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https://www.readbyqxmd.com/read/28810746/new-2016-data-and-statistics-for-global-pharmaceutical-products-and-projections-through-2017
#1
Craig W Lindsley
No abstract text is available yet for this article.
August 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28809931/the-cost-of-entry-an-analysis-of-pharmaceutical-registration-fees-in-low-middle-and-high-income-countries
#2
Steven G Morgan, Brandon Yau, Murray M Lumpkin
BACKGROUND: Advances in pharmaceuticals offer improved health outcomes for a wide range of illnesses, yet medicines are often inaccessible for many patients worldwide. One potential barrier to making medicines available to all is the cost of product registration, the fees for regulatory review and licensing for the sale of medicines beyond the cost of clinical trials, if needed. METHODS AND FINDINGS: We performed a cross-sectional analysis of pharmaceutical registration fees in low-, middle-, and high-income countries...
2017: PloS One
https://www.readbyqxmd.com/read/28809552/characterization-of-2-oxindole-forming-heme-enzyme-mare-expanding-the-functional-diversity-of-the-tryptophan-dioxygenase-superfamily
#3
Yuyang Zhang, Yi Zou, Nelson L Brock, Tingting Huang, Yingxia Lan, Xiaozheng Wang, Zixin Deng, Yi Tang, Shuangjun Lin
3-Substituted 2-oxindoles are important structural motifs found in many biologically active natural products and pharmaceutical lead compounds. Here, we report an enzymatic formation of the 3-substituted 2-oxindoles catalyzed by MarE in the maremycin biosynthetic pathway in Streptomyces sp. B9173. MarE is a homologue of Fe(II)/heme-dependent tryptophan 2,3-dioxygenases (TDOs). Typical TDOs usually catalyze the insertion of two oxygen atoms from O2 into an indole ring to generate N-formylkynurenine (NFK)-like products...
August 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28808332/magnetic-microsphere-based-portable-solid-phase-extraction-device-for-on-site-pre-concentration-of-organics-from-large-volume-water-samples
#4
Zhijian Yao, Qingqing Zhao, Yan Ma, Wei Wang, Qing Zhou, Aimin Li
In this research a new magnetic material called M88 was fully synthetized and characterized for the extraction of pharmaceutical and personal care products in water samples. In addition, a portable prototype of magnetic solidphase extraction (MSPE) device was developed for the onsite preconcentration. The MSPE coupling with high performance liquid chromatography-Diode array detector (HPLC-DAD) method was developed and validated for simultaneous analysis of 11 PPCPs (mefenamic acid, chloroamphenicol, ketoprofen, clofibric acid, indometacin, acetylsalicylic acid, bisphenol A, phenylphenol, gemfibrozil, triclosan, and ibuprofen) in environmental water samples...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808084/glycopyrronium-for-severe-drooling-in-children
#5
(no author information available yet)
Drooling of saliva is common in children with physical, intellectual and learning disability, and with poor neuromuscular coordination and oral control.(1) It can cause skin breakdown, damage to clothes and equipment and psychosocial problems for the child and family. For many years, glycopyrronium has been prescribed off-label using the injection solution given orally or tablets crushed and suspended in water, or as unlicensed products that were imported or manufactured as pharmaceutical specials.(2,3) In January 2017, a glycopyrronium oral solution (Sialanar-Proveca Limited) became available in the UK as the first licensed product for the treatment of severe drooling (sialorrhoea) in children and adolescents aged 3 years and older with chronic neurological disorders...
August 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28802881/recent-topics-of-research-in-the-characterization-and-quality-control-of-biopharmaceuticals-in-japan
#6
Akiko Ishii-Watabe, Hiroko Shibata, Akira Harazono, Masashi Hyuga, Masato Kiyoshi, Satoshi Saitoh, Takafumi Iwura, Tetsuo Torisu, Yukihiro Goda, Susumu Uchiyama
The research and development of next-generation innovative medicines is a prominent interest of both the government and industries in Japan. On June 29, 2017, a kickoff meeting of a new research group focused on the quality issues of biopharmaceuticals was held in Tokyo with Prof. John Carpenter as an invited guest. The group's research focuses mainly on the evaluation and control of protein aggregates/subvisible particles in drug products, but the research topics also include glycan analysis, host-cell protein evaluation, bioassay validation, and analytical quality-by-design...
August 9, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28801043/rapid-identification-of-herbal-compounds-derived-metabolites-using-zebrafish-larvae-as-the-biotransformation-system
#7
Chen Wang, Ying-Hao Yin, Ying-Jie Wei, Zi-Qi Shi, Jian-Qun Liu, Li-Fang Liu, Gui-Zhong Xin
Metabolites derived from herbal compounds are becoming promising sources for discovering new drugs. However, the rapid identification of metabolites from biological matrixes is limited by massive endogenous interference and low abundance of metabolites. Thus, by using zebrafish larvae as the biotransformation system, we herein proposed and validated an integrated strategy for rapid identification of metabolites derived from herbal compounds. Two pivotal steps involved in this strategy are to differentiate metabolites from herbal compounds and match metabolites with their parent compounds...
July 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28792667/highly-enantioselective-production-of-chiral-secondary-alcohols-using-lactobacillus-paracasei-bd101-as-a-new-whole-cell-biocatalyst-and-evaluation-of-their-antimicrobial-effects
#8
Durmuşhan Yılmaz, Engin Şahin, Enes Dertli
Chiral secondary alcohols are valuable intermediates for many important enantiopure pharmaceuticals and biologically active molecules. In this work, we studied asymmetric reduction of aromatic ketones to produce the corresponding chiral secondary alcohols using lactic acid bacteria (LAB) as new biocatalysts. Seven LAB strains were screened for their ability to reduce acetophenones to their corresponding alcohols. Among these strains Lactobacillus paracasei BD101, was found to be the most successful at reducing the ketones to the corresponding alcohols...
August 9, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28778038/application-of-magnetically-immobilized-edible-fungus-for-the-biotransformation-of-panax-notoginseng-saponin-rb1-to-rd-and-rg3
#9
Yuping Zang, Na Guo, Jiao Jiao, Xiqing Wang, Qingyan Gai, Wenjing Xu, Yujie Fu
In this study, we developed a new magnetically immobilized edible fungus for the biotransformation of panax notoginseng saponins Rb1 to Rd and Rg3. The optimum biotransformation conditions were as follows: temperature 32°C, pH 6.5, time 48h and liquid-solid ratio 25:1(mL/g). The yields of Rd and Rg3 reached 41.35±0.12mg/g and 6.35±0.08mg/g which increased 6.97-fold and 3.23-fold to that of untreated control, respectively. Additionally, SEM demonstrated that vestured pits and cell walls of samples were destroyed obviously which was beneficial to the Rb1 biotransformation and target Rd and Rg3 release...
July 27, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28778018/antibacterial-activity-and-antibiotic-modulating-potential-of-the-essential-oil-obtained-from-eugenia-jambolana-in-association-with-led-lights
#10
Nara L F Pereira, Pedro E A Aquino, José G A S Júnior, Janyketchuly S Cristo, Marcos A Vieira Filho, Flávio F Moura, Najla M N Ferreira, Maria K N Silva, Eloiza M Nascimento, Fabrina M A Correia, Francisco A B Cunha, Aline A Boligon, Henrique D M Coutinho, Jaime Ribeiro-Filho, Edinardo F F Matias, Maria I F Guedes
Bacterial resistance has risen as an important health problem with impact on the pharmaceutical industry because many antibiotics have become ineffective, which has affected their commercialization. The Brazilian biodiversity is marked by a vast variety of natural products with significant therapeutic potential, which could bring new perspectives in the treatment of infections caused by resistant microorganisms. The present study aimed to evaluate the antibacterial effect of the essential oil obtained from Eugenia jambolana (EjEO) using the method of microdilution method to determine the Minimum Inhibitory Concentration (MIC)...
July 26, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28774216/3d-printed-drug-delivery-devices-perspectives-and-technical-challenges
#11
Mirja Palo, Jenny Holländer, Jaakko Suominen, Jouko Yliruusi, Niklas Sandler
The technological advancements in the pharmaceutical field are constantly improving and provide various possibilities for meeting the needs of personalized drug therapy. The three-dimensional (3D) printing technology has endless potential in the fabrication of patient-specific drug delivery devices (DDD) and dosage forms as the technological development is progressing. Moreover, the rapidly evolving research on 3D printed DDD has enabled us to determine several challenges related to the manufacturing and marketing of personalized drug delivery systems...
August 4, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28773212/production-of-high-value-nanoparticles-via-biogenic-processes-using-aquacultural-and-horticultural-food-waste
#12
REVIEW
Purabi R Ghosh, Derek Fawcett, Shashi B Sharma, Gerrard E J Poinern
The quantities of organic waste produced globally by aquacultural and horticulture are extremely large and offer an attractive renewable source of biomolecules and bioactive compounds. The availability of such large and diverse sources of waste materials creates a unique opportunity to develop new recycling and food waste utilisation strategies. The aim of this review is to report the current status of research in the emerging field of producing high-value nanoparticles from food waste. Eco-friendly biogenic processes are quite rapid, and are usually carried out at normal room temperature and pressure...
July 25, 2017: Materials
https://www.readbyqxmd.com/read/28769802/cellular-and-molecular-targets-of-menthol-actions
#13
REVIEW
Murat Oz, Eslam G El Nebrisi, Keun-Hang S Yang, Frank C Howarth, Lina T Al Kury
Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions of menthol...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28766104/protein-engineering-and-homologous-expression-of-serratia-marcescens-lipase-for-efficient-synthesis-of-a-pharmaceutically-relevant-chiral-epoxyester
#14
Ke-Cai Chen, Ming-Min Zheng, Jiang Pan, Chun-Xiu Li, Jian-He Xu
The lipase isolated from Serratia marcescens (LipA) is a useful biocatalyst for kinetic resolution of a pharmaceutically relevant epoxyester, (±)-3-(4'-methoxyphenyl) glycidic acid methyl ester [(±)-MPGM], to afford optically pure (-)-MPGM, a key intermediate for the synthesis of diltiazem hydrochloride. Two mutants, LipAL315S and LipAS271F, were identified from the combinatorial saturation mutation library of 14 amino acid residues lining the substrate-binding pocket. LipAL315S, LipAS271F, and their combination LipAL315S/S271F showed 2...
August 1, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28763571/enzymatic-synthesis-of-psilocybin
#15
Janis Fricke, Felix Blei, Dirk Hoffmeister
Psilocybin is the psychotropic tryptamine-derived natural product of Psilocybe carpophores, the so-called "magic mushrooms". Although its structure has been known for 60 years, the enzymatic basis of its biosynthesis has remained obscure. We characterized four psilocybin biosynthesis enzymes. These include i) PsiD which represents a new class of fungal l-tryptophan decarboxylases, ii) PsiK, that catalyzes the phosphotransfer step, iii) the methyl transferase PsiM, catalyzing iterative N-methyltransfer as terminal biosynthetic step, and iv) PsiH, a monooxygenase...
August 1, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28760141/pharmacovigilance-in-israel-tools-processes-and-actions
#16
Eyal Schwartzberg, Matitiahu Berkovitch, Dorit Dil Nahlieli, Joseph Nathan, Einat Gorelik
BACKGROUND: Due to the limited safety data available at the time that a new medication is first marketed, it is essential to continue the collection and monitoring of safety data about adverse drug reactions (ADRs) during the medication's life cycle. This activity, known as pharmacovigilance (PV), is performed worldwide by the pharmaceutical industry as well as by regulatory agencies. In 2012, the Israeli Ministry of Health (MOH) established a Pharmacovigilance and Drug Information Department...
August 1, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28758992/demystifying-traditional-herbal-medicine-with-modern-approach
#17
Fu-Shuang Li, Jing-Ke Weng
Plants have long been recognized for their therapeutic properties. For centuries, indigenous cultures around the world have used traditional herbal medicine to treat a myriad of maladies. By contrast, the rise of the modern pharmaceutical industry in the past century has been based on exploiting individual active compounds with precise modes of action. This surge has yielded highly effective drugs that are widely used in the clinic, including many plant natural products and analogues derived from these products, but has fallen short of delivering effective cures for complex human diseases with complicated causes, such as cancer, diabetes, autoimmune disorders and degenerative diseases...
July 31, 2017: Nature Plants
https://www.readbyqxmd.com/read/28758824/vaccine-development-and-trials-in-low-and-lower-middle-income-countries-key-issues-advances-and-future-opportunities
#18
Amy Grenham, Tonya Villafana
Over the past ten years there has been an increase in the number of vaccine clinical studies conducted in resource limited countries. These include vaccine trials for diseases such as malaria and dengue fever which are endemic to many low and lower-middle income countries. Concurrent with the increase in the number of trials, has been the increase and improvement in local infrastructure to enable the appropriate conduct and oversight of these trials in these settings, including strengthening of local scientific capabilities, ethical and regulatory oversight...
July 31, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28757565/the-pharmaceutical-device-prisma-%C3%A2-skin-promotes-in-vitro-angiogenesis-through-endothelial-to-mesenchymal-transition-during-skin-wound-healing
#19
Raffaella Belvedere, Valentina Bizzarro, Luca Parente, Francesco Petrella, Antonello Petrella
Glycosaminoglycans are polysaccharides of the extracellular matrix supporting skin wound closure. Mesoglycan is a mixture of glycosaminoglycans such as chondroitin-, dermatan-, heparan-sulfate and heparin and is the main component of Prisma(®) Skin, a pharmaceutical device developed by Mediolanum Farmaceutici S.p.a. Here, we show the in vitro effects of this device in the new vessels formation by endothelial cells, since angiogenesis represents a key moment in wound healing. We found a strong increase of migration and invasion rates of these cells treated with mesoglycan and Prisma(®) Skin which mediate the activation of the pathway triggered by CD44 receptor...
July 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28752931/efficacy-assessment-of-an-intramammary-treatment-with-a-new-recrystallized-enrofloxacin-vs-ceftiofur-and-parenteral-enrofloxacin-in-dairy-cows-with-nonsevere-clinical-mastitis
#20
M Viveros, R Lopez-Ordaz, L Gutiérrez, J E Miranda-Calderón, H Sumano
A recrystallized form of enrofloxacin as dehydrate-HCl (enro-C) was assessed for bacteriological and clinical cure efficacies in Holstein-Friesian cows affected of nonsevere clinical mastitis. Treatments were enro-Csusp (n = 81), treated with a pharmaceutical suspension of enro-C/quarter; group enro-Cpd (n = 80) treated as above, but using enro-C powder suspended in water; group CF (n = 65), treated with ceftiofur HCl/quarter; and group enroR (n = 66), treated with standard enrofloxacin solution (5 mg/kg, intramuscular)...
July 28, 2017: Journal of Veterinary Pharmacology and Therapeutics
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