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https://www.readbyqxmd.com/read/27900638/bendamustine-plus-rituximab-for-previously-untreated-patients-with-indolent-b-cell-non-hodgkin-lymphoma-or-mantle-cell-lymphoma-a-multicenter-phase-ii-clinical-trial-in-japan
#1
Michinori Ogura, Kenichi Ishizawa, Dai Maruyama, Naokuni Uike, Kiyoshi Ando, Koji Izutsu, Yasuhito Terui, Yoshitaka Imaizumi, Kunihiro Tsukasaki, Kenshi Suzuki, Tohru Izumi, Kensuke Usuki, Tomohiro Kinoshita, Masafumi Taniwaki, Nobuhiko Uoshima, Junji Suzumiya, Mitsutoshi Kurosawa, Hirokazu Nagai, Toshiki Uchida, Noriko Fukuhara, Ilseung Choi, Ken Ohmachi, Go Yamamoto, Kensei Tobinai
A Phase II, multicenter clinical trial of bendamustine plus rituximab (BR) regimen was conducted in previously untreated patients with high-tumor-burden indolent B-cell non-Hodgkin lymphoma (B-NHL) and previously untreated elderly patients with mantle cell lymphoma (MCL) in Japan. Bendamustine 90 mg/m(2)/day on days 1 and 2, as well as rituximab 375 mg/m(2) on day 1 were administered intravenously up to six cycles. The primary endpoint was the complete response (CR) rate as assessed by the International Workshop Response Criteria (1999)...
November 29, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27872740/follicular-lymphoma-a-clinicopathological-analysis-from-a-tertiary-care-institute-in-southern-india
#2
Mary Theresa Sylvia, Biswajit Dey, Debdatta Basu, Sajini Elizabeth Jacob, Rakhee Kar, Biswajit Dubashi
INTRODUCTION: Follicular lymphoma (FL) is an indolent lymphoproliferative disorder of B-cells with variable clinical behavior. It is the second most common subtype of Non-Hodgkin lymphoma in western countries but reported to have a lower incidence in Asia. MATERIALS AND METHODS: Cases of FL diagnosed in the Department of Pathology of our Institute from January 2009 to June 2015 were included in the study. The clinicopathological parameters including staging, histological details, and immunohistochemical markers CD20, CD10 and BCL-2 were recorded in all the cases...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27697981/high-body-mass-index-in-elderly-patients-with-dlbcl-treated-with-rituximab-containing-therapy-compensates-for-negative-impact-of-male-sex
#3
Zheng Zhou, Alfred W Rademaker, Leo I Gordon, Ann S LaCasce, Allison Crosby-Thompson, Ann Vanderplas, Gregory A Abel, Maria A Rodriguez, Auayporn Nademanee, Mark S Kaminski, Myron S Czuczman, Michael M Millenson, Andrew D Zelenetz, Joyce Niland, Jonathan W Friedberg, Jane N Winter
BACKGROUND: The impact of patient body habitus and sex on outcomes in diffuse large B-cell lymphoma (DLBCL) remains controversial. We investigated the impact of body mass index (BMI), body surface area (BSA), age, and sex on clinical outcomes in patients with DLBCL treated in the rituximab era. PATIENTS AND METHODS: Patients with de novo DLBCL (n=1,386) diagnosed between June 2000 and December 2010 treated with rituximab-containing chemotherapy were identified from the NCCN Oncology Outcomes Database for Non-Hodgkin's Lymphoma...
October 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27644223/mitral-valve-repair-facilitated-with-transapical-beating-heart-neochord-implantation-in-a-non-hodgkin-s-lymphoma-patient
#4
Ali Sait Kavakli, Raif Umut Ayoglu, Nilgun Kavrut Ozturk, Omer Haldun Tekinalp, Zehra Erkal, Kerem Inanoglu, Mustafa Emmiler
Elderly patients with severe hematological malignancies may require cardiac surgery. The combined impact of cardiopulmonary bypass (CPB) and surgical trauma is a potent inflammatory activator and is increased by intraoperative and postoperative complications. To avoid the adverse effects of CPB, minimally invasive off-pump techniques may be used in these patients. The transapical off-pump mitral valve intervention with NeoChord implantation (TOP-MINI) is a minimally invasive technique for mitral valve repair, which makes it possible to avoid the risks of CPB in selected patients, such as elderly, cancer or immunosuppressive patients...
September 19, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27614527/-radiotherapy-in-localized-stages-of-follicular-and-diffuse-non-hodgkin-s-lymphomas
#5
C Demoor-Goldschmidt, P Agape, I Barillot, M A Mahé
Treatment with monoclonal antibodies, especially rituximab, is more and more frequent and questions the interest of radiotherapy in limited stages of diffuse B-cell large cell and follicular non-Hodgkin's lymphomas. From a review of literature, it appears that radiotherapy is of interest in bulky disease, patients with incomplete metabolic response, elderly patients receiving short chemotherapy and those with recurrence after exclusive chemotherapy. Finally, this article gives recommendations on available techniques of radiotherapy and doses to be delivered...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27590841/high-rate-of-hepatitis-b-viral-breakthrough-in-elderly-non-hodgkin-lymphomas-patients-treated-with-rituximab-based-chemotherapy
#6
Roberto Castelli, Laurenzia Ferraris, Giuseppe Pantaleo, Giorgio Lambertenghi Deliliers, Marco Cicardi
BACKGROUND: Rituximab-containing chemotherapies are offered to elderlies for treatment of non-Hodgkin lymphomas (NHL). From 0.7 to 27% of patients with "resolved" HBV infection develop HBV reactivation and related hepatitis during Rituximab-containing chemotherapies. Currently, several antiviral drugs are available for the prophylaxis of patients at risk for HBV reactivation, which include lamivudine, tenofovir, entecavir, and adefovir. Viral breakthrough may occur during therapy, which is defined as an abrupt increase in serum HBV DNA levels after a period of persistent suppression...
August 20, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27486587/a-rare-case-of-the-upper-extremity-diffuse-large-b-cell-lymphoma-mimicking-soft-tissue-sarcoma-in-an-elderly-patient
#7
Aleksandra Mamorska-Dyga, Faisal M H Ronny, Carmelo Puccio, Humayun Islam, Delong Liu
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, with about 30% of new cases presenting with extranodal disease. Lesions originating from soft tissues of the upper extremities are extremely rare and may mimic other malignancies like sarcoma. We present a case of an elderly patient with right upper extremity (RUE) mass which was proven to be DLBCL instead of sarcoma. We emphasize the increasing need for investigating new therapeutic options for patients of extreme age and/or with underlying heart disease...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/27413523/bendamustine-and-rituximab-as-first-line-treatment-in-intermediate-high-risk-splenic-marginal-zone-lymphomas-of-elderly-patients
#8
Roberto Castelli, Antonio Gidaro, Giorgio Lambertenghi Deliliers
BACKGROUND: Splenic marginal zone lymphoma (SMZL) is a chronic B-cell lymphoproliferative disorder, comprising less than 2% of non-Hodgkin's lymphomas, and affecting mainly middle-aged and elderly patients with a median survival of >10 years. The typical clinical features of SMZL include splenomegaly. Treatment should be patient-tailored and can range from a 'watchful waiting' approach for asymptomatic patients without cytopenias to surgery, localized radiation therapy or immuno/chemotherapies...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27365955/incidence-histopathology-and-surgical-outcome-of-tumors-of-spinal-cord-nerve-roots-meninges-and-vertebral-column-data-based-on-single-institutional-sher-i-kashmir-institute-of-medical-sciences-experience
#9
Abdul Rashid Bhat, Altaf Rehman Kirmani, Muhammed Afzal Wani, Mohammed Haneef Bhat
CONTEXT: In the absence of a community-based study on the spinal tumors in the Valley, medical records of the only Regional Neurosurgical Center are available. AIM: The aim of this study is to establish a hospital-based regional epidemiology of spinal tumors in the Valley since the data are derived from a single institution. MATERIALS AND METHODS: A retrospective analysis of 531 malignant and nonmalignant tumors of spinal cord, its coverings and vertebrae, which were managed in a Regional Neurosurgical Center under a standard and uniform medical-protocol over 30-year period from 1983 to 2014...
July 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/27334857/retrospective-analysis-of-treatment-outcomes-and-geriatric-assessment-in-elderly-malignant-lymphoma-patients
#10
Yoshiko Naito, Hidenori Sasaki, Yasushi Takamatsu, Fumiaki Kiyomi, Kazuo Tamura
In recent years, the Comprehensive Geriatric Assessment (CGA), which is used in gerontology to assess functioning in elderly individuals, has been said to be useful in geriatric oncology. Therefore, we examined whether items in the CGA were associated with survival time in elderly patients with non-Hodgkin lymphoma (NHL). We conducted the CGA for 93 patients aged ≥ 65 years who had undergone treatment for NHL retrospectively. The CGA includes activities of daily living, instrumental activities of daily living, mood, cognition, nutrition, and the Charlson comorbidity index...
2016: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/27289334/cancer-and-inflammatory-bowel-disease-in-the-elderly
#11
REVIEW
Sasha Taleban, Emad Elquza, Corinne Gower-Rousseau, Laurent Peyrin-Biroulet
Cancer may be a complication of inflammatory bowel disease (IBD) or its treatments. In older Crohn's disease and ulcerative colitis patients, the risk of malignancy is of particular concern. IBD diagnosis at an advanced age is associated with earlier development of colitis-associated colorectal cancer. Thiopurine use in older IBD patients is tied to an increased risk of non-Hodgkin's lymphoma, nonmelanoma skin cancer, and urinary tract cancers. Additionally, older age is accompanied by multimorbidity, an increased risk of malnutrition, and decreased life expectancy, factors that complicate the management of cancer in the elderly...
October 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27283030/human-herpesvirus-8-unrelated-primary-effusion-lymphoma-like-lymphoma-pel-ll-in-an-elderly-korean-patient-with-a-good-response-to-rituximab-plus-cyclophosphamide-doxorubicin-vincristine-and-prednisolone
#12
Junghoon Shin, Jeong-Ok Lee, Ji-Young Choe, Soo-Mee Bang, Jong-Seok Lee
Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin's lymphoma (NHL) arising from a B-cell lineage characterized by the formation of malignant effusion in body cavities without evidence of a detectable tumor. The effusion contains tumor cells universally infected with human herpesvirus 8 (HHV8), which is the critical factor differentiating PEL from HHV8-unrelated PEL-like lymphoma (PEL-LL). This report describes a 77-year-old male patient with pleural effusion and ascites, containing lymphoma cells expressing a B-cell phenotype, but without markers of HHV8 in immunocytochemical analysis...
June 10, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27279690/a-rare-cytological-diagnosis-of-primary-non-hodgkin-lymphoma-of-the-parotid-gland
#13
Biswajit Dey, Vasudha Goyal, Jyotsna Naresh Bharti, Nidhi Mahajan, Shyama Jain
Primary lymphoma of the parotid gland is relatively rare and constitutes about 4-5% of extranodal lymphomas. The majority of them is non-Hodgkin lymphoma (NHL) and is B cell in nature. We report a case of primary diffuse large B-cell lymphoma (DLBCL) of the parotid gland in an elderly male. The case was diagnosed on fine needle aspiration cytology (FNAC) of the right parotid gland as high grade B-cell NHL and confirmed on histopathology as DLBCL. In correlation with the clinicoradiological findings, the case was diagnosed as primary parotid DLBCL...
April 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27159512/an-abundance-of-polyps-an-intriguing-case-of-lymphomatous-polyposis
#14
Courtney Fox, Teja Poosarla, Kamal Mandalapu, H David Vargas, Marc R Matrana
Multiple lymphomatous polyposis (MLP) is a rare condition in which non-Hodgkin lymphoma (NHL), typically mantle cell lymphoma, presents as multiple mucosal polyps of the intestine. We present the case of a 66-year-old man who presented with newly acquired polyps throughout the colon, detected by endoscopy. Endoscopic biopsies confirmed the diagnosis of mantle cell lymphoma. The patient underwent treatment on a research protocol. Our case illustrates the importance of considering MLP or other forms of NHL in elderly patients found to have multiple gastrointestinal polyps, especially those who have a history of clear colonoscopy within the previous one to two years...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27138539/an-abundance-of-polyps-an-intriguing-case-of-lymphomatous-polyposis
#15
Courtney Fox, Teja Poosarla Md, Kamal Mandalapu Md, H David Vargas Md, Marc R Matrana Md
Multiple lymphomatous polyposis (MLP) is a rare condition in which non-Hodgkin lymphoma (NHL), typically mantle cell lymphoma, presents as multiple mucosal polyps of the intestine. We present the case of a 66-year-old man who presented with newly acquired polyps throughout the colon, detected by endoscopy. Endoscopic biopsies confirmed the diagnosis of mantle cell lymphoma. The patient underwent treatment on a research protocol. Our case illustrates the importance of considering MLP or other forms of NHL in elderly patients found to have multiple gastrointestinal polyps, especially those who have a history of clear colonoscopy within the previous one to two years...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27093518/a-retrospective-analysis-of-combination-chemotherapy-consisting-cyclophosphamide-vincristine-prednisolone-and-procarbazine-c-mopp-for-pretreated-aggressive-non-hodgkin-lymphoma
#16
Ryoko Fukushima, Yukio Kobayashi, Suguru Fukuhara, Ken'ichi Miyamoto, Wataru Munakata, Dai Maruyama, Sung-Won Kim, Takashi Watanabe, Hirokazu Taniguchi, Akiko Maeshima, Kensei Tobinai
The C-MOPP regimen, consisting cyclophosphamide, vincristine, prednisolone and procarbazine, has been used for treatment of non-Hodgkin lymphoma; however, there are few reports of this therapy against aggressive lymphoma. We performed a retrospective analysis of previously treated 89 patients who had received C-MOPP therapy from 1999 to 2013 at our institution. Median age was 67 (range, 22-81) years. Twenty-eight patients obtained CR, 5 obtained PR, and overall response rate was 37% (33/89). The estimated 1-year overall survival and progression-free survival rates were 61 and 33%, respectively...
April 2016: Journal of Chemotherapy
https://www.readbyqxmd.com/read/27011653/laryngeal-carcinoma-presenting-as-polymyositis-a-paraneoplastic-syndrome
#17
Ritesh Sahu, Bhanu Pratap Rathaur, Tejendra Sukdeo Chaudhari, Rakesh Shukla, Kiran Preet Malhotra
Laryngeal carcinoma is rarely associated with paraneoplastic syndrome. Inflammatory myopathy presenting as paraneoplastic event is commonly associated with carcinomas of ovary, lung, pancreas, stomach, colorectal, and non-Hodgkin's lymphoma. We report a case of elderly male, who presented with proximal muscle weakness and found to be associated with laryngeal carcinoma. Diagnosis of polymyositis (PM) was confirmed based on clinical features, laboratory test, and muscle biopsy. Exclusion of other commonly associated malignancies was done...
January 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/26960470/retrospective-audit-of-clinico-pathologic-features-and-treatment-outcomes-in-a-cohort-of-elderly-non-hodgkin-s-lymphoma-patients-in-a-tertiary-cancer-center
#18
C K Nair, V M Patil, V Raghavan, S Babu, S Nayanar
INTRODUCTION: There is limited data from India regarding elderly non-Hodgkin's lymphomas (NHL) patients. Hence, this audit was planned to study the clinic-pathological features and treatment outcomes in elderly NHL patients. METHODS: Retrospective analysis of all NHL patients above age of 59 years treated at the author's institute, between December 2010 and December 2013 was done. Case records were reviewed for baseline details, staging details, prognostic factors, treatment delivered, response, toxicity and efficacy...
October 2015: Indian Journal of Cancer
https://www.readbyqxmd.com/read/26950314/cancer-risk-among-the-hiv-infected-elderly-in-the-united-states
#19
Elizabeth L Yanik, Hormuzd A Katki, Eric A Engels
OBJECTIVE: HIV-infected people and elderly people have higher cancer risk, but the combined effects of aging and HIV are not well described. We aimed to evaluate the magnitude of cancer risk in the HIV-infected elderly population. DESIGN: We conducted a case-cohort study including a 5% sample of U.S. Medicare enrollees and all cancer cases aged at least 65 in linked cancer registries. METHODS: HIV was identified through Medicare claims. Among the HIV-infected, absolute cancer risk was calculated accounting for the competing risk of death...
June 19, 2016: AIDS
https://www.readbyqxmd.com/read/26891973/conjunctival-lymphoma-an-international-multicenter-retrospective-study
#20
MULTICENTER STUDY
Marina M Kirkegaard, Peter K Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Santosh G Honavar, Jwu J Khong, Penny A McKelvie, Kaustubh Mulay, Jan U Prause, Elisabeth Ralfkiaer, Lene D Sjö, Peter B Toft, Geeta K Vemuganti, Bradley A Thuro, Jeremy Curtin, Steffen Heegaard
IMPORTANCE: To date, the clinical features of the various subtypes of conjunctival lymphoma (CL) have not been previously evaluated in a large cohort. OBJECTIVE: To characterize subtype-specific clinical features of CL and their effect on patient outcome. DESIGN, SETTING, AND PARTICIPANTS: A retrospective multicenter study was performed. Patient data were collected from January 1, 1980, through December 31, 2010. The dates of the analysis were May 15, 2015, to August 20, 2015...
April 2016: JAMA Ophthalmology
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