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https://www.readbyqxmd.com/read/24042208/hypoxic-hepatitis-and-acute-liver-failure-in-a-patient-with-newly-onset-atrial-fibrillation-and-diltiazem-infusion
#1
Wu Deng, Laurie Farricielli
Hypoxic hepatitis (HH) most commonly results from haemodynamic instability and disruption of hepatic flow. The vast majority of cases are caused by cardiac failure, respiratory failure and septic shock. We report a case of HH, acute liver failure, acute kidney failure and progressive thrombocytopenia that developed following a hypotensive episode in a patient treated with intravenous diltiazem for a newly developed atrial fibrillation (A-fib). The pre-existing liver diseases, including chronic alcohol use and liver congestion secondary to right heart dysfunction, might have predisposed the patient to the development of HH...
September 16, 2013: BMJ Case Reports
https://www.readbyqxmd.com/read/9633717/persistent-inflammatory-response-in-stroke-survivors
#2
N B Beamer, B M Coull, W M Clark, D P Briley, M Wynn, G Sexton
OBJECTIVE: Goals were to determine how long acute-phase markers remain elevated after ischemic stroke and how marker levels relate to stroke risk factors, stroke mechanism, and subsequent vascular events. METHODS: Fibrinogen (FIB), C-reactive protein (CRP), leukocytes (WBC), neutrophils (PMN), interleukin-6, and interleukin-1 receptor antagonist were measured at stroke onset and at 6 weeks, 6 months, and 1 year after enrollment, or until a vascular event occurred in 136 acute ischemic stroke patients, 76 patients with comparable risk factors for stroke, and 48 age-balanced healthy subjects...
June 1998: Neurology
https://www.readbyqxmd.com/read/7882493/enalapril-treatment-increases-cardiac-performance-and-energy-reserve-via-the-creatine-kinase-reaction-in-myocardium-of-syrian-myopathic-hamsters-with-advanced-heart-failure
#3
L Nascimben, J Friedrich, R Liao, P Pauletto, A C Pessina, J S Ingwall
BACKGROUND: Converting enzyme inhibitor treatment of congestive heart failure slows progression to failure and reduces mortality rate. It is known whether these benefits are due solely to improved hemodynamics or also to improved myocyte energetics. This study examines the effect of enalapril treatment on both isovolumic contractile performance and its biochemical correlate, flux through the creatine kinase (CK) system, in an animal model of severely failing myocardium. METHODS AND RESULTS: Seven-month-old Syrian cardiomyopathic (TO-2 strain) and normal golden Syrian (FIB strain) hamsters were each randomly assigned to one of three groups supplied daily with either no, low (25 mg/kg body wt), or high (100 mg/kg body wt) doses of enalapril for 12 to 14 weeks...
March 15, 1995: Circulation
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