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IL-17 gene polymorphism

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https://www.readbyqxmd.com/read/27890033/il-8-il-17-gene-variations-and-the-susceptibility-to-severe-viral-bronchiolitis
#1
L A Pinto, L A DE Azeredo Leitão, M Mocellin, P Acosta, M T Caballero, R Libster, J E Vargas, F Polack, T Comaru, R T Stein, A P DE Souza
Clinical manifestations of acute bronchiolitis (AB) vary from minimal disease to severe respiratory failure. The response to respiratory viral infections is possibly influenced by genetic polymorphisms linked to the regulation of the inflammatory response. In the present study, we investigated whether interleukin-8 (IL-8) and interleukin-17 (IL-17) genetic variants are associated with the severity of AB. A group of Brazilian infants hospitalized with AB and a control group (infants with no or mild AB, without hospitalization) were genotyped for four IL-8/IL-17 variations...
November 28, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27876593/intact-interferon-%C3%AE-response-against-coxiella-burnetii-by-peripheral-blood-mononuclear-cells-in-chronic-q-fever
#2
Teske Schoffelen, Julien Textoris, Chantal P Bleeker-Rovers, Amira Ben Amara, Jos W M van der Meer, Mihai G Netea, Jean-Louis Mege, Marcel van Deuren, Esther van de Vosse
OBJECTIVES: Q fever is caused by Coxiella burnetii, an intracellular bacterium that infects phagocytes. The aim of the present study was to investigate whether the C. burnetii-induced IFN-γ response is defective in chronic Q fever patients. METHODS: IFN-γ was measured in supernatants of C. burnetii-stimulated peripheral blood mononuclear cells (PBMCs) of 17 chronic Q fever patients and 17 healthy individuals. To assess IFN-γ responses, expression profiles of IFN-γ-induced genes in C...
November 19, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27799970/polymorphism-of-il-28b-gene-rs12979860-in-hcv-genotype-1patients-treated-by-pegylated-interferon-and-ribavirin
#3
Fahimeh Safarnezhad Tameshkel, Mohammad Hadi Karbalaie Niya, Msuodreza Sohrabi, Mahshid Panahi, Farhad Zamani, Farid Imanzade, Nasser Rakhshani
BACKGROUND: Nowadays, the immune response to hepatitis C (HCV) treatment has become a crucial issue mostly due to the interleukin 28B (IL-28B) polymorphism effects in chronic HCV patients. The aim of this study was to detect the polymorphism of IL-28B gene (rs12979860) in HCV genotype 1 patients treated with pegylated Interferon and Ribavirin. METHODS: From the 2010 to 2012, a total of 115 peripheral blood mononuclear cells (PBMCs) of HCV patients who presented to Gastrointestinal & Liver Disease Research Center (GILDRC), Firoozgar Hospital, Tehran, Iran were enrolled in this retrospective cross sectional study...
2016: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/27785055/il-10-1082a-g-592c-a-and-819t-c-polymorphisms-in-association-with-lung-cancer-susceptibility-a-meta-analysis
#4
Liang Liu, Feng Zheng
Numerous studies have examined the association between interleukin-10 (IL-10 -1082A/G, -592C/A, and -819T/C) gene polymorphisms and risk of lung cancer, but these have revealed inconsistent results. The aim of this study was to clarify the relationship between these polymorphisms and the risk of lung cancer by performing a meta-analysis. The published literature concerning IL-10 polymorphisms and lung cancer risk were retrieved by systematically searching PubMed, Embase, Web of Science, China National Knowledge Infrastructure, WanFang, and Database of Chinese Scientific and Technical Periodicals (VIP) database...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27774581/a-preliminary-study-of-new-single-polymorphisms-in-th17-pathway-for-psoriasis-in-the-korean-population
#5
Soo Young Kim, Min Seok Hur, Byung Gon Choi, Min Jung Kim, Yang Won Lee, Yong Beom Choe, Kyu Joong Ahn
Psoriasis is a polygenic and multifactorial disease showing ethnic differences in terms of its severity and frequency. Therapies targeting interleukin 17A (IL-17A), interleukin 17 receptor (IL-17R), and Janus kinases (JAKs) are in clinical development for the treatment of psoriasis, and their success suggests the essential role of these molecules in psoriasis. To investigate the genetic susceptibility in T helper 17 (Th17) cell signal transduction pathways for promoting psoriasis, we performed candidate gene and linkage disequilibrium analysis...
October 24, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27722983/relationships-between-common-and-novel-interleukin-6-gene-polymorphisms-and-risk-of-cervical-cancer-a-case-control-study
#6
Sabrina Zidi, Mouna Stayoussef, Bano L Alsaleh, Ezzedine Gazouani, Amel Mezlini, Bashayer H Ebrahim, Besma Yacoubi-Loueslati, Wassim Y Almawi
We investigated the association between six common and novel interleukin-6 (IL-6) polymorphisms with the risk of cervical cancer (CC) among Tunisians. Study subjects comprised 112 CC cases and 164 control women. Genotyping of IL-6 rs2069845, rs2069840, rs1474348, rs1800795, rs1800797, rs2069827 variants was done by real-time PCR, with defined clusters. The allelic and genotypic distributions of the tested IL-6 SNPs were comparable between CC patients and control women. Stratification according to FIGO staging revealed that rs1800795 homozygous major allele genotype (P = 0...
October 8, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27706622/investigation-on-ercc5-genetic-polymorphisms-and-the-development-of-gastric-cancer-in-a-chinese-population
#7
L Q Yang, Y Zhang, H F Sun
Our study aimed to investigate the role of 2 ERCC5 promoter SNPs (rs2094258 and rs751402) in the development of gastric cancer in the Chinese population. The present hospital-based case-control study consisted of 155 patients with gastric cancer and 246 healthy controls recruited between March 2012 and December 2014. Genotyping for the rs2094258 and rs751402 polymorphic sites was carried out using polymerase chain reaction-restriction fragment length polymorphism. Statistical analyses were conducted using the SPASS version 16...
August 26, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27670766/il17ra-gene-variants-and-anti-tnf-response-among-psoriasis-patients
#8
A Batalla, E Coto, J Gómez, N Eirís, D González-Fernández, C Gómez-De Castro, E Daudén, M Llamas-Velasco, R Prieto-Perez, F Abad-Santos, G Carretero, F S García, Y B Godoy, L F Cardo, B Alonso, S Iglesias, P Coto-Segura
Polymorphisms at genes encoding proteins involved in the pathogenesis of psoriasis (Psor) or in the mechanism of action of biological drugs could influence the treatment response. Because the interleukin (IL)-17 family has a central role in the pathogenesis of Psor, we hypothesized that IL17RA variants could influence the response to anti-TNF drugs among Psor patients. To address this issue we performed a cross-sectional study of Psor patients who received the biological treatments for the first time, with a follow-up of at least 6 months...
September 27, 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/27651521/hla-g-and-cd8-regulatory-t-cells-in-the-inflammatory-environment-of-preeclampsia
#9
Priscila Vianna, Andressa Mondadori, Moises E Bauer, Dinara Dornfeld, Jose Artur Chies
During pregnancy the maternal immune system is tolerant to fetal antigens via the engagement of immune regulatory mechanisms. Failure in regulating the maternal immunity to fetal antigens may lead to preeclampsia (PE). We addressed the role of HLAG gene polymorphisms and protein expression as well as regulatory T cells and Th1/Th2/Th17 cytokines in healthy and pathological pregnancies. Blood samples from 26 pregnant women with PE, 25 non-PE and 7 strictly healthy pregnant women were assessed. PBMCs were phenotyped for early activation markers (CD25 and CD69), regulatory T cell markers (CD8+CD28- and CD4+CD25highFoxp3+), ILT-2 (HLA-G receptor) and HLA-G...
September 20, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27595159/polymorphisms-of-il-17-and-icam-1-and-their-expression-in-guillain-barr%C3%A3-syndrome
#10
N K Kharwar, K N Prasad, K Singh, V K Paliwal, D R Modi
PURPOSE: Guillain Barré syndrome (GBS) is an acute inflammatory, autoimmune disorder of peripheral nervous system (PNS). Interleukin-17 (IL-17) and intercellular adhesion molecule-1 (ICAM-1) polymorphisms with higher expression levels have already been studied in many inflammatory and autoimmune diseases. However, the possible role of IL-17 and ICAM-1 polymorphisms in GBS remains unknown. Therefore, the current study investigated IL-17 (His161Arg, Glu126Gly) and ICAM-1 (Gly241Arg) polymorphisms...
September 5, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27591988/il17a-and-il17f-gene-polymorphism-association-with-psoriasis-risk-and-response-to-treatment-in-a-polish-population
#11
Monika Białecka, Roksana Ostasz, Mateusz Kurzawski, Adam Klimowicz, Honorata Fabiańczyk, Piotr Bojko, Violetta Dziedziejko, Krzysztof Safranow, Anna Machoy-Mokrzyńska, Marek Droździk
BACKGROUND: Recent studies have revealed the pivotal role of Th17 cells and interleukin-17 (IL-17) in plaque psoriasis development and treatment outcome. The IL-17 family consists of 6 structurally related cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F), of which IL-17A and IL-17F mediate similar biological effects. OBJECTIVES: The aim of this study was to evaluate an association between the IL17A (-197G>A; rs2275913) and IL17F (rs763780: T>C; rs11465553: G>A; rs2397084: T>C) polymorphisms with psoriasis susceptibility as well as response to topical and combined topical with narrow-band ultraviolet B (NB-UVB) therapy in a Polish population...
September 3, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27493142/genetic-determinants-and-postorthodontic-external-apical-root-resorption-in-czech-children
#12
P Borilova Linhartova, P Cernochova, J Kastovsky, Z Vrankova, M Sirotkova, L Izakovicova Holla
OBJECTIVE: Genes, involved in the modulation of inflammatory response and bone remodeling, play a role in the development of postorthodontic external apical root resorption (EARR). The aim of our study was to analyze possible associations between seven single nucleotide polymorphisms (SNPs) in interleukin-17A (IL-17), osteopontin (SPP1), purinoreceptor P2X7 (P2RX7), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) genes and EARR in children after orthodontic treatment...
August 5, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27479084/an-asthma-associated-il4r-variant-exacerbates-airway-inflammation-by-promoting-conversion-of-regulatory-t-cells-to-th17-like-cells
#13
Amir Hossein Massoud, Louis-Marie Charbonnier, David Lopez, Matteo Pellegrini, Wanda Phipatanakul, Talal A Chatila
Mechanisms by which regulatory T (Treg) cells fail to control inflammation in asthma remain poorly understood. We show that a severe asthma-associated polymorphism in the gene encoding the interleukin (IL)-4 receptor alpha chain (Il4ra(R576)) promotes conversion of induced Treg (iTreg) cells toward a T helper 17 (TH17) cell fate. This skewing is mediated by the recruitment by IL-4Rα(R576) of the growth-factor-receptor-bound protein 2 (GRB2) adaptor protein, which drives IL-17 expression by activating a pathway that involves extracellular-signal-regulated kinase, IL-6 and the transcription factor STAT3...
September 2016: Nature Medicine
https://www.readbyqxmd.com/read/27464962/identification-of-susceptibility-snps-in-il10-and-il23r-il12rb2-for-beh%C3%A3-et-s-disease-in-han-chinese
#14
Hongsong Yu, Minming Zheng, Lijun Zhang, Hua Li, Yunyun Zhu, Ling Cheng, Lin Li, Bolin Deng, Aize Kijlstra, Peizeng Yang
BACKGROUND: Although previous genome-wide association studies in various cohorts have identified several susceptibility loci underlying Behçet's disease (BD), this has not yet led to a breakthrough in the management of BD. OBJECTIVE: This study aimed to further investigate the association of 26 candidate single nucleotide polymorphisms with previous genome-wide association studies-identified nearly positive P values (5.0 × 10(-8) < P < 1.0 × 10(-5)) in Chinese Han patients with BD...
June 21, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27456903/-a-study-of-the-effect-of-the-genes-of-inflammatory-proteins-on-basic-personality-dimensions
#15
V E Golimbet, M V Alfimova, G I Korovaitseva, T V Lezheiko, N V Kondrat'ev, E V Krikova, M V Gabaeva, S V Kasparov, N Yu Kolesina
AIM: The present research examines the association between two basic dimensions of personality and genes of inflammatory cytokines and mediators reported to be elevated in schizophrenia and affective disorders. Genes of interleukin-1B (IL-1B), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP) and alpha 1-antitrypsin (A1AT) were studied. MATERIAL AND METHODS: A total of 639 healthy subjects, aged from 17 to 69 years, participated in the study...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27438086/a-natural-variant-of-the-t-cell-receptor-signaling-molecule-vav1-reduces-both-effector-t-cell-functions-and-susceptibility-to-neuroinflammation
#16
Sahar Kassem, Guillaume Gaud, Isabelle Bernard, Mehdi Benamar, Anne S Dejean, Roland Liblau, Gilbert J Fournié, Céline Colacios, Bernard Malissen, Abdelhadi Saoudi
The guanine nucleotide exchange factor Vav1 is essential for transducing T cell antigen receptor signals and therefore plays an important role in T cell development and activation. Our previous genetic studies identified a locus on rat chromosome 9 that controls the susceptibility to neuroinflammation and contains a non-synonymous polymorphism in the major candidate gene Vav1. To formally demonstrate the causal implication of this polymorphism, we generated a knock-in mouse bearing this polymorphism (Vav1R63W)...
July 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27399111/common-variants-in-il-17a-il-17ra-axis-contribute-to-predisposition-to-and-progression-of-congestive-heart-failure
#17
Chaugai Sandip, Lun Tan, Jin Huang, Qing Li, Li Ni, Katherine Cianflone, Dao Wen Wang
Heart failure is characterized by immune activation leading to production and release of proinflammatory cytokines. Interleukin 17A (IL-17A) is a proinflammatory cytokine and multiple lines of evidence from animal and human studies suggest crucial roles of IL-17A in heart failure. Therefore, we investigated whether common polymorphisms of genes IL17A and IL17RA (coding interleukin 17 receptor A) contribute to genetic predisposition to heart failure and adverse clinical outcomes associated with it.A total of 1713 adult patients with congestive heart failure and 1713 age- and sex-matched controls were genotyped for promoter single nucleotide polymorphisms (SNPs), rs2275913 and rs8193037 in IL17A and rs4819554 in IL17RA, to assess the relationship between individual SNPs and the risk of congestive heart failure...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27399105/impact-of-demographic-genetic-and-bioimpedance-factors-on-gestational-weight-gain-and-birth-weight-in-a-romanian-population-a-cross-sectional-study-in-mothers-and-their-newborns-the-monebo-study-strobe-compliant-article
#18
Claudiu Mărginean, Cristina Oana Mărginean, Claudia Bănescu, Lorena Meliţ, Florin Tripon, Mihaela Iancu
The present study had 2 objectives, first, to investigate possible relationships between increased gestational weight gain and demographic, clinical, paraclinical, genetic, and bioimpedance (BIA) characteristics of Romanian mothers, and second, to identify the influence of predictors (maternal and newborns characteristics) on our outcome birth weight (BW).We performed a cross-sectional study on 309 mothers and 309 newborns from Romania, divided into 2 groups: Group I-141 mothers with high gestational weight gain (GWG) and Group II-168 mothers with normal GWG, that is, control group...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27348238/association-between-gene-polymorphisms-on-chromosome-1-and-susceptibility-to-pre-eclampsia-an-updated-meta-analysis
#19
Guixin Zhang, Jinheng Zhao, Jianping Yi, Yuanyuan Luan, Qian Wang
BACKGROUND This meta-analysis enabled us to obtain a precise estimation of the association between gene polymorphisms on chromosome 1 (MTHFR, AGT, F5, IL-10, LEPR) and the susceptibility to pre-eclampsia (PE) in order to reach a uniform conclusion. MATERIAL AND METHODS Web of Science, PubMed, EMBASE, Cochran Library (CENTRAL), and Chinese databases (Chinese National Knowledge Infrastructure-CNKI and Wan Fang) were electronically searched to select relevant studies for this meta-analysis. We selected 95 case-control studies investigating 5 genes (MTHFR, AGT, F5, IL-10, and LEPR) with 8 SNPs...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27339100/genetic-polymorphisms-of-il-17a-il-17f-tlr4-and-mir-146a-in-association-with-the-risk-of-pulmonary-tuberculosis
#20
Min Wang, Guisheng Xu, Lingshuang Lü, Kun Xu, Yongzhong Chen, Hongqiu Pan, Bo Burstrom, Kristina Burstrom, Jianming Wang
Genetic factors affect host susceptibility to pathogens. In this population-based case control study, we explored the genetic polymorphisms of IL-17, TLR4 and miR-146a in association with pulmonary tuberculosis in a Chinese Han population. We recruited 1601 pulmonary tuberculosis patients matched with 1526 healthy controls and genotyped twelve functional single nucleotide polymorphisms (SNPs). After the correction for multiple comparisons, two SNPs (rs10759932 and rs2737190) in the TLR4 gene remained significant...
2016: Scientific Reports
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