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systolic blood pressure intervention trial

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https://www.readbyqxmd.com/read/28917372/transcendental-meditation-for-lowering-blood-pressure-an-overview-of-systematic-reviews-and-meta-analyses
#1
REVIEW
Soo Liang Ooi, Melisa Giovino, Sok Cheon Pak
BACKGROUND: Transcendental meditation (TM) is a stress reduction technique that can potentially lower blood pressure (BP) safely. The American Heart Association recommends that TM may be considered in clinical practice. OBJECTIVE: To provide an overview of all systematic reviews and meta-analyses of TM on BP for evidence-informed clinical decision making. METHOD: Systematic searches of PubMed, EBSCOhost, Cochrane Library, Web of Science, Embase, and PsycINFO for all systematic reviews and/or meta-analyses of randomized controlled trials (RCTs) with TM as an intervention, and outcome measures include systolic BP (SBP) and diastolic BP (DBP)...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28914562/the-effect-of-regular-aquatic-exercise-on-blood-pressure-a-meta-analysis-of-randomized-controlled-trials
#2
Yutaka Igarashi, Yoshie Nogami
Background No meta-analysis has examined the effect of regular aquatic exercise on blood pressure. The purpose of this study was to perform a meta-analysis to evaluate the effects of regular aquatic exercise on blood pressure. Design A meta-analysis of randomized controlled trials. Methods Databases were searched for literature published up to April 2017. The randomized controlled trials analysed involved healthy adults, an intervention group that only performed aquatic exercise and a control group that did not exercise, no other intervention, and trials indicated mean systolic blood pressure or diastolic blood pressure...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28912054/effectiveness-of-pharmacist-interventions-on-cardiovascular-risk-in-patients-with-ckd-a-subgroup-analysis-of-the-randomized-controlled-rxeach-trial
#3
Yazid N Al Hamarneh, Ross T Tsuyuki, Charlotte A Jones, Braden Manns, Marcello Tonelli, Nairne Scott-Douglass, Kailash Jindal, Wendy Tink, Brenda R Hemmelgarn
BACKGROUND: Affecting a substantial proportion of adults, chronic kidney disease (CKD) is considered a major risk factor for cardiovascular (CV) events. It has been reported that patients with CKD are underserved when it comes to CV risk reduction efforts. STUDY DESIGN: Prespecified subgroup analysis of a randomized controlled trial. SETTING & PARTICIPANTS: Adults with CKD and at least 1 uncontrolled CV risk factor were enrolled from 56 pharmacies across Alberta, Canada...
September 11, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28902880/cost-and-cost-effectiveness-of-a-school-based-education-program-to-reduce-salt-intake-in-children-and-their-families-in-china
#4
Xian Li, Stephen Jan, Lijing L Yan, Alison Hayes, Yunbo Chu, Haijun Wang, Xiangxian Feng, Wenyi Niu, Feng J He, Jun Ma, Yanbo Han, Graham A MacGregor, Yangfeng Wu
OBJECTIVE: The School-based Education Program to Reduce Salt Intake in Children and Their Families study was a cluster randomized control trial among grade five students in 28 primary schools and their families in Changzhi, China. It achieved a significant effect in lowering systolic blood pressure (SBP) in all family adults by 2.3 mmHg and in elderlies (aged > = 60 years) by 9.5 mmHg. The aim of this study was to assess the cost-effectiveness of this salt reduction program. METHODS: Costs of the intervention were assessed using an ingredients approach to identify resource use...
2017: PloS One
https://www.readbyqxmd.com/read/28902144/implementing-low-cost-community-based-exercise-programs-for-middle-aged-and-older-patients-with-type-2-diabetes-what-are-the-benefits-for-glycemic-control-and-cardiovascular-risk
#5
Romeu Mendes, Nelson Sousa, Victor Machado Reis, Jose Luis Themudo-Barata
BACKGROUND: The purpose of this study was to analyze the effects of a long-term, community-based, combined exercise program developed with low-cost exercise strategies on glycemic control and cardiovascular risk factors in middle-aged and older patients with type 2 diabetes. METHODS: Participants (n = 124; 63.25 ± 7.20 years old) engaged in either a 9-month supervised exercise program (n = 39; consisting of combined aerobic, resistance, agility/balance, and flexibility exercise; three sessions per week; 70 min per session) or a control group (n = 85) who maintained their usual care...
September 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28887862/systolic-blood-pressure-targets-diastolic-j-curve-and-cuff-artefact-in-blood-pressure-measurement-a-note-of-caution
#6
J David Spence
There is good evidence that controlling hypertension reduces the risk of stroke and other cardiovascular consequences of hypertension. The recent Systolic Blood Pressure Intervention Trial (SPRINT) trial, stopped early because of a higher risk among participants randomized to the higher blood pressure target, will no doubt lead to calls for even lower pressures. Even among participants age ≥75, those randomized to a target systolic blood pressure (SBP) < 120 mmHg had a lower risk of stroke and cardiovascular events compared with a SBP target <140 mmHg[1]...
September 8, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28887378/smoking-cessation-and-outcome-after-ischemic-stroke-or-tia
#7
Katherine A Epstein, Catherine M Viscoli, J David Spence, Lawrence H Young, Silvio E Inzucchi, Mark Gorman, Brett Gerstenhaber, Peter D Guarino, Anand Dixit, Karen L Furie, Walter N Kernan
OBJECTIVE: To assess whether smoking cessation after an ischemic stroke or TIA improves outcomes compared to continued smoking. METHODS: We conducted a prospective observational cohort study of 3,876 nondiabetic men and women enrolled in the Insulin Resistance Intervention After Stroke (IRIS) trial who were randomized to pioglitazone or placebo within 180 days of a qualifying stroke or TIA and followed up for a median of 4.8 years. A tobacco use history was obtained at baseline and updated during annual interviews...
September 8, 2017: Neurology
https://www.readbyqxmd.com/read/28887192/integrating-smartphone-technology-social-support-and-the-outdoor-physical-environment-to-improve-fitness-among-adults-at-risk-of-or-diagnosed-with-type-2-diabetes-findings-from-the-ecofit-randomized-controlled-trial
#8
Ronald C Plotnikoff, Magdalena Wilczynska, Kristen E Cohen, Jordan J Smith, David R Lubans
The risk and prevalence of Type 2 Diabetes (T2D) has dramatically increased over the past decade. The aim of this study was to develop, implement and evaluate a physical activity intervention to improve aerobic and muscular fitness among adults at risk of, or diagnosed with T2D. A 20-week, assessor blinded, parallel-group randomized controlled trial (RCT) was conducted at the University of Newcastle (June-December 2015). Adults were randomized to the intervention (n=42) or wait-list control group (n=42). The theory-based intervention included: Phase 1 (weeks 1-10) integrated group sessions (outdoor physical activity and cognitive mentoring), and the eCoFit smartphone application (app)...
September 5, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28886083/nurse-led-telephone-based-follow-up-of-secondary-prevention-after-acute-coronary-syndrome-one-year-results-from-the-randomized-controlled-nailed-acs-trial
#9
Daniel Huber, Robin Henriksson, Stina Jakobsson, Thomas Mooe
BACKGROUND: Secondary prevention after acute coronary syndrome (ACS) could reduce morbidity and mortality, but guideline targets are seldom reached. We hypothesized that nurse-led telephone-based intervention would increase adherence. METHODS: The NAILED ACS trial is a prospective, controlled, randomized trial. Patients admitted for ACS at Östersund hospital, Sweden, were randomized to usual follow-up by a general practitioner or a nurse-led intervention. The intervention comprised telephone follow-up after 1 month and then yearly with lifestyle counselling and titration of medications until reaching target values for LDL-C (<2...
2017: PloS One
https://www.readbyqxmd.com/read/28873137/association-between-more-intensive-vs-less-intensive-blood-pressure-lowering-and-risk-of-mortality-in-chronic-kidney-disease-stages-3-to-5-a-systematic-review-and-meta-analysis
#10
Rakesh Malhotra, Hoang Anh Nguyen, Oscar Benavente, Mihriye Mete, Barbara V Howard, Jonathan Mant, Michelle C Odden, Carmen A Peralta, Alfred K Cheung, Girish N Nadkarni, Ruth L Coleman, Rury R Holman, Alberto Zanchetti, Ruth Peters, Nigel Beckett, Jan A Staessen, Joachim H Ix
Importance: Trials in patients with hypertension have demonstrated that intensive blood pressure (BP) lowering reduces the risk of cardiovascular disease and all-cause mortality but may increase the risk of chronic kidney disease (CKD) incidence and progression. Whether intensive BP lowering is associated with a mortality benefit in patients with prevalent CKD remains unknown. Objectives: To conduct a systematic review and meta-analysis of randomized clinical trials (RCTs) to investigate if more intensive compared with less intensive BP control is associated with reduced mortality risk in persons with CKD stages 3 to 5...
September 5, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28869987/effects-of-intensive-systolic-blood-pressure-control-on-kidney-and-cardiovascular-outcomes-in-persons-without-kidney-disease-a-secondary-analysis-of-a-randomized-trial
#11
Srinivasan Beddhu, Michael V Rocco, Robert Toto, Timothy E Craven, Tom Greene, Udayan Bhatt, Alfred K Cheung, Debbie Cohen, Barry I Freedman, Amret T Hawfield, Anthony A Killeen, Paul L Kimmel, James Lash, Vasilios Papademetriou, Mahboob Rahman, Anjay Rastogi, Karen Servilla, Raymond R Townsend, Barry Wall, Paul K Whelton
Background: The public health significance of the reported higher incidence of chronic kidney disease (CKD) with intensive systolic blood pressure (SBP) lowering is unclear. Objective: To examine the effects of intensive SBP lowering on kidney and cardiovascular outcomes and contrast its apparent beneficial and adverse effects. Design: Subgroup analyses of SPRINT (Systolic Blood Pressure Intervention Trial). (ClinicalTrials.gov: NCT01206062)...
September 19, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28866864/the-association-between-insulin-resistance-and-atrial-fibrillation-a-cross-sectional-analysis-from-sprint-systolic-blood-pressure-intervention-trial
#12
Monique E Cho, Timothy E Craven, Alfred K Cheung, Stephen P Glasser, Mahboob Rahman, Elsayed Z Soliman, Randall S Stafford, Karen C Johnson, Jeffrey T Bates, Anna Burgner, Addison A Taylor, Leonardo Tamariz, Rocky Tang, Srinivasan Beddhu
It is unclear whether metabolic syndrome (MetS) is associated with atrial fibrillation (AF) in an older population with greater cardiovascular risk, including those with chronic kidney disease. The authors investigated the association between MetS and AF in participants in SPRINT (Systolic Blood Pressure Intervention Trial). MetS was defined based on the Modified Third National Cholesterol Education Program. The baseline prevalence rate for MetS was 55%, while 8.2% of the participants had AF. In multivariate regression analyses, AF was not associated with presence of MetS in either chronic kidney disease or non-chronic kidney disease subgroups...
September 3, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28863392/mindfulness-mediates-the-physiological-markers-of-stress-systematic-review-and-meta-analysis
#13
Michaela C Pascoe, David R Thompson, Zoe M Jenkins, Chantal F Ski
Meditation is a popular form of stress management, argued to mediate stress reactivity. However, many studies in this field commonly fail to include an active control group. Given the frequency with which people are selecting meditation as a form of self-management, it is important to validate if the practice is effective in mediating stress-reactivity using well-controlled studies. Thus, we aimed to conduct a meta-analysis investigating the neurobiological effects of meditation, including focused attention, open monitoring and automatic self-transcending subtypes, compared to an active control, on markers of stress...
August 23, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28858981/individualizing-treatment-choices-in-the-systolic-blood-pressure-intervention-trial
#14
João Pedro Ferreira, John Gregson, Kévin Duarte, François Gueyffier, Patrick Rossignol, Faiez Zannad, Stuart Pocock
BACKGROUND: Any treatment decision should be tailored to the individual patients' characteristics. A personalized approach aims to help better selecting the patients who are likely to benefit most from a treatment decision. In the systolic blood pressure intervention trial, intensive treatment reduced the rate of major cardiovascular events, but increased the rate of serious adverse events (SAEs). OBJECTIVES: To assess the trade-off between efficacy and safety to simultaneously quantify an individual patient's absolute benefit and absolute harm, helping clinicians making better therapeutic choices in daily practice...
August 30, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28854979/the-effect-of-exercise-training-on-clinical-outcomes-in-patients-with-the-metabolic-syndrome-a-systematic-review-and-meta-analysis
#15
C Ostman, N A Smart, D Morcos, A Duller, W Ridley, D Jewiss
BACKGROUND: Purpose: to establish if exercise training improves clinical outcomes in people with metabolic syndrome (MetS). Registered with PROSPERO international prospective register of systematic reviews ( https://www.crd.york.ac.uk/PROSPERO/Identifier:CRD42017055491 ). DATA SOURCES: studies were identified through a MEDLINE search strategy (1985 to Jan 12, 2017), Cochrane controlled trials registry, CINAHL and SPORTDiscus. STUDY SELECTION: prospective randomized or controlled trials of exercise training in humans with metabolic syndrome, lasting 12 weeks or more...
August 30, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28843974/acute-effects-of-video-game-playing-versus-television-viewing-on-stress-markers-and-food-intake-in-overweight-and-obese-young-men-a-randomised-controlled-trial
#16
Mario Siervo, Jason Gan, Mary S Fewtrell, Mario Cortina-Borja, Jonathan C K Wells
BACKGROUND: Sedentary or near-sedentary activities are associated with overweight/obesity in epidemiological studies. This has traditionally been attributed to physical activity displacement. A little-explored area is whether behavioural stresses alter sensations of appetite and eating behaviour. We examined whether behaviours conducted seated (television viewing, video gaming) induce different eating patterns, associated with differential levels of stress response. METHODS AND FINDINGS: We conducted a randomized controlled trial in 72 overweight/obese adult males, assigned to three groups (24 per group): (i) non-violent television (control group); (ii) non-violent game (FIFA); (iii) violent game (Call of Duty)...
August 24, 2017: Appetite
https://www.readbyqxmd.com/read/28841431/diastolic-hypotension-due-to-intensive-blood-pressure-therapy-is-it-harmful
#17
Mats Julius Stensrud, Susanne Strohmaier
BACKGROUND AND AIMS: Reducing the diastolic blood pressure (DBP) below a certain threshold may lead to inadequate organ perfusion. This raises some concerns, because pharmacotherapy reduces both systolic and diastolic pressure. We aimed to investigate whether a pathway from intensive systolic blood pressure (SBP) treatment influences cardiovascular outcomes by inducing too low DBP. METHODS: We had access to data from the Systolic Blood Pressure Intervention Trial (SPRINT) including 9361 patients with a SBP of 130 mmHg or higher and an increased cardiovascular risk...
July 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28840638/combining-walking-and-relaxation-for-stress-reduction-a-randomized-cross-over-trial-in-healthy-adults
#18
Franziska Matzer, Eva Nagele, Nikolaus Lerch, Christian Vajda, Christian Fazekas
Both physical activity and relaxation have stress-relieving potential. This study investigates their combined impact on the relaxation response while considering participants' initial stress level. In a randomized cross-over trial, 81 healthy adults completed 4 types of short-term interventions for stress reduction, each lasting for 1 hr: (1) physical activity (walking) combined with resting, (2) walking combined with balneotherapy, (3) combined resting and balneotherapy, and (4) resting only. Saliva cortisol, blood pressure, state of mood, and relaxation were measured preintervention and postintervention...
August 25, 2017: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/28834483/effect-of-intensive-blood-pressure-treatment-on-patient-reported-outcomes
#19
Dan R Berlowitz, Capri G Foy, Lewis E Kazis, Linda P Bolin, Molly B Conroy, Peter Fitzpatrick, Tanya R Gure, Paul L Kimmel, Kent Kirchner, Donald E Morisky, Jill Newman, Christine Olney, Suzanne Oparil, Nicholas M Pajewski, James Powell, Thomas Ramsey, Debra L Simmons, Joni Snyder, Mark A Supiano, Daniel E Weiner, Jeff Whittle
BACKGROUND: The previously published results of the Systolic Blood Pressure Intervention Trial showed that among participants with hypertension and an increased cardiovascular risk, but without diabetes, the rates of cardiovascular events were lower among those who were assigned to a target systolic blood pressure of less than 120 mm Hg (intensive treatment) than among those who were assigned to a target of less than 140 mm Hg (standard treatment). Whether such intensive treatment affected patient-reported outcomes was uncertain; those results from the trial are reported here...
August 24, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28834469/cost-effectiveness-of-intensive-versus-standard-blood-pressure-control
#20
Adam P Bress, Brandon K Bellows, Jordan B King, Rachel Hess, Srinivasan Beddhu, Zugui Zhang, Dan R Berlowitz, Molly B Conroy, Larry Fine, Suzanne Oparil, Donald E Morisky, Lewis E Kazis, Natalia Ruiz-Negrón, Jamie Powell, Leonardo Tamariz, Jeff Whittle, Jackson T Wright, Mark A Supiano, Alfred K Cheung, William S Weintraub, Andrew E Moran
BACKGROUND: In the Systolic Blood Pressure Intervention Trial (SPRINT), adults at high risk for cardiovascular disease who received intensive systolic blood-pressure control (target, <120 mm Hg) had significantly lower rates of death and cardiovascular disease events than did those who received standard control (target, <140 mm Hg). On the basis of these data, we wanted to determine the lifetime health benefits and health care costs associated with intensive control versus standard control...
August 24, 2017: New England Journal of Medicine
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