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fertility awareness, thyroid,

Annamaria Colao, Giovanna Muscogiuri, Prisco Piscitelli
The Hippocratic tradition emphasized environmental causes of diseases and the need for harmony between the individual and the natural environment as the right philosophy to maintain a good health status. Public awareness and scientific attention concerning environmental pollution is usually focused on the consequent increased risk of developing cancer. Air pollution has been recognized by the World Health Organization (WHO) to cause cardiovascular and respiratroy diseases, as well as lung cancer, after acute/chronic exposure to fine particulates (PM2...
2016: International Journal of Environmental Research and Public Health
Danilo Villagelin, Ana Paula Comarella, Douglas Bernal Tiago, Laura Sterian Ward
OBJECTIVES: Evaluate the management of hypothyroidism in fertile-aged and pregnant women and compare these practices to the recommendations of the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Latin American Thyroid Society, published in 2013. MATERIALS AND METHODS: In the first trimester of 2014, SBEM made available to all members an electronic questionnaire based on clinical scenarios in the management of gestational hypothyroidism. The responses of 406 physicians, most of them endocrinologists, were analyzed...
February 2016: Archives of Endocrinology and Metabolism
Sigrid Svalheim, Line Sveberg, Monika Mochol, Erik Taubøll
Antiepileptic drugs (AEDs) are known to have endocrine side effects in both men and women. These can affect fertility, sexuality, thyroid function, and bone health, all functions of major importance for well-being and quality of life. The liver enzyme inducing antiepileptic drugs (EIAEDs), like phenobarbital, phenytoin, and carbamazepine, and also valproate (VPA), a non-EIAED, are most likely to cause such side effects. AED treatment can alter the levels of different sex hormones. EIAEDs increase sex hormone binding globulin (SHBG) concentrations in both men and women...
May 2015: Seizure: the Journal of the British Epilepsy Association
Maria Chiara Zatelli, Maria Rosaria Ambrosio, Marta Bondanelli, Ettore Degli Uberti
INTRODUCTION: Pituitary function is influenced by several drugs, including anti-depressant, opioids, glucocorticoids, chemotherapeutic agents, immunomodulators and the newly developed tyrosine kinase inhibitors. In most instances, treatment with these drugs negatively affects pituitary function, but in rare cases an activation of specific hypothalamic-pituitary axes may be observed. Several of the observed pituitary side effects are reversible after drug withdrawal, but pituitary function deficiency may persist long-term...
October 2014: Journal of Endocrinological Investigation
Melanie Goldfarb, Stephen F Sener
OBJECTIVE: Differentiated thyroid cancer (DTC) is 1 of the most common cancers in adolescents and young adults (AYA, ages 15-39). Although most AYAs with DTC are considered low risk compared to older patients, there are no specific postoperative radioiodine (RAI) treatment recommendations despite the potential adverse effects specific to this age group, namely secondary malignancies and fertility difficulties. This study compares factors influencing RAI utilization in AYA and older patients...
May 2014: Endocrine Practice
Elyse Pine-Twaddell, Christopher J Romero, Sally Radovick
BACKGROUND: Typically, newborns with congenital hypothyroidism are asymptomatic at birth, having been exposed to euthyroid mothers. However, hypopituitarism may be associated with central hypothyroidism, preserved fertility, and autosomal dominant inheritance, requiring increased attention to thyroid management during pregnancy. PATIENT FINDINGS: A woman with a history of growth hormone deficiency and central hypothyroidism gave birth to a term male neonate appropriate for gestational age...
July 2013: Thyroid: Official Journal of the American Thyroid Association
Howard J A Carp, Carlo Selmi, Yehuda Shoenfeld
Several lines of evidence suggest that autoimmune mechanisms may influence the reproductive life and fertility of both sexes, commonly manifesting as infertility or pregnancy loss. Part of the controversy that characterizes this assumption derives from the overlooked suspect of autoimmune conditions in the absence of symptoms or the limited physician awareness in a gynecological setting. Numerous autoimmune diseases, including but not limited to systemic lupus erythematosus and anti-phospholipid syndrome, may be associated with infertility and pregnancy loss through different putative mechanisms...
May 2012: Journal of Autoimmunity
Marie-Christine Vantyghem, Dries Dobbelaere, Karine Mention, Jean-Louis Wemeau, Jean-Marie Saudubray, Claire Douillard
Most inborn errors of metabolism (IEM) are recessive, genetically transmitted diseases and are classified into 3 main groups according to their mechanisms: cellular intoxication, energy deficiency, and defects of complex molecules. They can be associated with endocrine manifestations, which may be complications from a previously diagnosed IEM of childhood onset. More rarely, endocrinopathies can signal an IEM in adulthood, which should be suspected when an endocrine disorder is associated with multisystemic involvement (neurological, muscular, hepatic features, etc...
2012: Orphanet Journal of Rare Diseases
Claudia Ceccarelli, Domenico Canale, Paolo Vitti
PURPOSE OF REVIEW: Radiometabolic therapy with radioactive iodine (I) is the standard treatment for differentiated thyroid cancer and is also currently the treatment of choice for Graves' disease in the United States. and in most countries. Men younger than 40 years of age represent about 10% of all radiometabolic treatments. Thus, the question arises whether I therapy is able to induce a damage to the fertility potential. RECENT FINDINGS: The different effects caused by I therapy employed in cancer and hyperthyroid patients are reviewed...
November 2008: Current Opinion in Urology
Arthur H Fisher, Steven J Lomasky, Matthew J Fisher, Yael L Oppenheim
OBJECTIVE: To review the association of celiac disease and various endocrine disorders and present the related clinical experience of a 3-physician adult endocrinology practice. METHODS: We provide an overview of the pertinent literature, discuss the clinical manifestations, genetics, and pathogenesis of celiac disease, and describe our clinical experience during a 5-year period. RESULTS: Celiac disease has been associated with numerous disorders, including several conditions treated by endocrinologists-type 1 diabetes mellitus, autoimmune thyroid disease, Addison disease, osteomalacia, secondary hyperparathyroidism, vitamin D or iron deficiency, fertility problems, hypogonadism in men, and autoimmune hypopituitarism...
April 2008: Endocrine Practice
Leonard Wartofsky, Douglas Van Nostrand, Kenneth D Burman
UNLABELLED: Thyroid disease in general, and hypothyroidism in particular, are very common in women. In the USA, the most common cause of primary thyroid deficiency is on an autoimmune basis due to lymphocytic (Hashimoto) thyroiditis. Because there are thyroid hormone receptors in virtually every tissue of the body, the manifestations of hypothyroidism are varied, but problems with abnormal menses, conception, fertility, and pregnancy can be especially troubling in young women. The single most important diagnostic test is measurement of serum thyrotropin (TSH)...
August 2006: Obstetrical & Gynecological Survey
Krinos M Trokoudes, Nicos Skordis, Michalis K Picolos
PURPOSE OF REVIEW: This review highlights the 'gap' in knowledge regarding the contribution of thyroid dysfunction in reproduction. Thyroid dysfunction, which is quite prevalent in the population affects many organs including the male and female gonads, interferes with human reproductive physiology, reduces the likelihood of pregnancy and adversely affects pregnancy outcome, thus becoming relevant in the algorithm of reproductive dysfunction. RECENT FINDINGS: Although menstrual irregularities are common, ovulation and conception can still occur in hypothyroidism, where thyroxine treatment restores a normal menstrual pattern and reverses hormonal changes...
August 2006: Current Opinion in Obstetrics & Gynecology
J J Wichtel
UNLABELLED: SELENIUM AVAILABILITY: Selenium deficiency has been an important source of loss to the pastoral industries of New Zealand. About 30% of farmed land in New Zealand is considered to be selenium-deficient and continued development of soils and pasture will tend to further decrease the concentration of selenium in pasture. BIOLOGICAL FUNCTIONS: Formerly it was believed that all biological functions of selenium in animals could be attributed to the antioxidant activity of the enzyme glutathione peroxidase...
April 1998: New Zealand Veterinary Journal
Mark F H Brougham, Christopher J H Kelnar, W Hamish B Wallace
Whilst many children diagnosed with cancer can now realistically hope for long term survival, the consequences of cancer treatment can be particularly devastating as they enter adolescence and adulthood. Disruption of the endocrine system can result from such treatment, including growth hormone deficiency, problems in normal pubertal progression and thyroid dysfunction. Fertility can also be affected by cancer treatment received as a child, which can have a devastating impact as the patient enters adulthood...
October 2002: Pediatric Rehabilitation
Mati Rahu
The impact of the world's worst nuclear disaster at Chernobyl in 1986 is reviewed within a framework of a triad of fear, rumour and truth. The scope of the accident, Soviet secrecy about it, and the lack of general awareness of, or disregard for, the effects of radiation created a fertile ground for persistent fears and rumours attributing any health problem to Chernobyl. Scientifically correct answers to health issues have been the means to combat disinformation, and to replace interconnected fears, misconceptions and rumours...
February 2003: European Journal of Cancer
B Lunenfeld
The prolongation of life expectancy and the drastic reduction of fertility rate are the primary cause of an aging world. It is projected that the elderly (above 65) will increase within the next 25 years by 82%, whereas the new born only by 3%. Despite the enormous medical progress during the past few decades, the last years of life are still accompanied by increasing ill health and disability. The ability to maintain active and independent living for as long as possible is a crucial factor for aging in health and dignity...
September 2001: Asian Journal of Andrology
J P Grün, S Meuris, P De Nayer, D Glinoer
OBJECTIVE: Human chorionic gonadotrophin (hCG) is known to possess thyroid-stimulating activity. The aim of the present study was to assess the role of hCG in stimulating the maternal thyroid gland in the early stages of normal gestation. STUDY DESIGN: Thirty euthyroid healthy women were investigated prospectively. In each, conception had been assisted by in vitro fertilization techniques, which allowed for the precise determination of gestational age. Women were subdivided into single (n = 17) and twin (n = 13) pregnancies...
June 1997: Clinical Endocrinology
J E Sanders
Bone marrow transplantation is a life-saving procedure for an increasing number of children and young adults. As greater number of patients continue to receive this procedure and are cured of their underlying hematologic disorder, greater attention must be given to the delayed effects, especially those which do not appear until years after the transplant procedure. Children who are cured of their underlying disease continue to visit the hematologist/oncologist, but with decreasing frequency as time increases following the curative therapy, and at the same time increase the relative frequency of visits to their pediatrician...
1990: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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