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systolic blood pressure intervention trial

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https://www.readbyqxmd.com/read/28724309/effects-of-long-term-device-guided-slow-breathing-on-sympathetic-nervous-activity-in-hypertensive-patients-a-randomized-open-label-clinical-trial
#1
Silvana de Barros, Giovanio Vieira da Silva, Josiane Lima de Gusmão, Tatiana Goveia de Araújo, Dinoélia Rosa de Souza, Crivaldo Gomes Cardoso, Bruna Oneda, Décio Mion
PURPOSE: Device-guided slow breathing (DGB) is indicated as nonpharmacological treatment for hypertension. The sympathetic nerve activity (SNA) reduction may be one of the mechanisms involved in blood pressure (BP) decrease. The aim of this study is to evaluate the long-term use of DGB in BP and SNA. SUBJECTS AND METHODS: Hypertensive patients were randomized to listen music (Control Group-CG) or DGB (aim to reduce respiratory rate to less than 10 breaths/minute during 15 minutes/day for 8 weeks)...
July 20, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28722271/beyond-glycemic-control-a-cross-over-double-blind-24-week-intervention-with-liraglutide-in-type-1-diabetes
#2
M-C Dubé, M D'Amours, S J Weisnagel
AIMS: To investigate the effects of 24 weeks of treatment with liraglutide added to basal/bolus insulin on anthropometric and metabolic parameters in overweight participants with type 1 diabetes. METHODS: In a double-blind cross-over fashion, 15 participants were randomly assigned (1:1) to receive placebo (saline solution) or liraglutide for 24 weeks including a one-month titration period from 0.6 mg to 1.2 mg to 1.8 mg, in addition to their insulin. The treatment was followed by a 1 month wash-out period...
July 18, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28720121/the-effectiveness-of-daily-sms-reminders-in-pharmaceutical-care-of-older-adults-on-improving-patients-adherence-to-antihypertensive-medication-sppa-study-protocol-for-a-randomized-controlled-trial
#3
Zuzana Haramiova, Michal Stasko, Martin Hulin, Tomas Tesar, Magdalena Kuzelova, Donald M Morisky
BACKGROUND: Despite a variety of efficient and cost-effective antihypertensive medication, hypertension remains a serious health and economic burden. High consumption of cardiovascular drugs in the Slovak Republic does result neither in better hypertension control nor in significant decrease in cardiovascular mortality. At the same time, Slovakia has alarmingly low patients' adherence to medication intake. Studies have shown the efficiency of short messaging service (SMS) reminders to improve patients' adherence and health outcomes at low costs...
July 18, 2017: Trials
https://www.readbyqxmd.com/read/28716046/blood-volume-monitored-regulation-of-ultrafiltration-to-decrease-the-dry-weight-in-fluid-overloaded-hemodialysis-patients-a-randomized-controlled-trial
#4
Marlies Antlanger, Peter Josten, Michael Kammer, Isabella Exner, Katharina Lorenz-Turnheim, Manfred Eigner, Gernot Paul, Renate Klauser-Braun, Gere Sunder-Plassmann, Marcus D Säemann, Manfred Hecking
BACKGROUND: Because chronic fluid volume overload is associated with higher mortality, we tested whether blood-volume monitored regulation of ultrafiltration and dialysate conductivity (UCR) and/or regulation of ultrafiltration and temperature (UTR) would facilitate dry weight reduction, in comparison to conventional dialysis (CONV). METHODS: We carried out a multicenter, 4-week, randomized controlled trial in hemodialysis patients ≥15% above normal extracellular fluid volume (ECV), per bioimpedance spectroscopy, who were randomized 1:1:1...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28710205/effect-of-interdisciplinary-care-on-weight-loss-a-randomised-controlled-trial
#5
Linda C Tapsell, Maureen Lonergan, Marijka J Batterham, Elizabeth P Neale, Allison Martin, Rebecca Thorne, Frank Deane, Gregory Peoples
OBJECTIVE: To determine the effectiveness of a novel interdisciplinary treatment compared with usual care on weight loss in overweight and obese adult volunteers. DESIGN: Single blinded controlled trial. Participants randomly assigned to usual care (C, general guideline-based diet and exercise advice), intervention (I, interdisciplinary protocol) or intervention + a healthy food supplement (30 g walnuts/day) (IW). SETTING: Community based study, Illawarra region, south of Sydney, Australia...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28707234/the-elusive-search-for-optimal-blood-pressure-targets
#6
REVIEW
Alan H Gradman
BP treatment thresholds/targets determine when to initiate treatment and to what level BP should be reduced. The Seventh Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7) recommended a target of <140/90 for most patients and a target <130/80 mmHg for patients with diabetes or chronic kidney disease. Subsequently, meta-analyses, retrospective studies relating on-treatment BP to clinical outcomes and two large, randomized clinical trials (RCTs) have re-evaluated BP targets...
August 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28704405/community-health-workers-for-non-communicable-diseases-prevention-and-control-in-developing-countries-evidence-and-implications
#7
Gursimer Jeet, J S Thakur, Shankar Prinja, Meenu Singh
BACKGROUND: National programs for non-communicable diseases (NCD) prevention and control in different low middle income countries have a strong community component. A community health worker (CHW) delivers NCD preventive services using informational as well as behavioural approaches. Community education and interpersonal communication on lifestyle modifications is imparted with focus on primordial prevention of NCDs and screening is conducted as part of early diagnosis and management...
2017: PloS One
https://www.readbyqxmd.com/read/28701992/verifying-the-relative-efficacy-between-continuous-positive-airway-pressure-therapy-and-its-alternatives-for-obstructive-sleep-apnea-a-network-meta-analysis
#8
Tingwei Liu, Wenyang Li, Hui Zhou, Zanfeng Wang
Obstructive sleep apnea (OSA) is a common breathing disorder, and continuous positive airway pressure (CPAP) therapy together with its alternatives has been developed to treat this disease. This network meta-analysis (NMA) was aimed to compare the efficacy of treatments for OSA. Cochrane Library, MEDLINE, and Embase were searched for eligible studies. A conventional and NMA was carried out to compare all therapies. Sleeping characteristics, including Apnea-Hypopnea Index (AHI), Epworth Sleepiness Scale (ESS), arterial oxygen saturation, and arousal index (AI), and changes of blood pressure were selected as outcomes...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28700102/electronic-messaging-intervention-for-management-of-cardiovascular-risk-factors-in-type-2-diabetes-mellitus-a-randomised-controlled-trial
#9
Ronghua Fang, Xuexue Deng
AIM: To determine the effectiveness of an electronic messaging support service for management of cardiovascular risk factors in diabetes patients. BACKGROUND: Micro letter and short message service are widely used, but their health education benefit for people with type 2 diabetes mellitus has not been investigated. DESIGN: Convenience sample study with randomized group assignment. METHODS: Participants completed survey questionnaires, physical and laboratory evaluations between May 2015 and May 2016, and were then randomly assigned to two groups for receipt of a Micro letter + Short message or a Phone call (control)...
July 12, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28698169/effectiveness-of-digital-medicines-to-improve-clinical-outcomes-in-patients-with-uncontrolled-hypertension-and-type-2-diabetes-prospective-open-label-cluster-randomized-pilot-clinical-trial
#10
Juan Frias, Naunihal Virdi, Praveen Raja, Yoona Kim, George Savage, Lars Osterberg
BACKGROUND: Hypertension and type 2 diabetes mellitus are major modifiable risk factors for cardiac, cerebrovascular, and kidney diseases. Reasons for poor disease control include nonadherence, lack of patient engagement, and therapeutic inertia. OBJECTIVE: The aim of this study was to assess the impact on clinic-measured blood pressure (BP) and glycated hemoglobin (HbA1c) using a digital medicine offering (DMO) that measures medication ingestion adherence, physical activity, and rest using digital medicines (medication taken with ingestible sensor), wearable sensor patches, and a mobile device app...
July 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28697259/behavioral-counseling-to-promote-a-healthful-diet-and-physical-activity-for-cardiovascular-disease-prevention-in-adults-without-known-cardiovascular-disease-risk-factors-updated-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#11
REVIEW
Carrie D Patnode, Corrine V Evans, Caitlyn A Senger, Nadia Redmond, Jennifer S Lin
Importance: Unhealthful dietary patterns, low levels of physical activity, and high sedentary time increase the risk of cardiovascular disease. Objective: To systematically review the evidence on the benefits and harms of behavioral counseling for the primary prevention of cardiovascular disease in adults without known cardiovascular risk factors to inform the US Preventive Services Task Force. Data Sources: MEDLINE, PubMed, Cochrane Central Register of Controlled Trials, and PsycINFO for studies published in the English language between January 1, 2013, and May 25, 2016, and ongoing surveillance in targeted publications through March 24, 2017...
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28693601/effects-of-the-plate-model-as-part-of-dietary-intervention-on-modification-of-selected-cardiometabolic-risk-factors-in-post-myocardial-infarction-patients-study-protocol-for-a-randomized-controlled-trial
#12
Ranil Jayawardena, Pasindu Fernando, Niroshan Lokunarangoda, Anidu Keerthi Pathirana
BACKGROUND: Cardiovascular disease remains the leading cause of morbidity and mortality worldwide, and there is a rising global burden. The effects of diet on cardiometabolic risk factors have been studied extensively. Healthy eating as a cost-effective approach to risk reduction in post-myocardial infarction patients is proven to be beneficial, and the "plate model" is one of the practical methods to achieve this objective. METHODS/DESIGN: The study will be conducted as a randomized, single-blind, controlled clinical trial for a period of 3 months...
July 10, 2017: Trials
https://www.readbyqxmd.com/read/28670117/dietary-beetroot-juice-effects-on-physical-performance-in-copd-patients-a-randomized-controlled-crossover-trial
#13
Anne Louise Friis, Carina Bjørnskov Steenholt, Anders Løkke, Mette Hansen
BACKGROUND AND OBJECTIVE: Dietary beetroot juice (BR) supplementation has been shown to reduce the oxygen (O2) consumption of standardized exercise and reduce resting blood pressure (BP) in healthy individuals. However, the physiological response of BR in chronic obstructive pulmonary disease (COPD) remains controversial. The objective was to test exercise performance in COPD, supplementing with higher doses of BR for a longer duration compared to previous trials in this patient group...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28668276/a-walking-intervention-among-men-with-prostate-cancer-a-pilot-study
#14
Claire H Pernar, Katja Fall, Jennifer R Rider, Sarah C Markt, Hans-Olov Adami, Sven-Olof Andersson, Unnur Valdimarsdottir, Ove Andrén, Lorelei A Mucci
BACKGROUND: Men diagnosed with prostate cancer have increased risk for disease progression, cardiovascular events, and impairments in quality of life. This pilot study evaluated the feasibility of a randomized walking group intervention to improve quality of life, circulating biomarkers, and morbidity among men with newly diagnosed prostate cancer. METHODS: Men were recruited at Örebro University Hospital, Sweden, and randomized to an 11-week walking group intervention (n = 21) or usual care (n = 20)...
May 31, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28666310/effectiveness-of-self-management-support-in-maintenance-haemodialysis-patients-with-hypertension-a-pilot-cluster-randomized-controlled-trial
#15
Baoyan Huang, Zheng Li, Ying Wang, Jinghua Xia, Tao Shi, Jingmei Jiang, Nolan T Marie, Xuemei Li, Sagar U Nigwekar, Limeng Chen
BACKGROUND: Uncontrolled hypertension is an independent risk factor for cardiovascular disease and is the leading cause of mortality in haemodialysis patients. The aim of this study was to examine the effectiveness of self-management support SMS) for blood pressure (BP) control and health behaviors. METHODS: We conducted a cluster randomized controlled trial (RCT) in which 90 adult haemodialysis patients were assigned to either an SMS or common intervention (CI) group...
June 30, 2017: Nephrology
https://www.readbyqxmd.com/read/28661316/effects-of-isoflavone-containing-soya-protein-on-ex-vivo-cholesterol-efflux-vascular-function-and-blood-markers-of-cvd-risk-in-adults-with-moderately-elevated-blood-pressure-a-dose-response-randomised-controlled-trial
#16
Chesney K Richter, Ann C Skulas-Ray, Jennifer A Fleming, Christina J Link, Ratna Mukherjea, Elaine S Krul, Penny M Kris-Etherton
Emerging CVD risk factors (e.g. HDL function and central haemodynamics) may account for residual CVD risk experienced by individuals who meet LDL-cholesterol and blood pressure (BP) targets. Recent evidence suggests that these emerging risk factors can be modified by polyphenol-rich interventions such as soya, but additional research is needed. This study was designed to investigate the effects of an isoflavone-containing soya protein isolate (delivering 25 and 50 g/d soya protein) on HDL function (i.e. ex vivo cholesterol efflux), macrovascular function and blood markers of CVD risk...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28659293/lower-systolic-blood-pressure-at-age-7-y-in-low-birth-weight-children-who-received-iron-supplements-in-infancy-results-from-a-randomized-controlled-trial
#17
Josefine Lindberg, Mikael Norman, Björn Westrup, Magnus Domellöf, Staffan K Berglund
Background: Low birth weight (LBW) (≤2500 g) is associated with iron deficiency in infancy and high blood pressure (BP) later in life.Objective: We investigated the effect of iron supplementation that was given to LBW infants on midchildhood BP.Design: The study was a randomized, double-blind, controlled trial that included 285 marginally LBW (2000-2500-g) infants at 2 Swedish centers between May 2004 and November 2007. The infants were randomly assigned to receive a placebo or 1 or 2 mg Fe · kg(-1) · d(-1) from 6 wk to 6 mo of age...
June 28, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28654312/effects-of-a-t-ai-chi-based-health-promotion-program-on-metabolic-syndrome-markers-health-behaviors-and-quality-of-life-in-middle-aged-male-office-workers-a-randomized-trial
#18
Ye-Sook Choi, Rhayun Song, Bon Jeong Ku
OBJECTIVES: To determine the effects of a t'ai chi-applied worksite health promotion program on metabolic syndrome markers, health behaviors, and quality of life in middle-aged male office workers at a high risk of metabolic syndrome. DESIGN: A prospective randomized controlled study. SETTING: Health center of a government office building in Korea. SUBJECTS: Forty-three male office workers with two or more metabolic syndrome markers...
June 27, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28653586/effect-of-high-protein-meal-replacement-on-weight-and-cardiometabolic-profile-in-overweight-obese-asian-indians-in-north-india
#19
Seema Gulati, Anoop Misra, Rajneesh Tiwari, Meenu Sharma, Ravindra M Pandey, Chander Prakash Yadav
The aim of the present study was to evaluate the impact of a high-protein meal replacement (HPMR) on weight and metabolic, lipid and inflammatory parameters in overweight/obese Asian Indians. In this 12-week open-label, parallel-arm randomised controlled trial, 122 overweight/obese men and women were administered either a HPMR or a control diet after 2 weeks of diet and exercise run-in. Body weight, waist circumference (WC), percentage body fat (%BF), fasting blood glucose, post-oral glucose tolerance test (post-OGTT) blood glucose, fasting and post-OGTT serum insulin, lipid profile, high-sensitivity C-reactive protein (hs-CRP), kidney function and hepatic aminotransferases were assessed before and after the intervention...
June 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28642330/effects-of-intensive-bp-control-in-ckd
#20
Alfred K Cheung, Mahboob Rahman, David M Reboussin, Timothy E Craven, Tom Greene, Paul L Kimmel, William C Cushman, Amret T Hawfield, Karen C Johnson, Cora E Lewis, Suzanne Oparil, Michael V Rocco, Kaycee M Sink, Paul K Whelton, Jackson T Wright, Jan Basile, Srinivasan Beddhu, Udayan Bhatt, Tara I Chang, Glenn M Chertow, Michel Chonchol, Barry I Freedman, William Haley, Joachim H Ix, Lois A Katz, Anthony A Killeen, Vasilios Papademetriou, Ana C Ricardo, Karen Servilla, Barry Wall, Dawn Wolfgram, Jerry Yee
The appropriate target for BP in patients with CKD and hypertension remains uncertain. We report prespecified subgroup analyses of outcomes in participants with baseline CKD in the Systolic Blood Pressure Intervention Trial. We randomly assigned participants to a systolic BP target of <120 mm Hg (intensive group; n=1330) or <140 mm Hg (standard group; n=1316). After a median follow-up of 3.3 years, the primary composite cardiovascular outcome occurred in 112 intensive group and 131 standard group CKD participants (hazard ratio [HR], 0...
June 22, 2017: Journal of the American Society of Nephrology: JASN
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