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https://www.readbyqxmd.com/read/29027434/-protective-effect-of-notoginsenoside-r1-on-neuron-injury-induced-by-ogd-r-through-atf6-akt-signaling-pathway
#1
Qian-Ling Hou, Yan Wang, Ying-Bo Li, Xue-Lian Hu, Sha-Li Wang
Notoginsenoside R1(NGR1),a critical compound in traditional herb Panax notoginseng, is a kind of estrogen receptor agonist.It is reported to exhibit anti-apoptotic,anti-oxidative and anti-inflammatory properties activity, so it is widely used for treatment of various diseases.In order to investigate the potential neuroprotective effect of NGR1 in hypoxic-ischemic brain damage(HIBD), primary cortical neurons were used in this study to establish oxygen-glucose deprivation/reoxygenation(OGD/R) injury models. They were treated with NGR1 and estrogen receptor inhibitor ICI-182780 respectively, then the neuronal survival, cell membrane integrity and apoptosis were assessed by MTT assay,lactate dehydrogenase test(LDH) and Hoechst 33342 stain respectively, while the protein expression levels of ATF6α,p-Akt,Akt,Bax and Cleaved Caspase-3 were measured by Western blotting...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29025772/impaired-hla-class-i-antigen-processing-and-presentation-as-a-mechanism-of-acquired-resistance-to-immune-checkpoint-inhibitors-in-lung-cancer
#2
Scott Gettinger, Jungmin Choi, Katherine Hastings, Anna Truini, Ila Datar, Ryan Sowell, Anna Wurtz, Weilai Dong, Guoping Cai, Mary Ann Melnick, Victor Y Du, Joseph Schlessinger, Sarah B Goldberg, Anne Chiang, Miguel F Sanmamed, Ignacio Melero, Jackeline Agorreta, Luis M Montuenga, Richard Lifton, Soldano Ferrone, Paula Kavathas, David L Rimm, Susan M Kaech, Kurt A Schalper, Roy S Herbst, Katerina Politi
Mechanisms of acquired resistance to immune checkpoint inhibitors (ICIs) are poorly understood. We leveraged a collection of 14 ICI-resistant lung cancer samples to investigate whether alterations in genes encoding HLA Class I antigen processing and presentation machinery (APM) components or interferon signaling play a role in acquired resistance to PD-1 or PD-L1 antagonistic antibodies. Recurrent mutations or copy number changes were not detected in our cohort. In one case, we found acquired homozygous loss of B2M that caused lack of cell surface HLA class I expression in the tumor and a matched patient-derived xenograft (PDX)...
October 12, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29016128/acute-toxicity-teratogenic-and-estrogenic-effects-of-bisphenol-a-and-its-alternative-replacements-bisphenol-s-bisphenol-f-and-bisphenol-af-in-zebrafish-embryo-larvae
#3
John Moreman, Okhyun Lee, Maciej Trznadel, Arthur David, Tetsuhiro Kudoh, Charles R Tyler
Bisphenol A (BPA), a chemical incorporated into plastics and resins, has estrogenic activity and is associated with adverse health effects in humans and wildlife. Similarly-structured BPA analogues are widely used but far less is known about their potential toxicity or estrogenic activity in vivo. We undertook the first comprehensive analysis on the toxicity and teratogenic effects of the bisphenols BPA, BPS, BPF and BPAF in zebrafish embryo-larvae and an assessment on their estrogenic mechanisms in an estrogen-responsive transgenic fish Tg(ERE:Gal4ff)(UAS:GFP)...
October 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28985473/red-clover-aryl-hydrocarbon-receptor-ahr-and-estrogen-receptor-er-agonists-enhance-genotoxic-estrogen-metabolism
#4
Tareisha L Dunlap, Caitlin E Howell, Nita Mukand, Shao-Nong Chen, Guido F Pauli, Birgit Maria Dietz, Judy L Bolton
Many women consider botanical dietary supplements (BDSs) as safe alternatives to hormone therapy for menopausal symptoms. However, the effect of BDSs on breast cancer risk is largely unknown. In the estrogen chemical carcinogenesis pathway, P450 1B1 metabolizes estrogens to 4-hydroxylated catechols, which are oxidized to genotoxic quinones that initiate and promote breast cancer. In contrast, P450 1A1 catalyzed 2-hydroxylation represents a detoxification pathway. The current study evaluated the effects of red clover, a popular BDS used for women's health, and its isoflavones, biochanin A (BA), formononetin (FN), genistein (GN), and daidzein (DZ), on estrogen metabolism...
October 6, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28983973/granuloma-annulare-associated-with-immune-checkpoint-inhibitors
#5
J Wu, B Y Kwong, K J Martires, K E Rieger, W H Chung, G V Iyer, M E Lacouture
Recent developments in cancer immunology have ushered in immunotherapy as a new era in anti-cancer therapy. The cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell death receptor-1(PD-1)/ PD ligand-1 (PD-L1) signaling pathway are immune checkpoints of tumour-induced immunosuppression. Immune checkpoint inhibitors (ICIs) activate cytotoxic T cells to attack tumour cells, leading to durable antitumour responses. By unbalancing the immune system, ICIs may induce autoimmunity that results in organ dysfunction, referred to as immune-related adverse events (irAEs)...
October 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28973656/incidence-of-endocrine-dysfunction-following-the-use-of-different-immune-checkpoint-inhibitor-regimens-a-systematic-review-and-meta-analysis
#6
Romualdo Barroso-Sousa, William T Barry, Ana C Garrido-Castro, F Stephen Hodi, Le Min, Ian E Krop, Sara M Tolaney
Importance: If not promptly recognized, endocrine dysfunction can be life threatening. The incidence and risk of developing such adverse events (AEs) following the use of immune checkpoint inhibitor (ICI) regimens are unknown. Objective: To compare the incidence and risk of endocrine AEs following treatment with US Food and Drug Administration-approved ICI regimens. Data Sources: A PubMed search through July 18, 2016, using the following keywords was performed: "ipilimumab," "MDX-010," "nivolumab," "BMS-963558," "pembrolizumab," "MK-3475," "atezolizumab," "MPDL3280A," and "phase...
September 28, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28971605/17%C3%AE-estradiol-reduces-cav-1-2-channel-abundance-and-attenuates-ca-2-dependent-contractions-in-coronary-arteries
#7
Brent J F Hill, Robin J Dalton, Biny K Joseph, Keshari M Thakali, Nancy J Rusch
One mechanism by which the female sex may protect against elevated coronary vascular tone is inhibition of Ca(2+) entry into arterial smooth muscle cells (ASMCs). In vitro findings confirm that high estrogen concentrations directly inhibit voltage-dependent Cav 1.2 channels in coronary ASMCs. For this study, we hypothesized that the nonacute, in vitro exposure of coronary arteries to a low concentration of 17β-estradiol (17βE) reduces the expression of Cav 1.2 channel proteins in coronary ASMCs. Segments of the right coronary artery obtained from sexually mature female pigs were mounted for isometric tension recording...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28958969/nocardiose-cutan%C3%A3-e-chez-une-patiente-immunocomp%C3%A3-tente-a-propos-d-un-cas-et-revue-de-la-litt%C3%A3-rature
#8
Alexandre Tang, Anaëlle Muggeo, Boris Rihn, Marie Catherine Thiercelin, Lucien Brasme, Christophe de Champs, Thomas Guillard
Nocardia spp. est responsable d'infections opportunistes chez les patients immunodéprimés, principalement d'infections pulmonaires. Le système nerveux central est la localisation extra-pulmonaire la plus souvent retrouvée. Nous rapportons ici un cas d'infection cutanée à N. brasiliensis chez une patiente immunocompétente, ainsi qu'une revue de la littérature.
October 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28956259/checkpoint-inhibitors-applications-for-autoimmunity
#9
REVIEW
Anna S Tocheva, Adam Mor
To limit excessive T cell-mediated inflammatory responses, the immune system has a milieu of inhibitory receptors, called immune checkpoints. Cancer cells have evolved to seize those inhibitory pathways and to prevent T cell-mediated killing of tumor cells. Therefore, immune checkpoint inhibitors (ICI) consisting of blocking antibodies against these receptors present an exciting avenue in the fight against cancer. The last decade has seen the implementation of ICI against a variety of cancer indications that have improved the overall anti-tumor responses and patient survival...
September 27, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28955226/tamoxifen-from-failed-contraceptive-pill-to-best-selling-breast-cancer-medicine-a-case-study-in-pharmaceutical-innovation
#10
Viviane M Quirke
Today, tamoxifen is one of the world's best-selling hormonal breast cancer drugs. However, it was not always so. Compound ICI 46,474 (as it was first known) was synthesized in 1962 within a project to develop a contraceptive pill in the pharmaceutical laboratories of ICI (now part of AstraZeneca). Although designed to act as an anti-estrogen, the compound stimulated, rather than suppressed ovulation in women. This, and the fact that it could not be patented in the USA, its largest potential market, meant that ICI nearly stopped the project...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28950287/predicting-response-and-toxicity-to-immune-checkpoint-inhibitors-using-routinely-available-blood-and-clinical-markers
#11
REVIEW
Ashley M Hopkins, Andrew Rowland, Ganessan Kichenadasse, Michael D Wiese, Howard Gurney, Ross A McKinnon, Chris S Karapetis, Michael J Sorich
Immune checkpoint inhibitors (ICI) are an important development in the treatment of advanced cancer. A substantial proportion of patients treated with ICI do not respond, and additionally patients discontinue treatment due to adverse effects. While many novel biological markers related to the specific mechanisms of ICI actions have been investigated, there has also been considerable research to identify routinely available blood and clinical markers that may predict response to ICI therapy. If validated, these markers have the advantage of being easily integrated into clinical use for nominal expense...
September 26, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28943093/natural-killer-cell-immunotherapies-against-cancer-checkpoint-inhibitors-and-more
#12
REVIEW
Laura Chiossone, Margaux Vienne, Yann M Kerdiles, Eric Vivier
After many years of research, recent advances have shed new light on the role of the immune system in advanced-stage cancer. Various types of immune cells may be useful for therapeutic purposes, along with chemical molecules and engineered monoclonal antibodies. The immune effectors suitable for manipulation for adoptive transfer or drug targeting in vivo include natural killer (NK) cells. These cells are of particular interest because they are tightly regulated by an array of inhibitory and activating receptors, enabling them to kill tumor cells while sparing normal cells...
September 22, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28938341/neurological-toxicities-associated-with-immune-checkpoint-inhibitors
#13
Mehdi Touat, Daniel Talmasov, Damien Ricard, Dimitri Psimaras
PURPOSE OF REVIEW: Immune-checkpoint inhibitors (ICIs) constitute a novel class of agents recently approved to treat a number of human malignancies. Due to their immunomodulatory mechanism of action, ICIs can generate a wide range of immune-related adverse events (irAEs) of which neurological toxicities are of special interest because of their potential severity. The objective of this review is to examine the recent literature describing neurological irAEs and discuss their optimal management...
September 21, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28934800/comparison-of-intraarticular-pulsed-radiofrequency-and-intraarticular-corticosteroid-injection-for-management-of-cervical-facet-joint-pain
#14
Ji Woon Lim, Yun-Woo Cho, Dong Gyu Lee, Min Cheol Chang
BACKGROUND: Disorders of the facet joints are some of the most common sources of chronic spinal pain. Facet joint pain is responsible for approximately 50% of patients with chronic neck pain. Pulsed radiofrequency (PRF) stimulation, after placing needle electrodes into the joint space, has been recently reported for the management of joint pain. OBJECTIVE: The aim of this study was to evaluate the effect of intraarticular (IA) PRF for the management of cervical facet joint (CFJ) pain...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934595/copd-alters-immune-cell-composition-and-immune-checkpoint-inhibitor-efficacy-in-nsclc
#15
Nicholas M Mark, Julia Kargl, Stephanie E Busch, Grace H Y Yang, Heather E Metz, Huajia Zhang, Jesse J Hubbard, Sudhakar N J Pipavath, David K Madtes, A McGarry Houghton
RATIONALE: Chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) are interrelated diseases with substantial mortality; the pathogenesis of both involves aberrant immune functioning. OBJECTIVE: To profile the immune cell composition and function in patients with NSCLC and describe the effect of COPD on lung and tumor microenvironments. METHODS: We profiled resected lung and tumor tissue using flow cytometry and T-cell receptor sequencing in patients with and without COPD from a prospective cohort of patients undergoing resection of NSCLC...
September 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28923066/data-integration-from-pathology-slides-for-quantitative-imaging-of-multiple-cell-types-within-the-tumor-immune-cell-infiltrate
#16
Zhaoxuan Ma, Stephen L Shiao, Emi J Yoshida, Steven Swartwood, Fangjin Huang, Michael E Doche, Alice P Chung, Beatrice S Knudsen, Arkadiusz Gertych
BACKGROUND: Immune cell infiltrates (ICI) of tumors are scored by pathologists around tumor glands. To obtain a better understanding of the immune infiltrate, individual immune cell types, their activation states and location relative to tumor cells need to be determined. This process requires precise identification of the tumor area and enumeration of immune cell subtypes separately in the stroma and inside tumor nests. Such measurements can be accomplished by a multiplex format using immunohistochemistry (IHC)...
September 18, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28917596/response-rate-to-chemotherapy-after-immune-checkpoint-inhibition-in-metastatic-urothelial-cancer
#17
Bernadett Szabados, Nick van Dijk, Yen Zhi Tang, Michiel S van der Heijden, Akhila Wimalasingham, Alfonso Gomez de Liano, Simon Chowdhury, Simon Hughes, Sarah Rudman, Mark Linch, Thomas Powles
Immune checkpoint inhibitors (ICIs) are active in metastatic urothelial carcinoma (MUC). They have joined chemotherapy (CT) as a standard of care. Here, we investigate the activity of CT after progression on ICIs. Two cohorts of sequential patients with MUC were described (n=28). Cohort A received first-line ICIs followed by CT after progression. Cohort B received CT after failure of first-line platinum-based CT followed by ICIs. Response rate (RR) to CT was assessed using Response Evaluation Criteria in Solid Tumors (RECIST v1...
September 13, 2017: European Urology
https://www.readbyqxmd.com/read/28917578/emerging-biomarkers-for-cancer-immunotherapy-in-melanoma
#18
REVIEW
Margaret L Axelrod, Douglas B Johnson, Justin M Balko
The treatment and prognosis of metastatic melanoma has changed substantially since the advent of novel immune checkpoint inhibitors (ICI), agents that enhance the anti-tumor immune response. Despite the success of these agents, clinically actionable biomarkers to aid patient and regimen selection are lacking. Herein, we summarize and review the evidence for candidate biomarkers of response to ICIs in melanoma. Many of these candidates can be examined as parts of a known molecular pathway of immune response, while others are clinical in nature...
September 14, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28913619/bile-duct-obstruction-in-a-patient-treated-with-nivolumab-as-second-line-chemotherapy-for-advanced-non-small-cell-lung-cancer-a-case-report
#19
Jumpei Kashima, Yusuke Okuma, Ryoko Shimizuguchi, Kazuro Chiba
Immune checkpoint inhibitors (ICIs) are becoming a standard therapy for non-small-cell lung cancer in the advanced stage. As these ICIs become widely available in clinical practice, immune-related adverse effects will become more common. Here we report a patient with lung adenocarcinoma who was treated with nivolumab and developed obstruction because of biliary inflammation. A 63-year-old Japanese man having lung adenocarcinoma with pleural dissemination complained of epigastric pain on the fifth cycle of nivolumab...
September 14, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28912325/draft-genome-sequence-of-the-vaginal-isolate-corynebacterium-amycolatum-icis-9
#20
Irina V Gladysheva, Yuriy A Khlopko, Sergey V Cherkasov
Corynebacterium amycolatum ICIS 9 was isolated from a vaginal smear of a healthy woman. Here, we report the draft genome sequence of C. amycolatum ICIS 9, which will be useful for further studies of specific genetic features of this strain and for understanding its probiotic properties.
September 14, 2017: Genome Announcements
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