Victor Baeza, Manuel Cifuentes, Fernando Martínez, Eder Ramírez, Francisco Nualart, Luciano Ferrada, María José Oviedo, Isabelle De Lima, Ninoschka Troncoso, Natalia Saldivia, Katterine Salazar
Ependymal cells have multiple apical cilia that line the ventricular surfaces and the central canal of spinal cord. In cancer, the loss of ependymal cell polarity promotes the formation of different types of tumors, such as supratentorial anaplastic ependymomas, which are highly aggressive in children. IIIG9 (PPP1R32) is a protein restricted to adult ependymal cells located in cilia and in the apical cytoplasm and has unknown function. In this work, we studied the expression and localization of IIIG9 in the adherens junctions (cadherin/β-catenin-positive junctions) of adult brain ependymal cells using confocal and transmission electron microscopy...
September 17, 2021: Scientific Reports