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https://www.readbyqxmd.com/read/29784755/intergenerational-associations-of-parent-adverse-childhood-experiences-and-child-health-outcomes
#1
Félice Lê-Scherban, Xi Wang, Kathryn H Boyle-Steed, Lee M Pachter
BACKGROUND: Adverse childhood experiences (ACEs) robustly predict future morbidity and mortality. Researchers are just beginning to investigate intergenerational effects. We hypothesize there are intergenerational associations between parent ACE exposure and worse child health, health behaviors, and health care access and use. METHODS: We linked data from 2 population-based cross-sectional telephone surveys in Philadelphia, Pennsylvania, that were used to ask parents about their past exposure to ACEs and their child's health, respectively...
May 21, 2018: Pediatrics
https://www.readbyqxmd.com/read/29780318/the-aerobic-and-cognitive-exercise-study-aces-for-community-dwelling-older-adults-with-or-at-risk-for-mild-cognitive-impairment-mci-neuropsychological-neurobiological-and-neuroimaging-outcomes-of-a-randomized-clinical-trial
#2
Cay Anderson-Hanley, Nicole M Barcelos, Earl A Zimmerman, Robert W Gillen, Mina Dunnam, Brian D Cohen, Vadim Yerokhin, Kenneth E Miller, David J Hayes, Paul J Arciero, Molly Maloney, Arthur F Kramer
Prior research has found that cognitive benefits of physical exercise and brain health in older adults may be enhanced when mental exercise is interactive simultaneously, as in exergaming. It is unclear whether the cognitive benefit can be maximized by increasing the degree of mental challenge during exercise. This randomized clinical trial (RCT), the Aerobic and Cognitive Exercise Study (ACES) sought to replicate and extend prior findings of added cognitive benefit from exergaming to those with or at risk for mild cognitive impairment (MCI)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29757787/screening-for-childhood-adversity-among-adult-primary-care-patients
#3
Karen A Kalmakis, Mary B Shafer, Genevieve E Chandler, Elizabeth V Aponte, Susan J Roberts
BACKGROUND AND PURPOSE: Over half of Americans reports a history of adverse childhood experiences (ACEs), which have been associated with many chronic health conditions. Yet primary care providers infrequently screen patients for ACEs and fail to consider the relationship between ACEs and adult health. Therefore, the purposes of this study were to test the effectiveness and feasibility of a screening interview for ACEs and to confirm the prevalence of ACEs among individuals with chronic health conditions...
April 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29752040/mesenchymal-stem-cell-derived-microvesicles-alleviate-pulmonary-arterial-hypertension-by-regulating-renin-angiotensin-system
#4
Zhenjun Liu, Jinghu Liu, Mengyuan Xiao, Junxian Wang, Feng Yao, Weikai Zeng, Liqin Yu, Yuejie Guan, Wenyan Wei, Zijian Peng, Kunpeng Zhu, Jin Wang, Zhongyuan Yang, Jixin Zhong, Jianying Chen
In recent years, microvesicles (MVs) derived from mesenchymal stem cells (MSCs) have been proved to be able to improve the outcome of pulmonary arterial hypertension (PAH) in many respects, but the underlying mechanisms of it still remain unclear. Because the renin-angiotensin system (RAS) has been found to be closely related to PAH, the present study was designed to investigate whether the effect of MSC-derived MVs on PAH was correlated with RAS. MVs were isolated and purified from bone marrow MSCs. PAH rat models were established by a single intraperitoneal injection of 1% monocrotaline (MCT, 50 mg/Kg)...
March 15, 2018: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29745688/emotion-regulation-mediates-the-relationship-between-aces-and-physical-and-mental-health
#5
Marylene Cloitre, Christina Khan, Margaret-Anne Mackintosh, Donn W Garvert, Clare M Henn-Haase, Erin C Falvey, Jean Saito
OBJECTIVE: Adverse Childhood Experiences (ACEs) have consistently been associated with a range of negative psychological and physical outcomes in adulthood. Despite the strength of this association, no studies to date have investigated psychological processes that might underlie this relationship. The current study evaluated emotion regulation as a potential mediator between ACEs and three outcomes: PTSD symptoms, depression and poor physical health, all of which are frequently co-occurring among women with ACEs...
May 10, 2018: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/29739796/prevalence-of-carotid-plaque-in-a-63-to-65-year-old-norwegian-cohort-from-the-general-population-the-ace-akershus-cardiac-examination-1950-study
#6
Håkon Ihle-Hansen, Thea Vigen, Hege Ihle-Hansen, Ole Morten Rønning, Trygve Berge, Bente Thommessen, Magnus Nakrem Lyngbakken, Eivind Bjørkan Orstad, Steve Enger, Ståle Nygård, Helge Røsjø, Arnljot Tveit
BACKGROUND: New data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular risk control in the population may have changed patterns of carotid arterial wall disease and actual prevalence of established cardiovascular disease. We investigated the prevalence of atherosclerotic carotid plaques and carotid intima-media thickness (cIMT) and their relation to cardiovascular risk factors in a middle-aged cohort from the general population...
May 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29708964/antibiotic-combination-efficacy-ace-networks-for-a-pseudomonas-aeruginosa-model
#7
Camilo Barbosa, Robert Beardmore, Hinrich Schulenburg, Gunther Jansen
The spread of antibiotic resistance is always a consequence of evolutionary processes. The consideration of evolution is thus key to the development of sustainable therapy. Two main factors were recently proposed to enhance long-term effectiveness of drug combinations: evolved collateral sensitivities between the drugs in a pair and antagonistic drug interactions. We systematically assessed these factors by performing over 1,600 evolution experiments with the opportunistic nosocomial pathogen Pseudomonas aeruginosa in single- and multidrug environments...
April 30, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29708489/fmri-as-a-preimplant-objective-tool-to-predict-children-s-postimplant-auditory-and-language-outcomes-as-measured-by-parental-observations
#8
Aniruddha K Deshpande, Lirong Tan, Long J Lu, Mekibib Altaye, Scott K Holland
BACKGROUND: The trends in cochlear implantation candidacy and benefit have changed rapidly in the last two decades. It is now widely accepted that early implantation leads to better postimplant outcomes. Although some generalizations can be made about postimplant auditory and language performance, neural mechanisms need to be studied to predict individual prognosis. PURPOSE: The aim of this study was to use functional magnetic resonance imaging (fMRI) to identify preimplant neuroimaging biomarkers that predict children's postimplant auditory and language outcomes as measured by parental observation/reports...
May 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29708208/apathy-and-functional-disability-in-behavioral-variant-frontotemporal-dementia
#9
Mônica S Yassuda, Thais B Lima da Silva, Claire M O'Connor, Shailaja Mekala, Suvarna Alladi, Valeria S Bahia, Viviane Almaral-Carvalho, Henrique C Guimaraes, Paulo Caramelli, Marcio L F Balthazar, Benito Damasceno, Sonia M D Brucki, Ricardo Nitrini, John R Hodges, Olivier Piguet, Eneida Mioshi
Background: Behavioral variant frontotemporal dementia (bvFTD) has profound consequences on patients and their families. In this multicenter study, we investigated the contribution of cognitive and neuropsychiatric factors to everyday function at different levels of overall functional impairment. Methods: In a retrospective cross-sectional study, 109 patients with bvFTD from 4 specialist frontotemporal dementia centers (Australia, England, India, and Brazil) were included...
April 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29701834/adjustment-of-the-grace-score-by-2-hour-post-load-glucose-improves-prediction-of-long-term-major-adverse-cardiac-events-in-acute-coronary-syndrome-in-patients-without-known-diabetes
#10
Sudipta Chattopadhyay, Anish George, Joseph John, Thozhukat Sathyapalan
Aims: Global Registry of Acute Coronary Events (GRACE) risk score (GRS), a powerful predictor of prognosis after acute coronary event (ACE), does not include a glucometabolic measure. We investigate whether 2 h post-load plasma glucose (2h-PG) could improve GRS based prognostic models in ACE patients without known diabetes mellitus (DM). Methods and results: A retrospective cohort study of 1056 ACE survivors without known DM who had fasting plasma glucose (FPG) and 2h-PG measured pre-discharge...
April 26, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29679816/poor-mental-health-among-low-income-women-in-the-u-s-the-roles-of-adverse-childhood-and-adult-experiences
#11
Joshua P Mersky, Colleen E Janczewski, Jenna C Nitkowski
RATIONALE: It is well established that exposure to a greater number of adverse childhood experiences (ACEs) increases the risk of poor physical and mental health outcomes. Given the predictive validity of ACE scores and other cumulative risk metrics, a similar measurement approach may advance the study of risk in adulthood. OBJECTIVE: We examined the prevalence and interrelations of 10 adverse adult experiences, including household events such as intimate partner violence and extrafamilial events such as crime victimization...
April 14, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29679193/etiology-of-stability-and-growth-of-internalizing-and-externalizing-behavior-problems-across-childhood-and-adolescence
#12
Alexander S Hatoum, Soo Hyun Rhee, Robin P Corley, John K Hewitt, Naomi P Friedman
Internalizing and externalizing behaviors are heritable, and show genetic stability during childhood and adolescence. Less work has explored how genes influence individual differences in developmental trajectories. We estimated ACE biometrical latent growth curve models for the Teacher Report Form (TRF) and parent Child Behavior Checklist (CBCL) internalizing and externalizing scales from ages 7 to 16 years in 408 twin pairs from the Colorado Longitudinal Twin Study. We found that Intercept factors were highly heritable for both internalizing and externalizing behaviors (a2 = ...
April 20, 2018: Behavior Genetics
https://www.readbyqxmd.com/read/29673592/intravenous-vitamin-c-attenuates-hemorrhagic-shock-related-renal-injury-through-the-induction-of-sirt1-in-rats
#13
Meng-Zhi Qi, Yi Yao, Rong-Li Xie, Si-Lei Sun, Wen-Wu Sun, Jin-Long Wang, Ying Chen, Bing Zhao, Er-Zhen Chen, En-Qiang Mao
To investigate the effect of intravenous Vitamin C (VC) on hemorrhagic shock (HS)-associated rat renal injury and the involved mechanism. Thirty SD rats were randomly assigned to the sham surgery (sham), hemorrhagic shock (HS), HS+100 mg/kg VC (H + VL), HS+500 mg/kg VC (H + VH) and HS+100 mg/kg VC + EX527 (H + VL + E) groups. Tissue and blood samples were collected 6 h after surgery. Kidney pathological changes were scored. Creatinine (CRE), blood urea nitrogen (BUN), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) levels in serum and Vitamin C levels and superoxide dismutase (SOD) activity and the ability to suppress hydroxyl radical (RAFHR) in plasma were measured...
April 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29668736/differing-patterns-of-stress-and-craving-across-the-day-in-moderate-heavy-alcohol-consumers-during-their-typical-drinking-routine-and-an-imposed-period-of-alcohol-abstinence
#14
Rhiannon E Mayhugh, W Jack Rejeski, Meredith R Petrie, Paul J Laurienti, Lise Gauvin
BACKGROUND: Stress is a known factor related to alcohol use. However, how the relationship between alcohol craving and stress varies across the day is not fully understood. As craving is a consistent predictor of alcohol use disorder (AUD), understanding stress and craving patterns across the day in routine, non-dependent, moderate-heavy alcohol consumers may help in understanding those who may be vulnerable to transitioning into AUD. METHOD: Moderate-heavy drinkers were recruited from the local community (n = 32) and assessed for fluctuations in craving and stress intensity across the day via Ecological Momentary Assessment (EMA) during 3 consecutive days of imposed alcohol abstinence (abstained trial) and their normal drinking routine (normal trial)...
2018: PloS One
https://www.readbyqxmd.com/read/29617523/effects-of-sacubitril-valsartan-on-physical-and-social-activity-limitations-in-patients-with-heart-failure-a-secondary-analysis-of-the-paradigm-hf-trial
#15
Alvin Chandra, Eldrin F Lewis, Brian L Claggett, Akshay S Desai, Milton Packer, Michael R Zile, Karl Swedberg, Jean L Rouleau, Victor C Shi, Martin P Lefkowitz, Tzvetana Katova, John J V McMurray, Scott D Solomon
Importance: Health-related quality of life (HRQL) of patients with heart failure is markedly reduced compared with that in patients with other chronic diseases, demonstrating substantial limitations in physical and social activities. In the Prospective Comparison of ARNI With an ACE-Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial, sacubitril/valsartan improved overall HRQL compared with enalapril, as determined by the Kansas City Cardiomyopathy Questionnaire (KCCQ)...
April 4, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29584563/adverse-childhood-experiences-among-direct-support-professionals
#16
John M Keesler
Direct support professionals (DSPs) provide integral support to many individuals with intellectual and developmental disabilities (IDD). Yet, individuals' access to qualified DSPs is often compromised as organizations struggle to hire and retain DSPs. Despite a vast body of research exploring factors associated with turnover, adverse childhood experiences (ACEs) among DSPs remain absent from the literature. ACEs encompass abuse and familial dysfunction prior to the age of 18 and, in the general population, have been linked to compromised well-being and work-related challenges in adult life...
April 2018: Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29582957/-renal-manifestation-of-autosomal-dominant-polycystic-kidney-disease
#17
Marco Galliani, Silvana Chicca, Elio Vitaliano, Luca Di Lullo, Konstantinos Giannakakis, Antonio Paone
Autosomal dominant polycystic kidney disease affects over 12 million people in the world and is the fourth cause of ESRD. It is the main monogenic kidney disease and causes the progressive formation of cysts leading to renal failure after a few decades. The main manifestations of the disease are observed even at a young age. The early sign of ADPKD is impaired urinary concentrating capacity, due to medullary alteration by cysts, and resistance to vasopressin. These anatomical alterations determine hyperfiltration, altered ammonium transport, nephrolithiasis, and, above all, hypertension even in pediatric age...
March 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29574684/associations-between-polypharmacy-and-cognitive-and-physical-capability-a-british-birth-cohort-study
#18
Mark James Rawle, Rachel Cooper, Diana Kuh, Marcus Richards
OBJECTIVES: To investigate longitudinal associations between polypharmacy and cognitive and physical capability and to determine whether these associations differ with cumulative exposure to polypharmacy. DESIGN: Prospective birth cohort study. SETTING: England, Scotland, and Wales. PARTICIPANTS: An eligible sample of men and women from the Medical Research Council National Survey of Health and Development with medication data at age 69 (N=2,122, 79%)...
March 24, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29573192/responses-of-fungal-community-composition-to-long-term-chemical-and-organic-fertilization-strategies-in-chinese-mollisols
#19
Mingchao Ma, Xin Jiang, Qingfeng Wang, Marc Ongena, Dan Wei, Jianli Ding, Dawei Guan, Fengming Cao, Baisuo Zhao, Jun Li
How fungi respond to long-term fertilization in Chinese Mollisols as sensitive indicators of soil fertility has received limited attention. To broaden our knowledge, we used high-throughput pyrosequencing and quantitative PCR to explore the response of soil fungal community to long-term chemical and organic fertilization strategies. Soils were collected in a 35-year field experiment with four treatments: no fertilizer, chemical phosphorus, and potassium fertilizer (PK), chemical phosphorus, potassium, and nitrogen fertilizer (NPK), and chemical phosphorus and potassium fertilizer plus manure (MPK)...
March 23, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29563237/parental-adverse-childhood-experiences-and-resilience-on-coping-after-discharge
#20
Anita N Shah, Andrew F Beck, Heidi J Sucharew, Stacey Litman, Cory Pfefferman, Julianne Haney, Samir S Shah, Jeffrey M Simmons, Katherine A Auger
BACKGROUND AND OBJECTIVES: Adults with a history of adverse childhood experiences (ACEs) (eg, abuse) have suboptimal health outcomes. Resilience may blunt this effect. The effect of parental ACEs (and resilience) on coping with challenges involving their children (eg, hospitalization) is unclear. We sought to quantify ACE and resilience scores for parents of hospitalized children and evaluate their associations to parental coping after discharge. METHODS: We conducted a prospective cohort study at a children's hospital (August 2015-May 2016)...
April 2018: Pediatrics
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