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fibrous cap thickness

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https://www.readbyqxmd.com/read/28059849/is-age-an-important-factor-for-vascular-response-to-statin-therapy-a-serial-optical-coherence-tomography-and-intravascular-ultrasound-study
#1
Jiannan Dai, Jingbo Hou, Lei Xing, Haibo Jia, Sining Hu, Tsunenari Soeda, Yoshiyasu Minami, Daniel Ong, Rocco Vergallo, Shaosong Zhang, Hang Lee, Bo Yu, Ik-Kyung Jang
OBJECTIVE: Age-related structural and functional changes in vessel wall may affect the time course of vascular response to statin therapy. In this study, we sought to compare the response of lipid-rich plaque to statin therapy in elderly versus younger patients using optical coherence tomography and intravascular ultrasound. PATIENTS AND METHODS: Sixty-nine patients who underwent serial optical coherence tomography and intravascular ultrasound at the time point of baseline, 6, and 12 months were divided into two groups according to median age: group A (age<57 years, n=35) and group B (age≥57 years, n=34)...
January 4, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28057387/principal-strain-vascular-elastography-simulation-and-preliminary-clinical-evaluation
#2
Rohit Nayak, Steven Huntzicker, Jacques Ohayon, Nancy Carson, Vikram Dogra, Giovanni Schifitto, Marvin M Doyley
It is difficult to produce reliable polar strain elastograms (radial and circumferential) because the center of the carotid artery is typically unknown. Principal strain imaging can overcome this limitation, but suboptimal lateral displacement estimates make this an impractical approach for visualizing mechanical properties within the carotid artery. We hypothesized that compounded plane wave imaging can minimize this problem. To test this hypothesis, we performed (i) simulations with vessels of varying morphology and mechanical behavior (i...
January 2, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28005559/the-impact-of-blood-pressure-variability-on-coronary-plaque-vulnerability-in-stable-angina-an-analysis-using-optical-coherence-tomography
#3
Rie Aoyama, Hitoshi Takano, Keishi Suzuki, Yoshiaki Kubota, Keisuke Inui, Yukichi Tokita, Wataru Shimizu
BACKGROUND: Blood pressure variability (BPV), especially visit-to-visit BPV, has been reported to be a risk factor for cardiovascular disease. The impact of BPV on coronary plaque vulnerability remains uncertain. The aim of this study was to investigate the relationship between BPV and coronary plaque vulnerability. PATIENTS AND METHODS: From August 2013 to May 2014, 36 patients with both hypertension and stable angina pectoris who underwent a percutaneous coronary intervention guided by frequency-domain optical coherence tomography were investigated retrospectively...
December 21, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27998840/quantification-and-characterisation-of-released-plaque-material-during-bioresorbable-vascular-scaffold-implantation-into-right-coronary-artery-lesions-by-multimodality-intracoronary-imaging
#4
Heike A Hildebrandt, Polykarpos C Patsalis, Fadi Al-Rashid, Markus Neuhäuser, Tienush Rassaf, Gerd Heusch, Philipp Kahlert, Petra Kleinbongard
AIMS: We aimed to compare intravascular ultrasound with virtual histology (VH-IVUS), optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS) for their ability to quantify the true amount and characterise the nature of released plaque material during bioresorbable vascular scaffold (BVS) implantation into right coronary artery (RCA) lesions using a distal occlusion and aspiration device. METHODS AND RESULTS: Seventeen patients underwent BVS implantation into the right coronary artery under distal protection with intracoronary imaging using VH-IVUS, OCT and NIRS...
December 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27989887/assessment-of-fibrous-cap-thickness-by-optical-coherence-tomography-in-vivo-reproducibility-and-standardization
#5
Annapoorna S Kini, Yuliya Vengrenyuk, Takahiro Yoshimura, Mitsuaki Matsumura, Jacobo Pena, Usman Baber, Pedro Moreno, Roxana Mehran, Akiko Maehara, Samin Sharma, Jagat Narula
BACKGROUND: OCT imaging is considered to be the only imaging modality which has resolution sufficient to measure fibrous cap thickness (FCT) in vivo. However, reproducibility of the measurements in vivo has been unsatisfactory. OBJECTIVES: The purpose of this study was to investigate whether a satisfactory reproducibility of FCT measurements by OCT in vivo can be achieved between independent observers. METHODS: One hundred seventy OCT pullbacks were analyzed by two independent observers with intravascular imaging expertise according to the current guidelines to assess the interobserver variability of FCT measurement by intraclass correlation coefficient (ICC)...
October 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27989886/intracoronary-imaging-cholesterol-efflux-and-transcriptomes-after-intensive-statin-treatment-the-yellow-ii-study
#6
Annapoorna S Kini, Yuliya Vengrenyuk, Khader Shameer, Akiko Maehara, Meerarani Purushothaman, Takahiro Yoshimura, Mitsuaki Matsumura, Melissa Aquino, Nezam Haider, Kipp W Johnson, Ben Readhead, Brian A Kidd, Jonathan E Feig, Prakash Krishnan, Joseph Sweeny, Milind Mahajan, Pedro Moreno, Roxana Mehran, Jason C Kovacic, Usman Baber, Joel T Dudley, Jagat Narula, Samin Sharma
BACKGROUND: Despite the extensive evidence for the beneficial effects of statins on clinical outcomes, the mechanisms underlying these effects in remain elusive. OBJECTIVES: To assess the changes in plaque morphology by intravascular imaging with a comprehensive evaluation of cholesterol efflux capacity (CEC) and peripheral blood mononuclear cells (PBMC) transcriptomics in patients receiving high-dose statin therapy. METHODS: In a prospective study, 85 patients with stable multivessel coronary artery disease underwent percutaneous coronary intervention for a culprit lesion followed by intracoronary multi-modality imaging including optical coherence tomography (OCT) of an obstructive non-culprit lesion (NCL)...
October 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27973330/three-dimensional-volumetric-assessment-of-coronary-artery-calcification-in-patients-with-stable-coronary-artery-disease-by-oct
#7
Parasuram Krishnamoorthy, Yuliya Vengrenyuk, Hiroshi Ueda, Takahiro Yoshimura, Jacobo Pena, Sadako Motoyama, Usman Baber, Choudhury Hasan, Srinivas Kesanakurthy, Joseph M Sweeny, Samin K Sharma, Jagat Narula, Jason C Kovacic, Annapoorna S Kini
AIMS: There is a lack of reliable technique to quantify coronary artery calcification (CAC). Hence, we used Optical Coherence Tomography (OCT) to quantitate 3- dimensional CAC volume to examine its association with plaque characteristics. METHODS AND RESULTS: A total of 250 patients with stable angina undergoing OCT imaging before PCI were included. CAC volume was calculated from every frame of the culprit lesion and divided into tertiles (low, intermediate and high)...
December 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27818566/overexpression-of-prolyl-4-hydroxylase-%C3%AE-1-stabilizes-but-increases-shear-stress-induced-atherosclerotic-plaque-in-apolipoprotein-e-deficient-mice
#8
Xiao-Qing Cao, Xin-Xin Liu, Meng-Meng Li, Yu Zhang, Liang Chen, Lin Wang, Ming-Xue Di, Mei Zhang
The rupture and erosion of atherosclerotic plaque can induce coronary thrombosis. Prolyl-4-hydroxylase (P4H) plays a central role in the synthesis of all known types of collagens, which are the most abundant constituent of the extracellular matrix in atherosclerotic plaque. The pathogenesis of atherosclerosis is thought to be in part caused by shear stress. In this study, we aimed to investigate a relationship between P4Hα1 and shear stress-induced atherosclerotic plaque. Carotid arteries of ApoE-/- mice were exposed to low and oscillatory shear stress conditions by the placement of a shear stress cast for 2 weeks; we divided 60 male ApoE-/- mice into three groups for treatments with saline (mock) (n = 20), empty lentivirus (lenti-EGFP) (n = 20), and lentivirus-P4Hα1 (lenti-P4Hα1) (n = 20)...
2016: Disease Markers
https://www.readbyqxmd.com/read/27721214/variability-in-the-measurement-of-minimum-fibrous-cap-thickness-and-reproducibility-of-fibroatheroma-classification-by-optical-coherence-tomography-using-manual-versus-semi-automatic-assessment
#9
Maria D Radu, Kyohei Yamaji, Hector M García-García, Serge Zaugg, Masanori Taniwaki, Konstantinos C Koskinas, Patrick W Serruys, Stephan Windecker, Jouke Dijkstra, Lorenz Räber
AIMS: The minimum fibrous cap thickness (FCT) is considered a major criterion of coronary plaque vulnerability according to autopsy studies. We aimed to assess the reproducibility in the measurement of the optical coherence tomography (OCT)-detected minimum FCT and the agreement in the classification of thin-cap fibroatheroma (TCFA), by a software-based semi-automatic method compared with the manual method. METHODS AND RESULTS: A total of 50 frames with fibroatheromas (FA) were randomly selected from the Integrated Biomarker Imaging Study-4 (IBIS-4)...
October 10, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27686104/validation-of-noninvasive-in-vivo-compound-ultrasound-strain-imaging-using-histologic-plaque-vulnerability-features
#10
Hendrik H G Hansen, Gert Jan de Borst, Michiel L Bots, Frans L Moll, Gerard Pasterkamp, Chris L de Korte
BACKGROUND AND PURPOSE: Carotid plaque rupture is a major cause of stroke. Key issue for risk stratification is early identification of rupture-prone plaques. A noninvasive technique, compound ultrasound strain imaging, was developed providing high-resolution radial deformation/strain images of atherosclerotic plaques. This study aims at in vivo validation of compound ultrasound strain imaging in patients by relating the measured strains to typical features of vulnerable plaques derived from histology after carotid endarterectomy...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27679596/utility-of-near-infrared-spectroscopy-for-detection-of-thin-cap-neoatherosclerosis
#11
Tomasz Roleder, Keyvan Karimi Galougahi, Chee Yang Chin, Navdeep K Bhatti, Emmanouil Brilakis, Tamim M Nazif, Ajay J Kirtane, Dimitri Karmpaliotis, Wojciech Wojakowski, Martin B Leon, Gary S Mintz, Akiko Maehara, Gregg W Stone, Ziad A Ali
AIMS: Near-infrared spectroscopy (NIRS) has been employed to assess the composition of the atherosclerotic plaques in native coronary arteries. However, little is known about the detection of neoatherosclerosis by NIRS in in-stent restenosis (ISR). The aim of the study was to assess the relationship between the distribution of lipid determined by NIRS and morphology of ISR on optical coherence tomography (OCT). METHODS AND RESULTS: We performed both NIRS and OCT in 39 drug-eluting stents with ISR...
September 27, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/27644847/effects-of-methotrexate-in-a-rabbit-model-of-in-stent-neoatherosclerosis-an-optical-coherence-tomography-study
#12
Ruoxi Zhang, Shuyuan Chen, Hui Zhang, Qi Liu, Jianpang Xing, Qi Zhao, Yu Wang, Bo Yu, Jingbo Hou
This study used optical coherence tomography (OCT) to investigate the effects of systemic methotrexate, in combination with a drug-eluting stent, on in-stent neoatherosclerosis in a rabbit model. Sirolimus-eluting stents were surgically implanted in the right common carotid arteries of 200 male New Zealand White rabbits; the animals received a high-fat diet, beginning one week before stent implantation. Each animal was randomly assigned to 1 of 4 groups, receiving intravenous injections of either methotrexate (0...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27616880/ticagrelor-promotes-atherosclerotic-plaque-stability-in-a-mouse-model-of-advanced-atherosclerosis
#13
Michael R Preusch, Jonas Rusnak, Kathrin Staudacher, Carolin Mogler, Lorenz Uhlmann, Philipp Sievers, Florian Bea, Hugo A Katus, Erwin Blessing, Ingo Staudacher
OBJECTIVE: There is increasing evidence supporting the role of platelets in atherosclerotic vascular disease. The G-protein-coupled receptor P2Y12 is a central mediator of platelet activation and aggregation but has also been linked to platelet-independent vascular disease. Ticagrelor is an oral P2Y12 antagonist that is used as a standard treatment in patients after acute myocardial infarction. However, the effects of ticagrelor on advanced atherosclerosis have not been investigated. MATERIALS AND METHODS: Twenty-week-old apolipoprotein-E-deficient mice received standard chow or standard chow supplemented with 0...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27590661/statin-induced-improvements-in-vulnerable-plaques-are-attenuated-in-poorly-controlled-diabetic-patients-with-coronary-atherosclerosis-disease-a-serial-optical-coherence-tomography-analysis
#14
Nana Dong, Zulong Xie, Jiannan Dai, Wei Wang, Rong Sun, Yefei Zhan, Meng Sun, Jinwei Tian, Bo Yu
AIMS: The incidence of cardiac events is increased in diabetic patients even after lipid-lowering therapy. This study aimed to compare the statin-induced changes in the characteristics of vulnerable plaques in patients without diabetes mellitus (DM) and in those with better- or poorly controlled DM, measured by optical coherence tomography (OCT). METHODS: This was a retrospective study of 99 non-culprit lipid-rich plaques from 75 patients who underwent intensive OCT imaging examination...
December 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27563025/the-construction-of-three-dimensional-composite-fibrous-macrostructures-with-nanotextures-for-biomedical-applications
#15
Juqing Song, Huichang Gao, Guanglin Zhu, Xiaodong Cao, Xuetao Shi, Yingjun Wang
The development of modern biomedical nanotechnology requires three-dimensional macrostructures with nanotextures to meet the requirements for practical applications in intricate biological systems. Additionally, the restoration and regeneration of some specific body tissues and organs rely on the function of conductive polymers, which can provide electrical cues for cells. In this study, we fabricated three-dimensional composite nanofibre macrostructures of polycaprolactone (PCL) with different concentrations of polyaniline (PANi) by employing an improved electrospinning technology with a specially designed collector...
2016: Biofabrication
https://www.readbyqxmd.com/read/27531933/resolving-lipid-mediators-maresin-1-and-resolvin-d2-prevent-atheroprogression-in-mice
#16
Joana R Viola, Patricia Lemnitzer, Yvonne Jansen, Gergely Csaba, Carla Winter, Carlos Neideck, Carlos Silvestre-Roig, Gunnar Dittmar, Yvonne Döring, Maik Drechsler, Christian Weber, Ralf Zimmer, Nicolas Cenac, Oliver Soehnlein
RATIONALE: Atheroprogression is a consequence of nonresolved inflammation, and currently a comprehensive overview of the mechanisms preventing resolution is missing. However, in acute inflammation, resolution is known to be orchestrated by a switch from inflammatory to resolving lipid mediators. Therefore, we hypothesized that lesional lipid mediator imbalance favors atheroprogression. OBJECTIVE: To understand the lipid mediator balance during atheroprogression and to establish an interventional strategy based on the delivery of resolving lipid mediators...
October 14, 2016: Circulation Research
https://www.readbyqxmd.com/read/27511975/sex-differences-in-nonculprit-coronary-plaque-microstructures-on-frequency-domain-optical-coherence-tomography-in-acute-coronary-syndromes-and-stable-coronary-artery-disease
#17
Yu Kataoka, Rishi Puri, Muhammad Hammadah, Bhanu Duggal, Kiyoko Uno, Samir R Kapadia, E Murat Tuzcu, Steven E Nissen, Peta King, Stephen J Nicholls
BACKGROUND: Numerous reports suggest sex-related differences in atherosclerosis. Frequency-domain optical coherence tomography has enabled visualization of plaque microstructures associated with disease instability. The prevalence of plaque microstructures between sexes has not been characterized. We investigated sex differences in plaque features in patients with coronary artery disease. METHODS AND RESULTS: Nonculprit plaques on frequency-domain optical coherence tomography imaging were compared between men and women with either stable coronary artery disease (n=320) or acute coronary syndromes (n=115)...
August 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27468140/changes-in-coronary-plaque-morphology-in-patients-with-acute-coronary-syndrome-versus-stable-angina-pectoris-after-initiation-of-statin-therapy
#18
Amy L Gin, Rocco Vergallo, Yoshiyasu Minami, Daniel S Ong, Jingbo Hou, Haibo Jia, Tsunenari Soeda, Sining Hu, Shaosong Zhang, Hang Lee, Bo Yu, Ik-Kyung Jang
OBJECTIVES: The aim of this study was to examine coronary plaque morphology after initiation of statins and compare changes in plaque morphology in patients presenting with acute coronary syndrome (ACS) versus stable angina pectoris (SAP). BACKGROUND: ACS is associated with a pan-inflammatory state, and intraplaque features of inflammation correlate with coronary plaque progression. Statins have known anti-inflammatory properties that may contribute toward their beneficial cardiovascular effects...
July 27, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27465665/treatment-with-the-gpr55-antagonist-cid16020046-increases-neutrophil-activation-in-mouse-atherogenesis
#19
Fabrizio Montecucco, Alexander I Bondarenko, Sébastien Lenglet, Fabienne Burger, Fabiana Piscitelli, Federico Carbone, Aline Roth, Luca Liberale, Franco Dallegri, Karim J Brandt, Rodrigo A Fraga-Silva, Nikolaos Stergiopulos, Vincenzo Di Marzo, François Mach
Endocannabinoids modulate atherogenesis by triggering different receptors. Recently, orphan G protein-coupled receptors (GPRs) were suggested to be activated by endocannabinoids, possibly regulating vasorelaxation. Here, we investigated whether GPR55 antagonism with CID16020046 would impact on atherosclerotic size and inflammation in two mouse models of early and more advanced atherogenesis. Eleven-week old ApoE-/- mice were fed either a normal diet ([ND] for 16 weeks) or a high-cholesterol diet ([HD] for 11 weeks), resulting in different degrees of hypercholesterolaemia and size of atherosclerosis...
July 28, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27461211/association-of-global-and-local-low-endothelial-shear-stress-with-high-risk-plaque-using-intracoronary-3d-optical-coherence-tomography-introduction-of-shear-stress-score
#20
Yiannis S Chatzizisis, Konstantinos Toutouzas, Andreas A Giannopoulos, Maria Riga, Antonios P Antoniadis, Yusuke Fujinom, Dimitrios Mitsouras, Vassilis G Koutkias, Grigorios Cheimariotis, Charalampos Doulaverakis, Ioannis Tsampoulatidis, Ioanna Chouvarda, Ioannis Kompatsiaris, Sunao Nakamura, Frank J Rybicki, Nicos Maglaveras, Dimitris Tousoulis, George D Giannoglou
AIMS: The association of low endothelial shear stress (ESS) with high-risk plaque (HRP) has not been thoroughly investigated in humans. We investigated the local ESS and lumen remodelling patterns in HRPs using optical coherence tomography (OCT), developed the shear stress score, and explored its association with the prevalence of HRPs and clinical outcomes. METHODS AND RESULTS: A total of 35 coronary arteries from 30 patients with stable angina or acute coronary syndrome (ACS) were reconstructed with three dimensional (3D) OCT...
July 26, 2016: European Heart Journal Cardiovascular Imaging
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