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https://www.readbyqxmd.com/read/28528299/selective-targeting-and-therapy-of-metastatic-and-multidrug-resistant-tumors-using-a-long-circulating-podophyllotoxin-nanoparticle
#1
Aniruddha Roy, Yucheng Zhao, Yang Yang, Andras Szeitz, Tara Klassen, Shyh-Dar Li
Treatment options for metastatic and multidrug resistant (MDR) tumors are limited, and most of the chemotherapeutic drugs exhibit low efficacy against MDR cancers. An anti-tubulin agent podophyllotoxin (PPT) displays high potency against MDR tumor cells. However, due to its poor solubility and non-specificity, PPT cannot be used systemically. We have developed a self-assembling nanoparticle dosage form for PPT (named Celludo) by covalently conjugating PPT and polyethylene glycol (PEG) to acetylated carboxymethyl cellulose (CMC-Ac) via ester linkages...
May 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28527822/synthesis-and-biological-evaluation-of-new-c-12-%C3%AE-%C3%AE-n-sulfamoyl-phenylamino-14-deoxy-andrographolide-derivatives-as-potent-anti-cancer-agents
#2
Sai Giridhar Sarma Kandanur, Srinivas Nanduri, Nageswara Rao Golakoti
Andrographolide, the major diterpenoidal constituent of Andrographis paniculata (Acanthaceae) and its derivatives have been reported to possess plethora of biological properties including potent anti-cancer activity. In this work, synthesis and in-vitro anti-cancer evaluation of new C-12-substituted aryl amino 14-deoxy-andrographolide derivatives (III a-f) are reported. The substitutions include various sulfonamide moieties -SO2-NH-R(1). The new derivatives (III a-e) exhibited improved cytotoxicity (GI50, TGI and LC50) compared to andrographolide (I) and the corresponding 3,14,19-O-triacetyl andrographolide (II) when evaluated against 60 NCI cell line panel...
April 13, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28525840/indole-carboxylic-acid-esters-of-melampomagnolide-b-are-potent-anticancer-agents-against-both-hematological-and-solid-tumor-cells
#3
Shobanbabu Bommagani, Jessica Ponder, Narsimha R Penthala, Venumadhav Janganati, Craig T Jordan, Michael J Borrelli, Peter A Crooks
A series of novel, heteroaryl carboxylic acid conjugates of the sesquiterpene melampomagnolide-B (MMB, 3) has been evaluated as antitumor agents against an NCI panel of 64 human hematopoetic and solid tumor cell lines. The indole-3-acrylic acid conjugate 7j and the indole-3-carboxylic acid conjugate 7k were found to be the most potent analogs in the series. Compounds 7j and 7k exhibited remarkable growth inhibition, with GI50 values in the range 0.03-0.30 μM and 0.04-0.28 μM, respectively, against the cell lines in the leukemia sub-panel, and GI50 values of 0...
May 11, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28525661/comparison-between-mononucleotide-and-dinucleotide-marker-panels-in-gastric-cancer-with-loss-of-hmlh1-or-hmsh2-expression
#4
Jeong Goo Kim, Soyoung Shin, Joonhong Park
BACKGROUND: DNA mismatch repair deficiency is an important molecular mechanism of genetic instability in gastric cancer, and a high instability at microsatellites is associated with favorable prognosis. We compared mononucleotide and dinucleotide microsatellite instability (MSI) marker panels in 56 paired gastric tumor and normal samples. METHODS: The mononucleotide marker panel (mono panel) consisted of 8 markers: BAT25, BAT26, BAT40, BAT-RII, NR21, NR22, NR24 and NR27...
May 16, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28523111/discovery-of-orally-efficacious-tetrahydrobenzimidazoles-as-tgr5-agonists-for-type-2-diabetes
#5
Xuqing Zhang, Mark Wall, Zhihua Sui, Jack Kauffman, Cuifen Hou, Cailin Chen, Fuyong Du, Thomas Kirchner, Yin Liang, Dana L Johnson, William V Murray, Keith Demarest
We have discovered a novel series of tetrahydrobenzimidazoles 3 as TGR5 agonists. Initial structure-activity relationship studies with an assay that measured cAMP levels in murine enteroendocrine cells (STC-1 cells) led to the discovery of potent agonists with submicromolar EC50 values for mTGR5. Subsequent optimization through methylation of the 7-position of the core tetrahydrobenzimidazole ring resulted in the identification of potent agonists for both mTGR5 and hTGR5 (human enteroendocrine NCI-H716 cells)...
May 11, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28522279/-stereotactic-lung-radiotherapy-technical-setting-up-on-novalis-tx-%C3%A2-and-single-centre-prospective-study-of-the-100-first-malignant-pulmonary-nodules-treated-at-centre-jean-perrin
#6
A Bellière-Calandry, G Dupic, F Magnier, V Chassin, V Dedieu, M Lapeyre
PURPOSE: Description of the treatment technique of stereotactic lung radiotherapy on Novalis Tx(®) and prospective study of the first 100 pulmonary nodules treated at centre Jean-Perrin (France). MATERIAL AND METHODS: From October 2012 to December 2015, 100 inoperable pulmonary nodules (62 stage I non-small-cell lung cancer and 38 metastases) of 90 patients with a mean age of 68.2 years (range: 46-89 years) were prospectively treated with dynamic arctherapy on Novalis Tx(®)...
May 15, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28521628/cd36-positive-b-lymphoblasts-predict-poor-outcome-in-children-with-b-lymphoblastic-leukemia
#7
Joanna G Newton, John T Horan, Scott Newman, Michael R Rossi, Rhett P Ketterling, Sunita I Park
Objective We observed that pediatric patients with B lymphoblastic leukemia which expressed CD36 at diagnosis seemed to have worse outcome than patients whose blasts did not. Here, we describe the patient, disease characteristics, pathological, molecular, and genetic features and outcomes of patients with CD36+ B-LL compared to patients with CD36- B-LL. Methods We retrospectively reviewed all flow cytometry reports from September 2008 to December 2015 to identify patients diagnosed at our institution with CD36 expression on B lymphoblasts...
June 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28521488/mir-137-inhibits-the-proliferation-of-human-non-small-cell-lung-cancer-cells-by-targeting-src3
#8
Ruilin Chen, Yongqing Zhang, Chengcheng Zhang, Hua Wu, Shumei Yang
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The results of the present study demonstrate that high expression of microRNA (miR)-137 and low expression of steroid receptor coactivator-3 (SRC3) had a significant negative correlation in 40 NSCLC tissue samples. In addition, cell colony formation and proliferation was significantly reduced in miR-137-transfected A549 and NCI-H838 cells compared with scramble-transfected NSCLC cell lines. miR-137 was identified to induce G1/S cell cycle arrest and dysregulate the mRNA expression of cell cycle-associated proteins (proliferating cell nuclear antigen, cyclin E, cyclin A1, cyclin A2 and p21) in NSCLC cells...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28515157/carboxyamidotriazole-synergizes-with-sorafenib-to-combat-non-small-cell-lung-cancer-through-inhibition-of-nanog-and-aggravation-of-apoptosis
#9
Chen Chen, Rui Ju, Jing Shi, Wei Chen, Fangrui Sun, Lei Zhu, Juan Li, Dechang Zhang, Caiying Ye, Lei Guo
Lung cancer is the leading cause of cancer-related deaths in the world. In this study, we investigated the combination of carboxyamidotriazole (CAI) and sorafenib in NSCLC in vitro and in vivo, to test whether CAI enhances the antitumor effects of sorafenib and reduces its side effects. The combination index (CI) showed that co-administration of CAI and sorafenib synergistically inhibited the proliferation of NSCLC cells (Lewis lung carcinoma, A549, NCI-H1975). The cell death led by the treatment of combination drugs was attributed to apoptosis which was accompanied with activation of caspase 3 and poly ADP-ribose polymerase...
May 17, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28514745/combating-acquired-resistance-to-trastuzumab-by-an-anti-erbb2-fully-human-antibody
#10
Chao Wang, Lingfei Wang, Xiaojie Yu, Yajun Zhang, Yanchun Meng, Huajing Wang, Yang Yang, Jie Gao, Huafeng Wei, Jian Zhao, Cuihua Lu, Han Chen, Yanping Sun, Bohua Li
Trastuzumab resistance is a common problem that impedes the effectiveness of trastuzumab in ErbB2-amplified cancers. About 70% of ErbB2-amplified breast cancers do not respond to trastuzumab (de novo resistance), and the majority of the trastuzumab-responsive cancers progress within 1 year (acquired resistance). Different mechanisms exist between de novo and acquired resistance. Innate resistance mechanisms are mainly independent of ErbB2 receptor activity, and acquired resistance involves with alterations depending on ErbB2 activity...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28514062/locoregional-therapy-with-%C3%AE-emitting-trastuzumab-against-peritoneal-metastasis-of-her2-positive-gastric-cancer-in-mice
#11
Huizi Keiko Li, Yukie Morokoshi, Kotaro Nagatsu, Tadashi Kamada, Sumitaka Hasegawa
Peritoneal metastasis of gastric cancer (PMGC) is incurable and thus has an extremely poor prognosis. We have found however that locoregionally administered trastuzumab armed with a radionuclide astatine-211 ((211) At)-emitting α-particle ((211) At-trastuzumab) is effective against HER2-positive PMGC in a xenograft mouse model. We first observed that (211) At-trastuzumab can specifically bind and effectively kill NCI-N87 (N87) cells, which are HER2-positive human metastatic GC cells, both in vitro and in subcutaneous tumors...
May 17, 2017: Cancer Science
https://www.readbyqxmd.com/read/28509438/deguelin-inhibits-epithelial-to-mesenchymal-transition-and-metastasis-of-human-non-small-cell-lung-cancer-cells-by-regulating-nima-related-kinase-2
#12
Dejian Zhao, Wenzheng Han, Xia Liu, Dawei Cui, Yu Chen
BACKGROUND: Non-small cell lung cancer is a lethal malignancy with a high mortality rate. Deguelin displays an anti-tumor effect and inhibits metastasis in various cancers. The aberrant expression of NIMA-related kinase 2 (NEK2) indicates poor prognosis and induces epithelial-to-mesenchymal transition (EMT) and metastasis processes. However, the underlying mechanism between deguelin and NEK2 has remained elusive. METHODS: NSCLC cell lines were treated with deguelin...
May 16, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28508839/application-of-national-cancer-institute-recommended-terminology-in-breast-cytology
#13
P Arul, Suresh Masilamani
BACKGROUND: There is a lack of uniformity with regard to the reporting terminology used in breast cytology by pathologists worldwide, resulting in miscommunication of results among health-care providers. AIM: The present study was aimed to assess the accuracy of fine-needle aspiration cytology (FNAC) in the evaluation of breast lesions using the National Cancer Institute (NCI) recommended terminology. MATERIALS AND METHODS: In this prospective study, a total number of 523 breast FNACs were categorized according to the NCI guidelines...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28508744/overexpression-of-human-papillomavirus-type-16-oncoproteins-enhances-epithelial-mesenchymal-transition-via-stat3-signaling-pathway-in-non-small-cell-lung-cancer-cells
#14
Wenzhang Zhang, Xin Wu, Liang Hu, Yuefan Ma, Zihan Xiu, Bingyu Huang, Yun Feng, Xudong Tang
Human papillomavirus (HPV) infection may be associated with the development and progression of non-small cell lung cancer (NSCLC). However, the role of HPV-16 oncoproteins in the development and progression of NSCLC is not completely clear. Epithelial-mesenchymal transition (EMT), a crucial step for invasion and metastasis, plays a key role in the development and progression of NSCLC. Here, we explored the effect of HPV-16 oncoproteins on EMT and the underlying mechanisms. NSCLC cell lines, A549 and NCI-H460, were transiently transfected with EGFP-N1-HPV-16 E6 or E7 plasmid...
December 15, 2016: Oncology Research
https://www.readbyqxmd.com/read/28507275/quantitative-proteomics-profiling-reveals-activation-of-mtor-pathway-in-trastuzumab-resistance
#15
Wenhu Liu, Jinxia Chang, Mingwei Liu, Jiangbei Yuan, Jinqiang Zhang, Jun Qin, Xuefeng Xia, Yi Wang
Trastuzumab is an antibody-based therapy drug targeting HER2-overexpressing tumors. While it has been proven to be very successful initially, most patients eventually develop resistance to trastuzumab. The mechanism of drug resistance is not well understood. Identifying pathways that mediate trastuzumab resistance will improve our understanding of the underlying mechanism and is crucial for the development of therapeutic strategies to overcome resistance.Here we report a quantitative proteomics profiling of a trastuzumab-sensitive (T-S) gastric cancer cell line NCI N87 and a trastuzumab-resistant NCI N87 (T-R) subline generated by low-dose, continuous trastuzumab treatment...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28506975/national-survey-of-comprehensive-pharmacy-services-provided-in-cancer-clinical-trials
#16
Anand Khandoobhai, Ming Poi, Katherine Kelley, Jay Mirtallo, Ben Lopez, Niesha Griffith
PURPOSE: Pharmacy services provided in clinical trials at National Cancer Institute (NCI)-designated centers were assessed. METHODS: This was a cross-sectional survey of 61 NCI-designated cancer centers. Directors of pharmacy were contacted and data were collected electronically via Qualtrics over 2 months. Trial participants were asked to estimate the frequency that their sites performed 26 services and the perceived importance of these services. Services were examined with respect to the difference between their reported performance and their reported importance...
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28506750/cytotoxic-and-apoptosis-inducing-activities-against-human-lung-cancer-cell-lines-of-cassaine-diterpenoids-from-the-bark-of-erythrophleum-fordii
#17
Manh Tuan Ha, Manh Hung Tran, Thien Thuong Phuong, Jeong Ah Kim, Mi Hee Woo, Jae Sue Choi, Suhyun Lee, Jeong Hyung Lee, Hyeong Kyu Lee, Byung Sun Min
A phytochemical investigation into the bark of Erythrophleum fordii yielded four new compounds, two new cassaine diterpenoids (erythrofordin T and U, 1 and 2) and two new cassaine diterpenoid amines (erythroformine A and B, 6 and 7), as well as nine known compounds. We report for the first time the isolation of erythrofordin V (3) from a natural source and that of the remaining eight known diterpenoids (4-5, 8-13) from E. fordii. All structures were elucidated using spectroscopic analysis. Cytotoxic activity of the isolated compounds (1-13) was examined in vitro against three non-small cell lung cancer cell lines (A549, NCI-H1975, and NCI-H1229) using the MTT assay...
May 4, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28506242/an-imprinted-non-coding-genomic-cluster-at-14q32-defines-clinically-relevant-molecular-subtypes-in-osteosarcoma-across-multiple-independent-datasets
#18
Katherine E Hill, Andrew D Kelly, Marieke L Kuijjer, William Barry, Ahmed Rattani, Cassandra C Garbutt, Haydn Kissick, Katherine Janeway, Antonio Perez-Atayde, Jeffrey Goldsmith, Mark C Gebhardt, Mohamed S Arredouani, Greg Cote, Francis Hornicek, Edwin Choy, Zhenfeng Duan, John Quackenbush, Benjamin Haibe-Kains, Dimitrios Spentzos
BACKGROUND: A microRNA (miRNA) collection on the imprinted 14q32 MEG3 region has been associated with outcome in osteosarcoma. We assessed the clinical utility of this miRNA set and their association with methylation status. METHODS: We integrated coding and non-coding RNA data from three independent annotated clinical osteosarcoma cohorts (n = 65, n = 27, and n = 25) and miRNA and methylation data from one in vitro (19 cell lines) and one clinical (NCI Therapeutically Applicable Research to Generate Effective Treatments (TARGET) osteosarcoma dataset, n = 80) dataset...
May 15, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28499366/the-role-of-brca1-iris-in-the-development-and-progression-of-triple-negative-breast-cancers-in-egypt-possible-link-to-disease-early-lesion
#19
Danielle Bogan, Lucio Meile, Ahmed El Bastawisy, Hend F Yousef, Abdel-Rahman N Zekri, Abeer A Bahnassy, Wael M ElShamy
BACKGROUND: Breast cancer is the most globally diagnosed female cancer, with the triple negative breast cancer (TNBC) being the most aggressive subtype of the disease. In this study we aimed at comparing the effect of BRCA1-IRIS overexpression on the clinico-pathological characteristics in breast cancer patients with TNBC or non-TNBC in the largest comprehensive cancer center in Egypt. METHODS: To reach this goal, we conducted an observational study at the National Cancer Institute (NCI), Cairo University (Cairo, Egypt)...
May 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28498474/effect-of-mir-1244-on-cisplatin-treated-non-small-cell-lung-cancer-via-mef2d-expression
#20
Guang-Jian Li, Guang-Qiang Zhao, Jia-Peng Yang, Yong-Chun Zhou, Kai-Yun Yang, Yu-Jie Lei, Yun-Chao Huang
The aim of this study was to investigate the function of miR-1244 in cisplatin-treated non-small cell lung cancer (NSCLC). The results of quantitative PCR analysis revealed that the expression levels of miR-1244 in cisplatin‑treated A549 and NCI-H522 human lung cancer cell lines were lower than those in untreated A549 and NCI-H522 cells. Similarly, the expression level of miR-1244 in NSCLC tissue samples from cisplatin-treated patients was also lower than that in non-cisplatin-treated NSCLC patients. Notably, the overall survival times of cisplatin-treated NSCLC patients with high miR-1244 expression were superior to those patients with low miR-1244 expression...
May 4, 2017: Oncology Reports
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