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https://www.readbyqxmd.com/read/29764405/urinary-iodine-concentration-and-thyroid-volume-of-pregnant-women-attending-antenatal-care-in-two-selected-hospitals-in-ashanti-region-ghana-a-comparative-cross-sectional-study
#1
Daniel Gyamfi, Yaw Amo Wiafe, Kwabena Owusu Danquah, Ernest Adankwah, Gertrude Akua Amissah, Angela Odame
BACKGROUND: Iodine deficiency is a major public health problem affecting people worldwide, particularly pregnant women. Iodine requirements increase substantially during pregnancy making pregnant women vulnerable to iodine deficiency and its disorders such as abortions, stillbirths and pregnancy goitre as well as congenital abnormalities, cretinism and mental retardation in their children. The primary aim of this study was to evaluate the prevalence of iodine deficiency and goitre among pregnant women attending antenatal sessions at two selected hospitals in Ashanti region, Ghana...
May 15, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29757256/social-networks-and-health-understanding-the-nuances-of-healthcare-access-between-urban-and-rural-populations
#2
Padmore Adusei Amoah, Joseph Edusei, David Amuzu
Communities and individuals in many sub-Saharan African countries often face limited access to healthcare. Hence, many rely on social networks to enhance their chances for adequate health care. While this knowledge is well-established, little is known about the nuances of how different population groups activate these networks to improve access to healthcare. This paper examines how rural and urban dwellers in the Ashanti Region in Ghana distinctively and systematically activate their social networks to enhance access to healthcare...
May 13, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29746296/pd-1-contributes-to-the-establishment-and-maintenance-of-hiv-1-latency
#3
Vanessa A Evans, Renée M Van Der Sluis, Ajantha Solomon, Ashanti Dantanarayana, Catriona McNeil, Roger Garsia, Sarah Palmer, Rémi Fromentin, Nicolas Chomont, Rafick-Pierre Sékaly, Paul U Cameron, Sharon R Lewin
OBJECTIVE: In HIV-infected individuals on antiretroviral therapy (ART), latent HIV is enriched in CD4 T-cells expressing immune checkpoint molecules (ICs), in particular programmed cell death-1 (PD-1). We therefore assessed the effect of blocking PD-1 on latency, both in vitro and in vivo. METHODS: HIV latency was established in vitro following co-culture of resting CD4 T-cells with myeloid dendritic cells. Expression of PD-1 was quantified by flow cytometry, and latency assessed in sorted PD-1 and PD-1 non-proliferating CD4 memory T-cells...
May 9, 2018: AIDS
https://www.readbyqxmd.com/read/29727351/comparison-of-different-surgical-approaches-for-stage-ib1-cervical-cancer-patients-a-multi-institution-study-and-a-review-of-the-literature
#4
Giacomo Corrado, Enrico Vizza, Francesco Legge, Luigi Pedone Anchora, Isabella Sperduti, Anna Fagotti, Emanuela Mancini, Valerio Gallotta, Ashanti Zampa, Benito Chiofalo, Giovanni Scambia
OBJECTIVE: The aim of this retrospective study was to assess the surgical and oncological outcome of 3 different surgical approaches (laparotomy, laparoscopy, and robotic surgery) in the treatment of early-stage cervical cancer International Federation of Gynecology and Obstetrics (FIGO) stage IB1. METHODS: All patients with a histologically confirmed diagnosis of early-stage cervical cancer, FIGO stage IB1, who underwent abdominal radical hysterectomy (ARH), laparoscopic radical hysterectomy, or robotic radical hysterectomy with or without pelvic and aortic lymphadenectomy were included in the study...
April 30, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29688330/novel-thioglycoside-analogs-of-%C3%AE-galactosylceramide-stimulate-cytotoxicity-and-preferential-th1-cytokine-production-by-human-invariant-natural-killer-t-cells
#5
Ashanty M Melo, Lei Zhang, Éilis F Dockry, Andreea Petrasca, Yasmeen G Ghnewa, Eamon P Breen, Maria E Morrissey, Ciara O'Reilly, Robyn Bruen, Andrew O'Meara, Joanne Lysaght, Xiangming Zhu, Derek G Doherty
Invariant natural killer T (iNKT) cells recognize glycolipid antigens bound to CD1d molecules on antigen-presenting cells. Therapeutic activation of iNKT cells with the xenogeneic glycolipid α-galactosylceramide (α-GalCer) can prevent and reverse tumor growth in murine models, but clinical trials using α-GalCer-stimulated human iNKT cells have shown limited efficacy. We synthesized a series of thioglycoside analogs of α-GalCer with different substituents to the galactose residue and found that two of these compounds, XZ7 and XZ11, bound to CD1d-transfected HeLa cells and activated lines of expanded human iNKT cells...
April 6, 2018: Glycobiology
https://www.readbyqxmd.com/read/29643011/the-effect-of-antiretroviral-intensification-with-dolutegravir-on-residual-virus-replication-in-hiv-infected-individuals-a-randomised-placebo-controlled-double-blind-trial
#6
Thomas A Rasmussen, James H McMahon, J Judy Chang, Jennifer Audsley, Ajantha Rhodes, Surekha Tennakoon, Ashanti Dantanarayana, Tim Spelman, Tina Schmidt, Stephen J Kent, Vincent Morcilla, Sarah Palmer, Julian H Elliott, Sharon R Lewin
BACKGROUND: Whether ongoing virus replication occurs in HIV-infected individuals on antiretroviral therapy (ART) is unclear; therefore, whether residual virus replication is a barrier to achieving a cure for HIV is also unknown. We aimed to establish whether ART intensification with dolutegravir would reveal or affect residual virus replication in HIV-infected individuals on suppressive treatment. METHODS: In this randomised, placebo-controlled, double-blind trial, we enrolled HIV-infected adults (aged 18 years and older) receiving combination ART (at least three agents) for at least 3 years from the Alfred Hospital and Melbourne Sexual Health Centre, Melbourne, VIC, Australia...
May 2018: Lancet HIV
https://www.readbyqxmd.com/read/29596950/one-year-effects-of-a-group-based-lifestyle-intervention-in-adults-with-type-2-diabetes-a-randomized-encouragement-trial
#7
David T Liss, Emily A Finch, Andrew Cooper, Avani Sheth, Ashantí D Tejuosho, Nicola Lancki, Ronald T Ackermann
AIMS: To estimate the real-world effects of offering a group-based lifestyle intervention (GLI) to adults with diabetes. METHODS: This randomized encouragement trial included adult primary care patients in metropolitan Chicago with type 2 diabetes and body mass index ≥24 kg/m2. Participants were randomized to standard care (brief dietary and lifestyle counseling) or standard care plus being encouraged, but not required, to participate in a free-of-charge GLI offered by the YMCA...
March 26, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29541448/multidrug-resistant-gram-negative-bacterial-infections-in-a-teaching-hospital-in-ghana
#8
Nicholas Agyepong, Usha Govinden, Alex Owusu-Ofori, Sabiha Yusuf Essack
Background: Multidrug-resistant Gram-negative bacteria have emerged as major clinical and therapeutic dilemma in hospitals in Ghana.To describe the prevalence and profile of infections attributable to multidrug-resistant Gram-negative bacteria among patients at the Komfo Anokye Teaching Hospital in the Ashanti region of Ghana. Methods: Bacterial cultures were randomly selected from the microbiology laboratory from February to August, 2015. Bacterial identification and minimum inhibitory concentrations were conducted using standard microbiological techniques and the Vitek-2 automated system...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29520728/completing-the-maternal-care-team-ob-gyn-expertise-at-rural-district-hospitals-in-ghana-a-qualitative-study
#9
Eva M Luo, Henry S Opare-Ado, Joseph Adomako, Kwabena A Danso, Talya Peltzman, Frank W J Anderson
Introduction To provide a qualitative perspective on the changes that occurred after newly placed OB/GYNs began working at district hospitals in Ashanti, Ghana. Methods Structured interviews of healthcare professionals were conducted at eight district hospitals located throughout the Ashanti district of Ghana, four with and four without a full-time OB/GYN on staff. Individuals interviewed include: medical superintendents, medical officers, district hospital administrators, OB/GYNs (where applicable), and nurse-midwives...
March 8, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29514594/perception-of-quality-health-care-delivery-under-capitation-payment-a-cross-sectional-survey-of-health-insurance-subscribers-and-providers-in-ghana
#10
Francis-Xavier Andoh-Adjei, Eric Nsiah-Boateng, Felix Ankomah Asante, Ernst Spaan, Koos van der Velden
BACKGROUND: Ghana introduced capitation payment method in 2012 but was faced with resistance for its perceived poor quality of care. This paper assesses National Health Insurance Scheme subscribers and care providers' perception of quality of care under the capitation payment method. METHODS: This is a cross-sectional survey of subscribers and care providers perception of quality of care in three administrative regions of Ghana using a 5-point Likert scale for the assessment based on a set of quality of care measures...
March 7, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29506518/educational-status-and-beliefs-regarding-non-communicable-diseases-among-children-in-ghana
#11
Delali M Badasu, Aaron A Abuosi, Francis A Adzei, John K Anarfi, Alfred E Yawson, Deborah A Atobrah
BACKGROUND: Increasing prevalence of non-communicable diseases (NCDs) has been observed in Ghana as in other developing countries. Past research focused on NCDs among adults. Recent researches, however, provide evidence on NCDs among children in many countries, including Ghana. Beliefs about the cause of NCDs among children may be determined by the socioeconomic status of parents and care givers. This paper examines the relationship between educational status of parents and/or care givers of children with NCDs on admission and their beliefs regarding NCDs among children...
March 5, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29463277/correction-to-serum-dna-integrity-index-as-a-potential-molecular-biomarker-in-endometrial-cancer
#12
Enrico Vizza, Giacomo Corrado, Martina De Angeli, Mariantonia Carosi, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Lodovico Patrizi, Ashanti Zampa, Giulia Piaggio, Lucia Cicchillitti
In the publication of this article [1], there is an error in the first sentence of the Acknowledgements section.
February 20, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29447613/-who-ll-do-all-these-if-i-m-not-around-bonding-social-capital-and-health-and-well-being-of-inpatients
#13
Padmore Adusei Amoah, Adwoa Owusuaa Koduah, Razak Mohammed Gyasi
PURPOSE: Although social capital influences health-related decisions and behavioural patterns in many developing countries, minimal attention has been paid to the nuances of its effect on healthcare. This paper examines how bonding social capital affects healthcare delivery for inpatients in Ghana. METHODS: Semi-structured in-depth interviews were used and thematic analysis method employed to analyse the data. Interviews were conducted with health professionals and relatives and close friends of inpatients in three public health facilities in Ashanti region...
December 2018: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/29438730/human-v%C3%AE-3-%C3%AE-%C3%AE-t-cells-induce-maturation-and-igm-secretion-by-b-cells
#14
Andreea Petrasca, Ashanty M Melo, Eamon P Breen, Derek G Doherty
This study tested the hypothesis that the Vδ3 subset of human γδ T cells, like their Vδ2 counterparts, can influence differentiation, antibody secretion and cytokine production by B cells. Vδ3 T cells constitute a minor subset of peripheral blood lymphocytes but are enriched in the liver and gut and are expanded in patients with cytomegalovirus activation and B cell chronic lymphocytic leukemia. They have been reported to include MHC class I and CD1d restricted cells. Like Vδ2 T cells, they are capable of maturing dendritic cells into cytokine-producing antigen presenting cells, making them potential targets for dendritic cell-based immunotherapies...
April 2018: Immunology Letters
https://www.readbyqxmd.com/read/29383155/circulating-cell-free-dna-content-as-blood-based-biomarker-in-endometrial-cancer
#15
Lucia Cicchillitti, Giacomo Corrado, Martina De Angeli, Emanuela Mancini, Ermelinda Baiocco, Lodovico Patrizi, Ashanti Zampa, Roberta Merola, Aline Martayan, Laura Conti, Giulia Piaggio, Enrico Vizza
Background: Altered circulating cell-free DNA (cfDNA) levels are related to cancer development and aggressiveness. Up to now, very few studies have been performed for evaluating cfDNA content in endometrial cancer (EC). Methods: First, we measured cfDNA release in blood serum of EC cancer patients collected before surgery and before the beginning of any treatment by SYBR Gold assay and correlated it with tumor aggressiveness. We also assessed the relative mitochondrial cell-free DNA (cfmtDNA) content by qRT-PCR...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29382392/serum-dna-integrity-index-as-a-potential-molecular-biomarker-in-endometrial-cancer
#16
Enrico Vizza, Giacomo Corrado, Martina De Angeli, Mariantonia Carosi, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Lodovico Patrizi, Ashanti Zampa, Giulia Piaggio, Lucia Cicchillitti
BACKGROUND: Circulating cell-free DNA (cfDNA) and its integrity index may represent a rapid and noninvasive "liquid biopsy" biomarker, which gives important complementary information for diagnosis, prognosis, and treatment stratification in cancer patients. The aim of our study was to evaluate the possible role of cfDNA and its integrity index as a complementary tool for endometrial cancer (EC) management. METHODS: Alu-quantitative real-time PCR (qPCR) analysis wasprformed on 60 serum samples from preoperative EC patients randomly recruited...
January 30, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29378567/does-a-provider-payment-method-affect-membership-retention-in-a-health-insurance-scheme-a-mixed-method-study-of-ghana-s-capitation-payment-for-primary-care
#17
Francis-Xavier Andoh-Adjei, Renske van der Wal, Eric Nsiah-Boateng, Felix Ankomah Asante, Koos van der Velden, Ernst Spaan
BACKGROUND: Ghana introduced a National Health Insurance Scheme (NHIS) in 2003 applying fee-for-service method for paying NHIS-credentialed health care providers. The National Health Insurance Authority (NHIA) later introduced diagnosis-related-grouping (DRG) payment to contain cost without much success. The NHIA then introduced capitation payment, a decision that attracted complaints of falling enrolment and renewal rates from stakeholders. This study was done to provide evidence on this trend to guide policy debate on the issue...
January 30, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29361986/perceived-causes-and-risk-factors-of-buruli-ulcer-among-patients-at-agogo-presbyterian-hospital-in-ashanti-region-of-ghana
#18
Reindolf Anokye, Enoch Acheampong, Wisdom Kwadwo Mprah, Edward Sarpong
OBJECTIVE: The incidence of Buruli ulcer has been recorded in about 30 countries globally and Africa seems to be the most affected area. The study sought to determine perceived causes and risk factors of Buruli ulcer among patients who visit the Agogo hospital in Asante-Akim North District in the Ashanti region of Ghana. A descriptive study design was adopted using a simple random sampling technique to select 400 patients attending The Presbyterian Hospital at Agogo. Data was collected using a structured questionnaire and analysed using SPSS version 16...
January 23, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29279463/sex-and-site-differences-in-urinary-excretion-of-conjugated-pyrene-metabolites-in-the-west-african-shorthorn-cattle
#19
Nesta Bortey-Sam, Yoshinori Ikenaka, Osei Akoto, Shouta M M Nakayama, Jemima T Marfo, Aksorn Saengtienchai, Hazuki Mizukawa, Mayumi Ishizuka
Industrialization, economic and population growth rates in Ghana have increased the release of contaminants including polycyclic aromatic hydrocarbons (PAHs) into the environment through which humans and animals are exposed. Cattle is reported to be exposed to high levels of PAHs through feed and inhalation. Once exposed, PAHs are metabolized and excreted in urine, feces or bile. In a previous study, cattle in Ghana was reported to excrete high levels of 1-hydroxypyrene (1-OHPyr) due to high exposure to the parent compound, pyrene...
March 2, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29244993/cervical-cancer-in-the-greater-accra-and-ashanti-regions-of-ghana
#20
Yvonne Nartey, Philip C Hill, Kwabena Amo-Antwi, Kofi M Nyarko, Joel Yarney, Brian Cox
Purpose Cervical cancer is a common cancer among women worldwide. An estimated 528,000 new cases and 266,000 deaths occurred in 2012. More than 85% of invasive cervical cancer cases occur in low- and middle-income countries. Cervical cancer ranks as the most common cancer among women in Ghana. We conducted a retrospective study to assess the descriptive epidemiology of cervical cancer in Ghana. We describe cervical cancer incidence and mortality rates for the regions served by two large hospitals in Ghana. Patients and Methods Information for women diagnosed with invasive cervical cancer between 2010 and 2013 was collected from the Komfo Anokye and Korle Bu Teaching Hospitals through review of medical, computer, and pathology records at the oncology units and the obstetrics and gynecology departments...
December 2017: Journal of Global Oncology
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