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cry it out

Qing Zhou, Guanghui Li, Yuanjian Zhang, Min Zhu, Yakun Wan, Yanfei Shen
Cry1C is one of the emerging toxin proteins produced by the Bacillus thuringiensis in the genetically modified crops for pest control in agriculture; thus, it is vital to measure the Cry1C level in crops for the healthy and environmental concerns. Current detections of Cry1C mainly rely on instrumental analysis such as high-performance liquid chromatography, which are time-consuming and are generally cost-prohibitive. Herein, a simple nanobodies (Nbs)-based electrochemical immunosensor has been first proposed for highly selective and sensitive detection of Cry1C...
October 4, 2016: Analytical Chemistry
Ian St James-Roberts, Marion Roberts, Kimberly Hovish, Charlie Owen
: Aim To provide descriptive figures for infant distress and associated parenting at night in normal London home environments during the first three months of age. BACKGROUND: Most western infants develop long night-time sleep periods by four months of age. However, 30% of infants in many countries sleep for short periods and cry out on waking in the night: the most common type of infant sleep behaviour problem. Preventive interventions may help families and improve services...
November 2016: Primary Health Care Research & Development
Alain Lesage
This essay comprises 2 parts. It aims to recognize the public service of psychiatrists of the Département de psychiatrie de l'Université de Montréal who served at the provincial level of the Ministry of Health and Social Services for deinstitutionalisation of policies and organisation of services, at the service of people with severe mental disorders. First with Dr. Camille Laurin post-face of the 1962 book Les fous crient au secours! (Mentally ill patients cry for help); then the insight on the latest phase of differentiated specialised clinics by Dr...
2015: Santé Mentale Au Québec
Davi F Farias, Ad A C M Peijnenburg, Maria F Grossi-de-Sá, Ana F U Carvalho
Insecticidal Cry proteins from Bacillus thuringiensis (Bt) have been exploited in the development of genetically modified (GM) crops for pest control. However, several pests are still difficult to control such as the coleopteran boll weevil Anthonomus grandis. By applying in vitro molecular evolution to the cry8Ka1 gene sequence, variants were generated with improved activity against A. grandis. Among them, Cry8Ka5 mutant protein showed coleoptericidal activity 3-fold higher (LC50 2.83 μg/mL) than that of the original protein (Cry8Ka1)...
2015: Bioengineered
M Akhtaruzzaman, M A Hossain, M R Karim, R H Khan, M S Islam, F Ahamed, N Khan, S U Ahammed, S K Dhar, A A Mahmud, A K Khan, S Nahar
This descriptive cross sectional study was conducted in Pediatric Out Patient Department (OPD) of Mymensingh Medical College Hospital (MMCH) from November 2013 to April 2014 to assess the knowledge and practices of the mothers about breastfeeding. Four hundred mothers having children 6 months to 2 years of age attended at OPD of MMCH for any cause were included in the study by systematic random sampling. A structured, pre-tested, interview schedule was used to collect data from mothers. All mothers were continuing to breastfeed their children...
July 2015: Mymensingh Medical Journal: MMJ
Ran D Goldman
QUESTION: I have children in my clinic who experience seizurelike episodes in which they cry and hold their breath to the point of cyanosis and loss of consciousness. Their examination or investigation findings are normal and referral to a pediatric specialist results in no further investigation. Are breath-holding spells common, and what type of investigation is needed? ANSWER: A breath-holding spell is a benign paroxysmal nonepileptic disorder occurring in healthy children 6 to 48 months of age...
February 2015: Canadian Family Physician Médecin de Famille Canadien
Jin Young Kim, Pieter Bas Kwak, Michael Gebert, Hao A Duong, Charles J Weitz
In mammals, circadian rhythms are generated at least in part by a cell-autonomous transcriptional feedback loop in which the three PERIOD (PER) and two CRYPTOCHROME (CRY) proteins inhibit the activity of the dimeric transcription factor CLOCK-BMAL1, thereby repressing their own expression. Upon nuclear entry, the PER and CRY proteins form a large protein complex (PER complex) that carries out circadian negative feedback by means of at least two basic functions: (1) it brings together multiple effector proteins that repress transcription and (2) it delivers these repressive effectors directly to CLOCK-BMAL1 bound to E-box sequences of circadian target genes...
2015: Methods in Enzymology
Nai-Wan Hsiao, Tien-Sheng Tseng, Yu-Ching Lee, Wang-Chuan Chen, Hui-Hsiung Lin, Yun-Ru Chen, Yeng-Tseng Wang, Hung-Ju Hsu, Keng-Chang Tsai
Tyrosinase, which is the crucial copper-containing enzyme involved in melanin synthesis, is strongly associated with hyperpigmentation disorders, cancer, and neurodegenerative disease; thus, it has attracted considerable interest in the fields of medicine and cosmetics. The known tyrosinase inhibitors show numerous adverse side effects, and there is a lack of safety regulations governing their use. As a result, there is a need to develop novel inhibitors with no toxicity and long-term stability. In this study, we use molecular docking and pharmacophore modeling to construct a reasonable and reliable pharmacophore model, called Hypo 1, that could be used for identifying potent natural products with crucial complementary functional groups for mushroom tyrosinase inhibition...
November 24, 2014: Journal of Chemical Information and Modeling
Carl Friedrich Classen
Whenever a child suffers, what does she or he cry Mother! What does that mean Palliative care is not a type of medicine based on objective evidence or statistics. The only relevant standard is the very individual quality of life. Nobody knows better what this actually means but the patient himself. Thus, if the mother's presence has the biggest impact on a child's wellbeing or comfort, she herself is the most valuable treatment modality. In nearly every publication dealing with pediatric palliative care, it is stated that palliative care does not only imply care for the sick child but also for the parents and the whole family...
October 8, 2012: World Journal of Clinical Pediatrics
Hafsa Raheel
OBJECTIVES: Secondary school girls, ages 15 - 19 yrs were surveyed to find out the coping strategies they used when stressed. Adolescents, who are affected with stress and depression early in life, suffer from depression throughout their lives especially if they are utilizing improper ways to cope with it. METHODS: A cross sectional school based survey among 1028 adolescent girls was conducted among the secondary schools in Riyadh city,Kingdom of Saudi Arabia. RESULTS: About 25% stated that they cry, 19% listen to music, 15% start eating a lot, 12% sit alone/isolate themselves, 11% pray/read the Quran, 10% get into a verbal argument or a fight...
September 2014: Pakistan Journal of Medical Sciences Quarterly
P M Hunn
Alhough leprosy is a very ancient disease, it is only within the last few decades that it has come into the orbit of the physiotherapist. Yet today, the place of physiotherapy in the treatment of leprosy is being increasingly recognised. The cry, as in most fields, is that there are not enough physiotherapists to meet the need, and so there are thousands, perhaps more accurately, millions, of leprosy patients who are condemned to a life marred by crippling deformity, which could have been prevented if only … there had been a physiotherapist available to teach others the techniques of re-education, and if only … there was a physiotherapist available to do some research into more effective methods of treating the early signs of nerve damage and muscle weakness...
September 1972: Australian Journal of Physiotherapy
Ewa Ziemann, Robert A Olek, Tomasz Grzywacz, Jan J Kaczor, Jędrzej Antosiewicz, Wojciech Skrobot, Sylwester Kujach, Radosław Laskowski
Inflammation may accompany obesity and a variety of diseases, or result from excessive exercise. The aim of this study was to investigate the anti-inflammatory effect of whole-body cryostimulation on the inflammatory response induced by eccentric exercise under laboratory conditions. The study also sought to establish if cold treatment changes the lipid profile and modifies energy expenditure in young people. Eighteen healthy and physically active, college-aged men volunteered to participate in the experiment...
March 1, 2014: European Cytokine Network
Hugara Siddalingappa, Nrayana Murthy M R, Praveen Kulkarni, Ashok N C
BACKGROUND: With decreasing Infant Mortality Rate, Perinatal Mortality is gaining importance as it takes into consideration most of the factors influencing child birth and its survival, mortality during this period is a better indicator of quality of Maternal and Child Health services. OBJECTIVES: To estimate the Prevalence of perinatal mortality and its associated risk factors. METHODOLOGY: Cross sectional community based study was carried out in rural field practice area catering 26,700 population...
December 2013: Journal of Clinical and Diagnostic Research: JCDR
Sung Kook Chun, Jaebong Jang, Sooyoung Chung, Hwayoung Yun, Nam-Jung Kim, Jong-Wha Jung, Gi Hoon Son, Young-Ger Suh, Kyungjin Kim
Circadian rhythms, biological oscillations with a period of about 24 h, are maintained by a genetically determined innate time-keeping system called the molecular circadian clockwork. Despite the physiological and clinical importance of the circadian clock, the development of small molecule modulators that directly target the core clock machinery has only been recently initiated. In the present study, we aimed to identify novel small molecule modulators influencing the molecular feedback loop of the circadian clock by applying our two-step cell-based screening strategy based on E-box-mediated transcriptional activity to test more than 1000 drug-like compounds...
March 21, 2014: ACS Chemical Biology
Alexandra Voorthuis, Dorothée Out, Rixt van der Veen, Ritu Bhandari, Marinus H van IJzendoorn, Marian J Bakermans-Kranenburg
Children vary hugely in how demanding of their caregivers they are. This creates differences in demands on parents during observation, making the comparison of sensitivity between parents difficult. It would therefore be of interest to create standard situations in which all caregivers are faced with the same level of demand. This study developed an ecologically valid but standardized setting using an infant simulator with interactive features, the Leiden Infant Simulator Sensitivity Assessment (LISSA). The infant simulator resembles a real infant in appearance and it produces crying sounds that are life-like...
2013: Attachment & Human Development
Sunil Mhaske, Sandeep Mhaske, S Badrinarayan, Rohan Zade, Ujjwala Shirsath
Infantile colic in exclusively breastfed infant is very common. The mother in this situation gets panickyand under stress. This is very common emergency in paediatric hospital. Infantile colic is characterised by paroxysms of uncontrollable crying in an otherwise healthy and well fed infants younger than three months of age, more specifically infantile colic is defined as cry exceeding 180 minutes per 24 hours on 3 days in the week in first 3 months of life. The incidence of infantile colic is 5 to 19% in different studies...
May 2012: Journal of the Indian Medical Association
Sunit C Singhi, Ravi Shah, Arun Bansal, M Jayashree
Vomiting is a protective reflex that results in forceful ejection of stomach contents up to and out of the mouth. It is a common complaint and may be the presenting symptom of several life-threatening conditions. It can be caused by a variety of organic and nonorganic disorders; gastrointestinal (GI) or outside of GI. Acute gastritis and gastroenteritis (AGE) are the leading cause of acute vomiting in children. Important life threatening causes in infancy include congenital intestinal obstruction, atresia, malrotation with volvulus, necrotizing enterocolitis, pyloric stenosis, intussusception, shaken baby syndrome, hydrocephalus, inborn errors of metabolism, congenital adrenal hypoplasia, obstructive uropathy, sepsis, meningitis and encephalitis, and severe gastroenteritis, and in older children appendicitis, intracranial mass lesion, diabetic ketoacidosis, Reye's syndrome, toxic ingestions, uremia, and meningitis...
April 2013: Indian Journal of Pediatrics
S N Singh, Roli Srivastava, Anita Singh, M Tahazzul, Mala Kumar, Chandra Kanta, S Chandra
OBJECTIVE: This study aimed to find out incidence, predictors, onset and severity of respiratory distress including meconium aspiration syndrome (MAS) among vigorous neonates born through meconium stained amniotic fluid (MSAF), which may or may not be evident at birth. METHODS: Two hundred ninety vigorous neonates were studied. Data were collected on perinatal risk factors, clinical course and development of respiratory distress. Predictors of respiratory distress were identified by logistic regression and a score based on adjusted OR was assigned for each...
July 2013: Indian Journal of Pediatrics
Manisha Sharma, Alankruta R Dave, V D Shukla
Tamaka Shvasa is a type of Shvasa Roga associated with difficulty in breathing as a result of which the patient prefers to sit in bed to get relief from his discomfort. Movement of air through Pranavaha Srotas is hampered in this disease resulting in the cry of organ heading toward complete failure for want of air. Tamaka Shvasa is well known for its episodic and chronic course which comes under the life-threatening disease. It is analogous to bronchial asthma due to similarity in symptoms, pathogenesis, onset, causes, and precipitating factors...
October 2011: Ayu
Paul E Hardin
A genetic screen for mutants that alter circadian rhythms in Drosophila identified the first clock gene-the period (per) gene. The per gene is a central player within a transcriptional feedback loop that represents the core mechanism for keeping circadian time in Drosophila and other animals. The per feedback loop, or core loop, is interlocked with the Clock (Clk) feedback loop, but whether the Clk feedback loop contributes to circadian timekeeping is not known. A series of distinct molecular events are thought to control transcriptional feedback in the core loop...
2011: Advances in Genetics
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