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fibrous cap thickness

Xiao-Qing Cao, Xin-Xin Liu, Meng-Meng Li, Yu Zhang, Liang Chen, Lin Wang, Ming-Xue Di, Mei Zhang
The rupture and erosion of atherosclerotic plaque can induce coronary thrombosis. Prolyl-4-hydroxylase (P4H) plays a central role in the synthesis of all known types of collagens, which are the most abundant constituent of the extracellular matrix in atherosclerotic plaque. The pathogenesis of atherosclerosis is thought to be in part caused by shear stress. In this study, we aimed to investigate a relationship between P4Hα1 and shear stress-induced atherosclerotic plaque. Carotid arteries of ApoE-/- mice were exposed to low and oscillatory shear stress conditions by the placement of a shear stress cast for 2 weeks; we divided 60 male ApoE-/- mice into three groups for treatments with saline (mock) (n = 20), empty lentivirus (lenti-EGFP) (n = 20), and lentivirus-P4Hα1 (lenti-P4Hα1) (n = 20)...
2016: Disease Markers
Maria D Radu, Kyohei Yamaji, Hector M García-García, Serge Zaugg, Masanori Taniwaki, Konstantinos C Koskinas, Patrick W Serruys, Stephan Windecker, Jouke Dijkstra, Lorenz Räber
AIMS: The minimum fibrous cap thickness (FCT) is considered a major criterion of coronary plaque vulnerability according to autopsy studies. We aimed to assess the reproducibility in the measurement of the optical coherence tomography (OCT)-detected minimum FCT and the agreement in the classification of thin-cap fibroatheroma (TCFA), by a software-based semi-automatic method compared with the manual method. METHODS AND RESULTS: A total of 50 frames with fibroatheromas (FA) were randomly selected from the Integrated Biomarker Imaging Study-4 (IBIS-4)...
October 10, 2016: EuroIntervention
Hendrik H G Hansen, Gert Jan de Borst, Michiel L Bots, Frans L Moll, Gerard Pasterkamp, Chris L de Korte
BACKGROUND AND PURPOSE: Carotid plaque rupture is a major cause of stroke. Key issue for risk stratification is early identification of rupture-prone plaques. A noninvasive technique, compound ultrasound strain imaging, was developed providing high-resolution radial deformation/strain images of atherosclerotic plaques. This study aims at in vivo validation of compound ultrasound strain imaging in patients by relating the measured strains to typical features of vulnerable plaques derived from histology after carotid endarterectomy...
November 2016: Stroke; a Journal of Cerebral Circulation
Tomasz Roleder, Keyvan Karimi Galougahi, Chee Yang Chin, Navdeep K Bhatti, Emmanouil Brilakis, Tamim M Nazif, Ajay J Kirtane, Dimitri Karmpaliotis, Wojciech Wojakowski, Martin B Leon, Gary S Mintz, Akiko Maehara, Gregg W Stone, Ziad A Ali
AIMS: Near-infrared spectroscopy (NIRS) has been employed to assess the composition of the atherosclerotic plaques in native coronary arteries. However, little is known about the detection of neoatherosclerosis by NIRS in in-stent restenosis (ISR). The aim of the study was to assess the relationship between the distribution of lipid determined by NIRS and morphology of ISR on optical coherence tomography (OCT). METHODS AND RESULTS: We performed both NIRS and OCT in 39 drug-eluting stents with ISR...
September 27, 2016: European Heart Journal Cardiovascular Imaging
Ruoxi Zhang, Shuyuan Chen, Hui Zhang, Qi Liu, Jianpang Xing, Qi Zhao, Yu Wang, Bo Yu, Jingbo Hou
This study used optical coherence tomography (OCT) to investigate the effects of systemic methotrexate, in combination with a drug-eluting stent, on in-stent neoatherosclerosis in a rabbit model. Sirolimus-eluting stents were surgically implanted in the right common carotid arteries of 200 male New Zealand White rabbits; the animals received a high-fat diet, beginning one week before stent implantation. Each animal was randomly assigned to 1 of 4 groups, receiving intravenous injections of either methotrexate (0...
2016: Scientific Reports
Michael R Preusch, Jonas Rusnak, Kathrin Staudacher, Carolin Mogler, Lorenz Uhlmann, Philipp Sievers, Florian Bea, Hugo A Katus, Erwin Blessing, Ingo Staudacher
OBJECTIVE: There is increasing evidence supporting the role of platelets in atherosclerotic vascular disease. The G-protein-coupled receptor P2Y12 is a central mediator of platelet activation and aggregation but has also been linked to platelet-independent vascular disease. Ticagrelor is an oral P2Y12 antagonist that is used as a standard treatment in patients after acute myocardial infarction. However, the effects of ticagrelor on advanced atherosclerosis have not been investigated. MATERIALS AND METHODS: Twenty-week-old apolipoprotein-E-deficient mice received standard chow or standard chow supplemented with 0...
2016: Drug Design, Development and Therapy
Nana Dong, Zulong Xie, Jiannan Dai, Wei Wang, Rong Sun, Yefei Zhan, Meng Sun, Jinwei Tian, Bo Yu
AIMS: The incidence of cardiac events is increased in diabetic patients even after lipid-lowering therapy. This study aimed to compare the statin-induced changes in the characteristics of vulnerable plaques in patients without diabetes mellitus (DM) and in those with better- or poorly controlled DM, measured by optical coherence tomography (OCT). METHODS: This was a retrospective study of 99 non-culprit lipid-rich plaques from 75 patients who underwent intensive OCT imaging examination...
September 2, 2016: Acta Diabetologica
Juqing Song, Huichang Gao, Guanglin Zhu, Xiaodong Cao, Xuetao Shi, Yingjun Wang
The development of modern biomedical nanotechnology requires three-dimensional macrostructures with nanotextures to meet the requirements for practical applications in intricate biological systems. Additionally, the restoration and regeneration of some specific body tissues and organs rely on the function of conductive polymers, which can provide electrical cues for cells. In this study, we fabricated three-dimensional composite nanofibre macrostructures of polycaprolactone (PCL) with different concentrations of polyaniline (PANi) by employing an improved electrospinning technology with a specially designed collector...
2016: Biofabrication
Joana R Viola, Patricia Lemnitzer, Yvonne Jansen, Gergely Csaba, Carla Winter, Carlos Neideck, Carlos Silvestre-Roig, Gunnar Dittmar, Yvonne Döring, Maik Drechsler, Christian Weber, Ralf Zimmer, Nicolas Cenac, Oliver Soehnlein
RATIONALE: Atheroprogression is a consequence of nonresolved inflammation, and currently a comprehensive overview of the mechanisms preventing resolution is missing. However, in acute inflammation, resolution is known to be orchestrated by a switch from inflammatory to resolving lipid mediators. Therefore, we hypothesized that lesional lipid mediator imbalance favors atheroprogression. OBJECTIVE: To understand the lipid mediator balance during atheroprogression and to establish an interventional strategy based on the delivery of resolving lipid mediators...
October 14, 2016: Circulation Research
Yu Kataoka, Rishi Puri, Muhammad Hammadah, Bhanu Duggal, Kiyoko Uno, Samir R Kapadia, E Murat Tuzcu, Steven E Nissen, Peta King, Stephen J Nicholls
BACKGROUND: Numerous reports suggest sex-related differences in atherosclerosis. Frequency-domain optical coherence tomography has enabled visualization of plaque microstructures associated with disease instability. The prevalence of plaque microstructures between sexes has not been characterized. We investigated sex differences in plaque features in patients with coronary artery disease. METHODS AND RESULTS: Nonculprit plaques on frequency-domain optical coherence tomography imaging were compared between men and women with either stable coronary artery disease (n=320) or acute coronary syndromes (n=115)...
August 2016: Circulation. Cardiovascular Imaging
Amy L Gin, Rocco Vergallo, Yoshiyasu Minami, Daniel S Ong, Jingbo Hou, Haibo Jia, Tsunenari Soeda, Sining Hu, Shaosong Zhang, Hang Lee, Bo Yu, Ik-Kyung Jang
OBJECTIVES: The aim of this study was to examine coronary plaque morphology after initiation of statins and compare changes in plaque morphology in patients presenting with acute coronary syndrome (ACS) versus stable angina pectoris (SAP). BACKGROUND: ACS is associated with a pan-inflammatory state, and intraplaque features of inflammation correlate with coronary plaque progression. Statins have known anti-inflammatory properties that may contribute toward their beneficial cardiovascular effects...
July 27, 2016: Coronary Artery Disease
Fabrizio Montecucco, Alexander I Bondarenko, Sébastien Lenglet, Fabienne Burger, Fabiana Piscitelli, Federico Carbone, Aline Roth, Luca Liberale, Franco Dallegri, Karim J Brandt, Rodrigo A Fraga-Silva, Nikolaos Stergiopulos, Vincenzo Di Marzo, François Mach
Endocannabinoids modulate atherogenesis by triggering different receptors. Recently, orphan G protein-coupled receptors (GPRs) were suggested to be activated by endocannabinoids, possibly regulating vasorelaxation. Here, we investigated whether GPR55 antagonism with CID16020046 would impact on atherosclerotic size and inflammation in two mouse models of early and more advanced atherogenesis. Eleven-week old ApoE-/- mice were fed either a normal diet ([ND] for 16 weeks) or a high-cholesterol diet ([HD] for 11 weeks), resulting in different degrees of hypercholesterolaemia and size of atherosclerosis...
July 28, 2016: Thrombosis and Haemostasis
Yiannis S Chatzizisis, Konstantinos Toutouzas, Andreas A Giannopoulos, Maria Riga, Antonios P Antoniadis, Yusuke Fujinom, Dimitrios Mitsouras, Vassilis G Koutkias, Grigorios Cheimariotis, Charalampos Doulaverakis, Ioannis Tsampoulatidis, Ioanna Chouvarda, Ioannis Kompatsiaris, Sunao Nakamura, Frank J Rybicki, Nicos Maglaveras, Dimitris Tousoulis, George D Giannoglou
AIMS: The association of low endothelial shear stress (ESS) with high-risk plaque (HRP) has not been thoroughly investigated in humans. We investigated the local ESS and lumen remodelling patterns in HRPs using optical coherence tomography (OCT), developed the shear stress score, and explored its association with the prevalence of HRPs and clinical outcomes. METHODS AND RESULTS: A total of 35 coronary arteries from 30 patients with stable angina or acute coronary syndrome (ACS) were reconstructed with three dimensional (3D) OCT...
July 26, 2016: European Heart Journal Cardiovascular Imaging
Mandy O J Grootaert, Dorien M Schrijvers, Hanne Van Spaendonk, Annelies Breynaert, Nina Hermans, Viviane O Van Hoof, Nozomi Takahashi, Peter Vandenabeele, Soon Ha Kim, Guido R Y De Meyer, Wim Martinet
BACKGROUND AND AIMS: A large necrotic core is a key feature of atherosclerotic plaque instability. Necrotic cellular debris accumulates in the lipid-rich core and promotes inflammation, destabilization and ultimately rupture of the plaque. Although the role of necrosis in atherosclerosis is rather clear-cut, not many strategies have been performed up till now to specifically target plaque necrosis. In the present study, we tested the plaque stabilizing potential of NecroX-7, a novel compound with antioxidative and anti-necrotic properties...
September 2016: Atherosclerosis
Jennifer E Phipps, Taylor Hoyt, Deborah Vela, Tianyi Wang, Joel E Michalek, L Maximilian Buja, Ik-Kyung Jang, Thomas E Milner, Marc D Feldman
BACKGROUND: Intravascular optical coherence tomography (IVOCT) images are recorded by detecting light backscattered within coronary arteries. We hypothesize that non-thin-capped fibroatheroma (TCFA) causes may scatter light to create the false appearance of IVOCT TCFA. METHODS AND RESULTS: Ten human cadaver hearts were imaged with IVOCT (n=14 coronary arteries). IVOCT and histological TCFA images were coregistered and compared. Of 21 IVOCT TCFAs (fibrous cap <65 μm, lipid arc >1 quadrant), only 8 were true histological TCFA...
July 2016: Circulation. Cardiovascular Interventions
Guillaume Zahnd, Jelle Schrauwen, Antonios Karanasos, Evelyn Regar, Wiro Niessen, Theo van Walsum, Frank Gijsen
PURPOSE: Identification of rupture-prone plaques in coronary arteries is a major clinical challenge. Fibrous cap thickness and wall shear stress are two relevant image-based risk factors, but these two parameters are generally computed and analyzed separately. Accordingly, combining these two parameters can potentially improve the identification of at-risk regions. Therefore, the purpose of this study is to investigate the feasibility of the fusion of wall shear stress and fibrous cap thickness of coronary arteries in patient data...
October 2016: International Journal of Computer Assisted Radiology and Surgery
Doina Butcovan, Veronica Mocanu, Dana Baran, Diana Ciurescu, Grigore Tinica
The types of lesion instability responsible for the majority of acute coronary events frequently include plaque disruption and plaque erosion with superimposed thrombosis. The term 'vulnerable plaque is used to describe atherosclerotic (ATS) plaques that are particularly prone to rupture and susceptible to thrombus formation, such as the thin-cap fibroatheroma (TCFA). The aim of the present study was to assess the morphological and histological differences between plaques that are unstable and those that are vulnerable to instability...
May 2016: Experimental and Therapeutic Medicine
Annette M Kok, Lambert Speelman, Renu Virmani, Antonius F W van der Steen, Frank J H Gijsen, Jolanda J Wentzel
BACKGROUND: Stress calculations in atherosclerotic coronary vulnerable plaques can aid in predicting coronary cap rupture. In vivo plaque geometry and composition of coronary arteries can merely be obtained via intravascular imaging. Only optical driven imaging techniques have sufficient resolution to visualize the fibrous cap, but due to limited penetration depth deeper components such as the backside of the necrotic core (NC) are generally not visible. The goal of this study was to investigate whether peak cap stresses can be approximated by reconstructing the backside of the NC...
2016: Biomedical Engineering Online
Yoshiyasu Minami, Jingbo Hou, Lei Xing, Haibo Jia, Sining Hu, Rocco Vergallo, Tsunenari Soeda, Hang Lee, Shaosong Zhang, Bo Yu, Ik-Kyung Jang
Although the clinical benefit of statins have been demonstrated in both genders, gender differences in the response to statin therapy on plaque morphologic changes have not been reported. A total of 66 nonculprit plaques from 46 patients who had serial image acquisition at baseline, 6 months, and 12 months by both optical coherence tomography and intravascular ultrasound (IVUS) were included. Patients were treated with atorvastatin 60 mg (AT60) or 20 mg (AT20). The baseline characteristics were similar between women (n = 16) and men (n = 30) except for age (59...
June 15, 2016: American Journal of Cardiology
Victoria Ulrich, Noemi Rotllan, Elisa Araldi, Amelia Luciano, Philipp Skroblin, Mélanie Abonnenc, Paola Perrotta, Xiaoke Yin, Ashley Bauer, Kristen L Leslie, Pei Zhang, Binod Aryal, Rusty L Montgomery, Thomas Thum, Kathleen Martin, Yajaira Suarez, Manuel Mayr, Carlos Fernandez-Hernando, William C Sessa
Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve plaque morphology and stabilize lesions. Here, we demonstrate that chronic administration of LNA-miR-29 into an atherosclerotic mouse model improves indices of plaque morphology. This occurs due to upregulation of miR-29 target genes of the ECM (col1A and col3A) resulting in reduced lesion size, enhanced fibrous cap thickness, and reduced necrotic zones...
June 1, 2016: EMBO Molecular Medicine
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