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ucp2 Ca2+ ER

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https://www.readbyqxmd.com/read/24806964/ip3-mediated-stim1-oligomerization-requires-intact-mitochondrial-ca2-uptake
#1
Andras T Deak, Sandra Blass, Muhammad J Khan, Lukas N Groschner, Markus Waldeck-Weiermair, Seth Hallström, Wolfgang F Graier, Roland Malli
Mitochondria contribute to cell signaling by controlling store-operated Ca(2+) entry (SOCE). SOCE is activated by Ca(2+) release from the endoplasmic reticulum (ER), whereupon stromal interacting molecule 1 (STIM1) forms oligomers, redistributes to ER-plasma-membrane junctions and opens plasma membrane Ca(2+) channels. The mechanisms by which mitochondria interfere with the complex process of SOCE are insufficiently clarified. In this study, we used an shRNA approach to investigate the direct involvement of mitochondrial Ca(2+) buffering in SOCE...
July 1, 2014: Journal of Cell Science
https://www.readbyqxmd.com/read/21775425/uncoupling-protein-3-ucp3-modulates-the-activity-of-sarco-endoplasmic-reticulum-ca2-atpase-serca-by-decreasing-mitochondrial-atp-production
#2
Umberto De Marchi, Cyril Castelbou, Nicolas Demaurex
The uncoupling proteins UCP2 and UCP3 have been postulated to catalyze Ca(2+) entry across the inner membrane of mitochondria, but this proposal is disputed, and other, unrelated proteins have since been identified as the mitochondrial Ca(2+) uniporter. To clarify the role of UCPs in mitochondrial Ca(2+) handling, we down-regulated the expression of the only uncoupling protein of HeLa cells, UCP3, and measured Ca(2+) and ATP levels in the cytosol and in organelles with genetically encoded probes. UCP3 silencing did not alter mitochondrial Ca(2+) uptake in permeabilized cells...
September 16, 2011: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/21613221/leucine-zipper-ef-hand-containing-transmembrane-protein-1-letm1-and-uncoupling-proteins-2-and-3-ucp2-3-contribute-to-two-distinct-mitochondrial-ca2-uptake-pathways
#3
Markus Waldeck-Weiermair, Claire Jean-Quartier, Rene Rost, Muhammad Jadoon Khan, Neelanjan Vishnu, Alexander I Bondarenko, Hiromi Imamura, Roland Malli, Wolfgang F Graier
Cytosolic Ca(2+) signals are transferred into mitochondria over a huge concentration range. In our recent work we described uncoupling proteins 2 and 3 (UCP2/3) to be fundamental for mitochondrial uptake of high Ca(2+) domains in mitochondria-ER junctions. On the other hand, the leucine zipper EF hand-containing transmembrane protein 1 (Letm1) was identified as a mitochondrial Ca(2+)/H(+) antiporter that achieved mitochondrial Ca(2+) sequestration at small Ca(2+) increases. Thus, the contributions of Letm1 and UCP2/3 to mitochondrial Ca(2+) uptake were compared in endothelial cells...
August 12, 2011: Journal of Biological Chemistry
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