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IL-17 gene polymorphism

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https://www.readbyqxmd.com/read/28526808/the-impact-of-interleukin-10-il-10-gene-4-polymorphisms-on-peripheral-blood-il-10-variation-and-prostate-cancer-risk-based-on-published-studies
#1
Tingting Men, Cuicui Yu, Dan Wang, Fang Liu, Jingjing Li, Xiaoying Qi, Chunhua Yang, Wenguo Jiang, Xiaodan Wei, Xuri Li, Bin Wang, Jia Mi, Geng Tian
This study purported to investigate the impact of interleukin-10 (IL-10) gene 4 polymorphisms (-1082G>A, -819T>C, -592A>C and 210T>C) on peripheral blood IL-10 variation and prostate cancer (PCa) risk, with a special consideration given to various origins of between-study heterogeneity. 2 researchers independently fulfilled literature retrieval, quality assessment and information collection. Sub-grouped analyses per ethnicity, continent, design type, control source, genotyping procedure, genotype validation, age-matched status, study sample size, quality score and controls' mean age were conducted, respectively...
April 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28512631/genetic-alterations-in-gastric-cancer-associated-with-helicobacter-pylori-infection
#2
REVIEW
Claudia I Rivas-Ortiz, Yolanda Lopez-Vidal, Luis Jose Rene Arredondo-Hernandez, Gonzalo Castillo-Rojas
Gastric cancer is a world health problem and depicts the fourth leading mortality cause from malignancy in Mexico. Causation of gastric cancer is not only due to the combined effects of environmental factors and genetic variants. Recent molecular studies have transgressed a number of genes involved in gastric carcinogenesis. The aim of this review is to understand the recent basics of gene expression in the development of the process of gastric carcinogenesis. Genetic variants, polymorphisms, desoxyribonucleic acid methylation, and genes involved in mediating inflammation have been associated with the development of gastric carcinogenesis...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28481151/association-between-snps-at-il-17a-and-il-17f-and-susceptibility-to-accelerated-silicosis
#3
Ebrahim Hassani, Morteza Bagheri, Isa Abdi Rad, Iraj Mohebbi
The association between single nucleotide polymorphisms (SNPs) in the interleukin (IL)-17 gene and silicosis has been evaluated in different populations. The aim of the present study was to analyze the association between SNPs at IL-17A (-832A/G) and IL-17F (+7488A/G) and susceptibility to accelerated silicosis in the Iranian Kurdish population. We studied 48 patients with accelerated silicosis and 62 controls. Genomic DNA was isolated using the "salting out" method. PCR-RFLP was performed for all SNPs typing...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28457029/role-of-ace-and-il-1%C3%AE-gene-polymorphisms-in-erythropoeitin-hyporesponsive-patients-with-chronic-kidney-disease-with-anemia
#4
N Nand, A R Deshmukh, S Joshi, M P Sachdeva, Sakthivel
BACKGROUND: Hyporesponse to erythropoietin is a common problem seen in around 5-10% of patients. Recently the focus from these remediable factors has been shifted to the non-modifiable innate factors i.e polymorphism of ACE and IL-1B gene and studies have shown that DD genotype and IL-1B CC genotype have lower erythropoietin requirement. The aim of our study was to evaluate the role of ACE and IL-1B gene polymorphisms in erythropoietin hyporesponse in CKD patients with anemia. METHODS: A total of 50 patients were selected...
February 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28444425/pharmacogenetic-markers-to-predict-the-clinical-response-to-methotrexate-in-south-indian-tamil-patients-with-psoriasis
#5
S Indhumathi, Medha Rajappa, Laxmisha Chandrashekar, P H Ananthanarayanan, D M Thappa, V S Negi
INTRODUCTION: Despite the advent of several new systemic therapies, methotrexate remains the gold standard for the treatment of moderate to severe psoriasis. However, there exists a significant heterogeneity in individual response to methotrexate. There are no consistently reliable markers to predict methotrexate treatment response till date. OBJECTIVES: We aimed to demonstrate the association of certain genetic variants in the HLA (HLA-A2, HLA-B17, and HLA-Cw6) and the non-HLA genes including T-helper (Th)-1, Th-2, Th-17 cytokine genes (IFN-γ, IL-2, IL-4, IL-10, IL-12B, and IL-23R), and T-regulatory gene (FOXP3) with the methotrexate treatment response in South Indian Tamil patients with psoriasis...
April 25, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28410448/il17a-polymorphism-is-not-associated-with-human-t-lymphotropic-virus-1-associated-myelopathy-tropical-spastic-paraparesis
#6
Heytor V P C Neco, Vanessa G S Teixeira, Ana C L Trindade, Paula M R Magalhães, Virgínia M B Lorena, Luydson R Vasconcelos, Patricia M M F Moura, Clarice N L Morais
The human T-lymphotropic virus 1 (HTLV-1) is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The present study investigated the association between the rs2275913 polymorphism in the IL17A gene and the development of HAM/TSP. Peripheral blood samples were collected from 116 patients (29 symptomatic patients with HAM/TSP and 87 asymptomatic) with a positive diagnosis of HTLV-1. The single nucleotide polymorphism genotyping was carried out by real time quantitative PCR (RT-qPCR) using TaqMan(®) probes...
May 2017: Viral Immunology
https://www.readbyqxmd.com/read/28362993/association-between-interleukin-17-gene-polymorphisms-and-the-risk-of-laryngeal-cancer-in-a-chinese-population
#7
F Z Si, Y Q Feng, M Han
IL-17 is associated with the occurrence and development of laryngeal cancer. However, no study has reported the association between IL-17 polymorphisms and laryngeal cancer susceptibility. Therefore, we analyzed the association of three polymorphism loci (rs2275913, 197 G/A; rs3748067, 383 A/G; and rs763780, 7488 T/C) of IL-17A and IL-17F with laryngeal cancer in the Chinese population. A case-control study was performed with 325 patients and 325 controls. Polymorphisms were detected by polymerase chain reaction and sequencing methods...
March 30, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28327786/polymorphisms-in-genes-tlr1-2-and-4-are-associated-with-differential-cytokine-and-chemokine-serum-production-in-patients-with-leprosy
#8
Nadja de Lima Santana, Jamile Leão Rêgo, Joyce Moura Oliveira, Lucas Frederico de Almeida, Marcos Braz, Lídia Maria Medeiros Machado, Paulo Roberto Lima Machado, Léa Cristina Castellucci
BACKGROUND: Leprosy or hansen's disease is a spectral disease whose clinical forms mostly depends on host's immune and genetic factors. Different Toll-like receptors (TLR) variants have been described associated with leprosy, but with some lack of replication across different populations. OBJECTIVES: To evaluate the role of polymorphisms in genes TLR1, TLR2 and TLR4 and susceptibility to leprosy in a genetic case control study; to verify the association between genotypes of these markers and the immunological profile in the serum of patients with leprosy...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28298812/association-between-interleukin-10-1082-g-a-and-tumor-necrosis-factor-%C3%AE-308-g-a-gene-polymorphisms-and-respiratory-distress-syndrome-in-iranian-preterm-infants
#9
Abolfazl Khoshdel, Soleiman Kheiri, Peyman Omidvari, Fahimeh Moradi, Majid Hamidi, Hossein Teimori
Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. The present study was done to investigate the frequency of interleukin- (IL-) 10 and tumor necrosis factor- (TNF-) α gene polymorphisms and their association with the risk of RDS in preterm infants. One-hundred and nineteen patients with RDS and 119 healthy preterm infants were enrolled. PCR restriction fragment length polymorphism was used to determine the frequency of IL-10 and TNF-α genotypes at -1082 A and -308 A, respectively...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28296724/meta-analysis-of-the-role-of-il-6-rs1800795-polymorphism-in-the-susceptibility-to-prostate-cancer-evidence-based-on-17-studies
#10
Tong-Zu Liu, Zhong-Qiang Guo, Ting Wang, Yue Cao, Di Huang, Xing-Huan Wang
Playing critical roles in immune responses, interleukin-6 (IL-6) has been proposed to be involved in the development of multiple cancers, including prostate cancer. The rs1800795 polymorphism in the promoter of the gene IL-6 can affect the transcription and expression of the gene, becoming a common target in association studies on tumors. We therefore carried out this meta-analysis to further discuss the relationship of this polymorphism with the risk of prostate cancer.Relevant publications were retrieved from the electronic databases...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28289409/mitochondrial-dna-activates-the-nlrp3-inflammasome-and-predisposes-to-type-1-diabetes-in-murine-model
#11
Daniela Carlos, Frederico R C Costa, Camila A Pereira, Fernanda A Rocha, Juliana N U Yaochite, Gabriela G Oliveira, Fernando S Carneiro, Rita C Tostes, Simone G Ramos, Dario S Zamboni, Niels O S Camara, Bernhard Ryffel, João S Silva
Although a correlation between polymorphisms of NOD-like receptor family-pyrin domain containing 3 (NLRP3) and predisposition to type 1 diabetes (T1D) has been identified, the potential function and activation of the NLRP3 inflammasome in T1D have not been clarified. The present study shows that non-obese diabetic mice exhibited increased NLRP3, and pro-IL-1β gene expression in pancreatic lymph nodes (PLNs). Similar increases in gene expression of NLRP3, apoptosis associated speck like protein (ASC) and pro-IL-1β were induced by multiple low doses of streptozotocin (STZ) in C57BL/6 mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28277785/polymorphisms-in-the-il-17-gene-rs2275913-and-rs763780-are-associated-with-hepatitis-b-virus-infection-in-the-han-chinese-population
#12
Wei Ren, Zehua Wu, Ruixin Ma, Zhen Liu, Yingying Wang, Liqun Wu, Shiguo Liu, Zusen Wang
AIM: Interleukin-17 (IL-17) can accelerate the release of many pro-inflammatory cytokines. The purpose of our study was to investigate the potential association between polymorphisms in the IL-17 gene and susceptibility to hepatitis B virus (HBV) infection in the Han Chinese population. METHODS: We recruited 596 HBV-infected patients and 612 ethnically matched controls, who were then genotyped for the IL-17A and IL-17F polymorphisms, rs2275913 and rs763780, respectively, by using TaqMan probe-based real-time polymerase chain reaction...
May 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28225209/association-of-the-il-10-receptor-a536g-s138g-loss-of-function-variant-with-multiple-sclerosis-in-tunisian-patients
#13
Nadia Ben Fredj, Mouna Aissi, Walid Ben Selma, Imen Mahmoud, Faten Nefzi, Mahbouba Frih-Ayed, Jalel Boukadida, Mahjoub Aouni
Interleukin-10 (IL-10), a potent anti-inflammatory T-cell cytokine, has been shown to be a regulatory cytokine that is associated with disease remission in multiple sclerosis (MS) and exerts its activity through its cognate cell surface receptor complex, IL-10 receptor 1 (IL-10R1) and IL-10R2. The purpose of this study was to investigate the IL-10R1 S138G loss-of-function polymorphism (A536G: rs3135932) for possible influence on susceptibility and outcome of MS in Tunisian patients. A total of 103 Tunisian MS patients and 160 control subjects were studied...
February 22, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28212655/elderly-onset-hereditary-pulmonary-alveolar-proteinosis-and-its-cytokine-profile
#14
Masayuki Ito, Kazuyuki Nakagome, Hiromitsu Ohta, Keiichi Akasaka, Yoshitaka Uchida, Atsushi Hashimoto, Ayako Shiono, Toshinori Takada, Makoto Nagata, Jun Tohyama, Koichi Hagiwara, Minoru Kanazawa, Koh Nakata, Ryushi Tazawa
BACKGROUND: Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by surfactant accumulation, and is caused by disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. Abnormalities in CSF2 receptor alpha (CSF2RA) were reported to cause pediatric hereditary PAP. We report here the first case of CSF2RA-mutated, elderly-onset hereditary (h) PAP. CASE PRESENTATION: The patient developed dyspnea on exertion, and was diagnosed with PAP at the age of 77 years, based on findings from chest computed tomography scan and bronchoalveolar lavage...
February 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28167095/genome-wide-interaction-study-of-dust-mite-allergen-on-lung-function-in-children-with-asthma
#15
Erick Forno, Joanne Sordillo, John Brehm, Wei Chen, Takis Benos, Qi Yan, Lydiana Avila, Manuel Soto-Quirós, Michelle M Cloutier, Angel Colón-Semidey, Maria Alvarez, Edna Acosta-Pérez, Scott T Weiss, Augusto A Litonjua, Glorisa Canino, Juan C Celedón
BACKGROUND: Childhood asthma is likely the result of gene-by-environment (G × E) interactions. Dust mite is a known risk factor for asthma morbidity. Yet, there have been no genome-wide G × E studies of dust mite allergen on asthma-related phenotypes. OBJECTIVE: We sought to identify genetic variants whose effects on lung function in children with asthma are modified by the level of dust mite allergen exposure. METHODS: A genome-wide interaction analysis of dust mite allergen level and lung function was performed in a cohort of Puerto Rican children with asthma (Puerto Rico Genetics of Asthma and Lifestyle [PRGOAL])...
February 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28148965/rapid-detection-of-functional-gene-polymorphisms-of-tlrs-and-il-17-using-high-resolution-melting-analysis
#16
Johanna Teräsjärvi, Antti Hakanen, Matti Korppi, Kirsi Nuolivirta, Kirsi Gröndahl-Yli-Hannuksela, Jussi Mertsola, Ville Peltola, Qiushui He
Genetic variations in toll-like receptors (TLRs) and IL-17A have been widely connected to different diseases. Associations between susceptibility and resistance to different infections and single nucleotide polymorphisms (SNPs) in TLR1 to TLR4 and IL17A have been found. In this study, we aimed to develop a rapid and high throughput method to detect functional SNPs of above mentioned proteins. The following most studied and clinically important SNPs: TLR1 (rs5743618), TLR2 (rs5743708), TLR3 (rs3775291), TLR4 (rs4986790) and IL17 (rs2275913) were tested...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28143790/association-of-il17a-and-il17f-genes-with-rheumatoid-arthritis-disease-and-the-impact-of-genetic-polymorphisms-on-response-to-treatment
#17
Ouled Salah Marwa, Tizaoui Kalthoum, Kaabachi Wajih, Hamzaoui Kamel
BACKGROUND: Previous studies have reported an association between polymorphisms in Il17A and IL17F genes and the prevalence of rheumatoid arthritis (RA) in Caucasian populations. The aim of the current study was to investigate that polymorphisms in both genes may affect RA susceptibility in the Tunisian population and to study the relation between serum IL-17 levels and synovial fluid (SF) levels and risk in RA patients. We suggested also that these polymorphisms may influence response to treatment in Tunisian RA patients...
March 2017: Immunology Letters
https://www.readbyqxmd.com/read/28112181/il-3-and-ctla4-gene-polymorphisms-may-influence-the-tacrolimus-dose-requirement-in-chinese-kidney-transplant-recipients
#18
Mou-Ze Liu, Hai-Yan He, Yue-Li Zhang, Yong-Fang Hu, Fa-Zhong He, Jian-Quan Luo, Zhi-Ying Luo, Xiao-Ping Chen, Zhao-Qian Liu, Hong-Hao Zhou, Ming-Jie Shao, Ying-Zi Ming, Hua-Wen Xin, Wei Zhang
The highly variable pharmacokinetics and narrow therapeutic window of tacrolimus (TAC) has hampered its clinical use. Genetic polymorphisms may contribute to the variable response, but the evidence is not compelling, and the explanation is unclear. In this study we attempted to find previously unknown genetic factors that may influence the TAC dose requirements. The association of 105 pathway-related single nucleotide polymorphisms (SNPs) with TAC dose-adjusted concentrations (C0/D) was examined at 7, 30 and 90 d post-operation in 382 Chinese kidney transplant recipients...
March 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28103273/association-between-genetic-polymorphisms-in-interleukin-genes-and-recurrent-pregnancy-loss-a-systematic-review-and-meta-analysis
#19
Meixiang Zhang, Jiawei Xu, Xiao Bao, Wenbin Niu, Linlin Wang, Linqing Du, Nan Zhang, Yingpu Sun
Interleukins are a group of immunomodulatory proteins that mediate a variety of immune reactions in the human body. To investigate the association between interleukin gene polymorphisms and recurrent pregnancy loss (RPL), we reviewed 21 studies from MEDLINE, EMBASE, OVID SP and PubMed to evaluate RPL-related interleukin gene polymorphisms. Meta-analysis was performed on 12 of the polymorphisms, and a review included the others. Our integrated results indicated that IL-1β (-511C/T) (P = 0.02, 95% CI 0.77[0...
2017: PloS One
https://www.readbyqxmd.com/read/28101335/novel-snps-in-il-17f-and-il-17a-genes-associated-with-somatic-cell-count-in-chinese-holstein-and-inner-mongolia-sanhe-cattle
#20
Tahir Usman, Yachun Wang, Chao Liu, Yanghua He, Xiao Wang, Yichun Dong, Hongjun Wu, Airong Liu, Ying Yu
BACKGROUND: Bovine mastitis is the most common and costly disease of lactating cattle worldwide. Apart from milk somatic cell count (SCC) and somatic cell score (SCS), serum cytokines such as interleukin-17 (IL-17) and interleukin-4 (IL-4) may also be potential indicators for bovine mastitis. The present study was designed to investigate the effects of single nucleotide polymorphisms (SNPs) in bovine IL-17F and IL-17A genes on SCC, SCS and serum cytokines in Chinese Holstein and Inner-Mongolia Sanhe cattle, and to compare the mRNA expression variations of the cows with different genotypes...
2017: Journal of Animal Science and Biotechnology
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