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https://www.readbyqxmd.com/read/28405636/when-transporters-fail-to-be-transported-how-to-rescue-folding-deficient-slc6-transporters
#1
Sonja Sucic, Ameya Kasture, H M Mazhar Asjad, Carina Kern, Ali El-Kasaby, Michael Freissmuth
The human dopamine transporter (hDAT) belongs to the solute carrier 6 (SLC6) gene family. Point mutations in hDAT (SLC6A3) have been linked to a syndrome of dopamine transporter deficiency or infantile dystonia/parkinsonism. The mutations impair DAT folding, causing retention of variant DATs in the endoplasmic reticulum and subsequently impair transport activity. The folding trajectory of DAT itself is not understood, though many insights have been gained from studies of folding-deficient mutants of the closely related serotonin transporter (SERT); i...
December 30, 2016: Journal of Neurology & Neuromedicine
https://www.readbyqxmd.com/read/28363141/antimony-and-sleep-related-disorders-nhanes-2005-2008
#2
Franco Scinicariello, Melanie C Buser, Aliya G Feroe, Roberta Attanasio
BACKGROUND: Antimony is used as a flame-retardant in textiles and plastics, in semiconductors, pewter, and as pigments in paints, lacquers, glass and pottery. Subacute or chronic antimony poisoning has been reported to cause sleeplessness. The prevalence of short sleep duration (<7h/night) has been reported to be 37.1% in the general US population, and obstructive sleep apnea (OSA) affects 12-28 million US adults. Insufficient sleep and OSA have been linked to the development of several chronic conditions including diabetes, cardiovascular disease, obesity and depression, conditions that pose serious public health threats...
March 28, 2017: Environmental Research
https://www.readbyqxmd.com/read/28286651/trajectories-of-a-set-of-ten-functional-somatic-symptoms-from-adolescence-to-middle-age
#3
Tapio Nummi, Pekka Virtanen, Päivi Leino-Arjas, Anne Hammarström
BACKGROUND: Functional somatic symptoms (FSS), or symptoms without a clear medical explanation are a considerable challenge for health care systems. There is no general consensus as to which symptoms should be regarded functional. Few longitudinal studies on the development of FSS exist and these have mainly been based on the assumption that the factorial structure of a FSS scores variable remains invariant over time. When the analysis covers longer periods of the life course, this may be challenged...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28224277/energy-metabolism-during-endurance-flight-and-the-post-flight-recovery-phase
#4
REVIEW
Susanne Jenni-Eiermann
Migrating birds are known to fly non-stop for thousands of kilometres without food or water intake and at a high metabolic rate thereby relying on energy stores which were built up preceding a flight bout. Hence, from a physiological point of view the metabolism of a migrant has to switch between an active fasting phase during flight and a fuelling phase during stopover. To meet the energetic and water requirements of endurance flight, migratory birds have to store an optimal fuel composition and they have to be able to quickly mobilize and deliver sufficient energy to the working flight muscles...
February 21, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28221187/identification-associated-factors-and-prognosis-of-symptom-clusters-in-taiwanese-patients-with-heart-failure
#5
Tsuey-Yuan Huang, Debra K Moser, Shiow-Li Hwang
BACKGROUND: Patients with heart failure (HF) have multiple distressing symptoms that are associated with poor outcomes. These symptoms do not occur in isolation from each other but likely occur as discrete clusters that may prove helpful to clinicians trying to counsel patients about symptom monitoring and management. Defining common symptom clusters and determining the associations between symptom clusters and outcomes may improve patient management. PURPOSE: The aim of this study was to define symptom clusters and their association with event-free survival in terms of cardiac hospitalization and all-cause mortality in patients with HF...
February 17, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28133972/phenotypes-of-sleeplessness-stressing-the-need-for-psychodiagnostics-in-the-assessment-of-insomnia
#6
Merijn van de Laar, Tim Leufkens, Bart Bakker, Dirk Pevernagie, Sebastiaan Overeem
Insomnia is a too general term for various subtypes that might have different etiologies and therefore require different types of treatment. In this explorative study we used cluster analysis to distinguish different phenotypes in 218 patients with insomnia, taking into account several factors including sleep variables and characteristics related to personality and psychiatric comorbidity. Three clusters emerged from the analysis. The 'moderate insomnia with low psychopathology'-cluster was characterized by relatively normal personality traits, as well as normal levels of anxiety and depressive symptoms in the presence of moderate insomnia severity...
January 30, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28100795/lateral-line-makes-pach%C3%A3-n-cavefish-sleepless
#7
Kathryn Knight
No abstract text is available yet for this article.
January 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28062472/is-having-a-family-member-with-chronic-health-concerns-bad-for-young-people-s-health-cross-sectional-evidence-from-a-national-survey-of-young-australians
#8
Anna K Moffat, Gerry Redmond
OBJECTIVES: Young people's perspectives on the association between having a family member with a chronic health concern (FHC) and their own health are under-researched. This study used young people's reports to assess the prevalence of FHCs and their association with negative health outcomes, with an aim of identifying potential inequalities between marginalised and non-marginalised young people. Family cohesion was examined as a moderating factor. DESIGN: Cross-sectional data from the Australian Child Wellbeing Project survey were used...
January 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28050759/tension-among-women-in-north-india-an-idiom-of-distress-and-a-cultural-syndrome
#9
Lesley Jo Weaver
The existing literature on Indian ethnopsychology has long asserted that somatization is a key aspect of experiences of distress. The study of idioms of distress arose out of work done in India (Nichter in Cult Med Psychiatry 5(4):379-408, 1981), but ironically, little subsequent work has systematically explored idioms of distress in this part of the world. This ethnographic study focused on the term tension (tenśan) and its relation to a cultural syndrome among women in urban North India. This syndrome appears to involve rapid-onset anger, irritation, rumination, and sleeplessness as key symptoms...
March 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/27928829/mapping-the-illness-trajectories-of-insomnia-a-biographical-disruption
#10
Janet M Y Cheung, Bandana Saini, Delwyn J Bartlett, Tracey-Lea Laba, Paul H Mason
The insomnia illness experience can be conceptualised as a form of biographical disruption. Using a critical interpretive phenomenological lens 51 in-depth semi-structured interviews were conducted with patients from specialist sleep and psychology clinics (n = 22) and the general community (n = 29). Patients' narratives revealed key phases of their illness trajectories as they recognise, rethink and respond to insomnia. Their biographical events served as reference points for both patient groups to make sense of their illness experiences as they transitioned from a perceived state of sleeplessness to clinical insomnia...
December 7, 2016: Sociology of Health & Illness
https://www.readbyqxmd.com/read/27835720/a-novel-therapy-for-chronic-sleep-onset-insomnia-a-retrospective-nonrandomized-controlled-study-of-auto-adjusting-dual-level-positive-airway-pressure-technology
#11
Barry Krakow, Victor A Ulibarri, Natalia D McIver, Michael R Nadorff
Objective: Evidence indicates that behavioral or drug therapy may not target underlying pathophysiologic mechanisms for chronic insomnia, possibly due to previously unrecognized high rates (30%-90%) of sleep apnea in chronic insomnia patients. Although treatment studies with positive airway pressure (PAP) demonstrate decreased severity of chronic sleep maintenance insomnia in patients with co-occurring sleep apnea, sleep-onset insomnia has not shown similar results. We hypothesized advanced PAP technology would be associated with decreased sleep-onset insomnia severity in a sample of predominantly psychiatric patients with comorbid sleep apnea...
September 29, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27802855/a-remarkable-case-of-rhabdomyolysis-associated-with-ingestion-of-energy-drink-neon-volt
#12
Praneet S Iyer, Rishitha Yelisetti, Varun Miriyala, Waqas Siddiqui, Anand Kaji
Rhabdomyolysis is defined as a syndrome characterized by muscle necrosis and the release of intracellular muscle constituents into the circulation. We present a case of a 35-year-old male who exercised for 2 h after ingesting energy drink and subsequently presented with rhabdomyolysis. After excluding common and uncommon causes of rhabdomyolysis, we reached the conclusion that the likely cause was the ingestion of energy drink 'NEON VOLT' in a setting of mild dehydration. Increasing physical activity and intense exercise is becoming a trend in many countries, due to its many health-related benefits such as prevention of obesity...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27618928/occupational-hazards-and-health-cost-of-women-cotton-pickers-in-pakistani-punjab
#13
Khuda Bakhsh, Naeem Ahmad, M Asif Kamran, Sarfraz Hassan, Qasir Abbas, Rashed Saeed, M Sadiq Hashmi
BACKGROUND: Farm workers and female cotton pickers are exposed to residual impacts of pesticide use in cotton production, in addition to dust, ultraviolet radiation, etc. Cotton picking causes various health hazards among cotton pickers with varied health cost. A soil bacterium known as Bacillus thuringiensis (Bt) is incorporated in cotton seed through genetic modification and it has resistance against certain bollworms of cotton. So it is considered that Bt cotton fields have less pesticide exposure compared to non-Bt cotton fields...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27594300/-sometimes-it-s-easier-to-write-the-prescription-physician-and-patient-accounts-of-the-reluctant-medicalisation-of-sleeplessness
#14
Mairead Eastin Moloney
The medicalisation of sleep is a rich and growing area of sociological interest. Previous research suggests that medicalisation is occurring within the context of physician office visits, but the inner workings remain unclear. This study is the first to provide perspectives on the office visit interaction from both sleepless patients (n = 27) and the physicians (n = 8) who treat them. Analyses of semi-structured qualitative interviews reveal that sleep-related conversations are typically patient-initiated in routine office visits...
March 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/27594292/cystoisospora-sp-infection-determined-in-immunosuppressed-and-immunocompetent-children-three-cases-report
#15
Zeynep Taş Cengiz, Hasan Yılmaz, Mutalip Çiçek, Yunus Emre Beyhan, Ahmet Cumhur Dülger
The aim of this study was to present three cystoisosporiasis cases diagnosed in pediatric patients of the Yuzuncu Yil University Medical Faculty. In the study, stool samples of the patients were evaluated by native-Lugol and modified acid-fast staining methods in the Parasitology Laboratory. The first case was a 4-year-old male child diagnosed with acute lymphoblastic leukemia (ALL). It was reported that the patient had abdominal pain, and permanent bloody and mucous diarrhea (8-10 times a day) was present for almost 1 week after the beginning of ALL treatment...
June 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27591726/-sleepless-in-seattle-and-drinking-coffee-at-the-annual-scientific-sessions
#16
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/27501590/sleepless-in-america-burning-the-candle-at-both-ends-at-what-cost
#17
EDITORIAL
Kaye K Gaines
No abstract text is available yet for this article.
May 2016: Urologic Nursing
https://www.readbyqxmd.com/read/27489389/manic-symptoms-due-to-methylphenidate-use-in-an-adolescent-with-traumatic-brain-injury
#18
Ozalp Ekinci, Meltem Çobanoğullari Direk, Nuran Ekinci, Cetin Okuyaz
Almost one-fifth of children who sustain a traumatic brain injury (TBI) are under the risk of attention problems after injury. The efficacy and tolerability of methylphenidate (MPH) in children with a history of TBI have not been completely identified. In this case report, MPH-induced manic symptoms in an adolescent with TBI will be summarized. A male patient aged 17 years was admitted with the complaints of attention difficulties on schoolwork and forgetfullness which became evident after TBI. Long-acting MPH was administered with the dose of 18 mg/day for attention problems...
August 31, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27390480/comparison-of-workers-perceptions-toward-work-climate-and-health-symptoms-between-ceramic-and-iron-foundry-workers
#19
Joydeep Majumder, Bhavani S Bagepally, Priyanka Shah, Sanjay Kotadiya, Suresh Yadav, Nibedita Naha
BACKGROUND: Workers exposed to heavy manual material handling (MMH) in a hot working environment succumb to severe physical stress and psychological stress. AIMS: (1) Recognize the heat load at workplaces of ceramic industry and iron industry, and (2) comparatively examine the characteristics of self-reported physiological responses and heat-health perception among these workers. SETTINGS AND DESIGN: Cross-sectional prospective study. MATERIALS AND METHODS: Workplace microclimate in the ceramic industry and iron industry was monitored...
January 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27359128/sleepless-night-restless-mind-effects-of-sleep-deprivation-on-mind-wandering
#20
Jia-Hou Poh, Pearlynne L H Chong, Michael W L Chee
Sleep deprivation can result in degradation of sustained attention through increased distraction by task-irrelevant exogenous stimuli. However, attentional failures in the sleep-deprived state could also be a result of task-unrelated thoughts (TUTs, or mind wandering). Here, well-rested and sleep-deprived participants performed a visual search task under high and low perceptual load conditions. Thought probes were administered at irregular intervals to gauge the frequency of TUTs and level of meta-awareness of mind wandering...
June 30, 2016: Journal of Experimental Psychology. General
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