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systolic blood pressure intervention trial

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https://www.readbyqxmd.com/read/28086872/dapagliflozin-decreases-small-dense-low-density-lipoprotein-cholesterol-and-increases-high-density-lipoprotein-2-cholesterol-in-patients-with-type-2-diabetes-comparison-with-sitagliptin
#1
Toshiyuki Hayashi, Tomoyasu Fukui, Noriko Nakanishi, Saki Yamamoto, Masako Tomoyasu, Anna Osamura, Makoto Ohara, Takeshi Yamamoto, Yasuki Ito, Tsutomu Hirano
BACKGROUND: The sodium-glucose co-transporter-2 (SGLT-2) inhibitors have been reported to increase both low-density lipoprotein (LDL) and high-density lipoprotein (HDL)-cholesterol (C). This study aimed to determine how SGLT-2 inhibitors affect LDL and HDL-C subspecies. METHODS: This single center, open-label, randomized, prospective study included 80 patients with type 2 diabetes taking prescribed oral hypoglycemic agents. Patients were allocated to receive dapagliflozin (n = 40) or sitagliptin (n = 40) as add-on treatment...
January 13, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28086813/information-exchange-networks-of-health-care-providers-and-evidence-based-cardiovascular-risk-management-an-observational-study
#2
Naomi Heijmans, Jan van Lieshout, Michel Wensing
BACKGROUND: Although a wide range of preventive and clinical interventions has targeted cardiovascular risk management (CVRM), outcomes remain suboptimal. Therefore, the question is what additional determinants of CVRM and outcomes can be identified and addressed to optimize CVRM. In this study, we aimed to identify new perspectives for improving healthcare delivery and explored associations between information exchange networks of health care providers and evidence-based CVRM. METHODS: This observational study was performed parallel to a randomized clinical trial which aimed to improve professional performance of practice nurses in the Netherlands...
January 13, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28081369/randomized-controlled-ethanol-cookstove-intervention-and-blood-pressure-in-pregnant-nigerian-women
#3
Donee Alexander, Amanda Northcross, Nathaniel Wilson, Anindita Dutta, Rishi Pandya, Tope Ibigbami, Damilola Adu, John Olamijulo, Oludare Morhason-Bello, Theodore Karrison, Oladosu Ojengbede, Christopher O Olopade
RATIONALE: Hypertension during pregnancy is a leading cause of maternal mortality. Exposure to household air pollution (HAP) elevates blood pressure (BP). OBJECTIVES: Investigate ability of clean cookstove intervention to lower BP during pregnancy. METHODS: A randomized, controlled trial (RCT) was conducted in Nigeria. Pregnant women cooking with kerosene or firewood were randomly assigned to ethanol (n = 162) or control arms (n = 162). BP measurements were taken during 6 antenatal visits...
January 12, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28079300/assessing-the-accuracy-of-the-omron-hem-907xl-oscillometric-blood-pressure-measurement-device-in-patients-with-nondialytic-chronic-kidney-disease
#4
Jordana B Cohen, Tiffany C Wong, Bruce S Alpert, Raymond R Townsend
The OMRON HEM-907XL is a commercial oscillometric blood pressure (BP) monitor that was used in the Systolic Blood Pressure Intervention Trial (SPRINT), in which 28% of participants had chronic kidney disease (CKD). This study examined the accuracy of the monitor in nondialytic patients with CKD. Eighty-seven patients met inclusion criteria. The authors used a modified Association for the Advancement of Medical Instrumentation (AAMI) protocol, with one observer recording measurements from the monitor and two blinded physicians obtaining simultaneous aneroid values by auscultation...
January 12, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28075147/evaluating-the-efficacy-of-the-feeding-exercise-randomized-trial-in-overweight-and-obese-adolescents
#5
Anna Patsopoulou, Zoi Tsimtsiou, Antonios Katsioulis, Eleni Malissiova, George Rachiotis, Christos Hadjichristodoulou
BACKGROUND: The Feeding Exercise Trial in Adolescents (FETA) aimed to evaluate whether a community-based, parents-involving, combined physical activity and nutritional education program was effective in improving adiposity profiles in overweight and obese adolescents. METHODS: A total of 181 overweight and obese adolescents aged 13-15 years old were randomized in the three study groups ("Diet & Activity," "Activity," and Control). The Activity intervention included a 45-minute, 3-day per week supervised training program, while the Diet & Activity intervention included a supplementary 15 minutes of group-based sessions attended by the parents...
January 11, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28065482/efficacy-of-nutritional-recommendations-given-by-registered-dietitians-compared-to-other-healthcare-providers-in-reducing-arterial-blood-pressure-systematic-review-and-meta-analysis
#6
Glaube Raquel Riegel, Paula A B Ribeiro, Marcela Perdomo Rodrigues, Priccila Zuchinali, Leila Beltrami Moreira
INTRODUCTION: The multidisciplinary health practitioners can facilitate adherence to treatment of hypertension. Nutritional recommendations delivered by an expert in nutrition might increase the blood pressure control through a better comprehension about how nutrition plays a role on hypertension. OBJECTIVE: To evaluate the effect of nutritional intervention performed by a multidisciplinary team with and without registered dietitians compared to usual care in blood pressure control of hypertensive patients...
December 28, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28055075/oral-pharmacologic-treatment-of-type-2-diabetes-mellitus-a-clinical-practice-guideline-update-from-the-american-college-of-physicians
#7
Amir Qaseem, Michael J Barry, Linda L Humphrey, Mary Ann Forciea
Description: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on oral pharmacologic treatment of type 2 diabetes in adults. This guideline serves as an update to the 2012 ACP guideline on the same topic. This guideline is endorsed by the American Academy of Family Physicians. Methods: This guideline is based on a systematic review of randomized, controlled trials and observational studies published through December 2015 on the comparative effectiveness of oral medications for type 2 diabetes...
January 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28052877/blood-pressure-measurement-anno-2016
#8
REVIEW
Jan A Staessen, Yan Li, Azusa Hara, Kei Asayama, Eamon Dolan, Eoin O'Brien
The rational management of hypertension (HT) inevitably starts with accurate measurement of blood pressure (BP). The recently published Systolic Blood Pressure Intervention Trial implemented automated office BP measurement. However, event-driven studies have overwhelmingly indicated that out-of-the-office BP monitoring is a prerequisite for risk stratification and for identifying the need of initiating or adjusting antihypertensive drug treatment. 24-Hour ambulatory BP monitoring is the preferred method of BP measurement and addresses major issues not covered by conventional or automated office BP measurement or home BP monitoring, such as reliably diagnosing nocturnal HT (the time window of the day during which BP is most predictive of adverse cardiovascular outcome), hypotension, or masked HT, a condition that affects 15% of the general populations and carries a risk equal to that of HT on both office and out-of-the-office BP measurement...
January 4, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28050183/the-effects-of-sertraline-in-controlling-refractory-hypertension-in-women-with-premenstrual-syndrome
#9
Fatemeh Ranjbar, Fariborz Akbarzadeh, Mahboub Asadlou
Objective: The aim of this study was to evaluate the effect of Premenstrual Syndrome (PMS) treatment with selective serotonin reuptake inhibitor (SSRI) on treatment response of refractory hypertension of the patients. Method: This was a triple-blind randomized clinical trial conducted on female patients suffering from refractory hypertension and PMS at the same time. We obtained informed consent from 40 patients who had inclusion criteria and selected 20 patients for the intervention (sertraline 50 mg daily) and 20 for the control groups...
October 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28024910/the-effect-of-potassium-supplementation-on-blood-pressure-in-hypertensive-subjects-a-systematic-review-and-meta-analysis
#10
REVIEW
Tommaso Filippini, Federica Violi, Roberto D'Amico, Marco Vinceti
BACKGROUND: Several intervention studies have investigated the relation between potassium intake and blood-pressure, particularly in hypertensive subjects. However, uncertainties still exist about the existence and the amount of such an effect, and about the role of some potential effect-modifiers, including the baseline potassium intake and geographical area. METHODS: We carried out a systematic review of the evidence concerning such relation in hypertensive subjects, performing a meta-analysis and a meta-regression of RCT with selective and validated long-term (≥4weeks) potassium supplementation...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28003248/development-of-a-smartphone-enabled-hypertension-and-diabetes-mellitus-management-package-to-facilitate-evidence-based-care-delivery-in-primary-healthcare-facilities-in-india-the-mpower-heart-project
#11
Vamadevan S Ajay, Devraj Jindal, Ambuj Roy, Vidya Venugopal, Rakshit Sharma, Abha Pawar, Sanjay Kinra, Nikhil Tandon, Dorairaj Prabhakaran
BACKGROUND: The high burden of undetected and undertreated hypertension and diabetes mellitus is a major health challenge worldwide. The mPower Heart Project aimed to develop and test a feasible and scalable intervention for hypertension and diabetes mellitus by task-sharing with the use of a mobile phone-based clinical decision support system at Community Health Centers in Himachal Pradesh, India. METHODS AND RESULTS: The development of the intervention and mobile phone-based clinical decision support system was carried out using mixed methods in five Community Health Centers...
December 21, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28003201/effects-of-free-sugars-on-blood-pressure-and-lipids-a-systematic-review-and-meta-analysis-of-nutritional-isoenergetic-intervention-trials
#12
Elena Fattore, Francesca Botta, Carlo Agostoni, Cristina Bosetti
BACKGROUND: Sugar has been suggested as a central risk factor in the development of noncommunicable diseases. OBJECTIVE: We assessed the evidence of the effects of free sugars compared with complex carbohydrates on selected cardiovascular disease risk factors. DESIGN: We conducted a systematic review and meta-analysis of intervention trials to compare diets that provide a given amount of energy from free sugars with a control diet that provides the same amount of energy from complex carbohydrates...
January 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27993433/sodium-restriction-in-patients-with-ckd-a-randomized-controlled-trial-of-self-management-support
#13
Yvette Meuleman, Tiny Hoekstra, Friedo W Dekker, Gerjan Navis, Liffert Vogt, Paul J M van der Boog, Willem Jan W Bos, Gert A van Montfrans, Sandra van Dijk
BACKGROUND: To evaluate the effectiveness and sustainability of self-managed sodium restriction in patients with chronic kidney disease. STUDY DESIGN: Open randomized controlled trial. SETTING & PARTICIPANTS: Patients with moderately decreased kidney function from 4 hospitals in the Netherlands. INTERVENTION: Regular care was compared with regular care plus an intervention comprising education, motivational interviewing, coaching, and self-monitoring of blood pressure (BP) and sodium...
December 16, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27984412/impact-of-home-blood-pressure-monitoring-on-blood-pressure-control-in-older-individuals-a-french-randomized-study
#14
Christophe Tzourio, Olivier Hanon, Ophélia Godin, Aicha Soumaré, Carole Dufouil
OBJECTIVE: Home blood pressure (BP) monitoring is one of the tools recommended in hypertension management. However, its influence in older adults is seldom investigated. We aimed to assess whether regular home BP monitoring leads to a reduction of BP and an improvement in hypertension control in older adults. METHODS: In a 24-month trial, individuals aged 73-97 years were randomized in a control (office and home BP measured at 0, 12, and 24 months) or an intervention (office measured at 0, 12, and 24 months; home BP measured every 3 months) group...
December 14, 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27982160/lifestyle-intervention-on-metabolic-syndrome-and-its-impact-on-quality-of-life-a-randomized-controlled-trial
#15
Patrícia Pozas Saboya, Luiz Carlos Bodanese, Paulo Roberto Zimmermann, Andreia da Silva Gustavo, Fabricio Edler Macagnan, Ana Pandolfo Feoli, Margareth da Silva Oliveira
Background: Lifestyle intervention programs can reduce the prevalence of metabolic syndrome (MetS) and, therefore, reduce the risk for cardiac disease, one of the main public health problems nowadays. Objective: The aim of this study was to compare the effects of three types of approach for lifestyle change programs in the reduction of metabolic parameters, and to identify its impact on the quality of life (QOL) of individuals with MetS. Methods: A randomized controlled trial included 72 individuals with MetS aged 30-59 years...
December 8, 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27979046/effects-of-exercise-and-stress-management-training-on-nighttime-blood-pressure-dipping-in-patients-with-coronary-heart-disease-a-randomized-controlled-trial
#16
Andrew Sherwood, Patrick J Smith, Alan L Hinderliter, Anastasia Georgiades, James A Blumenthal
INTRODUCTION: Blunted nighttime blood pressure (BP) dipping is prognostic of cardiovascular morbidity and mortality. Patients with coronary heart disease (CHD) are often characterized by a blunted nighttime BP dipping pattern. The present study compared the effects of 2 behavioral intervention programs, aerobic exercise (EX) and stress management (SM) training, with a usual care (UC) control group on BP dipping in a sample of CHD patients. METHODS: This was a secondary analysis of a randomized, controlled trial with allocation concealment and blinded outcome assessment in 134 patients with stable CHD and exercise-induced myocardial ischemia...
January 2017: American Heart Journal
https://www.readbyqxmd.com/read/27974308/prospective-associations-between-problematic-eating-attitudes-in-midchildhood-and-the-future-onset-of-adolescent-obesity-and-high-blood-pressure
#17
Kaitlin H Wade, Michael S Kramer, Emily Oken, Nicholas J Timpson, Oleg Skugarevsky, Rita Patel, Natalia Bogdanovich, Konstantin Vilchuck, George Davey Smith, Jennifer Thompson, Richard M Martin
BACKGROUND: Clinically diagnosed eating disorders may have adverse cardiometabolic consequences, including overweight or obesity and high blood pressure. However, the link between problematic eating attitudes in early adolescence, which can lead to disordered eating behaviors, and future cardiometabolic health is, to our knowledge, unknown. OBJECTIVE: We assessed whether variations in midchildhood eating attitudes influence the future development of overweight or obesity and high blood pressure...
December 14, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27968881/a-smartphone-based-exercise-adherence-intervention-for-people-with-metabolic-syndrome-a-feasibility-pilot-study
#18
Janet Wh Sit, Sek-Ying Chair, Stanley Sc Hui, Kai-Chow Choi, Aileen Wk Chan, Eliza Ml Wong, Ho-Yu Cheng
BACKGROUND: Despite well-established benefits of exercise in the management of metabolic syndrome, evidence to support exercise adherence after program completion is lacking. We used a smartphone-based exercise adherence intervention (Virtual Trainer; Ex-VT) for adults with metabolic syndrome in Hong Kong, China. The objectives were to measure the feasibility, potential effectiveness, and implementation of Ex-VT in sustaining prescribed exercise practice for risk reduction in metabolic syndrome...
October 2016: Lancet
https://www.readbyqxmd.com/read/27965180/a-randomized-controlled-trial-of-a-community-health-worker-intervention-in-a-population-of-patients-with-multiple-chronic-diseases-study-design-and-protocol
#19
Shreya Kangovi, Nandita Mitra, Lindsey Turr, Hairong Huo, David Grande, Judith A Long
: Upstream interventions - e.g. housing programs and community health worker interventions- address socioeconomic and behavioral factors that influence health outcomes across diseases. Studying these types of interventions in clinical trials raises a methodological challenge: how should researchers measure the effect of an upstream intervention in a sample of patients with different diseases? This paper addresses this question using an illustrative protocol of a randomized controlled trial of collaborative-goal setting versus goal-setting plus community health worker support among patients multiple chronic diseases: diabetes, obesity, hypertension and tobacco dependence...
December 10, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27956676/fibrinogen-in-the-initial-resuscitation-of-severe-trauma-fiirst-a-randomized-feasibility-trial
#20
B Nascimento, J Callum, H Tien, H Peng, S Rizoli, P Karanicolas, A Alam, W Xiong, R Selby, A-M Garzon, C Colavecchia, R Howald, A Nathens, A Beckett
BACKGROUND: Decreased plasma fibrinogen concentration shortly after injury is associated with higher blood transfusion needs and mortality. In North America and the UK, cryoprecipitate transfusion is the standard-of-care for fibrinogen supplementation during acute haemorrhage, which often occurs late during trauma resuscitation. Alternatively, fibrinogen concentrate (FC) can be beneficial in trauma resuscitation. However, the feasibility of its early infusion, efficacy and safety remain undetermined...
December 2016: British Journal of Anaesthesia
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