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https://www.readbyqxmd.com/read/29896195/cholesterol-crystal-mediated-inflammation-is-driven-by-plasma-membrane-destabilization
#1
Fei Shu, Jiahuan Chen, Xiaojie Ma, Yunzhou Fan, Li Yu, Wencheng Zheng, Matthias W Amrein, Tie Xia, Yan Shi
Atherosclerosis is driven by an inflammatory milieu in the walls of artery vessels. Initiated early in life, it progresses to plaque formation and form cell accumulation. A culprit in this cascade is the deposition of cholesterol crystals (CC). The involvement of smaller crystals in the early stage of atherosclerotic changes may be critical to the long-term pathological development. How these small crystals initiate the pro-inflammatory events is under study. We report here an unexpected mechanism that microscopic CC interact with cellular membrane in a phagocytosis-independent manner...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29886715/recent-advances-in-primary-and-secondary-prevention-of-atherosclerotic-stroke
#2
Georgios Tsivgoulis, Apostolos Safouris, Dong-Eog Kim, Andrei V Alexandrov
Atherosclerosis is a major cause of ischemic stroke that can be effectively prevented with appropriate lifestyle modifications and control of cardiovascular risk factors. Medical advances in recent years along with aggressive cardiovascular risk factor modifications have resulted in decreased recurrence rates of atherosclerotic stroke. Non-statin lipid-lowering molecules have recently shown clinical benefit and are recommended for very high-risk patients to reduce their risk of stroke. Aggressive hypertension treatment is crucial to reduce atherosclerotic stroke risk...
May 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29800147/neutrophils-recruited-by-leukotriene-b4-induce-features-of-plaque-destabilization-during-endotoxemia
#3
Marie-Anne Mawhin, Peggy Tilly, Gaia Zirka, Anne-Laure Charles, Farid Slimani, Jean-Luc Vonesch, Jean-Baptiste Michel, Magnus Bäck, Xavier Norel, Jean-Etienne Fabre
Aims: Both leukotrienes and neutrophils have been linked to plaque destabilization. Despite being evoked, the role of leukotriene B4 on neutrophil recruitment to plaques and the concomitant effects of these two actors on plaque stability remain to be proven. Since both actors are elicited during endotoxemia, a condition associated with the risk of cardiovascular events, we investigated whether endotoxemia promotes leukotriene B4-mediated neutrophil infiltration in plaques and explored the roles of leukotriene B4 and neutrophils in plaque destabilization...
May 24, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29781836/relationship-between-left-main-coronary-artery-plaque-burden-and-nonleft-main-coronary-atherosclerosis-results-from-the-prospect-study
#4
Takehisa Shimizu, Gary S Mintz, Bernard De Bruyne, Naim Z Farhat, Shinji Inaba, Yang Cao, Steven P Marso, Giora Weisz, Patrick W Serruys, Gregg W Stone, Akiko Maehara
OBJECTIVES: Whether the severity of left main coronary artery (LMCA) disease reflects LMCA and overall coronary atherosclerotic burden is not known. We aimed to assess nonculprit LMCA disease characteristics and the relationship with atherosclerosis in the rest of the coronary arteries as well as patient outcomes. PATIENTS AND METHODS: In the PROSPECT study, 697 patients with acute coronary syndromes underwent three-vessel gray-scale and radiofrequency intravascular ultrasound after percutaneous coronary intervention...
May 17, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29778864/plaque-morphology-as-predictor-of-late-plaque-events-in-patients-with-asymptomatic-type-2-diabetes-a-long-term-observational-study
#5
David A Halon, Idit Lavi, Ofra Barnett-Griness, Ronen Rubinshtein, Barak Zafrir, Mali Azencot, Basil S Lewis
OBJECTIVES: We used coronary computed tomography angiography (CTA) to determine plaque characteristics predicting individual late plaque events precipitating acute coronary syndromes (ACS) in a cohort of asymptomatic type 2 diabetic patients. BACKGROUND: In patients with coronary artery disease, CTA plaque characteristics may predict mid-term patient events. METHODS: Asymptomatic patients with diabetes 55 to 74 years of age with no history of coronary artery disease (N = 630) underwent baseline 64-slice CTA and detailed plaque level analysis...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29776555/sudden-coronary-death-in-the-young-evidence-of-contractile-phenotype-of-smooth-muscle-cells-in-the-culprit-atherosclerotic-plaque
#6
Stefania Rizzo, Matteo Coen, Antonija Sakic, Monica De Gaspari, Gaetano Thiene, Giulio Gabbiani, Cristina Basso, Marie-Luce Bochaton-Piallat
BACKGROUND: Culprit coronary atherosclerotic plaques (APs) from young sudden cardiac death (SCD) victims are mostly non-atheromatous, i.e., consisting of proliferative smooth muscle cells (SMCs). Coronary vasospasm has been advocated to explain plaque instability in the absence of thrombosis. Our aim was to characterize the SMC phenotype in the intima and media of coronary arteries from young SCD victims. METHODS AND RESULTS: A total of 38 coronary artery segments were studied: (a) 18 APs from young (≤40 years old) SCD patients, (b) 9 APs from old (>40 years old) SCD patients, (c) 11 non-atherosclerotic coronary arteries from young patients (≤40 years old)...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29763476/drug-induced-linear-iga-bullous-dermatosis-in-a-patient-with-a-vancomycin-impregnated-cement-spacer
#7
Kelsie Riemenschneider, Daren A Diiorio, John A Zic, Matthew R Livingood, Jo-David Fine, Jennifer G Powers, Jeffrey P Zwerner, Eric Tkaczyk
Linear IgA bullous dermatosis (LABD) is an autoimmune blistering rash caused by IgA autoantibodies against the epidermal basement membrane zone. It commonly is drug induced, often in association with systemic vancomycin. We report a case of a previously healthy 77-year-old man who developed a diffuse macular rash and hemorrhagic bullae on the left leg 10 days after placement of a vancomycin-impregnated cement spacer (VICS) during a revision knee arthroplasty and initiation of postoperative treatment with intravenous (IV) vancomycin...
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29756000/bullous-fixed-drug-eruption-following-ibuprofen-ingestion
#8
Seyed Amirhossein Fazeli, Morteza Abbasi, Hadi Jalali, Sonia Eskandari, Farzaneh Shamshirgaran, Zahra Dehghani, Reza Golabchifard, Shahram Ghiyasvand, Kaveh Ghannad
Fixed drug eruption (FDE) is a drug reaction involving skin and less commonly mucosal membranes. The common manifestation is localized well-demarcated patches or plaques appeared following receiving of a culprit drug. When re-exposure occurs, the rashes will appear at areas involved in previous episodes. Limited reports on bullous FDE due to ibuprofen have been documented before. Herein, we described an elderly man who experienced multifocal lesions in his oral mucosa, penis, and multiple sites of skin following ibuprofen ingestion confirmed as FDE by pathological studies...
January 2018: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29752069/plaque-distribution-and-characteristics-in-low-grade-middle-cerebral-artery-stenosis-and-its-clinical-relevance-a-3-dimensional-high-resolution-magnetic-resonance-imaging-study
#9
Shan Shan Lu, Song Ge, Chun Qiu Su, Jun Xie, Hai Bin Shi, Xun Ning Hong
OBJECTIVES: The significance of atherosclerotic plaques in the parental artery with low-grade stenosis remains undetermined. We used three-dimensional high-resolution magnetic resonance imaging (3D HR-MRI) to investigate plaque distribution and characteristics of low-grade middle cerebral artery (MCA) stenosis and its clinical relevance with stroke events. METHODS: We retrospectively studied 22 symptomatic patients and 24 asymptomatic patients with low-grade MCA stenosis (<50%)...
May 8, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29746260/confirmed-coronary-spasm-at-the-culprit-vessel-of-plaque-erosion-in-a-patient-with-new-onset-ventricular-fibrillation
#10
Kazuma Tashiro, Hiroyoshi Mori, Hiromoto Sone, Yousuke Takei, Masahiro Sasai, Atsuo Maeda, Tokutada Sato, Hiroshi Suzuki
No abstract text is available yet for this article.
May 9, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29745476/clinical-impact-of-optical-coherence-tomography-findings-on-culprit-plaque-in-acute-coronary-syndrome-the-oct-formidable-study-registry
#11
Mario Iannaccone, Geraud Souteyrand, Giampaolo Niccoli, Massimo Mancone, Gennaro Sardella, Corrado Tamburino, Christian Templin, Sebastiano Gili, Giacomo G Boccuzzi, Fabrizio D'Ascenzo
BACKGROUND: Aim of this study was to evaluate the clinical impact of the culprit plaque features assessed by optical coherence tomography (OCT) in patients with acute coronary syndrome (ACS). METHODS: The OCT-FORMIDABLE register enrolled retrospectively all consecutive patients who perform OCT on culprit plaque in patients with ACS in nine European centres. The primary endpoint was the prevalence of culprit plaque rupture (CPR) in patients experiencing major adverse cardiovascular events (MACEs)...
May 10, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29729869/plasma-trimethylamine-n-oxide-is-associated-with-vulnerable-plaque-characteristics-in-cad-patients-as-assessed-by-optical-coherence-tomography
#12
Xinxin Liu, Zulong Xie, Meng Sun, Xuedong Wang, Ji Li, Jinjin Cui, Fengyun Zhang, Li Yin, Dan Huang, Jingbo Hou, Jinwei Tian, Bo Yu
BACKGROUND: Plaque vulnerability indicates the risk of a cardiovascular event. In the present study, we sought to analyze the relationship between trimethylamine N-oxide (TMAO), a gut microbiota metabolite from dietary phosphatidylcholine, and vulnerable plaque characteristics in patients with coronary artery disease (CAD). METHODS: One hundred eighty non-culprit plaques from 90 patients with ACS or with stable angina were assessed by optical coherence tomography (OCT)...
April 28, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29703635/differences-in-the-association-of-total-versus-local-coronary-artery-calcium-with-acute-coronary-syndrome-and-culprit-lesions-in-patients-with-acute-chest-pain-the-coronary-calcium-paradox
#13
Stefan B Puchner, Thomas Mayrhofer, Jakob Park, Michael T Lu, Ting Liu, Pal Maurovich-Horvat, Khristine Ghemigian, Daniel O Bittner, Jerome L Fleg, James E Udelson, Quynh A Truong, Udo Hoffmann, Maros Ferencik
BACKGROUND AND AIMS: Total coronary artery calcium (CAC) burden is associated with an increased cardiovascular risk, while local CAC may represent stable plaques. We determined differences in relationship of total CAC with acute coronary syndrome (ACS) and local CAC with culprit lesions in patients with suspected ACS. METHODS: We performed computed tomography (CT) for CAC and CT angiography to assess the presence of significant stenosis and high-risk plaque (positive remodeling, low CT attenuation, napkin-ring sign, spotty calcium) in 37 patients with ACS and 223 controls...
April 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29703054/impact-of-von-willebrand-factor-on-coronary-plaque-burden-in-coronary-artery-disease-patients-treated-with-statins
#14
Yuta Kato, Atsushi Iwata, Makito Futami, Motoki Yamashita, Satoshi Imaizumi, Takashi Kuwano, Amane Ike, Makoto Sugihara, Hiroaki Nishikawa, Bo Zhang, Shin'ichiro Yasunaga, Keijiro Saku, Shin-Ichiro Miura
High von Willebrand factor (VWF) levels have been reported to be associated with an increased risk of cardiovascular events. However, the relationship between VWF levels and coronary atherosclerosis in patients with coronary artery disease (CAD) who have already received stain treatment is still unclear. We examined the association between VWF levels and coronary plaque as assessed by intravascular ultrasound (IVUS) in CAD patients treated with statins. Ninety-one CAD patients who underwent percutaneous coronary intervention under IVUS guidance, and who were already receiving statin treatment based on Japanese guidelines, were included...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29696358/impact-of-the-triglyceride-level-on-coronary-plaque-components-in-female-patients-with-coronary-artery-disease-treated-with-statins
#15
Motoki Yamashita, Atsushi Iwata, Yuta Kato, Makito Futami, Satoshi Imaizumi, Takashi Kuwano, Amane Ike, Makoto Sugihara, Hiroaki Nishikawa, Bo Zhang, Shin'ichiro Yasunaga, Keijiro Saku, Shin-Ichiro Miura
Several studies have reported that elevated triglyceride (TG) levels may be more strongly associated with an increased risk of coronary artery disease (CAD) in females than in males. We examined gender differences in the relationship between TG levels and coronary atherosclerosis using integrated backscatter intravascular ultrasound (IB IVUS) in CAD patients treated with statins. Three hundred seventy-eight CAD patients (105 females and 273 males) who underwent percutaneous coronary intervention using IB IVUS, and who were already receiving statin treatment, were included...
April 25, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29678337/relation-of-coronary-culprit-lesion-morphology-determined-by-optical-coherence-tomography-and-cardiac-outcomes-to-serum-uric-acid-levels-in-patients-with-acute-coronary-syndrome
#16
Nobuaki Kobayashi, Noritake Hata, Masafumi Tsurumi, Yusaku Shibata, Hirotake Okazaki, Akihiro Shirakabe, Masamichi Takano, Yoshihiko Seino, Wataru Shimizu
The aims of the present study were to elucidate features of culprit lesion plaque morphology using optical coherence tomography (OCT) in relation to elevated serum uric acid (sUA) levels and to clarify the impact of sUA levels on adverse clinical outcomes in patients with acute coronary syndrome (ACS). Clinical data and outcomes were compared between ACS patients with sUA ≥6 mg/dl (high-sUA; n = 506) and sUA <6.0 mg/dl (low-sUA; n = 608). Angiography and OCT findings were analyzed in patients with preintervention OCT and compared between groups of high-sUA (n = 206) and low-sUA (n = 273)...
July 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29643815/mechanical-characterization-of-the-vessel-wall-by-data-assimilation-of-intravascular-ultrasound-studies
#17
Gonzalo D Maso Talou, Pablo J Blanco, Gonzalo D Ares, Cristiano Guedes Bezerra, Pedro A Lemos, Raúl A Feijóo
Atherosclerotic plaque rupture and erosion are the most important mechanisms underlying the sudden plaque growth, responsible for acute coronary syndromes and even fatal cardiac events. Advances in the understanding of the culprit plaque structure and composition are already reported in the literature, however, there is still much work to be done toward in-vivo plaque visualization and mechanical characterization to assess plaque stability, patient risk, diagnosis and treatment prognosis. In this work, a methodology for the mechanical characterization of the vessel wall plaque and tissues is proposed based on the combination of intravascular ultrasound (IVUS) imaging processing, data assimilation and continuum mechanics models within a high performance computing (HPC) environment...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29622991/tissue-characterization-of-non-culprit-intermediate-coronary-lesions-in-non-st-elevation-acute-coronary-syndromes
#18
Helmy Hassan Elghawaby, Mohamed Ashraf Shawky, Ahmed Hossam Mowafi, Akram Mohamed Abd-Elbary, Farouk Mostafa Faris
Background: Disruption of vulnerable plaques is the most common cause of acute coronary syndromes. Intravascular ultrasound facilitates cross-sectional imaging of coronary arteries. We aimed at using IVUS to investigate the morphology and tissue characteristics of atherosclerotic plaques of non-culprit intermediate coronary lesions in non-ST elevation ACS setting. Methods: IVUS assessment of sixty-one intermediate coronary lesions in twenty-eight patients with the diagnosis of Non ST elevation acute coronary syndromes...
March 2018: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29606297/ultra-rapid-progression-of-coronary-artery-disease-or-undiagnosed-unstable-plaque-a-brief-review-from-a-case-report
#19
REVIEW
Fernando Montenegro Sá, Catarina Ruivo, Luís Graça Santos, Alexandre Antunes, Francisco Campos Soares, José Baptista, João Morais
Coronary artery disease rarely manifests itself in the first decades of life, which explains why this population is underrepresented in clinical studies. The mechanisms and natural history of the disease seem to differ between this population and older patients. Recent studies suggest a more rapid disease progression in youth, presenting more unstable atherosclerotic plaques, although this correlation has yet to be proven. In this paper, we present the case of a 41-year-old man who presented with a non-ST elevation myocardial infarction, with percutaneous coronary intervention of the culprit lesion (70-90% lesion at bifurcation of the circumflex artery with the first marginal obtuse artery and a sub-occlusive lesion of the ramus intermedius)...
March 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29600962/targeting-the-accomplice-to-thwart-the-culprit-a-new-target-for-the-prevention-of-amyloid-deposition
#20
David R Borchelt
Inheritance of the E4 allele of the apolipoprotein E gene (APOE4) substantially increases the risk of developing late-onset Alzheimer disease (AD). A large body of evidence has firmly established a role for apoE in modulating the risk of developing the amyloid plaque pathology that is pathognomonic for AD. In this issue of the JCI, Liao and colleagues discovered that antibodies against a nonlipidated form of apoE4 are highly effective in delaying the deposition of amyloid β (Aβ) peptides in mouse models of AD pathology...
May 1, 2018: Journal of Clinical Investigation
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