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JOURNAL ARTICLE
Vikas Tiwari, Mohd Afzal, Abhishek Sharma, Jaishree Tiwari
BACKGROUND OBJECTIVES: Dengue fever is a mosquito-borne illness that affects millions of people worldwide every year. With no vaccination available, early detection and treatment is critical. One-hundred-twelve countries in the world pose a risk to travelers, particularly in metropolitan areas. Laboratory diagnoses vary according to objectives, resources, and schedule, with sensitivity and specificity must be balanced for effective testing. METHODS: The current work is a cross-sectional diagnostic study and samples from suspected patients of dengue was collected from May 15 to November 15 2023 and transported to laboratory, and RT-PCR and Dengue Duo Rapid test diagnosis techniques were used on 48 clinical samples included in this study...
April 18, 2024: Journal of Vector Borne Diseases
#22
JOURNAL ARTICLE
Tien-Ru Huang, Chun-Shu Lin, Hsin-Chien Chen
Solitary bone plasmacytoma (SBP) is a rare hematological malignancy that usually occurs in the spine and rarely in the skull. It rarely presents in the skull base, but presenting symptoms are associated with cranial nerve involvement depending on the site of the disease. We present the case of a 61-year-old man with an unusual presentation of hoarseness secondary to vocal fold palsy. Imaging showed a large bony lesion in the temporo-occipital region with involvement of the jugular foramen. Further detailed diagnostic procedures confirmed SBP of the skull base...
April 18, 2024: Ear, Nose, & Throat Journal
#23
JOURNAL ARTICLE
Shrita Sarkar, Chandan Seth, Mainak Dutta, Saumendra Nath Bandyopadhyay
A 24-year-old man with von Recklinghausen's disease presented with complaints of difficulty in swallowing for 6 months and change of voice for 3 months. He also had recent-onset difficulty in breathing. Telelaryngoscopy and subsequent contrast-enhanced computed tomography scan revealed a well-defined, smooth submucosal mass in the oropharynx (attached to the posterior pharyngeal wall, superior to the level of left aryepiglottic fold), obscuring the ipsilateral pyriform fossa, and nearly blocking the pharyngeal lumen...
April 18, 2024: Ear, Nose, & Throat Journal
#24
REVIEW
Richard K Cheng, Michelle M Kittleson, Craig J Beavers, David H Birnie, Ron Blankstein, Paco E Bravo, Nisha A Gilotra, Marc A Judson, Kristen K Patton, Leonie Rose-Bovino
Cardiac sarcoidosis is an infiltrative cardiomyopathy that results from granulomatous inflammation of the myocardium and may present with high-grade conduction disease, ventricular arrhythmias, and right or left ventricular dysfunction. Over the past several decades, the prevalence of cardiac sarcoidosis has increased. Definitive histological confirmation is often not possible, so clinicians frequently face uncertainty about the accuracy of diagnosis. Hence, the likelihood of cardiac sarcoidosis should be thought of as a continuum (definite, highly probable, probable, possible, low probability, unlikely) rather than in a binary fashion...
April 18, 2024: Circulation
#25
JOURNAL ARTICLE
Gillian P Jackson, Catriona E Jackson, Jason W Boland, Imogen Featherstone, Chao Huang, Margaret Ogden, Kathryn Sartain, Najma Siddiqi, Maureen Twiddy, Mark Pearson, Miriam J Johnson
BACKGROUND: Delirium is a complex condition, stressful for all involved. Although highly prevalent in palliative care settings, it remains underdiagnosed and associated with poor outcomes. Guideline-adherent delirium care may improve its detection, assessment and management. AIM: To inform a future definitive study that tests whether an implementation strategy designed to improve guideline-adherent delirium care in palliative care settings improves patient outcomes (reduced proportion of in-patient days with delirium)...
April 2024: Palliative Medicine
#26
Satomi Mizutani, Hidehiko Kuribayashi, Noriyuki Saeki, Hideki Ito, Yasutaka Nakamura, Makoto Masuda, Yoshito Kamio, Masashi Kawamoto, Tatsuji Enomoto
KEY CLINICAL MESSAGE: Even in the absence of other symptoms or other pulmonary manifestations suggesting Sjögren's syndrome (SS), it is necessary to include SS in the differential diagnosis of diffuse cystic lung disease (CLD). ABSTRACT: A case of SS that presented initially with diffuse CLD is reported. This case is considered rare because diffuse pulmonary cysts were observed in the early stage with few symptoms, only cysts were observed without other lung lesions on imaging, cyst formation was histologically considered to be alveolar loss, and airway lesions not observed on imaging were suspected based on lung function testing...
April 2024: Clinical Case Reports
#27
Samuel Addisu Abera, Amanuel Kassa Tadesse, Kirubel Addisu Abera, Kassa Berie Zegeye, Mohammed Alemu Ibrahim, Ashenafi Amsalu Feleke, Cheru Lilay Gebrehiwet, Segenet Bizuneh Mengistu, Hirut Tesfahun Alemu, Yohannis Derbew Molla
KEY CLINICAL MESSAGE: Duodenal GISTs are rare and challenging tumors. Acute life-threatening upper GI bleeding is a possible presentation of duodenal GISTs. Surgery is the standard treatment for localized duodenal GISTs. Imatinib is an effective adjuvant therapy for duodenal GISTs. ABSTRACT: GIST is the most common mesenchymal neoplasm of the gastrointestinal tract, accounting for 1%-2% of gastrointestinal tumors. They originate from the interstitial cells of Cajal and are rare in patients younger than 30 years...
April 2024: Clinical Case Reports
#28
Alex José Castellón Méndez, Allan Bodán Campbell, Victor Rosales Obregón, Mohammed Zahran
KEY CLINICAL MESSAGE: Rare yet significant, this case sheds light on the uncommon presentation of Waldmann's disease in adults, showcasing the diagnostic challenges it poses. A multidisciplinary approach, integrating clinical, endoscopic, histological, and radiological evaluations, is crucial for accurate diagnosis and management. Further research is needed to deepen our understanding of this complex disorder. ABSTRACT: Waldmann's disease, or primary intestinal lymphangiectasia, is a rare disorder characterized by protein-losing enteropathy due to dilation and leakage of intestinal lymphatic vessels...
April 2024: Clinical Case Reports
#29
JOURNAL ARTICLE
Emily Fitzgerald, Shelby Parker, Sarah Hancock, Courtney Marie-Cora Jones, Julie Kittel, John DeAngelis, Maia Dorsett
OBJECTIVES: Patients with chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF) exacerbations present with similar history and physical examination findings. This complicates both the diagnostic process and the creation of appropriate treatment plans for patients presenting in respiratory distress, particularly in the prehospital setting. Thoracic point-of-care-ultrasound (POCUS) may increase diagnostic accuracy; however, its potential to improve patient management by emergency medical services clinicians is unknown...
April 2024: Journal of the American College of Emergency Physicians open
#30
Marwan Alaswad, Abdullah Al Otry, Ziad Alhosainy, Fadwa Elkordy, Belal Nedal Sabbah, Tarek Ziad Arabi, Humzah Abdulkader, Obaida Fadi Ghanayem, Ayman Zaki Azzam, Tarek Amin
Gallbladder cancer (GBC) is a rare and highly aggressive malignancy, often characterized by nonspecific clinical presentations and late diagnosis, which contribute to its poor prognosis. It is commonly detected at advanced stages, leading to low survival rates. Surgical resection is the primary treatment, with the extent of surgery depending on the T stage of the cancer. In advanced cases, surgery is only considered if it can potentially be curative. Despite various treatment approaches for advanced GBC, survival outcomes remain poor...
2024: Frontiers in Oncology
#31
JOURNAL ARTICLE
Juan Carlos Núñez-Enríquez, Rubí Romo-Rodríguez, Pedro Gaspar-Mendoza, Gabriela Zamora-Herrera, Lizeth Torres-Pineda, Jiovanni Amador-Cardoso, Jebea A López-Blanco, Laura Alfaro-Hernández, Lucero López-García, Arely Rosas-Cruz, Dulce Rosario Alberto-Aguilar, César Omar Trejo-Pichardo, Dalia Ramírez-Ramírez, Astin Cruz-Maza, Janet Flores-Lujano, Nuria Luna-Silva, Angélica Martínez-Martell, Karina Martínez-Jose, Anabel Ramírez-Ramírez, Juan Carlos Solis-Poblano, Patricia Zagoya-Martínez, Vanessa Terán-Cerqueda, Andrea Huerta-Moreno, Álvaro Montiel-Jarquín, Miguel Garrido-Hernández, Raquel Hernández-Ramos, Daniela Olvera-Caraza, Cynthia Shanat Cruz-Medina, Enoch Alvarez-Rodríguez, Lénica Anahí Chávez-Aguilar, Wilfrido Herrera-Olivares, Brianda García-Hidalgo, Lena Sarahí Cano-Cuapio, Claudia Guevara-Espejel, Gerardo Juárez-Avendaño, Juan Carlos Balandrán, Ma Del Rocío Baños-Lara, Mariana Cárdenas-González, Elena R Álvarez-Buylla, Sonia Mayra Pérez-Tapia, Diana Casique-Aguirre, Rosana Pelayo
The main objective of the National Project for Research and Incidence of Childhood Leukemias is to reduce early mortality rates for these neoplasms in the vulnerable regions of Mexico. This project was conducted in the states of Oaxaca, Puebla, and Tlaxcala. A key strategy of the project is the implementation of an effective roadmap to ensure that leukemia patients are the target of maximum benefit of interdisciplinary collaboration between researchers, clinicians, surveyors, and laboratories. This strategy guarantees the comprehensive management of diagnosis and follow-up samples of pediatric patients with leukemia, centralizing, managing, and analyzing the information collected...
2024: Frontiers in Oncology
#32
JOURNAL ARTICLE
Jordy van Enkhuizen, Jean Binns, April Betts, Fatemeh Saberi Hosnijeh, Myriam Alexander, Mark McCormack, Saiju Jacob
BACKGROUND: There are limited data on the real-world healthcare resource use (HCRU) and management costs of myasthenia gravis (MG) in England. OBJECTIVE: This study aims to assess the burden of disease for patients with MG in England. DESIGN: A retrospective, observational cohort study of adult patients diagnosed with MG, using data from the Hospital Episode Statistics data warehouse. METHODS: Patients with a first-ever recorded diagnosis of MG between 30 June 2015 and 30 June 2020 were followed up until 30 June 2021 or death, whichever occurred first...
2024: Therapeutic Advances in Neurological Disorders
#33
REVIEW
Hsuan-Wei Liu, Oscar Kuang-Sheng Lee
BACKGROUND: Elastic band exercises can improve bone density, muscle quality, and body fat in elderly patients with Sarcopenic Obesity Syndrome (SOS), a common diagnosis. Encouraging this exercise can bring significant benefits. METHODS: We conducted a comprehensive search until April 1, 2023, covering UpToDate, PubMed, and Web of Science databases. The analysis focused on osteosarcopenic obesity and resistance training, involving four randomized controlled trials with 108 participants...
July 2024: Journal of Orthopaedics
#34
JOURNAL ARTICLE
Toyoshi Yanagihara, Hikaru Hatashima, Hiroaki Ogata, Yuki Moriuchi, Akiko Ishimatsu, Junji Otsuka, Kazuhito Taguchi, Atushi Moriwaki, Makoto Yoshida
Amyloidosis presents a diagnostic challenge, particularly when concomitant with severe conditions like acute exacerbations of idiopathic pulmonary fibrosis (IPF). In this report, we detail the case of a 73-year-old patient with acute exacerbation of IPF and simultaneous emergence of cardiac amyloidosis. The patient's clinical journey began with persistent exertional dyspnea, progressing to hypoxemia on admission. Chest CT scans showed extensive ground-glass opacities, consolidations, and pre-existing honeycombing-like cysts and reticular shadows, accompanied by a right-sided pleural effusion...
March 2024: Curēus
#35
Sayan Malakar, Nishant Shah, Ankit Mishra, Vipin Pandey, Vivek V Shirol, Naganath K Wodeyar, Prabhat Verma, Sai Prathap, Kartik Balankhe, Ramnawal Rao, Uday C Ghoshal
Acute viral hepatitis E (HEV) is the most common form of acute viral hepatitis in India. It is associated with self-limiting disease in most cases. However, the chronic form of HEV is also being increasingly recognized. Other viral infections like the hepatitis A virus (HAV) have been implicated in inciting autoimmune hepatitis. HEV infection has been associated with the formation of circulating liver-directed autoantibodies, however autoimmune liver disease following acute HEV infection has been rarely reported...
March 2024: Curēus
#36
Juan D Ayala Torres, Santiago Andrés Gómez Salazar, Juan Gonzalo Vélez Zuluaga
The presented case describes a 56-year-old male with adult-onset Still's disease, exhibiting polyserositis in 2019, who underwent pleurectomy and pericardiectomy. Despite treatment with tocilizumab and methylprednisolone, the patient developed deep vein thrombosis and pulmonary embolism in 2022, managed with apixaban. A contrast-enhanced chest tomography revealed no recurrent thromboembolic events. Over a year, the patient experienced progressive dyspnea, correlating with signs of constriction on transthoracic echocardiogram...
March 2024: Curēus
#37
John K Jung, Anne C Chan, Rodney Guiseppi, Brian Wong
In this case report, we present an unusual complication linked to a hydrogel explant in a 72-year-old male presenting to the emergency department with persistent left eye pain, redness, and discharge for one month. The patient had a history of retinal detachment in 1989, which was managed with scleral buckle surgery and gas injection. Initial examination revealed an extruding scleral buckle in the superior temporal region, along with signs of an infection. CT scans revealed a 1.9 × 1.2 × 3.8 cm abscess accompanied by preseptal cellulitis...
March 2024: Curēus
#38
Shafiq Tanveer, Asna Tahir, Obaid Ahmad, Kainat Bibi, Samreen Khan
Myasthenia gravis (MG) is an autoimmune disorder characterized by fluctuating weakness and fatigue in ocular, bulbar, limb, or respiratory muscles. Initially, more than half of MG patients experience isolated ocular symptoms, such as ptosis, diplopia, or muscle paresis. This case report presents a unique occurrence of MG in a four-year-old female, showcasing a two-year history of sudden onset, persistent yet fluctuating unilateral ptosis accompanied by exo-deviation and adduction deficit in the right eye...
March 2024: Curēus
#39
Kevin Kawde, Gajanan Pisulkar, Ankur Salwan, Adarsh Jayasoorya, Vivek H Jadawala, Aditya Chirayath
Prosthetic joint infection (PJI) remains a significant complication following joint arthroplasty, necessitating prompt recognition and intervention to optimize patient outcomes. This case report describes a 65-year-old male who presented with persistent pain, swelling, and purulent discharge from the right hip, three years post-bipolar hemiarthroplasty following a road traffic accident. Clinical examination revealed signs suggestive of PJI, prompting surgical intervention with total hip arthroplasty. Postoperatively, the patient experienced resolution of symptoms and satisfactory recovery...
March 2024: Curēus
#40
JOURNAL ARTICLE
Asmae Squalli Houssaini, Salma Lamrabet, Nadia Senhaji, Mohammed Sekal, Jean Paul Nshizirungu, Hajar Mahfoudi, Samira Elfakir, Mehdi Karkouri, Sanae Bennis
INTRODUCTION: Glioblastoma and astrocytoma, grade 4, are the most common and aggressive brain tumors. Several biomarkers, such as the isocitrate dehydrogenase mutation (IDH-1), alpha-thalassemia/mental retardation, and the X-linked mutation (ATRX), enable more accurate glioma classification and facilitate patient management. This study aimed to determine the prognostic value of clinical and molecular factors (IDH, TP53, and ATRX mutations). We also studied the relationship between these molecular markers and the overall survival (OS) of 126 patients with grade 4 glioblastoma/astrocytoma...
March 2024: Curēus
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