keyword
MENU ▼
Read by QxMD icon Read
search

"mushroom body"

keyword
https://www.readbyqxmd.com/read/28931572/drosophila-neprilysin-1-rescues-memory-deficits-caused-by-amyloid-%C3%AE-peptide
#1
Oriane Turrel, Valérie Goguel, Thomas Preat
Neprilysins are type-II metalloproteinases known to degrade and inactivate a number of small peptides, in particular the mammalian amyloid-β peptide (Aβ). In Drosophila, several neprilysins expressed in the brain are required for middle-term (MTM) and long-term memory (LTM) in the dorsal paired medial (DPM) neurons, a pair of large neurons that broadly innervate the mushroom bodies (MB), the center of olfactory memory. These data indicate that one or several peptides need to be degraded for MTM and LTM. We have previously shown that the fly amyloid precursor protein (APPL) is required for memory in the MB...
September 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28921711/foxp-expression-identifies-a-kenyon-cell-subtype-in-the-honeybee-mushroom-bodies-linking-them-to-fruitfly-%C3%AE-%C3%AE-c-neurons
#2
Adriana Schatton, Constance Scharff
The arthropod mushroom bodies (MB) are a higher order sensory integration center. In insects, they play a central role in associative olfactory learning and memory. In Drosophila melanogaster (Dm), the highly ordered connectivity of heterogeneous MB neuron populations has been mapped using sophisticated molecular genetic and anatomical techniques. The MB-core subpopulation was recently shown to express the transcription factor FoxP with relevance for decision-making. Here we report the development and adult distribution of a FoxP-expressing neuron population in the MB of honeybees (Apis mellifera, Am) using in situ hybridization and a custom-made antiserum...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28917001/a-neural-network-model-for-familiarity-and-context-learning-during-honeybee-foraging-flights
#3
Jurek Müller, Martin Nawrot, Randolf Menzel, Tim Landgraf
How complex is the memory structure that honeybees use to navigate? Recently, an insect-inspired parsimonious spiking neural network model was proposed that enabled simulated ground-moving agents to follow learned routes. We adapted this model to flying insects and evaluate the route following performance in three different worlds with gradually decreasing object density. In addition, we propose an extension to the model to enable the model to associate sensory input with a behavioral context, such as foraging or homing...
September 15, 2017: Biological Cybernetics
https://www.readbyqxmd.com/read/28916631/experience-during-early-adulthood-shapes-the-learning-capacities-and-the-number-of-synaptic-boutons-in-the-mushroom-bodies-of-honey-bees-apis-mellifera
#4
Amélie Cabirol, Rufus Brooks, Claudia Groh, Andrew B Barron, Jean-Marc Devaud
The honey bee mushroom bodies (MBs) are brain centers required for specific learning tasks. Here, we show that environmental conditions experienced as young adults affect the maturation of MB neuropil and performance in a MB-dependent learning task. Specifically, olfactory reversal learning was selectively impaired following early exposure to an impoverished environment lacking some of the sensory and social interactions present in the hive. In parallel, the overall number of synaptic boutons increased within the MB olfactory neuropil, whose volume remained unaffected...
October 2017: Learning & Memory
https://www.readbyqxmd.com/read/28902472/the-mushroom-body-d1-dopamine-receptor-controls-innate-courtship-drive
#5
Junghwa Lim, Ana I Fernandez, Samantha J Hinojos, Gissel P Aranda, Jacqueline James, Chang-Soo Seong, Kyung-An Han
Mating is critical for species survival and is profoundly regulated by neuromodulators and neurohormones to accommodate internal states and external factors. To identify the underlying neuromodulatory mechanisms, we investigated the roles of dopamine receptors in various aspects of courtship behavior in Drosophila. Here we report that the D1 dopamine receptor dDA1 regulates courtship drive in naïve males. The wild-type naïve males actively courted females regardless their appearance or mating status. On the contrary, the dDA1 mutant (dumb) males exhibited substantially reduced courtship toward less appealing females including decapitated, leg-less and mated females...
September 13, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28900185/anti-a%C3%AE-single-chain-variable-fragment-antibodies-restore-memory-acquisition-in-a-drosophila-model-of-alzheimer-s-disease
#6
Alfonso Martin-Peña, Diego E Rincon-Limas, Pedro Fernandez-Funez
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder triggered by the accumulation of soluble assemblies of the amyloid-β42 (Aβ42) peptide. Despite remarkable advances in understanding the pathogenesis of AD, the development of palliative therapies is still lacking. Engineered anti-Aβ42 antibodies are a promising strategy to stall the progression of the disease. Single-chain variable fragment (scFv) antibodies increase brain penetration and offer flexible options for delivery while maintaining the epitope targeting of full antibodies...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28889104/machine-learning-analysis-identifies-drosophilagrunge-atrophin-as-an-important-learning-and-memory-gene-required-for-memory-retention-and-social-learning
#7
Balint Z Kacsoh, Casey S Greene, Giovanni Bosco
High throughput experiments are becoming increasingly common, and scientists must balance hypothesis driven experiments with genome wide data acquisition. We sought to predict novel genes involved in Drosophila learning and long-term memory from existing public high-throughput data. We performed an analysis using PILGRM, which analyzes public gene expression compendia using machine learning. We evaluated the top prediction alongside genes involved in learning and memory in IMP, an interface for functional relationship networks...
September 9, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28883629/reply-to-pitfalls-of-using-confocal-microscopy-based-automated-quantification-of-synaptic-complexes-in-honeybee-mushroom-bodies-response-to-peng-and-yang-2016
#8
Yi-Chan Peng, En-Cheng Yang
In a comment on our Article "Sublethal Dosage of Imidacloprid Reduces the Microglomerular Density of Honey Bee Mushroom Bodies", Rössler et al. assert that our reported counts are overall lower than previously reported due to the use of automated quantification. We address these issues in this reply.
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28852015/pitfalls-of-using-confocal-microscopy-based-automated-quantification-of-synaptic-complexes-in-honeybee-mushroom-bodies-response-to-peng-and-yang-2016
#9
Wolfgang Rössler, Johannes Spaethe, Claudia Groh
A recent study by Peng and Yang in Scientific Reports using confocal-microscopy based automated quantification of anti-synapsin labeled microglomeruli in the mushroom bodies of honeybee brains reports potentially incorrect numbers of microglomerular densities. Whereas several previous studies using visually supervised or automated counts from confocal images and analyses of serial 3D electron-microscopy data reported consistent numbers of synaptic complexes per volume, Peng and Yang revealed extremely low numbers differing by a factor of 18 or more from those obtained in visually supervised counts, and by a factor 22-180 from numbers in two other studies using automated counts...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851709/imp-and-syp-rna-binding-proteins-govern-decommissioning-of-drosophila-neural-stem-cells
#10
Ching-Po Yang, Tamsin J Samuels, Yaling Huang, Lu Yang, David Ish-Horowicz, Ilan Davis, Tzumin Lee
The termination of the proliferation of Drosophila neural stem cells, also known as neuroblasts (NBs), requires a "decommissioning" phase that is controlled in a lineage-specific manner. Most NBs, with the exception of those of the Mushroom body (MB), are decommissioned by the ecdysone receptor and mediator complex causing them to shrink during metamorphosis, followed by nuclear accumulation of Prospero and cell cycle exit. Here, we demonstrate that the levels of Imp and Syp RNA-binding proteins regulate NB decommissioning...
August 29, 2017: Development
https://www.readbyqxmd.com/read/28826476/eyeless-uncouples-mushroom-body-neuroblast-proliferation-from-dietary-amino-acids-in-drosophila
#11
Conor W Sipe, Sarah E Siegrist
Cell proliferation is coupled with nutrient availability. If nutrients become limited, proliferation ceases, because growth factor and/or PI3-kinase activity levels become attenuated. Here, we report an exception to this generality within a subpopulation of Drosophila neural stem cells (neuroblasts). We find that most neuroblasts enter and exit cell cycle in a nutrient-dependent manner that is reversible and regulated by PI3-kinase. However, a small subset, the mushroom body neuroblasts, which generate neurons important for memory and learning, divide independent of dietary nutrient conditions and PI3-kinase activity...
August 9, 2017: ELife
https://www.readbyqxmd.com/read/28811313/a-key-role-for-foxq2-in-anterior-head-and-central-brain-patterning-in-insects
#12
Peter Kitzmann, Matthias Weißkopf, Magdalena Ines Schacht, Gregor Bucher
Anterior patterning of animals is based on a set of highly conserved transcription factors but the interactions within the protostome anterior gene regulatory network (aGRN) remain enigmatic. Here, we identify the red flour beetle Tribolium castaneum ortholog of foxQ2 (Tc-foxQ2) as a novel upstream component of the aGRN. It is required for the development of the labrum and higher order brain structures, namely the central complex and the mushroom bodies. We reveal Tc-foxQ2 interactions by RNAi and heat shock-mediated misexpression...
August 15, 2017: Development
https://www.readbyqxmd.com/read/28805639/development-and-evolution-of-brain-allometry-in-wasps-vespidae-size-ecology-and-sociality
#13
REVIEW
Sean O'Donnell, Susan Bulova
We review research on brain development and brain evolution in the wasp family Vespidae. Basic vespid neuroanatomy and some aspects of functional neural circuitry are well-characterized, and genomic tools for exploring brain plasticity are being developed. Although relatively modest in terms of species richness, the Vespidae include species spanning much of the known range of animal social complexity, from solitary nesters to highly eusocial species with some of the largest known colonies and multiple reproductives...
August 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28796202/the-complete-connectome-of-a-learning-and-memory-centre-in-an-insect-brain
#14
Katharina Eichler, Feng Li, Ashok Litwin-Kumar, Youngser Park, Ingrid Andrade, Casey M Schneider-Mizell, Timo Saumweber, Annina Huser, Claire Eschbach, Bertram Gerber, Richard D Fetter, James W Truman, Carey E Priebe, L F Abbott, Andreas S Thum, Marta Zlatic, Albert Cardona
Associating stimuli with positive or negative reinforcement is essential for survival, but a complete wiring diagram of a higher-order circuit supporting associative memory has not been previously available. Here we reconstruct one such circuit at synaptic resolution, the Drosophila larval mushroom body. We find that most Kenyon cells integrate random combinations of inputs but that a subset receives stereotyped inputs from single projection neurons. This organization maximizes performance of a model output neuron on a stimulus discrimination task...
August 9, 2017: Nature
https://www.readbyqxmd.com/read/28769066/long-term-memory-requires-sequential-protein-synthesis-in-three-subsets-of-mushroom-body-output-neurons-in-drosophila
#15
Jie-Kai Wu, Chu-Yi Tai, Kuan-Lin Feng, Shiu-Ling Chen, Chun-Chao Chen, Ann-Shyn Chiang
Creating long-term memory (LTM) requires new protein synthesis to stabilize learning-induced synaptic changes in the brain. In the fruit fly, Drosophila melanogaster, aversive olfactory learning forms several phases of labile memory to associate an odor with coincident punishment in the mushroom body (MB). It remains unclear how the brain consolidates early labile memory into LTM. Here, we survey 183 Gal4 lines containing almost all 21 distinct types of MB output neurons (MBONs) and show that sequential synthesis of learning-induced proteins occurs at three types of MBONs...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28760967/deep-evolutionary-conservation-of-autism-related-genes
#16
Hagai Y Shpigler, Michael C Saul, Frida Corona, Lindsey Block, Amy Cash Ahmed, Sihai D Zhao, Gene E Robinson
E. O. Wilson proposed in Sociobiology that similarities between human and animal societies reflect common mechanistic and evolutionary roots. When introduced in 1975, this controversial hypothesis was beyond science's ability to test. We used genomic analyses to determine whether superficial behavioral similarities in humans and the highly social honey bee reflect common molecular mechanisms. Here, we report that gene expression signatures for individual bees unresponsive to various salient social stimuli are significantly enriched for autism spectrum disorder-related genes...
July 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28756946/fragile-x-mental-retardation-protein-requirements-in-activity-dependent-critical-period-neural-circuit-refinement
#17
Caleb A Doll, Dominic J Vita, Kendal Broadie
Activity-dependent synaptic remodeling occurs during early-use critical periods, when naive juveniles experience sensory input. Fragile X mental retardation protein (FMRP) sculpts synaptic refinement in an activity sensor mechanism based on sensory cues, with FMRP loss causing the most common heritable autism spectrum disorder (ASD), fragile X syndrome (FXS). In the well-mapped Drosophila olfactory circuitry, projection neurons (PNs) relay peripheral sensory information to the central brain mushroom body (MB) learning/memory center...
August 7, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28743801/foxq2-has-a-key-role-in-anterior-head-and-central-brain-patterning-in-insects
#18
Peter Kitzmann, Matthias Weißkopf, Magdalena Ines Schacht, Gregor Bucher
Anterior patterning of animals is based on a set of highly conserved transcription factors but the interactions within the protostome anterior gene regulatory network (aGRN) remain enigmatic. Here, we identify the foxQ2 ortholog of the red flour beetle Tribolium castaneum as novel upstream component of the aGRN. It is required for the development of the labrum and higher order brain structures, namely the central complex and the mushroom bodies. We reveal Tc-foxQ2 interactions by RNAi and heat shock-mediated misexpression...
July 25, 2017: Development
https://www.readbyqxmd.com/read/28740466/a-tyrosine-hydroxylase-characterization-of-dopaminergic-neurons-in-the-honey-bee-brain
#19
Stevanus R Tedjakumala, Jacques Rouquette, Marie-Laure Boizeau, Karen A Mesce, Lucie Hotier, Isabelle Massou, Martin Giurfa
Dopamine (DA) plays a fundamental role in insect behavior as it acts both as a general modulator of behavior and as a value system in associative learning where it mediates the reinforcing properties of unconditioned stimuli (US). Here we aimed at characterizing the dopaminergic neurons in the central nervous system of the honey bee, an insect that serves as an established model for the study of learning and memory. We used tyrosine hydroxylase (TH) immunoreactivity (ir) to ensure that the neurons detected synthesize DA endogenously...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28728024/origins-of-cell-type-specific-olfactory-processing-in-the-drosophila-mushroom-body-circuit
#20
Kengo Inada, Yoshiko Tsuchimoto, Hokto Kazama
How cell-type-specific physiological properties shape neuronal functions in a circuit remains poorly understood. We addressed this issue in the Drosophila mushroom body (MB), a higher olfactory circuit, where neurons belonging to distinct glomeruli in the antennal lobe feed excitation to three types of intrinsic neurons, α/β, α'/β', and γ Kenyon cells (KCs). Two-photon optogenetics and intracellular recording revealed that whereas glomerular inputs add similarly in all KCs, spikes were generated most readily in α'/β' KCs...
July 19, 2017: Neuron
keyword
keyword
81079
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"