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IL-17 gene polymorphism

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https://www.readbyqxmd.com/read/29656314/-174-g-c-il-6-polymorphism-and-primary-iron-overload-in-male-patients
#1
Walter F Tetzlaff, Tomás Meroño, Eliana E Botta, Maximiliano E Martín, Patricia B Sorroche, Laura E Boero, Marcelo Castro, Gustavo D Frechtel, Jorge Rey, Jorge Daruich, Gloria E Cerrone, Fernando Brites
Primary iron overload (IO) is commonly associated with mutations in the hereditary hemochromatosis gene (HFE). Nonetheless, other genetic variants may influence the development of IO beyond HFE mutations. There is a single nucleotide polymorphism (SNP) at - 174 G>C of the interleukin (IL)-6 gene which might be associated with primary IO. Our aim was to study the association between the SNP - 174 G>C gene promoter of IL-6 and primary IO in middle-aged male patients. We studied 37 men with primary IO diagnosed by liver histology...
April 14, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29621504/interleukin10-1082-a-g-polymorphism-allele-frequency-correlation-with-disease-markers-messenger-rna-and-serum-levels-in-north-indian-rheumatoid-arthritis-patients
#2
Mohd Jahid, Rehan-Ul-Haq, Rajnish Avasthi, Rafat Sultana Ahmed
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder of unknown etiology. IL-10 stimulates B cell survival and is involved in antibody isotype switching. The serum IL-10 levels are increased in RA patients. Ethnicity influences polymorphisms in cytokine genes. Therefore, this study was designed to explore possible association, if any, between polymorphism of IL10-1082 A/G, serum cytokine levels, inflammatory markers and gene expression in RA patients of North India...
April 2, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29603203/association-of-interleukin-22-gene-polymorphisms-and-serum-il-22-level-with-risk-of-systemic-lupus-erythematosus-in-a-chinese-population
#3
Rong Wang, Yong-Long Zeng, Hai-Mei Qin, Yu-Lan Lu, Hua-Tuo Huang, Ming Lei, Tan Tan, Yan-Yun Huang, Hong-Cheng Luo, Yan Lan, Ye-Sheng Wei
The aim of this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) of interleukin 22 (IL-22) gene and systemic lupus erythematosus (SLE) in a Chinese population. Three IL-22 SNPs (rs2227485, rs2227513 and rs2227491) were genotyped using Snapshot SNP genotyping assays and identified by sequencing in 314 SLE patients and 411 healthy controls. IL-22 level of serum was assessed by enzyme-linked immunosorbent assay (ELISA) kits. Data were analyzed by SPSS 17.0 software. We found that rs2227513 was associated with an increased risk of SLE (AG vs...
March 30, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29584788/il-17a-il-17rc-polymorphisms-and-il17-plasma-levels-in-tunisian-patients-with-rheumatoid-arthritis
#4
Tarak Dhaouadi, Mayssa Chahbi, Youssra Haouami, Imen Sfar, Leila Abdelmoula, Taieb Ben Abdallah, Yousr Gorgi
BACKGROUND: Interleukin-17 (IL-17), a cytokine mainly secreted by Th17 cells, seems to play a significant role in the pathogenesis of rheumatoid arthritis (RA). Functional genetic polymorphisms in IL-17 and its receptor genes can influence either qualitatively or quantitatively their functions. Therefore, we aimed to study the impact of IL17-A and IL17RC polymorphisms on plasma level of IL-17 and RA susceptibility and severity. METHODS: In this context, IL-17A*rs2275913 and IL-17RC*rs708567 polymorphisms were investigated together with the quantification of IL17 plasma level in 115 RA patients and 91 healthy control subjects matched in age, sex and ethnic origin...
2018: PloS One
https://www.readbyqxmd.com/read/29564064/genetic-association-between-a-single-nucleotide-polymorphism-in-interleukin-16-rs4072111-and-susceptibility-to-chronic-hcv-infection-in-an-iranian-population
#5
Maryam Karkhane, Seyed Reza Mohebbi, Pedram Azimzadeh, Hasti Avarandeh, Shabnam Kazemian, Afsaneh Sharifian, Behzad Hatami, Hamid Asadzadeh Aghdaei
Aim: Our goal was to identify the putative association of rs4072111 variant in IL-16 gene and HCV susceptibility in an Iranian population. Background: Interleukin 16 (IL-16), a multifunctional cytokine, plays a vital role in modulation of immune system. Methods: In present case control and cross sectional study, IL-16 gene variant in 300 patients with hepatitis C (HCV) infection and 300 healthy individuals were analyzed. To evaluate this possible association, genomic DNA from venous blood was extracted and genotypes of IL-16 rs4072111 variant were determined by polymerase chain reaction- Fragments Length Polymorphism Technique (PCR-RFLP)...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29552315/meta-analysis-of-the-relationship-between-single-nucleotide-polymorphism-of-il-10-1082g-a-and-rheumatic-heart-disease
#6
Weiran Dai, Ziliang Ye, Haili Lu, Qiang Su, Hui Li, Lang Li
Background: The results showed that there was a certain correlation between the single nucleotide polymorphism of IL-10-1082G/A and rheumatic heart disease, but there was no systematic study to verify this conclusion. Aims: Systematic review of the association between single nucleotide polymorphism of IL-10-1082G/A locus and rheumatic heart disease. Materials and Methods: Computer retrieval PubMed, EMbase, Cochrane Library, CBM, CNKI, VIP and Data WanFang, the retrieval time limit from inception to June 2017...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29530464/role-of-gene-polymorphisms-haplotypes-and-serum-levels-of-interleukin-17a-in-susceptibility-to-viral-myocarditis
#7
Hui Tang, Hua Pei, Qianfeng Xia, Yimei Tang, Ji Huang, Jie Huang, Fang Pei
Interleukin-17A (IL-17A) has been implicated in the pathogenesis of viral myocarditis (VMC). However, the role of IL-17A polymorphisms in susceptibility to VMC has not been reported to date. The aim of this study was to explore the association between IL-17A variants as well as serum IL-17 levels with VMC. Three single-nucleotide polymorphisms (SNPs) (rs2275913, rs3819025, and rs3748067) were analyzed by the polymerase chain reaction-restriction fragment length polymorphism method in 236 VMC patients and 259 controls from China...
March 9, 2018: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29502070/association-of-genetic-variations-in-ptpn2-and-cd122-with-ocular-behcet-s-disease
#8
Qi Zhang, Hua Li, Shengping Hou, Hongsong Yu, Guannan Su, Bolin Deng, Jian Qi, Chunjiang Zhou, Aize Kijlstra, Peizeng Yang
BACKGROUND: Protein tyrosine phosphatases (PTPs) play critical roles in human autoimmunity. Previous studies found that PTPN2 may be the key regulatory factor in the T-cell-mediated immune response. PTPN2 regulates the Janus kinase/signal transducers and activators of transcription pathway by inhibiting signalling via the interleukin (IL)-2 receptor (CD122). An association between genetic variations in PTPN2 and CD122 with ocular Behcet's disease (BD) has not yet been addressed and was therefore the purpose of this study...
March 3, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29497450/analysis-of-interleukin-10-gene-polymorphisms-in-patients-with-chronic-periodontitis-and-healthy-controls
#9
Bita Moudi, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Mehrnoosh Moudi
Background: Interleukin-10 (IL-10) is an anti-inflammatory cytokine that has important roles in the periodontal diseases. The IL10-1082, -819, and -592 polymorphisms in the promoter region of IL-10 gene have been associated with various IL-10 expressions. The aim of this study was to investigate the association between these gene polymorphisms with chronic periodontitis in a sample of Iranian populations from Southeast of Iran. Materials and Methods: IL-10 single nucleotide polymorphisms were analyzed in 210 patients with chronic periodontitis (CP) and 100 individuals without CP by polymerase chain reaction-restriction fragment length polymorphism method...
January 2018: Dental Research Journal
https://www.readbyqxmd.com/read/29479509/enrichment-of-genomic-resources-and-identification-of-simple-sequence-repeats-from-medicinally-important-clausena-excavata
#10
Doo Young Bae, Sang Mi Eum, Sang Woo Lee, Jin-Hyub Paik, Soo-Yong Kim, Mihyun Park, Changyoung Lee, The Bach Tran, Van Hai Do, Jae-Yun Heo, Eun-Soo Seong, Il-Seop Kim, Ki-Young Choi, Jin Sung Hong, Rahul Vasudeo Ramekar, Sangho Choi, Jong-Kuk Na
To broaden and delve into the genomic information of Clausena excavata , an important medicinal plant in many Asian countries, RNA sequencing (RNA-seq) analysis was performed and a total of 16,638 non-redundant unigenes (≥ 300 bp) with an average length of 755 bp were generated by de novo assembly from 17,580,456 trimmed clear reads. The functional categorization of the identified unigenes by a gene ontology (GO) term resulted in 2305 genes in the cellular component, 5577 in the biological processes, and 8056 in the molecular functions, respectively...
March 2018: 3 Biotech
https://www.readbyqxmd.com/read/29462797/functional-snp-in-the-3-utr-of-pon1-is-associated-with-the-risk-of-calcific-aortic-valve-stenosis-via-mir-616
#11
Zhengjun Wang, Shiqiao Chen, Mei Zhu, Wenlong Zhang, Haizhou Zhang, Hongxin Li, Chengwei Zou
BACKGROUND/AIMS: Previous studies have examined the associations between the single nucleotide polymorphism in the Paraoxonase 1 (PON1) gene and development of calcific aortic valve stenosis (CAVS). The association between functional SNP in 3'UTR of PON1 and the risk of CAVS, however, is unclear. In this study, we investigated the role of SNP in the regulation of PON1 expression via miR-616, as well as the association of SNP with the risk of CAVS. METHODS: Two hundred and sixteen patients with CAVS and 243 CAVS-free participants were recruited in this study...
February 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29407292/impact-of-interleukin-17f-gene-polymorphisms-in-outcome-of-kidney-transplantation-in-tunisian-recipients
#12
Y Haouami, I Sfar, T Dhaouadi, T Gargah, M Bacha, R Bardi, E Abderrahim, R Goucha, M Ounissi, T Ben Abdallah, Y Gorgi
BACKGROUND: Genetic polymorphisms of interleukin (IL)-17F, associated with functional and/or quantitative change in this glycoprotein, have been described as predisposing to various autoimmune diseases. The proinflammatory IL-17 has some roles in renal transplantation. In this context, the relationship between the most common IL-17F polymorphisms with acute renal allograft rejection susceptibility in Tunisian renal recipients has been investigated. METHODS: We examined 93 renal transplant recipients who were enrolled and classified as follows: GI, 48 transplant recipients who developed at least one episode of acute rejection; and GII, 45 controls, kidney recipients who also were followed for at least 1 year and had stable renal function...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29400002/interleukin-2-16-and-17-gene-polymorphisms-in-iranian-patients-with-chronic-periodontitis
#13
Surena Vahabi, Bahareh Nazemisalman, Sepanta Hosseinpour, Simindokht Salavitabar, Alireza Aziz
AIM: Chronic periodontitis (CP) is a multifactorial disease and the most common type of periodontitis mainly caused by microbial plaque. CP can be brought on by, and progresses with, insufficient oral hygiene, and environmental and genetic susceptibilities. The aim of the present study was to investigate the association between interleukin (IL)-2 (T-330G), IL-16 (T-295C), and IL-17 (A-7383G) gene polymorphisms and the susceptibility to CP in an Iranian population. METHODS: Ninety-nine cases diagnosed with CP and 75 matched healthy controls engaged in the present study...
February 5, 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29345518/bacterial-pathogenesis-and-interleukin-17-interconnecting-mechanisms-of-immune-regulation-host-genetics-and-microbial-virulence-that-influence-severity-of-infection
#14
Michelle N Chamoun, Antje Blumenthal, Matthew J Sullivan, Mark A Schembri, Glen C Ulett
Interleukin-17 (IL-17) is a pro-inflammatory cytokine involved in the control of many different disorders, including autoimmune, oncogenic, and diverse infectious diseases. In the context of infectious diseases, IL-17 protects the host against various classes of microorganisms but, intriguingly, can also exacerbate the severity of some infections. The regulation of IL-17 expression stems, in part, from the activity of Interleukin-23 (IL-23), which drives the maturation of different classes of IL-17-producing cells that can alter the course of infection...
January 18, 2018: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/29333402/interleukin-1b-il-1b-31-and-il-1b-511-and-interleukin-1-receptor-antagonist-il-1ra-gene-polymorphisms-in-primary-immune-thrombocytopenia
#15
Deependra Kumar Yadav, Anil Kumar Tripathi, Divya Gupta, Saurabh Shukla, Aloukick Kumar Singh, Ashutosh Kumar, Jyotsna Agarwal, K N Prasad
Background: Immune thrombocytopenia (ITP) is an immune-mediated disease caused by autoantibodies against platelets membrane glycoproteins GPIIb/IIIa and GPIb/IX. The etiology of ITP remains unclear. This study evaluated the association of polymorphisms in interleukin ( IL ) -1B-31 , IL-1B-511 , and IL-1Ra with ITP. Methods: Genotyping of IL-1B-31 , IL-1B-511 , and IL-1Ra was performed in 118 ITP patients and 100 controls by polymerase chain reaction restriction fragment length polymorphism and detection of variable number tandem repeats...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29305046/proinflammatory-biomarkers-level-and-functional-genetic-polymorphisms-in-periprosthetic-joint-infection
#16
Bülent Erdemli, Emre Anıl Özbek, Kerem Başarir, Zeynep Ceren Karahan, Duygu Öcal, Derya Biriken
OBJECTIVE: The aims of this study were 1) to identify the level of inflammatory biomarkers interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-17, C-reactive protein (CRP), granulocyte colony-stimulating factor (GCSF), ferritin, and tumor necrosis factor (TNF)-α in serum and synovial fluid samples of patients who underwent revision arthroplasty surgery; 2) to establish the relationship between serum and synovial fluid levels; 3) to determine if any of the 11 genetic polymorphisms of TNFα, IL-1, IL-6, IL-8, IL-17, and GCSF on the encoding genes was associated with periprosthetic joint infection (PJI)...
January 2, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29199606/association-of-il-6-597-g-a-polymorphism-with-cancer-risk-evidence-from-a-meta-analysis
#17
Dingliang Qian, Shaorong Yan, Xiaowei Pan
Although it has been suggested that the interleukin-6(IL-6) gene -597G/A polymorphism may be a risk factor for cancer, the conclusions from previous studies are inconsistent. To clarify the precise interrelation, we performed a comprehensive meta-analysis of 6 case-control studies involving 1,605 subjects (706 cases and 899 controls). The overall results showed no significant association between the IL6 -597G/A polymorphism and cancer risk in the overall population (CC vs GG: OR = 2.38, 95% CI = 0.62-9.14; CG vs GG: OR = 1...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29190601/cytokine-gene-polymorphism-in-children-with-idiopathic-nephrotic-syndrome
#18
Dina Abdel Razek Midan, Nesreen Gamal Elhelbawy, Mona Salah El-Din Habib, Iman Aly Ahmedy, Rasha Ibrahim Noreldin
INTRODUCTION: Idiopathic nephrotic syndrome (INS) is a glomerular disease with completely unclear pathogenesis and different responses to steroid therapy. This study aimed to investigate the role of cytokine genes promoter polymorphisms in steroid therapy responses. MATERIALS AND METHODS: One hundred children with INS and 30 healthy controls were studied. Genotyping of TNF-α-G308A single nucleotide polymorphism was done using polymerase chain reaction-restriction fragment length polymorphism method, while of IL-6-G174C single nucleotide polymorphism was done using real-time polymerase chain reaction...
November 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29110844/genetic-polymorphisms-and-lung-cancer-risk-evidence-from-meta-analyses-and-genome-wide-association-studies
#19
REVIEW
Caiyang Liu, Huijie Cui, Dongqing Gu, Min Zhang, Yanfei Fang, Siyu Chen, Mingshuang Tang, Ben Zhang, Huanwen Chen
A growing number of studies investigating the association between Single Nucleotide Polymorphisms (SNPs) and lung cancer risk have been published since over a decade ago. An updated integrative assessment on the credibility and strength of the associations is required. We searched PubMed, Medline, and Web of Science on or before August 29(th), 2016. A total of 198 articles were deemed eligible for inclusion, which addressed the associations between 108 variants and lung cancer. Among the 108 variants, 63 were reported to be significantly associated with lung cancer while the remaining 45 were reported non-significant...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29108239/interactions-between-vitamin-d-receptor-vdr-gene-and-interleukin-6-gene-and-environment-factors-on-coronary-heart-disease-risk-in-a-chinese-han-population
#20
Ma Jun, Guan Xue-Qiang, Li Jia, Xue Yang-Jing, Zheng Cheng, Jin Ge
Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within Interleukin-6 ( IL- 6 ) and vitamin D receptor ( VDR ) gene, and additional gene- gene and gene- smoking interaction with coronary heart disease (CHD) risk in a Chinese population. Methods: Hardy-Weinberg equilibrium (HWE) examination was used by SNPstats (http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking...
October 3, 2017: Oncotarget
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