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exosomes inflammation fibrosis liver

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https://www.readbyqxmd.com/read/26939970/hepatic-sinusoids-in-liver-injury-inflammation-and-fibrosis-new-pathophysiological-insights
#1
REVIEW
Thomas Greuter, Vijay H Shah
Changes of hepatic sinusoids are crucial in the pathogenesis of liver cirrhosis and portal hypertension. Liver injury leads to distinct morphological abnormalities such as loss of sinusoidal fenestration, vasoconstriction, and angiogenesis as well as molecular changes. Communication between the two key cells in this hepatic microenvironment-hepatic stellate cells (HSC) and sinusoidal endothelial cells (SEC)-has been studied for many years and several canonical pathways have been elucidated, such as decreased eNOS activity or increased PDGF and TGF-β production leading to activation and migration of HSC...
June 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/23152743/comprehensive-mirna-expression-analysis-in-peripheral-blood-can-diagnose-liver-disease
#2
Yoshiki Murakami, Hidenori Toyoda, Toshihito Tanahashi, Junko Tanaka, Takashi Kumada, Yusuke Yoshioka, Nobuyoshi Kosaka, Takahiro Ochiya, Y-h Taguchi
BACKGROUND: miRNAs circulating in the blood in a cell-free form have been acknowledged for their potential as readily accessible disease markers. Presently, histological examination is the golden standard for diagnosing and grading liver disease, therefore non-invasive options are desirable. Here, we investigated if miRNA expression profile in exosome rich fractionated serum could be useful for determining the disease parameters in patients with chronic hepatitis C (CHC). METHODOLOGY: Exosome rich fractionated RNA was extracted from the serum of 64 CHC and 24 controls with normal liver (NL)...
2012: PloS One
https://www.readbyqxmd.com/read/23002959/exosomes-derived-from-human-umbilical-cord-mesenchymal-stem-cells-alleviate-liver-fibrosis
#3
Tingfen Li, Yongmin Yan, Bingying Wang, Hui Qian, Xu Zhang, Li Shen, Mei Wang, Ying Zhou, Wei Zhu, Wei Li, Wenrong Xu
Mesenchymal stem cells (MSCs) have been considered as an attractive tool for the therapy of diseases. Exosomes excreted from MSCs can reduce myocardial ischemia/reperfusion damage and protect against acute tubular injury. However, whether MSC-derived exosomes can relieve liver fibrosis and its mechanism remain unknown. Previous work showed that human umbilical cord-MSCs (hucMSCs) transplanted into acutely injured and fibrotic livers could restore liver function and improve liver fibrosis. In this study, it was found that transplantation of exosomes derived from hucMSC (hucMSC-Ex) reduced the surface fibrous capsules and got their textures soft, alleviated hepatic inflammation and collagen deposition in carbon tetrachloride (CCl4)-induced fibrotic liver...
March 15, 2013: Stem Cells and Development
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