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https://www.readbyqxmd.com/read/28330082/mutations-in-the-plastidic-accase-gene-endowing-resistance-to-accase-inhibiting-herbicide-in-phalaris-minor-populations-from-india
#1
Nishu Raghav, Rajender Singh, Rajender Singh Chhokar, Davinder Sharma, Raman Kumar
Littleseed canarygrass (Phalaris minor Retz.) is one of the most common and troublesome weeds infesting wheat crop in India. Repeated use during the last two decades of the ACCase-inhibiting herbicide (clodinafop) to control this weed has resulted in the occurrence of resistance. Fifty-three P. minor populations were collected from wheat fields in Haryana and Punjab states of India. The dose-response assays indicated that 29 populations were resistant, 23 populations were susceptible and one population was moderately resistant to clodinafop...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330019/facial-nerve-tractography-a-new-tool-to-detect-perineural-invasion-in-parotid-cancers
#2
René-Charles Rouchy, Arnaud Attyé, Irène Troprès, Maud Medici, Adrian Kastler, Christian Righini, Alexandre Krainik
PURPOSE: To determine whether magnetic resonance (MR) tractography of facial nerve (VIIn) is useful to detect perineural invasion in case of parotid cancers. MATERIALS AND METHODS: Thirty patients, aged 18 or over, were enrolled in this prospective study between December 2013 and March 2016 (IRB 5891), with a diagnosis of parotid tumors (15 malignant, 15 benign). They have undergone preoperative MR scans (3.0-T) before surgical management. The parameters of the diffusion-weighted (DW) sequence were b-value of 1000s/mm(2); 32 directions; voxel size: 2mm isotropic; scan time: 9' The post-processing generates whole-neck constrained spherical deconvolution (CSD)-based tractography data and super-resolution track-weighted imaging (TWI) technique...
March 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28329651/infections-in-children-with-eczema-in-uk-general-practice-a-cohort-study
#3
Sinéad M Langan, Katrina Abuabara, Sarah E Henrickson, Ole Hoffstad, David J Margolis
BackgroundCase reports and cross-sectional studies suggest increased risks of cutaneous and non-cutaneous infections in eczema; this relationship needs to be assessed in large population-based studies with diagnostic confirmation. The objective was to examine associations between eczema and common childhood infections.MethodsIndividuals registered prior to age 18 in the Health Improvement Network, a UK general practice database, from 2003 to 2013 were included in this cohort study. We determined the association between eczema and selected infectious outcomes, including cutaneous (dermatophyte, herpes simplex virus, impetigo, molluscum contagiosum and warts), and non-cutaneous infections (otitis media, streptococcal throat infections, and pneumonia)...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329639/development-and-validation-of-the-basal-and-squamous-cell-carcinoma-quality-of-life-basqol-questionnaire
#4
Rick Waalboer-Spuij, Loes M Hollestein, Reinier Timman, Lonneke V Van de Poll-Franse, Tamar E C Nijsten
Health-related quality of life is increasingly important in the management of patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). A few disease-specific questionnaires exist, but all with substantial flaws. We developed and validated a quality of life questionnaire suitable for use in all BCC and SCC patients. In an extensive four-phase trajectory, as recommended by the European Organisation for Research and Treatment of Cancer (EORTC), 33 items were selected and rephrased into a preliminary questionnaire...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329582/cyclosporine-in-toxic-epidermal-necrolysis-a-brief-review-of-the-emerging-therapeutic-modality
#5
Piyush Kumar, Nilay Kanti Das
Toxic epidermal necrolysis (TEN) is a severe life-threatening adverse drug reaction that predominantly involve the skin and mucous membranes, and is associated with high mortality (25-35% or even higher) and with various long term sequelae. There is no universally accepted treatment for TEN, but key elements of management include rapid diagnosis, identification and interruption of the culprit drug, evaluation of the prognosis using SCORTEN, specialized supportive care ideally in an intensive care unit, and consideration of immunomodulating agents...
October 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329579/habit-tic-nail-deformity-a-rare-presentation-in-an-8-year-old-boy
#6
S El-Heis, Al Abadie
Habit tic nail deformity is a nail dystrophy resulting from habitual, repetitive trauma to the nail. It is usually acquired in adulthood, however, we report a case of habit tic nail deformity in an 8 year old boy. The diagnosis was made clinically with further history revealing that the boy repeatedly rubbed his thumbnails and pushed the cuticles. Emollient cream (Balneum®) was recommended twice daily and both the patient and his mother were educated on the behavioral nature of this condition. There was marked improvement at 6 months of treatment and further improvement at 12 months...
November 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329519/tnf-inhibitor-induced-alopecia-an-unusual-form-of-psoriasiform-alopecia-that-breaks-the-renb%C3%A3-k-mold
#7
Lauren N Craddock, Matthew Cooley, Justin O Endo, B Jack Longley, Freddy Caldera
TNF-α-inhibitors are known to induce skin adverseeffects including psoriasis and alopecia areata. Here, wedescribe a unique pattern of hair loss that has psoriaticand alopecia areata-like features. Diagnosis requiresclinical-pathologic correlation and is supportedby increased catagen/telogen hairs, psoriasiformepidermal hyperplasia, perifollicular lymphocyticinfiltrate, and the presence of eosinophils and plasmacells. Although there are no treatment consensusguidelines, management options include stoppingtherapy, switching to a different TNF-α inhibitor orustekinumab (in severe cases), or continuing TNF-αinhibitor therapy with addition of topical, intralesional,or systemic immunosuppressants...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329481/cutaneous-leishmaniasis-mimicking-squamous-cell-carcinoma
#8
Tara Oetken, Bryan Hiscox, Ida Orengo, Theodore Rosen
A 41-year-old man from Cuero, Texas with a nonhealinglesion on his left cheek was referred to ourclinic for removal of a squamous cell carcinoma. Thepatient first noticed a "pimple" on his left cheek 3-4months prior to presentation. When the lesion beganto grow he presented to his primary care physician anda biopsy was taken, showing "atypical squamous cellproliferation." Mohs surgery was performed and thenodule was removed with no evidence of malignancyseen on histopathology. Upon review of the surgicalbiopsies by consulting pathologists, the diagnosis ofleishmaniasis was established and later confirmed bythe Center for Disease Control and Prevention (CDC)as Leishmania mexicana...
January 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329417/nursing-judgement-and-decision-making-using-the-sedation-withdrawal-score-sws-in-children
#9
Jennie Craske, Bernie Carter, Ian H Jarman, Lyvonne N Tume
AIMS: The aim of the study was to evaluate registered children's nurses' approaches to the assessment and management of withdrawal syndrome in children. BACKGROUND: Assessment of withdrawal syndrome is undertaken following critical illness when the child's condition may be unstable with competing differential diagnoses. Assessment tools aim to standardise and improve recognition of withdrawal syndrome. Making the right decisions in complex clinical situations requires a degree of mental effort and it is not known how nurses make decisions when undertaking withdrawal assessments...
March 22, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28329372/practical-review-of-recognition-and-management-of-obesity-and-lipohypertrophy-in-hiv-infection
#10
Jordan E Lake, Takara Stanley, Caroline Apovian, Shalendar Bhasin, Todd T Brown, Jaqueline Capeau, Judith S Currier, Michael P Dube, Julian Falutz, Steven K Grinspoon, Giovanni Guaraldi, Esteban Martinez, Grace A McComsey, Fred R Sattler, Kristine M Erlandson
Background: Obesity and lipohypertrophy are common in treated HIV infection and contribute to morbidity and mortality among HIV-infected adults on antiretroviral therapy (ART). Methods: We present a consensus opinion on the diagnosis, clinical consequences and treatment of excess adiposity in adults with treated HIV infection. Results: Obesity and lipohypertrophy commonly occur among HIV-infected adults on ART, and may have overlapping pathophysiologies and/or synergistic metabolic consequences...
February 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28329307/eacvi-appropriateness-criteria-for-the-use-of-transthoracic-echocardiography-in-adults-a-report-of-literature-and-current-practice-review
#11
Richard P Steeds, Madalina Garbi, Nuno Cardim, Jaroslaw D Kasprzak, Elif Sade, Petros Nihoyannopoulos, Bogdan Alexandru Popescu, Alexandros Stefanidis, Bernard Cosyns, Mark Monaghan, Svend Aakhus, Thor Edvardsen, Frank Flachskampf, Leonarda Galiuto, George Athanassopoulos, Patrizio Lancellotti
The European Association for Cardiovascular Imaging (EACVI) has outlined the rationale for setting appropriate use criteria (AUC) in cardiovascular (CV) imaging. Transthoracic echocardiography (TTE) is the most common imaging modality in CV disease and is a central tool in diagnosis, follow-up, management planning and intervention. The purpose of AUC is to inform referrers, both to avoid under-use, which may result in incomplete or incorrect diagnosis and treatment, and also over-use, which may delay correct diagnosis, lead to 'treatment cascade', and wastes resources...
February 25, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28329262/diagnosis-and-management-of-acute-deep-vein-thrombosis-a-joint-consensus-document-from-the-european-society-of-cardiology-working-groups-of-aorta-and-peripheral-circulation-and-pulmonary-circulation-and-right-ventricular-function
#12
Lucia Mazzolai, Victor Aboyans, Walter Ageno, Giancarlo Agnelli, Adriano Alatri, Rupert Bauersachs, Marjolein P A Brekelmans, Harry R Büller, Antoine Elias, Dominique Farge, Stavros Konstantinides, Gualtiero Palareti, Paolo Prandoni, Marc Righini, Adam Torbicki, Charalambos Vlachopoulos, Marianne Brodmann
No abstract text is available yet for this article.
February 17, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28329034/use-of-pfhrp2-only-rdts-rapidly-select-for-pfhrp2-negative-parasites-with-serious-implications-for-malaria-case-management-and-control
#13
Michelle L Gatton, Jessica Dunn, Alisha Chaudhry, Sadmir Ciketic, Jane Cunningham, Qin Cheng
Background: Rapid diagnostic tests (RDTs) are an important tool for malaria diagnosis, with most utilising antibodies against histidine-rich protein 2 (PfHRP2). Reports of Plasmodium falciparum lacking this protein are increasing, creating a problem for diagnosis of falciparum malaria in locations without quality microscopy. Methods: An agent-based stochastic simulation model of P.falciparum transmission was used to investigate the selective pressure exerted on parasite populations by use of RDTs for diagnosis of symptomatic cases...
March 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28328942/the-value-of-theory-in-programmes-to-implement-clinical-guidelines-insights-from-a-retrospective-mixed-methods-evaluation-of-a-programme-to-increase-adherence-to-national-guidelines-for-chronic-disease-in-primary-care
#14
Jessica Sheringham, Francesca Solmi, Cono Ariti, Abigail Baim-Lance, Steve Morris, Naomi J Fulop
BACKGROUND: Programmes have had limited success in improving guideline adherence for chronic disease. Use of theory is recommended but is often absent in programmes conducted in 'real-world' rather than research settings. MATERIALS AND METHODS: This mixed-methods study tested a retrospective theory-based approach to evaluate a 'real-world' programme in primary care to improve adherence to national guidelines for chronic obstructive pulmonary disease (COPD). Qualitative data, comprising analysis of documents generated throughout the programme (n>300), in-depth interviews with planners (clinicians, managers and improvement experts involved in devising, planning, and implementing the programme, n = 14) and providers (practice clinicians, n = 14) were used to construct programme theories, experiences of implementation and contextual factors influencing care...
2017: PloS One
https://www.readbyqxmd.com/read/28328806/craniosynostosis-scheuermann-s-disease-and-intellectual-disability-resembling-shprintzen-goldberg-syndrome-a-report-on-a-family-over-4-generations-case-report
#15
Ali Al Kaissi, Zahra Marrakchi, Nabil M Nassib, Jochen Hofstaetter, Franz Grill, Rudolf Ganger, Susanne Gerit Kircher
RATIONALE: Craniosynostosis is a disorder characterized by premature fusion of cranial sutures with subsequent development of abnormal craniofacial contour associated with variable skeletal and extra-skeletal abnormalities. In this family syndromic type of craniosynostosis was recognized and the etiology behind diverse forms of deformities have been diagnosed. PATIENT CONCERNS: The negative impact of the disorder on the child and his family is enormous. Particularly when the diagnosis is late and little can be done...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328693/a-giant-pseudoaneurysm-mimicking-retropharyngeal-abscess-in-a-child
#16
Rijuneeta Gupta, Sourabha K Patro, Neha Chauhan, Ajay Kumar
Pseudoaneurysms of the cervical internal carotid artery are rare and usually result from trauma, infection, or rarely spontaneously. They harbor potential risk of life-threatening hemorrhage and warrant immediate management. Endovascular treatment in the form of stent placement and coiling is a well established technique for dealing with both intracranial and extracranial pseudoaneurysms. We present a case of a child who presented with fever, neck swelling, dysphagia, and respiratory distress in emergency for which clinical diagnosis of a neck abscess was made...
March 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28328650/exosomes-in-critical-illness
#17
Nora Terrasini, Vincenzo Lionetti
OBJECTIVE: Exosomes are small, cell-released vesicles (40-100 nm in size) with the potential to transfer proteins, lipids, small RNAs, messenger RNAs, or DNA between cells via interstitial fluids. Due to their role in tissue homeostasis, exosomes have emerged as a new type of therapeutic and diagnostic (theranostic) tool in the noninvasive assessment of organ response to injury or treatment and in the development of reliable organ-protective intensive therapy. Our review provides current insights into the role of exosomes in the personalized management of injury and repair responses in critical illness...
March 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28328639/the-effect-of-furlow-palatoplasty-timing-on-speech-outcomes-in-submucous-cleft-palate
#18
Jordan W Swanson, Brianne T Mitchell, Marilyn Cohen, Cynthia Solot, Oksana Jackson, David Low, Scott P Bartlett, Jesse A Taylor
BACKGROUND: Because some patients with submucous cleft palate (SMCP) are asymptomatic, surgical treatment is conventionally delayed until hypernasal resonance is identified during speech production. We aim to identify whether speech outcomes after repair of a SMCP is influenced by age of repair. METHODS: We retrospectively studied nonsyndromic children with SMCP. Speech results, before and after any surgical treatment or physical management of the palate were compared using the Pittsburgh Weighted Speech Scoring system...
March 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28328623/a-novel-user-friendly-model-to-predict-corticosteroid-utilization-in-newly-diagnosed-patients-with-ulcerative-colitis
#19
Nabeel Khan, Dhruvan Patel, Yash Shah, Gary Lichtenstein, Yu-Xiao Yang
BACKGROUND: Corticosteroid (CS) use is an important marker of poor prognosis in ulcerative colitis (UC). Our aim was to develop and validate a model to predict the risk of CS utilization over the course of disease in newly diagnosed patients with UC. METHODS: Newly diagnosed patients with UC from a nationwide VA cohort were followed over time to evaluate factors predictive of CS use. Multivariate logistic regression was performed. Model development was performed in a random 2/3 of the total cohort and then validated in the remaining 1/3...
March 21, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28328615/patient-reported-experience-of-diagnosis-management-and-burden-of-neuroendocrine-tumors-results-from-a-large-patient-survey-in-the-united-states
#20
Edward M Wolin, John Leyden, Grace Goldstein, Teodora Kolarova, Ron Hollander, Richard R P Warner
OBJECTIVES: The aim of this survey was to examine the experience of patients with neuroendocrine tumors (NETs) to raise awareness of the NET-related burden and identify unmet needs. Here, we report data from patients in the United States. METHODS: Patients with NETs participated in a 25-minute anonymous survey, conducted primarily online from February to May 2014. Survey questions captured information on sociodemographics, clinical characteristics, NET diagnostic experience, disease impact/management, interaction with medical teams, and NETs knowledge/awareness...
March 21, 2017: Pancreas
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