keyword
MENU ▼
Read by QxMD icon Read
search

New pharmaceutical product

keyword
https://www.readbyqxmd.com/read/27914793/challenges-in-translational-development-of-pharmaceutical-cocrystals
#1
Dnyaneshwar P Kale, Sandeep S Zode, Arvind K Bansal
The last 2 decades have witnessed increased research in the area of cocrystals resulting in deeper scientific understanding, increase in intellectual property landscape, and evolution in the regulatory environment. Pharmaceutical cocrystals have received significant attention as a new solid form on account of their ability to modulate poor physicochemical properties of drug molecules. However, pharmaceutical development of cocrystals could be challenging, thus limiting their translation into viable drug products...
November 30, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27913218/methylotrophic-yeast-pichia-pastoris-as-a-chassis-organism-for-polyketide-synthesis-via-the-full-citrinin-biosynthetic-pathway
#2
Ying Xue, Chuixing Kong, Wei Shen, Chenxiao Bai, Yanna Ren, Xiangshan Zhou, Yuanxing Zhang, Menghao Cai
With the rapid development of synthetic biology, exploring various chassis organisms has become necessary to improve the heterologous biosynthesis of natural products and pharmaceuticals. In this study, we tested the potential of the industrial methylotrophic yeast strain Pichia pastoris for the heterologous synthesis of polyketides. A recombinant P. pastoris GS-pksCT-npgA carrying the Monascus purpureus citrinin polyketide synthase gene pksCT and the Aspergillus nidulans phosphopantetheinyl transferase gene npgA was constructed...
November 29, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27908928/development-and-validation-of-a-normal-phase-chiral-hplc-method-for-analysis-of-afoxolaner-using-a-chiralpak%C3%A2-ad-3-column
#3
Jinyou Zhuang, Satish Kumar, Abu Rustum
Afoxolaner is a new antiparasitic molecule from the isoxazoline family that acts on the insect acarine gamma-aminobutyric acid and glutamate receptors. Isoxazoline family of compounds has been employed as active pharmaceutical ingredient in drug products prescribed for control of fleas and ticks in dogs. Afoxolaner with a chiral center at isoxazoline ring exists as a racemic mixture. A normal phase chiral high performance liquid chromatography analytical method has been developed to verify that afoxolaner is a racemic mixture as demonstrated by specific rotation, as well as to determine enantiomeric purity of single enantiomer samples...
November 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27903430/minimizing-the-risk-of-chemically-reactive-metabolite-formation-of-new-drug-candidates-implications-for-preclinical-drug-design
#4
Andreas Brink, Axel Pähler, Christoph Funk, Franz Schuler, Simone Schadt
Many pharmaceutical companies aim to reduce reactive metabolite formation by chemical modification at early stages of drug discovery. A practice often applied is the detection of stable trapping products of electrophilic intermediates with nucleophilic trapping reagents to guide rational structure-based drug design. This contribution delineates this strategy to minimize the potential for reactive metabolite formation of clinical candidates during preclinical drug optimization, exemplified by the experience at Roche over the past decade...
November 27, 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27901630/emerging-pollutant-treatments-in-wastewater-cases-of-antibiotics-and-hormones
#5
Erika Méndez, Miguel A González-Fuentes, Georgette Rebollar-Perez, Alia Méndez-Albores, Eduardo Torres
Because of the intensive use of pharmaceutical substances in human life, studies on the detection of these chemical compounds and their metabolites as pollutants in water bodies are continuously reported. Some pharmaceutical agents are associated with adverse effects to aquatic life, even at very low concentrations (ng L(-1) to μg L(-1)). For instance, the presence of antibiotics and hormones has been associated with increasing proliferation of antibiotic resistant pathogens and feminization and masculinization of some aquatic organisms...
November 30, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27896497/the-slippery-difficulty-of-ever-containing-drug-resistance-with-current-practices
#6
REVIEW
R Fullybright
It has previously been shown that the rate of drug resistance emergence in medicine is exponential, while we have been producing drugs at a much lower rate. Our ability to successfully contain resistance at any one time is function of how many drugs we have at our disposal to counter new resistances from pathogens. Here, we assess our level of preparedness through a mathematical comparison of the drug manufacture rate by the pharmaceutical industry with the resistance emergence rate in pathogens. To that effect, changes in the rates of growth of the drugs production and resistance emergence processes are computed over multiple time segments and compared...
November 28, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27894973/is-there-nothing-new-under-the-sun-the-influence-of-herbals-and-pharmacopoeias-on-ethnobotanical-traditions-in-albacete-spain
#7
Diego Rivera, Alonso Verde, Concepción Obón, Francisco Alcaraz, Candelaria Moreno, Teresa Egea, José Fajardo, José Antonio Palazón, Arturo Valdés, Maria Adele Signorini, Piero Bruschi
ETHNOPHARMACOLOGICAL RELEVANCE: This paper has two overarching aims: (1) presenting the results of studying the Albacete tariff of medicines of 1526 and (2) broadly analyzing the origin and influences of medicinal traditional knowledge in the region of Albacete, Spain. We use historical and modern literature that may have influenced this knowledge. Our primary goal was to determine the ingredients used in the pharmacy in the 16th century CE in Albacete through the analysis of the tariff, and our secondary goal was to investigate until when ingredients and uses present in pharmacy and herbals persisted in later periods...
November 25, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27892721/social-aspects-in-additive-manufacturing-of-pharmaceutical-products
#8
Johanna Lind, Sofia Kälvemark Sporrong, Susanne Kaae, Jukka Rantanen, Natalja Genina
Additive manufacturing (AM) techniques, such as drug printing, represent a new engineering approach that can implement the concept of personalized medicine via on-demand manufacturing of dosage forms with individually adjusted doses. Implementation of AM principles, such as pharmacoprinting, will challenge the entire drug distribution chain and affect the society at different levels. Areas covered: This work summarizes the concept of personalized medicine and gives an overview of possibilities for monitoring patients' health...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27882840/a-comparison-of-health-care-resource-utilization-and-costs-for-patients-with-allergic-rhinitis-on-single-product-or-free-combination-therapy-of-intranasal-steroids-and-intranasal-antihistamines
#9
Brooke Harrow, Ahmad R Sedaghat, Amanda Caldwell-Tarr, Robert Dufour
BACKGROUND: Allergic rhinitis (AR) is a common condition that can be treated with a number of different therapies. Treatments such as intranasal antihistamines (INAs) and intranasal steroids (INSs) are widely used by AR patients. For some allergy sufferers, a combination of therapies, specifically an INA and an INS, is required to address their symptoms. A new treatment, the formulation of azelastine hydrochloride and fluticasone pro-pionate used as a single spray (MP-AzeFlu), has become available for AR patients who need both types of treatment...
December 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27881618/simultaneous-screening-and-quantification-of-basic-neutral-and-acidic-drugs-in-blood-using-uplc-qtof-ms
#10
Sergei Bidny, Kim Gago, Phuong Chung, Desdemona Albertyn, Daniel Pasin
An analytical method using ultra performance liquid chromatography (UPLC) quadrupole time-of-flight mass spectrometry (QTOF-MS) was developed and validated for the targeted toxicological screening and quantification of commonly used pharmaceuticals and drugs of abuse in postmortem blood using 100 µL sample. It screens for more than 185 drugs and metabolites and quantifies more than 90 drugs. The selected compounds include classes of pharmaceuticals and drugs of abuse such as: antidepressants, antipsychotics, analgesics (including narcotic analgesics), anti-inflammatory drugs, benzodiazepines, beta-blockers, amphetamines, new psychoactive substances (NPS), cocaine and metabolites...
November 22, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27881063/membrane-bioreactors-for-pharmaceutical-applications-optically-pure-enantiomers-production
#11
Emma Piacentini, Rosalinda Mazzei, Lidietta Giorno
In biological systems, recognition at molecular level is governed by chiral interactions. Therefore, optical isomers have very different effect in natural systems. For example, one can have beneficial effect while the other can be very harmful. For these reasons, chiral drugs nowadays are mainly admitted in the optically pure form. Given these requirements, it is clear why demand for chiral drugs has grown dramatically and the single-enantiomer drug segment has become an important part of the overall pharmaceutical market...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27881056/recent-patents-on-proteasome-inhibitors-of-natural-origin
#12
Daniela Correia da Silva, Paula B Andrade, Vera Ribeiro, Patrícia Valentão, David Pereira
BACKGROUND: The proteasome is the major proteolytic site on the eukaryotic cell, degrading most of its short-lived or misfolded polypeptides. The ubiquitin-proteasome pathway has been found to play a fundamental role in the development of several pathologies, from cancer to neurodegenerative diseases, or even retroviral infections. Nature remains a powerful source for the discovery of bioactive compounds. Recently, a number of molecules of natural origin, as well as natural product derivatives, have been described as proteasome inhibitors...
November 23, 2016: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/27873314/characterization-of-a-novel-cellobiose-2-epimerase-from-thermophilic-caldicellulosiruptor-obsidiansis-for-lactulose-production
#13
Qiuming Chen, Roman Levin, Wenli Zhang, Tao Zhang, Bo Jiang, Timo Stressler, Lutz Fischer, Wanmeng Mu
BACKGROUND: Lactulose, a bioactive lactose derivative, has been widely used in food and pharmaceutical industries. Isomerization of lactose to lactulose by cellobiose 2-epimerase (CE) has recently attracted increasing attention, since CE produces lactulose with high yield from lactose as a single substrate. In this study, a new lactulose-producing CE from Caldicellulosiruptor obsidiansis was extensively characterized. RESULTS: The recombinant enzyme exhibited maximal activity at pH 7...
November 21, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27872999/laccase-catalysis-for-the-synthesis-of-bioactive-compounds
#14
REVIEW
Tukayi Kudanga, Blessing Nemadziva, Marilize Le Roes-Hill
The demand for compounds of therapeutic value is increasing mainly because of new applications of bioactive compounds in medicine, pharmaceutical, agricultural, and food industries. This has necessitated the search for cost-effective methods for producing bioactive compounds and therefore the intensification of the search for enzymatic approaches in organic synthesis. Laccase is one of the enzymes that have shown encouraging potential as biocatalysts in the synthesis of bioactive compounds. Laccases are multicopper oxidases with a diverse range of catalytic activities revolving around synthesis and degradative reactions...
November 21, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27872965/novel-technologies-for-optimal-strain-breeding
#15
Michael Bott, Lothar Eggeling
The implementation of a knowledge-based bioeconomy requires the rapid development of highly efficient microbial production strains that are able to convert renewable carbon sources to value-added products, such as bulk and fine chemicals, pharmaceuticals, or proteins at industrial scale. Starting from classical strain breeding by random mutagenesis and screening in the 1950s via rational design by metabolic engineering initiated in the 1970s, a range of powerful new technologies have been developed in the past two decades that can revolutionize future strain engineering...
November 22, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27871050/removal-characteristics-of-don-in-pharmaceutical-wastewater-and-its-influence-on-the-n-nitrosodimethylamine-formation-potential-and-acute-toxicity-of-dom
#16
Haidong Hu, Cong Jiang, Haijun Ma, Lili Ding, Jinju Geng, Ke Xu, Hui Huang, Hongqiang Ren
Previous research has focused on dissolved organic carbon (DOC) as a surrogate for dissolved organic matter (DOM) in pharmaceutical wastewater. Dissolved organic nitrogen (DON) as a part of DOM has received little attention. This study investigated the removal characteristics of DON and its influence on the N-nitrosodimethylamine formation potential (NDMA FP) and acute toxicity of DOM in a full-scale hydrolysis/acidification + anaerobic/anoxic/aerobic + moving bed biofilm reactor (MBBR) process treating pharmaceutical wastewater...
October 5, 2016: Water Research
https://www.readbyqxmd.com/read/27867113/glycosylation-and-antiproliferative-activity-of-hyperglycosylated-ifn-%C3%AE-2-potentiate-hek293-cells-as-biofactories
#17
Agustina Gugliotta, Natalia Ceaglio, Brenda Raud, Guillermina Forno, Laura Mauro, Ricardo Kratje, Marcos Oggero
Both CHO and HEK cells are interesting hosts for the production of biotherapeutics due to their ability to introduce post-translational modifications such as glycosylation. Even though oligosaccharide structures attached to proteins are conserved among eukaryotes, many differences have been found between therapeutic glycoproteins expressed in hamster and human derived cells. In this work, a hyperglycosylated IFN-α2b mutein (IFN4N) was produced in CHO and HEK cell lines and an extensive characterization of their properties was performed...
November 17, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27865713/platensimycin-and-platencin-inspirations-for-chemistry-biology-enzymology-and-medicine
#18
REVIEW
Jeffrey D Rudolf, Liao-Bin Dong, Ben Shen
Natural products have served as the main source of drugs and drug leads, and natural products produced by microorganisms are one of the most prevalent sources of clinical antibiotics. Their unparalleled structural and chemical diversities provide a basis to investigate fundamental biological processes while providing access to a tremendous amount of chemical space. There is a pressing need for novel antibiotics with new mode of actions to combat the growing challenge of multidrug resistant pathogens. This review begins with the pioneering discovery and biological activities of platensimycin (PTM) and platencin (PTN), two antibacterial natural products isolated from Streptomyces platensis...
November 16, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27863984/pharmacy-preparations-back-in-the-limelight-pharmacists-make-up-your-mind
#19
Daan J A Crommelin, Yvonne Bouwman-Boer
In this contribution to the theme issue recognizing prof. Florence's achievements as editor -in-chief of the Int. J. Pharmaceutics, we analyze the future of pharmacy preparations (also known as extemporaneous preparations or compounded products). Pharmacy preparations, long considered as an endangered part of the pharmacy profession on its way to extinction, may be at the brink of a revival. Drivers of this revival are a set of changes related to new clinical concepts and supply shortages. Moreover, new production and IT paradigms are being developed that facilitate the preparation processes and provide the necessary quality management systems...
September 28, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27863674/fused-filament-3d-printing-of-drug-products-microstructure-analysis-and-drug-release-characteristics-of-pva-based-caplets
#20
Alvaro Goyanes, Masanori Kobayashi, Ramón Martínez-Pacheco, Simon Gaisford, Abdul W Basit
Fused deposition modeling (FDM) 3-Dimensional (3D) printing is becoming an increasingly important technology in the pharmaceutical sciences, since it allows the manufacture of personalized oral dosage forms by deposition of thin layers of material. Here, a filament extruder was used to obtain filaments of polyvinyl alcohol (PVA) containing paracetamol or caffeine appropriate for 3D printing. The filaments were used to manufacture caplets for oral administration by FDM 3D printing, with the aim of evaluating the effect of the internal structure (micropore volume), drug loading and composition on drug dissolution behaviour...
November 30, 2016: International Journal of Pharmaceutics
keyword
keyword
81050
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"