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https://www.readbyqxmd.com/read/29455357/phytochemical-constituents-antioxidant-activity-and-antiproliferative-properties-of-black-red-and-brown-rice-bran
#1
Ali Ghasemzadeh, Mohamad Taghi Karbalaii, Hawa Z E Jaafar, Asmah Rahmat
BACKGROUND: In the recent years, the health benefits of the pigmented rice varieties have reported due to the presence of bioactive compounds. In this study, the phytochemical constituents (total phenolic, flavonoid and anthocyanin content) and individual phenolics and flavonoids of the extracts of sixteen genotypes of pigmented rice bran were evaluated using spectrophotometric and ultra-high performance liquid chromatography method. Antioxidative properties of the free and bound fractions were evaluated using nitric oxide and 1,1-diphenyl-2-picrylhydrazyl scavenging assays...
February 17, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29454282/contaminants-of-emerging-concern-presence-and-adverse-effects-in-fish-a-case-study-in-the-laurentian-great-lakes
#2
Zachary G Jorgenson, Linnea M Thomas, Sarah M Elliott, Jenna E Cavallin, Eric C Randolph, Steven J Choy, David A Alvarez, Jo A Banda, Daniel J Gefell, Kathy E Lee, Edward T Furlong, Heiko L Schoenfuss
The Laurentian Great Lakes are a valuable natural resource that is affected by contaminants of emerging concern (CECs), including sex steroid hormones, personal care products, pharmaceuticals, industrial chemicals, and new generation pesticides. However, little is known about the fate and biological effects of CECs in tributaries to the Great Lakes. In the current study, 16 sites on three rivers in the Great Lakes basin (Fox, Cuyahoga, and Raquette Rivers) were assessed for CEC presence using polar organic chemical integrative samplers (POCIS) and grab water samplers...
February 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29448811/production-of-a-new-mucilage-compound-in-lepidium-sativum-callus-by-optimizing-in-vitro-growth-conditions
#3
Pooran Golkar, Fatemeh Hadian, Mehrana Koohi Dehkordi
The mucilage in Lepidium sativum L. is considered a biologically active compound with diverse medicinal properties. Different explants (hypocotyls and leaf) were transferred to Murashige and Skoog (MS) medium supplemented with twelve different plant growth regulator combinations under two different incubations (light and dark). The best mucilage production from callus (36.76% g g -1 dry weight) was obtained in the MS medium supplemented with 1 mg L -1 of 2, 4-D and 2 mg L -1 of BAP under the light condition...
February 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29445453/the-european-falsified-medicines-directive-in-poland-background-implementation-and-potential-recommendations-for-pharmacists
#4
Piotr Merks, Damian Swieczkowski, Michal Byliniak, Mariola Drozd, Katarzyna Krupa, Milosz Jaguszewski, David A Brindley, Bernard D Naughton
By February 2019, the Polish pharmaceutical industry, community and hospital pharmacies, wholesalers and parallel traders must all comply with the EU-wide Falsified Medicines Directive (FMD) legislation (2011/62/EU), to ensure that no medicinal product is dispensed to a patient without proper tracking and authentication. Here we describe how Poland is complying with the new EU regulations, the actions that have been taken to incorporate the FMD into Polish Pharmaceutical Law and whether or not these actions are sufficient...
January 2018: European Journal of Hospital Pharmacy. Science and Practice
https://www.readbyqxmd.com/read/29445297/managing-severe-pain-and-abuse-potential-the-potential-impact-of-a-new-abuse-deterrent-formulation-oxycodone-naltrexone-extended-release-product
#5
REVIEW
Joseph V Pergolizzi, Robert Taylor, Jo Ann LeQuang, Robert B Raffa
Proper management of severe pain represents one of the most challenging clinical dilemmas. Two equally important goals must be attained: the humanitarian/medical goal to relieve suffering and the societal/legal goal to not contribute to the drug abuse problem. This is an age-old problem, and the prevailing emphasis placed on one or the other goal has resulted in pendulum swings that have resulted in either undertreatment of pain or the current epidemic of misuse and abuse. In an effort to provide efficacious strong pain relievers (opioids) that are more difficult to abuse by the most dangerous routes of administration, pharmaceutical companies are developing products in which the opioid is manufactured in a formulation that is designed to be tamper resistant...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29442628/antibacterial-properties-enhancement-of-layer-by-layer-self-assembled-nanofiltration-membranes
#6
Zhonghua Huang, Mengkun Li, Na Li, Xinyuan Tang, Zhiyu Ouyang
Membrane technology is now being widely used in the field of water treatment for its unique advantages. Layer-by-layer (LbL) self-assembly technique is a convenient and versatile method of modified nanofiltration (NF) membranes fabrication, which can be used to control the thickness and the surface properties of membranes by chemical deposition of polyelectrolytes. Herein, a new kind of composite NF membrane with enhanced antibacterial properties was successfully fabricated through LbL self-assembly method, having polyether sulfone (PES) ultrafiltration (UF) membrane as support layer, N-[(2-hydroxy-3-trimethylammonium)propyl] chloride chitosan (HTCC) and polyacrylic acid (PAA) as active layer, and epichlorohydrin (ECH) as crosslinking reagent...
July 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29438542/discovery-and-development-of-new-antibacterial-drugs-learning-from-experience
#7
Nicole Jackson, Lloyd Czaplewski, Laura J V Piddock
Antibiotic (antibacterial) resistance is a serious global problem and the need for new treatments is urgent. The current antibiotic discovery model is not delivering new agents at a rate that is sufficient to combat present levels of antibiotic resistance. This has led to fears of the arrival of a 'post-antibiotic era'. Scientific difficulties, an unfavourable regulatory climate, multiple company mergers and the low financial returns associated with antibiotic drug development have led to the withdrawal of many pharmaceutical companies from the field...
February 9, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29433249/emulsions-as-delivery-systems-for-gamma-and-delta-tocotrienols-formation-properties-and-simulated-gastrointestinal-fate
#8
Fei Xu, Janam K Pandya, Cheryl Chung, David Julian McClements, Amanda J Kinchla
Tocotrienols have been reported to have stronger bioactivities than tocopherols, and may therefore be suitable as a potent source of vitamin E in functional foods, supplements, and pharmaceuticals. However, their inclusion into new products is hindered by their low water-solubility and oral bioavailability. Oil-in-water emulsions (O/W) could provide an adequate delivery system for these bioactive compounds. Tocotrienols were tested in bulk oil and within O/W conventional emulsions (>10μm) and nanoemulsions (<350nm)...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433245/evaluation-of-radical-scavenging-activity-intestinal-cell-viability-and-antifungal-activity-of-brazilian-propolis-by-product
#9
Lizziane de Francisco, Diana Pinto, Hélen Rosseto, Lucas Toledo, Rafaela Santos, Flávia Tobaldini-Valério, Terezinha Svidzinski, Marcos Bruschi, Bruno Sarmento, M Beatriz P P Oliveira, Francisca Rodrigues
Propolis is a natural adhesive resinous compound produced by honeybees to protect hives from bacteria and fungi, being extremely expensive for food industry. During propolis production, a resinous by-product is formed. This resinous waste is currently undervalued and underexploited. Accordingly, in this study the proximate physical and chemical quality, as well as the antioxidant activity, radical scavenging activity and cell viability of this by-product were evaluated and compared with propolis in order to boost new applications in food and pharmaceutical industries...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433195/biological-properties-and-pharmacological-potential-of-plant-exudates
#10
REVIEW
Irlla Correia Lima Licá, Alexandra Martins Dos Santos Soares, Ludmilla Santos Silva de Mesquita, Sonia Malik
Exudates released from plants, consist of complex mixtures of organic and inorganic molecules that have been used in traditional medicine from several years. They may vary among genera, species or within a genus and mainly include latex, sap, gums, resins, seed or root exudates. Plant exudates are known to possess several biological activities including, antimicrobial, anti-inflammatory, antioxidant, wound healing and anti-nociceptive. Exudates oozed out from plants have also been used as ingredients in medicines, food, perfumes and cosmetics...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29432335/extracellular-matrix-regulation-and-dysregulation-in-exfoliation-syndrome
#11
Matthias Zenkel
Several lines of evidence, such as ultrastructural signs for activated fibrillogenesis and excessive production of elastic microfibrillar components in the anterior segment of the eye and throughout the body, indicate that exfoliation syndrome (XFS) is an elastic microfibrillopathy, leading to the accumulation of an abnormal extracellular fibrillar material (XFM). The upregulation of elastic microfibrillar components is paralleled by the selective upregulation of the cross-linking enzyme lysyl oxidase-like 1 (LOXL1) in the early phase of the disease, suggesting that LOXL1 participates in the stabilization of newly synthesized elastic proteins and finally in the stable accumulation of XFM...
February 9, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29422861/the-turkish-medicines-and-medical-devices-agency-comparison-of-its-registration-process-with-australia-canada-saudi-arabia-and-singapore
#12
Emel Mashaki Ceyhan, Hakki Gürsöz, Ali Alkan, Hacer Coşkun, Oğuzhan Koyuncu, Stuart Walker
Introduction: Regulatory agency comparisons can be of more value and facilitate improvements if conducted among countries with common challenges and similar health agency characteristics. A study was conducted to compare the registration review model used by the Turkish Medicines and Medical Devices Agency (Türkiye Ilaç ve Tibbi Cihaz Kurumu; TITCK) with those of four similar-sized regulatory agencies to identify areas of strength and those requiring further improvement within the TITCK in relation to the review process as well as to assess the level of adherence to good review practices (GRevP) in order to facilitate the TITCK progress toward agency goals...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29417124/edible-oleogels-an-opportunity-for-fat-replacement-in-foods
#13
REVIEW
Artur J Martins, António A Vicente, Rosiane L Cunha, Miguel A Cerqueira
The scientific and industrial communities have been giving great attention to the development of new bio-based materials with potential use in innovative technological applications. Among these materials are the structures with gel-like behavior that can be used in the cosmetic, pharmaceutical and food industries, aiming at controlling the physical properties of the final products. In the past ten years, words like oleogels and organogels have been increasingly used, the existing number of manuscripts and patents being proof of this tendency...
February 8, 2018: Food & Function
https://www.readbyqxmd.com/read/29414002/study-of-the-use-of-axial-viewed-inductively-coupled-plasma-atomic-emission-spectrometry-with-ultrasonic-nebulization-for-the-determination-of-select-elemental-impurities-in-oral-drug-products
#14
James Menoutis, Angela Parisi, Natasha Verma
In efforts to control the potential presence of heavy metals in pharmaceuticals, the United States Pharmacopeia (USP) and International Conference on Harmonization (ICH) have put forth new requirements and guidelines for their control. The new requirements and guidelines establish specific daily exposures (PDE) for 24 heavy metals/elemental impurities (EI) based upon their toxicological properties. USP General Chapter 〈233〉 provides a general reference procedure for preparing pharmaceutical samples for analysis employing microwave assisted digestion (MWAD)...
January 23, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29411056/a-novel-genotoxin-specific-qpcr-array-based-on-the-metabolically-competent-human-heparg%C3%A2-cell-line-as-a-rapid-and-reliable-tool-for-improved-in-vitro-hazard-assessment
#15
Gamze Ates, Birgit Mertens, Anja Heymans, Luc Verschaeve, Dimiter Milushev, Philippe Vanparys, Nancy H C Roosens, Sigrid C J De Keersmaecker, Vera Rogiers, Tatyana Y Doktorova
Although the value of the regulatory accepted batteries for in vitro genotoxicity testing is recognized, they result in a high number of false positives. This has a major impact on society and industries developing novel compounds for pharmaceutical, chemical, and consumer products, as afflicted compounds have to be (prematurely) abandoned or further tested on animals. Using the metabolically competent human HepaRG™ cell line and toxicogenomics approaches, we have developed an upgraded, innovative, and proprietary gene classifier...
February 6, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29410208/trends-in-insect-repellent-formulations-a-review
#16
REVIEW
Melanie Tavares, Márcio Robert Mattos da Silva, Luciana Betzler de Oliveira de Siqueira, Raphaela Aparecida Schuenck Rodrigues, Lolita Bodjolle-d'Almeira, Elisabete Pereira Dos Santos, Eduardo Ricci-Junior
The use of natural and synthetic repellents, marketed in different pharmaceutical forms, is growing in the world due to the emerging vector-borne viral diseases as Dengue, Zika, Chikungunya, Yellow Fever and Malaria. The choice of the ideal formulation will depend on a series of factors to be analyzed: type of repellent active (natural or synthetic), pharmaceutical forms (spray, lotion, cream, gel), action time duration (short or long), environment of exposure and the user (adult, pregnant women, children, newborn)...
February 2, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29409864/starch-nanocapsules-containing-a-novel-neutrophil-elastase-inhibitor-with-improved-pharmaceutical-performance
#17
J Marto, E Ruivo, S D Lucas, L M Gonçaves, S Simões, L F Gouveia, R Felix, R Moreira, H M Ribeiro, A J Almeida
Psoriasis and atopic dermatitis patients show an excessive amount of elastase in peripheral blood neutrophils due to an imbalance between this proteolytic enzyme and its endogenous inhibitors, the search for new human neutrophil elastase (HNE) inhibitors are required. The HNE is an attractive therapeutic target and inhibitors with new molecular architectures have been extensively investigated. In this context a promising novel synthetic human neutrophil elastase inhibitor (ER143) was associated to a starch-based nanoparticulate system (StNC) with improved pharmaceutical performance, using a quality by design approach to support product development and optimization...
January 31, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29407700/occurrence-and-fate-of-emerging-contaminants-in-municipal-wastewater-treatment-plants-from-different-geographical-regions-a-review
#18
REVIEW
Ngoc Han Tran, Martin Reinhard, Karina Yew-Hoong Gin
Emerging contaminants, such as antibiotics, pharmaceuticals, personal care products, hormones, and artificial sweeteners, are recognized as new classes of water contaminants due to their proven or potential adverse effects on aquatic ecosystems and human health. This review provides comprehensive data on the occurrence of 60 emerging contaminants (ECs) in influent, treated effluent, sludge, and biosolids in wastewater treatment plants (WWTPs). In particular, data on the occurrence of ECs in the influents and effluents of WWTPs are systematically summarized and categorized according to geographical regions (Asia, Europe, and North America)...
December 28, 2017: Water Research
https://www.readbyqxmd.com/read/29405558/biocompatible-porous-titanium-scaffolds-produced-using-a-novel-space-holder-technique
#19
Yunhui Chen, Jessica Ellen Frith, Ali Dehghan-Manshadi, Damon Kent, Michael Bermingham, Matthew Dargusch
We describe a new fabrication strategy for production of porous titanium scaffolds for skeletal implants which provides a promising new approach to repair and remodel damaged bone tissue. The new strategy involves powder sintering of titanium powder, employing pharmaceutical sugar pellets as temporary space holders, to facilitate production of porous scaffolds with structures optimized for mechanical performance and osseointegration of implants. The spherical sugar pellets, with controlled size fractions and excellent biocompatibility, are easily removed by dissolution prior to sintering providing an ideal space holder material for controlled synthesis of titanium scaffolds with desired porosities and pore sizes...
February 5, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29404044/formulation-stability-testing-and-analytical-characterization-of-melatonin-based-preparation-for-clinical-trial
#20
Samira Filali, Charlotte Bergamelli, Mamadou Lamine Tall, Damien Salmon, Diane Laleye, Carole Dhelens, Elhadji Diouf, Christine Pivot, Fabrice Pirot
A new institutional clinical trial assessed the improvement of sleep disorders in 40 children with autism treated by immediate-release melatonin formulation in different regimens (0.5 mg, 2 mg, and 6 mg daily) for one month. The objectives of present study were to (i) prepare low-dose melatonin hard capsules for pediatric use controlled by two complementary methods and (ii) carry out a stability study in order to determine a use-by-date. Validation of preparation process was claimed as ascertained by mass uniformity of hard capsules...
August 2017: Journal of Pharmaceutical Analysis
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