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https://www.readbyqxmd.com/read/29785558/differences-between-first-generation-and-second-generation-drug-eluting-stent-regarding-in-stent-neoatherosclerosis-characteristics-an-optical-coherence-tomography-analysis
#1
Norihiro Kobayashi, Yoshiaki Ito, Masahiro Yamawaki, Motoharu Araki, Tsuyoshi Sakai, Masaru Obokata, Yasunari Sakamoto, Shinsuke Mori, Masakazu Tsutsumi, Masahiro Nauchi, Yohsuke Honda, Takahiro Tokuda, Kenji Makino, Shigemitsu Shirai, Keisuke Hirano
We compared first-generation and second-generation drug-eluting stent (DES) with respect to neoatherosclerosis using optical coherence tomography or optical frequency domain imaging. In-stent restenoses in 102 first-generation and 114 second-generation DES were retrospectively assessed. Neoatherosclerosis, which was defined as the presence of lipid-laden neointima or calcification inside a stent, was observed in 33 (27.2%) and 31 (32.4%) lesions in the first-generation and second-generation DES respectively...
May 21, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29736635/effect-of-distal-thickening-and-stiffening-of-plaque-cap-on-arterial-wall-mechanics
#2
Pengsrorn Chhai, Kyehan Rhee
To investigate the effect of longitudinal variations of cap thickness and tissue properties on wall stresses and strains along the atherosclerotic stenosis, stenotic plaque models (uniformly thick, distally thickened, homogenous, and distally stiffened) were constructed and subjected to computational stress analyses with due consideration of fluid-structure interactions (FSI). The analysis considered three different cap thicknesses-45, 65, and 200 μm-and tissue properties-soft, fibrous, and hard. The maximum peak cap stress (PCS) and strain were observed in the upstream throat section and demonstrated increases of the order of 345 and 190%, respectively, as the cap thickness was reduced from 200 to 45 μm in uniformly thick models...
May 8, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29729869/plasma-trimethylamine-n-oxide-is-associated-with-vulnerable-plaque-characteristics-in-cad-patients-as-assessed-by-optical-coherence-tomography
#3
Xinxin Liu, Zulong Xie, Meng Sun, Xuedong Wang, Ji Li, Jinjin Cui, Fengyun Zhang, Li Yin, Dan Huang, Jingbo Hou, Jinwei Tian, Bo Yu
BACKGROUND: Plaque vulnerability indicates the risk of a cardiovascular event. In the present study, we sought to analyze the relationship between trimethylamine N-oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, and vulnerable plaque characteristics in patients with coronary artery disease (CAD). METHODS: One hundred eighty non-culprit plaques from 90 patients with ACS or with stable angina were assessed by optical coherence tomography (OCT)...
April 28, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29407600/impact-of-cd14-cd16-monocytes-on-coronary-plaque-vulnerability-assessed-by-optical-coherence-tomography-in-coronary-artery-disease-patients
#4
Hiroyuki Yamamoto, Naofumi Yoshida, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Kazuhiko Sakaguchi, Yushi Hirota, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Kouji Kuroda, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Takuo Emoto, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
BACKGROUND AND AIMS: This study examined the impact of CD14++ CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++ CD16+ monocyte levels have been reported to increase cardiovascular events, their impact on coronary plaque vulnerability in coronary artery disease (CAD) patients with or without diabetes mellitus (DM) remains unclear. METHODS: This prospective observational study included 50 consecutive patients with CAD, receiving lipid-lowering therapy and undergoing coronary angiography and OCT...
February 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29382667/inhibiting-integrin-%C3%AE-5-cytoplasmic-domain-signaling-reduces-atherosclerosis-and-promotes-arteriogenesis
#5
Madhusudhan Budatha, Jiasheng Zhang, Zhen W Zhuang, Sanguk Yun, James E Dahlman, Daniel G Anderson, Martin A Schwartz
BACKGROUND: Fibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin receptor α5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which inhibits anti-inflammatory cyclic adenosine monophosphate and protein kinase A. Replacing the α5 cytoplasmic domain with that of α2 resulted in smaller atherosclerotic plaques. Here, we further assessed plaque phenotype and compensatory vascular remodeling in this model...
January 30, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29374937/-optical-coherence-tomographic-analysis-of-in-stent-neoatherosclerosis-in-lesions-with-restenosis-after-drug-eluting-stent-implantation
#6
Z J Liu, B Shi, C C Deng, G X Xu, R Z Zhao, C Y Shen, Z L Wang, H L Liu
Objective: To explore the imaging characteristics and related influencing factors of in-stent neoatherosclerosis (ISNA) in patients with restenosis after drug-eluting stent(DES) implantation with optical coherence tomography(OCT). Methods: A total of 25 cases of coronary heart disease patients(DES placement time ≥8 months) with coronary artery angiography showing DES in-stent restenosis (ISR) in Zunyi medical college affiliated hospital from July 2013 to December 2015 were included in this study and patient's data were retrospectively analyzed...
January 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29365568/up-regulation-of-base-excision-repair-gene-8-oxoguanine-glycosylase-1-expression-in-non-st-elevation-myocardial-infarction-and-correlation-with-atherosclerotic-fibrous-cap-thickness
#7
Nikunj Shah, Lisiane Meira, Clara Forrer-Charlier, Michael Mahmoudi
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29359491/does-spotty-calcification-attenuate-the-response-of-nonculprit-plaque-to-statin-therapy-a-serial-optical-coherence-tomography-study
#8
Abigail Afolabi, Irina Mustafina, Linlin Zhao, Lulu Li, Rong Sun, Sining Hu, Shaosong Zhang, Haibo Jia, Guagliumi Guilio, Bo Yu
OBJECTIVES: The aim of this study was to determine if spotty calcification decreases the response of plaque progression to statin therapy. BACKGROUND: Previous studies showed that the presence of spotty calcification is a marker of vulnerable plaque. However, the relationship between spotty calcification and plaque progression is not clear. METHODS: Ninety-six nonculprit lipid-rich plaques in 69 patients who received serial optical coherence tomography (OCT) imaging were included...
February 15, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29344739/what-we-have-learned-from-the-recent-meta-analyses-on-diagnostic-methods-for-atherosclerotic-plaque-regression
#9
REVIEW
Giuseppe Biondi-Zoccai, Simona Mastrangeli, Enrico Romagnoli, Mariangela Peruzzi, Giacomo Frati, Leonardo Roever, Arturo Giordano
PURPOSE OF REVIEW: Atherosclerosis has major morbidity and mortality implications globally. While it has often been considered an irreversible degenerative process, recent evidence provides compelling proof that atherosclerosis can be reversed. Plaque regression is however difficult to appraise and quantify, with competing diagnostic methods available. Given the potential of evidence synthesis to provide clinical guidance, we aimed to review recent meta-analyses on diagnostic methods for atherosclerotic plaque regression...
January 17, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29336364/mechanism-of-chronic-stress-induced-reduced-atherosclerotic-medial-area-and-increased-plaque-instability-in-rabbit-models-of-chronic-stress
#10
Ze-Mou Yu, Xiao-Tao Deng, Ruo-Mei Qi, Lu-Yan Xiao, Chong-Qing Yang, Tao Gong
BACKGROUND: Chronic stress contributes to increased risks of atherosclerotic diseases including heart disease, stroke, and transient ischemic attack. However, its underline mechanisms are poorly understood. This study aimed to elucidate the mechanism via which chronic stress exerts its effect on atherosclerosis (AS). METHODS: Fifty male New Zealand white rabbits were used. Aortic balloon-injury model was applied. Both social stress and physical stress methods were adopted to establish chronic stress models...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29326316/fibronectin-containing-extra-domain-a-induces-plaque-destabilization-in-the-innominate-artery-of-aged-apolipoprotein-e-deficient-mice
#11
Prakash Doddapattar, Manish Jain, Nirav Dhanesha, Steven R Lentz, Anil K Chauhan
OBJECTIVE: Fibronectin containing extra domain A (Fn-EDA) is an endogenous ligand of TLR4 (toll-like receptor 4) and is abundant in the extracellular matrix of advanced atherosclerotic lesions in human and mice. Irrespective of sex, deletion of Fn-EDA reduces early atherosclerosis in apolipoprotein E-deficient (Apoe-/- ) mice. However, the contribution of Fn-EDA in advanced atherosclerosis remains poorly characterized. We determined the contribution of Fn-EDA in advanced atherosclerotic lesions of aged (1-year-old) Apoe-/- mice...
March 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29250534/relation-of-abo-blood-groups-to-the-plaque-characteristic-of-coronary-atherosclerosis
#12
Xingtao Huang, Yongpeng Zou, Lulu Li, Shuyuan Chen, Jingbo Hou, Bo Yu
The ABO blood types related to morphological characteristics of atherosclerosis plaque are not clear. We aimed to evaluate the relationship between ABO blood groups and the coronary plaque characteristic. We retrospectively identified the target lesions in 392 acute coronary syndrome patients who underwent optical coherence tomography examination before stenting. Subjects were divided into different groups according to different blood types. The fibrous cap thickness was significantly thicker in O type compared with non-O type (0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29247510/culprit-plaque-characteristics-in-women-vs-men-with-a-first-st-segment-elevation-myocardial-infarction-in-vivo-optical-coherence-tomography-insights
#13
Rong Sun, Liping Sun, Yandong Fu, Huimin Liu, Maoen Xu, Xuefeng Ren, Huai Yu, Hui Dong, Yang Liu, Yinchun Zhu, Jinwei Tian, Bo Yu
BACKGROUND: It is unclear whether more severe coronary atherosclerosis is a prerequisite to an initial acute coronary event in women vs men. HYPOTHESIS: Women may have more severe coronary atherosclerosis than men in patients with acute coronary event. METHODS: We used intravascular optical coherence tomography (OCT) to evaluate gender differences in culprit-plaque morphology in patients with a first ST-segment elevation myocardial infarction (STEMI)...
December 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29202375/coronary-versus-carotid-artery-plaques-similarities-and-differences-regarding-biomarkers-morphology-and-prognosis
#14
REVIEW
Fragiska Sigala, Evangelos Oikonomou, Alexis S Antonopoulos, George Galyfos, Dimitris Tousoulis
Carotid and coronary artery disease are two major atherosclerotic conditions that have shown an increased prevalence in the last three decades that is associated with high morbidity and mortality. Recent data have revealed that the development of the atherosclerotic plaque-the basic entity in both diseases-may share similar characteristics and mechanisms irrespective of the location site. Even though the biology of atherosclerotic process is similar, there are differences in plaque morphology and characteristics...
December 1, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29195505/type-2-diabetes-mellitus-is-associated-with-a-lower-fibrous-cap-thickness-but-has-no-impact-on-calcification-morphology-an-intracoronary-optical-coherence-tomography-study
#15
Andrea Milzi, Mathias Burgmaier, Kathrin Burgmaier, Martin Hellmich, Nikolaus Marx, Sebastian Reith
BACKGROUND: Patients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque. The minimal fibrous cap thickness (FCT) overlying a necrotic lipid core is an established predictor for plaque rupture. Recently, coronary calcification has emerged as a relevant feature of plaque vulnerability. However, the impact of T2DM on these morphological plaque parameters is largely unexplored. Therefore, this study aimed to compare differences of coronary plaque morphology in patients with and without T2DM with a particular focus on coronary calcification...
December 1, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29150363/development-of-a-3-french-dual-frequency-intravascular-ultrasound-catheter
#16
Chelsea E Munding, Emmanuel Chérin, Isaac Jourard, Jill J Weyers, David E Goertz, Brian K Courtney, F Stuart Foster
Coronary plaque morphology, including plaque size and fibrous cap thickness, is thought to contribute to the risk of plaque rupture and future cardiac events. Dual-frequency intravascular ultrasound has been proposed as a possible technique to visualize both large-scale features and superficial detail of coronary plaque; however, it has not been found to be feasible within the constraints of a clinically functional intravascular ultrasound catheter. In this study, we describe the design and fabrication of a dual-frequency catheter using a bidirectional transducer stack with center frequencies of approximately 30 and 80 MHz...
January 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29131800/qualitative-and-quantitative-evaluation-of-dynamic-changes-in-non-culprit-coronary-atherosclerotic-lesion-morphology-a-longitudinal-oct-study
#17
Bu-Chun Zhang, Antonios Karanasos, Muthukaruppan Gnanadesigan, Johannes N van der Sijde, Nienke van Ditzhuijzen, Karen T Witberg, Jurgen Ligthart, Roberto Diletti, Robert-Jan van Geuns, Jouke Dijkstra, Felix Zijlstra, Gijs van Soest, Evelyn Regar
AIMS: There is limited in vivo evidence regarding the temporal evolution of non-culprit coronary plaque morphology. We evaluated changes in non-culprit plaque morphology over time by optical coherence tomography (OCT). METHODS AND RESULTS:  72 patients with 257 non-culprit segments with serial OCT studies were analyzed. Non-culprit 5mm-long coronary segments from the same imaged region were matched between baseline and follow-up. OCT plaque characterization including automated attenuation analysis was performed and changes over a median follow-up of 6...
November 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29109462/intravascular-optical-coherence-tomography-for-characterization-of-atherosclerosis-with-a-1-7-micron-swept-source-laser
#18
Yan Li, Joseph Jing, Emon Heidari, Jiang Zhu, Yueqiao Qu, Zhongping Chen
The main cause of acute coronary events, such as thrombosis, is the rupture of atherosclerotic plaques. Typical intravascular optical coherence tomography (IVOCT) imaging systems that utilize a 1.3 μm swept source laser are often used for identifying fibrous cap thickness of plaques, yet cannot provide adequate depth penetration to resolve the size of the lipid pool. Here, we present a novel  IVOCT system with a 1.7 μm center wavelength swept light source that can readily penetrate deeper into the tissue because of the longer wavelength and allows for better identification of plaques due to the lipid absorption spectrum at 1...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29092845/clinical-predictors-for-lack-of-favorable-vascular-response-to-statin-therapy-in-patients-with-coronary-artery-disease-a-serial-optical-coherence-tomography-study
#19
Yoshiyasu Minami, Zhao Wang, Aaron D Aguirre, Daniel S Ong, Chong-Jin Kim, Shiro Uemura, Tsunenari Soeda, Hang Lee, James Fujimoto, Ik-Kyung Jang
BACKGROUND: Previous studies have demonstrated that statin therapy improves cardiac outcomes, probably by stabilizing thin-cap fibroatheroma in patients with coronary artery disease. However, major adverse cardiac events still occur in some patients, despite statin therapy. The aim of this study is to identify clinical predictors for the lack of a favorable vascular response to statin therapy in patients with coronary artery disease. METHODS AND RESULTS: A total of 140 nonculprit plaques from 84 patients with coronary artery disease who were treated with a statin and had serial optical coherence tomography imaging (median interval, 6...
November 1, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29089340/genetic-variation-at-the-adamts7-locus-is-associated-with-reduced-severity-of-coronary-artery-disease
#20
Kenneth Chan, Xiangyuan Pu, Pratik Sandesara, Robin N Poston, Iain A Simpson, Arshed A Quyyumi, Shu Ye, Riyaz S Patel
BACKGROUND: Genome-wide association studies identified ADAMTS7 as a risk locus for coronary artery disease (CAD). Functional studies suggest that ADAMTS7 may promote cellular processes in atherosclerosis. We sought to examine the association between genetic variation at ADAMTS7 and measures of atherosclerosis using histological, angiographic, and clinical outcomes data. METHODS AND RESULTS: The lead CAD-associated single-nucleotide polymorphism rs3825807 at the ADAMTS7 locus was genotyped...
October 31, 2017: Journal of the American Heart Association
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