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https://www.readbyqxmd.com/read/27912977/functional-outcomes-in-hirschsprung-disease-a-single-institution-s-12-year-experience
#1
Hemanshoo S Thakkar, Christopher Bassett, Andy Hsu, Riccardo Manuele, Dorothy Kufeji, Catherine A Richards, Meena Agrawal, Alireza S Keshtgar
AIMS: Hirschsprung disease (HD) is a chronic condition associated with long-term morbidity. We assessed the short and long-term functional outcomes of operated patients in a single institution over a 12-year period. MATERIALS AND METHODS: We conducted a retrospective review of all children operated for HD between 2002 and 2014. Postoperative functional outcomes were assessed using the Rintala Bowel Function Score (BFS, 0-20, 20=best score). We assessed hospital admissions, complications including Hirschsprung associated enterocolitis (HAEC) and the need for further surgical procedures...
November 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27899519/initial-clinical-experience-using-the-two-stage-aspiration-technique-tsat-with-proximal-flow-arrest-by-a-balloon-guiding-catheter-for-acute-ischemic-stroke-of-the-anterior-circulation
#2
Hiroyuki Matsumoto, Hirokazu Nishiyama, Yoshiaki Tetsuo, Hideki Takemoto, Naoyuki Nakao
BACKGROUND: Our initial experience using the two-stage aspiration technique (TSAT) with proximal flow arrest by a balloon guiding catheter is presented. In TSAT, aspiration is applied with the 5MAX ACE and also with the 3MAX catheter with a Penumbra aspiration pump, while arresting proximal flow by balloon inflation. METHODS: In patients treated with TSAT, clinical data including National Institutes of Health Stroke Scale (NIHSS) score at admission and the modified Rankin Scale (mRS) score at discharge, as well as procedural data including the Thrombolysis in Cerebral Infarction (TICI) score, procedural time, and complications were analyzed...
November 29, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27887683/sacral-nerve-stimulation-allows-for-decreased-antegrade-continence-enema-use-in-children-with-severe-constipation
#3
Peter L Lu, Lindsey Asti, Daniel L Lodwick, Kristine M Nacion, Katherine J Deans, Peter C Minneci, Steven Teich, Seth A Alpert, Desale Yacob, Carlo Di Lorenzo, Hayat M Mousa
BACKGROUND: Sacral nerve stimulation (SNS) can be beneficial for children with constipation, but no studies have focused on children with constipation severe enough to require antegrade continence enemas (ACEs). Our objective was to evaluate the efficacy of SNS in children with constipation treated with ACE. METHODS: Using a prospective patient registry, we identified patients <21years old who were receiving ACE prior to SNS placement. We compared ACE/laxative usage, PedsQL Gastrointestinal Symptom Scale (GSS), Fecal Incontinence Quality of Life Scale (FIQL), Fecal Incontinence Severity Index (FISI), and Vancouver Dysfunctional Elimination Syndrome Score (DES) at baseline and progressive follow-up time intervals...
November 10, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27884212/angiotensin-converting-enzyme-2-is-reduced-in-alzheimer-s-disease-in-association-with-increasing-amyloid-%C3%AE-and-tau-pathology
#4
Patrick Gavin Kehoe, Steffenny Wong, Noura Al Mulhim, Laura Elyse Palmer, J Scott Miners
BACKGROUND: Hyperactivity of the classical axis of the renin-angiotensin system (RAS), mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is implicated in the pathogenesis of Alzheimer's disease (AD). Angiotensin-converting enzyme-2 (ACE-2) degrades Ang II to angiotensin 1-7 (Ang (1-7)) and counter-regulates the classical axis of RAS. We have investigated the expression and distribution of ACE-2 in post-mortem human brain tissue in relation to AD pathology and classical RAS axis activity...
November 25, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27875168/colorgorical-creating-discriminable-and-preferable-color-palettes-for-information-visualization
#5
Connor C Gramazio, David H Laidlaw, Karen B Schloss
We present an evaluation of Colorgorical, a web-based tool for creating discriminable and aesthetically preferable categorical color palettes. Colorgorical uses iterative semi-random sampling to pick colors from CIELAB space based on user-defined discriminability and preference importances. Colors are selected by assigning each a weighted sum score that applies the user-defined importances to Perceptual Distance, Name Difference, Name Uniqueness, and Pair Preference scoring functions, which compare a potential sample to already-picked palette colors...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27862810/angiotensin-converting-enzyme-insertion-deletion-polymorphism-and-the-longitudinal-progression-of-alzheimer-s-disease
#6
Ping-Song Chou, Meng-Ni Wu, Mei-Chuan Chou, I Chien, Yuan-Han Yang
AIM: The angiotensin-converting enzyme gene (ACE) insertion (I)/deletion (D) polymorphism is considered a biologically plausible gene for Alzheimer's disease (AD) in cross-sectional studies. The present study aimed to investigate the longitudinal effect of ACE I/D polymorphism on AD progression. METHODS: This 3-year observational study investigated the longitudinal effect of ACE I/D polymorphism on AD progression. Clinically diagnosed AD patients with a clinical dementia rating (CDR) of 0...
November 10, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27854209/aceneuramic-acid-extended-release-administration-maintains-upper-limb-muscle-strength-in-a-48-week-study-of-subjects-with-gne-myopathy-results-from-a-phase-2-randomized-controlled-study
#7
Zohar Argov, Yoseph Caraco, Heather Lau, Alan Pestronk, Perry B Shieh, Alison Skrinar, Tony Koutsoukos, Ruhi Ahmed, Julia Martinisi, Emil Kakkis
BACKGROUND: GNE Myopathy (GNEM) is a progressive adult-onset myopathy likely caused by deficiency of sialic acid (SA) biosynthesis. OBJECTIVE: Evaluate the safety and efficacy of SA (delivered by aceneuramic acid extended-release [Ace-ER]) as treatment for GNEM. METHODS: A Phase 2, randomized, double-blind, placebo-controlled study evaluating Ace-ER 3 g/day or 6 g/day versus placebo was conducted in GNEM subjects (n = 47). After the first 24 weeks, placebo subjects crossed over to 3 g/day or 6 g/day for 24 additional weeks (dose pre-assigned during initial randomization)...
March 3, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27828612/adverse-childhood-experiences-and-consumption-of-alcohol-tobacco-and-illicit-drugs-among-adolescents-of-a-brazilian-birth-cohort
#8
Helen Gonçalves, Ana Luiza Gonçalves Soares, Ana Paula Gomes Dos Santos, Camila Garcez Ribeiro, Isabel Oliveira Bierhals, Luna Strieder Vieira, Natália Limões Hellwig, Fernando C Wehrmeister, Ana M B Menezes
The objective of this study was to investigate the association between adverse childhood experiences (ACEs) and the use of alcohol, tobacco and illicit drugs among adolescents from a Brazilian cohort. The occurrence of five ACEs, the use of alcohol and tobacco and trying illicit drugs were investigated in the 1993 Pelotas birth cohort at the age of 15 (n = 4,230). A score was created for the ACEs and their association with the use of substances was evaluated. Around 25% of adolescents consumed alcohol, 6% smoked and 2...
November 3, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27806896/racial-ethnic-differences-in-the-association-of-childhood-adversities-with-depression-and-the-role-of-resilience
#9
Nagy A Youssef, Daniel Belew, Guang Hao, Xiaoling Wang, Frank A Treiber, Michael Stefanek, Mark Yassa, Elizabeth Boswell, W Vaughn McCall, Shaoyong Su
BACKGROUND: Adverse childhood experiences (ACE) including childhood abuse and trauma increase depressive symptoms. The role of resilience and how it interacts with both ACEs and the potential development of depressive symptoms, including how race and ethnicity moderate these effects, are much less studied. The aims of this study were to examine: 1) whether there is a dose-response relationship between trauma and depressive symptoms; 2) whether early trauma affected European Americans (EA) and African Americans (AA) in a similar fashion; and 3) whether resilience mitigates the effect of trauma...
October 24, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27791272/evaluation-of-the-predictors-of-readmission-in-korean-patients-with-heart-failure
#10
J E Chung, E Noh, H S Gwak
WHAT IS KNOWN AND OBJECTIVE: Various factors contribute to the high rate of readmission among patients hospitalized with heart failure (HF). Determination of these factors is fundamental to identify potential targets for intervention in hospitalized patients. METHODS: The retrospective cohort study used a large national insurance database to identify episodes of HF. Clinical information up to 12 months from the index hospitalization was obtained. Depending on their outcome, eligible patients were classified into a 30-day readmission group after discharge or a non-readmission group...
October 28, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27757137/the-thai-version-of-the-addenbrooke-s-cognitive-examination-iii
#11
Thammanard Charernboon, Kankamol Jaisin, Tiraya Lerthattasilp
The objective of our study was to assess the accuracy of the Thai version of the Addenbrooke's Cognitive Examination III (ACE-T). We used the ACE-T to assess 107 participants aged 60 or over, divided into the following groups: early dementia, n=30; mild cognitive impairment (MCI), n=29; and normal controls (NC), n=48. The ACE-T exhibited good internal consistency (0.93) and inter-rater reliability (1.0). The optimal cut-off score for the ACE-T to differentiate MCI from NC was 75/76, giving a sensitivity of 0...
September 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27755987/interictal-epileptiform-discharges-were-associated-with-poorer-cognitive-performance-in-adult-epileptic-patients
#12
Xiao-Ying Liu, Tao Shi, Wei-Na Yin, Zhen-Yu Ren, Yu-Lei Deng, Sheng-Di Chen
OBJECTIVE: Cognitive impairment is one of the major consequences of epilepsy and has been shown to reduce quality of life. Interictal epileptiform discharges (IEDs) were associated with poorer cognitive performance in children, and the aim of this study was to determine whether there was a similar association in adults. METHODS: A prospective cohort of 167 seizure-free adult patients underwent EEG recording and extensive cognitive evaluations. Global cognition was evaluated using Addenbrooke's Cognitive Examination-Revised (ACE-R), while sub-dimensions of cognition were evaluated using the Auditory Verbal Learning Test (AVLT), Trial Making Test (TMT)-A and -B, and the 5 constitutive subscales of ACE-R...
September 30, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27753868/poa-02-1-genetic-basis-of-blood-pressure-and-hypertension
#13
Anna F Dominiczak
Human primary or essential hypertension is a complex, polygenic trait with some 50% contribution from genes and environment. Richard Lifton and colleagues provided elegant dissection of several rare Mendelian forms of hypertension, exemplified by the glucocorticoid remediable aldosteronism and Liddle's syndrome. These discoveries illustrate that a single gene mutation can explain the entire pathogenesis of severe, early onset hypertension as well as dictating the best treatment. The dissection of the much more common polygenic hypertension has proven much more difficult...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753828/sy-03-1-genetic-basis-of-blood-pressure-and-hypertension
#14
Anna Dominiczak
Human primary or essential hypertension is a complex, polygenic trait with some 50% contribution from genes and environment. Richard Lifton and colleagues provided elegant dissection of several rare Mendelian forms of hypertension, exemplified by the glucocorticoid remediable aldosteronism and Liddle's syndrome. These discoveries illustrate that a single gene mutation can explain the entire pathogenesis of severe, early onset hypertension as well as dictating the best treatment.The dissection of the much more common polygenic hypertension has proven much more difficult...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753563/exploring-the-prevalence-of-adverse-childhood-experiences-in-soldiers-seeking-behavioral-health-care-during-a-combat-deployment
#15
Larry Applewhite, Derrick Arincorayan, Barry Adams
This exploratory study examines the prevalence of adverse childhood experiences (ACEs) in soldiers who sought behavioral health support during a combat deployment. We conducted a secondary analysis of data extracted from two studies on the basis of retrospective reviews of behavioral health records of soldiers deployed to Iraq or Afghanistan. Of 162 clinical samples, 135 (83%) reported at least one type of childhood adversity. ACE scores ranged from 0 to 9 with a mean of 3 (standard deviation = 2.4) and mode of 0...
October 2016: Military Medicine
https://www.readbyqxmd.com/read/27742425/relation-among-clot-burden-right-sided-heart-strain-and-adverse-events-after-acute-pulmonary-embolism
#16
Praveen Hariharan, David M Dudzinski, Rachel Rosovsky, Farris Haddad, Peter MacMahon, Blair Parry, Yuchiao Chang, Christopher Kabrhel
Computed tomography pulmonary angiogram (CTPA) provides a volumetric assessment of clot burden in acute pulmonary embolism (PE). However, it is unclear if clot burden is associated with right-sided heart strain (RHS) or adverse clinical events (ACE). We prospectively enrolled Emergency Department patients with PE (in CTPA) from 2008 to 2011. We assigned 1 to 9 points as clot burden score, based on whether emboli were saddle, central, lobar, segmental, and subsegmental. We evaluated a novel score (the "CT-PASS") based on the sum (in millimeters) of the largest filling defects in the right and left pulmonary vasculature...
August 24, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27732646/value-of-different-comorbidity-indices-for-predicting-outcome-in-patients-with-acute-myeloid-leukemia
#17
Maxi Wass, Friederike Hitz, Judith Schaffrath, Carsten Müller-Tidow, Lutz P Müller
Age is a dominant predictor of outcome in acute myeloid leukemia (AML). However, it is not clear to which extent comorbidities contribute to this effect. The objective of this study was to determine the impact of pretreatment comorbidities on survival of AML patients. In a single-center retrospective study 194 adult AML patients were included. The Hematopoietic cell transplantation comorbidity index (HCT-CI), the Adult Comorbidity Evaluation-27 (ACE-27) score and the Cumulative Illness Rating Scale for Geriatrics (CIRS-G) as well as data on demographics, cytogenetics, treatment and outcome were evaluated at the time of initial diagnosis by univariate and multivariate analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27726294/role-of-comorbidity-on-outcome-of-head-and-neck-cancer-a-population-based-study-in-thuringia-germany
#18
Irene Göllnitz, Johanna Inhestern, Thomas G Wendt, Jens Buentzel, Dirk Esser, Daniel Böger, Andreas H Mueller, Jörn-Uwe Piesold, Stefan Schultze-Mosgau, Ekkehard Eigendorff, Peter Schlattmann, Orlando Guntinas-Lichius
To examine the impact of comorbidity on overall survival (OS) in a population-based study of patients with head and neck cancer who were treated between 2009 and 2011. Data of 1094 patients with primary head and neck carcinomas without distant metastasis from the Thuringian cancer registries were evaluated concerning the influence of patient's characteristics and comorbidity on OS. Data on comorbidity prior to head and neck cancer diagnosis was adapted to the Charlson Comorbidity (CCI), age-adjusted CCI (ACCI), head and neck CCI (HNCCI), simplified comorbidity score (SCS), and to the Adult Comorbidity Evaluation-27 (ACE-27)...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27717681/efficiency-of-the-penumbra-5max-ace-reperfusion-catheter-in-acute-ischemic-stroke-patients
#19
Kentaro Suzuki, Junya Aoki, Yuki Sakamoto, Takuya Kanamaru, Arata Abe, Satoshi Suda, Seiji Okubo, Kazumi Kimura
OBJECTIVE: This study was performed to investigate whether the Penumbra 5MAX ACE is superior to other Penumbra systems. MATERIALS AND METHODS: We performed a retrospective, single center analysis of patients with acute ischemic stroke with occlusion of the internal carotid artery or middle cerebral artery (M1 segment) who underwent endovascular therapy using a Penumbra system. The reperfusion success rate, puncture-to-revascularization time, and number of passes were assessed...
October 4, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27710773/bioactive-peptides-in-beef-endogenous-generation-through-postmortem-aging
#20
Yu Fu, Jette F Young, Margrethe Therkildsen
The present research was performed to investigate endogenous release of bioactive peptides in beef during postmortem aging times (1, 10 and 20days). Gradually decreased Warner-Bratzler shear force (WBSF) values of longissimus thoracis (LT) and semitendinosus (ST) muscles were observed and the degradation of structural proteins and collagen led to release of low-molecular weight (<3kDa) peptides. These peptides exhibited 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity, ACE- and renin-inhibitory activities...
September 30, 2016: Meat Science
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