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Dirk De Ridder

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https://www.readbyqxmd.com/read/29084160/new-instrument-to-measure-hospital-patient-experiences-in-flanders
#1
Luk Bruyneel, Else Tambuyzer, Ellen Coeckelberghs, Dirk De Wachter, Walter Sermeus, Dirk De Ridder, Dirk Ramaekers, Ilse Weeghmans, Kris Vanhaecht
Implementing a standardized patient experience survey may initiate a process to apply pressure on hospitals to attend to improving patient experiences. In Flanders, Belgium, the Flemish Patient Survey was developed between 2011 and 2015. A preliminary version was developed from a scoping review and patient and expert focus groups, and included 27 items for eight hypothesized dimensions: 'preparing for hospital stay', 'information and communication', 'coordination', 'respect', 'privacy', 'safe care', pain management', and 'participation'...
October 30, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29079475/high-definition-transcranial-pink-noise-stimulation-of-anterior-cingulate-cortex-on-food-craving-an-explorative-study
#2
Sook Ling Leong, Dirk De Ridder, Sven Vanneste, Wayne Sutherland, Samantha Ross, Patrick Manning
Dysfunctional neural activity in the cortical reward system network has been implicated in food addiction. This is the first study exploring the potential therapeutic effects of high definition transcranial pink noise stimulation (HD-tPNS) targeted at the anterior cingulate cortex (ACC) on craving and brain activity in women with obesity who showed features of food addiction (Yale Food Addiction Scale score of ≥3). Sixteen eligible females participated in a randomized, double-blind, parallel group study. Participants received six 20-minute sessions of either 1 mA (n = 8) or sham (n = 8) stimulation with HD-tPNS over two weeks...
January 1, 2018: Appetite
https://www.readbyqxmd.com/read/29032188/genito-urinary-genomics-and-emerging-biomarkers-for-immunomodulatory-cancer-treatment
#3
REVIEW
Thomas Gevaert, Rodolfo Montironi, Antonio Lopez-Beltran, Geert Van Leenders, Yves Allory, Dirk De Ridder, Frank Claessens, Mark Kockx, Murat Akand, Steven Joniau, George Netto, Louis Libbrecht
Immunotherapy is gradually becoming a key factor in the therapeutic algorithm for patients with genito-urinary (GU) cancers at different stages of disease. Robust and reliable biomarkers are crucial for an appropriate inclusion of patients in clinical trials and for a reliable patient selection for treatments with immunomodulatory drugs. The increasing knowledge on the genomic landscape of GU cancers supports stratification of patients for targeted therapies. This review focusses on emerging biomarkers and the role of genomics in predicting clinical benefit to immunomodulatory agents in GU cancers...
October 12, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28992962/the-long-and-short-term-variability-of-breathing-induced-tumor-motion-in-lung-and-liver-over-the-course-of-a-radiotherapy-treatment
#4
Jennifer Dhont, Jef Vandemeulebroucke, Manuela Burghelea, Kenneth Poels, Tom Depuydt, Robbe Van Den Begin, Cyril Jaudet, Christine Collen, Benedikt Engels, Truus Reynders, Marlies Boussaer, Thierry Gevaert, Mark De Ridder, Dirk Verellen
PURPOSE: To evaluate the short and long-term variability of breathing induced tumor motion. MATERIALS AND METHODS: 3D tumor motion of 19 lung and 18 liver lesions captured over the course of an SBRT treatment were evaluated and compared to the motion on 4D-CT. An implanted fiducial could be used for unambiguous motion information. Fast orthogonal fluoroscopy (FF) sequences, included in the treatment workflow, were used to evaluate motion during treatment. Several motion parameters were compared between different FF sequences from the same fraction to evaluate the intrafraction variability...
October 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28963588/comparative-study-of-the-organisation-and-phenotypes-of-bladder-interstitial-cells-in-human-mouse-and-rat
#5
Thomas Gevaert, Jochen Neuhaus, Els Vanstreels, Dirk Daelemans, Wouter Everaerts, Frank Van Der Aa, Jean-Pierre Timmermans, Tania Roskams, Clara Steiner, Isabel Pintelon, Dirk De Ridder
With most research on interstitial cells (IC) in the bladder being conducted on animal models, it remains unclear whether all structural and functional data on IC from animal models can be translated to the human context. This prompted us to compare the structural and immunohistochemical properties of IC in bladders from mouse, rat and human. Tissue samples were obtained from the bladder dome and subsequently processed for immunohistochemistry and electron microscopy. The ultrastructural properties of IC were compared by means of electron microscopy and IC were additionally characterized with single/double immunohistochemistry/immunofluorescence...
September 30, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28877142/adding-prefrontal-transcranial-direct-current-stimulation-before-occipital-nerve-stimulation-in-fibromyalgia
#6
Hye Bin Yoo, Jan Ost, Wim Joos, Tony Van Havenbergh, Dirk De Ridder, Sven Vanneste
OBJECTIVES: Fibromyalgia is a type of chronic musculoskeletal pain without a clear peripheral origin of nociception, often associated with depression. The underlying pathophysiology involves changes in a functional network that is related to pain and emotional processing in the central nervous system. Transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex or the occipital nerve (ON) are non-invasive neuromodulation techniques capable of improving fibromyalgia symptoms...
September 1, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28723383/clinical-case-discussion-repeat-sling-surgery-should-we-offer-a-second-sling
#7
Femke Vandercruysse, Dirk De Ridder, Frank Van der Aa
Advantages of secondary sling surgery for persistent or recurrent stress urinary incontinence include low complexity and short operation time, low blood loss, and short hospitalization. Rates of perioperative complications, erosion, and postoperative voiding difficulties are comparable with primary sling surgery. The presence of urethral (hyper)mobility after primary midurethral sling seems to be an important factor affecting success rates of repeat sling surgery.
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28650974/resting-state-electrical-brain-activity-and-connectivity-in-fibromyalgia
#8
Sven Vanneste, Jan Ost, Tony Van Havenbergh, Dirk De Ridder
The exact mechanism underlying fibromyalgia is unknown, but increased facilitatory modulation and/or dysfunctional descending inhibitory pathway activity are posited as possible mechanisms contributing to sensitization of the central nervous system. The primary goal of this study is to identify a fibromyalgia neural circuit that can account for these abnormalities in central pain. The second goal is to gain a better understanding of the functional connectivity between the default and the executive attention network (salience network plus dorsal lateral prefrontal cortex) in fibromyalgia...
2017: PloS One
https://www.readbyqxmd.com/read/28598859/the-role-of-the-dorsal-anterior-cingulate-cortex-dacc-in-a-cognitive-and-emotional-counting-stroop-task-two-cases
#9
Wing Ting To, Dirk De Ridder, Tomas Menovsky, John Hart, Sven Vanneste
BACKGROUND: The anterior cingulate cortex (ACC) has been implicated in both cognitive and emotional processing, with cognitive information proposed to be processed through the dorsal/caudal ACC and emotional information through the rostral/ventral ACC. OBJECTIVE: The objective of this study is to investigate the role of the dorsal anterior cingulate cortex (dACC) in cognitive and emotional processing using a cognitive and emotional counting Stroop task in two patients in whom abnormalities in the dACC were identified and treated...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28577171/a-randomized-nonblinded-extension-study-of-single-incision-versus-transobturator-midurethral-sling-in-women-with-stress-urinary-incontinence
#10
René P Schellart, Sandra E Zwolsman, Jean-Philippe Lucot, Dirk J M K de Ridder, Marcel G W Dijkgraaf, Jan-Paul W R Roovers
INTRODUCTION AND HYPOTHESIS: Midurethral sling procedures are the first surgical option in women undergoing surgery for stress urinary incontinence (SUI). Single-incision midurethral-slings (SIMS) were designed to provide similar efficacy to traditional midurethral slings but with reduced morbidity. In this international trial we compared the efficacy of a SIMS (MiniArc) and a transobturator standard midurethral sling (SMUS; Monarc) in the treatment of SUI in terms of subjective and objective cure rates and morbidity over a long-term follow-up...
June 2, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28572760/a-quantitative-electroencephalography-study-on-cochlear-implant-induced-cortical-changes-in-single-sided-deafness-with-tinnitus
#11
Jae-Jin Song, Kyungsoo Kim, Woongsang Sunwoo, Griet Mertens, Paul Van de Heyning, Dirk De Ridder, Sven Vanneste, Sang-Youp Lee, Kyung-Joon Park, Hongsoo Choi, Ji-Woong Choi
The mechanism of tinnitus suppression after cochlear implantation (CI) in single-sided deafness (SSD) is not fully understood. In this regard, by comparing pre- and post-CI quantitative electroencephalography (qEEG), we explored cortical changes relevant to tinnitus improvement. In SSD patients who underwent CI, qEEG data were collected: (1) before CI, (2) 6 months post-operatively with CI-on, and (3) 30 min after CI-off and source-localized cortical activity/functional connectivity analyses were performed...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28544432/are-10-khz-stimulation-and-burst-stimulation-fundamentally-the-same
#12
REVIEW
Dirk De Ridder, Sanjaya Perera, Sven Vanneste
BACKGROUND: Spinal cord stimulation (SCS) is routinely used for intractable pain syndromes. For SCS to be efficacious the painful area needs to be covered by SCS induced paresthesia symptoms. Recently, novel stimulation designs have been developed for spinal cord stimulation (SCS) that are superior to classical spinal cord stimulation and exert their effects without the mandatory paresthesia. Two such stimulation designs are burst stimulation and 10 kHz stimulation. OBJECTIVE: Whereas the mechanism of action of burst SCS has been partly elucidated, in that it modulates the medial pain pathway in contrast to tonic stimulation, the mechanism of action of 10 kHz SCS is still enigmatic...
October 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28528813/surgical-treatment-of-female-stress-urinary-incontinence-do-tapes-stand-the-test-of-time
#13
EDITORIAL
Frank Van der Aa, Jan Deprest, Dirk De Ridder
No abstract text is available yet for this article.
May 18, 2017: European Urology
https://www.readbyqxmd.com/read/28491021/corrigendum-brain-metabolic-changes-in-rats-following-acoustic-trauma
#14
Jun He, Yejin Zhu, Jiye Aa, Paul F Smith, Dirk De Ridder, Guangji Wang, Yiwen Zheng
[This corrects the article on p. 148 in vol. 11, PMID: 28392756.].
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28480203/deep-brain-stimulation-of-the-ventral-anterior-limb-of-the-internal-capsule-for-treatment-resistant-depression-possibilities-limits-and-future-perspectives
#15
EDITORIAL
Dirk De Ridder, Sven Vanneste, Berthold Langguth
No abstract text is available yet for this article.
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28415723/auranofin-radiosensitizes-tumor-cells-through-targeting-thioredoxin-reductase-and-resulting-overproduction-of-reactive-oxygen-species
#16
Hui Wang, Soumaya Bouzakoura, Sven de Mey, Heng Jiang, Kalun Law, Inès Dufait, Cyril Corbet, Valeri Verovski, Thierry Gevaert, Olivier Feron, Dirk Van den Berge, Guy Storme, Mark De Ridder
Auranofin (AF) is an anti-arthritic drug considered for combined chemotherapy due to its ability to impair the redox homeostasis in tumor cells. In this study, we asked whether AF may in addition radiosensitize tumor cells by targeting thioredoxin reductase (TrxR), a critical enzyme in the antioxidant defense system operating through the reductive protein thioredoxin. Our principal findings in murine 4T1 and EMT6 tumor cells are that AF at 3-10 μM is a potent radiosensitizer in vitro, and that at least two mechanisms are involved in TrxR-mediated radiosensitization...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28392756/brain-metabolic-changes-in-rats-following-acoustic-trauma
#17
Jun He, Yejin Zhu, Jiye Aa, Paul F Smith, Dirk De Ridder, Guangji Wang, Yiwen Zheng
Acoustic trauma is the most common cause of hearing loss and tinnitus in humans. However, the impact of acoustic trauma on system biology is not fully understood. It has been increasingly recognized that tinnitus caused by acoustic trauma is unlikely to be generated by a single pathological source, but rather a complex network of changes involving not only the auditory system but also systems related to memory, emotion and stress. One obvious and significant gap in tinnitus research is a lack of biomarkers that reflect the consequences of this interactive "tinnitus-causing" network...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28371170/state-of-the-art-novel-applications-for-cortical-stimulation
#18
REVIEW
Dirk De Ridder, Sanjaya Perera, Sven Vanneste
OBJECTIVE: Electrical stimulation via implanted electrodes that overlie the cortex of the brain is an upcoming neurosurgical technique that was hindered for a long time by insufficient knowledge of how the brain functions in a dynamic, physiological, and pathological way, as well as by technological limitations of the implantable stimulation devices. METHODS: This paper provides an overview of cortex stimulation via implantable devices and introduces future possibilities to improve cortex stimulation...
April 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28321566/differential-effects-of-bifrontal-and-occipital-nerve-stimulation-on-pain-and-fatigue-using-transcranial-direct-current-stimulation-in-fibromyalgia-patients
#19
Wing Ting To, Evan James, Jan Ost, John Hart, Dirk De Ridder, Sven Vanneste
Fibromyalgia is a disorder characterized by widespread musculoskeletal pain frequently accompanied by other symptoms such as fatigue. Moderate improvement from pharmacological and non-pharmacological treatments have proposed non-invasive brain stimulation techniques such as transcranial direct current stimulation (tDCS) to the occipital nerve (more specifically the C2 area) or to the dorsolateral prefrontal cortex (DLPFC) as potential treatments. We aimed to explore the effectiveness of repeated sessions of tDCS (eight sessions) targeting the C2 area and DLPFC in reducing fibromyalgia symptoms, more specifically pain and fatigue...
July 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28260394/evidence-for-behaviorally-segregated-spatiotemporally-overlapping-subnetworks-in-phantom-sound-perception
#20
Anusha Mohan, Nicole Moreno, Jae-Jin Song, Dirk De Ridder, Sven Vanneste
One of the most intriguing questions in neuroscience is to understand the mechanism of information transfer between different brain areas. Recently, network theory has gained traction and is at the forefront of providing a possible explanation to not only the mechanism of information transfer but also in the identification of different neuropathologies. The perception of a phantom ringing in the ear called tinnitus, similar to other neuropathologies, has been shown to be accompanied by aberrant functional connectivity between different brain areas...
April 2017: Brain Connectivity
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