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https://www.readbyqxmd.com/read/28514279/impact-of-alemtuzumab-on-hiv-persistence-in-an-hiv-infected-individual-on-antiretroviral-therapy-with-sezary-syndrome
#1
Thomas Aagaard Rasmussen, James McMahon, J Judy Chang, Jori Symons, Michael Roche, Ashanti Dantanarayana, Afam Okoye, Bonnie Hiener, Sarah Palmer, Wen Shi Lee, Stephen Kent, Carrie Van Der Weyden, H Miles Prince, Paul U Cameron, Sharon R Lewin
OBJECTIVE: To study the effects of alemtuzumab on HIV persistence in an HIV-infected individual on antiretroviral therapy (ART) with Sezary syndrome, a rare malignancy of CD4+ T-cells DESIGN:: Case report. METHODS: Blood was collected 30 and 18 months prior to presentation with Sezary syndrome, at the time of presentation and during alemtuzumab. T-cell subsets in malignant (CD7-CD26-TCR-VBeta2+) and non-malignant cells were quantified by flow cytometry. HIV-DNA in total CD4+ T-cells, in sorted malignant and non-malignant CD4+ T-cells was quantified by PCR and clonal expansion of HIV-DNA assessed by full-length next-generation sequencing...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28492397/post-treatment-control-in-an-adult-with-perinatally-acquired-hiv-following-cessation-of-antiretroviral-therapy
#2
James H McMahon, Judy Chang, Surekha Tennakoon, Ashanti Dantanarayana, Ajantha Solomon, Catherine Cherry, Richard Doherty, Paul Cameron, Sharon R Lewin
No abstract text is available yet for this article.
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28449387/sustaining-nurse-led-task-shifting-strategies-for-hypertension-control-a-concept-mapping-study-to-inform-evidence-based-practice
#3
Sarah Blackstone, Juliet Iwelunmor, Jacob Plange-Rhule, Joyce Gyamfi, Nana Kofi Quakyi, Micheal Ntim, Gbenga Ogedegbe
BACKGROUND: The use of task-shifting is an increasingly widespread delivery approach for health interventions targeting prevention, treatment, and control of hypertension in adults living in sub-Saharan Africa (SSA). Addressing a gap in the literature, this research examined the sustainability of an ongoing task-shifting strategy for hypertension (TASSH) from the perspectives of community health nurses (CHNs) implementing the program. METHODS: We used concept-mapping, a mixed-methods participatory approach to understand CHNs' perceptions of barriers and enablers to sustaining a task-shifting program...
April 27, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28437439/landscape-and-environmental-influences-on-mycobacterium-ulcerans-distribution-among-aquatic-sites-in-ghana
#4
Shannon M Pileggi, Heather Jordan, Julie A Clennon, Ellen Whitney, M Eric Benbow, Richard Merritt, Mollie McIntosh, Ryan Kimbirauskas, Pamela Small, Daniel Boakye, Charles Quaye, Jiaguo Qi, Lindsay Campbell, Jenni Gronseth, Edwin Ampadu, William Opare, Lance A Waller
Buruli ulcer, caused by Mycobacterium ulcerans, is highly endemic in West Africa. While the mode of transmission is unknown, many studies associate Buruli ulcer with different types of water exposure. We present results from the largest study to date to test for M. ulcerans in aquatic sites and identify environmental attributes associated with its presence. Environmental samples from 98 aquatic sites in the Greater Accra, Ashanti, and Volta regions of Ghana were tested for the presence of M. ulcerans DNA by polymerase chain reaction...
2017: PloS One
https://www.readbyqxmd.com/read/28430032/sociocultural-hegemony-gendered-identity-and-use-of-traditional-and-complementary-medicine-in-ghana
#5
Razak Mohammed Gyasi, Daniel Buor, Samuel Adu-Gyamfi, Prince Osei-Wusu Adjei, Padmore Adusei Amoah
This study investigated gender differences in the use of traditional and complementary medicine (TCM) in Ghana. Using an interviewer-administered questionnaire, we collected data from March to June 2013 from 324 randomly sampled adults in the Ashanti region. The prevalence of TCM use in the prior 12 months was 86 percent. Females constituted the majority (61 percent) of TCM users. Female TCM users were more likely than male users to have had only a basic education, been traders (p ˂ .0001), and have health insurance (p ˂ ...
April 21, 2017: Women & Health
https://www.readbyqxmd.com/read/28301423/no-adverse-safety-or-virological-changes-2-years-following-vorinostat-in-hiv-infected-individuals-on-antiretroviral-therapy
#6
Talia M Mota, Thomas A Rasmussen, Ajantha Rhodes, Surekha Tennakoon, Ashanti Dantanarayana, Fiona Wightman, Michelle Hagenauer, Janine Roney, Tim Spelman, Damian F J Purcell, James McMahon, Jennifer F Hoy, H Miles Prince, Julian H Elliott, Sharon R Lewin
OBJECTIVE: To determine the long-term effects of vorinostat on safety and virological parameters in HIV-infected individuals on suppressive antiretroviral therapy (ART). DESIGN: Prospective longitudinal observational extended follow-up of 20 HIV-infected individuals on ART previously enrolled in a clinical trial of daily vorinostat 400 mg for 14 days. Extended follow-up included visits at 6, 12, 18 and 24 months postenrolment in the initial clinical trial. METHODS: Cell-associated unspliced HIV RNA, total HIV DNA and plasma HIV RNA were quantified by PCR, and CD4 and CD8 T cells quantified by flow cytometry...
May 15, 2017: AIDS
https://www.readbyqxmd.com/read/28219344/origin-and-phylogenetic-status-of-the-local-ashanti-dwarf-pig-adp-of-ghana-based-on-genetic-analysis
#7
Richard Osei-Amponsah, Benjamin M Skinner, Dennis O Adjei, Julien Bauer, Greger Larson, Nabeel A Affara, Carole A Sargent
BACKGROUND: The Ashanti Dwarf Pig (ADP) of Ghana is an endangered pig breed with hardy and disease resistant traits. Characterisation of animal genetic resources provides relevant data for their conservation and sustainable use for food security and economic development. We investigated the origin and phylogenetic status of the local ADP of Ghana and their crosses with modern commercial breeds based on mtDNA, MC1R, Y-chromosome sequence polymorphisms, and genome-wide SNP genotyping. RESULTS: The study involved 164 local pigs sampled from the three agro-ecological zones of Ghana...
February 20, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28115672/rickettsia-felis-infection-in-febrile-children-ghana
#8
Peter Sothmann, Christian Keller, Ralf Krumkamp, Benno Kreuels, Cassandra Aldrich, Nimako Sarpong, Stefanie Steierberg, Doris Winter, Kennedy Gyau Boahen, Ellis Owusu-Dabo, Jürgen May, Daniel Eibach
AbstractRickettsial infections are an underrecognized cause of febrile illness in sub-Saharan Africa. To evaluate the epidemiology and clinical features of rickettsial disease in pediatric patients in Ghana, we screened blood samples from febrile children aged less than 15 years presenting to an outpatient department in Ghana's Ashanti Region for the presence of rickettsial DNA. We detected Rickettsia felis in 7/470 (1.5%) blood samples, using two independent real-time polymerase chain reactions. No other Rickettsia species were found...
April 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28107412/nasal-carriage-of-staphylococcus-aureus-among-children-in-the-ashanti-region-of-ghana
#9
Daniel Eibach, Michael Nagel, Benedikt Hogan, Clinton Azuure, Ralf Krumkamp, Denise Dekker, Mike Gajdiss, Melanie Brunke, Nimako Sarpong, Ellis Owusu-Dabo, Jürgen May
BACKGROUND: Nasal carriage with Staphylococcus aureus is a common risk factor for invasive infections, indicating the necessity to monitor prevalent strains, particularly in the vulnerable paediatric population. This surveillance study aims to identify carriage rates, subtypes, antimicrobial susceptibilities and virulence markers of nasal S. aureus isolates collected from children living in the Ashanti region of Ghana. METHODS: Nasal swabs were obtained from children < 15 years of age on admission to the Agogo Presbyterian Hospital between April 2014 and January 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28104671/lack-of-association-of-cd55-receptor-genetic-variants-and-severe-malaria-in-ghanaian-children
#10
Kathrin Schuldt, Christa Ehmen, Juergen Sievertsen, Jennifer Evans, Juergen May, Daniel Ansong, Birgit Muntau, Gerd Ruge, Christian Timmann, Tsiri Agbenyega, Rolf D Horstmann, Thorsten Thye
In a recent report, the cellular receptor CD55 was identified as a molecule essential for the invasion of human erythrocytes by Plasmodium falciparum, the causal agent of the most severe form of malaria. As this invasion process represents a critical step during infection with the parasite, it was hypothesized that genetic variants in the gene could affect severe malaria (SM) susceptibility. We performed high-resolution variant discovery of rare and common genetic variants in the human CD55 gene. Association testing of these variants in over 1700 SM cases and unaffected control individuals from the malaria-endemic Ashanti Region in Ghana, West Africa, were performed on the basis of single variants, combined rare variant analyses, and reconstructed haplotypes...
March 10, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28088259/integration-for-coexistence-implementation-of-intercultural-health-care-policy-in-ghana-from-the-perspective-of-service-users-and-providers
#11
Razak Mohammed Gyasi, Adjoa Afriyie Poku, Simon Boateng, Padmore Adusei Amoah, Alhassan Abdul Mumin, Jacob Obodai, Williams Agyemang-Duah
OBJECTIVE: In spite of the World Health Organization's recommendations over the past decades, Ghana features pluralistic rather than truly integrated medical system. Policies about the integration of complementary medicine into the national health care delivery system need to account for individual-level involvement and cultural acceptability of care rendered by health care providers. Studies in Ghana, however, have glossed over the standpoint of the persons of the illness episode about the intercultural health care policy framework...
January 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28061905/epidemiology-of-mansonella-perstans-in-the-middle-belt-of-ghana
#12
Linda Batsa Debrah, Norman Nausch, Vera Serwaa Opoku, Wellington Owusu, Yusif Mubarik, Daniel Antwi Berko, Samuel Wanji, Laura E Layland, Achim Hoerauf, Marc Jacobsen, Alexander Yaw Debrah, Richard O Phillips
BACKGROUND: Mansonellosis was first reported in Ghana by Awadzi in the 1990s. Co-infections of Mansonella perstans have also been reported in a small cohort of patients with Buruli ulcer and their contacts. However, no study has assessed the exact prevalence of the disease in a larger study population. This study therefore aimed to find out the prevalence of M. perstans infection in some districts in Ghana and to determine the diversity of Culicoides that could be potential vectors for transmission...
January 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/27973260/household-cost-of-injuries-in-children-under-five-years-in-the-ejisu-juabeng-municipality-of-the-ashanti-region-ghana-a-cross-sectional-study
#13
J Amissah
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27938360/overweight-and-obesity-epidemic-in-ghana-a-systematic-review-and-meta-analysis
#14
Richard Ofori-Asenso, Akosua Adom Agyeman, Amos Laar, Daniel Boateng
BACKGROUND: In many low and middle income countries (LMICs), the distribution of adulthood nutritional imbalance is shifting from a predominance of undernutrition to overnutrition. This complex problem poses a huge challenge to governments, non-state actors, and individuals desirous of addressing the problem of malnutrition in LMICs. The objective of this study was to systematically review the literature towards providing an estimate of the prevalence of overweight and obesity among adult Ghanaians...
December 9, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27927238/insecticide-resistance-in-malaria-vectors-in-kumasi-ghana
#15
Sandra Baffour-Awuah, Augustina A Annan, Oumou Maiga-Ascofare, Soma Diloma Dieudonné, Priscilla Adjei-Kusi, Ellis Owusu-Dabo, Kwasi Obiri-Danso
BACKGROUND: There have been recent reports of surge in resistance to insecticides in pocketed areas in Ghana necessitating the need for information about local vector populations and their resistance to the insecticides approved by the World Health Organization (WHO). We therefore studied a population of malaria vectors from Kumasi in the Ashanti Region of Ghana and their resistance to currently used insecticides. We conducted susceptibility tests to the four major classes of insecticides by collecting larvae of anopheline mosquitoes from several communities in the region...
December 7, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27899074/antibiotic-resistance-and-clonal-diversity-of-invasive-staphylococcus-aureus-in-the-rural-ashanti-region-ghana
#16
Denise Dekker, Manuel Wolters, Eva Mertens, Kennedy Gyau Boahen, Ralf Krumkamp, Daniel Eibach, Norbert G Schwarz, Yaw Adu-Sarkodie, Holger Rohde, Martin Christner, Florian Marks, Nimako Sarpong, Jürgen May
BACKGROUND: Staphylococcus aureus is among the most common pathogens isolated from blood cultures in Ghana; yet the epidemiology of blood infections in rural settings is poorly described. This study aims to investigate antimicrobial susceptibility and clonal diversity of S. aureus causing bloodstream infections in two hospitals in the Ashanti Region, Ghana. METHODS: Blood cultures were performed for all febrile patients (≥37.5 °C) on hospital admission. Antibiotic susceptibility testing for S...
November 29, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27807453/comparative-analysis-of-households-solid-waste-management-in-rural-and-urban-ghana
#17
Simon Boateng, Prince Amoako, Divine Odame Appiah, Adjoa Afriyie Poku, Emmanuel Kofi Garsonu
The comparative analysis of solid waste management between rural and urban Ghana is largely lacking. This study investigated the solid waste situation and the organisation of solid waste management in both urban and rural settings from the perspective of households. The study employed cross-sectional survey covering both rural and urban districts in the Ashanti and Greater Accra Regions of Ghana. The study systematically sampled houses from which 400 households and respondents were randomly selected. Pearson's Chi square test was used to compare demographic and socioeconomic variables in rural and urban areas...
2016: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/27784594/scorecards-and-social-accountability-for-improved-maternal-and-newborn-health-services-a-pilot-in-the-ashanti-and-volta-regions-of-ghana
#18
Carolyn Blake, Nii Ankonu Annorbah-Sarpei, Claire Bailey, Yakubu Ismaila, Sylvia Deganus, Samuel Bosomprah, Francesco Galli, Sarah Clark
BACKGROUND: With the limited availability of quality emergency obstetric and newborn care (EmONC) in Ghana, and a lack of dialogue on the issue at district level, the Evidence for Action (E4A) program (2011-2015) initiated a pilot intervention using a social accountability approach in two regions of Ghana. OBJECTIVE: Using scorecards to assess and improve maternal and newborn health services, the intervention study evaluated the effectiveness of engaging multiple, health and non-health sector stakeholders at district level to improve the enabling environment for quality EmONC...
December 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27641949/socio-demographic-factors-associated-with-dietary-behaviour-among-young-ghanaians-aged-15-34-years
#19
Acheampong Yaw Amoateng, Phidelia Theresa Doegah, Christopher Udomboso
This study used data from the 2008 Ghana Demographic and Health Survey to investigate the association between selected socio-demographic factors and dietary behaviour as measured by fruit and vegetable consumption among a sample of 6139 young people aged 15-34 years in Ghana. Overall, fruit and vegetable consumption was low in young people, but females were likely to consume more fruit and vegetables than their male counterparts. Respondents from the Mande ethnic group, those who resided in rural areas and those living in the Brong/Ahafo, Ashanti and the Eastern regions consumed more fruit and vegetables than those from other regions...
September 19, 2016: Journal of Biosocial Science
https://www.readbyqxmd.com/read/27599835/economic-burden-of-malaria-on-businesses-in-ghana-a-case-for-private-sector-investment-in-malaria-control
#20
Justice Nonvignon, Genevieve Cecilia Aryeetey, Keziah L Malm, Samuel Agyei Agyemang, Vivian N A Aubyn, Nana Yaw Peprah, Constance N Bart-Plange, Moses Aikins
BACKGROUND: Despite the significant gains made globally in reducing the burden of malaria, the disease remains a major public health challenge, especially in sub-Saharan Africa (SSA) including Ghana. There is a significant gap in financing malaria control globally. The private sector could become a significant source of financing malaria control. To get the private sector to appreciate the need to invest in malaria control, it is important to provide evidence of the economic burden of malaria on businesses...
2016: Malaria Journal
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