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https://www.readbyqxmd.com/read/29245171/effects-of-atorvastatin-on-autophagy-in-skeletal-muscles-of-diabetic-rats
#1
Bingquan Yang, Jie Sun, Yang Yuan, Zilin Sun
AIMS/INTRODUCTION: Atorvastatin is usually used to decrease the amount of fatty substances in individuals with type 2 diabetes mellitus. However, it can cause side effects, such as breakdown of skeletal muscle tissue. This study focuses on the effects of atorvastatin on autophagy of the skeletal muscles in diabetic rats. MATERIALS AND METHODS: Diabetes in rats in the diabetic (D) and atorvastatin (T) groups was induced using streptozotocin (65 mg/kg, intraperitoneal injection)...
December 15, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29245107/impacts-on-the-seagrass-zostera-nigricaulis-from-the-herbicide-fusilade-forte%C3%A2-used-in-the-management-of-spartina-anglica-infestations
#2
Megan Carve, Timothy L Coggan, Jackie H Myers, Bradley Clarke, Dayanthi Nugegoda, Jeff Shimeta
The herbicide Fusilade Forte® (FF) is widely applied in agricultural weed management and in the management of the invasive saltmarsh grass, Spartina anglica (ricegrass or cordgrass). FF (active ingredient fluazifop-P acid, FPA) is selective for poaceous grasses. Its primary mode of action is inhibition of the acetyl coenzyme-A carboxylase (ACCase) specific to this taxonomic group, and its secondary mode is by promotion of oxidative stress. FF is applied to S. anglica infestations in the intertidal zone, in proximity to seagrass meadows...
December 1, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29245106/cerebral-arterio-venous-malformations-in-the-paediatric-population-angiographic-characteristics-multimodal-treatment-strategies-and-outcome
#3
Klaus-Peter Stein, Bernd-Otto Huetter, Sophia Goericke, Neriman Oezkan, Rebecca Leyrer, I Erol Sandalcioglu, Michael Forsting, Ulrich Sure, Oliver Mueller
OBJECTIVES: Cerebral arterio-venous malformations (AVM) are considered congenital lesions, emerging as an important cause of haemorrhagic stroke in children. The potential influence of age on clinical presentation and angio-architecture have been analysed extensively in the last years. Yet, comparative studies comprising ascending age groups may be limited in their conclusions, especially when comparing young children and adults. It is the aim of this study to evaluate characteristic clinical and angiographic features of AVM within a paediatric subgroup and their correlation to age at presentation...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29245099/total-bilateral-tmj-reconstruction-for-pain-and-dysfunction-case-report
#4
Carlos Vinícius Ayres Moreira, André Victor Pinto Serra, Larissa Oliveira Ramos Silva, Ana Carolina Fraga Fernandes, Roberto Almeida de Azevedo
INTRODUCTION: Temporomandibular disorders encompass a set of clinical conditions that affect the temporomandibular joint, the masticatory muscles and the associated tissues. Many therapeutic alternatives can be considered, being divided into non-invasive, minimally invasive and invasive interventions. This work aims to report a case of inflammatory joint pain and dysfunction treated with bilateral TMJ full reconstruction with alloplastic prosthesis stock. CASE REPORT: Patient D...
December 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29245097/inverted-v-shaped-high-tibial-osteotomy-for-severe-tibia-vara-associated-with-turner-syndrome-a-case-report-and-review-of-literature
#5
Daisuke Abe, Satoshi Hamai, Ken Okazaki, Masato Yoshimoto, Takashi Komatsu, Yasuharu Nakashima
INTRODUCTION: Severe cases of genu varum represent a major challenge in obtaining normal configuration of the proximal tibia and overall limb alignment. PRESENTATION OF CASE: We performed inverted V-shaped high tibial osteotomy (HTO) by using a locking plate for recurrent severe bilateral tibia vara in a 15-year-old female patient with Turner syndrome. Preoperative medial proximal tibial angle (MPTA) and standing femorotibial angle (FTA) of the right/left legs were 67°/69° and 197°/203°, respectively...
December 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29245069/aqueous-extract-of-triphala-inhibits-cancer-cell-proliferation-through-perturbation-of-microtubule-assembly-dynamics
#6
Sanith Cheriyamundath, Tejashree Mahaddalkar, Shreyada N Save, Sinjan Choudhary, Ramakrishna V Hosur, Manu Lopus
Triphala (Trl) is an ayurvedic formulation used for treating disorders of the digestive, respiratory, and nervous systems. Its anticancer properties have also been documented. We studied effects of Trl on tubulin, a target protein for several anticancer drugs, and systematically elucidated a possible antiproliferative mechanism of action of Trl. Trl inhibited proliferation of HeLa (cervical adenocarcinoma), PANC-1 (pancreatic adenocarcinoma), and MDA-MB-231 (triple-negative breast carcinoma) cells in microgram quantities and strongly suppressed the clonogenicity of HeLa cells...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29245041/stability-of-postmortem-methemoglobin-artifactual-changes-caused-by-storage-conditions
#7
Vincent Varlet, Elenore Ryser, Marc Augsburger, Cristian Palmiere
Hemoglobin is the protein in red blood cells that carries and distributes oxygen to the body. Methemoglobinemia is a blood disorder in which an abnormal amount of methemoglobin (MetHb), a form of hemoglobin (Hb), is produced from either inadequate MetHb reductase activity or too much MetHb production or by exposure to oxidizing agents. This could lead to anoxia and death if it is not treated. However, this parameter has not been investigated as a valid post-mortem indicator because random MetHb levels have been observed in various studies: MetHb increases can be observed due to autoxidation during storage, and MetHb decreases can be observed due to MetHb reductase or microbial activity in post-mortem samples...
December 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29244998/applicability-of-the-national-comprehensive-cancer-network-multinational-association-of-supportive-care-in-cancer-guidelines-for-prevention-and-management-of-chemotherapy-induced-nausea-and-vomiting-in-southeast-asia-a-consensus-statement
#8
Alexandre Chan, Matin M Abdullah, Wan Zamaniah B Wan Ishak, Annielyn B Ong-Cornel, Antonio H Villalon, Ravindran Kanesvaran
A meeting of regional experts was convened in Manila, Philippines, to develop a resource-stratified chemotherapy-induced nausea and vomiting (CINV) management guideline. In patients treated with highly emetogenic chemotherapy in general clinical settings, triple therapy with a serotonin (5-hydroxytryptamine-3 [5-HT3]) antagonist (preferably palonosetron), dexamethasone, and aprepitant is recommended for acute CINV prevention. In resource-restricted settings, triple therapy is still recommended, although a 5-HT3 antagonist other than palonosetron may be used...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244974/the-use-of-an-antioxidant-dressing-on-hard-to-heal-wounds-a-multicentre-prospective-case-series
#9
B Castro, F D Bastida, T Segovia, P López Casanova, J J Soldevilla, J Verdú-Soriano
OBJECTIVE: Oxidative stress can contribute to impaired wound healing and chronic wounds. Our objective was to test the results of a new antioxidant dressing that could help stop the oxidative stress of cells in the wound bed. METHOD: A multicentre, prospective case study series was conducted in three Spanish hospitals. The RESVECH 2.0 index was used for healing assessment. Data from each patient was collected by the attending clinical researchers. Data analysis was performed using the statistical concept intention-to-treat (ITT)...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29244969/treatment-of-open-upper-limb-injuries-with-infection-prevention-and-negative-pressure-wound-therapy-a-systematic-review
#10
E Ali, M Raghuvanshi
OBJECTIVE: Open upper limb injuries requiring soft reconstruction can pose a dilemma for trauma surgeons when considering the treatment options. The British Orthopaedic Association and British Association of Plastic, Reconstructive and Aesthetic Surgeons Standard for Trauma (BOAST) have addressed the management of severe open lower limb fractures with the creation of the BOAST 4 guidelines. However, no such gold standard exists for the treatment of open injuries of the upper limb. Furthermore, treatment of these injuries is often more difficult and requires complicated strategies...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29244906/finding-treatment-resistant-depression-in-real-world-data-how-a-data-driven-approach-compares-with-expert-based-heuristics
#11
M Soledad Cepeda, Jenna Reps, Daniel Fife, Clair Blacketer, Paul Stang, Patrick Ryan
BACKGROUND: Depression that does not respond to antidepressants is treatment-resistant depression (TRD). TRD definitions include assessments of treatment response, dose and duration, and implementing these definitions in claims databases can be challenging. We built a data-driven TRD definition and evaluated its performance. METHODS: We included adults with depression, ≥1 antidepressant, and no diagnosis of mania, dementia, or psychosis. Subjects were stratified into those with and without proxy for TRD...
December 15, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29244843/pathology-in-repeated-transurethral-resection-of-a-bladder-tumor-as-a-risk-factor-for-prognosis-of-high-risk-non-muscle-invasive-bladder-cancer
#12
Bum Sik Tae, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Kyung Chul Moon, Ja Hyeon Ku
The prognostic value of repeat transurethral resection of bladder tumor (TURBT) in patients with diagnosed high-risk, non-muscle-invasive bladder cancer (NMIBC) was investigated. We retrospectively reviewed the medical records of patients treated from October 2004 to December 2013 at Seoul National University who underwent repeated TURBT within 2-6 weeks after an initial resection. The study enrolled patients who had been diagnosed with NMIBC at both the initial and repeat TURBT; patients with muscle-invasive tumors on repeat TURBT were excluded...
2017: PloS One
https://www.readbyqxmd.com/read/29244758/protein-subcellular-localization-with-gaussian-kernel-discriminant-analysis-and-its-kernel-parameter-selection
#13
Shunfang Wang, Bing Nie, Kun Yue, Yu Fei, Wenjia Li, Dongshu Xu
Kernel discriminant analysis (KDA) is a dimension reduction and classification algorithm based on nonlinear kernel trick, which can be novelly used to treat high-dimensional and complex biological data before undergoing classification processes such as protein subcellular localization. Kernel parameters make a great impact on the performance of the KDA model. Specifically, for KDA with the popular Gaussian kernel, to select the scale parameter is still a challenging problem. Thus, this paper introduces the KDA method and proposes a new method for Gaussian kernel parameter selection depending on the fact that the differences between reconstruction errors of edge normal samples and those of interior normal samples should be maximized for certain suitable kernel parameters...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244747/ophthalmic-formulation-containing-nilvadipine-nanoparticles-prevents-retinal-dysfunction-in-rats-injected-with-streptozotocin
#14
Saori Deguchi, Hiroko Otake, Yosuke Nakazawa, Noriko Hiramatsu, Naoki Yamamoto, Noriaki Nagai
Retinopathy leads to irreparable vision loss via capillary closure and areas of nonperfusion. However, the current instillation systems do not allow a sufficient amount of drug required to treat retinopathy to reach the posterior segment (retina); therefore, a new formulation targeting the posterior segment is expected as therapy for retinopathy. We prepared ophthalmic formulations containing nilvadipine nanoparticles (NILnano), and demonstrated whether the instillation of NILnano can prevent retinal dysfunction in rats injected with excessive streptozotocin (STZ rats) in this study...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244726/potential-of-bioactive-glasses-for-cardiac-and-pulmonary-tissue-engineering
#15
REVIEW
Saeid Kargozar, Sepideh Hamzehlou, Francesco Baino
Repair and regeneration of disorders affecting cardiac and pulmonary tissues through tissue-engineering-based approaches is currently of particular interest. On this matter, different families of bioactive glasses (BGs) have recently been given much consideration with respect to treating refractory diseases of these tissues, such as myocardial infarction. The inherent properties of BGs, including their ability to bond to hard and soft tissues, to stimulate angiogenesis, and to elicit antimicrobial effects, along with their excellent biocompatibility, support these newly proposed strategies...
December 15, 2017: Materials
https://www.readbyqxmd.com/read/29244701/reconstruction-of-a-neglected-tibial-plateau-fracture-malunion-with-an-open-book-osteotomy-a-case-report
#16
Dimitrios S Mastrokalos, Georgios N Panagopoulos, Dimitrios Koulalis, Konstantinos C Soultanis, Vasileios A Kontogeorgakos, Panayiotis J Papagelopoulos
CASE: Surgical management of tibial plateau fractures can be challenging, and complications can be devastating. We report the case of a lateral tibial plateau fracture malunion with an associated intra-articular depression, which we treated with an open-book osteotomy, obviating the need for an early corrective osteotomy or knee arthroplasty. CONCLUSION: A tibial plateau fracture malunion can be reconstructed. The surgical team should give priority to salvage options, which can obviate or delay the need for and the implications of an early total knee arthroplasty, especially in a young and active patient...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244683/insufficiency-fracture-occurring-3-years-after-union-of-an-intertrochanteric-hip-fracture-a-case-report
#17
Byung-Ho Yoon, Sung Bae Park
CASE: We present a rare case of insufficiency fracture at the level of the distal interlocking screw following union of an intertrochanteric hip fracture. A 74-year-old woman reported chronic thigh pain for 1 month. She had a history of an osteoporotic stable intertrochanteric fracture that was successfully treated with a short intramedullary nail 3.5 years prior. However, after union, the neck-shaft angle of the femur changed from 125° to 117°. She had been on alendronic acid therapy to prevent a secondary osteoporotic fracture...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244663/scapular-winging-caused-by-combined-palsy-of-the-spinal-accessory-nerve-and-the-long-thoracic-nerve-a-case-report
#18
Kentaro Ago, Noboru Matsumura, Takuji Iwamoto, Kazuki Sato, Masaya Nakamura, Morio Matsumoto
CASE: A 37-year-old man with scapular winging, caused by combined palsy of the spinal accessory nerve and the long thoracic nerve, was successfully treated with a pectoralis major transfer to substitute for the serratus anterior muscle, and with levator scapulae and rhomboid muscle transfers to substitute for the trapezius muscle. CONCLUSION: The serratus anterior paralysis was thought to have occurred secondary to traction of the long thoracic nerve by the unsupported scapula following the spinal accessory nerve palsy...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244655/duplex-imprinted-nano-well-arrays-for-promising-nanoparticles-assembly
#19
Xiangping Li, Andreas Manz
A large area nano-duplex-imprint technique is presented in this contribution using natural cicada wings as stamp. The glassy wings of the cicada, which are abundant in nature, exhibit strikingly interesting nanopillar structures over their membrane. This technique, with excellent performance despite the nonplanar surface of the wings, combines the top-down and bottom-up nanofabrication techniques. It transits micro-nanofabrication from cleanroom environment to bench. Two different materials - dicing tape with acrylic layer and UV optical adhesive - are used to make replications at the same time, thus achieving duplex imprint...
December 15, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29244625/the-role-of-oxytocin-and-vasopressin-in-attachment
#20
C Sue Carter
Selective relationships and attachments are central to human health and well-being, both in current societies and during the course of evolution. The presence or absence of social bonds has consequences across the lifespan. The neurobiology of attachment is grounded in neuroendocrine substrates that are shared with reproduction and survival. Experimental studies of species, such as sheep or prairie voles, capable of showing selective social behaviors toward offspring or partners, have provided empirical evidence for the role of oxytocin and vasopressin in the formation of selective attachments...
2017: Psychodynamic Psychiatry
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