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https://www.readbyqxmd.com/read/29338273/adverse-drug-reactions-of-non-opioid-and-opioid-analgesics-reported-to-croatian-national-authority-from-2007-to-2014
#1
Petra Sunara, Darko Krnic, Livia Puljak
OBJECTIVE: Adverse drug reactions (ADRs) are commonly observed in the health services because of system weaknesses and individual errors. Analgesics are widely used and it can be expected that with the increased use one can expect increased number of ADRs of analgesics. The aim of this study was to analyze ADRs of non-opioid and opioid analgesics reported to the Croatian Agency for Medicinal Products and Medical Devices (HALMED) from 2007 to 2014. METHODS: HALMED provided data on generic drug name, year of the ADR report, type of report, institution, reporting person, patient's age, sex and ADR type...
November 2017: Acta Medica Academica
https://www.readbyqxmd.com/read/29335824/broad-spectrum-resistance-of-pseudomonas-aeruginosa-from-shellfish-infrequent-acquisition-of-novel-resistance-mechanisms
#2
Ana Maravić, Ivica Šamanić, Matilda Šprung, Željana Fredotović, Nada Ilić, Josipa Dragičević, Jasna Puizina
Pseudomonas aeruginosa is one the most common multidrug-resistant pathogens worldwide. It has been previously detected in marine shellfish, but its antibiotic resistance in such environment has not been explored. By combining PCR detection of acquired genes, and resistance-nodulation-cell division (RND) efflux studying, we investigated the multifactorial resistance traits of 108 P. aeruginosa isolates recovered from wild-growing Mediterranean mussels (Mytilus galloprovincialis) in Croatia. Eleven different resistance profiles were found, with the main mechanism being the overexpression of intrinsic efflux pump(s), particularly MexAB-OprM...
January 15, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29333802/an-upgraded-model-of-teaching-physical-and-rehabilitation-medicine-the-vertical-education-approach-of-split-university-croatia
#3
Tonko Vlak, Saša Moslavac, Ana Poljičanin, Jure Aljinović, Igor Barišić, Maria G Ceravolo
No abstract text is available yet for this article.
January 11, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29333148/a-pathway-to-national-guidelines-for-laboratory-diagnostics-of-chronic-kidney-disease-examples-from-diverse-european-countries
#4
Vanja Radišić Biljak, Kristin Moberg Aakre, Dogan Yucel, Anne-Sophie Bargnoux, Jean-Paul Cristol, Laurence Piéroni
The principal benefit of guidelines is to improve the quality of care received by patients. In the 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (KDIGO) was released and it is designed to provide information and assist decision making. This review gives a brief overview of a various national CKD guidelines that rely on the newly released KDIGO guidelines. All of the included countries (France, Turkey, Norway and Croatia) are non-English speaking countries and they differ in population and socio economic aspects...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29318322/persistent-organochlorine-pollutants-in-placentas-sampled-from-women-in-croatia-and-an-evaluation-of-their-dna-damaging-potential-in-vitro
#5
Davor Želježić, Snježana Herceg Romanić, Darija Klinčić, Marijana Matek Sarić, Judita Grzunov Letinić
This study investigated the levels and distribution of 17 polychlorinated biphenyls (PCBs) and organochlorine pesticides (HCB, α-HCH, β-HCH, γ-HCH, p,p'-DDE, p,p'-DDD, and p,p'-DDT) in placenta samples from women living in the coastal area of Croatia. During November 2012 to February 2013, 51 placenta samples were collected from healthy mothers. This study presents the first report about Croatian placenta samples. Each of the analysed compounds were found in all of the samples; all of the maximum values were < 1 ng g-1 w...
January 9, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29317890/enterobius-vermicularis-in-the-endometrium-of-the-uterus-a-case-report
#6
Biserka Pigac, Silvija Mašić, Valentina Mašić
Enterobius vermicularis is an intestinal nematode of humans and the most common helminth infection. Main transmission path is direct contact between infected and uninfected person meaning ingestion of the eggs. Human infections are usually asymptomatic or manifest as perianal itching. Although ectopic locations are uncommon, Enterobius can occasionally be detected in appendix, kidney, male urinary tract and female genital tract. We present a case from Varaždin General Hospital, Varaždin, Croatia in 2012, involving a 90-yr-old female patient who underwent hysterectomy leading to accidental finding of E...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29310340/the-first-case-report-of-a-large-deletion-of-the-brca1-gene-in-croatia-a-case-report
#7
Vesna Musani, Ilona Sušac, Petar Ozretić, Domagoj Eljuga, Sonja Levanat
RATIONALE: Breast cancer is one of the most common cancers in women, and it is the leading cause of cancer related deaths in Croatia. BRCA1 and BRCA2 gene mutations are the most common cause of hereditary breast cancer. PATIENT CONCERNS: In this report we describe a Croatian patient with no apparent family history of cancer, who developed breast cancer first at 29, and again at 33. DIAGNOSIS: Due to the early development of first breast cancer and triple negative status of the second, the attending physician suspected a hereditary aspect...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29288399/balkan-endemic-nephropathy-and-aristolochic-acid-i-an-investigation-into-the-role-of-soil-and-soil-organic-matter-contamination-as-a-potential-natural-exposure-pathway
#8
Alexandra T Gruia, Camelia Oprean, Alexandra Ivan, Ada Cean, Mirabela Cristea, Lavinia Draghia, Roxana Damiescu, Nikola M Pavlovic, Virgil Paunescu, Calin A Tatu
Aristolochic acids (AAs) are carcinogenic and nephrotoxic plant alkaloids present in Aristolochia species, used in traditional medicine. Recent biomolecular and environmental studies have incriminated these toxins as an etiological agent in Balkan endemic nephropathy (BEN), a severe kidney disease occurring in the Balkan Peninsula. The questions on how the susceptible populations are exposed to these toxins have not yet been clearly answered. Exposure to AAs through the food chain, and environmental pollution (soil/dust), could provide an explanation for the presence of BEN in the countries where no folkloric use of the plant has been documented (Bulgaria, Croatia)...
December 29, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29280073/first-detection-of-echinococcus-multilocularis-in-croatia
#9
Relja Beck, Željko Mihaljević, Renata Brezak, Sanja Bosnić, Ivana Lohman Janković, Peter Deplazes
Echinococcus multilocularis has been spreading through Europe but has not yet been reported in Croatia. We report the results of a surveillance programme to detect E. multilocularis in red foxes (Vulpes vulpes) in different parts of Croatia. PCR-based screening of faecal samples from 238 red foxes in 2015 and 150 in 2016 indicate prevalences of 7.5% in 2015 and 6.6% in 2016 (overall 7.2%, CI 4.9 to 10.3). Positive samples were confirmed by sequencing parts of the nad1 gene and the gene encoding mitochondrial 12S rRNA...
December 26, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29278637/medical-education-changes-students-attitudes-on-psychiatry-survey-among-medical-students-in-croatia
#10
Ana Medic Flajsman, Dunja Degmecic, Tamara Pranjkovic, Stanislav Rogulja, Dina Bošnjak, Martina Rojnic Kuzman
In Croatia, psychiatric disorders are the leading group of disorders by days of hospitalization and they are in second place according to the number of hospitalizations in the period of working age. Nevertheless, psychiatry in Croatia, as well as in the world, is one of the least attractive specialties for medical students. In this paper we determined the impact of compulsory education in psychiatry on the attitudes of medical students of the fourth year of the Zagreb school of medicine and Osijek school of medicine...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29278620/95th-anniversary-of-pathophysiology-in-croatia
#11
Zdenko Kovač
University level of Pathophysiology research and teaching in Croatia had started with the third year of Medical School of Zagreb in academic year 1919./20. Ever since, despite historical changes of the main university stake holder, the state of Croatia, Department of Pathophysiology development progressed and has made visible academic achievements, with a broader effect in medical community. The first 95 years of academic tradition and major achievements are shortly described in this paper. Professor Miroslav Mikuličić envisioned Pathophysiology in close relations with Pharmacology and made the pioneering steps of establishing the "double" department at Šalata...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29274731/simultaneous-analysis-of-opioid-analgesics-and-their-metabolites-in-municipal-wastewaters-and-river-water-by-liquid-chromatography-tandem-mass-spectrometry
#12
Ivona Krizman-Matasic, Petra Kostanjevecki, Marijan Ahel, Senka Terzic
Although published literature provides a clear demonstration of widespread occurrence of opioid analgesics (OAs) in the aquatic environment, analytical methods suitable for a systematic study of this pharmaceutical class, which would include a broad spectrum of opioid analgesics and their metabolites, are still missing. In this work, a comprehensive multiresidue method for quantitative analysis of 27 opioid analgesics and their metabolites, including 2 morphine glucuronide conjugates, was developed and validated for three matrices: raw wastewater (RW), secondary effluent (SE) and river water...
December 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29259914/ultrasound-reliability-in-detection-of-retinal-tear-in-acute-symptomatic-posterior-vitreous-detachment-with-vitreous-hemorrhage
#13
Biljana Kuzmanović Elabjer, Mladen Bušić, Ana Bišćan Tvrdi, Daliborka Miletić, Damir Bosnar, Mirjana Bjeloš
Cross-sectional study of 75 consecutive patients presenting with acute symptomatic posterior vitreous detachment (ASPVD) and vitreous hemorrhage was conducted at University Eye Clinic, University Hospital "Sveti Duh", Zagreb, Croatia. To check ultrasound reliability in detecting retinal tears in patients with ASPVD, transpalpebral ultrasound of the eye and the orbit was performed followed by fundus examination initially and in 6wk period. In 13 (17%) patients membranous lesion with ultrasound characteristics of retinal tear was detected...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29251431/the-10th-joint-meeting-on-medicinal-chemistry-jmmc%C3%A2-2017-held-in-dubrovnik-croatia
#14
Ivana Perković, Višnja Stepanić, Vesna Gabelica Marković
The Croatian Chemical Society was established in 1926 and has developed over the decades into a society that actively supports all chemical activities in Croatia. The Society has eight divisions, the youngest of which, the Division of Medicinal and Pharmaceutical Chemistry, was established in 2012 and immediately became a member of the European Federation of Medicinal Chemistry (EFMC). The mission of the Medicinal and Pharmaceutical Chemistry Division is the promotion and development of scientific, professional, and educational activities within the medicinal chemistry community in Croatia, as well as to build partnerships and collaborations with other primarily EU-based medicinal chemistry societies...
December 18, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29245492/european-species-of-the-aphid-genus-i-eulachnus-i-del-guercio-1909%C3%A2-hemiptera-aphididae-lachninae-revision-and-molecular-phylogeny
#15
Mariusz Kanturski, Łukasz Kajtoch, Karina Wieczorek
The aphid genus Eulachnus in Europe is revised to include 12 species, using an integrative taxonomy approach, based on morphometric, molecular and biological traits. Fundatrix, apterous and alate viviparous female of a new species-Eulachnus stekolshchikovi Kanturski sp. nov. are described. Neotypes are designated for E. agilis, E. brevipilosus and E. nigricola. Lectotypes are designated for E. alticola, E. cembrae, E. rileyi and E. tuberculostemmatus. New synonyms are proposed: E. abameleki syn. nov. (= Cinara pini), E...
November 27, 2017: Zootaxa
https://www.readbyqxmd.com/read/29240028/genotype-phenotype-correlation-of-%C3%AE-thalassemia-in-croatian-patients-a-specific-hbb-gene-mutations
#16
Jerko Vucak, Daniel Turudic, Danko Milosevic, Marko Bilic, Zrinko Salek, Martina Rincic, Ernest Bilic
An analysis of genotype-phenotype correlation was performed for 14 patients with beta-thalassemia who had been registered in Referral Centre for hematology and oncology of the University Hospital Centre, Zagreb, Croatia. HBB gene mutations were determined using a gene-specific Q5 High-Fidelity PCR analysis with direct DNA sequencing of amplified transcripts. Mahidol score index used for classification of thalassemia severity was found to be low for all the patients enrolled in the study, indicating a mild β-thalassemia phenotype with no signs of disease progression...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29230529/sexual-maturity-and-life-stage-influences-toxic-metal-accumulation-in-croatian-brown-bears
#17
Maja Lazarus, Ankica Sekovanić, Tatjana Orct, Slaven Reljić, Jasna Jurasović, Đuro Huber
The influence of reproductive and (early) life stages on toxic metal levels was investigated in the brown bear (Ursus arctos), the largest mammalian predator species in Croatia. The purpose was to examine critical clusters in a population that might be at a higher risk of adverse health effects caused by metals as environmental contaminants. Levels of cadmium, mercury and lead in muscle, liver and kidney cortex of 325 male and 139 female bears, quantified by inductively coupled plasma mass spectrometry, were analysed according to distinct bear life stages (young: cub, yearling, subadult; mature: adult)...
December 12, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29227999/ancient-connections-among-the-european-rivers-and-watersheds-revealed-from-the-evolutionary-history-of-the-genus-telestes-actinopterygii-cypriniformes
#18
Ivana Buj, Zoran Marčić, Marko Ćaleta, Radek Šanda, Matthias F Geiger, Jörg Freyhof, Annie Machordom, Jasna Vukić
In order to better understand the complex geologic history of the Mediterranean area, we have analysed evolutionary history, phylogeographic structure and molecular diversity of freshwater fishes belonging to the genus Telestes. As primary freshwater fishes distributed largely in the Mediterranean basin, this genus represents a suitable model system for investigating the historical biogeography of freshwater drainage systems in southern Europe. In this investigation we have included samples representing all Telestes species and based our analyses on one mitochondrial and one nuclear gene...
2017: PloS One
https://www.readbyqxmd.com/read/29225816/complement-dependent-cytotoxicity-and-luminex-technology-for-human-leucocyte-antigen-antibody-detection-in-kidney-transplant-candidates-exposed-to-different-sensitizing-events
#19
Nataša Katalinić, Alma Starčević, Martina Mavrinac, Sanja Balen
Background: The aim of this study was to determine the frequency of exposure to different sensitizing events (SEs) and to assess their effects on human leucocyte antigen (HLA) alloimmunization in transplant candidates using two different HLA antibody screening techniques: complement-dependent cytotoxicity (CDC) and Luminex. Methods: This retrospective study included HLA antibody screening results for 163 patients on the kidney transplant waiting list (WL) tested from March 2012 until the end of December 2015 at the Tissue Typing Laboratory, Rijeka, Croatia...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29217468/availability-of-hepatitis-c-diagnostics-and-therapeutics-in-european-and-eurasia-countries
#20
Hakan Leblebicioglu, Joop E Arends, Resat Ozaras, Giampaolo Corti, Lurdes Santos, Christoph Boesecke, Andrew Ustianowski, Ann-Sofi Duberg, Simona Ruta, Nermin N Salkic, Petr Husa, Ivana Lazarevic, Juan A Pineda, Natalia Yurievna Pshenichnaya, Tengiz Tsertswadze, Mojca Matičič, Edmond Puca, Gulzhan Abuova, Judit Gervain, Ramin Bayramli, Salih Ahmeti, Mairi Koulentaki, Badreddine Kilani, Adriana Vince, Francesco Negro, Mustafa Sunbul, Dominique Salmon
BACKGROUND: Treatment with direct acting antiviral agents (DAAs) has provided sustained virological response rates in >95% of patients with chronic hepatitis C virus (HCV) infection. However treatment is costly and market access, reimbursement and governmental restrictions differ among countries. We aimed to analyze these differences among European and Eurasian countries. METHODS: A survey including 20-item questionnaire was sent to experts in viral hepatitis...
December 4, 2017: Antiviral Research
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