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https://www.readbyqxmd.com/read/29925372/selenium-ameliorates-staphylococcus-aureus-induced-inflammation-in-bovine-mammary-epithelial-cells-by-inhibiting-activation-of-tlr2-nf-%C3%AE%C2%BAb-and-mapk-signaling-pathways
#1
Heng Wang, Chongliang Bi, Yinjie Wang, Jun Sun, Xia Meng, Jianji Li
BACKGROUND: Staphylococcus aureus (S. aureus) internalization into bovine mammary epithelial cells (bMECs) is considered an important pathogenic mechanism for the establishment of mastitis. Given the interesting link between selenium (Se) status and mastitis, our objective was to prove that Se was essential to suppress pro-inflammatory mediators, in part, by modulation of Toll-like receptor2 (TLR2), nuclear factor kappaB (NF-κB) and mitogen activated protein kinase (MAPK) signal transduction pathway in bMECs...
June 20, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29922282/cord-blood-cd8-t-cells-have-a-natural-propensity-to-express-il-4-in-a-fatty-acid-metabolism-and-caspase-activation-dependent-manner
#2
Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison
How T cells differentiate in the neonate may critically determine the ability of the infant to cope with infections, respond to vaccines and avert allergies. Previously, we found that naïve cord blood CD4+ T cells differentiated toward an IL-4-expressing phenotype when activated in the presence of TGF-β and monocyte-derived inflammatory cytokines, the latter are more highly secreted by infants who developed food allergy. Here, we show that in the absence of IL-2 or IL-12, naïve cord blood CD8+ T cells have a natural propensity to differentiate into IL-4-producing non-classic TC 2 cells when they are activated alone, or in the presence of TGF-β and/or inflammatory cytokines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29912899/association-of-hogg1-ser326cys-itga2-c807t-tnf-a-308g-a-and-xpd-lys751gln-polymorphisms-with-the-survival-of-malaysian-npc-patients
#3
Eng-Zhuan Ban, Munn-Sann Lye, Pei Pei Chong, Yoke-Yeow Yap, Siew Ying Crystale Lim, Hejar Abdul Rahman
BACKGROUND: Nasopharyngeal carcinoma is a rare form of cancer across the world except in certain areas such as Southern China, Hong Kong and Malaysia. NPC is considered a relatively radiosensitive tumor and patients diagnosed at early stages tend to survive longer compared to those with advanced disease. Given that early symptoms of NPC are non-specific and that the nasopharynx is relatively inaccessible, less invasive screening methods such as biomarker screening might be the key to improve NPC survival and management...
2018: PloS One
https://www.readbyqxmd.com/read/29910805/ip-10-promotes-blood-brain-barrier-damage-by-inducing-tumor-necrosis-factor-alpha-production-in-japanese-encephalitis
#4
Ke Wang, Haili Wang, Wenjuan Lou, Longhuan Ma, Yunchuan Li, Nan Zhang, Chong Wang, Fang Li, Muhammad Awais, Shengbo Cao, Ruiping She, Zhen F Fu, Min Cui
Japanese encephalitis is a neuropathological disorder caused by Japanese encephalitis virus (JEV), which is characterized by severe pathological neuroinflammation and damage to the blood-brain barrier (BBB). Inflammatory cytokines/chemokines can regulate the expression of tight junction (TJ) proteins and are believed to be a leading cause of BBB disruption, but the specific mechanisms remain unclear. IP-10 is the most abundant chemokine produced in the early stage of JEV infection, but its role in BBB disruption is unknown...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29909460/modulation-of-brain-ace-and-ace2-may-be-a-promising-protective-strategy-against-cerebral-ischemia-reperfusion-injury-an-experimental-trial-in-rats
#5
Maha Mohammed Abdel-Fattah, Basim Anwar Shehata Messiha, Ahmed Mohamed Mansour
The brain renin-angiotensin system (RAS) is considered a crucial regulator for physiological homeostasis and disease progression. We evaluated the protective effects of the angiotensin receptor blocker (ARB) telmisartan and the angiotensin-converting enzyme 2 (ACE2) activator xanthenone on experimental cerebral ischemia/reperfusion (I/R) injury. Rats were divided into a sham control, a cerebral I/R control, a standard treatment (nimodipine, 10 mg/kg/day, 15 days, p.o.), three telmisartan treatments (1, 3, and 10 mg/kg/day, 15 days, p...
June 17, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29905411/anti-inflammatory-and-antioxidant-effects-of-mesenchymal-and-hematopoietic-stem-cells-in-a-rheumatoid-arthritis-rat-model
#6
Hanan Abdelmawgoud, Asmaa Saleh
BACKGROUND: Mesenchymal stem cells (MSCs) are of increased importance because of their capacity to counteract inflammation and suppress host immune responses. OBJECTIVES: The aim of the study was to compare the effectiveness of MSCs and hematopoietic stem cells (HSCs) in the treatment of rheumatoid arthritis (RA). MATERIAL AND METHODS: Paw swelling was assessed by measuring the thickness of the hind paws using a caliper. Cytokines - interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and IL-10 - and rheumatoid factor (RF) were measured using enzyme-linked immunosorbent assay (ELISA) kits...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29903983/4-methoxyresveratrol-alleviated-age-induced-inflammation-via-rage-mediated-nf-%C3%AE%C2%BAb-and-nlrp3-inflammasome-pathway
#7
Wenzhe Yu, Mengru Tao, Yueliang Zhao, Xiaoqian Hu, Mingfu Wang
Advanced glycation end products (AGEs) could interact with the receptor for AGE (RAGE) as a sterile danger signal to induce inflammation. 4′-methoxyresveratrol (4′MR), a polyphenol derived from Dipterocarpaceae, has not been studied for its anti-inflammation effects. In the present study, we sought to explore the protective role of 4′MR in AGEs-induced inflammatory model using RAW264.7 macrophages. 4′MR significantly inhibited gene expression of pro-inflammatory cytokines and chemokines, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α) and monocyte chemoattractant protein-1 (MCP-1), as well as two typical pro-inflammatory enzymes, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2)...
June 14, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29894705/plasma-biomarkers-in-a-placebo-controlled-trial-comparing-tdcs-and-escitalopram-efficacy-in-major-depression
#8
André R Brunoni, Frank Padberg, Erica Leandro Marciano Vieira, Antônio Lucio Teixeira, André F Carvalho, Paulo Andrade Lotufo, Wagner F Gattaz, Isabela Martins Benseñor
BACKGROUND: Transcranial direct current stimulation (tDCS) holds promise as a therapeutic intervention for major depressive disorder (MDD). A more precise understanding of its underlying mechanisms may aid in the identification of subsets of patients responsive to tDCS within the context of precision psychiatry. OBJECTIVE: In this ancillary investigation of the Escitalopram vs. Electrical Current Therapy for Treating Depression Clinical Study (ELECT-TDCS), we investigated whether plasma levels of several cytokines and neurotrophic factors associated with major depression or antidepressant response predicted tDCS effects...
June 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29890246/l-homocarnosine-attenuates-inflammation-in-cerebral-ischemia-reperfusion-injury-through-inhibition-of-nod-like-receptor-protein-3-inflammasome
#9
Jing Huang, Tao Wang, Daorui Yu, Xingyue Fang, Haofei Fan, Qiang Liu, Guohui Yi, Xinan Yi, Qibin Liu
We investigated the therapeutic effects of l-homocarnosine against inflammation in a rat model of cerebral ischemia-reperfusion injury. Rats were grouped into control, middle cerebral artery occlusion (MCAO), 0.5 mM l-homocarnosine + MCAO, and 1 mM l-homocarnosine + MCAO treatment groups. Superoxide dismutase (SOD), glutathione peroxidase (Gpx), catalase, lipid peroxidation, and reduced glutathione (GSH) levels were measured. Neurological scores were assessed, and histopathology, scanning electron microscopy (SEM), and fluorescence microscopy analyses were conducted...
June 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29889817/alpha-1-adrenergic-receptor-agonist-phenylephrine-inhibits-sepsis-induced-cardiomyocyte-apoptosis-and-cardiac-dysfunction-via-activating-erk1-2-signal-pathaway
#10
Hongmei Li, Yun Xing, Duomeng Yang, Xiangxu Tang, Daxiang Lu, Huadong Wang
It was demonstrated that α1 adrenergic receptor (α1-AR) activation by phenylephrine (PE) attenuated cardiac dysfunction in lipopolysaccharide (LPS) - challenged mice. However, it is unclear whether PE suppresses sepsis-induced cardiomyocyte apoptosis. Here, we investigated the effects of PE on cardiomyocyte apoptosis in LPS-treated adult rat ventricular myocytes (ARVMs) and septic rats induced by cecal ligation and puncture. Cardiomyocyte apoptosis and caspase activity were detected by TUNEL and spectrophotometrical assay, respectively...
June 8, 2018: Shock
https://www.readbyqxmd.com/read/29888839/cd56-bright-natural-killer-cells-induce-hbsag-reduction-via-cytolysis-and-cccdna-decay-in-long-term-entecavir-treated-patients-switching-to-peginterferon-alfa-2a
#11
Aichao Shi, Xiaoping Zhang, Fang Xiao, Lin Zhu, Weiming Yan, Meifang Han, Xiaoping Luo, Tao Chen, Qin Ning
HBV surface antigen (HBsAg) reduction is well observed in chronic hepatitis B (CHB) patients treated with pegylated interferon-alpha-2a (Peg-IFNα). However, the mechanism of HBsAg suppression has not been fully elucidated. Twenty-seven of 55 Entecavir-treated CHB e antigen positive patients were switched to Peg-IFNα treatment (Group A) whereas 28 patients continued entecavir treatment (Group B). The percentage or absolute number of CD56bright /CD56dim NK cells, expression of receptors and cytokines were evaluated by flow cytometry for 48 weeks and correlated with treatment efficacy...
June 11, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29883374/anti-inflammatory-effects-of-angelica-sinensis-oliv-diels-water-extract-on-raw-264-7-induced-with-lipopolysaccharide
#12
Young-Jin Kim, Ji Young Lee, Hyun-Ju Kim, Do-Hoon Kim, Tae Hee Lee, Mi Suk Kang, Wansu Park
The dry root of Angelica sinensis (Oliv.) Diels, also known as “female ginseng”, is a popular herbal drug amongst women, used to treat a variety of health issues and cardiovascular diseases. The aim of this study is to evaluate the detailed molecular mechanism for anti-inflammatory effects of Angelica sinensis root water extract (ASW). The anti-inflammatory effect of ASW on lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophages was evaluated by the tetrazolium-based colorimetric assay (MTT), Griess reagent assay, multiplex cytokine assay, real time reverse transcription polymerase chain reaction (RT-PCR), and Fluo-4 calcium assay...
May 21, 2018: Nutrients
https://www.readbyqxmd.com/read/29877106/polysaccharides-from-citrus-grandis-associate-with-luteolin-relieves-chronic-pharyngitis-by-anti-inflammatory-via-suppressing-nf-%C3%AE%C2%BAb-pathway-and-the-polarization-of-m1-macrophages
#13
Xiumei Chen, Yongfeng Lai, Xicheng Song, Jinying Wu, Li Wang, Hua Zhang, Zhonglu Liu, Yan Wang
Chronic pharyngitis is characterized as a common inflammation of the pharyngeal mucosa, and anti-inflammatory medications are the common treatment to relieve it. Polysacharides of Citrus grandis L. Osbeck (PCG) and luteolin have been reported to have anti-inflammatory activities. In this study, the protective effects of PCG and luteolin on chronic pharyngitis are evaluated and the underlying mechanisms are explored. PCG and luteolin are administrated to animal models with granuloma, ear edema and chronic pharyngitis and the effects of PCG and luteolin on disease severity are evaluated...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29872582/high-mobility-group-box-1-hmgb1-acts-as-an-alarmin-to-promote-acute-myeloid-leukaemia-progression
#14
Inna M Yasinska, Isabel Gonçalves Silva, Svetlana S Sakhnevych, Laura Ruegg, Rohanah Hussain, Giuliano Siligardi, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Ulrike Raap, Steffen Berger, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev
High mobility group box 1 (HMGB1) is a non-histone protein localised in the cell nucleus, where it interacts with DNA and promotes nuclear transcription events. HMGB1 levels are elevated during acute myeloid leukaemia (AML) progression followed by participation of this protein in triggering signalling events in target cells as a pro-inflammatory stimulus. This mechanism was hypothesised to be employed as a survival pathway by malignant blood cells and our aims were therefore to test this hypothesis experimentally...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29872403/circulating-endothelial-progenitor-cells-present-an-inflammatory-phenotype-and-function-in-patients-with-alcoholic-liver-cirrhosis
#15
Savneet Kaur, Rashi Sehgal, Saggere M Shastry, Geoffrey McCaughan, Helen M McGuire, Barbara Fazekas St de Groth, Shiv Sarin, Nirupma Trehanpati, Devanshi Seth
Background and Aim: Endothelial progenitor cells (EPCs) have been implicated in liver injury and repair. However, the phenotype and potential of these heterogenous EPCs remain elusive. In particular, their involvement in the pathogenesis of alcoholic liver cirrhosis (ALC) remains unclear. The current study extensively characterized the phenotype and functions of EPCs to understand their role in ALC pathogenesis. Methods: Circulating EPCs were identified as CD34+CD133+CD31+ cells by flow cytometer in ALC patients ( n = 7) and healthy controls (HC, n = 7)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29870816/a-novel-diindolylmethane-analog-1-1-bis-3-indolyl-1-p-chlorophenyl-methane-inhibits-the-tumor-necrosis-factor-induced-inflammatory-response-in-primary-murine-synovial-fibroblasts-through-a-nurr1-dependent-mechanism
#16
Maryam F Afzali, Katriana A Popichak, Lindsey H Burton, Anna L Klochak, William J Wilson, Stephen Safe, Ronald B Tjalkens, Marie E Legare
The progression of rheumatoid arthritis involves the thickening of the synovial lining due to the proliferation of fibroblast-like synoviocytes (FLS) and infiltration by inflammatory cells. Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine involved in progression of the disease. Under rheumatoid conditions, FLS express the tumor necrosis factor (TNF)-recognition complex (TNFR1, TNFR2, VCAM-1 and ICAM-1), which induces local macrophage activation and leads to downstream nuclear factor κB (NF-κB) signaling...
June 2, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29867706/ursolic-acid-ameliorates-inflammation-in-cerebral-ischemia-and-reperfusion-injury-possibly-via-high-mobility-group-box-1-toll-like-receptor-4-nf%C3%AE%C2%BAb-pathway
#17
Yanzhe Wang, Lei Li, Shumin Deng, Fang Liu, Zhiyi He
Toll-like receptors (TLRs) play key roles in cerebral ischemia and reperfusion injury by inducing the production of inflammatory mediators, such as interleukins (ILs) and tumor necrosis factor-alpha (TNF-α). According to recent studies, ursolic acid (UA) regulates TLR signaling and exhibits notable anti-inflammatory properties. In the present study, we explored the mechanism by which UA regulates inflammation in the rat middle cerebral artery occlusion and reperfusion (MCAO/R) model. The MCAO/R model was induced in male Sprague-Dawley rats (MCAO for 2 h, followed by reperfusion for 48 h)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29867481/arctigenin-induces-an-activation-response-in-porcine-alveolar-macrophage-through-tlr6-nox2-mapks-signaling-pathway
#18
Zheng Lu, Lingling Chang, Qian Du, Yong Huang, Xiujuan Zhang, Xingchen Wu, Jie Zhang, Ruizhen Li, Zelin Zhang, Wenlong Zhang, Xiaomin Zhao, Dewen Tong
Arctigenin (ARG), one of the most active ingredients abstracted from seeds of Arctium lappa L. , has been proved to exert promising biological activities such as immunomodulatory, anti-viral, and anti-cancer etc. However, the mechanism behind its immunomodulatory function still remains elusive to be further investigated. In this study, we found that ARG had no significant effects on the cell proliferation in both porcine alveolar macrophage cell line (3D4/21) and primary porcine derived alveolar macrophage...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29862528/estrogen-related-receptor-alpha-triggers-the-proliferation-and-migration-of-human-non-small-cell-lung-cancer-via-interleukin-6
#19
Jing Zhang, Xiangqian Guan, Naixin Liang, Shanqing Li
Human non-small cell lung cancer (NSCLC) is one of the leading causes of cancer deaths worldwide. Estrogenic signals have been suggested to be important for the growth and metastasis of NSCLC cells. Our present data showed that estrogen-related receptor alpha (ERRα), while not ERRβ or ERRγ, was significantly elevated in NSCLC cell lines as compared with that in normal bronchial epithelial cell line BEAS-2B. The expression of ERRα in clinical NSCLC tissues was significantly greater than that in their matched normal adjacent tissues...
June 3, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29850502/a-single-codon-optimization-enhances-recombinant-human-tnf-%C3%AE-vaccine-expression-in-escherichia-coli
#20
Chu Chu, Wangqian Zhang, Jialin Li, Yi Wan, Zenglu Wang, Ruyi Duan, Pei Yu, Ning Zhao, Kuo Zhang, Shuning Wang, Qiang Hao, Weina Li, Cun Zhang, Wei Zhang, Yingqi Zhang, Meng Li, Xiaochang Xue
As a proinflammatory cytokine, tumor necrosis factor-alpha (TNF- α ) plays a pivotal role in various autoimmune diseases such as rheumatoid arthritis (RA). Thus, TNF- α has been defined as a therapeutic target for RA. Although some TNF- α antagonists including neutralizing monoclonal antibodies and soluble receptors have been approved to be successful in attenuating symptoms in patients suffering from RA, the long-term use of these passive immunization reagents could cause some problems like a variable degree of immunogenicity...
2018: BioMed Research International
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