, Eric Williams, Cassandra Wainright, Therese Petty, Natasha Aduloju-Ajijola
No abstract text is available yet for this article.
October 31, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29155288/investigation-of-the-practices-legislation-supply-chain-and-regulation-of-opioids-for-clinical-pain-management-in-southern-africa-a-multi-sectoral-cross-national-mixed-methods-study
#5
Eve Namisango, Matthew J Allsop, Richard A Powell, Stefan J Friedrichsdorf, Emmanuel Bk Luyirika, Fatia Kiyange, Edward Mukooza, Chris Ntege, Eunice Garanganga, Mavis Ntombifuthi Ginindza-Mdluli, Faith Mwangi-Powell, Lidia Justino Mondlane, Richard Harding
CONTEXT: Sub-Saharan Africa faces an increasing incidence and prevalence of life-limiting and life-threatening conditions. These conditions are associated with a significant burden of pain linked to high morbidity and disability that is poorly assessed and undertreated. Barriers to effective pain management partly relate to lack of access to opioid analgesia and challenges in their administration. OBJECTIVES: To identify country-specific and broader regional barriers to access, as well as the administration of opioids, and generate recommendations for advancing pain management in Southern Africa...
November 15, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29154753/cyclin-a-cdk1-modulates-plk1-activity-in-prometaphase-to-regulate-kinetochore-microtubule-attachment-stability
#6
Ana Maria G Dumitru, Scott F Rusin, Amber E M Clark, Arminja N Kettenbach, Duane A Compton
The fidelity of chromosome segregation in mitosis is safeguarded by the precise regulation of kinetochore microtubule (k-MT) attachment stability. Previously, we demonstrated that Cyclin A/Cdk1 destabilizes k-MT attachments to promote faithful chromosome segregation. Here, we use quantitative phosphoproteomics to identify 156 Cyclin A/Cdk1 substrates in prometaphase. One Cyclin A/Cdk1 substrate is myosin phosphatase targeting subunit 1 (MYPT1), and we show that MYPT1 localization to kinetochores depends on Cyclin A/Cdk1 activity and that MYPT1 destabilizes k-MT attachments by negatively regulating Plk1 at kinetochores...
November 20, 2017: ELife
https://www.readbyqxmd.com/read/29148354/case-managers-for-high-risk-high-cost-patients-as-agents-and-street-level-bureaucrats
#7
Jeffrey Swanson, William G Weissert
Case management programs often designate a nurse or social worker to take responsibility for guiding care when patients are expected to be expensive or risk a major decline. We hypothesized that though an intuitively appealing idea, careful program design and faithful implementation are essential if case management programs are to succeed. We employed two theory perspectives, principal-agent framework and street-level bureaucratic theory to describe the relationship between program designers (principals) and case managers (agents/street-level bureaucrats) to review 65 case management studies...
August 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29145544/blast-sms-text-messaging-to-facilitate-enrollment-for-cleft-lip-and-palate-surgery-in-zimbabwe
#8
David A Shaye, Faith C Muchemwa, Aleck Gonga, Travis T Tollefson
No abstract text is available yet for this article.
November 16, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29145454/reduction-of-hiv-associated-excess-mortality-by-antiretroviral-treatment-among-tuberculosis-patients-in-kenya
#9
Dickens O Onyango, Courtney M Yuen, Kevin P Cain, Faith Ngari, Enos O Masini, Martien W Borgdorff
BACKGROUND: Mortality from TB continues to be a global public health challenge. TB ranks alongside Human Immunodeficiency Virus (HIV) as the leading infectious causes of death globally. HIV is a major driver of TB related morbidity and mortality while TB is the leading cause of mortality among people living with HIV/AIDS. We sought to determine excess mortality associated with HIV and the effect of antiretroviral therapy on reducing mortality among tuberculosis patients in Kenya. METHODS: We conducted a retrospective analysis of Kenya national tuberculosis program data of patients enrolled from 2013 through 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29143135/the-mediating-role-of-spirituality-meaning-peace-faith-between-psychological-distress-and-mental-adjustment-in-cancer-patients
#10
Paula Jimenez-Fonseca, Urbano Lorenzo-Seva, Pere Joan Ferrando, Alberto Carmona-Bayonas, Carmen Beato, Teresa García, María Del Mar Muñoz, Avinash Ramchandani, Ismael Ghanem, Alejandra Rodríguez-Capote, Carlos Jara, Caterina Calderon
OBJECTIVE: The objectives of this study were (a) to determine the psychometric properties of the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being (FACIT-Sp) scale and (b) to provide that FACIT scores behave one-dimensional to establish the mediating role of spiritual well-being in psychological distress and mental adjustment in a sample of patients with non-metastatic, resected cancer. METHOD: A total of 504 consecutive patients completed the FACIT-Sp, Brief Symptom Inventory, and Mini-Mental Adjustment to Cancer scales...
November 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29142123/initiation-elongation-and-realignment-during-influenza-virus-mrna-synthesis
#11
Aartjan J W Te Velthuis, Judith Oymans
The RNA-dependent RNA polymerase (RdRp) of the influenza A virus replicates and transcribes the viral genome segments in the nucleus of the host cell. To transcribe these viral genome segments, the RdRp 'snatches' capped RNA oligonucleotides from nascent host cell mRNAs and aligns these primers to the ultimate or penultimate nucleotide of the segments for the initiation of viral mRNA synthesis. It has been proposed that this initiation process is not processive and that the RdRp uses a prime-realign mechanism during transcription...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29141960/rapid-molecular-assays-to-study-human-centromere-genomics
#12
Rafael Contreras-Galindo, Sabrina Fischer, Anjan K Saha, John D Lundy, Patrick W Cervantes, Mohamad Mourad, Claire Wang, Brian Qian, Manhong Dai, Fan Meng, Arul Chinnaiyan, Gilbert S Omenn, Mark H Kaplan, David M Markovitz
The centromere is the structural unit responsible for the faithful segregation of chromosomes. Although regulation of centromeric function by epigenetic factors has been well-studied, the contributions of the underlying DNA sequences have been much less well defined, and existing methodologies for studying centromere genomics in biology are laborious. We have identified specific markers in the centromere of 23 of the 24 human chromosomes that allow for rapid PCR assays capable of capturing the genomic landscape of human centromeres at a given time...
November 15, 2017: Genome Research
https://www.readbyqxmd.com/read/29141507/sandwiched-white-adipose-tissue-a-novel-microphysiological-system-of-human-adipose-tissue
#13
Frank H Lau, Kelly Vogel, John P Luckett, Maxwell Hunt, Alicia Meyer, Camille L Rogers, Oren Tessler, Charles L Dupin, Hugo St Hilaire, Kazi N Islam, Trivia Frazier, Jeffrey Gimble, Steven Scahill
White adipose tissue (WAT) is a critical organ in both health and disease. However, physiologically faithful tissue culture models of primary human WAT remain limited, at best. Here we describe a novel WAT culture system in which primary human WAT is sandwiched between tissue-engineered sheets of adipose-derived stromal cells. This construct, called "sandwiched white adipose tissue" (SWAT), can be defined as a Microphysiological System (MPS) since it is a tissue-engineered, multicellular, 3D organ construct produced using human cells...
November 16, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29141229/widespread-translational-remodeling-during-human-neuronal-differentiation
#14
John D Blair, Dirk Hockemeyer, Jennifer A Doudna, Helen S Bateup, Stephen N Floor
Faithful cellular differentiation requires temporally precise activation of gene expression programs, which are coordinated at the transcriptional and translational levels. Neurons express the most complex set of mRNAs of any human tissue, but translational changes during neuronal differentiation remain incompletely understood. Here, we induced forebrain neuronal differentiation of human embryonic stem cells (hESCs) and measured genome-wide RNA and translation levels with transcript-isoform resolution. We found that thousands of genes change translation status during differentiation without a corresponding change in RNA level...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29136683/why-is-meaning-centered-group-psychotherapy-mcgp-effective-enhanced-sense-of-meaning-as-the-mechanism-of-change-for-advanced-cancer-patients
#15
Barry Rosenfeld, Heining Cham, Hayley Pessin, William Breitbart
OBJECTIVES: Meaning-Centered Group Psychotherapy (MCGP) has been demonstrated to be an effective method for improving advanced cancer patients' quality of life and reducing their depression, hopelessness, and desire for hastened death. To further understand MCGP, this study examined the mechanisms of change in MCGP on these outcomes via advanced cancer patients' changes of sense of meaning and peace in life. METHODS: The sample data were from two randomized control trials that compared MCGP (n = 124) to supportive group psychotherapy (n = 94)...
November 14, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29136501/pontine-infantile-glioma-simplified
#16
Vijay Ramaswamy, Michael D Taylor
In this issue of Cancer Cell, Pathania et al. report sporadic childhood histone K27M mutant malignant glioma mouse models that faithfully recapitulate the human tumor phenotypes. Beyond emphasizing the importance of correct timing in mouse modeling of cancer, these models will facilitate research to effectively treat this lethal childhood cancer.
November 13, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29136150/using-value-stream-mapping-to-improve-quality-of-care-in-low-resource-facility-settings
#17
Rohit Ramaswamy, Claire Rothschild, Funmi Alabi, Eric Wachira, Faith Muigai, Nick Pearson
Quality problem or issue: Jacaranda Health (JH) is a Kenya-based organization that attempts to provide affordable, high-quality maternal and newborn healthcare through a chain of private health facilities in Nairobi. Initial assessment: JH needed to adopted quality improvement as an organization-wide strategy to optimize effectiveness and efficiency. Choice of solution: Value Stream Mapping, a Lean Management tool, was used to engage staff in prioritizing opportunities to improve clinical outcomes and patient-centered quality of care...
November 9, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29134204/latent-membrane-protein-1-is-a-novel-determinant-of-epstein-barr-virus-genome-persistence-and-reactivation
#18
Elizabeth A Caves, Rachel M Butch, Sarah A Cook, Laura R Wasil, Chen Chen, Yuanpu Peter Di, Nara Lee, Kathy H Y Shair
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that persistently infects humans, with nearly 95% seropositivity in adults. Infection in differentiating epithelia is permissive, but EBV-associated nasopharyngeal carcinoma (NPC) tumors harbor a clonal and nonproductive latent infection. However, in explanted NPC cultures and epithelial cell lines, episomal EBV genomes are frequently lost. The resulting unstable infection has hampered efforts to study the determinants of EBV persistence and latency in epithelial oncogenesis...
November 2017: MSphere
https://www.readbyqxmd.com/read/29132284/love-matters-exploring-conceptions-of-love-in-rwanda-and-swaziland-and-relationship-to-hiv-and-intimate-partner-violence
#19
Allison Ruark, Erin Stern, Thandeka Dlamini-Simelane, Marie Fidele Kakuze
Health risks such as intimate partner violence (IPV) and HIV infection often occur within intimate sexual relationships, yet the study of love and intimacy is largely absent from health research on African populations. This study explores how women and men in Rwanda and Swaziland understand and represent love in their intimate sexual partnerships. In Rwanda, 58 in-depth interviews with 15 couples, 12 interviews with activists, and 24 focus group discussions were carried out during formative and evaluative research of the Indashyikirwa programme, which aims to reduce IPV and support healthy couple relationships...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29131829/a-non-linear-data-mining-parameter-selection-algorithm-for-continuous-variables
#20
Peyman Tavallali, Marianne Razavi, Sean Brady
In this article, we propose a new data mining algorithm, by which one can both capture the non-linearity in data and also find the best subset model. To produce an enhanced subset of the original variables, a preferred selection method should have the potential of adding a supplementary level of regression analysis that would capture complex relationships in the data via mathematical transformation of the predictors and exploration of synergistic effects of combined variables. The method that we present here has the potential to produce an optimal subset of variables, rendering the overall process of model selection more efficient...
2017: PloS One
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