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https://www.readbyqxmd.com/read/29140910/polygenic-profile-and-exercise-induced-muscle-damage-by-a-competitive-half-ironman
#1
Juan Del Coso, Juan J Salinero, Beatriz Lara, César Gallo-Salazar, Francisco Areces, David Herrero, Carlos Puente
Del Coso, J, Salinero, JJ, Lara, B, Gallo-Salazar, C, Areces, F, Herrero, D, and Puente, C. Polygenic profile and exercise-induced muscle damage by a competitive half-ironman. J Strength Cond Res XX(X): 000-000, 2017-To date, it is still unknown why some individuals develop higher levels of muscle damage than other individuals, despite participating in exercise with comparable levels of physical intensity. The aim of this investigation was to analyze 7 single-nucleotide polymorphisms (SNPs) that are candidates to explain individual variations in the level of muscle damage attained during a half-ironman competition...
November 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29140276/clinical-profile-associated-with-adverse-childhood-experiences-the-advent-of-nervous-system-dysregulation
#2
Jorina Elbers, Cynthia R Rovnaghi, Brenda Golianu, Kanwaljeet J S Anand
BACKGROUND: We report the prevalence of children with multiple medical symptoms in a pediatric neurology clinic, describe their symptom profiles, and explore their association with adverse childhood experiences (ACEs). METHODS: We retrospectively reviewed 100 consecutive patients from an outpatient pediatric neurology clinic. Patients were included if they were ≥5 years old and reported ≥4 symptoms that were unexplained for ≥3-months. Symptom profiles across six functional domains were recorded: (1) executive dysfunction, (2) sleep disturbances, (3) autonomic dysregulation, (4) somatization, (5) digestive symptoms, and (6) emotional dysregulation...
November 15, 2017: Children
https://www.readbyqxmd.com/read/29137820/does-acute-care-for-the-elderly-ace-unit-decrease-the-incidence-of-falls
#3
Ahmed Abdalla, Mehul Adhaduk, Raad A Haddad, Yanal Alnimer, Carlos F Ríos-Bedoya, Ghassan Bachuwa
To determine whether acute care for the elderly (ACE) units decrease the incidence of patient falls compared to general medical and surgical (GMS) units, a non-concurrent prospective study included individuals aged 65 and older admitted to ACE or GMS units over a 2-year span was done. There were 7069 admissions corresponded to 28,401 patient-days. A total of 149 falls were reported for an overall incidence rate (IR) of 5.2 falls per 1000 patient-days, 95% CI, 4.4/1000-6.1/1000 patient-days. The falls IR ratio for patients in ACE unit compared to those in non-ACE units after adjusting for age, sex, prescribed psychotropics and hypnotics, and Morse Fall Score was 0...
November 11, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29135081/adverse-childhood-experiences-aces-and-adiposity-in-adolescents-a-cross-cohort-comparison
#4
Ana Luiza G Soares, Alicia Matijasevich, Ana M B Menezes, Maria Cecília Assunção, Fernando C Wehrmeister, Laura D Howe, Helen Gonçalves
OBJECTIVE: This study aimed to assess the association between adverse childhood experiences (ACEs) and adiposity in adolescents from two cohorts in different socioeconomic contexts. METHODS: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC, United Kingdom) and the 1993 Pelotas Cohort (Brazil) were used. Six ACEs were assessed in both cohorts up to age 15. At 15 years, body mass index (BMI) and waist circumference (WC) were measured, and at 18 years, BMI, fat mass index, and android fat percentage were assessed...
November 14, 2017: Obesity
https://www.readbyqxmd.com/read/29095966/systematic-screening-for-atrial-fibrillation-in-a-65-year-old-population-with-risk-factors-for-stroke-data-from-the-akershus-cardiac-examination-1950-study
#5
Trygve Berge, Jon Brynildsen, Hege K Netmangen Larssen, Sophia Onarheim, Gaute R Jenssen, Haakon Ihle-Hansen, Ingrid E Christophersen, Marius Myrstad, Helge Røsjø, Pål Smith, Arnljot Tveit
Aims: To investigate the yield of screening for atrial fibrillation (AF) in a cohort of 65-year-old individuals from the general population with additional risk factors for stroke. Methods and results: We invited participants with additional risk factors for stroke (CHA2DS2-VASc score ≥2 for men or ≥ 3 for women) without previously known AF from a population-based study in Norway to participate in a 2-week screening for AF. Screening was performed by one-lead 'thumb electrocardiography (ECG)' recordings of 30 s twice daily or when the participants experienced symptoms...
October 31, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29090329/predictors-of-change-of-trabecular-bone-score-tbs-in-older-men-results-from-the-osteoporotic-fractures-in-men-mros-study
#6
J T Schousboe, T N Vo, L Langsetmo, B C Taylor, A M Kats, A V Schwartz, D C Bauer, J A Cauley, K E Ensrud
Among older men, characteristics that predict longitudinal changes in trabecular bone score (TBS) are different from characteristics that predict changes in bone mineral density (BMD). Most notably, weight loss is strongly associated with concomitant loss in BMD but with concomitant increases in TBS, when measured on Hologic densitometers. INTRODUCTION: Our objective was to compare and contrast predictors of changes in TBS, total hip BMD, and lumbar spine BMD. METHODS: Our study population was 3969 Osteoporotic Fractures in Men (MrOS) cohort participants (mean age 72...
October 31, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29089148/is-the-coronary-artery-calcium-score-associated-with-acute-coronary-events-in-breast-cancer-patients-treated-with-radiotherapy
#7
Catharina T G Roos, Veerle A B van den Bogaard, Marcel J W Greuter, Rozemarijn Vliegenthart, Ewoud Schuit, Johannes A Langendijk, Arjen van der Schaaf, Anne P G Crijns, John H Maduro
BACKGROUND AND PURPOSE: The main objective of this study was to test whether pre-treatment coronary artery calcium (CAC) was associated with the cumulative incidence of acute coronary events (ACE) among breast cancer (BC) patients treated with postoperative radiotherapy (RT). MATERIAL AND METHODS: The study population consisted of 939 consecutive female BC patients treated with RT. The association between CAC and ACE was tested using Cox-proportional hazard models...
October 28, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29084329/association-between-early-life-adversity-and-risk-for-poor-emotional-and-physical-health-in-adolescence-a-putative-mechanistic-neurodevelopmental-pathway
#8
Joan L Luby, Deanna Barch, Diana Whalen, Rebecca Tillman, Andy Belden
Importance: Adverse childhood experiences (ACEs) have been associated with poor mental and physical health outcomes. However, the mechanism of this effect, critical to enhancing public health, remains poorly understood. Objective: To investigate the neurodevelopmental trajectory of the association between early ACEs and adolescent general and emotional health outcomes. Design, Setting, and Participants: A prospective longitudinal study that began when patients were aged 3 to 6 years who underwent neuroimaging later at ages 7 to 12 years and whose mental and physical health outcomes were observed at ages 9 to 15 years...
October 30, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29034839/pharmacogenetics-of-angiotensin-converting-enzyme-inhibitors-in-patients-with-alzheimer-s-disease-dementia
#9
Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucci
BACKGROUND: While the angiotensin-converting enzyme degrades amyloid-β, angiotensin-converting enzyme inhibitors (ACEis) may slow cognitive decline by way of cholinergic effects, by increasing brain substance P and boosting the activity of neprilysin, and by modulating glucose homeostasis and augmenting the secretion of adipokines to enhance insulin sensitivity in patients with Alzheimer's disease dementia (AD). We aimed to investigate whether ACE gene polymorphisms rs1800764 and rs4291 are associated with cognitive and functional change in patients with AD, while also taking APOE haplotypes and anti-hypertensive treatment with ACEis into account for stratification...
October 16, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29032015/possible-positive-effect-of-the-apoe-%C3%AE%C2%B52-allele-on-cognition-in-early-to-mid-adult-life
#10
Lindsey I Sinclair, Christopher W Pleydell-Pearce, Ian N M Day
BACKGROUND: ε4 allele possession is associated with an increased risk of Alzheimer's disease. Its effects earlier in life are less well understood. Previous studies have reported both detrimental effects and a lack of effect on cognition outside dementia. We used genotype based recall from the ALSPAC study to investigate whether APOE genotype influences cognition in earlier adult life. METHODS: We invited all individuals with the rarer ε22 or ε44 genotypes and equal numbers of those with ε32, ε33 or ε34 APOE genotypes (total n invited = 1936, ages 23-67)...
October 12, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29020174/the-impact-of-statin-and-ace-inhibitor-angiotensin-receptor-blocker-therapy-on-cognitive-function-in-adults-with-hiv-infection
#11
Kristine M Erlandson, Douglas Kitch, William C Wester, Robert C Kalayjian, Edgar Turner Overton, Jose Castillo-Mancilla, Susan L Koletar, Constance A Benson, Thomas B Campbell, Kevin Robertson, Judith J Lok
Background: Although statins and angiotensin converting enzyme inhibitor or angiotensin receptor blockers (ACE/ARB) are generally well-tolerated, the impact of these therapies individually or in combination on the change in neurocognitive function in HIV-infected persons is unknown. Methods: ACTG ALLRT cohort participants not on a statin or ACE/ARB within 30 days of first neurologic assessment (baseline), with assessments by NPZ-3 (z-score of averaged Trailmaking [Tr] A and B, and digit symbol test [DST]) from ≥2 measurements were included...
July 27, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28985729/a-novel-bedside-cardiopulmonary-physical-diagnosis-curriculum-for-internal-medicine-postgraduate-training
#12
Brian Thomas Garibaldi, Timothy Niessen, Allan Charles Gelber, Bennett Clark, Yizhen Lee, Jose Alejandro Madrazo, Reza Sedighi Manesh, Ariella Apfel, Brandyn D Lau, Gigi Liu, Jenna VanLiere Canzoniero, C John Sperati, Hsin-Chieh Yeh, Daniel J Brotman, Thomas A Traill, Danelle Cayea, Samuel C Durso, Rosalyn W Stewart, Mary C Corretti, Edward K Kasper, Sanjay V Desai
BACKGROUND: Physicians spend less time at the bedside in the modern hospital setting which has contributed to a decline in physical diagnosis, and in particular, cardiopulmonary examination skills. This trend may be a source of diagnostic error and threatens to erode the patient-physician relationship. We created a new bedside cardiopulmonary physical diagnosis curriculum and assessed its effects on post-graduate year-1 (PGY-1; interns) attitudes, confidence and skill. METHODS: One hundred five internal medicine interns in a large U...
October 6, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28982269/d-allele-of-insertion-deletion-polymorphism-at-angiotensin-converting-enzyme-gene-is-associated-with-reduced-prevalence-and-severity-of-depression-among-chinese-adolescents-at-early-stage-after-wenchuan-earthquake
#13
Mei Fan, Ting Cao, Yue Feng, Mi Su, Jia Lin, Mao Sheng Ran, Ding Zhi Fang
OBJECTIVE: The purpose of the present study was to longitudinally investigate the association of insertion/deletion (I/D) polymorphism at angiotensin-converting enzyme gene (ACE) with depression in Chinese adolescents experiencing the 2008 Wenchuan earthquake. METHODS: Variants of ACE I/D were identified by polymerase chain reaction and verified by DNA sequencing. Depression symptoms were assessed by the Beck Depression Inventory (BDI) among high school students at 6, 12 and 18 months after the earthquake...
October 6, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28941921/external-validation-of-contact-surface-area-as-a-predictor-of-post-operative-renal-function-in-patients-undergoing-partial-nephrectomy
#14
Miki Haifler, Benjamin T Ristau, Andrew M Higgins, Marc C Smaldone, Alexander Kutikov, Amnon Zisman, Robert G Uzzo
PURPOSE: To externally validate a mathematical formula for tumor contact surface area (CSA) as a predictor of post-operative renal function in patients undergoing partial nephrectomy for renal cell carcinoma. MATERIALS AND METHODS: A prospectively maintained kidney cancer database was queried for patients who underwent partial nephrectomy between 2014 and 2016. CSA was calculated using data obtained from pre-operative cross sectional imaging. The correlation between CSA and peri-operative variables was examined...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28941143/the-association-between-specific-types-of-childhood-adversity-and-attenuated-psychotic-symptoms-in-a-community-sample
#15
David Mongan, Ciaran Shannon, Donncha Hanna, Adrian Boyd, Ciaran Mulholland
AIM: This study aimed to examine the relationship between types of childhood adversity and attenuated psychotic symptoms in a general population sample, and to determine the predictive role of other psychosocial factors such as resilience, coping style and social support. METHODS: An online survey was conducted with a US-based general population sample of 748 participants (aged 18 to 35 years) using Amazon's Mechanical Turk (an online crowd-sourcing service). Participants completed the Adverse Childhood Experiences Questionnaire (ACE-Q), the Prodromal Questionnaire (PQ-16), the Brief COPE Scale, the Brief Resilience Scale (BRS), the Multidimensional Scale of Perceived Social Support and the Neighbourhood Cohesion Scale...
September 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28936020/predictors-of-depressive-symptoms-in-emerging-adulthood-in-a-low-income-urban-cohort
#16
Christina F Mondi, Arthur J Reynolds, Suh-Ruu Ou
This study examined predictors of depressive symptoms in emerging adulthood in a sample of 1,142 individuals (94% African American) who grew up in urban poverty. Data were drawn from a longitudinal study that followed participants from age five and included participant, parent, and teacher surveys, and administrative records. Depressive symptoms were self-reported at age 22-24 using a modified version of the Brief Symptom Inventory (BSI; Derogatis, 1975). Binary logistic regression analyses identified several significant predictors of depressive symptoms in emerging adulthood, including: sex, adverse childhood experiences (ACE) score, socio-emotional adjustment in the classroom, juvenile arrest, and on-time graduation...
May 2017: Journal of Applied Developmental Psychology
https://www.readbyqxmd.com/read/28927940/chronic-school-absenteeism-and-the-role-of-adverse-childhood-experiences
#17
Hilary Stempel, Matthew Cox-Martin, Michael Bronsert, L Miriam Dickinson, Mandy A Allison
OBJECTIVE: To examine the association between chronic school absenteeism and adverse childhood experiences (ACEs) among school-aged children. METHODS: We conducted a secondary analysis of data from the 2011-2012 National Survey of Children's Health including children 6-17 years old. The primary outcome variable was chronic school absenteeism (> 15 days absent in past year). We examined the association between chronic school absenteeism and ACEs using logistic regression with weighting for individual ACEs, summed ACE score, and latent class analysis of ACEs...
September 16, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28912299/the-test-your-memory-for-mild-cognitive-impairment-tym-mci
#18
Jeremy M Brown, Claire J Lansdall, Julie Wiggins, Kate E Dawson, Kristina Hunter, James B Rowe, Richard A Parker
BACKGROUND: To validate a short cognitive test: the Test Your Memory for Mild Cognitive Impairment (TYM-MCI) in the diagnosis of patients with amnestic mild cognitive impairment or mild Alzheimer's disease (aMCI/AD). METHODS: Two hundred and two patients with mild memory problems were recruited. All had 'passed' the Mini-Mental State Examination (MMSE). Patients completed the TYM-MCI, the Test Your Memory test (TYM), MMSE and revised Addenbrooke's Cognitive Examination (ACE-R), had a neurological examination, clinical diagnostics and multidisciplinary team review...
September 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28888350/anterior-cingulate-cortex-grey-matter-volume-abnormalities-in-adolescents-with-ptsd-after-childhood-sexual-abuse
#19
Mirjam A Rinne-Albers, J Nienke Pannekoek, Marie-José van Hoof, Natasja D van Lang, Francien Lamers-Winkelman, Serge A Rombouts, Nic J van der Wee, Robert R Vermeiren
Adverse childhood experiences (ACE) substantially increase the risk of later psychiatric and somatic pathology. While neurobiological factors are likely to play a mediating role, specific insights are lacking. The scarce neuroimaging studies in traumatised pediatric populations have provided inconsistent results, potentially due to the inclusion of different types of trauma. To further improve our understanding of the neurobiology of pediatric psychotrauma, this study seeks to investigate abnormalities in grey matter volume (GMV) in a homogeneous group of adolescents with posttraumatic stress disorder (PTSD) due to childhood sexual abuse (CSA) and the relationship between GMV and symptom severity...
September 6, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28881542/-study-of-association-between-adverse-experiences-in-childhood-social-support-and-physical-and-psychological-sub-health-status-among-middle-school-students-in-3-cities-in-china
#20
Y H Wan, S S Ma, S J Xu, S C Zhang, J H Hao, F B Tao
Objective: To explore the relationship between adverse experience in childhood, social support, and physical and psychological sub-health status among middle school students in 3 cities in China. Methods: 15 278 adolescents were selected as subjects from 20 junior and senior middle schools located in 3 cities of China by stratified cluster sampling method. The survey collected the demographic information, ACEs, social support and physical-psychological status. A total of 14 820 valid questionnaires were retained for analysis...
September 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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