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https://www.readbyqxmd.com/read/28068949/plaque-distribution-of-low-grade-basilar-artery-atherosclerosis-and-its-clinical-relevance
#1
Jin Yu, Ming-Li Li, Yu-Yuan Xu, Shi-Wen Wu, Min Lou, Xue-Tao Mu, Feng Feng, Shan Gao, Wei-Hai Xu
BACKGROUND: The underlying pathophysiology of BA distribution is unclear and intriguing. Using high-resolution magnetic resonance imaging (HR-MRI), we sought to explore the plaque distribution of low-grade basilar artery (BA) atherosclerosis and its clinical relevance. METHODS: We retrospectively analyzed the imaging and clinical data of 61 patients with low-grade atherosclerotic BA stenosis (<50%). On HR-MRI, the plaques were categorized based on the involvement of the ventral, dorsal, or lateral sides of BA wall...
January 10, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28035135/complete-revascularization-of-simultaneous-multiple-culprit-lesions-in-a-septuagenarian-with-st-elevation-myocardial-infarction
#2
Ikechukwu A Ifedili, Tamunoinemi Bob-Manuel, Oluwaseyi Bolorunduro, Raza Askari, Uzoma N Ibebuogu
BACKGROUND ST-elevation myocardial infarction (STEMI) is usually caused by rupture of unstable plaque with thrombus formation and abrupt cessation of blood flow through a single coronary artery that is deemed the culprit. The simultaneous thrombotic occlusions of multiple coronary arteries in the setting of STEMI is a rare occurrence with implications for patient management and outcome not fully addressed in the current STEMI guidelines, although more recent studies suggest a benefit of complete revascularization compared to culprit vessel-only treatment in the setting of STEMI...
December 30, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/28030624/pseudomonas-aeruginosa-microcolonies-in-coronary-thrombi-from-patients-with-st-segment-elevation-myocardial-infarction
#3
Gorm Mørk Hansen, Daniel Belstrøm, Martin Nilsson, Steffen Helqvist, Claus Henrik Nielsen, Palle Holmstrup, Tim Tolker-Nielsen, Michael Givskov, Peter Riis Hansen
Chronic infection is associated with an increased risk of atherothrombotic disease and direct bacterial infection of arteries has been suggested to contribute to the development of unstable atherosclerotic plaques. In this study, we examined coronary thrombi obtained in vivo from patients with ST-segment elevation myocardial infarction (STEMI) for the presence of bacterial DNA and bacteria. Aspirated coronary thrombi from 22 patients with STEMI were collected during primary percutaneous coronary intervention and arterial blood control samples were drawn from radial or femoral artery sheaths...
2016: PloS One
https://www.readbyqxmd.com/read/28024654/coronary-computed-tomography-angiography-derived-plaque-quantification-in-patients-with-acute-coronary%C3%A2-syndrome
#4
Christian Tesche, Damiano Caruso, Carlo N De Cecco, Darby C Shuler, Jess D Rames, Moritz H Albrecht, Taylor M Duguay, Akos Varga-Szemes, David Jochheim, Moritz Baquet, Richard R Bayer, Ullrich Ebersberger, Sheldon E Litwin, Salvatore A Chiaramida, Ellen Hoffmann, U Joseph Schoepf
This study investigated the discriminatory value of quantitative atherosclerotic plaque markers derived from coronary computed tomography angiography (cCTA) in patients with first acute coronary syndrome (ACS) compared with patients with stable coronary artery disease (CAD). Forty patients (56.9 ± 9.3 years, 55% men) admitted with their first ACS and Framingham risk score-matched controls with stable CAD were retrospectively analyzed. All patients had undergone cCTA followed by invasive coronary angiography...
December 3, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28013285/not-all-plaque-ruptures-are-born-equal-an-optical-coherence-tomography-study
#5
Giancarla Scalone, Giampaolo Niccoli, Hesham Refaat, Rocco Vergallo, Italo Porto, Antonio Maria Leone, Francesco Burzotta, Domenico D'Amario, Giovanna Liuzzo, Francesco Fracassi, Carlo Trani, Filippo Crea
AIMS: Plaque rupture (PR) represents the most common substrate of coronary thrombosis, in at least 50% of cases. Chronic low grade inflammation is a common background for atherosclerosis development; however, increased plaque inflammation may predispose by itself to PR. In the last decade, studies performed by optical coherence tomography (OCT) have allowed to establish the severity of plaque inflammation by assessing macrophage infiltration (MØI). Our retrospective study aimed at assessing the role of plaque inflammation in PR among patients with acute coronary syndrome (ACS) using OCT...
December 24, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28007741/predictors-and-long-term-clinical-impact-of-acute-stent-malapposition-an-assessment-of-dual-antiplatelet-therapy-with-drug-eluting-stents-adapt-des-intravascular-ultrasound-substudy
#6
Bin Wang, Gary S Mintz, Bernhard Witzenbichler, Cristiano F Souza, D Christopher Metzger, Michael J Rinaldi, Peter L Duffy, Giora Weisz, Thomas D Stuckey, Bruce R Brodie, Mitsuaki Matsumura, Myong-Hwa Yamamoto, Rupa Parvataneni, Ajay J Kirtane, Gregg W Stone, Akiko Maehara
BACKGROUND: The impact of acute stent malapposition (ASM) on long-term clinical outcomes in patients undergoing percutaneous coronary intervention is still controversial. We sought to evaluate predictors and long-term clinical outcomes of ASM. METHODS AND RESULTS: ADAPT-DES (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) was a prospective multicenter study of 8663 patients undergoing percutaneous coronary intervention using drug-eluting stents...
December 22, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27989886/intracoronary-imaging-cholesterol-efflux-and-transcriptomes-after-intensive-statin-treatment-the-yellow-ii-study
#7
Annapoorna S Kini, Yuliya Vengrenyuk, Khader Shameer, Akiko Maehara, Meerarani Purushothaman, Takahiro Yoshimura, Mitsuaki Matsumura, Melissa Aquino, Nezam Haider, Kipp W Johnson, Ben Readhead, Brian A Kidd, Jonathan E Feig, Prakash Krishnan, Joseph Sweeny, Milind Mahajan, Pedro Moreno, Roxana Mehran, Jason C Kovacic, Usman Baber, Joel T Dudley, Jagat Narula, Samin Sharma
BACKGROUND: Despite the extensive evidence for the beneficial effects of statins on clinical outcomes, the mechanisms underlying these effects in remain elusive. OBJECTIVES: To assess the changes in plaque morphology by intravascular imaging with a comprehensive evaluation of cholesterol efflux capacity (CEC) and peripheral blood mononuclear cells (PBMC) transcriptomics in patients receiving high-dose statin therapy. METHODS: In a prospective study, 85 patients with stable multivessel coronary artery disease underwent percutaneous coronary intervention for a culprit lesion followed by intracoronary multi-modality imaging including optical coherence tomography (OCT) of an obstructive non-culprit lesion (NCL)...
October 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27987040/lipid-lowering-therapy-stabilizes-the-complexity-of-non-culprit-plaques-in-human-coronary-artery-a-quantitative-assessment-using-oct-bright-spot-algorithm
#8
Yoshiyasu Minami, Taylor Hoyt, Jennifer E Phipps, Thomas E Milner, Lei Xing, Hang Lee, Bo Yu, Marc D Feldman, Ik-Kyung Jang
To quantitatively evaluate the change of plaque complexity with cholesterol lowering therapy. A total of 44 non-culprit plaques from 30 patients who had serial image acquisition at baseline, 6-months, and 12-months by both optical coherence tomography (OCT) and intravascular ultrasound (IVUS) were included. Patients were treated with atorvastatin 60 mg (AT60, n = 16) or 20 mg (AT20, n = 14). We applied an OCT bright spot algorithm, which identifies a variety of plaque components including macrophages...
December 16, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27973332/limitations-of-oct-in-identifying-and-quantifying-lipid-components-an-in-vivo-comparison-study-with-ivus-nirs
#9
Luca Di Vito, Fabrizio Imola, Laura Gatto, Enrico Romagnoli, Ugo Limbruno, Valeria Marco, Andrea Picchi, Antonio Micari, Mario Albertucci, Francesco Prati
AIMS: We assessed the agreement between IVUS-NIRS and OCT to assess lipid plaques in patients with acute coronary syndromes or stable angina. In addition, the impact of both macrophages and calcifications was investigated. METHODS AND RESULTS: Forty-three patients undergoing both IVUS-NIRS and OCT assessment of the culprit and/or non culprit coronary lesions were enrolled. Cross-sections from lipid plaques, calcified plaques and normal appearing vessel tracts were identified and matched with the two imaging techniques...
December 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27973330/three-dimensional-volumetric-assessment-of-coronary-artery-calcification-in-patients-with-stable-coronary-artery-disease-by-oct
#10
Parasuram Krishnamoorthy, Yuliya Vengrenyuk, Hiroshi Ueda, Takahiro Yoshimura, Jacobo Pena, Sadako Motoyama, Usman Baber, Choudhury Hasan, Srinivas Kesanakurthy, Joseph M Sweeny, Samin K Sharma, Jagat Narula, Jason C Kovacic, Annapoorna S Kini
AIMS: There is a lack of reliable technique to quantify coronary artery calcification (CAC). Hence, we used Optical Coherence Tomography (OCT) to quantitate 3- dimensional CAC volume to examine its association with plaque characteristics. METHODS AND RESULTS: A total of 250 patients with stable angina undergoing OCT imaging before PCI were included. CAC volume was calculated from every frame of the culprit lesion and divided into tertiles (low, intermediate and high)...
December 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27969926/tct-557-impact-of-the-extent-of-circumferential-plaque-on-non-culprit-lesion-related-events-a-prospect-substudy
#11
Kohei Koyama, Gary Mintz, Bjorn Redfors, Patrick Serruys, Bernard De Bruyne, Gregg Stone, Akiko Maehara
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27965297/clinical-impact-of-suboptimal-stenting-and-residual-intrastent-plaque-thrombus-protrusion-in-patients-with-acute-coronary-syndrome-the-cli-opci-acs-substudy-centro-per-la-lotta-contro-l-infarto-optimization-of-percutaneous-coronary-intervention-in-acute-coronary
#12
Francesco Prati, Enrico Romagnoli, Laura Gatto, Alessio La Manna, Francesco Burzotta, Ugo Limbruno, Francesco Versaci, Franco Fabbiocchi, Alessandro Di Giorgio, Valeria Marco, Vito Ramazzotti, Luca Di Vito, Carlo Trani, Italo Porto, Alberto Boi, Luigi Tavazzi, Gary S Mintz
BACKGROUND: Clinical consequences of optical coherence tomographic (OCT) high-definition visualization of plaque/stent structures in acute patients remain undefined. In this retrospective substudy, we assessed the prognostic impact of postprocedural culprit lesion OCT findings in patients with acute coronary syndrome undergoing percutaneous coronary intervention. METHODS AND RESULTS: In the CLI-OPCI (Centro per la Lotta Contro L'Infarto-Optimization of Percutaneous Coronary Intervention) database collecting cases from 5 independent OCT-experienced centers, we retrospectively analyzed postprocedural OCT findings in acute coronary syndrome patients and explored its possible impact (specifically that of residual intrastent plaque/thrombus protrusion) on outcome...
December 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27941711/recurrent-acute-myocardial-infarction-in-a-patient-with-severe-coronary-artery-ectasia-implication-of-antithrombotic-therapy
#13
Tomoko Tomioka, Satoshi Takeuchi, Yoshitaka Ito, Hiroki Shioiri, Jiro Koyama, Kanichi Inoue
BACKGROUND Acute myocardial infarction (AMI) can be caused not only by plaque rupture/erosion, but also by many other mechanisms. Thromboembolism due to atrial fibrillation and coronary thrombosis due to coronary artery ectasia are among the causes. Here we report on a case of recurrent myocardial infarction with coronary artery ectasia. CASE REPORT Our case was a 78-year-old woman with hypertension. Within a one-month interval, she developed AMI twice at the distal portion of her right coronary artery along with coronary artery ectasia...
December 12, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27926579/the-influence-of-coronary-plaque-morphology-assessed-by-optical-coherence-tomography-on-final-microvascular-function-after-stenting-in-patients-with-st-elevation-myocardial-infarction
#14
Giovanni L De Maria, Niket Patel, Mathias Wolfrum, Gregor Fahrni, George Kassimis, Italo Porto, Sam Dawkins, Robin P Choudhury, John C Forfar, Bernard D Prendergast, Keith M Channon, Rajesh K Kharbanda, Hector M Garcia-Garcia, Adrian P Banning
OBJECTIVES: The index of microcirculatory resistance (IMR) provides a reproducible assessment of the status of coronary microvasculature in patients with ST-elevation myocardial infarction (STEMI). Frequency-domain optical coherence tomography (FD-OCT) enables detailed assessment of the morphology of coronary plaque.We sought to determine the influence of the initial culprit coronary plaque anatomy within the infarct-related artery on IMR after stenting in STEMI. PATIENTS AND METHODS: In 25 STEMI patients IMR was measured immediately before and after stent implantation...
December 6, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27893195/photodynamic-therapy-for-the-treatment-of-atherosclerotic-plaque-lost-in-translation
#15
Manish Jain, Matthieu Zellweger, Georges Wagnières, Hubert van den Bergh, Stéphane Cook, Marie-Noelle Giraud
Acute coronary syndromeis a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated that, when an acute coronary event occurs, several non-culprit plaques are in a "vulnerable" state...
November 28, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27867141/sex-differences-in-plaque-characteristics-by-intravascular-imaging-in-patients-with-coronary-artery-disease
#16
Monique E Ten Haaf, Melissa Rijndertse, Jin M Cheng, Sanneke P de Boer, Hector M Garcia Garcia, Robert-Jan M van Geuns, Evelyn Regar, Mattie J Lenzen, Yolande Appelman, Eric Boersma
AIMS: We aimed to study sex differences in coronary plaque burden and plaque composition in patients with coronary artery disease (CAD). METHODS AND RESULTS: Virtual histology intravascular ultrasound (VH-IVUS) and near-infrared spectroscopy (NIRS) imaging of a non-culprit coronary artery was performed in 178 (23.5%) women and 581 men who underwent invasive management of stable angina pectoris (SAP) or acute coronary syndrome (ACS). Women were older and had a worse cardiovascular risk profile than men, but less extended angiographic coronary disease...
November 22, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27855289/potential-contribution-of-the-hepcidin-macrophage-axis-to-plaque-vulnerability-in-acute-myocardial-infarction-in-human
#17
Masahiro Sasai, Yoshitaka Iso, Takuya Mizukami, Naohisa Tomosugi, Takeyuki Sambe, Akira Miyazaki, Hiroshi Suzuki
OBJECTIVES: Hepcidin-25 serves as a key peptide in the regulation of iron homeostasis and inflammation. It remains unknown whether hepcidin-25 plays an adverse role in atherosclerotic diseases. The aim of this study was to investigate whether hepcidin-25 is involved in the pathophysiology of coronary plaque vulnerability. METHODS AND RESULTS: Serum hepcidin-25 levels were quantitatively determined by the LC-MS/MS assay system. Peripheral blood was collected from patients with acute myocardial infarction (MI, n=33) and patients with stable angina pectoris (sCAD, n=19)...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27829644/intra-plaque-hematoma-and-minor-intimal-disruption-detected-by-optical-frequency-domain-imaging-in-a-case-of-acute-coronary-syndrome
#18
Motoki Fukutomi, Nobuhiko Ogata, Masataka Nakano, Kazuomi Kario
A 39-year-old man exhibiting unstable angina was admitted to our hospital, and urgent coronary angiography revealed stenosis of the proximal left anterior descending coronary artery (LAD). A drug eluting stent was implanted at this site, and the patient was discharged uneventfully on the 3rd hospital day. Optical frequency-domain imaging (OFDI) was successful in detecting an intra-plaque hematoma, minor intimal disruption, and thrombus at the culprit lesion in this patient. These observations suggest that this hematoma might be the result of subsequent blood filling into the ruptured plaque through this minor intimal disruption...
December 2, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27818473/plasma-lipoprotein-associated-phospholipase-a2-level-is-an-independent-predictor-of-high-thrombus-burden-in-patients-with-acute-st-segment-elevation-myocardial-infarction
#19
Xiangqi Wu, Yingqiang Zhang, Zhiming Wu, Wei You, Fengshuo Liang, Fei Ye, Shaoliang Chen
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent risk factor for plaque rupture and atherothrombotic events. However, the associations between serum Lp-PLA2 level and thrombus burden in ST-segment elevation myocardial infarction (STEMI) patients remain unknown.We consecutively enrolled 351 STEMI patients who underwent primary percutaneous coronary intervention (pPCI). Patients were assigned to a high thrombus burden (HTB) group (n = 230) and a low thrombus burden (LTB) group (n = 121). Baseline data were recorded during hospital admission...
December 2, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27814787/relation-between-renal-function-and-coronary-plaque-morphology-from-the-assessment-of-dual-antiplatelet-therapy-with-drug-eluting-stents-virtual-histology-intravascular-ultrasound-substudy
#20
Chee Yang Chin, Gary S Mintz, Shigeo Saito, Bernhard Witzenbichler, D Christopher Metzger, Michael J Rinaldi, Ernest L Mazzaferri, Peter L Duffy, Giora Weisz, Thomas D Stuckey, Bruce R Brodie, Claire Litherland, Ajay J Kirtane, Gregg W Stone, Akiko Maehara
We sought to examine the relation between various degrees of renal function and coronary plaque morphology by grayscale and virtual histology intravascular ultrasound (IVUS). ADAPT-DES was a prospective, multicenter registry of 8,582 consecutive patients treated using coronary drug-eluting stents with a prespecified grayscale and virtual histology-IVUS substudy. A lesion-level analysis of study participants was performed by comparing IVUS parameters of culprit and nonculprit lesions across tertiles of estimated creatinine clearance (CrCl)...
January 15, 2017: American Journal of Cardiology
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