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https://www.readbyqxmd.com/read/29925104/right-tkr-patients-treated-with-enhanced-pain-and-rehabilitation-protocols-can-drive-at-2-weeks
#1
David F Dalury, Danielle M Chapman
An important milestone in the recovery following total knee replacement (TKR) is the ability to return to driving. With advances in pain control and the widespread introduction of rapid rehab programs, we hypothesized that the ability to drive would also return sooner than had been traditionally observed. In our group of consecutive right TKR patients, using a driving simulator, we showed that at the 2-week mark, 36 of the 40 patients tested had returned to their preoperative driving capabilities and the other 4 had reached baseline at 3 weeks...
June 20, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29925074/a-retrospective-study-of-letrozole-treatment-prior-to-human-chorionic-gonadotropin-in-women-with-polycystic-ovary-syndrome-undergoing-in-vitro-fertilization-at-risk-of-ovarian-hyperstimulation-syndrome
#2
Yilu Chen, Tanchu Yang, Cuifang Hao, Junzhao Zhao
BACKGROUND Women with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) are given letrozole before a trigger injection of human chorionic gonadotropin (hCG) to lower estrogen (E2) levels, but can experience ovarian hyperstimulation syndrome (OHSS). The aim of this study was to evaluate the effect of oral letrozole, prior to administration of hCG, on the outcome of IVF and development of OHSS. MATERIAL AND METHODS Retrospective clinical review included 181 cases of women with PCOS who underwent IVF cycles with intracytoplasmic sperm injection (ICSI) and embryo transfer (ET) (IVF/ICSI-ET)...
June 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29925032/transition-from-actin-driven-to-water-driven-cell-migration-depends-on-external-hydraulic-resistance
#3
Yizeng Li, Sean X Sun
Cells in vivo can reside in diverse physical and biochemical environments. For example, epithelial cells typically live in a two-dimensional (2D) environment, whereas metastatic cancer cells can move through dense three-dimensional matrices. These distinct environments impose different kinds of mechanical forces on cells and thus potentially can influence the mechanism of cell migration. For example, cell movement on 2D flat surfaces is mostly driven by forces from focal adhesion and actin polymerization, whereas in confined geometries, it can be driven by water permeation...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29924958/overexpression-of-mir-361-5p-in-triple-negative-breast-cancer-tnbc-inhibits-migration-and-invasion-by-targeting-rqcd1-and-inhibiting-the-egfr-pi3k-akt-pathway
#4
Jianjun Han, Jingjing Yu, Yuna Dai, Jumei Li, Meiyan Guo, Jingzhen Song, Xuefeng Zhou
Triple-negative breast cancer (TNBC) is the leading cause of cancer-related death in women. Previous studies indicated that miR-361-5p was downregulated in breast cancer, however, the exact effect of miR-361-5p on TNBC requires further investigation. In the present study, we investigated whether miR-361-5p can act as a tumor suppressor by targeting required for cell differentiation 1 homolog (RQCD1) and inhibiting epidermal growth factor receptor (EGFR)/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway in TNBC...
June 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29924856/a-g542x-cystic-fibrosis-mouse-model-for-examining-nonsense-mutation-directed-therapies
#5
Daniel R McHugh, Miarasa S Steele, Dana M Valerio, Alexander Miron, Rachel J Mann, David F LePage, Ronald A Conlon, Calvin U Cotton, Mitchell L Drumm, Craig A Hodges
Nonsense mutations are present in 10% of patients with CF, produce a premature termination codon in CFTR mRNA causing early termination of translation, and lead to lack of CFTR function. There are no currently available animal models which contain a nonsense mutation in the endogenous Cftr locus that can be utilized to test nonsense mutation therapies. In this study, we create a CF mouse model carrying the G542X nonsense mutation in Cftr using CRISPR/Cas9 gene editing. The G542X mouse model has reduced Cftr mRNA levels, demonstrates absence of CFTR function, and displays characteristic manifestations of CF mice such as reduced growth and intestinal obstruction...
2018: PloS One
https://www.readbyqxmd.com/read/29924769/randomized-double-blind-study-comparing-percutaneous-electrolysis-and-dry-needling-for-the-management-of-temporomandibular-myofascial-pain
#6
R Lopez-Martos, L-M Gonzalez-Perez, P Ruiz-Canela-Mendez, F-J Urresti-Lopez, J-L Gutierrez-Perez, P Infante-Cossio
BACKGROUND: To assess whether the techniques of percutaneous needle electrolysis (PNE) and deep dry needling (DDN) used on trigger points (TrP) of lateral pterygoid muscle (LPM) can significantly reduce pain and improve function in patients with myofascial pain syndrome (MPS) compared to a control group treated with a sham needling procedure (SNP). MATERIAL AND METHODS: Sixty patients diagnosed with MPS in the LPM were selected and randomly assigned to one of three groups...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29924727/the-role-of-acid-sphingomyelinase-and-modulation-of-sphingolipid-metabolism-in-bacterial-infection
#7
Alexander Simonis, Alexandra Schubert-Unkmeir
Acid sphingomyelinase (ASM) is a key enzyme in sphingolipid metabolism that converts sphingomyelin to ceramide, thereby modulating membrane structures and signal transduction. Bacterial pathogens can manipulate ASM activity and function, and use host sphingolipids during multiple steps of their infection process. An increase in ceramides upon infection results in the formation of ceramide-enriched membrane platforms that serve to cluster receptor molecules and organize intracellular signaling molecules, thus facilitating bacterial uptake...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29924722/interaction-of-volatile-organic-compounds-and-underlying-liver-disease-a-new-paradigm-for-risk
#8
Anna L Lang, Juliane I Beier
Occupational and environmental exposures to industrial chemicals are known to cause hepatotoxicity and liver injury, in humans and in animal models. Historically, research has focused on severe acute liver injury (e.g., fulminant liver failure) or endstage diseases (e.g., cirrhosis and HCC). However, it has become recently recognized that toxicants can cause more subtle changes to the liver. For example, toxicant-associated steatohepatitis (TASH), characterized by hepatic steatosis, and inflammation, was recently recognized in an occupational cohort exposed to vinyl chloride...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29924681/identifying-and-understanding-the-gaps-in-care-experienced-by-adolescent-and-young-adult-cancer-patients-at-the-university-of-iowa-hospitals-and-clinics
#9
Erin M Mobley, Kristin J Foster, William W Terry
PURPOSE: In an effort to counteract the differences in improvement in survival rates of adolescents and young adults (AYA), compared to other age groups with cancer, the University of Iowa Hospitals and Clinics established an AYA cancer program. This study was conducted to gather feedback from AYAs in an effort to generate actionable data for program development. METHODS: The target population included patients aged 13-31 treated for malignancy in one of the following disease sites: central nervous system, leukemia, lymphoma, neuroendocrine, sarcoma, and thyroid...
June 20, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29924632/heat-shock-protein-72-regulates-hepatic-lipid-accumulation
#10
Ashley E Archer, Robert S Rogers, Alex T Von Schulze, Joshua L Wheatley, E Matthew Morris, Colin S McCoin, John P Thyfault, Paige C Geiger
Induction of the chaperone Heat Shock Protein 72 (HSP72) through heat treatment, exercise, or overexpression improves glucose tolerance and mitochondrial function in skeletal muscle. Less is known about HSP72 function in the liver where lipid accumulation can result in insulin resistance and Nonalcoholic Fatty Liver Disease (NAFLD). The purpose of this study was 1) to determine whether weekly in vivo heat treatment (HT) induces hepatic HSP72 and improves glucose tolerance in rats fed a high-fat diet (HFD) and 2) to determine the ability of HSP72 to protect against lipid accumulation and mitochondrial dysfunction in primary hepatocytes...
June 20, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29924603/total-stereo-selective-michael-addition-of-n-and-s-nucleophiles-to-a-d-erythrosyl-1-5-lactone-derivative-experimental-and-theoretical-studies-devoted-to-the-synthesis-of-2-6-dideoxy-4-functionalized-d-ribono-hexono-1-4-lactone
#11
Juliana F Rocha, David S Freitas, Jennifer Noro, Carla Sílvia Silva Teixeira, Cristina E A Sousa, M Jose Alves, Nuno M F Sousa A Cerqueira
The synthesis of a 1,5-lactone 2,4-O-alkylidene-D-erythrose derivative was found to be a highly stereoselective template in Michael addition trough the reaction of a D-erythrosyl 1,5-lactone derivative with nitrogen and sulfur nucleophiles. The sulfur adducts formed are 1 (D-erythrose derivative):1 (nucleophile), and the nitrogen adducts are 1:2. Both were then treated under HCl to give 2,6-dideoxy-4-functionalized-D-ribono-hexono-1,4-lactone by a reaction cascade in high overall yield. Reaction's scale up even improves the yield...
June 20, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29924454/prognostic-impact-of-doublecortin-like-kinase-1-expression-in-locally-advanced-rectal-cancer-treated-with-preoperative-chemoradiotherapy
#12
Yuzo Harada, Shinsuke Kazama, Teppei Morikawa, Shigenobu Emoto, Koji Murono, Manabu Kaneko, Kazuhito Sasaki, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Keisuke Hata, Hiroaki Nozawa, Soichiro Ishihara, Toshiaki Watanabe
Preoperative chemoradiotherapy (CRT) is a standard therapy for locally advanced rectal cancer; however, the response varies depending on cases. Therefore, CRT-response predictors need to be elucidated. Cancer stem cells (CSCs), comprising a small part of tumors, are associated with tumor progression and recurrence due to their self-renewal and proliferation abilities. Doublecortin-like kinase 1 (DCLK1) is one of the several putative CSC markers; however, the clinical impact of its expression in rectal cancer has not been evaluated...
June 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29924256/multidrug-resistant-tuberculosis-in-the-end-tuberculosis-eramultidrug-resistant-tuberculosis-in-the-end-tuberculosis-era
#13
J Peter Cegielski
Multidrug-resistant (MDR) tuberculosis (TB) emerged shortly after introduction of rifamycins in the 1960s; isoniazid resistance had already emerged by the mid-1950s. Without these two drugs, tuberculosis is very difficult and costly to treat, with unacceptably high rates of treatment failure, death, loss to follow-up, and no known preventive treatment. Global attention first focused on MDR TB in the early 1990s when nosocomial outbreaks with high case fatality rates were reported in many countries. Prevalence data for MDR TB on a global scale first became available in 1997...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29924242/treatment-of-cutaneous-leishmaniasis-with-thermotherapy-in-brazil-an-efficacy-and-safety-study
#14
Sheila Viana Castelo Branco Gonçalves, Carlos Henrique Nery Costa
BACKGROUND: Pentavalent antimonials remain as the standard drugs in the treatment of cutaneous leishmaniosis. The high cost, difficult administration, long treatment time, toxicity and increasing morbidity are factors that limit the use of these drugs. OBJECTIVES: To describe the response to radiofrequency thermotherapy in the treatment of localized cutaneous leishmaniasis in Brazil, and to evaluate its safety and tolerability. METHODS: We conducted a non-comparative open trial with a total of 15 patients confirmed to have cutaneous leishmaniasis on parasitological examination...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924232/analysis-of-patients-diagnosed-with-primary-cutaneous-melanoma-in-the-last-six-years-in-hospital-erasto-gaertner-epidemiologic-profile
#15
Tariane Friedrich Foiato, Bruno Rafael Kunz Bereza, Marcos Flávio Montenegro, Marina Riedi Guilherme, Larissa Beatriz Volski, Juliano Camargo Rebolho
BACKGROUND: Melanoma is one of the conditions with greater increase in incidence worldwide in recent decades. It is a skin cancer with potential high lethality and predominates in Caucasian adults. Treatment of primary cutaneous melanoma is essentially surgical and search for sentinel lymph node can modify the aggressiveness of the treatment. OBJECTIVE: To analyze the epidemiological profile of patients diagnosed with primary cutaneous melanoma, histopathological features and compare with literature data...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924228/exuberant-case-of-cutaneous-metastasis-of-breast-cancer
#16
Vítor Angelo Ferreira, Karla Spelta, Lucia Martins Diniz, Elton Almeida Lucas
Cutaneous metastasis is the main cause of morbidity and mortality of cancer patients, denoting a guarded prognosis. The clinical spectrum of the disease is broad and can mimic benign conditions. The diagnosis depends on thorough clinical examination and complementary exams, with emphasis on the histopathological study and immunohistochemistry. Because it indicates a systemic relapse, it is necessary to intervene with intravenous chemotherapy, to which local therapies can be associated. We report the case of a 65-year-old woman with cutaneous metastasis from breast cancer treated 14 years back, manifested by extensive firm and infiltrated red-purple plaques on the sides of the trunk, with a course of six months...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924043/conservative-management-of-acute-calculous-cholecystitis-complicated-by-pancreatitis-in-an-elderly-woman-a-case-report
#17
Marta K Walczak-Galezewska, Damian Skrypnik, Monika Szulinska, Katarzyna Skrypnik, Pawel Bogdanski
RATIONALE: Acute calculous cholecystitis is a prevalent disease whose diagnosis and management still face significant debate. Although the overall incidence of gallstone disease is 18.8% in European women aged 30 to 69 years, there is little data and experience in managing acute calculous cholecystitis in populations over 80 years old. The incidence of acute cholecystitis among the elderly is probably increasing. For the reason, we here highlight the advantages and disadvantage of various treatment and management opens based on a 96-year-old patient...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924031/unexpected-and-durable-response-with-regorafenib-in-a-metastatic-colorectal-cancer-patient-without-kdr-mutation-a-case-report
#18
Gerardo Rosati, Nunzio Del Gaudio, Enrico Scarano, Rosa Anna Cifarelli, Lucia Altucci, Domenico Bilancia
RATIONALE: Regorafenib is an oral multikinase inhibitor and is approved as salvage therapy in the standard treatment of advanced colorectal cancer (CRC). Due to its limited efficacy, toxicity profile, and cost, it is necessary to identify those patients who may have the most benefit from regorafenib. In a previous case report, kinase insert domain receptor (KDR) mutation has been associated with exceptional clinical response (CR) in an elderly patient treated with a low dose of regorafenib; thus, it was hypothesized that it could represent a new predictive marker of drug response...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924019/case-report-successful-treatment-of-refractory-sapho-syndrome-with-the-jak-inhibitor-tofacitinib
#19
Qiao Yang, Yumo Zhao, Chen Li, Yaping Luo, Weixin Hao, Wen Zhang
INTRODUCTION: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an autoinflammatory disorder without standardized treatment. Janus kinase (JAK) inhibitors can block a range of cytokines and might possess significant anti-inflammatory activity. Here, we report the first case of efficacious treatment of refractory SAPHO syndrome with the JAK inhibitor tofacitinib. CASE PRESENTATION: A 44-year-old woman presented with arthralgia in the right wrist and complained of having difficulty in doing housework...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923981/abrupt-hemodynamic-changes-accompanying-intrapleural-hyperthermic-chemotherapy-case-series
#20
Hyae-Jin Kim, Hyeon-Jeong Lee, Eunsoo Kim, Jihwan Yun
RATIONALE: Intrapleural hyperthermic chemotherapy (IPHC) is the preferred method to locally treat lung cancer with pleural seeding. Anesthetic management during IPHC is a very challenging task for the anesthesiologist because of the hemodynamic instability associated with the procedure; however, there is no report on anesthetic considerations during the IPHC procedure. PATIENT CONCERNS: Three patients who diagnosed lung cancer with pleural invasion scheduled for IPHC were reported in this case series...
June 2018: Medicine (Baltimore)
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