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https://www.readbyqxmd.com/read/28801974/heritability-estimates-of-endurance-related-phenotypes-a-systematic-review-and-meta-analysis
#1
Eri Miyamoto-Mikami, Hirofumi Zempo, Noriyuki Fuku, Naoki Kikuchi, Motohiko Miyachi, Haruka Murakami
The aim of this study was to clarify heritability estimates for endurance-related phenotypes and the underlying factors affecting these estimates. A systematic literature search was conducted for studies reporting heritability estimates of endurance-related phenotypes using the PubMed database (up to September 30, 2016). Studies that estimated the heritability of maximal oxygen uptake (VO2 max), submaximal endurance phenotypes, and endurance performance were selected. The weighted mean heritability for endurance-related phenotypes was calculated using a random-effects model...
August 12, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28782653/a-maximal-incremental-effort-alters-tear-osmolarity-depending-on-the-fitness-level-in-military-helicopter-pilots
#2
Jesús Vera Vilchez, Raimundo Jimenez, Iker Madinabeitia, Nerijus Masiulis, David Cárdenas
PURPOSE: Fitness level modulates the physiological responses to exercise for a variety of indices. While intense bouts of exercise have been demonstrated to increase tear osmolarity (Tosm), it is not known if fitness level can affect the Tosm response to acute exercise. This study aims to compare the effect of a maximal incremental test on Tosm between trained and untrained military helicopter pilots. METHODS: Nineteen military helicopter pilots (ten trained and nine untrained) performed a maximal incremental test on a treadmill...
August 4, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28780577/drug-treatment-effects-on-outcomes-in-heart-failure-with-preserved-ejection-fraction-a-systematic-review-and-meta-analysis
#3
Sean Lee Zheng, Fiona T Chan, Adam A Nabeebaccus, Ajay M Shah, Theresa McDonagh, Darlington O Okonko, Salma Ayis
BACKGROUND: Clinical drug trials in patients with heart failure and preserved ejection fraction have failed to demonstrate improvements in mortality. METHODS: We systematically searched Medline, Embase and the Cochrane Central Register of Controlled Trials for randomised controlled trials (RCT) assessing pharmacological treatments in patients with heart failure with left ventricular (LV) ejection fraction≥40% from January 1996 to May 2016. The primary efficacy outcome was all-cause mortality...
August 5, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28759130/the-joint-impact-of-prediagnostic-inflammatory-markers-and-cardiorespiratory-fitness-on-the-risk-of-cancer-mortality
#4
Perfenia Paul Pletnikoff, Jari A Laukkanen, Tomi-Pekka Tuomainen, Sudhir Kurl
Independently, cardiorespiratory fitness (CRF), C-reactive protein (CRP) and leukocyte count have been shown to predict cancer death. Little is known about the joint impact of CRF and prediagnostic markers of inflammation, particularly leukocyte count and CRP, and their prognostic value with cancer death. The aim of this study was to explore the association between prediagnostic inflammatory markers and CRF with cancer mortality. A population-based cohort of 2270 men from Eastern Finland with no cancer history at baseline participated in the study...
July 31, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28751372/energy-cost-of-running-instability-evaluated-with-wearable-trunk-accelerometry
#5
Kurt Heinrich Schütte, Saint Sackey, Rachel Venter, Benedicte Vanwanseele
Maintaining stability under dynamic conditions is an inherent challenge to bipedal running. This challenge may impose an energetic cost (Ec) thus hampering endurance running performance, yet the underlying mechanisms are not clear. Wireless tri-axial trunk accelerometry is a simple tool that could be used to unobtrusively evaluate these mechanisms. Here, we test a cost of instability hypothesis by examining the contribution of trunk accelerometry-based measures (tri-axial root mean square, step and stride regularity, and sample entropy) to inter-individual variance in Ec (kcal...
July 27, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28737586/comparison-of-acute-physiological-and-psychological-responses-between-moderate-intensity-continuous-exercise-and-three-regimes-of-high-intensity-training
#6
Nicole Green, Timothy Wertz, Zachary LaPorta, Adam Mora, Jasmine Serbas, Todd A Astorino
High intensity interval training (HIIT) elicits similar physiological adaptations as moderate intensity continuous training (MICT) despite less time commitment. However, there is debate whether HIIT is more aversive than MICT. This study compared physiological and perceptual responses between MICT and three regimes of HIIT. Nineteen active adults (age = 24.0 ± 3.3 yr) unfamiliar with HIIT initially performed ramp exercise to exhaustion to measure maximal oxygen uptake (VO2 max) and determine workload for subsequent sessions, whose order was randomized...
July 19, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28737294/a-call-to-action-towards-an-evidence-based-approach-to-using-verbal-encouragement-during-maximal-exercise-testing
#7
REVIEW
Adrian W Midgley, David C Marchant, Andrew R Levy
By definition, maximal exercise testing inherently requires participants to give a maximal effort. This is an important practical issue as submaximal efforts can produce invalid test results. Verbal encouragement is commonly used to motivate participants to maintain or increase effort investment during maximal exercise testing. Accordingly, studies have reported significant increases in time to exhaustion of between 8% and 18% during VO2max and multistage shuttle run tests, and a significant 30·5 m mean increase in 6-min walk test distance...
July 24, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28706467/ketogenic-diet-benefits-body-composition-and-well-being-but-not-performance-in-a-pilot-case-study-of-new-zealand-endurance-athletes
#8
Caryn Zinn, Matthew Wood, Mikki Williden, Simon Chatterton, Ed Maunder
BACKGROUND: Low-carbohydrate, high-fat and ketogenic diets are increasingly adopted by athletes for body composition and sports performance enhancements. However, as yet, there is no consensus on their efficacy in improving performance. There is also no comprehensive literature on athletes' experiences while undertaking this diet. The purpose of this pilot work was two-fold: i. to examine the effects of a non-calorie controlled ketogenic diet on body composition and performance outcomes of endurance athletes, and ii...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28697553/impact-of-training-volume-and-intensity-on-rbc-nos-no-pathway-and-endurance-capacity
#9
Christina Koliamitra, Bastian Holtkamp, Philipp Zimmer, Wilhelm Bloch, Marijke Grau
BACKGROUND: Acute exercise increases red blood cell-nitric oxide synthase (RBC-NOS) activation and RBC deformability but the effect of regular training remains unclear. OBJECTIVE: To detect the chronic effect of enduring moderate and high intensity training on the RBC-NOS/NO pathway and to detect a relation between RBC deformability and endurance capacity. METHODS: 38 healthy male subjects were randomly assigned to one of three training groups: High Volume Training (HVT; 120-140 beats per minute (bpm)), High Intensity Training (HIT; 160-180 bpm) and Moderate Intensity Training (MIT; 140-160 bpm)...
July 3, 2017: Biorheology
https://www.readbyqxmd.com/read/28685860/exercise-mediated-modulation-of-autophagy-in-skeletal-muscle
#10
REVIEW
Marcos Martin-Rincon, David Morales-Alamo, Jose A L Calbet
Although exercise exerts multiple beneficial health effects, it may also damage cellular structures. Damaged elements are continuously degraded and its constituents recycled to produce renovated structures through a process called autophagy, which is essential for the adaptation to training. Autophagy is particularly active in skeletal muscle, where it can be evaluated by using specific molecular markers of activation (unc-51-like kinase 1 (ULK1) phosphorylation) and specific proteins indicating increased autophagosome content (increased total LC3, LC3-II, LC3-II/LC3-I ratio)...
July 7, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28676154/new-generalized-equation-for-predicting-maximal-oxygen-uptake-from-the-fitness-registry-and-the-importance-of-exercise-national-database
#11
Peter Kokkinos, Leonard A Kaminsky, Ross Arena, Jiajia Zhang, Jonathan Myers
Impaired cardiorespiratory fitness (CRF) is closely linked to chronic illness and associated with adverse events. The American College of Sports Medicine (ACSM) regression equations (ACSM equations) developed to estimate oxygen uptake have known limitations leading to well-documented overestimation of CRF, especially at higher work rates. Thus, there is a need to explore alternative equations to more accurately predict CRF. We assessed maximal oxygen uptake (VO2 max) obtained directly by open-circuit spirometry in 7,983 apparently healthy subjects who participated in the Fitness Registry and the Importance of Exercise National Database (FRIEND)...
August 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28675760/association-of-perceived-physical-health-and-physical-fitness-in-two-swedish-national-samples-from-1990-and-2015
#12
S J G Olsson, E Ekblom-Bak, B Ekblom, L V Kallings, Ö Ekblom, M Börjesson
BACKGROUND: Perceived health and physical fitness have been shown to correlate, and low levels of either variable increase the risk for future illness and mortality. However, risk factors and their interrelationship may vary between societies and over time. In this study, the associations of physical fitness and perceived health were therefore assessed in two Swedish national samples 25 years apart. METHODS: Perceived physical health, dichotomized as "good" or "bad", maximal oxygen uptake (VO2 max), counter movement jump (CMJ), balance (one-legged 60 second stance), and self-reported demographics and lifestyle were recorded in two cross-sectional samples (sample size, number of eligible participants) of Swedish adults, aged 20 - 65 years, in 1990 - 1991 (2203, 1365), and 2013 - 2015 (3357, 422)...
July 4, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28669689/effects-of-erythropoietin-on-cycling-performance-of-well-trained-cyclists-a-double-blind-randomised-placebo-controlled-trial
#13
Jules A A C Heuberger, Joris I Rotmans, Pim Gal, Frederik E Stuurman, Juliëtte van 't Westende, Titiaan E Post, Johannes M A Daniels, Matthijs Moerland, Peter L J van Veldhoven, Marieke L de Kam, Herman Ram, Olivier de Hon, Jelle J Posthuma, Jacobus Burggraaf, Adam F Cohen
BACKGROUND: Substances that potentially enhance performance (eg, recombinant human erythropoietin [rHuEPO]) are considered doping and are therefore forbidden in sports; however, the scientific evidence behind doping is frequently weak. We aimed to determine the effects of rHuEPO treatment in well trained cyclists on maximal, submaximal, and race performance and on safety, and to present a model clinical study for doping research on other substances. METHODS: We did this double-blind, randomised, placebo-controlled trial at the Centre for Human Drug Research in Leiden (Netherlands)...
June 29, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28638349/cardiorespiratory-coordination-in-repeated-maximal-exercise
#14
Sergi Garcia-Retortillo, Casimiro Javierre, Robert Hristovski, Josep L Ventura, Natàlia Balagué
Increases in cardiorespiratory coordination (CRC) after training with no differences in performance and physiological variables have recently been reported using a principal component analysis approach. However, no research has yet evaluated the short-term effects of exercise on CRC. The aim of this study was to delineate the behavior of CRC under different physiological initial conditions produced by repeated maximal exercises. Fifteen participants performed 2 consecutive graded and maximal cycling tests. Test 1 was performed without any previous exercise, and Test 2 6 min after Test 1...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28605306/behaviour-tracking-and-three-year-longitudinal-associations-between-physical-activity-screen-time-and-fitness-among-young-children
#15
Morgan Potter, John C Spence, Normand Boulé, Jodie A Stearns, Valerie Carson
PURPOSE: Understanding the correlates of children's fitness as they develop is needed. The objectives of this study were to: (1) examine the longitudinal associations between physical activity (PA), screen time (ST), and fitness, (2) determine if sex moderates associations, and (3) track PA and ST over three years. METHODS: Findings are based on 649 children (baseline: 4.5±0.5 years; follow-up: 7.8±0.6 years) from Edmonton, Canada. Parental-reported hour/week of PA and ST were measured at baseline and three years later...
June 12, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28599381/exercise-intervention-on-cardiovascular-disease-risk-factors-in-a-university-population-in-the-united-arab-emirates
#16
Sarah Dalibalta, Fatemeh Mirshafiei, Gareth Davison
Objective 1) To assess the incidence of cardiovascular disease (CVD) risk factors in a university population, and 2) to investigate the effects of an 8-week exercise intervention on CVD risk factors. Methods Forty-six students participated in this study. Baseline cardiorespiratory fitness was assessed using maximal oxygen uptake (VO2 max). Total cholesterol, high-density lipoprotein (HDL)-cholesterol and triglycerides were measured. Body mass index (BMI), waist-to-hip circumference ratio (WHR), blood pressure (BP) and arterial stiffness were also assessed...
May 25, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28557857/consumption-of-a-5-mg-melatonin-supplement-does-not-affect-32-2-kilometer-cycling-time-trial-performance
#17
Kyle J Brandenberger, Christopher P Ingalls, Jeffrey C Rupp, J Andrew Doyle
Some studies suggest that exogenous melatonin supplementation may improve athletic performance in hot humid environments because of its precooling effect. However, melatonin is also consumed as a sleep aid for its depressive effects on the central nervous system, which may hinder performance. Therefore, this study was conducted to determine whether consuming a 5 mg supplement of melatonin would affect performance in a laboratory-simulated 32.2 kilometer cycling time trial. The time trial was conducted in a thermoneutral environment to separate CNS depressive effects of the melatonin from the cooling effects...
May 25, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28556577/clinical-and-neurobiological-effects-of-aerobic-exercise-in-dental-phobia-a-randomized-controlled-trial
#18
Brigitt L Lindenberger, Jens Plag, Sarah Schumacher, Katharina Gaudlitz, Sophie Bischoff, Thomas Bobbert, Fernando Dimeo, Moritz B Petzold, Clemens Kirschbaum, Zsuzsa Dudás, Andreas Ströhle
BACKGROUND: Physical activity has shown to be effective in anxiety disorders. For specific phobia, no studies are available that systematically examined the effects of an aerobic exercise intervention on phobic fear within a randomized-controlled design. Therefore, we investigated the acute effect of a standardized aerobic training on clinical symptoms of dental phobia as well as on stress-related neurobiological markers. METHODS: Within a crossover design, 30 patients with dental phobia (mean age: 34...
May 26, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28547918/exercise-with-weight-loss-improves-adipose-tissue-and-skeletal-muscle-markers-of-fatty-acid-metabolism-in-postmenopausal-women
#19
Heidi K Ortmeyer, Andrew P Goldberg, Alice S Ryan
OBJECTIVE: The effects of 6-month weight loss (WL) versus aerobic exercise training (AEX)+WL on fat and skeletal muscle markers of fatty acid metabolism were determined in normal (NGT) and impaired (IGT) glucose tolerant African-American and Caucasian postmenopausal women with overweight/obesity. METHODS: Fat (gluteal and abdominal) lipoprotein lipase (LPL), skeletal muscle LPL, acyl-CoA synthase (ACS), ß-hydroxacyl-CoA dehydrogenase, carnitine palmitoyltransferase (CPT-1), and citrate synthase (CS) activities were measured at baseline (n = 104) and before and after WL (n = 34) and AEX+WL (n = 37)...
July 2017: Obesity
https://www.readbyqxmd.com/read/28544643/adaptations-to-endurance-training-depend-on-exercise-induced-oxidative-stress-exploiting-redox-inter-individual-variability
#20
Nikos V Margaritelis, Anastasios A Theodorou, Vassilis Paschalis, Aristidis S Veskoukis, Konstantina Dipla, Andreas Zafeiridis, George Panayiotou, Ioannis S Vrabas, Antonios Kyparos, Michalis G Nikolaidis
AIM: The aim of the present study was to reveal the role of reactive oxygen and nitrogen species (RONS) in exercise adaptations under physiological in vivo conditions and without the interference from other exogenous redox agents (e.g., a pro-oxidant or antioxidant). METHODS: We invented a novel methodological set-up that exploited the large redox inter-individual variability in exercise responses. More specifically, we used exercise-induced oxidative stress as the "classifier" measure (i...
May 24, 2017: Acta Physiologica
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