keyword
MENU ▼
Read by QxMD icon Read
search

Exosomes liver

keyword
https://www.readbyqxmd.com/read/29749537/exosome%C3%A2-encapsulated-microrna%C3%A2-23b-as-a-minimally-invasive-liquid-biomarker-for-the-prediction-of-recurrence-and-prognosis-of-gastric-cancer-patients-in-each-tumor-stage
#1
Yoshimasa Kumata, Hisae Iinuma, Yusuke Suzuki, Daisuke Tsukahara, Hironori Midorikawa, Yuichi Igarashi, Naruyoshi Soeda, Takashi Kiyokawa, Masahiro Horikawa, Ryoji Fukushima
Recently, exosome‑encapsulated microRNAs (miRNAs) have been attracting attention as stable and minimally invasive biomarkers in cancer patients. The aim of the present study was to clarify the value of plasma exosomal microRNA‑23b (miR‑23b) as a diagnostic and prognostic biomarker in gastric cancer (GC) patients at each tumor stage. We first selected recurrence specific exosomal miRNA by miRNA microarray from 6 GC patients (stage I) with or without recurrence, and 3 healthy volunteers. In this analysis, miR‑23b demonstrated the most significant change...
May 8, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29740437/targeting-and-therapy-of-glioblastoma-in-a-mouse-model-using-exosomes-derived-from-natural-killer-cells
#2
Liya Zhu, Ji Min Oh, Prakash Gangadaran, Senthilkumar Kalimuthu, Se Hwan Baek, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Objective: Glioblastoma is a highly aggressive primary brain tumor that is resistant to radiotherapy and chemotherapy. Natural killer (NK) cells have been used to treat incurable cancers. Recent studies have investigated the effectiveness of NK-cell-derived exosomes (NK-Exo) for treating incurable cancers such as melanoma, leukemia, and neuroblastoma; however, NK-Exo have not been used to treat glioblastoma. In the present study, we investigated the antitumor effects of NK-Exo against aggressive glioblastoma both in vitro and in vivo and determined the tumor-targeting ability of NK-Exo by performing fluorescence imaging...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29738828/time-course-expression-profile-and-diagnostic-potential-of-a-mirna-panel-in-exosomes-and-total-serum-in-acute-liver-injury
#3
Tarek K Motawi, Mohamed R Mohamed, Nancy N Shahin, Mohamed A M Ali, May A Azzam
Circulating miRNAs have recently emerged as attractive candidates for biomarker discovery. However, they have a variant distribution in circulation, and the diagnostic significance of their compartmentalization is yet to be elucidated. This study explored the time-course expression profile and the diagnostic potential of miRNAs-122a-5p, 192-5p, 193a-3p and 194-5p in exosomal and total serum compartments in two rat models of acute liver injury (ALI)1 . Exosomes were isolated and characterized in terms of morphology, size and CD-63 surface marker expression...
May 5, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29725020/hcc-derived-exosomes-elicit-hcc-progression-and-recurrence-by-epithelial-mesenchymal-transition-through-mapk-erk-signalling-pathway
#4
Lu Chen, Piao Guo, Yuchao He, Ziye Chen, Liwei Chen, Yi Luo, Lisha Qi, Yuanyuan Liu, Qiang Wu, Yunlong Cui, Feng Fang, Xiaofang Zhang, Tianqiang Song, Hua Guo
Liver cancer is the second most common cause of cancer-related death worldwide. Approximately 70-90% of primary liver cancers are hepatocellular carcinoma (HCC). Currently, HCC patient prognosis is unsatisfactory due to high metastasis and/or post-surgical recurrence rates. Therefore, new therapeutic methods for inhibiting metastasis and recurrence are urgently needed. Exosomes are small lipid-bilayer vesicles that are implicated in tumour development and metastasis. Rab27a, a small GTPase, regulates exosome secretion by mediating multivesicular endosome docking at the plasma membrane...
May 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29717059/fed-exosome-extracellular-vesicles-and-cell-cell-communication-in-metabolic-regulation
#5
REVIEW
Isabella Samuelson, Antonio J Vidal-Puig
Extracellular vesicles (EVs) have emerged as a novel messaging system of the organism, mediating cell-cell and interorgan communication. Through their content of proteins and nucleic acids, as well as membrane proteins and lipid species, EVs can interact with and modulate the function of their target cells. The regulation of whole-body metabolism requires cross-talk between key metabolic tissues including adipose tissue (AT), the liver and skeletal muscle. Furthermore, the regulation of nutrient/energy allocation during pregnancy requires co-ordinated communication between the foetus and metabolic organs of the mother...
May 1, 2018: Essays in Biochemistry
https://www.readbyqxmd.com/read/29709702/tumor-released-exosomal-circular-rna-pde8a-promotes-invasive-growth-via-the-mir-338-macc1-met-pathway-in-pancreatic-cancer
#6
Zhonghu Li, Wu Yanfang, Jie Li, Peng Jiang, Tao Peng, Kai Chen, Xin Zhao, Yujun Zhang, Ping Zhen, Jin Zhu, Xiaowu Li
Circular RNA (circ-RNA) and exosomes have recently been shown to play important roles in different tumors. However, the functions and regulatory mechanisms of exosomal circ-RNA in pancreatic ductal adenocarcinoma (PDAC) tumor progression remain unclear. Here, we identified a circular RNA (circ-PDE8A) from liver-metastatic PDAC cells by microarray analysis, detected its expression levels in clinical tissues and found that high circ-PDE8A expression was correlated with lymphatic invasion, TNM stage and a poor survival rate of PDAC patients...
April 27, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29686713/human-umbilical-cord-msc-derived-exosomes-suppress-the-development-of-ccl-4-induced-liver-injury-through-antioxidant-effect
#7
Wenqian Jiang, Youwen Tan, Mengjie Cai, Ting Zhao, Fei Mao, Xu Zhang, Wenrong Xu, Zhixin Yan, Hui Qian, Yongmin Yan
Mesenchymal stem cells (MSCs) have been increasingly applied into clinical therapy. Exosomes are small (30-100 nm in diameter) membrane vesicles released by different cell types and possess the similar functions with their derived cells. Human umbilical cord MSC-derived exosomes (hucMSC-Ex) play important roles in liver repair. However, the effects and mechanisms of hucMSC-Ex on liver injury development remain elusive. Mouse models of acute and chronic liver injury and liver tumor were induced by carbon tetrachloride (CCl4 ) injection, followed by administration of hucMSC-Ex via the tail vein...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29674685/exosomal-circrna_100284-from-arsenite-transformed-cells-via-microrna-217-regulation-of-ezh2-is-involved-in-the-malignant-transformation-of-human-hepatic-cells-by-accelerating-the-cell-cycle-and-promoting-cell-proliferation
#8
Xiangyu Dai, Chao Chen, Qianlei Yang, Junchao Xue, Xiong Chen, Baofei Sun, Fei Luo, Xinlu Liu, Tian Xiao, Hui Xu, Qian Sun, Aihua Zhang, Qizhan Liu
Intercellular communication between malignant cells and neighboring nonmalignant cells is involved in carcinogenesis. In the progression of carcinogenesis, exosomes are messengers for intercellular communication. Circular RNAs (circRNAs) are noncoding RNAs with functions that include regulation of the cell cycle and proliferation. However, the functions of exosomal circRNAs are not clear. The present research aimed to determine whether circRNAs secreted from arsenite-transformed human hepatic epithelial (L-02) cells are transferred into normal L-02 cells and become functionally active in the normal cells...
April 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29660691/proteomic-analysis-of-liquid-biopsy-from-tumor-draining-vein-indicates-that-high-expression-of-exosomal-ecm1-is-associated-with-relapse-in-stage-i-iii-colon-cancer
#9
Sandra Santasusagna, Isabel Moreno, Alfons Navarro, Joan J Castellano, Francisco Martinez, Raquel Hernández, Carmen Muñoz, Mariano Monzo
BACKGROUND: The analysis of exosomes in blood obtained from the tumor-draining mesenteric vein (MV) can identify tumor biomarkers before they reach target organs and form the premetastatic niche where circulating tumor cells can anchor. Our group has recently shown that microRNAs in plasma from the MV-but not the peripheral vein (PV)-have been related to liver metastases in colon cancer (CC) patients. Here we examine the exosomal protein cargo in plasma from the MV and paired PV in 31 CC patients...
April 13, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29660237/multiplexed-isobaric-tag-based-profiling-of-seven-murine-tissues-following-in-vivo-nicotine-treatment-using-a-minimalistic-proteomics-strategy
#10
Joao A Paulo, Mark P Jedrychowski, Edward T Chouchani, Lawrence Kazak, Steven P Gygi
Nicotine is a major addictive compound in tobacco and a component of smoking-related products, such as e-cigarettes. Once internalized, nicotine can perturb many cellular pathways and can induce alterations in proteins across different cell types, however the mechanisms thereof remain undetermined. We hypothesize that both tissue-specific and global protein abundance alterations result from nicotine exposure. As such, we present the first proteome analysis of multiple tissues from nicotine-exposed mice. We treat mice via oral administration of nicotine at 200μg/mL in drinking water for 21 days...
April 16, 2018: Proteomics
https://www.readbyqxmd.com/read/29627574/exosomes-secreted-by-placental-stem-cells-selectively-inhibit-growth-of-aggressive-prostate-cancer-cells
#11
Taylor C Peak, Prakash Praharaj, Gati K Panigrahi, Michael Doyle, Yixin Su, Isabel R Schlaepfer, Ravi Singh, Donald J Vander Griend, Julie Alickson, Ashok Hemal, Anthony Atala, Gagan Deep
The current paradigm in the development of new cancer therapies is the ability to target tumor cells while avoiding harm to noncancerous cells. Furthermore, there is a need to develop novel therapeutic options against drug-resistant cancer cells. Herein, we characterized the placental-derived stem cell (PLSC) exosomes (PLSCExo ) and evaluated their anti-cancer efficacy in prostate cancer (PCa) cell lines. Nanoparticle tracking analyses revealed the size distribution (average size 131.4 ± 0.9 nm) and concentration of exosomes (5...
April 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29621784/exosomes-derived-from-dendritic-cells-attenuate-liver-injury-by-modulating-the-balance-of-treg-and-th17-cells-after-ischemia-reperfusion
#12
Lei Zheng, Zhi Li, Wei Ling, Deming Zhu, Zhiwen Feng, Lianbao Kong
BACKGROUND/AIMS: The present study aimed to evaluate the effects as well as the underlying mechanisms of bone marrow-derived dendritic cells (BMDCs) and exosomes produced by BMDCs (DEXs) on hepatic ischemia-reperfusion (I/R) injury (IRI). METHODS: Primary hepatocytes were isolated and used to mimic the liver IR microenvironment. BMDCs were induced and characterized both biochemically with a flow cytometer (FCM) and biophysically with a microscope. Then, we exposed BMDCs to the supernatants from primary hepatocytes and evaluated the maturation of BMDCs by FCM...
March 29, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29621595/extracellular-vesicles-as-potential-biomarkers-for-alcohol-and-drug-induced-liver-injury-and-their-therapeutic-applications
#13
REVIEW
Young-Eun Cho, Byoung-Joon Song, Mohammed Akbar, Moon-Chang Baek
Extracellular vesicles (EVs) are small membranous vesicles originating from various cells and tissues, including the liver parenchymal hepatocytes and nonparenchymal cells such as Kupffer and stellate cells. Recently, the pathophysiological role of EVs, such as exosomes and microvesicles, has been increasingly recognized based on intercellular communications. These EVs travel through the circulating blood and interact with specific cells and then deliver their cargos such as nucleic acids and proteins into recipient cells...
April 3, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29621543/cardiac-specific-delivery-by-cardiac-tissue-targeting-peptide-expressing-exosomes
#14
Hyoeun Kim, Nuri Yun, Dasom Mun, Ji-Young Kang, Seung-Hyun Lee, Hyelim Park, Hyewon Park, Boyoung Joung
Naturally occurring RNA carriers such as exosomes might be an untapped source of effective delivery vehicles. However, if exosomes are to be exploited for therapeutic applications, they must target specific tissues or cell types to avoid off-target effects. This study evaluated whether genetic modification of exosomes could enhance exosome delivery to heart cells and heart tissue without toxicity. Exosomes expressing cardiac-targeting peptide (CTP)-Lamp2b on the exosomal membrane (CTP-Exo) were generated by introducing vectors encoding CTP-Lamp2b into HEK 293 cells...
April 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29599080/exosomes-from-endothelial-progenitor-cells-improve-the-outcome-of-a-murine-model-of-sepsis
#15
Yue Zhou, Pengfei Li, Andrew J Goodwin, James A Cook, Perry V Halushka, Eugene Chang, Hongkuan Fan
Microvascular dysfunction leads to multi-organ failure and mortality in sepsis. Our previous studies demonstrated that administration of exogenous endothelial progenitor cells (EPCs) confers protection in sepsis as evidenced by reduced vascular leakage, improved organ function, and increased survival. We hypothesize that EPCs protect the microvasculature through the exosomes-mediated transfer of microRNAs (miRNAs). Mice were rendered septic by cecal ligation and puncture (CLP), and EPC exosomes were administered intravenously at 4 hr after CLP...
February 27, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29573235/serum-exosomal-micrornas-combined-with-alpha-fetoprotein-as-diagnostic-markers-of-hepatocellular-carcinoma
#16
Yurong Wang, Chunyan Zhang, Pengjun Zhang, Guanghong Guo, Tao Jiang, Xiumei Zhao, Jingjing Jiang, Xueliang Huang, Hongli Tong, Yaping Tian
Exosomal microRNAs have recently been studied as the potential diagnostic marker for various malignancies, including hepatocellular carcinoma (HCC). The aim of this study was to investigate serum exosomal microRNA profiles as HCC diagnostic marker. Transmission electron microscopy and Western blot were used to identify serum exosomes. Deep sequencing was performed to screen differentially expressed microRNAs between HCC (n = 5) and liver cirrhosis (LC, n = 5) groups. Three upregulated and two downregulated microRNAs were selected for qPCR analysis...
March 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29557524/secretomes-reveal-several-novel-proteins-as-well-as-tgf-%C3%AE-1-as-the-top-upstream-regulator-of-metastatic-process-in-breast-cancer
#17
Nuray Erin, Nur Ogan, Azmi Yerlikaya
PURPOSE: Metastatic breast cancer is resistant to many conventional treatments and novel therapeutic targets are needed. We previously isolated subsets of 4T1 murine breast cancer cells which metastasized to liver (4TLM), brain (4TBM), and heart (4THM). Among these cells, 4TLM is the most aggressive one, demonstrating mesenchymal phenotype. Here we compared secreted proteins from 4TLM, 4TBM, and 4THM cells and compared with that of hardly metastatic 67NR cells to detect differentially secreted factors involved in organ-specific metastasis...
March 20, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29550075/polymer-mediated-inhibition-of-pro-invasive-nucleic-acid-damps-and-microvesicles-limits-pancreatic-cancer-metastasis
#18
Ibtehaj Naqvi, Ruwan Gunaratne, Jessica E McDade, Angelo Moreno, Rachel E Rempel, Douglas C Rouse, Silvia Gabriela Herrera, David S Pisetsky, Jaewoo Lee, Rebekah R White, Bruce A Sullenger
Nucleic acid binding polymers (NABPs) have been extensively used as vehicles for DNA and RNA delivery. More recently, we discovered that a subset of these NABPs can also serve as anti-inflammatory agents by capturing pro-inflammatory extracellular nucleic acids and associated protein complexes that promote activation of toll-like receptors (TLRs) in diseases such as lupus erythematosus. Nucleic-acid-mediated TLR signaling also facilitates tumor progression and metastasis in several cancers, including pancreatic cancer (PC)...
February 23, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29530052/exosomal-microrna-32-5p-induces-multidrug-resistance-in-hepatocellular-carcinoma-via-the-pi3k-akt-pathway
#19
Xiao Fu, Mengjie Liu, Shengyang Qu, Jiequn Ma, Yamin Zhang, Tingting Shi, Hongqing Wen, Yujuan Yang, Shuhong Wang, Jing Wang, Kejun Nan, Yu Yao, Tao Tian
BACKGROUND: Multidrug resistance is the main obstacle for hepatocellular carcinoma (HCC) treatment. miR-32-5p is involved in HCC progression but its function in multidrug resistance is still unclear. Here we aim to find out the function of miR-32-5p in inducing multidrug resistance and its underlying mechanisms of transforming sensitive cell to resistant cell. METHODS: We detected the expression of miR-32-5p and PTEN in the multidrug-resistant cell line (Bel/5-FU) and the sensitive cell line (Bel7402), HCC and para-carcinoma liver tissues through real-time PCR...
March 12, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29502100/adipose-derived-exosomes-exert-proatherogenic-effects-by-regulating-macrophage-foam-cell-formation-and-polarization
#20
Zulong Xie, Xuedong Wang, Xinxin Liu, Huaan Du, Changbin Sun, Xin Shao, Jiangtian Tian, Xia Gu, Hailong Wang, Jinwei Tian, Bo Yu
BACKGROUND: Obesity is causally associated with atherosclerosis, and adipose tissue (AT)-derived exosomes may be implicated in the metabolic complications of obesity. However, the precise role of AT-exosomes in atherogenesis remains unclear. We herein aimed to assess the effect of AT-exosomes on macrophage foam cell formation and polarization and subsequent atherosclerosis development. METHODS AND RESULTS: Four types of exosomes isolated from the supernatants of ex vivo subcutaneous AT and visceral AT (VAT) explants that were derived from wild-type mice and high-fat diet (HFD)-induced obese mice were effectively taken up by RAW264...
March 3, 2018: Journal of the American Heart Association
keyword
keyword
81037
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"