Ana-Maria Vranceanu, Heena R Manglani, Nathaniel R Choukas, Millan R Kanaya, Ethan Lester, Emily L Zale, Scott R Plotkin, Justin Jordan, Eric Macklin, Jafar Bakhshaie
IMPORTANCE: Neurofibromatoses (NF; NF1, NF2, and schwannomatosis) are hereditary tumor predisposition syndromes with a risk for poor quality of life (QOL) and no evidence-based treatments. OBJECTIVE: To compare a mind-body skills training program, the Relaxation Response Resiliency Program for NF (3RP-NF), with a health education program (Health Enhancement Program for NF; HEP-NF) for improvement of quality of life among adults with NF. DESIGN, SETTING, AND PARTICIPANTS: This single-blind, remote randomized clinical trial randomly assigned 228 English-speaking adults with NF from around the world on a 1:1 basis, stratified by NF type, between October 1, 2017, and January 31, 2021, with the last follow-up February 28, 2022...
June 1, 2023: JAMA Network Open