Victor Hugo Bustos, Yashoda Krishna Sunkari, Anjana Sinha, Maria Pulina, Ashley Bispo, Maya Hopkins, Alison Lam, Sydney F Kriegsman, Emily Mui, Emily Chang, Ana Jedlicki, Hannah Rosenthal, Marc Flajolet, Subhash C Sinha
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by the accumulation of β-amyloid (Aβ), C99, and Tau in vulnerable areas of the brain. Despite extensive research, current strategies to lower Aβ levels have shown limited efficacy in slowing the cognitive decline associated with AD. Recent findings suggest that C99 may also play a crucial role in the pathogenesis of AD. Our laboratory has discovered that CK1γ2 phosphorylates Presenilin 1 at the γ-secretase complex, leading to decreased C99 and Aβ levels...
December 11, 2023: ACS Chemical Biology