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https://www.readbyqxmd.com/read/29222347/pioglitazone-inhibits-periprostatic-white-adipose-tissue-inflammation-in-obese-mice
#1
Miki Miyazawa, Kotha Subbaramaiah, Priya Bhardwaj, Xi K Zhou, Hanhan Wang, Domenick J Falcone, Dilip D Giri, Andrew J Dannenberg
Obesity is associated with an increased incidence of high-grade prostate cancer (PC) and poor prognosis for PC patients. Recently, we showed that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by crown-like structures (CLS) consisting of dead or dying adipocytes surrounded by macrophages, was associated with high-grade PC. It's possible, therefore, that agents that suppress periprostatic WAT inflammation will alter the development or progression of PC. Pioglitazone, a ligand of PPARγ is used to treat diabetes and possesses anti-inflammatory properties...
December 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29211968/men-and-women-differ-in-the-biochemical-composition-of-platelet-rich-plasma
#2
Grace Xiong, Nithya Lingampalli, Jayme C B Koltsov, Lawrence L Leung, Nidhi Bhutani, William H Robinson, Constance R Chu
BACKGROUND: Autologous platelet-rich plasma (PRP) is widely used for a variety of clinical applications. However, clinical outcome studies have not consistently shown positive effects. The composition of PRP differs based on many factors. An improved understanding of factors influencing the composition of PRP is important for the optimization of PRP use. HYPOTHESIS: Age and sex influence the PRP composition in healthy patients. STUDY DESIGN: Controlled laboratory study...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29197248/the-role-of-il-8-cxcr2-signaling-in-microcystin-lr-triggered-endothelial-cell-activation-and-increased-vascular-permeability
#3
Limei Chen, Xiaoying Liu, Zhifang Pan, Shunmei Liu, Huirong Han, Chunling Zhao, Xuexi Tang
Microcystins are a family of cyclic heptapeptide toxins naturally produced by freshwater cyanobacteria. Microcystin-LR (MCLR) is believed to be the most toxic and common one with various pathological effects on human and mammals. However, the effects of MCLR on endothelial cells and vascular homeostasis have been largely unknown. We explored the mRNA and protein expression changes of several pro-inflammatory mediators in human umbilical vein endothelial cells (HUVECs) and C57BC/6 mice exposed to MCLR. Tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), especially interleukin-8 (IL-8) were remarkably upregulated both in endothelial cells and in serum...
November 25, 2017: Chemosphere
https://www.readbyqxmd.com/read/29188498/umbelliferone-alleviates-myocardial-ischemia-the-role-of-inflammation-and-apoptosis
#4
Jianxiang Gan, Weichun Qian, Song Lin
The present study was to investigate cardioprotective effects of umbelliferone (Umb) on coronary artery ligation-induced myocardial ischemia. The model of myocardial ischemia (MI) was induced by ligatured the left anterior descending coronary artery of SD rats. ST-segment elevation, lactate dehydrogenase (LDH), creatine kinase (CK), catalase (SOD), malondialdehyde (MDA), inflammatory cytokines, Toll-like receptors (TLRs)/nuclear factor (NF)-κBp65 pathway, and apoptosis were evaluated in rats treated with or without Umb...
November 29, 2017: Inflammation
https://www.readbyqxmd.com/read/29186870/dietary-supplementation-with-lactobacillus-casei-alleviates-lipopolysaccharide-induced-liver-injury-in-a-porcine-model
#5
Di Zhao, Tao Wu, Dan Yi, Lei Wang, Peng Li, Junmei Zhang, Yongqing Hou, Guoyao Wu
This study aims to determine whether Lactobacillus casei (L. casei) could relieve liver injury in piglets challenged with lipopolysaccharide (LPS). Piglets were randomly allocated into one of the three groups: control, LPS, and L. casei. The control and LPS groups were fed a corn- and soybean meal-based diet, whereas the L. casei group was fed the basal diet supplemented with 6 × 10⁶ cfu/g L. casei. On Day 31 of the trial, piglets in the LPS and L. casei groups received intraperitoneal administration of LPS (100 µg/kg body weight), while the control group received the same volume of saline...
November 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29184553/tumor-necrosis-factor-alpha-targeting-can-protect-against-arthritis-with-low-sensitization-to-infection
#6
Nadia Belmellat, Luca Semerano, Noria Segueni, Diane Damotte, Patrice Decker, Bernhard Ryffel, Valérie Quesniaux, Marie-Christophe Boissier, Eric Assier
Tumor necrosis factor-alpha (TNF-α) blockade is an effective treatment for rheumatoid arthritis (RA) and other inflammatory diseases, but in patients, it is associated with reduced resistance to the infectious agents Mycobacterium tuberculosis and Listeria monocytogenes, among others. Our goal was to model infection and arthritis in mice and to compare etanercept, a currently used anti-TNF-α inhibitor, to an anti-TNF-α vaccine. We developed a murine surrogate of the TNF-α kinoid and produced an anti-murine TNF-α vaccine (TNFKi) composed of keyhole limpet hemocyanin conjugated to TNF-α, which resulted in anti-TNF-α antibody production in mice...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29183282/bilateral-muscle-fiber-and-nerve-influences-by-tnf-alpha-in-response-to-unilateral-muscle-overuse-studies-on-tnf-receptor-expressions
#7
Lina Renström, Per Stål, Yafeng Song, Sture Forsgren
BACKGROUND: TNF-alpha is suggested to be involved in muscle damage and muscle inflammation (myositis). In order to evaluate whether TNF-alpha is involved in the myositis that occurs in response to muscle overuse, the aim was to examine the expression patterns of TNF receptors in this condition. METHODS: A rabbit muscle overuse model leading to myositis in the soleus muscle was used. The expression patterns of the two TNF receptors Tumor Necrosis Factor Receptor type 1 (TNFR1) and Tumor Necrosis Factor Receptor type 2 (TNFR2) were investigated...
November 28, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29179168/-the-impact-of-controlling-bone-remodeling-in-rheumatoid-arthritis
#8
Kosuke Ebina
Rheumatoid arthritis(RA)is associated with increased bone turnover and early bone loss, which lead to increased fracture risk and progressive joint destruction. Pro-inflammatory cytokines, such as IL(interleukin)-17, TNF-α(tumor necrosis factor alpha), IL-1, and IL-6 induce the expression of RANKL(receptor activation of nuclear factor κB ligand)from synovial fibroblasts. RANKL promotes osteoclasts differentiation and activation, and Denosumab, an anti-RANKL monoclonal antibody, inhibits both systemic bone loss and focal bone erosion of RA...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29170425/tradd-mediates-the-tumor-necrosis-factor-induced-apoptosis-of-l929-cells-in-the-absence-of-rip3
#9
Xixi Chang, Lili Wang, Zicheng Wang, Shuai Wu, Xiaoming Zhu, Shiping Hu, Yu Wang, Jiyun Yu, Guozhu Chen
Receptor-interacting protein kinase 3 (RIP3) is a critical initiator in mediating necroptosis induced by tumor necrosis factor alpha (TNFα) in L929 cells, so knockdown of RIP3 inhibits TNFα-induced L929 cell necroptosis. However, RIP3 knockdown was shown to switch TNFα-induced necroptosis to apoptosis in L929 cells in other studies. Therefore, whether RIP3 knockdown blocks the TNFα-induced death of L929 cells is controversial. In this study, TNFα activated caspase pathway and induced cell death in RIP3 knockdown L929 cells, and the RIP3-independent cell death had been blocked by Z-VAD-FMK (pan-caspase inhibitor) or caspase 8 knockdown, demonstrating that RIP3 knockdown switched TNFα-induced necroptosis to caspase-dependent apoptosis...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29164277/high-prevalence-of-dengue-antibodies-and-the-arginine-variant-of-the-fc%C3%AE-riia-polymorphism-in-asymptomatic-individuals-in-a-population-of-minas-gerais-state-southeast-brazil
#10
Anna Carolina Toledo da Cunha Pereira, Tatiane Ribeiro de Siqueira, Andressa Anunciação de Oliveira Prado, Camila Almeida Veiga da Silva, Thaís de Fátima Silva Moraes, Alan Alex Aleixo, José Carlos de Magalhaes, Gabriel Augusto Pires de Souza, Betânia Paiva Drumond, Gustavo Portela Ferreira, Breno de Mello Silva, Cintia Lopes de Brito Magalhães, Luciana Lara Santos, Jaqueline Maria Siqueira Ferreira, Luiz Cosme Cotta Malaquias, Luiz Felipe Leomil Coelho
Dengue is the most prevalent arthropod-borne viral illness in humans worldwide. Single-nucleotide polymorphisms (SNPs) in genes involved in the immune response, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), IgG Fc receptor II-A (FcγRIIa), vitamin D receptor (VDR), and tumor necrosis factor alpha (TNF-α), were previously reported to be associated with susceptibility to dengue disease in different human populations. Therefore, due to the relevant association of host immune and genetic status with disease susceptibility/severity of dengue, this work aims to verify the frequency of anti-dengue virus antibodies and some dengue-associated risk SNPs in a population in Minas Gerais State, Southeast Brazil...
November 21, 2017: Immunogenetics
https://www.readbyqxmd.com/read/29163548/emodin-alleviates-sodium-taurocholate-induced-pancreatic-acinar-cell-injury-via-microrna-30a-5p-mediated-inhibition-of-high-temperature-requirement-a-transforming-growth-factor-beta-1-inflammatory-signaling
#11
Hong Xiang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Dong Shang
Pancreatitis is an inflammatory disease that is responsible for substantial morbidity and mortality, and it can induce pancreatic necrosis that starts within pancreatic acinar cells in severe cases. Emodin, a pleiotropic natural product isolated from the Chinese herb Rheum palmatum L., has effective anti-inflammatory activities. In this paper, we investigated the protective effects and molecular mechanism of emodin against sodium taurocholate (STC)-induced pancreatic acinar cells injury in vitro and in vivo; and the results showed that emodin could significantly alleviate STC-induced pancreatic acinar cells injury through decreasing trypsin, amylase and the release of inflammatory factors (tumor necrosis factor alpha, interleukin-1β, and interleukin-6)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29152323/new-melanocortin-like-peptide-of-e-coli-can-suppress-inflammation-via-the-mammalian-melanocortin-1-receptor-mc1r-possible-endocrine-like-function-for-microbes-of-the-gut
#12
Xiaoling Qiang, Anthony S Liotta, Joseph Shiloach, J C Gutierrez, Haichao Wang, Mahendar Ochani, Kanta Ochani, Huan Yang, Aviva Rabin, Derek LeRoith, Maxine A Lesniak, Markus Böhm, Christian Maaser, Klaus Kannengiesser, Mark Donowitz, Shervin Rabizadeh, Christopher J Czura, Kevin J Tracey, Mark Westlake, Aida Zarfeshani, Syed F Mehdi, Ann Danoff, Xueliang Ge, Suparna Sanyal, Gary J Schwartz, Jesse Roth
E. coli releases a 33 amino acid peptide melanocortin-like peptide of E. coli (MECO-1) that is identical to the C-terminus of the E. coli elongation factor-G (EF-G) and has interesting similarities to two prominent mammalian melanocortin hormones, alpha-melanocyte-stimulating hormone (alpha-MSH) and adrenocorticotropin (ACTH). Note that MECO-1 lacks HFRW, the common pharmacophore of the known mammalian melanocortin peptides. MECO-1 and the two hormones were equally effective in severely blunting release of cytokines (HMGB1 and TNF) from macrophage-like cells in response to (i) endotoxin (lipopolysaccharide) or (ii) pro-inflammatory cytokine HMGB-1...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29149648/dried-plum-alleviates-symptoms-of-inflammatory-arthritis-in-tnf-transgenic-mice
#13
Faryal Mirza, Joseph Lorenzo, Hicham Drissi, Francis Y Lee, Do Y Soung
Dried plum (DP), a rich source of polyphenols has been shown to have bone-preserving properties in both animal models of osteoporosis and postmenopausal women. We evaluated if DP alleviated the destruction of joints in transgenic mice (TG) that overexpress human tumor necrosis factor (TNF), a genetic model of rheumatoid arthritis (RA). A four-week treatment of 20% DP diet in TG slowed the onset of arthritis and reduced bone erosions in the joints compared to TG on a regular diet. This was associated with fewer tartrate-resistant acid phosphatase (TRAP) positive cells, suggesting decreased osteoclastogenesis...
October 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29142497/expression-of-ccl2-and-its-receptor-in-activation-and-migration-of-microglia-and-monocytes-induced-by-photoreceptor-apoptosis
#14
ChaoYi Feng, Xin Wang, TianJin Liu, Meng Zhang, GeZhi Xu, YingQin Ni
Purpose: To explore the effect of the CCL2 and CCR2 system on the activation and migration of microglia and monocytes in light-induced photoreceptor apoptosis. Methods: At 1 day, 3 days, 7 days, and 14 days after light exposure, OX42 and ED1 immunostaining were used to label the activation and migration of microglia and monocytes. Double immunostaining of CCL2 with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), OX42, or glial fibrillary acidic protein (GFAP) was applied to explore the relationships among CCL2, apoptotic photoreceptors, activated microglia and monocytes, and macroglial cells (Müller cells and astrocytes)...
2017: Molecular Vision
https://www.readbyqxmd.com/read/29142404/chalepin-a-compound-from-ruta-angustifolia-l-pers-exhibits-cell-cycle-arrest-at-s-phase-suppresses-nuclear-factor-kappa-b-nf-%C3%AE%C2%BAb-pathway-signal-transducer-and-activation-of-transcription-3-stat3-phosphorylation-and-extrinsic-apoptotic-pathway-in-non-small-cell
#15
Jaime Stella Moses Richardson, Norhaniza Aminudin, Sri Nurestri Abd Malek
Background: Plants have been a major source of inspiration in developing novel drug compounds in the treatment of various diseases that afflict human beings worldwide. Ruta angustifolia L. Pers known locally as Garuda has been conventionally used for various medicinal purposes such as in the treatment of cancer. Objective: A dihydrofuranocoumarin named chalepin, which was isolated from the chloroform extract of the plant, was tested on its ability to inhibit molecular pathways of human lung carcinoma (A549) cells...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29130055/gene-therapy-with-hsv-encoding-p55tnfr-gene-for-hiv-neuropathic-pain-an-evidence-based-mini-review
#16
Hirotsugu Kanda, Shue Liu, Megumi Kanao, Hyun Yi, Takafumi Iida, Wan Huang, Takayuki Kunisawa, David A Lubarsky, Shuanglin Hao
While effective antiretroviral treatment makes human immunodeficiency virus (HIV)-related death decreased dramatically, neuropathic pain becomes one of the most common complications in patients with HIV/acquired immunodeficiency syndrome (AIDS). The exact mechanisms of HIV-related neuropathic pain are not well understood yet, and no effective therapy is for HIV-pain. Evidence has shown that proinflammatory factors (e.g., tumor necrosis factor alpha (TNFα)) released from glia, are critical to contributing to chronic pain...
2017: Translational Perioperative and Pain Medicine
https://www.readbyqxmd.com/read/29128925/transcriptome-profile-analysis-reveals-cardiotoxicity-of-maduramicin-in-primary-chicken-myocardial-cells
#17
Xiuge Gao, Lin Peng, Xiangchun Ruan, Xin Chen, Hui Ji, Junxiao Ma, Han Ni, Shanxiang Jiang, Dawei Guo
Maduramicin, an excellent ionophore antibiotic, is extensively used to control coccidiosis in poultry. Numerous maduramicin intoxications have been reported in farm animal and human due to its relatively narrow safety range, with necrosis or degeneration of cardiac and skeletal muscles as hallmark. To date, the mechanisms of maduramicin-induced cardiotoxicity remain unclear in chicken and other animals. Maduramicin (5 µg/mL)-treated primary chicken myocardial cells were used for RNA sequencing (RNA-Seq) and bioinformatics analysis in this study...
November 11, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29127662/jnj7777120-ameliorates-inflammatory-and-oxidative-manifestations-in-a-murine-model-of-contact-hypersensitivity-via-modulation-of-tlr-and-nrf2-signaling
#18
Ahmed F Mohamed, Mohammed F El-Yamany, Fatma A El-Batrawy, Mohamed T Abdel-Aziz
JNJ7777120, a histamine H4 receptor antagonist, was shown to be effective in different experimental settings of allergic inflammation, including contact hypersensitivity. Toll-like receptors (TLRs) are thought to function as a link between innate and adaptive immune responses to various haptens. Here, we studied the suppression of TLR signaling as a possible mechanism by which JNJ7777120 exerts its anti-inflammatory effects against the chemical hapten, fluorescein isothiocyanate (FITC). The potential anti-oxidant effect of JNJ7777120 in this model was also examined...
November 10, 2017: Inflammation
https://www.readbyqxmd.com/read/29125100/effects-of-force-and-inflammatory-factors-on-the-expressions-of-osteogenesis-regulators-in-human-periodontal-ligament-cells
#19
Hua-Jing Zhang, Sheng-Nan Li, Xiao-Nan Xu, Ding Zhang
Objective To observe the effects of force signals and inflammatory cytokines on the expressions of functional proteins during the differentiation of periodontal ligament cells(PDLCs) into osteoclasts. Methods The caries-free premolars that needed to be removed for orthodontic treatment were collected,human periodontal ligament cells were cultured in vitro.Human PDLCs were exposed to inflammatory cytokines including interleukin(IL)-1β,-6,-23,and tumor necrosis factor alpha(TNF-α). Cyclicmechanical tension with a maximum 5% elongation for different durations(0,2,4,8,12,and 24 hours) were applied...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29113143/sevoflurane-postconditioning-induced-anti-inflammation-via-inhibition-of-the-toll-like-receptor-4-nuclear-factor-kappa-b-pathway-contributes-to-neuroprotection-against-transient-global-cerebral-ischemia-in-rats
#20
Jung-Won Hwang, Young-Tae Jeon, Young-Jin Lim, Hee-Pyoung Park
The anti-inflammatory actions of sevoflurane postconditioning are suggested as an important mechanism of sevoflurane postconditioning-induced neuroprotection against cerebral ischemia. Here, we determined whether the anti-inflammatory effects of sevoflurane postconditioning were mediated via inhibition of the toll-like receptor (TLR)-4/nuclear factor kappa B (NF-κB) pathway after global transient cerebral ischemia in rats. Forty-five rats were randomly assigned to five groups as follows: (1) control (10 min of ischemia, n = 10); (2) sevoflurane postconditioning (two periods of sevoflurane inhalation after ischemia for 10 min with a wash period of 10 min, n = 10); (3) resatorvid (intraperitoneal injection of a selective TLR-4 antagonist (3 mg/kg) 30 min before ischemia, n = 10); (4) sevoflurane postconditioning plus resatorvid (n = 10), and sham (n = 5)...
November 6, 2017: International Journal of Molecular Sciences
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