keyword
MENU ▼
Read by QxMD icon Read
search

IL-17 gene polymorphism

keyword
https://www.readbyqxmd.com/read/28069745/associations-between-circulating-il-17-levels-and-rheumatoid-arthritis-and-between-il-17-gene-polymorphisms-and-disease-susceptibility-a-meta-analysis
#1
Young Ho Lee, Sang-Cheol Bae
OBJECTIVES: To systematically review evidence regarding the relationship between circulating interleukin-17 (IL-17) levels and rheumatoid arthritis (RA), and associations between polymorphisms in IL-17 genes and RA susceptibility. METHOD: We performed a meta-analysis of serum/plasma IL-17 levels in patients with RA and controls, and evaluated evidence of associations between the rs2275913, rs3819024, rs4711998 and rs8193036 polymorphisms in IL-17A and the rs763780 and rs2397084 polymorphisms in IL-17F and risk for RA...
January 9, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28053319/pre-diagnostic-genotyping-identifies-t1d-subjects-with-impaired-treg-il-2-signaling-and-an-elevated-proportion-of-foxp3-il-17-cells
#2
A K Marwaha, C Panagiotopoulos, C M Biggs, S Staiger, K L Del Bel, A F Hirschfeld, J J Priatel, S E Turvey, R Tan
T-regulatory cells (Tregs) are essential for immune tolerance, and animal studies implicate their dysfunction in type 1 diabetes (T1D) pathogenesis. Tregs require interleukin-2 (IL-2) for their suppressive function, and variants in IL-2/IL-2R pathway genes have been associated with T1D. We previously reported that recent-onset T1D subjects have an increased population of FOXP3(lo) Tregs that secrete the pro-inflammatory cytokine, interleukin-17 (IL-17). We hypothesize that IL-2 signaling defects may drive T1D development by skewing protective Tregs towards an inflammatory Th17 phenotype...
January 5, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/28043521/interleukin-10-gene-polymorphism-is-associated-with-multi-drug-resistant-tuberculosis-during-the-intensive-phase-of-standard-chemotherapy
#3
Butov Dmytro, Kuzhko Mykhailo, Butova Tetyana Kuzhko
OBJECTIVE/BACKGROUND: To study whether interleukin (IL)-10 gene polymorphism is associated with multi-drug resistant tuberculosis (MDR TB) during the intensive phase of standard chemotherapy. METHODS: The study comprised 170 individuals in Kharkiv region of Ukraine including 74 patients with pulmonary MDR TB (Group 1), 66 patients without MDR TB (Group 2), and 30 healthy donors (Group 3). Serum level of IL-10 was evaluated by enzyme-linked immunosorbent assay (pg/L)...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28027921/t-helper-2-cytokine-regulatory-t-cell-gene-polymorphisms-and-their-relation-with-risk-of-psoriasis-in-a-south-indian-tamil-cohort
#4
Sundar Indhumathi, Medha Rajappa, Laxmisha Chandrashekar, Palghat Hariharan Ananthanarayanan, Devinder Mohan Thappa, Vir Singh Negi
BACKGROUND: Psoriasis is known to be associated with an up-regulation of T-helper (Th)-1 & Th-17 cytokines and a relative down-regulation of Th-2 and T-regulatory (T-reg) cytokines. Certain allelic variants of these cytokine genes may alter Th1/Th17 and Th2/T-reg balance and may be associated with the risk of psoriasis. Hence we aimed to determine the association of IL-4 (rs2243250), IL-10 (rs1800871 and rs1800896) and FOXP3 (rs3761548) gene polymorphisms with risk of psoriasis in South Indian Tamils...
December 24, 2016: Human Immunology
https://www.readbyqxmd.com/read/28012172/mhc-class-ii-alleles-associated-with-th1-rather-than-th17-type-immunity-drive-the-onset-of-early-arthritis-in-a-rat-model-of-rheumatoid-arthritis
#5
Jonatan Tuncel, Sabrina Haag, Rikard Holmdahl
Polymorphisms in the MHC class II (MHCII) genes are strongly associated with rheumatoid arthritis, supporting the importance of autoreactive T helper (Th) cells for the development of this disease. Here, we used pristane-induced arthritis (PIA), induced by the non-antigenic hydrocarbon pristane, to study the impact of different MHCII alleles on T-cell activation and differentiation. In MHCII-congenic rats with disease-promoting MHCII alleles, pristane primarily induced activation of Th1 cells, whereas activated T cells were Th17 biased in rats with protective MHCII alleles...
December 24, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/28002581/investigation-on-the-association-between-il-10-c819t-gene-polymorphisms-and-susceptibility-to-gastric-cancer
#6
L Li, X Y Tang, L M Ye, Q Yang, Y Li
We conducted a case-control study to investigate the association between the interleukin-10 (IL-10) C819T polymorphism and susceptibility to gastric cancer in a Chinese population. A total of 157 patients with gastric cancer and 249 controls were consecutively enrolled from the Guizhou Provincial People's Hospital between October 2012 and February 2015. The polymerase chain reaction-restriction fragment length polymorphism technique was used to genotype for IL-10 C819T. As determined by χ(2)-test, there was a significant difference in genotype distributions of IL-10 C819T between gastric cancer patients and controls (χ(2) = 7...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27890033/il-8-il-17-gene-variations-and-the-susceptibility-to-severe-viral-bronchiolitis
#7
L A Pinto, L A DE Azeredo Leitão, M Mocellin, P Acosta, M T Caballero, R Libster, J E Vargas, F Polack, T Comaru, R T Stein, A P DE Souza
Clinical manifestations of acute bronchiolitis (AB) vary from minimal disease to severe respiratory failure. The response to respiratory viral infections is possibly influenced by genetic polymorphisms linked to the regulation of the inflammatory response. In the present study, we investigated whether interleukin-8 (IL-8) and interleukin-17 (IL-17) genetic variants are associated with the severity of AB. A group of Brazilian infants hospitalized with AB and a control group (infants with no or mild AB, without hospitalization) were genotyped for four IL-8/IL-17 variations...
November 28, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27876593/intact-interferon-%C3%AE-response-against-coxiella-burnetii-by-peripheral-blood-mononuclear-cells-in-chronic-q-fever
#8
T Schoffelen, J Textoris, C P Bleeker-Rovers, A Ben Amara, J W M van der Meer, M G Netea, J-L Mege, M van Deuren, E van de Vosse
OBJECTIVES: Q fever is caused by Coxiella burnetii, an intracellular bacterium that infects phagocytes. The aim of the present study was to investigate whether the C. burnetii-induced IFN-γ response is defective in chronic Q fever patients. METHODS: IFN-γ was measured in supernatants of C. burnetii-stimulated peripheral blood mononuclear cells (PBMCs) of 17 chronic Q fever patients and 17 healthy individuals. To assess IFN-γ responses, expression profiles of IFN-γ-induced genes in C...
November 20, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27799970/polymorphism-of-il-28b-gene-rs12979860-in-hcv-genotype-1patients-treated-by-pegylated-interferon-and-ribavirin
#9
Fahimeh Safarnezhad Tameshkel, Mohammad Hadi Karbalaie Niya, Msuodreza Sohrabi, Mahshid Panahi, Farhad Zamani, Farid Imanzade, Nasser Rakhshani
BACKGROUND: Nowadays, the immune response to hepatitis C (HCV) treatment has become a crucial issue mostly due to the interleukin 28B (IL-28B) polymorphism effects in chronic HCV patients. The aim of this study was to detect the polymorphism of IL-28B gene (rs12979860) in HCV genotype 1 patients treated with pegylated Interferon and Ribavirin. METHODS: From the 2010 to 2012, a total of 115 peripheral blood mononuclear cells (PBMCs) of HCV patients who presented to Gastrointestinal & Liver Disease Research Center (GILDRC), Firoozgar Hospital, Tehran, Iran were enrolled in this retrospective cross sectional study...
2016: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/27785055/il-10-1082a-g-592c-a-and-819t-c-polymorphisms-in-association-with-lung-cancer-susceptibility-a-meta-analysis
#10
Liang Liu, Feng Zheng
Numerous studies have examined the association between interleukin-10 (IL-10 -1082A/G, -592C/A, and -819T/C) gene polymorphisms and risk of lung cancer, but these have revealed inconsistent results. The aim of this study was to clarify the relationship between these polymorphisms and the risk of lung cancer by performing a meta-analysis. The published literature concerning IL-10 polymorphisms and lung cancer risk were retrieved by systematically searching PubMed, Embase, Web of Science, China National Knowledge Infrastructure, WanFang, and Database of Chinese Scientific and Technical Periodicals (VIP) database...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27774581/a-preliminary-study-of-new-single-polymorphisms-in-the-t-helper-type-17-pathway-for-psoriasis-in-the-korean-population
#11
S Y Kim, M S Hur, B G Choi, M J Kim, Y W Lee, Y B Choe, K J Ahn
Psoriasis is a polygenic and multi-factorial disease showing ethnic differences in terms of its severity and frequency. Therapies targeting interleukin (IL)-17A, IL-17 receptor (IL-17R) and Janus kinases (JAKs) are in clinical development for the treatment of psoriasis, and their success suggests the essential role of these molecules in psoriasis. To investigate the genetic susceptibility in T helper type 17 (Th17) cell signal transduction pathways for promoting psoriasis, we performed candidate gene and linkage disequilibrium analysis...
February 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27722983/relationships-between-common-and-novel-interleukin-6-gene-polymorphisms-and-risk-of-cervical-cancer-a-case-control-study
#12
Sabrina Zidi, Mouna Stayoussef, Bano L Alsaleh, Ezzedine Gazouani, Amel Mezlini, Bashayer H Ebrahim, Besma Yacoubi-Loueslati, Wassim Y Almawi
We investigated the association between six common and novel interleukin-6 (IL-6) polymorphisms with the risk of cervical cancer (CC) among Tunisians. Study subjects comprised 112 CC cases and 164 control women. Genotyping of IL-6 rs2069845, rs2069840, rs1474348, rs1800795, rs1800797, rs2069827 variants was done by real-time PCR, with defined clusters. The allelic and genotypic distributions of the tested IL-6 SNPs were comparable between CC patients and control women. Stratification according to FIGO staging revealed that rs1800795 homozygous major allele genotype (P = 0...
October 8, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27706622/investigation-on-ercc5-genetic-polymorphisms-and-the-development-of-gastric-cancer-in-a-chinese-population
#13
L Q Yang, Y Zhang, H F Sun
Our study aimed to investigate the role of 2 ERCC5 promoter SNPs (rs2094258 and rs751402) in the development of gastric cancer in the Chinese population. The present hospital-based case-control study consisted of 155 patients with gastric cancer and 246 healthy controls recruited between March 2012 and December 2014. Genotyping for the rs2094258 and rs751402 polymorphic sites was carried out using polymerase chain reaction-restriction fragment length polymorphism. Statistical analyses were conducted using the SPASS version 16...
August 26, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27670766/il17ra-gene-variants-and-anti-tnf-response-among-psoriasis-patients
#14
A Batalla, E Coto, J Gómez, N Eirís, D González-Fernández, C Gómez-De Castro, E Daudén, M Llamas-Velasco, R Prieto-Perez, F Abad-Santos, G Carretero, F S García, Y B Godoy, L F Cardo, B Alonso, S Iglesias, P Coto-Segura
Polymorphisms at genes encoding proteins involved in the pathogenesis of psoriasis (Psor) or in the mechanism of action of biological drugs could influence the treatment response. Because the interleukin (IL)-17 family has a central role in the pathogenesis of Psor, we hypothesized that IL17RA variants could influence the response to anti-TNF drugs among Psor patients. To address this issue we performed a cross-sectional study of Psor patients who received the biological treatments for the first time, with a follow-up of at least 6 months...
September 27, 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/27651521/hla-g-and-cd8-regulatory-t-cells-in-the-inflammatory-environment-of-preeclampsia
#15
Priscila Vianna, Andressa Mondadori, Moises E Bauer, Dinara Dornfeld, Jose Artur Chies
During pregnancy the maternal immune system is tolerant to fetal antigens via the engagement of immune regulatory mechanisms. Failure in regulating the maternal immunity to fetal antigens may lead to preeclampsia (PE). We addressed the role of HLAG gene polymorphisms and protein expression as well as regulatory T cells and Th1/Th2/Th17 cytokines in healthy and pathological pregnancies. Blood samples from 26 pregnant women with PE, 25 non-PE and 7 strictly healthy pregnant women were assessed. PBMCs were phenotyped for early activation markers (CD25 and CD69), regulatory T cell markers (CD8+CD28- and CD4+CD25highFoxp3+), ILT-2 (HLA-G receptor) and HLA-G...
September 20, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27595159/polymorphisms-of-il-17-and-icam-1-and-their-expression-in-guillain-barr%C3%A3-syndrome
#16
N K Kharwar, K N Prasad, K Singh, V K Paliwal, D R Modi
PURPOSE: Guillain Barré syndrome (GBS) is an acute inflammatory, autoimmune disorder of peripheral nervous system (PNS). Interleukin-17 (IL-17) and intercellular adhesion molecule-1 (ICAM-1) polymorphisms with higher expression levels have already been studied in many inflammatory and autoimmune diseases. However, the possible role of IL-17 and ICAM-1 polymorphisms in GBS remains unknown. Therefore, the current study investigated IL-17 (His161Arg, Glu126Gly) and ICAM-1 (Gly241Arg) polymorphisms...
September 5, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27591988/il17a-and-il17f-gene-polymorphism-association-with-psoriasis-risk-and-response-to-treatment-in-a-polish-population
#17
Monika Białecka, Roksana Ostasz, Mateusz Kurzawski, Adam Klimowicz, Honorata Fabiańczyk, Piotr Bojko, Violetta Dziedziejko, Krzysztof Safranow, Anna Machoy-Mokrzyńska, Marek Droździk
BACKGROUND: Recent studies have revealed the pivotal role of Th17 cells and interleukin-17 (IL-17) in plaque psoriasis development and treatment outcome. The IL-17 family consists of 6 structurally related cytokines (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F), of which IL-17A and IL-17F mediate similar biological effects. OBJECTIVES: The aim of this study was to evaluate an association between the IL17A (-197G>A; rs2275913) and IL17F (rs763780: T>C; rs11465553: G>A; rs2397084: T>C) polymorphisms with psoriasis susceptibility as well as response to topical and combined topical with narrow-band ultraviolet B (NB-UVB) therapy in a Polish population...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27493142/genetic-determinants-and-postorthodontic-external-apical-root-resorption-in-czech-children
#18
P Borilova Linhartova, P Cernochova, J Kastovsky, Z Vrankova, M Sirotkova, L Izakovicova Holla
OBJECTIVE: Genes, involved in the modulation of inflammatory response and bone remodeling, play a role in the development of postorthodontic external apical root resorption (EARR). The aim of our study was to analyze possible associations between seven single nucleotide polymorphisms (SNPs) in interleukin-17A (IL-17), osteopontin (SPP1), purinoreceptor P2X7 (P2RX7), and tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) genes and EARR in children after orthodontic treatment...
January 2017: Oral Diseases
https://www.readbyqxmd.com/read/27479084/an-asthma-associated-il4r-variant-exacerbates-airway-inflammation-by-promoting-conversion-of-regulatory-t-cells-to-th17-like-cells
#19
Amir Hossein Massoud, Louis-Marie Charbonnier, David Lopez, Matteo Pellegrini, Wanda Phipatanakul, Talal A Chatila
Mechanisms by which regulatory T (Treg) cells fail to control inflammation in asthma remain poorly understood. We show that a severe asthma-associated polymorphism in the gene encoding the interleukin (IL)-4 receptor alpha chain (Il4ra(R576)) promotes conversion of induced Treg (iTreg) cells toward a T helper 17 (TH17) cell fate. This skewing is mediated by the recruitment by IL-4Rα(R576) of the growth-factor-receptor-bound protein 2 (GRB2) adaptor protein, which drives IL-17 expression by activating a pathway that involves extracellular-signal-regulated kinase, IL-6 and the transcription factor STAT3...
September 2016: Nature Medicine
https://www.readbyqxmd.com/read/27464962/identification-of-susceptibility-snps-in-il10-and-il23r-il12rb2-for-beh%C3%A3-et-s-disease-in-han-chinese
#20
Hongsong Yu, Minming Zheng, Lijun Zhang, Hua Li, Yunyun Zhu, Ling Cheng, Lin Li, Bolin Deng, Aize Kijlstra, Peizeng Yang
BACKGROUND: Although previous genome-wide association studies in various cohorts have identified several susceptibility loci underlying Behçet's disease (BD), this has not yet led to a breakthrough in the management of BD. OBJECTIVE: This study aimed to further investigate the association of 26 candidate single nucleotide polymorphisms with previous genome-wide association studies-identified nearly positive P values (5.0 × 10(-8) < P < 1.0 × 10(-5)) in Chinese Han patients with BD...
June 21, 2016: Journal of Allergy and Clinical Immunology
keyword
keyword
80985
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"