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Developmental programming

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https://www.readbyqxmd.com/read/29470956/metabolomic-insights-into-the-effects-of-thyroid-hormone-on-rana-lithobates-catesbeiana-metamorphosis-using-whole-body-matrix-assisted-laser-desorption-ionization-mass-spectrometry-imaging-maldi-msi
#1
Teesha C Luehr, Emily M Koide, Xiaodong Wang, Jun Han, Christoph H Borchers, Caren C Helbing
Anuran metamorphosis involves the transformation of an aquatic tadpole into a juvenile frog. This process is completely dependent upon thyroid hormones (THs). Although much research has been focused on changes in gene expression programs during this postembryonic developmental period, transitions in the metabolic profiles are relatively poorly understood. Matrix Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging (MALDI-MSI) is a technique that generates highly multiplexed mass spectra while retaining spatial location information on a thin tissue section...
February 19, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29470117/adaptive-behavior-of-sheltered-homeless-children-in-the-french-enfams-survey
#2
Stéphane Darbeda, Bruno Falissard, Massimiliano Orri, Caroline Barry, Maria Melchior, Pierre Chauvin, Stéphanie Vandentorren
OBJECTIVES: To describe the adaptive behaviors in a large sample of homeless children and identify factors associated with developmental delay. METHODS: Data were from a cross-sectional survey of 557 children younger than 6 years randomly sampled among homeless sheltered families in the Paris, France, region (January-May 2013). An interviewer and a psychologist conducted face-to-face interviews to collect information on sociodemographic and health characteristics...
February 22, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29468683/quantification-of-complex-modular-architecture-in-plants
#3
Catherine Reeb, Jaap Kaandorp, Fredrik Jansson, Nicolas Puillandre, Jean-Yves Dubuisson, Raphaël Cornette, Florian Jabbour, Yoan Coudert, Jairo Patiño, Jean-François Flot, Alain Vanderpoorten
Morphometrics, the assignment of quantities to biological shapes, is a powerful tool to address taxonomic, evolutionary, functional and developmental questions. We propose a novel method for shape quantification of complex modular architecture in thalloid plants, whose extremely reduced morphologies, combined with the lack of a formal framework for thallus description, have long rendered taxonomic and evolutionary studies extremely challenging. Using graph theory, thalli are described as hierarchical series of nodes and edges, allowing for accurate, homologous and repeatable measurements of widths, lengths and angles...
February 22, 2018: New Phytologist
https://www.readbyqxmd.com/read/29467768/cytokine-networks-between-innate-lymphoid-cells-and-myeloid-cells
#4
REVIEW
Arthur Mortha, Kyle Burrows
Innate lymphoid cells (ILCs) are an essential component of the innate immune system in vertebrates. They are developmentally rooted in the lymphoid lineage and can diverge into at least three transcriptionally distinct lineages. ILCs seed both lymphoid and non-lymphoid tissues and are locally self-maintained in tissue-resident pools. Tissue-resident ILCs execute important effector functions making them key regulator in tissue homeostasis, repair, remodeling, microbial defense, and anti-tumor immunity. Similar to T lymphocytes, ILCs possess only few sensory elements for the recognition of non-self and thus depend on extrinsic cellular sensory elements residing within the tissue...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29467254/bdnf-activates-an-nfi-dependent-neurodevelopmental-timing-program-by-sequestering-nfatc4
#5
Baojin Ding, Paul R Dobner, Debra Mullikin-Kilpatrick, Wei Wang, Hong Zhu, Chi-Wing Chow, John W Cave, Richard M Gronostajski, Daniel L Kilpatrick
How intrinsic and extrinsic signals are coordinated to regulate synaptic maturation and its timing is an important question for neurodevelopment and its disorders. Here, we investigated the influence of the neurotrophin BDNF on the developmental timing of a dendrite/synapse-related gene program controlled by Nuclear Factor One (NFI) in maturing cerebellar granule neurons (CGNs). BDNF accelerated the onset of NFI-regulated late-gene expression and NFI temporal occupancy in CGN cultures in a MEK5/ERK5-dependent manner...
February 21, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29467246/the-transcriptome-of-early-chicken-embryo-reveal-signaling-pathways-governing-rapid-asymmetric-cellularization-and-lineage-segregation
#6
Young Sun Hwang, Minseok Seo, Bo Ram Lee, Hong Jo Lee, Young Hyun Park, Sang Kyung Kim, Hyung Chul Lee, Hee Jung Choi, Joon Yoon, Heebal Kim, Jae Yong Han
The phylogenomics and comparative functional genomics of avian species were investigated in the Bird10K project because of the important evolutionary position of birds and their value as a research model. However, the systematic profiling of transcriptional changes prior to oviposition has not been investigated in avian species because of the practical difficulties in obtaining pre-oviposited eggs. In this study, a total of 137 pre-oviposited embryos were collected from hen ovaries and oviducts and subjected to RNA sequencing analyses...
February 21, 2018: Development
https://www.readbyqxmd.com/read/29467245/lineage-and-stage-specific-expressed-cycd7-1-coordinates-the-single-symmetric-division-that-creates-stomatal-guard-cells
#7
Annika K Weimer, Juliana L Matos, Nidhi Sharma, Farah Patell, James A H Murray, Walter Dewitte, Dominique C Bergmann
Plants, with cells fixed in place by rigid walls, often utilize spatial and temporally distinct cell division programs to organize and maintain organs. This leads to the question of how developmental regulators interact with the cell cycle machinery to link cell division events with particular developmental trajectories. In Arabidopsis leaves, the development of stomata, 2-celled epidermal valves that mediate plant-atmosphere gas exchange, relies on a series of oriented stem-cell-like asymmetric divisions followed by a single symmetric division...
February 21, 2018: Development
https://www.readbyqxmd.com/read/29467242/prothoracicotropic-hormone-modulates-environmental-adaptive-plasticity-through-the-control-of-developmental-timing
#8
MaryJane Shimell, Xueyang Pan, Francisco A Martin, Arpan C Ghosh, Pierre Leopold, Michael B O'Connor, Nuria M Romero
Adult size and fitness are controlled by a combination of genetics and environmental cues. In Drosophila , growth is confined to the larval phase and final body size is impacted by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis. Here, we test this issue by examining the consequences of null mutations in the ptth gene on Drosophila development...
February 21, 2018: Development
https://www.readbyqxmd.com/read/29466941/transcription-start-site-profiling-uncovers-divergent-transcription-and-enhancer-associated-rnas-in-drosophila-melanogaster
#9
Michael P Meers, Karen Adelman, Robert J Duronio, Brian D Strahl, Daniel J McKay, A Gregory Matera
BACKGROUND: High-resolution transcription start site (TSS) mapping in D. melanogaster embryos and cell lines has revealed a rich and detailed landscape of both cis- and trans-regulatory elements and factors. However, TSS profiling has not been investigated in an orthogonal in vivo setting. Here, we present a comprehensive dataset that links TSS dynamics with nucleosome occupancy and gene expression in the wandering third instar larva, a developmental stage characterized by large-scale shifts in transcriptional programs in preparation for metamorphosis...
February 21, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29466875/impacts-of-maternal-dietary-protein-intake-on-fetal-survival-growth-and-development
#10
Cassandra M Herring, Fuller W Bazer, Gregory A Johnson, Guoyao Wu
Maternal nutrition during gestation, especially dietary protein intake, is a key determinant in embryonic survival, growth, and development. Low maternal dietary protein intake can cause embryonic losses, intra-uterine growth restriction, and reduced postnatal growth due to a deficiency in specific amino acids that are important for cell metabolism and function. Of note, high maternal dietary protein intake can also result in intra-uterine growth restriction and embryonic death, due to amino acid excesses, as well as the toxicity of ammonia, homocysteine, and H2 S that are generated from amino acid catabolism...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29466759/developmental-analysis-of-bone-marrow-neutrophils-reveals-populations-specialized-in-expansion-trafficking-and-effector-functions
#11
Maximilien Evrard, Immanuel W H Kwok, Shu Zhen Chong, Karen W W Teng, Etienne Becht, Jinmiao Chen, Je Lin Sieow, Hweixian Leong Penny, Goh Chi Ching, Sapna Devi, José Maria Adrover, Jackson L Y Li, Ka Hang Liong, Leonard Tan, Zhiyong Poon, Shihui Foo, Jia Wang Chua, I-Hsin Su, Karl Balabanian, Françoise Bachelerie, Subhra K Biswas, Anis Larbi, William Y K Hwang, Vikas Madan, H Phillip Koeffler, Siew Cheng Wong, Evan W Newell, Andrés Hidalgo, Florent Ginhoux, Lai Guan Ng
Neutrophils are specialized innate cells that require constant replenishment from proliferative bone marrow (BM) precursors as a result of their short half-life. Although it is established that neutrophils are derived from the granulocyte-macrophage progenitor (GMP), the differentiation pathways from GMP to functional mature neutrophils are poorly defined. Using mass cytometry (CyTOF) and cell-cycle-based analysis, we identified three neutrophil subsets within the BM: a committed proliferative neutrophil precursor (preNeu) which differentiates into non-proliferating immature neutrophils and mature neutrophils...
February 20, 2018: Immunity
https://www.readbyqxmd.com/read/29463919/sex-dimorphic-acceleration-of-pericardial-subcutaneous-and-plasma-lipid-increase-in-offspring-of-poorly-nourished-baboons
#12
Anderson H Kuo, Cun Li, Vicki Mattern, Hillary F Huber, Anthony Comuzzie, Laura Cox, Matthias Schwab, Peter W Nathanielsz, Geoffrey D Clarke
Developmental programming by reduced maternal nutrition alters function in multiple offspring physiological systems, including lipid metabolism. We have shown that intrauterine growth restriction (IUGR) leads to offspring cardiovascular dysfunction with an accelerated aging phenotype in our nonhuman primate, baboon model. We hypothesized age-advanced pericardial fat and blood lipid changes. In pregnancy and lactation, pregnant baboons ate ad lib (control) or 70% ad lib diet (IUGR). We studied baboon offspring pericardial lipid deposition with magnetic resonance imaging at 5-6 years (human equivalent 20-24 years), skinfold thickness, and serum lipid profile at 8-9 years (human equivalent 32-36 years), comparing values with a normative life-course baboon cohort, 4-23 years...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29463326/functional-characteristics-of-chemosensory-proteins-in-the-sawyer-beetle-monochamus-alternatus-hope
#13
S Ali, M Z Ahmed, N Li, S A I Ali, M-Q Wang
The Japanese pine sawyer, Monochamus alternatus Hope (Coleoptera: Cerambycidae), is a major pest of pines and it is also the key vector of the exotic pinewood nematode in China. In the present study, we cloned, expressed, and purified a chemosensory protein (CSP) in M. alternatus. We surveyed its expression in various developmental stages of male and female adult tissues and determined its binding affinities for different pine volatiles using a competitive binding fluorescence assay. A CSP known as CSP5 in M...
February 21, 2018: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/29463135/investigating-a-theatre-based-intervention-for-indigenous-youth-with-fetal-alcohol-spectrum-disorder-exploration-d-une-intervention-bas%C3%A3-e-sur-le-th%C3%A3-%C3%A3-tre-aupr%C3%A3-s-de-jeunes-autochtones-atteints-du-syndrome-d-alcoolisme-f%C3%A5-tal
#14
Michelle Keightley, Sabrina Agnihotri, Sivaniya Subramaniapillai, Julia Gray, Jennifer Keresztesi, Angela Colantonio, Helene J Polatajko, Debra Cameron, Catherine Wiseman-Hakes
BACKGROUND: Theatre-based interventions use artistic media to facilitate social and emotional awareness and have therapeutic benefits for persons with developmental disabilities and mental health problems. The role of these interventions with Indigenous youth who have emotional, behavioural, and cognitive sequelae related to fetal alcohol spectrum disorder (FASD) has not been explored. PURPOSE: The purpose of this study was to explore the experiences and acceptability of a theatre-based approach for facilitating social communication and engagement in youth with FASD...
January 1, 2018: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/29461868/genome-wide-identification-characterization-and-transcriptional-analysis-of-the-metacaspase-gene-family-in-cucumber-cucumis-sativus
#15
Yong Zhou, Lifang Hu, Lunwei Jiang, Shiqiang Liu
Metacaspase (MC), a family of caspase-like proteins, plays vital roles in regulating programmed cell death (PCD) during development and in response to stresses in plants. In this study, five MC genes (designated as CsMC1 to CsMC5) were identified in the cucumber (Cucumis sativus) genome. Sequence analysis revealed that CsMC1-CsMC3 belong to type I MC proteins, while CsMC4 and CsMC5 are type II MC proteins. Phylogenetic tree and conserved motif analysis of MC proteins indicated that these proteins can be classified into two groups, which are correlated with the types of these MC proteins...
February 20, 2018: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29456083/placeholder-nucleosomes-underlie-germline-to-embryo-dna-methylation-reprogramming
#16
Patrick J Murphy, Shan Fu Wu, Cody R James, Candice L Wike, Bradley R Cairns
The fate and function of epigenetic marks during the germline-to-embryo transition is a key issue in developmental biology, with relevance to stem cell programming and transgenerational inheritance. In zebrafish, DNA methylation patterns are programmed in transcriptionally quiescent cleavage embryos; paternally inherited patterns are maintained, whereas maternal patterns are reprogrammed to match the paternal. Here, we provide the mechanism by demonstrating that "Placeholder" nucleosomes, containing histone H2A variant H2A...
February 9, 2018: Cell
https://www.readbyqxmd.com/read/29452576/assessing-retention-in-care-after-12-months-of-the-pediatric-development-clinic-implementation-in-rural-rwanda-a-retrospective-cohort-study
#17
Scheilla Bayitondere, Francois Biziyaremye, Catherine M Kirk, Hema Magge, Katrina Hann, Kim Wilson, Christine Mutaganzwa, Eric Ngabireyimana, Fulgence Nkikabahizi, Evelyne Shema, David B Tugizimana, Ann C Miller
BACKGROUND: In Africa, a high proportion of children are at risk for developmental delay. Early interventions are known to improve outcomes, but they are not routinely available. The Rwandan Ministry of Health with Partners In Health/Inshuti Mu Buzima created the Pediatric Development Clinic (PDC) model for providing interdisciplinary developmental care for high-risk infants in rural settings. As retention for chronic care has proven challenging in many settings, this study assesses factors related to retention to care after 12 months of clinic enrollment...
February 16, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29452352/conditional-ablation-and-conditional-rescue-models-for-casq2-elucidate-the-role-of-development-and-of-cell-type-specific-expression-of-casq2-in-the-cpvt2-phenotype
#18
Daniel J Flores, ThuyVy Duong, Luke O Brandenberger, Apratim Mitra, Aditya Shirali, John C Johnson, Danielle Springer, Audrey Noguchi, Zu-Xi Yu, Steven N Ebert, Andreas Ludwig, Bjorn C Knollmann, Mark D Levin, Karl Pfeifer
Cardiac calsequestrin (Casq2) associates with the Ryanodine Receptor 2 channel in the junctional sarcoplasmic reticulum to regulate Ca2+ release into the cytoplasm. Patients carrying mutations in CASQ2 display low resting heart rates under basal conditions and stress-induced polymorphic ventricular tachycardia (CPVT). In this study we generate and characterize novel conditional deletion and conditional rescue mouse models to test the influence of developmental programs on the heart rate and CPVT phenotypes...
February 14, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29451902/an-artificial-mirna-system-reveals-that-relative-contribution-of-translational-inhibition-to-mirna-mediated-regulation-depends-on-environmental-and-developmental-factors-in-arabidopsis-thaliana
#19
Patrick von Born, Marti Bernardo-Faura, Ignacio Rubio-Somoza
Development and fitness of any organism rely on properly controlled gene expression. This is especially true for plants, as their development is determined by both internal and external cues. MicroRNAs (miRNAs) are embedded in the genetic cascades that integrate and translate those cues into developmental programs. miRNAs negatively regulate their target genes mainly post-transcriptionally through two co-existing mechanisms; mRNA cleavage and translational inhibition. Despite our increasing knowledge about the genetic and biochemical processes involved in those concurrent mechanisms, little is known about their relative contributions to the overall miRNA-mediated regulation...
2018: PloS One
https://www.readbyqxmd.com/read/29451008/utilization-of-patient-navigators-in-an-urban-academic-pediatric-primary-care-practice
#20
Eli Sprecher, Kathleen Conroy, Jenny Chan, Paul R Lakin, Joanne Cox
Navigating health care systems can be a challenge for families. A retrospective descriptive cohort analysis was conducted assessing referrals to patient navigators (PNs) in one urban academic pediatric primary care practice. PNs tracked referral processes and a subset of PN referrals was assessed for markers of successful referrals. The most common reasons for referral were assistance overcoming barriers to care (46%), developmental concerns (38%), and adherence/care coordination concerns (14%). Significant predictors of referral were younger age, medical complexity, public insurance, male sex, and higher rates of no-show to visits in primary or subspecialist care...
February 1, 2018: Clinical Pediatrics
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