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https://www.readbyqxmd.com/read/27902959/kaempferol-a-phytoestrogen-suppressed-triclosan-induced-epithelial-mesenchymal-transition-and-metastatic-related-behaviors-of-mcf-7-breast-cancer-cells
#1
Geum-A Lee, Kyung-Chul Choi, Kyung-A Hwang
As a phytoestrogen, kaempferol is known to play a chemopreventive role inhibiting carcinogenesis and cancer progression. In this study, the influences of triclosan, an anti-bacterial agent recently known for an endocrine disrupting chemical (EDC), and kaempferol on breast cancer progression were examined by measuring their effects on epithelial-mesenchymal transition (EMT) and metastatic-related behaviors of MCF-7 breast cancer cells. Morphological changes of MCF-7 cells were observed, and a wound-healing assay was performed after the treatment of triclosan and kaempferol...
November 22, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27901295/nonparametric-de-noising-filter-optimization-using-structure-based-microscopic-image-classification
#2
Samsad Beagum, Nilanjan Dey, Amira S Ashour, Dimitra Sifaki-Pistolla, Valentina E Balas
The Local Polynomial Approximation (LPA) is a nonparametric filter that performs pixel-wise polynomial fit on a certain neighborhood. This filter can be supported by the Intersection of Confidence Interval rule (ICI) as an adaptation algorithm to identify the most suited neighborhood at which the polynomial assumptions provide superior fit for the observations. However, the LPA-ICI is considered to be a near-optimal de-noising filter. Moreover, the ICI rule has several parameters that affect its performance...
November 30, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27900363/integration-of-genomics-and-histology-revises-diagnosis-and-enables-effective-therapy-of-refractory-cancer-of-unknown-primary-with-pdl1-amplification
#3
Stefan Gröschel, Martin Bommer, Barbara Hutter, Jan Budczies, David Bonekamp, Christoph Heining, Peter Horak, Martina Fröhlich, Sebastian Uhrig, Daniel Hübschmann, Christina Geörg, Daniela Richter, Nicole Pfarr, Katrin Pfütze, Stephan Wolf, Peter Schirmacher, Dirk Jäger, Christof von Kalle, Benedikt Brors, Hanno Glimm, Wilko Weichert, Albrecht Stenzinger, Stefan Fröhling
Identification of the tissue of origin in cancer of unknown primary (CUP) poses a diagnostic challenge and is critical for directing site-specific therapy. Currently, clinical decision-making in patients with CUP primarily relies on histopathology and clinical features. Comprehensive molecular profiling has the potential to contribute to diagnostic categorization and, most importantly, guide CUP therapy through identification of actionable lesions. We here report the case of an advanced-stage malignancy initially mimicking poorly differentiated soft-tissue sarcoma that did not respond to multiagent chemotherapy...
November 2016: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/27898194/inflammatory-cell-induced-corrosion-in-total-knee-arthroplasty-a-retrieval-study
#4
Arianna Cerquiglini, Johann Henckel, Harry S Hothi, Anna Di Laura, John A Skinner, Alister J Hart
Metal release in patients with joint replacements is associated with local tissue reactions, pain, and ultimately revision of implants. One of the causes of this metal loss is speculated to be due to a mechanism of inflammatory cell-induced corrosion (ICIC). In this knee retrieval study, we aimed to: (1) identify the extent and location of ICI corrosion patterns on our femoral and tibial components and (2) correlate our findings with implant and clinical information. We investigated 28 femoral and 9 tibial components made of polished CoCr for presence of ICIC, using macroscopic and microscopic screening and statistical analyses to identify any significant correlations between our results and clinical information...
November 29, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27891636/effects-of-pulsed-radiofrequency-neuromodulation-on-the-rat-with-overactive-bladder
#5
En Jen, Tsung-Hsun Hsieh, Tsung-Che Lu, Meng-Chao Chen, Fu-Jung Lee, Chih-Ting Lin, Shih-Ching Chen, Pei-Yi Chu, Chih-Wei Peng, Chii-Wann Lin
AIM: To quantify the effects of pulsed radiofrequency (PRF) electrical stimulations of the pudendal and pelvic nerves on the bladder function of rats with detrusor overactivity. METHODS: All rats were pretreated with a continuous transvesical infusion of 0.5% acetic acid (AA) for inducing detrusor overactivity. Intravesical pressure was recorded using cysometrography (CMG) during the continuous transvesical infusion to examine the effects of PRF electrical stimulation of the pudendal and pelvic nerves individually...
November 28, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27891180/the-effect-of-foot-orthoses-with-forefoot-cushioning-or-metatarsal-pad-on-forefoot-peak-plantar-pressure-in-running
#6
Michaela Hähni, Anja Hirschmüller, Heiner Baur
BACKGROUND: Foot orthoses are frequently used in sports for the treatment of overuse complaints with sufficient evidence available for certain foot-related overuse pathologies like plantar fasciitis, rheumatoid arthritis and foot pain (e.g., metatarsalgia). One important aim is to reduce plantar pressure under prominent areas like metatarsal heads. For the forefoot region, mainly two common strategies exist: metatarsal pad (MP) and forefoot cushioning (FC). The aim of this study was to evaluate which of these orthosis concepts is superior in reducing plantar pressure in the forefoot during running...
2016: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/27890174/immune-related-adverse-effects-of-cancer-immunotherapy-implications-for-rheumatology
#7
REVIEW
Laura C Cappelli, Ami A Shah, Clifton O Bingham
Immune checkpoint inhibitors (ICIs) are increasingly studied and used as therapy for a growing number of malignancies. ICIs work by blocking inhibitory pathways of T-cell activation, leading to an immune response directed against tumors. Such nonspecific immunologic activation can lead to immune-related adverse events (IRAEs). Some IRAEs, including inflammatory arthritis, sicca syndrome, myositis, and vasculitis, are of special interest to rheumatologists. As use of ICIs increases, recognition of these IRAEs and developing treatment strategies will become important...
February 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27882710/john-porter-book-prize-lecture-bringing-the-social-back-in-on-the-integration-of-muslim-immigrants-and-the-jurisprudence-of-muslim-minorities
#8
Abdolmohammad Kazemipur
In much of the academic debate on the integration of Muslims into Western liberal democracies, Islam is often treated as one or the sole independent variable in the lives of Muslims. Offering to view Islam-or the understanding of Islam among Muslims-as the dependent variable, The Muslim Question in Canada discusses the influence of socioeconomic forces in shaping the Muslim immigrants' opinions, modes of thinking, and even interpretations of their faith. Drawing on this general approach, which is introduced and developed in the book using a variety of both quantitative and qualitative data, this article focuses on a school of thought within the Islamic jurisprudence known as fiqh al-aqalliyyat al-Muslema (the jurisprudence of Muslim minorities)...
November 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/27871959/intracavernous-injections-in-spinal-cord-injured-men-with-erectile-dysfunction-a-systematic-review-and-meta-analysis
#9
REVIEW
Lucie Chochina, Florian Naudet, Clément Chéhensse, Andrea Manunta, Mireille Damphousse, Isabelle Bonan, François Giuliano
INTRODUCTION: Despite improvements in the care of patients after spinal cord injury (SCI), permanent impairment of locomotion, sensation, and autonomic function remains a major hurdle. After the acute stage of injury, recovering sexual function is a high priority. AIM: To review the efficacy of intracavernous injections (ICIs) in men with SCI and to identify prognostic factors affecting the efficacy of ICIs in this population. METHODS: Systematic review of the literature was conducted using the PubMed-Medline, Embase, EBSCO, Web of Science, and Cochrane Library databases...
July 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27858578/severe-cerebral-edema-following-nivolumab-treatment-for-pediatric-glioblastoma-case-report
#10
Xiao Zhu, Michael M McDowell, William C Newman, Gary E Mason, Stephanie Greene, Mandeep S Tamber
Nivolumab is an immune checkpoint inhibitor (ICI) currently undergoing Phase III clinical trials for the treatment of glioblastoma. The authors present the case of a 10-year-old girl with glioblastoma treated with nivolumab under compassionate-use guidelines. After the first dose of nivolumab the patient developed hemiparesis, cerebral edema, and significant midline shift due to severe tumor necrosis. She was managed using intravenous dexamethasone and discharged on a dexamethasone taper. The patient's condition rapidly deteriorated after the second dose of nivolumab, demonstrating hemiplegia, seizures, and eventually unresponsiveness with a fixed and dilated left pupil...
November 18, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27849015/sterile-inflammation-as-a-factor-in-human-male-infertility-involvement-of-toll-like-receptor-2-biglycan-and-peritubular-cells
#11
C Mayer, M Adam, L Glashauser, K Dietrich, J U Schwarzer, F-M Köhn, L Strauss, H Welter, M Poutanen, A Mayerhofer
Changes in the wall of seminiferous tubules in men with impaired spermatogenesis imply sterile inflammation of the testis. We tested the hypothesis that the cells forming the wall of seminiferous tubules, human testicular peritubular cells (HTPCs), orchestrate inflammatory events and that Toll like receptors (TLRs) and danger signals from the extracellular matrix (ECM) of this wall are involved. In cultured HTPCs we detected TLRs, including TLR2. A TLR-2 ligand (PAM) augmented interleukin 6 (IL-6), monocyte chemo-attractant protein-1 (MCP-1) and pentraxin 3 (PTX3) in HTPCs...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27848165/immune-related-adverse-events-associated-with-immune-checkpoint-inhibitors
#12
REVIEW
Daphne Day, Aaron R Hansen
Immune checkpoint inhibitors (ICIs), including antibodies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein-1 (PD-1), have shown durable treatment responses in multiple tumor types by enhancing antitumor immunity. However, removal of self-tolerance can induce autoimmunity and produce a unique immune-driven toxicity profile, termed immune-related adverse events (irAEs). As ICIs gain approval for a growing number of indications, it is imperative clinicians increase their knowledge of and ability to manage irAEs...
November 15, 2016: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/27845303/new-insights-into-estrogenic-regulation-of-o-6-methylguanine-dna-methyltransferase-mgmt-in-human-breast-cancer-cells-co-degradation-of-er-%C3%AE-and-mgmt-proteins-by-fulvestrant-or-o-6-benzylguanine-indicates-fresh-avenues-for-therapy
#13
Ameya Paranjpe, Nathan I Bailey, Santhi Konduri, George C Bobustuc, Francis Ali-Osman, Mohd A Yusuf, Surendra R Punganuru, Hanumantha Rao Madala, Debasish Basak, Agm Mostofa, Kalkunte S Srivenugopal
Endocrine therapy using estrogen receptor-α (ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers. To exploit any DNA repair deficiencies associated with endocrine therapy, we investigated the functional and physical interactions of ER-α with O(6)-methylguanine DNA methyltransferase (MGMT), a unique DNA repair protein that confers tumor resistance to various anticancer alkylating agents. The ER-α -positive breast cancer cell lines (MCF-7, T47D) and ER- negative cell lines (MDAMB-468, MDAMB-231), and established inhibitors of ER-α and MGMT, namely, ICI-182,780 (Faslodex) and O(6)-benzylguanine, respectively, were used to study MGMT- ER interactions...
September 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27834713/draft-genome-sequence-of-corynebacterium-amycolatum-strain-icis-53-isolated-from-a-female-urogenital-tract
#14
Irina V Gladysheva, Sergey V Cherkasov, Yuriy A Khlopko, Andrey O Plotnikov, Natalya E Gogoleva
This report describes the draft genome sequence of Corynebacterium amycolatum strain ICIS 53, isolated from the reproductive tract of a healthy woman. The size of the genome was 2,460,257 bp (58.98% G+C content). Annotation revealed 2,173 coding sequences, including 2,076 proteins, 7 rRNA genes, and 53 tRNA genes.
November 10, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27832943/evaluation-of-the-anti-inflammatory-effects-of-%C3%AE-adrenoceptor-agonists-on-human-lung-macrophages
#15
Sharonjit K Gill, Helen M Marriott, S Kim Suvarna, Peter T Peachell
The principal mechanism by which bronchodilator β-adrenoceptor agonists act is to relax airways smooth muscle although they may also be anti-inflammatory. However, the extent of anti-inflammatory activity and the cell types affected by these agonists are uncertain. The purpose of this study was to evaluate whether β-adrenoceptor agonists prevent pro-inflammatory cytokine generation from activated human lung macrophages. Macrophages were isolated and purified from human lung. The cells were pre-treated with both short-acting (isoprenaline, salbutamol, terbutaline) and long-acting (formoterol, salmeterol, indacaterol) β-agonists before activation with lipopolysaccharide (LPS) to induce cytokine (TNFα, IL-6, IL-8 and IL-10) generation...
November 7, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27832664/acute-interstitial-nephritis-related-to-immune-checkpoint-inhibitors
#16
Julie Belliere, Nicolas Meyer, Julien Mazieres, Sylvie Ollier, Serge Boulinguez, Audrey Delas, David Ribes, Stanislas Faguer
BACKGROUND: Immune checkpoint inhibitors (anti-PD1 or anti-CTLA-4) are increasingly used in various cancers. Immune checkpoint inhibitors (ICI)-related renal disorders are poorly described (9 cases) and were only related to Ipilimumab. METHODS: Retrospective collection of clinical charts of all the patients admitted for renal disorders following ICI in the University Hospital of Toulouse (France). RESULTS: We report on adverse renal events that occurred in three patients treated with anti-PD1 (nivolumab or pembrolizumab) or anti-CTLA-4 (ipilimumab)...
November 10, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27828307/nyquist-pulse-shaping-using-arrayed-waveguide-grating-routers
#17
Yiwei Xie, Leimeng Zhuang, Chen Zhu, Arthur James Lowery
We propose and demonstrate by simulations a novel Nyquist-WDM (N-WDM) superchannel transmitter based on an arrayed waveguide grating router (AWGR). This approach can generate Nyquist pulses at multiple wavelengths using a single AWGR. Results for a 3-channel 960-Gbit/s QPSK superchannel system show that a 10% guard band reduces the inter-channel interference (ICI) sufficiently. The design introduces less than 0.16-dB penalty when the waveguide loss is 2 dB/cm and 0.73-dB penalty when the standard deviation of phase error is 10°...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27818313/erythropoietin-in-the-locus-coeruleus-attenuates-the-ventilatory-response-to-co2-in-rats
#18
Carlos A Silva, Mariane C Vicente, Luana Tenorio-Lopes, Jorge Soliz, Luciane H Gargaglioni
The Locus coeruleus (LC) is a pontine area that contributes to the CO2/pH chemosensitivity. LC cells express erythropoietin (Epo) receptors (EpoR), and Epo in the brainstem is a potent normoxic and hypoxic respiratory stimulant. However, a recent study showed that the intra-cisternal injection (ICI) of Epo antagonist does not alter the hypercapnic ventilatory response in mice. As ICI leads to a widespread dispersal of the product throughout the brainstem, in this work we evaluated the specific impact of Epo in the LC-mediated ventilatory response to CO2 (by whole body plethysmography) in juvenile male Wistar rats...
November 3, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27809739/management-of-adverse-events-related-to-new-cancer-immunotherapy-immune-checkpoint-inhibitors
#19
Jack M Bourke, Michael O'Sullivan, Muhammad A Khattak
New immunotherapies have significantly improved survival in certain advanced cancers in recent years, particularly metastatic melanoma and lung cancer. The most effective of these therapies are the immune checkpoint inhibitors (ICIs) such as ipilimumab, nivolumab and pembrolizumab. The use of ICIs will continue to increase in the coming years as evidence of their benefit in a range of other cancers builds. ICIs are associated with novel immune-related adverse events (irAEs), which can involve a wide range of organs...
November 7, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27806346/cross-talk-between-microbiota-and-immune-fitness-to-steer-and-control-response-to-anti-pd-1-pdl-1-treatment
#20
REVIEW
Andrea Botticelli, Ilaria Zizzari, Federica Mazzuca, Paolo Antonio Ascierto, Lorenza Putignani, Luca Marchetti, Chiara Napoletano, Marianna Nuti, Paolo Marchetti
Immune Checkpoint Inhibitors (ICIs) are improving the survival of cancer patients, however only the 20-30% of treated patients present clinical benefits. Toxicity represents the major cause of reduced dosage, delayed drug administration and therapy discontinuation. Hence in the context of multiple treatment possibilities, the identification of predictive markers of response and toxicity is a challenging approach for drug selection in order to obtain the best clinical benefit while minimizing the side effects...
October 28, 2016: Oncotarget
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