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Barbara Jenko, Matija Tomšič, Biljana Jekić, Vera Milić, Vita Dolžan, Sonja Praprotnik
Objectives: Methotrexate (MTX) is the first line treatment for rheumatoid arthritis (RA), but nevertheless 30% of patients experience MTX inefficacy. Our aim was to develop a clinical pharmacogenetic model to predict which RA patients will not respond to MTX monotherapy. We also assessed whether this model can be generalized to other populations by validating it on a group of Serbian RA patients. Methods: In 110 RA Slovenian patients, data on clinical factors and 34 polymorphisms in MTX pathway were analyzed by Least Absolute Shrinkage and Selection Operator (LASSO) penalized regression to select variables associated with the disease activity as measured by Disease Activity Score (DAS28) score after 6 months of MTX monotherapy...
2018: Frontiers in Pharmacology
Mirjana Novkovic, Dragan Matic, Jelena Kusic-Tisma, Nebojsa Antonijevic, Dragica Radojkovic, Ljiljana Rakicevic
The correct Author names are shown in this paper.
February 5, 2018: European Journal of Clinical Pharmacology
Shamil D Cooray, Neel M Heerasing, Laura A Selkrig, V Nathan Subramaniam, P Shane Hamblin, Cameron J McDonald, Catriona A McLean, Elissa McNamara, Angeline S Leet, Stuart K Roberts
BACKGROUND: Juvenile hemochromatosis is the most severe form of iron overloading phenotype. Although rare, it should be suspected in patients who present with hypogonadotropic hypogonadism, diabetes mellitus, or cardiomyopathy without a clear cause. CASE PRESENTATION: A young Serbian male presenting with end-stage heart failure was referred for extracorporeal membrane oxygenation. An endomyocardial biopsy revealed cytoplasmic iron deposits in myocytes. His condition was stabilized with biventricular assist devices and he was listed for heart transplantation...
January 26, 2018: Journal of Medical Case Reports
Ivan Pavlovic, Snezana Pejic, Sofija Glumac, Ana Todorovic, Vesna Stojiljkovic, Natasa Popovic, Ljubica Gavrilovic, Snezana B Pajovic, Sanja Radojevic-Skodric, Zoran Dzamic, Gordana Basta-Jovanovic
PURPOSE: Indications of kidney cancer outcome in lowerincome countries are based on an incidence/mortality ratio due to lack of survival information. This study was conducted to provide outcome data in Serbian patients with renal cell carcinoma (RCC) and to identify prognostic factors that could affect their overall survival (OS). METHODS: This retrospective study included 185 patients who underwent nephrectomy. We assessed certain clinicopathological data including age, gender, tumor size, grade, stage and histological subtypes for their possible impact on OS...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
J Jankovic, M Mirkovic, A Jovic-Vranes, M Santric-Milicevic, Z Terzic-Supic
OBJECTIVE: The objective was to analyze possible inequalities by gender in the utilization of health services (general practitioner [GP] and hospital), among people with non-communicable diseases (NCDs) in the Republic of Serbia, with special reference to multimorbidity. In addition, we examined the prevalence patterns of NCDs by sociodemographic characteristics of the population. STUDY DESIGN: This study is a population-based, cross-sectional survey. METHODS: A secondary analysis from the 2013 Serbian National Health Survey included 13,765 adults aged ≥20 years...
January 4, 2018: Public Health
Kristefer Stojanovski, Alaka Holla, Ilir Hoxha, Elizabeth Howell, Teresa Janevic
The conflict in Kosovo created mass displacement and a fractured health system. Roma, Ashkali, and Balkan Egyptian communities are particularly vulnerable to discrimination and exclusion from institutions. We aimed to examine Roma, Ashkali, and Balkan Egyptian disparities in quantity and quality of antenatal care received. We conducted a cross-sectional study in August 2012 with 603 women aged 15 or older who had given birth in the previous two years. We measured quantity of antenatal care using number of visits and quality of care using antenatal checklists...
December 2017: Health and Human Rights
L Stojanovich, A Djokovic, N Stanisavljevic, M Zdravkovic
Objectives To investigate a possible relationship between cerebrovascular, such as stroke and transient ischaemic attack, and various cutaneous manifestations (livedo reticularis, skin ulcerations, pseudovasculitis lesions, superficial cutaneous necrosis and digital gangrene) in antiphospholipid syndrome (APS). This report is based on a Serbian cohort of APS patients. Methods A total of 508 antiphospholipid syndrome APS patients were assessed: 360 with primary (PAPS) and 148 with APS associated with SLE (SAPS)...
January 1, 2018: Lupus
Miodrag Stojanović, Dijana Stojanović, Nataša Rančić, Aleksandra Ignjatović, Zorica Antic, Snezana Miljkovic, Tatjana Rajovic
INTRODUCTION: Thyroid cancer (TC) is the most common malignant disease of the endocrine system. The incidence of the TC has been increasing worldwide, especially in female population. However, mortality from TC is low in both males and females. The objective of the paper was to determine and to analyze incidence and mortality trends of TC in males and females in the central Serbia in the period 1999-2014. METHOD: In this descriptive study data from the Serbian Cancer Registry were used...
October 2017: Annali Dell'Istituto Superiore di Sanità
Bojana Vasilijević, Jelena Knežević-Vukčević, Dragana Mitić-Ćulafić, Dejan Orčić, Marina Francišković, Tatjana Srdic-Rajic, Marina Jovanović, Biljana Nikolić
Chemical composition and antioxidative, genotoxic and cytotoxic potential of essential oil (EO) and post-distillation waste (PDW) of Serbian Juniperus communis L. var. saxatilis Pall. was studied in human lung carcinoma (A549) and normal lung fibroblast (MRC-5) cells. GC-MS analysis identified 93.95% of total EO content and determined α-pinen as a dominant component (23.61%). LC-MS/MS analysis of PDW pointed at rutin (12.2 mg g-1) and quinic acid (11.1 mg g-1) as the most abundant. Antioxidativity of PDW was strong in DPPH (IC50 was 5...
December 26, 2017: Food and Chemical Toxicology
Ljilja Torović
This paper presents data on the occurrence of Fusarium toxins - zearalenone, deoxynivalenol and fumonisins B1 and B2 - in corn flours and corn flakes marketed in Serbia. A total of 71 sample was collected over 2013-2016 and analysed using HPLC with UV or fluorescence detection. In case of corn flours, none of the samples taken in 2013 exhibited presence of ZEA or DON, whereas 90% were positive for FUMs. In 2015, occurence was very high: ZEA 93%, DON 86% and FUMs 100% (mean 43.3, 322.6 and 323.0 μg kg-1, respectively), with 21% of the samples exceeding the maximum level for ZEA and 7% for DON and FUMs...
December 26, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Ljilja Torović, Nina Dimitrov, André Lopes, Carla Martins, Paula Alvito, Ricardo Assunção
This paper reports the first study of patulin occurrence in fruit juices and risk assessment related to patulin intake by children, adolescents and adults in Serbia. During three consecutive years (2013-2015), 142 fruit (apple or multi-fruit) juices were collected from the market and analysed using HPLC-UV. Patulin was found in 51.4% of juices with 0.7% of the samples in excess of the legal limit of 50 μg kg-1 (mean 4.3 μg kg-1). Apple juices showed significantly higher percentage of contaminated samples (74...
December 26, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Novkovic Mirjana, Matic Dragan, Kusic-Tisma Jelena, Antonijevic Nebojsa, Radojkovic Dragica, Rakicevic Ljiljana
PURPOSE: Bleeding is one of the possible adverse events during clopidogrel therapy. The CYP2C19 gene is the most significant genetic factor which influences response to clopidogrel treatment. We aimed to examine the contribution of the CYP2C19 gene to bleeding occurrence during clopidogrel therapy in Serbian patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). METHODS: This case-control study included 53 patients who experienced bleeding and 55 patients without bleeding...
December 19, 2017: European Journal of Clinical Pharmacology
Goran Stevanovic, Lidija Lavadinovic, Svetlana Filipovic Vignjevic, Renée Holt, Katarina Ilic, Francesco Berlanda Scorza, Erin Sparrow, Vera Stoiljkovic, Guido Torelli, Tamra Madenwald, Muriel Socquet, Aleksandra Barac, Yordanka Ilieva-Borisova, Mijomir Pelemis, Jorge Flores
This study was a phase I double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a Serbian-produced seasonal trivalent split, inactivated influenza vaccine in healthy adults. The vaccine was manufactured in eggs by the Torlak Institute of Virology, Vaccines and Sera, Belgrade, Serbia and contained A/H1N1, A/H3N2 and B viruses. The clinical trial took place at the Clinical Center of Serbia in Belgrade. Sixty healthy volunteers, aged 18-45 years, were enrolled in the trial...
December 14, 2017: Human Vaccines & Immunotherapeutics
Visnja Djordjic, Jagoda Jorga, Snezana Radisavljevic, Ivana Milanovic, Predrag Bozic, Sergej M Ostojic
OBJECTIVE: Thinness is rarely highlighted or regularly monitored among children in developed countries although it may be rather frequent and pose a significant risk to children's health. We aimed to describe the prevalence of mild, moderate and severe thinness among young Serbian schoolchildren. DESIGN: Cross-sectional study of schoolchildren aged 6-9 years. Children were assessed for weight, height and BMI as part of the WHO European Childhood Obesity Surveillance Initiative in Serbia...
December 13, 2017: Public Health Nutrition
Ljiljana Mihić, Zdenka Novović, Milica Lazić, David J A Dozois, Radomir Belopavlović
The Ruminative Thought Scale (RTS) was developed to measure the ruminative thinking style, presumably common to various psychopathological disorders. However, prior factor-analytic research was inconclusive regarding unidimensionality versus multidimensionality of the RTS. The present study was conducted on a large, heterogeneous Serbian sample ( N = 838). A subsample was retested 6 months later providing information about symptoms of depression and various anxiety symptoms. Results showed that a bifactor model of the RTS (representing one general and four group factors) had a better fit than the second-order and one-factor models...
February 1, 2017: Assessment
Marko Jovic, Marcos Sforza, Milan Jovanovic, Marija Jovic
We examined the validity of the Serbian version of the Acceptance of Cosmetic Surgery Scale (ACSS; Henderson-King and Henderson-King 2005). A total of 622 Serbian adults completed the ACSS, along with Serbian translations of measures for the discrepancy between actual body weight and ideal body weight, body appreciation, sociocultural attitudes toward appearance, and demographics. Confirmatory factor analyses were conducted to compare how different ACSS models fitted the collected data. A three-factor model provided the best fit to the data relative to two- and one-factor models...
2017: Current Psychology
Milica Pantelić, Dragana Dabić Zagorac, Uroš Gašić, Sonja Jović, Zoran Bešlić, Slavica Todić, Maja Natić
Phenolic profiles of young monovarietal white and red wines from the Central Serbia were investigated. Quantification of phenolics was done using ultra-high-performance liquid chromatography (UHPLC) coupled with a diode array detector and a triple-quadrupole mass spectrometer. Generally, red wines were characterised with higher phenolics content when compared to the white wines. This applies also for the total phenolics content (TPC) and radical scavenging activity (RSA) values. Among all the samples, the red wine from autochthonous Serbian variety 'Prokupac' stood out with unique composition, showing the highest TPC, RSA and the highest concentration of the individual phenolics...
November 26, 2017: Natural Product Research
Katarina M Vučićević, Branislava R Miljković, Bojana C Golubović, Marija N Jovanović, Sandra D Vezmar Kovačević, Milica D Ćulafić, Milena M Kovačević, Johan J de Gier
BACKGROUND: During the initiation of treatment of a chronic disease, patients may have varying interests, expectations, concerns, and reasons to stop treatment, influencing compliance with prescribed treatment. Thus, healthcare professionals are expected to integrate these needs into medicines management. OBJECTIVES: To determine what information is important to patients; assess predictors of patients' interests, expectations, concerns, reasons to stop therapy; evaluate drug-related problems following initiation of therapy and summarize how pharmacists resolve them during patient-pharmacist counselling...
November 22, 2017: European Journal of General Practice
Nemanja Rancic, Neven Vavic, Katarina Obrencevic, Filip Pilipovic, Viktorija Dragojevic-Simic
Background: Increasing immunosuppressant consumption and expenditure is a quite a challenge in transplantation medicine. The aim of the study was to characterize the utilization and expenditure of tacrolimus, backbone, and standard of care in immunosuppression regimen in Serbian solid organ transplant recipients. Methods: This study was performed as retrospective cross-sectional study during a 3-year period (from 2013 to 2015) in Serbia. The Anatomical Therapeutic Chemical Classification/Defined Daily Doses (ATC/DDD) international system was used for consumption evaluation...
2017: Frontiers in Public Health
Clare J Phythian, Siobhan Mullan, Andrew Butterworth, Sarah Lambton, Jelena Ilić, Jelena Burazerović, Elvir Burazerović, Katharine A Leach
The selection and field application of animal-based welfare measures for pigs, sheep, dairy cows and broilers was the first step towards the future development of welfare improvement schemes for Serbia - a country that is applying for EU accession. The aim of this pilot study was to: (1) test the feasibility of a protocol for monitoring farm animal welfare in Serbia, (2) ascertain preliminary data on animal-based outcomes of farm welfare and (3) gain insight into Serbian farmers' understanding of animal welfare as part of a wider project working towards inclusion of animal-based assessments in a 'higher welfare' voluntary assurance scheme...
November 2017: Veterinary Medicine and Science
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