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fibrous cap thickness

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https://www.readbyqxmd.com/read/28738484/-correlation-between-serum-inflammatory-cytokine-levels-and-fibrous-cap-thickness-of-fibrofatty-plaque-in-coronary-culprit-lesions
#1
Y Zhong, F Ye, W You, Z M Wu
Objective: To identify the correlation between serum inflammatory cytokine levels including high sensitive C reactive protein (hs-CRP) and lipoprotein associated phospholipase (Lp-PLA2) and the fibrous cap thickness of fibrofatty plaque in coronary culprit lesions. Methods: Clinical data of 117 patients with selective coronary artery angiography diagnosed coronary artery disease admitted to our hospital from January 2015 to January 2016 were retrospective analyzed. According to type of coronary disease, patients were divided into 3 subgroups: SAP group (containing 47 stable angina patients), UAP group (containing 52 unstable angina patients), and NSTEMI group(containing 18 acute non ST segment elevation myocardial infarction patients)...
July 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28711401/performance-of-acoustic-radiation-force-impulse-ultrasound-imaging-for-carotid-plaque-characterization-with-histologic-validation
#2
Tomasz J Czernuszewicz, Jonathon W Homeister, Melissa C Caughey, Yue Wang, Hongtu Zhu, Benjamin Y Huang, Ellie R Lee, Carlos A Zamora, Mark A Farber, Joseph J Fulton, Peter F Ford, William A Marston, Raghuveer Vallabhaneni, Timothy C Nichols, Caterina M Gallippi
OBJECTIVE: Stroke is commonly caused by thromboembolic events originating from ruptured carotid plaque with vulnerable composition. This study assessed the performance of acoustic radiation force impulse (ARFI) imaging, a noninvasive ultrasound elasticity imaging method, for delineating the composition of human carotid plaque in vivo with histologic validation. METHODS: Carotid ARFI images were captured before surgery in 25 patients undergoing clinically indicated carotid endarterectomy...
July 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28697847/the-impact-of-serum-trans-fatty-acids-concentration-on-plaque-vulnerability-in-patients-with-coronary-artery-disease-assessment-via-optical-coherence-tomography
#3
Yoshinori Nagasawa, Toshiro Shinke, Ryuji Toh, Tatsuro Ishida, Hiromasa Otake, Tomofumi Takaya, Daisuke Sugiyama, Takayosi Toba, Masaru Kuroda, Hachidai Takahashi, Daisuke Terashita, Natsuko Tahara, Yuto Shinkura, Kenzo Uzu, Daiji Kashiwagi, Koji Kuroda, Yuichiro Nagano, Hiroyuki Yamamoto, Kenichi Yanaka, Yoshiro Tsukiyama, Ken-Ichi Hirata
BACKGROUND AND AIMS: Recent epidemiological studies have showed that excessive intake of trans fatty acids (TFA) can be a residual risk for the development of coronary artery disease (CAD) even under medical management, including statins. This study aimed at investigating the association between lipid profile, including serum TFA concentration, and plaque vulnerability using optical coherence tomography (OCT). METHODS: The level of serum elaidic acid, a major TFA component, was measured using gas chromatography in 161 consecutively enrolled patients with CAD under guideline-directed risk factor management...
June 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28684455/identification-and-quantitative-assessment-of-different-components-of-intracranial-atherosclerotic-plaque-by-ex-vivo-3t-high-resolution-multicontrast-mri
#4
Y Jiang, W Peng, B Tian, C Zhu, L Chen, X Wang, Q Liu, Y Wang, Z Xiang, A J Degnan, Z Teng, D Saloner, J Lu
BACKGROUND AND PURPOSE: High-resolution 3T MR imaging can visualize intracranial atherosclerotic plaque. However, histologic validation is still lacking. This study aimed to evaluate the ability of 3T MR imaging to identify and quantitatively assess intracranial atherosclerotic plaque components ex vivo with histologic validation. MATERIALS AND METHODS: Fifty-three intracranial arterial specimens with atherosclerotic plaques from 20 cadavers were imaged by 3T MR imaging with T1, T2, and proton-density-weighted FSE and STIR sequences...
July 6, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28674269/detection-of-ceramide-a-risk-factor-for-coronary-artery-disease-in-human-coronary-plaques-by-fluorescent-angioscopy
#5
Yasumi Uchida, Yasuto Uchida, Takanobu Kobayashi, Seiichiro Shirai, Nobuyuki Hiruta, Ei Shimoyama, Tsuyoshi Tabata
BACKGROUND: The presence of ceramide in human coronary plaques is a risk factor for ischemic heart disease, but its visualization in the human vessel wall is currently beyond the scope of any available imaging techniques.Methods and Results:Deposition of ceramide was examined by fluorescent angioscopy (FA) and microscopy (FM) using golden fluorescence (Go) as a specific marker of ceramide in yellow plaques, which were obtained from 23 autopsy subjects and classified by conventional angioscopy and histology...
June 30, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28673240/association-of-platelet-to-lymphocyte-ratio-with-non-culprit-atherosclerotic-plaque-vulnerability-in-patients-with-acute-coronary-syndrome-an-optical-coherence-tomography-study
#6
Xuedong Wang, Zulong Xie, Xinxin Liu, Xingtao Huang, Jiale Lin, Dan Huang, Bo Yu, Jingbo Hou
BACKGROUND: The platelet to lymphocyte ratio (PLR), an indirect inflammatory biomarker, has been recently demonstrated to be associated with severity of coronary artery disease. In the present study, we sought to investigate whether PLR is associated with vulnerable plaque characteristics of non-culprit lesions in patients with acute coronary syndrome (ACS). METHODS: The patients in our study were divided into two groups (high PLR group and low PLR group). A total of 119 non-culprit plaques from 71 patients with ACS were assessed by optical coherence tomography (OCT)...
July 3, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28635311/type-d-personality-but-not-type-a-behavior-pattern-is-associated-with-coronary-plaque-vulnerability
#7
Ping Lin, Ling Li, Yini Wang, Zhenjuan Zhao, Guojie Liu, Wei Chen, Hui Tao, Xueqin Gao
Personality traits are associated with major adverse coronary events (MACE) in patients with coronary artery disease (CAD). However, the link between personality traits and intravascular morphology in CAD patients is poorly understood. This study investigated the relationship between personality traits, specifically Type A behavior pattern and Type D personality, and plaque vulnerability. After adjustment for demographic and clinical factors, multivariable regression analysis showed no association between Type A and optical coherence tomography indices...
June 21, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28592134/circulating-annexin-a5-levels-are-associated-with-carotid-intima-media-thickness-but-not-coronary-plaque-composition
#8
Mathias Burgmaier, Sebastian Reith, Leon Schurgers, Florian Kahles, Nikolaus Marx, Chris Reutelingsperger
BACKGROUND: Annexin A5 (anxA5) is involved in processes which are crucial in atherogenesis. However, anxA5's relationship with atherosclerotic lesion extension and plaque composition in high-risk patients with type 2 diabetes remains unclear. Thus, we characterized the association between circulating anxA5 levels with atherosclerotic burden and coronary plaque composition in diabetes mellitus patients. METHODS: Intima-media thickness was determined in 96 diabetes mellitus patients with stable coronary artery disease...
June 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28404965/impact-of-statins-therapy-on-morphological-changes-in-lipid-rich-plaques-stratified-by-10-year-framingham-risk-score-a-serial-optical-coherence-tomography-study
#9
Yinchun Zhu, Lin Lin, Chao Wang, Haibo Jia, Sining Hu, Lulu Li, Xiling Zhang, Gonghui Zheng, Yan Wang, Rong Sun, Abigail Afolabi, Irina Mustafina, Jingbo Hou, Shaosong Zhang, Bo Yu
The aim of the study was to investigate the impact of statins therapy on morphological changes of lipid-rich plaques by OCT (optical coherence tomography) in patients with known CHD (coronary heart disease), stratified by FRS. Ninety-seven lipid-rich plaques from sixty-nine patients who received statins therapy and underwent serial OCT images (baseline, 6-month and 12-month) were divided into 2 groups according to the FRS (framingham risk score): low risk group A (FRS<10%, N=35, n=45), moderate to high risk group B (FRS≥10%, N=34, n=52)...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28329036/predictive-value-of-plaque-morphology-assessed-by-frequency-domain-optical-coherence-tomography-for-impaired-microvascular-perfusion-after-elective-stent-implantation-the-intracoronary-electrocardiogram-study
#10
Hiroki Ikenaga, Satoshi Kurisu, Tsukasa Nakao, Shingo Kono, Yoji Sumimoto, Noriaki Watanabe, Takashi Shimonaga, Tadanao Higaki, Toshitaka Iwasaki, Naoya Mitsuba, Ken Ishibashi, Yoshihiro Dohi, Yukihiro Fukuda, Yasuki Kihara
Aims: This study was undertaken to assess the association between plaque features at culprit lesions assessed by frequency-domain optical coherence tomography (FD-OCT) and impaired microvascular perfusion estimated by intracoronary electrocardiogram (IcECG) after elective percutaneous coronary intervention (PCI). Furthermore, we investigated whether IcECG could predict future cardiac events. Methods and results: This study consisted of 84 patients who underwent both FD-OCT and IcECG during PCI...
March 7, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28304220/high-resolution-magnetic-resonance-imaging-of-carotid-atherosclerotic-plaques-a-correlation-study-with-histopathology
#11
Zhangyong Xia, Hua Yang, Xiaochun Yuan, Jiyue Wang, Shigang Zhang, Liyong Zhang, Yang Qu, Jun Chen, Liqun Jiao, Le-Xin Wang, Yifeng Du
BACKGROUND: This study aimed to utilize high-resolution magnetic resonance imaging (MRI) to investigate the characteristics of stable and vulnerable carotid arteriosclerotic plaques, with correlations to histopathological findings. PATIENTS AND METHODS: High-resolution MRI was performed in 817 patients, using three-dimensional magnetic resonance angiography. Plaque composition was evaluated by measuring the areas occupied by calcification, a lipid-rich necrotic core, intra-plaque haemorrhage, and fibrous cap rupture...
March 17, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28214139/accuracy-of-computed-tomography-angiography-to-identify-thin-cap-fibroatheroma-detected-by-optical-coherence-tomography
#12
Nobuo Tomizawa, Kodai Yamamoto, Shinichi Inoh, Takeshi Nojo, Sunao Nakamura
BACKGROUND: Thin-cap fibroatheroma (TCFA) is assumed to cause acute coronary syndromes. OBJECTIVE: To compare the accuracy of different models for diagnosing TCFA using parameters derived by CT, validated against optical coherence tomography (OCT). METHODS: One hundred twenty-nine plaques in 106 patients were analyzed using data acquired by 64-row CT with a reconstruction thickness of 0.67 mm and an increment of 0.33 mm. TCFA was defined by OCT as a plaque with lipid content in ≥2 quadrants and the thinnest part of the fibrous cap measuring ≤65 μm...
February 9, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28059849/is-age-an-important-factor-for-vascular-response-to-statin-therapy-a-serial-optical-coherence-tomography-and-intravascular-ultrasound-study
#13
Jiannan Dai, Jingbo Hou, Lei Xing, Haibo Jia, Sining Hu, Tsunenari Soeda, Yoshiyasu Minami, Daniel Ong, Rocco Vergallo, Shaosong Zhang, Hang Lee, Bo Yu, Ik-Kyung Jang
OBJECTIVE: Age-related structural and functional changes in vessel wall may affect the time course of vascular response to statin therapy. In this study, we sought to compare the response of lipid-rich plaque to statin therapy in elderly versus younger patients using optical coherence tomography and intravascular ultrasound. PATIENTS AND METHODS: Sixty-nine patients who underwent serial optical coherence tomography and intravascular ultrasound at the time point of baseline, 6, and 12 months were divided into two groups according to median age: group A (age<57 years, n=35) and group B (age≥57 years, n=34)...
May 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28057387/principal-strain-vascular-elastography-simulation-and-preliminary-clinical-evaluation
#14
Rohit Nayak, Steven Huntzicker, Jacques Ohayon, Nancy Carson, Vikram Dogra, Giovanni Schifitto, Marvin M Doyley
It is difficult to produce reliable polar strain elastograms (radial and circumferential) because the center of the carotid artery is typically unknown. Principal strain imaging can overcome this limitation, but suboptimal lateral displacement estimates make this an impractical approach for visualizing mechanical properties within the carotid artery. We hypothesized that compounded plane wave imaging can minimize this problem. To test this hypothesis, we performed (i) simulations with vessels of varying morphology and mechanical behavior (i...
March 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28005559/the-impact-of-blood-pressure-variability-on-coronary-plaque-vulnerability-in-stable-angina-an-analysis-using-optical-coherence-tomography
#15
Rie Aoyama, Hitoshi Takano, Keishi Suzuki, Yoshiaki Kubota, Keisuke Inui, Yukichi Tokita, Wataru Shimizu
BACKGROUND: Blood pressure variability (BPV), especially visit-to-visit BPV, has been reported to be a risk factor for cardiovascular disease. The impact of BPV on coronary plaque vulnerability remains uncertain. The aim of this study was to investigate the relationship between BPV and coronary plaque vulnerability. PATIENTS AND METHODS: From August 2013 to May 2014, 36 patients with both hypertension and stable angina pectoris who underwent a percutaneous coronary intervention guided by frequency-domain optical coherence tomography were investigated retrospectively...
May 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/27998840/quantification-and-characterisation-of-released-plaque-material-during-bioresorbable-vascular-scaffold-implantation-into-right-coronary-artery-lesions-by-multimodality-intracoronary-imaging
#16
Heike A Hildebrandt, Polykarpos C Patsalis, Fadi Al-Rashid, Markus Neuhäuser, Tienush Rassaf, Gerd Heusch, Philipp Kahlert, Petra Kleinbongard
AIMS: We aimed to compare intravascular ultrasound with virtual histology (VH-IVUS), optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS) for their ability to quantify the true amount and characterise the nature of released plaque material during bioresorbable vascular scaffold (BVS) implantation into right coronary artery (RCA) lesions using a distal occlusion and aspiration device. METHODS AND RESULTS: Seventeen patients underwent BVS implantation into the right coronary artery under distal protection with intracoronary imaging using VH-IVUS, OCT and NIRS...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27989887/fibrous-cap-thickness-by-optical%C3%A2-coherence-tomography-in%C3%A2-vivo
#17
Annapoorna S Kini, Yuliya Vengrenyuk, Takahiro Yoshimura, Mitsuaki Matsumura, Jacobo Pena, Usman Baber, Pedro Moreno, Roxana Mehran, Akiko Maehara, Samin Sharma, Jagat Narula
BACKGROUND: Optical coherence tomography (OCT) imaging is considered to be the only imaging modality with sufficient resolution to measure fibrous cap thickness (FCT) in vivo. However, reproducibility of the measurements in vivo has been unsatisfactory. OBJECTIVES: The authors aimed to investigate whether satisfactory reproducibility of FCT measurements by OCT in vivo can be achieved between independent observers. METHODS: One hundred seventy OCT pullbacks were analyzed by 2 independent observers with intravascular imaging expertise in accordance with current guidelines to assess the interobserver variability of FCT measurement by intraclass correlation coefficient (ICC)...
February 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27989886/intracoronary-imaging-cholesterol-efflux-and-transcriptomes-after-intensive%C3%A2-statin%C3%A2-treatment-the-yellow-ii-study
#18
Annapoorna S Kini, Yuliya Vengrenyuk, Khader Shameer, Akiko Maehara, Meerarani Purushothaman, Takahiro Yoshimura, Mitsuaki Matsumura, Melissa Aquino, Nezam Haider, Kipp W Johnson, Ben Readhead, Brian A Kidd, Jonathan E Feig, Prakash Krishnan, Joseph Sweeny, Mahajan Milind, Pedro Moreno, Roxana Mehran, Jason C Kovacic, Usman Baber, Joel T Dudley, Jagat Narula, Samin Sharma
BACKGROUND: Despite extensive evidence demonstrating the beneficial effects of statins on clinical outcomes, the mechanisms underlying these effects remain elusive. OBJECTIVES: This study assessed changes in plaque morphology using intravascular imaging, with a comprehensive evaluation of cholesterol efflux capacity (CEC) and peripheral blood mononuclear cell (PBMC) transcriptomics in patients receiving high-dose statin therapy. METHODS: In a prospective study, 85 patients with stable coronary artery disease underwent percutaneous coronary intervention for a culprit lesion, followed by intracoronary multimodality imaging, including optical coherence tomography (OCT) of an obstructive nonculprit lesion...
February 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27973330/three-dimensional-volumetric-assessment-of-coronary-artery-calcification-in-patients-with-stable-coronary-artery-disease-by-oct
#19
Parasuram Krishnamoorthy, Yuliya Vengrenyuk, Hiroshi Ueda, Takahiro Yoshimura, Jacobo Pena, Sadako Motoyama, Usman Baber, Choudhury Hasan, Srinivas Kesanakurthy, Joseph M Sweeny, Samin K Sharma, Jagat Narula, Jason C Kovacic, Annapoorna S Kini
AIMS: There is a lack of reliable technique to quantify coronary artery calcification (CAC). Hence, we used Optical Coherence Tomography (OCT) to quantitate 3- dimensional CAC volume to examine its association with plaque characteristics. METHODS AND RESULTS: A total of 250 patients with stable angina undergoing OCT imaging before PCI were included. CAC volume was calculated from every frame of the culprit lesion and divided into tertiles (low, intermediate and high)...
December 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27818566/overexpression-of-prolyl-4-hydroxylase-%C3%AE-1-stabilizes-but-increases-shear-stress-induced-atherosclerotic-plaque-in-apolipoprotein-e-deficient-mice
#20
Xiao-Qing Cao, Xin-Xin Liu, Meng-Meng Li, Yu Zhang, Liang Chen, Lin Wang, Ming-Xue Di, Mei Zhang
The rupture and erosion of atherosclerotic plaque can induce coronary thrombosis. Prolyl-4-hydroxylase (P4H) plays a central role in the synthesis of all known types of collagens, which are the most abundant constituent of the extracellular matrix in atherosclerotic plaque. The pathogenesis of atherosclerosis is thought to be in part caused by shear stress. In this study, we aimed to investigate a relationship between P4Hα1 and shear stress-induced atherosclerotic plaque. Carotid arteries of ApoE-/- mice were exposed to low and oscillatory shear stress conditions by the placement of a shear stress cast for 2 weeks; we divided 60 male ApoE-/- mice into three groups for treatments with saline (mock) (n = 20), empty lentivirus (lenti-EGFP) (n = 20), and lentivirus-P4Hα1 (lenti-P4Hα1) (n = 20)...
2016: Disease Markers
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