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https://www.readbyqxmd.com/read/28731386/impact-of-childhood-adversity-and-out-of-home-placement-for-male-adolescents-who-have-engaged-in-sexually-abusive-behavior
#1
Kelcey L Hall, Jill D Stinson, Michele R Moser
Child maltreatment and household dysfunction have long been linked to delinquency, adult criminality, and sexual offending. However, the association between adverse childhood experiences (ACEs), factors related to out-of-home placement, and the onset of maladaptive behaviors has not thoroughly been explored in adolescents who have engaged in sexually abusive behavior. In the present study, we examined archival records of 120 male youths who have received treatment for sexually abusive behavior. As expected, the male adolescents in this sample have experienced higher rates of ACEs than samples of adult males in the community, adult males who committed sexual offenses, and juvenile justice-involved males as reported in the literature...
January 1, 2017: Child Maltreatment
https://www.readbyqxmd.com/read/28729860/burn-injury-leads-to-increase-in-relative-abundance-of-opportunistic-pathogens-in-the-rat-gastrointestinal-microbiome
#2
Guangtao Huang, Kedai Sun, Supeng Yin, Bei Jiang, Yu Chen, Yali Gong, Yajie Chen, Zichen Yang, Jing Chen, Zhiqiang Yuan, Yizhi Peng
The gastrointestinal microbiome is crucial in human health. With greater than 10 times the cell count of an individual, the gastrointestinal microbiome provides many benefits to the host. It plays an important role in chronic illnesses and immune diseases and also following burns and trauma. This study aimed to determine whether severe burns affect the gastrointestinal microbiome during the early stages of after burn injury and the extent to which the microbiome is disturbed by such burns. We used a rat burn model to investigate any changes occurring in the microbiome after the burn trauma using 16S rRNA sequencing and downstream α-diversity, β-diversity, and taxonomy analysis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28721399/nutritional-and-functional-properties-of-fishmeal-produced-from-fresh-by-products-of-cod-gadus-morhua-l-and-saithe-pollachius-virens
#3
Ola Ween, Janne K Stangeland, Turid S Fylling, Grete Hansen Aas
Fresh by-products of whitefish such as cod and saithe is processed to fishmeal (FM) on-board seagoing Norwegian trawlers. The aim of this study was to document the properties of whitefish FM (WFM) protein with respect to, physicochemical and bioactive properties. Analysis of the proximate composition of representative seasonal WFM batches show that the production is robust without much variance. The mean protein (61.9 ± 1.2), fat (8.9 ± 1.1%), moisture (5 ± 1.2%) and ash content (22.4 ± 0.8%), reflect the use of lean and bony raw-material...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28720969/quantification-of-phenolics-in-syzygium-cumini-seed-and-their-modulatory-role-on-tertiary-butyl-hydrogen-peroxide-induced-oxidative-stress-in-h9c2-cell-lines-and-key-enzymes-in-cardioprotection
#4
H P Syama, A D Arya, R Dhanya, P Nisha, A Sundaresan, E Jacob, P Jayamurthy
The study quantified the major phenolics in different fractions of Syzygium cumini seeds and evaluated their cardioprotective efficacy. Gallic acid, ellagic acid, cinnamic acid, quercetin, syringic acid and ferulic acid were the major polyphenols present in different fractions of Syzygium cumini seeds. The cardioprotective effect of Syzygium cumini seed fractions in modulating angiotensin converting enzyme (ACE), HMG-CoA reductase, LDL oxidation and tertiary butyl hydrogen peroxide (TBHP) induced oxidative stress in H9c2 cardiac cell lines were investigated...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28720491/the-immunomodulatory-effects-of-the-enalapril-in-combination-with-benznidazole-during-acute-and-chronic-phases-of-the-experimental-infection-with-trypanosoma-cruzi
#5
Ana Luisa Junqueira Leite, Guilherme de Paula Costa, Laís Roquete Lopes, Ludmilla Walter Dos Reis Mota, Paula Melo de Abreu Vieira, André Talvani
Trypanosoma cruzi infection triggers a chronic inflammatory process responsible for the alterations in the extracellular matrix and functionality of the heart. The angiotensin converting enzyme (ACE) inhibitors affects T. cruzi in vitro survelence and modulates in vivo some inflammatory mediators. In this study, we investigated the treatment with an ACE inhibitor (Enalapril) and the Benznidazole (Bz) in a single and combination therapies (CT) in C57BL/6 mice infected with VL-10 strain of the T. cruzi. Animals were treated during 20days with different doses of Bz (100, 80, 60mg/kg), Enalapril (25, 20, 15mg/kg) and their CT (100+25; 80+20; 60+15mg/kg) and euthanized at 30° (acute) and at 120° (chronic) days post infection...
July 15, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28719346/virulence-genes-in-biofilm-producer-enterococcus-faecalis-isolates-from-root-canal-infections
#6
M Akbari Aghdam, M H Soroush Barhaghi, M Aghazadeh, F Jafari, M Beomide Hagh, M Haghdoost, M Y Memar, M Ahangarzadeh Rezaee, H Samadi Kafil
Enterococcus faecalis is occurring in opportunistic infections involving the oral cavity. This study aimed to evaluate the presence of E. faecalis virulence genes in dental root canal isolates recovered from advanced chronic periodontitis patients. One hundred E. faecalis isolated from dental root canal during July 2015 to Oct 2016. After analysis of biofilm formation by the semi-quantitative determination in 96-well flat bottom polystyrene plates, the presence of asa, esp, efaA, ace, ebpR, gel and hyl gene were studied by PCR...
May 20, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28717853/radiation-related-heart-disease-after-breast-cancer-radiation-therapy-in-korean-women
#7
Jee Suk Chang, Byung Kyun Ko, Jeoung Won Bae, Jong-Han Yu, Min Ho Park, Yongsik Jung, Ye Won Jeon, Kyung Hwan Kim, Jaeyong Shin, Chang-Ok Suh, Yong Bae Kim
PURPOSE: To study the late cardiac toxicity of breast radiation therapy (RT) in Asian women. METHODS: Female breast cancer patients in Korea who underwent breast conservation surgery followed by RT from 1990-2012 were identified from two large registries at institution and population levels. Cumulative incidences of acute coronary events (ACE) or cardiac mortality were estimated in relation to the laterality of breast cancer using a competing risks analysis. RESULTS: In an analysis of 2577 women from a single institution, 3...
July 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28717364/serum-free-thyroxine-levels-were-associated-with-pulmonary-hypertension-and-pulmonary-artery-systolic-pressure-in-euthyroid-patients-with-coronary-artery-disease
#8
Bingjie Wu, Jingjing Jiang, Minghui Gui, Lin Liu, Qiqige Aleteng, Shanshan Wang, Xiaojing Liu, Yan Ling, Xin Gao
The aim of this study was to evaluate the association between thyroid hormone levels, pulmonary hypertension (PH), and pulmonary artery systolic pressure (PASP) in euthyroid patients with coronary artery disease (CAD). A cross-sectional study was conducted in individuals who underwent coronary angiography and were diagnosed as CAD from March 2013 to November 2013. 811 subjects (185 women and 626 men) were included in this study. PASP was measured by transthoracic Doppler echocardiography. 86 patients were diagnosed as PH and had significantly higher free thyroxine (FT4) levels than those without PH...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28715794/an-introduction-to-the-emergency-department-adult-clinical-escalation-protocol-ed-ace
#9
Eoin Coughlan, Una Geary, Abel Wakai, Ronan O'Sullivan, John Browne, Eilish McAuliffe, Marie Ward, Fiona McDaid, Conor Deasy
PURPOSE OF THE STUDY: This study demonstrates how a participatory action research approach was used to address the challenge of the early and effective detection of the deteriorating patient in the ED setting. The approach enabled a systematic approach to patient monitoring and escalation of care to be developed to address the wide-ranging spectrum of undifferentiated presentations and the phases of ED care from triage to patient admission. This paper presents a longitudinal patient monitoring system, which aims to provide monitoring and escalation of care, where necessary, of adult patients from triage to admission to hospital in a manner that is feasible in the unique ED environment...
November 14, 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28712816/enhanced-startle-reflexivity-during-presentation-of-visual-nurture-cues-in-young-adults-who-experienced-parental-divorce-in-early-childhood
#10
Xenia Hengesch, Mauro F Larra, Johannes B Finke, Terry D Blumenthal, Hartmut Schächinger
Adverse childhood experiences (ACE) may influence stress and affective processing in adulthood. Animal and human studies show enhanced startle reflexivity in adult participants with ACE. This study examined the impact of one of the most common ACE, parental divorce, on startle reflexivity in adulthood. Affective modulation of acoustically-elicited startle eye blink was assessed in a group of 23 young adults with self-reported history of parental divorce, compared to an age- and sex-matched control group (n=18)...
July 13, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28712073/association-between-ace-and-agt-polymorphism-and-cardiovascular-risk-in-acromegalic-patients
#11
Tomris Erbas, Nese Cinar, Selcuk Dagdelen, Arzu Gedik, Hikmet Yorgun, Ugur Canpolat, Giray Kabakci, Mehmet Alikasifoglu
PURPOSE: Whether the renin-angiotensin-aldosterone system plays a role or not in the development of cardiovascular morbidity in acromegaly patients is unknown. The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acromegaly. METHODS: The study included one hundred and seventeen acromegalic patients (62 F/55 M, age: 50.2 ± 12.3 years) and 106 healthy controls (92 F/14 M, age: 41...
July 15, 2017: Pituitary
https://www.readbyqxmd.com/read/28711573/distribution-and-impact-of-comorbidities-on-survival-and-leukemic-transformation-in-myeloproliferative-neoplasm-associated-myelofibrosis-a-retrospective-cohort-study
#12
Justyna Bartoszko, Tony Panzarella, Caroline Jane McNamara, Anthea Lau, Aaron D Schimmer, Andre C Schuh, Hassan Sibai, Dawn Maze, Karen W L Yee, Rebecca Devlin, Vikas Gupta
BACKGROUND: We sought to describe the distribution and impact of comorbidities on outcomes in patients with myelofibrosis, a disease characterized by aberrant bone marrow function with eventual fibrosis. Comorbidities were scored using the Adult Comorbidity Evaluation-27 (ACE-27) and the Hematopoietic Cell Transplant Comorbidity Index (HCT-CI), in which a score ≥ 3 indicates severe comorbidities. PATIENTS AND METHODS: We conducted a retrospective study of 306 patients with a confirmed diagnosis of myelofibrosis...
June 29, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28702801/exposure-to-anisakis-extracts-can-induce-inflammation-on-in-vitro-cultured-human-colonic-cells
#13
Antonio Speciale, Domenico Trombetta, Antonella Saija, Antonio Panebianco, Filippo Giarratana, Graziella Ziino, Paola Lucia Minciullo, Francesco Cimino, Sebastiano Gangemi
Anisakis spp. is a parasitic nematode whose infective third-stage larvae may be found within the flesh of fish species commonly consumed by humans. Thorough cooking or freezing should render the fish safe for consumption; furthermore, marinating solutions containing biocidal agents might have a significant action against Anisakis larvae. Some studies suggest a relationship between some parasitic infections and development of inflammatory bowel disorders, and Anisakis infection might be a risk factor for stomach or colon cancer...
July 12, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28702643/antioxidant-ace-inhibitory-and-antimicrobial-activity-of-fermented-goat-milk-activity-and-physicochemical-property-relationship-of-the-peptide-components
#14
Miriam Moreno-Montoro, Manuel Olalla-Herrera, José Ángel Rufián-Henares, Rafael Giménez Martínez, Beatriz Miralles, Triana Bergillos, Miguel Navarro-Alarcón, Paula Jauregi
Increasing evidence on goat milk and the health benefits of its derived products beyond its nutritional value show its potential as a functional food. In this study, goat milk fractions were tested for their total antioxidant capacity using different methods (ORAC, ABTS, DPPH and FRAP), as well as their angiotensin-I-converting-enzyme inhibitory and antimicrobial (against Escherichia coli and Micrococcus luteus) activities. Different whey fractions (whey, cation exchange membrane permeate P and retentate R) of two fermented skimmed goat milks (ultrafiltered goat milk fermented with the classical starter bacteria or with the classical starter plus the Lactobacillus plantarum C4 probiotic strain) were assessed...
July 13, 2017: Food & Function
https://www.readbyqxmd.com/read/28702260/renin-angiotensin-system-modifying-therapies-are-associated-with-improved-pulmonary-health
#15
Maira Soto, Soo I Bang, Jeff McCombs, Kathleen E Rodgers
BACKGROUND: Pulmonary diseases are often complicated and have diverse etiologies. One common factor is the lack of therapeutics available for these diseases. The goal of this study was to investigate the impact of Renin-Angiotensin System (RAS)-modifying medications on incidence and time to pulmonary complications. METHODS: A retrospective analysis was conducted using claims data from a US commercial insurance company (2007-2013). The study consisted of patients with an emerging hypertension (HTN) diagnosis...
2017: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/28700031/inhibitory-effect-of-the-pseudobrickellia-brasiliensis-spreng-r-m-king-h-rob-aqueous-extract-on-human-lymphocyte-proliferation-and-ifn-%C3%AE-and-tnf-%C3%AE-production-in-vitro
#16
V G Almeida, B A Avelar-Freitas, M G Santos, L A Costa, T J Silva, W F Pereira, M L L Amorim, C F F Grael, L E Gregório, E Rocha-Vieira, G E A Brito-Melo
Pseudobrickellia brasiliensis (Asteraceae) is a plant commonly known as arnica-do-campo and belongs to the native flora of the Brazilian Cerrado. The alcoholic extract of the plant has been used as an anti-inflammatory agent in folk medicine, but the biological mechanism of action has not been elucidated. The present study evaluated the composition of P. brasiliensis aqueous extract and its effects on pro-inflammatory cytokine production and lymphocyte proliferation. The extracts were prepared by sequential maceration of P...
July 10, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28698595/the-gene-variants-of-maternal-fetal-renin-angiotensin-system-in-preeclampsia-a-hybrid-case-parent-mother-control-study
#17
Heng Zhang, Ying-Xue Li, Wei-Jun Peng, Zhi-Wei Li, Chun-Hua Zhang, Hai-Hong Di, Xian-Ping Shen, Jun-Feng Zhu, Wei-Rong Yan
Preeclampsia (PE) is a common pregnancy-related complication, and polymorphisms in angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and angiotensin II type 1 receptor (AT1R) are believed to contribute to PE development. We implemented a hybrid study to investigate the influence of maternal and fetal ACE I/D, ACE G2350A, AGT M235T, AGT T174M, and AT1R A1166C polymorphisms on PE in Han Chinese women. Polymorphisms were genotyped in 1,488 subjects (256 patients experiencing PE, along with their fetuses and partners, and 360 normotensive controls with their fetuses)...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693604/right-median-nerve-electrical-stimulation-for-acute-traumatic-coma-the-asia-coma-electrical-stimulation-trial-study-protocol-for-a-randomised-controlled-trial
#18
Xiang Wu, Chao Zhang, Junfeng Feng, Qing Mao, Guoyi Gao, Jiyao Jiang
BACKGROUND: Traumatic brain injury (TBI) has become the most common cause of death and disability in persons between 15 and 30 years of age, and about 10-15% of patients affected by TBI will end up in a coma. Coma caused by TBI presents a significant challenge to neuroscientists. Right median nerve electrical stimulation has been reported as a simple, inexpensive, non-invasive technique to speed recovery and improve outcomes for traumatic comatose patients. METHODS/DESIGN: This multicentre, prospective, randomised (1:1) controlled trial aims to demonstrate the efficacy and safety of electrical right median nerve stimulation (RMNS) in both accelerating emergence from coma and promoting long-term outcomes...
July 10, 2017: Trials
https://www.readbyqxmd.com/read/28693560/ecophysiological-characterization-and-molecular-differentiation-of-culex-pipiens-forms-diptera-culicidae-in-tunisia
#19
Marwa Beji, Adel Rhim, David Roiz, Ali Bouattour
BACKGROUND: The Culex pipiens complex (Diptera: Culicidae) includes the most widespread mosquito species in the world. Members of this complex are the primary enzootic and epidemic vectors of the West Nile virus (genus Flavivirus) in several countries. The two recognized forms of Cx. pipiens (Linnaeus, 1758) - pipiens and molestus - exhibit behavioral and physiological differences. Natural populations of Cx. pipiens were investigated in several sites in Tunisia to evaluate the ecophysiological and molecular characteristics of their forms...
July 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28693417/ace-an-efficient-and-sensitive-tool-to-detect-insecticide-resistance-associated-mutations-in-insect-acetylcholinesterase-from-rna-seq-data
#20
Dianhao Guo, Jiapeng Luo, Yuenan Zhou, Huamei Xiao, Kang He, Chuanlin Yin, Jianhua Xu, Fei Li
BACKGROUND: Insecticide resistance is a substantial problem in controlling agricultural and medical pests. Detecting target site mutations is crucial to manage insecticide resistance. Though PCR-based methods have been widely used in this field, they are time-consuming and inefficient, and typically have a high false positive rate. Acetylcholinesterases (Ace) is the neural target of the widely used organophosphate (OP) and carbamate insecticides. However, there is not any software available to detect insecticide resistance associated mutations in RNA-Seq data at present...
July 10, 2017: BMC Bioinformatics
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