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Serrated polyposis

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https://www.readbyqxmd.com/read/28400194/increased-risk-of-colorectal-cancer-in-patients-with-multiple-serrated-polyps-and-their-first-degree-relatives
#1
Cecilia Egoavil, Miriam Juarez, Carla Guarinos, María Rodríguez-Soler, Eva Hernández-Illán, Cristina Alenda, Artemio Payá, Adela Castillejo, Anna Serradesanferm, Luis Bujanda, Fernando Fernández-Bañares, Joaquín Cubiella, Luisa de-Castro, Ana Guerra, Elena Aguirre, Alberto Herreros-de-Tejada, Xavier Bessa, Maite Herráiz, José-Carlos Marín-Gabriel, Judith Balmaña, Virginia Piñol, Miriam Cuatrecasas, Francesc Balaguer, Antoni Castells, José-Luis Soto, Pedro Zapater, Rodrigo Jover
BACKGROUND & AIMS: We investigated whether patients with multiple serrated polyps, but not meeting the World Health Organization criteria for serrated polyposis syndrome, and their relatives have similar risks for colorectal cancer (CRC) as those diagnosed with serrated polyposis. METHODS: We collected data from patients with more than 10 colonic polyps, recruited in 2008-2009 from 24 hospitals in Spain for a study of causes of multiple colonic polyps. We analyzed data from 53 patients who met the criteria for serrated polyposis and 145 patients who did not meet these criteria, but who had more than 10 polyps throughout the colon, of which more than 50% were serrated...
April 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28341823/a-case-with-serrated-polyposis-syndrome-controlled-by-multiple-applications-of-endoscopic-mucosal-resection-and-endoscopic-submucosal-dissection
#2
Daisuke Suzuki, Satohiro Matsumoto, Hirosato Mashima
BACKGROUND Serrated polyposis syndrome (SPS) is characterized by numerous hyperplastic polyps and sessile serrated adenoma/polyp (SSA/P) in the large intestine. SSA/P is known to transform into malignant lesions through the serrated pathway instead of the adenoma-carcinoma sequence. Early diagnosis with lower gastrointestinal endoscopy and early treatment are now considered to be essential. CASE REPORT We had an experience with a case of SPS to which endoscopic treatment was applied in multiple sessions. Endoscopic treatment was performed for 16 lesions in total, and the pathological findings were SSA/P for 15 and adenoma for the other lesion...
March 25, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28253245/reducing-the-polyp-burden-in-serrated-polyposis-by-serial-colonoscopy-the-impact-of-nationally-coordinated-community-surveillance
#3
Susan Parry, Randall W Burt, Aung Ko Win, Ye Kyaw Aung, Sonja Woodall, Julie Arnold, Mark Clendenning, Daniel D Buchanan, Timothy J Price, Christophe Rosty, Joanne P Young
BACKGROUND: Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC) and an evolving management approach. The aims of this study were to assess the polyp burden reduction over time, and the incidence of CRC in serrated polyposis patients undergoing community surveillance. METHODS: This is an observational study based on prospectively collected data. A total of 96 SPS patients with no personal history of CRC were prospectively enrolled in a surveillance program under the guidance of a tertiary center...
March 3, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27783336/attenuated-polyposis-of-the-large-bowel-a-morphologic-and-molecular-approach
#4
Maurizio Ponz de Leon, Monica Pedroni, Luca Roncucci, Federica Domati, Giuseppina Rossi, Giulia Magnani, Annalisa Pezzi, Rossella Fante, Luca Reggiani Bonetti
Attenuated polyposis could be defined as a variant of familial adenomatous polyposis (FAP) in which synchronous polyps of the large bowel range between 10 and 99. We analysed all cases of attenuated polyposis observed over the last 30 years with the objectives: (A) to classify the disease according to different type and proportion of polyps; (B) To ascertain the contribution of APC and MutYH genes; (C) to discover features which could arise the suspicion of mutations; (D) To obtain indications for management and follow-up...
April 2017: Familial Cancer
https://www.readbyqxmd.com/read/27781259/-research-progress-of-serrated-polyposis-syndrome
#5
Shihao Dong, Jingsong Chen
Serrated polyposis syndrome (SPS) is closely associated with the initiation and development of colorectal cancer (CRC), however, there is few research on SPS in China. Serrated polyps can be divided into hyperplastic polyps, sessile serrated polyps and traditional serrated polyps. The diagnosis standard of SPS is as following: (1) There are at least 5 serrated lesions in proximal colon, and diameter of more than 2 lesions is >10 mm; (2) The patient has one serrated polyp with family history of SPS; (3) More than 20 serrated polyps can be found in the entire large bowel...
October 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27741536/reassessment-colonoscopy-to-diagnose-serrated-polyposis-syndrome-in-a-colorectal-cancer-screening-population
#6
Liseth Rivero-Sanchez, Maria Lopez-Ceron, Sabela Carballal, Leticia Moreira, Xavier Bessa, Anna Serradesanferm, Angels Pozo, Josep Maria Augé, Teresa Ocaña, Ariadna Sánchez, María Liz Leoz, Míriam Cuatrecasas, Jaume Grau, Josep Llach, Antoni Castells, Francesc Balaguer, Maria Pellisé
Background and study aims Serrated polyposis syndrome (SPS) is a high risk condition for colorectal cancer (CRC). Surveillance strategies for patients with serrated lesions remain controversial. We aimed to evaluate a diagnostic strategy to detect SPS consistently during reassessment colonoscopy in patients with proximal serrated lesions. Methods This was a retrospective study of all individuals from a fecal immunochemical test (FIT)-based CRC screening program (2010 - 2013) with one or more serrated lesions of ≥ 5 mm proximal to the sigmoid colon on baseline colonoscopy...
January 2017: Endoscopy
https://www.readbyqxmd.com/read/27644675/accuracy-of-fdg-pet-ct-for-detection-of-incidental-pre-malignant-and-malignant-colonic-lesions-correlation-with-colonoscopic-and-histopathologic-findings
#7
Anchisa Kunawudhi, Alexandra K Wong, Tarik K Alkasab, Umar Mahmood
PURPOSE: We evaluated all PET/CTs acquired for patients without a primary diagnosis of colorectal cancer, and compared results for those who had subsequent colonoscopy within 6 months, to assess the accuracy of FDG PET/CT for detection of incidental pre-malignant polyps and malignant colon cancers. MATERIALS AND METHODS: Medical records of 9,545 patients who underwent F-18 FDG PET/CT studies over 3.5 years were retrospectively reviewed. Due to pre-existing diagnosis of colorectal cancer, 818 patients were excluded...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27499922/the-molecular-characteristics-of-colonic-neoplasms-in-serrated-polyposis-a-systematic-review-and-meta-analysis
#8
REVIEW
Emily Y He, Lucy Wyld, Mathew A Sloane, Karen Canfell, Robyn L Ward
Serrated polyposis is a rare disorder characterised by the presence of multiple serrated polyps in the large intestine, and an increased personal and familial risk of colorectal cancer. Knowledge of the molecular characteristics of colonic lesions which develop in this syndrome is fragmented, making it difficult to understand the underlying genetic basis of this condition. We conducted a systematic review and meta-analysis of all studies which evaluated the molecular characteristics of colorectal neoplasms found in individuals with serrated polyposis...
July 2016: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/27430658/serrated-polyposis-associated-with-a-family-history-of-colorectal-cancer-and-or-polyps-the-preferential-location-of-polyps-in-the-colon-and-rectum-defines-two-molecular-entities
#9
Patrícia Silva, Cristina Albuquerque, Pedro Lage, Vanessa Fontes, Ricardo Fonseca, Inês Vitoriano, Bruno Filipe, Paula Rodrigues, Susana Moita, Sara Ferreira, Rita Sousa, Isabel Claro, Carlos Nobre Leitão, Paula Chaves, António Dias Pereira
Serrated polyposis (SPP) is characterized by the development of multiple serrated polyps and an increased predisposition to colorectal cancer (CRC). In the present study, we aimed to characterize, at a clinical and molecular level, a cohort of SPP patients with or without a family history of SPP and/or polyps/CRC (SPP-FHP/CRC). Sixty-two lesions from 12 patients with SPP-FHP/CRC and 6 patients with sporadic SPP were included. The patients with SPP-FHP/CRC presented with an older mean age at diagnosis (p=0...
September 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27345133/high-yield-of-synchronous-lesions-in-referred-patients-with-large-lateral-spreading-colorectal-tumors
#10
Benjamin L Bick, Prasanna L Ponugoti, Douglas K Rex
BACKGROUND AND AIMS: There are few data on the prevalence of synchronous colorectal lesions in patients who have large lateral spreading tumors (LLSTs). We sought to describe the rate of synchronous lesions found in patients who underwent endoscopic resection of large sessile adenomas and serrated lesions. METHODS: This is a retrospective assessment of a prospectively created database of 728 consecutive patients with resected LLSTs who underwent complete clearing of the colon during 2 colonoscopies by a single expert endoscopist...
January 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27329244/rnf43-germline-and-somatic-mutation-in-serrated-neoplasia-pathway-and-its-association-with-braf-mutation
#11
Helen H N Yan, Jeffrey C W Lai, Siu Lun Ho, Wai Keung Leung, Wai Lun Law, Janet F Y Lee, Anthony K W Chan, Wai Yin Tsui, Annie S Y Chan, Bernard C H Lee, Sarah S K Yue, Alice H Y Man, Hans Clevers, Siu Tsan Yuen, Suet Yi Leung
OBJECTIVE: Serrated polyps (hyperplastic polyps, sessile or traditional serrated adenomas), which can arise in a sporadic or polyposis setting, predispose to colorectal cancer (CRC), especially those with microsatellite instability (MSI) due to MLH1 promoter methylation (MLH1(me+)). We investigate genetic alterations in the serrated polyposis pathway. DESIGN: We used a combination of exome sequencing and target gene Sanger sequencing to study serrated polyposis families, sporadic serrated polyps and CRCs, with validation by analysis of The Cancer Genome Atlas (TCGA) cohort, followed by organoid-based functional studies...
June 21, 2016: Gut
https://www.readbyqxmd.com/read/27310819/identification-of-familial-colorectal-cancer-and-hereditary-colorectal-cancer-syndromes-through-the-dutch-population-screening-program-results-ofa-pilot-study
#12
Sanne J H van Erp, Laura W Leicher, Simone D Hennink, Zeinab Ghorbanoghli, Simone A C Breg, Hans Morreau, Maartje Nielsen, James C H Hardwick, Jan A Roukema, Alexandra M J Langers, Walter H de Vos Tot Nederveen Cappel, Hans F A Vasen
OBJECTIVES: In 2014, a population-screening program using immuno-faecal occult blood testing (I-FOBT) has started in the Netherlands. The aims of this study were to evaluate the proportion of individuals in the Dutch screening program with a positive I-FOBT that fulfill the criteria for familial colorectal cancer (FCC) and to evaluate the proportion of participants that needs genetic counseling or colonoscopic surveillance. MATERIAL AND METHODS: This retrospective observational study was performed in two large hospitals...
October 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27145315/the-studded-rectum-phenotypic-evidence-of-myh-associated-polyposis
#13
James Church, Sara Kravochuck
BACKGROUND: MYH-associated polyposis is a recessively inherited syndrome of colorectal cancer predisposition attributed to biallelic germline mutations in the base excision repair gene MYH. Clinically it overlaps with attenuated familial adenomatous polyposis, sporadic oligopolyposis, serrated polyposis, familial colorectal cancer type X, and Lynch syndrome. There is no specific phenotypic feature of MYH-associated polyposis. We have noticed that a proportion of patients with MYH-associated polyposis presenting for yearly colonoscopy surveillance have rectums that are studded with small hyperplastic polyps...
June 2016: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27087961/type-1-serrated-polyposis-represents-a-predominantly-female-disease-with-a-high-prevalence-of-dysplastic-serrated-adenomas-without-germline-mutation-in-mutyh-apc-and-pten-genes
#14
Marco Petronio, Stephane Pinson, Thomas Walter, Marie-Odile Joly, Valerie Hervieu, Julien Forestier, Jean-Christophe Saurin
AIM: The aim of this article is to clarify the epidemiologic, clinical, endoscopic, biological and genetic characteristics of type 1 serrated polyposis patients. PATIENTS AND METHODS: Consecutive patients responding to the WHO definition of type 1 serrated polyposis in one reference center for polyposis patients accepted genetic counseling. Detailed data on previous endoscopies, histology, and life habits were recorded, after informed consent, germline analysis of MUTYH, APC, and PTEN germline mutations...
April 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27026680/gene-signature-in-sessile-serrated-polyps-identifies-colon-cancer-subtype
#15
Priyanka Kanth, Mary P Bronner, Kenneth M Boucher, Randall W Burt, Deborah W Neklason, Curt H Hagedorn, Don A Delker
Sessile serrated colon adenoma/polyps (SSA/P) are found during routine screening colonoscopy and may account for 20% to 30% of colon cancers. However, differentiating SSA/Ps from hyperplastic polyps (HP) with little risk of cancer is challenging and complementary molecular markers are needed. In addition, the molecular mechanisms of colon cancer development from SSA/Ps are poorly understood. RNA sequencing (RNA-Seq) was performed on 21 SSA/Ps, 10 HPs, 10 adenomas, 21 uninvolved colon, and 20 control colon specimens...
June 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27020206/serrated-lesions-of-the-appendix-in-serrated-polyposis-patients
#16
Mark Bettington, Ian S Brown, Christophe Rosty
Patients with serrated polyposis develop multiple serrated polyps throughout the large bowel: hyperplastic polyps (HP), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). The frequency and the characteristics of serrated lesions of the appendix have not been reported in serrated polyposis patients. We conducted a retrospective study of 34 serrated polyposis patients who underwent a total or right hemicolectomy for adenocarcinoma or polyp burden. An appendiceal serrated lesion was identified in 23 (68%): 13 SSAs, three SSAs with dysplasia, four HPs and three TSAs...
January 2016: Pathology
https://www.readbyqxmd.com/read/26984550/carcinoma-of-the-colon-and-rectum-with-deregulation-of-insulin-like-growth-factor-2-signaling-clinical-and-molecular-implications
#17
Djeda Belharazem, Julia Magdeburg, Ann-Kristin Berton, Li Beissbarth, Christian Sauer, Carsten Sticht, Alexander Marx, Ralf Hofheinz, Stefan Post, Peter Kienle, Philipp Ströbel
BACKGROUND: Loss of imprinting (LOI) of the insulin-like growth factor 2 (IGF2) is an early event in the development of colorectal cancer (CRC). Whether LOI of IGF2 denotes a molecular or clinical cancer subgroup is currently unknown. METHODS: Tumor biopsies and paired normal mucosa from 399 patients with extensive clinical annotations were analyzed for LOI and IGF2 expression. LOI status in 140 informative cases was correlated with clinicopathologic parameters and outcome...
October 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/26911398/detection-rate-of-serrated-polyps-and-serrated-polyposis-syndrome-in-colorectal-cancer-screening-cohorts-a-european-overview
#18
J E G IJspeert, R Bevan, C Senore, M F Kaminski, E J Kuipers, A Mroz, X Bessa, P Cassoni, C Hassan, A Repici, F Balaguer, C J Rees, E Dekker
OBJECTIVE: The role of serrated polyps (SPs) as colorectal cancer precursor is increasingly recognised. However, the true prevalence SPs is largely unknown. We aimed to evaluate the detection rate of SPs subtypes as well as serrated polyposis syndrome (SPS) among European screening cohorts. METHODS: Prospectively collected screening cohorts of ≥1000 individuals were eligible for inclusion. Colonoscopies performed before 2009 and/or in individuals aged below 50 were excluded...
February 24, 2016: Gut
https://www.readbyqxmd.com/read/26907826/serrated-polyposis-syndrome-risk-stratification-or-reduction
#19
C Hassan, A Repici, D K Rex
No abstract text is available yet for this article.
July 2016: Gut
https://www.readbyqxmd.com/read/26890540/serrated-polyposis-syndrome-a-silent-killer-when-undetected
#20
Joep E G IJspeert, Barbara A J Bastiaansen, Evelien Dekker
No abstract text is available yet for this article.
2016: Endoscopy
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