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https://www.readbyqxmd.com/read/28626445/adverse-childhood-experiences-are-linked-to-age-of-onset-and-reading-recognition-in-multiple-sclerosis
#1
Michael T Shaw, Natalie O Pawlak, Ariana Frontario, Kathleen Sherman, Lauren B Krupp, Leigh E Charvet
BACKGROUND: Adverse childhood experiences (ACEs) exert a psychological and physiological toll that increases risk of chronic conditions, poorer social functioning, and cognitive impairment in adulthood. OBJECTIVE: To investigate the relationship between childhood adversity and clinical disease features in multiple sclerosis (MS). METHODS: Sixty-seven participants with MS completed the ACE assessment and neuropsychological assessments as part of a larger clinical trial of cognitive remediation...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28623462/in-silico-investigations-of-chemical-constituents-of-clerodendrum-colebrookianum-in-the-anti-hypertensive-drug-targets-rock-ace-and-pde5
#2
Hemant Arya, Safiulla Basha Syed, Sorokhaibam Sureshkumar Singh, Dinakar R Ampasala, Mohane Selvaraj Coumar
Understanding the molecular mode of action of natural product is a key step for developing drugs from them. In this regard, this study is aimed to understand the molecular-level interactions of chemical constituents of Clerodendrum colebrookianum Walp., with anti-hypertensive drug targets using computational approaches. The plant has ethno-medicinal importance for the treatment of hypertension and reported to show activity against anti-hypertensive drug targets-Rho-associated coiled-coil protein kinase (ROCK), angiotensin-converting enzyme, and phosphodiesterase 5 (PDE5)...
June 16, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28605058/cardiovascular-pharmacogenomics-and-cognitive-function-in-patients-with-schizophrenia
#3
Kristen M Ward, A Zarina Kraal, Stephanie A Flowers, Vicki L Ellingrod
STUDY OBJECTIVE: To examine the impact of multiple risk alleles for cognitive dysfunction and cardiovascular disease risk on cognitive function, and to determine if these relationships varied by cognitive reserve (CR) or concomitant medication use in patients with schizophrenia. DESIGN: Cross-sectional study. SETTING: Ambulatory mental health centers. PATIENTS: A total of 122 adults with a schizophrenia spectrum diagnosis who were maintained on a stable antipsychotic regimen for at least 6 months prior to study enrollment; patients were divided into three CR groups based on years of formal education: no high school completion or equivalent (low-education group [18 patients]); completion of high school or equivalent (moderate-education group [36 patients]; or any degree of post-high school education (high-education group [68 patients])...
June 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28593483/adverse-childhood-experiences-in-a-post-bariatric-surgery-psychiatric-inpatient-sample
#4
Kathryn Fink, Colin A Ross
BACKGROUND: Sixty-three inpatients in a psychiatric hospital who had previously undergone bariatric surgery were interviewed by the hospital dietitian. The purpose of the study was to determine the frequency of adverse childhood experiences in this population. METHODS: Participants completed the Adverse Childhood Experiences (ACE) Scale. RESULTS: The average score on the ACE was 5.4 (3.3); 76% of participants reported childhood emotional neglect, 70% childhood verbal abuse, and 64% childhood sexual abuse; only two participants reported no adverse childhood experiences...
June 8, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28592582/adverse-childhood-or-adult-experiences-and-risk-of-bilateral-oophorectomy-a-population-based-case-control-study
#5
Liliana Gazzuola Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, Elizabeth A Stewart, Walter A Rocca
OBJECTIVES: Bilateral oophorectomy has commonly been performed in conjunction with hysterectomy even in women without a clear ovarian indication; however, oophorectomy may have long-term deleterious consequences. To better understand this surgical practice from the woman's perspective, we studied the possible association of adverse childhood or adult experiences with the subsequent occurrence of bilateral oophorectomy. DESIGN: Population-based case-control study...
June 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28559090/the-effect-of-air-removal-with-extracorporeal-balloon-inflation-on-the-incidence-of-asymptomatic-cerebral-embolism-during-cryoballoon-ablation-of-atrial-fibrillation
#6
Michifumi Tokuda, Seiichiro Matsuo, Mika Kato, Hidenori Sato, Hirotsuna Oseto, Eri Okajima, Hidetsugu Ikewaki, Ryota Isogai, Kenichi Tokutake, Kenichi Yokoyama, Ryohsuke Narui, Shin-Ichi Tanigawa, Seigo Yamashita, Keiichi Inada, Michihiro Yoshimura, Teiichi Yamane
BACKGROUND: An asymptomatic cerebral embolism (ACE) is sometimes detected after cryoballoon ablation of atrial fibrillation (AF). The removal of air bubbles from the cryoballoon prior to utilization may reduce the rate of ACE. OBJECTIVE: This study aims to compare the incidence of ACE between a conventional and novel balloon massaging method during cryoballoon ablation. METHODS: Of 175 consecutive patients undergoing initial cryoballoon ablation for paroxysmal AF, 60 patients underwent a novel balloon massaging with extracorporeal balloon inflation in saline water (Group N) before the cryoballoon was inserted into the body...
May 27, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28555706/can-we-predict-morbidity-and-mortality-of-patients-aged-75-years-and-older-undergoing-cystectomy
#7
F Atallah, P Letocart, B Malavaud, M Ahmad, M Mazerolles, V Minville
Radical cystectomy is associated with a high postoperative mortality and morbidity in older patients. We aimed to define the predictive value of comorbidity scores and determine the prognostic factors of postoperative complications. Preoperative associated morbidities were collected and graded according to the American Society of Anesthesiologists (ASA) score system, the Adult Comorbidity Evaluation (ACE) scale and the Charlson comorbidity index. Surgical complications were graded according to Clavien classification...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28552095/abdominal-aortic-aneurysms-pharmacoepidemiological-studies
#8
Holger Wemmelund
An abdominal aortic aneurysm (AAA) is an enlargement of the abdominal aorta. It is a common disease in the elderly, with a prevalence of 1-5%. An AAA is normally asymptomatic, and the diagnosis is often incidental, identified when a patient is examined for other conditions. The major risk of having an AAA is sudden rupture and death caused by massive hemorrhaging. As rupture risk increases with increasing AAA diameter, the current management strategies include regular imaging surveillance and elective repair before rupture occurs...
May 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28511735/addenbrooke-s-cognitive-examination-revised-normative-and-accuracy-data-for-seniors-with-heterogeneous-educational-level-in-brazil
#9
Karolina G César, Mônica S Yassuda, Fabio H G Porto, Sonia M D Brucki, Ricardo Nitrini
BACKGROUND: Several cognitive tools have been developed aiming to diagnose dementia. The cognitive battery Addenbrooke's Cognitive Examination - Revised (ACE-R) has been used to detect cognitive impairment; however, there are few studies including samples with low education. The aim of the study was to provide ACE-R norms for seniors within a lower education, including illiterates. An additional aim was to examine the accuracy of the ACE-R to detect dementia and cognitive impairment no dementia (CIND)...
May 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28498730/exploring-the-association-of-maternal-adverse-childhood-experiences-with-maternal-health-and-child-behavior-following-intimate-partner-violence
#10
Nina Fredland, Judith McFarlane, Lene Symes, John Maddoux
BACKGROUND: Adverse childhood experiences (ACEs) have been empirically linked to a host of negative health outcomes, both physical and psychosocial. Exposures to ACEs make individuals more susceptible to conditions such as cardiovascular disease, diabetes, cancers, and depression. Many of these conditions do not appear until sometime in adolescence or adulthood and have been linked to premature death. OBJECTIVE: This study explores the association between the number and type of exposure to ACEs in women (mothers) who experienced intimate partner violence and health outcomes...
May 12, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28493196/head-and-neck-reconstruction-in-the-elderly-patient-a-safe-procedure
#11
Maximilian Reiter, Philipp Baumeister, Christian Jacobi
Demographic changes strongly affect industrialized countries. While free tissue transfer was initially believed to be beneficial only for younger patients, there is an increasing number of elderly patients requiring microvascular operations in our aging society. Medical and surgical risks for head and neck cancer patients over a certain age who undergo free tissue transfer has hardly been investigated. A retrospective mono-center cohort study was performed. All patients with the age 75 or higher undergoing microvascular operations were reviewed...
May 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28488289/adversity-and-resilience-amongst-resettling-western-australian-paediatric-refugees
#12
Gemma Hanes, Lydia Sung, Raewyn Mutch, Sarah Cherian
AIM: Cumulative adverse childhood experiences have long-term consequences and may manifest within and influence health, educational and psychosocial domains. The Princess Margaret Hospital Refugee Health Service (RHS) undertakes multidisciplinary screening of refugee children <16 years, allowing standardised identification of negative childhood experiences. Addition of the extended Strengths and Difficulties Questionnaire (SDQ) in 2014 aimed to augment psychological assessment of this cohort...
May 10, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28444615/polygenic-study-of-endurance-associated-genetic-markers-ace-i-d-actn3-arg-r-577ter-x-ckmm-a-g-ncoi-and-enos-glu-g-298asp-t-in-male-gorkha-soldiers
#13
Seema Malhotra, Kiran Preet, Arvind Tomar, Shweta Rawat, Sayar Singh, Inderjeet Singh, L Robert Varte, Tirthankar Chatterjee, M S Pal, Soma Sarkar
BACKGROUND: Gorkhas, a sub-mountainous population of the Himalayan region, are known for strength and bravery. In the present study when "Gorkha" is used without brackets, we are mentioning Gorkhas of Tibeto-Burman origin. Physical capability, strength and endurance are important components of fitness associated with genetic traits. The aim of this study was to examine the endurance potential of male Gorkha soldiers, based on endurance-related genetic markers ACE I/D, ACTN3 Arg (R)577Ter(X), CKMM A/G NcoI and eNOS Glu(G)298Asp(T)...
December 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28441432/dysbiosis-of-intestinal-microbiota-and-decrease-in-paneth-cell-antimicrobial-peptide-level-during-acute-necrotizing-pancreatitis-in-rats
#14
Jing Chen, Chunlan Huang, Jingjing Wang, Hui Zhou, Yingying Lu, Lihong Lou, Junyuan Zheng, Ling Tian, Xingpeng Wang, Zhongwei Cao, Yue Zeng
OBJECTIVES: Intestinal barrier dysfunction plays an important role in acute necrotizing pancreatitis (ANP) and intestinal microbiota dysbiosis was involved in intestinal barrier failure. Paneth cells protect intestinal barrier and are associated with intestinal microbiota. Here, we investigated changes in intestinal microbiota and antimicrobial peptides of Paneth cells in ileum during ANP. METHODS: Rats with ANP were established by retrograde injection of 3.5% sodium taurocholate into biliopancreatic duct and sacrificed at 24h and 48h, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28438879/definitive-intensity-modulated-radiation-therapy-in-elderly-patients-with-locally-advanced-oropharyngeal-cancer
#15
Francesca DE Felice, Alessandro Galdieri, Gessica Abate, Nadia Bulzonetti, Daniela Musio, Vincenzo Tombolini
BACKGROUND: To evaluate the treatment tolerance and clinical outcomes in patients aged 70 years and older with locally advanced oropharyngeal cancer treated by definitive intensity-modulated radiation therapy (IMRT). PATIENTS AND METHODS: We retrospectively analyzed 15 consecutive elderly patients, with histologically-proven squamous cell carcinoma of the oropharynx, staged T3-4 with or without involved lymph nodes at diagnosis, who received definitive sequential IMRT (70 Gy; 2 Gy/fraction)...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#16
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28436744/cognitive-screening-in-substance-users-diagnostic-accuracies-of-the-mini-mental-state-examination-addenbrooke-s-cognitive-examination-revised-and-montreal-cognitive-assessment
#17
Nicole Ridley, Jennifer Batchelor, Brian Draper, Apo Demirkol, Nicholas Lintzeris, Adrienne Withall
INTRODUCTION: Despite the considerable prevalence of cognitive impairment in substance-using populations, there has been little investigation of the utility of cognitive screening measures within this context. In the present study the accuracy of three cognitive screening measures in this population was examined-the Mini-Mental State Examination (MMSE), the Addenbrooke's Cognitive Examination-Revised (ACE-R), and the Montreal Cognitive Assessment (MoCA). METHOD: A sample of 30 treatment-seeking substance users and 20 healthy individuals living in the community were administered the screening measures and a neuropsychological battery (NPB)...
April 24, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28431967/family-centered-prevention-ameliorates-the-association-between-adverse-childhood-experiences-and-prediabetes-status-in-young-black-adults
#18
Gene H Brody, Tianyi Yu, Edith Chen, Gregory E Miller
Individuals exposed to adverse childhood experiences (ACEs) are vulnerable to various health problems later in life. This study was designed to determine whether participation in an efficacious program to enhance supportive parenting would ameliorate the association between ACEs and prediabetes status at age 25. Rural African American parents and their 11-year-old children (N=390) participated in the Strong African American Families (SAAF) program or a control condition. Each youth at age 25 provided a total ACEs score and a blood sample from which overnight fasting glucose was assayed...
July 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28431606/screening-for-cognitive-and-behavioural-impairment-in-amyotrophic-lateral-sclerosis-frequency-of-abnormality-and-effect-on-survival
#19
Zhouwei Xu, Ashwag Rafea S Alruwaili, Robert David Henderson, Pamela Ann McCombe
OBJECTIVE: To screen for cognitive and behavioural impairment in people with amyotrophic lateral sclerosis (ALS) and controls with neuromuscular disease and to correlate these with clinical features. METHODS: 108 people with ALS and 60 controls with other neuromuscular diseases were recruited and assessed with the Addenbrooke's cognitive examination-III (ACE-III), the frontal assessment battery (FAB), and the executive function component of the Edinburgh cognitive and behavioural ALS screen (ECAS)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28419887/unpacking-the-impact-of-adverse-childhood-experiences-on-adult-mental-health
#20
Melissa T Merrick, Katie A Ports, Derek C Ford, Tracie O Afifi, Elizabeth T Gershoff, Andrew Grogan-Kaylor
Exposure to childhood adversity has an impact on adult mental health, increasing the risk for depression and suicide. Associations between Adverse Childhood Experiences (ACEs) and several adult mental and behavioral health outcomes are well documented in the literature, establishing the need for prevention. The current study analyzes the relationship between an expanded ACE score that includes being spanked as a child and adult mental health outcomes by examining each ACE separately to determine the contribution of each ACE...
April 15, 2017: Child Abuse & Neglect
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