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Snežana Mugoša, Nataša Djordjević, Nina Djukanović, Dragana Protić, Zoran Bukumirić, Ivan Radosavljević, Aneta Bošković, Zoran Todorović
The aim of the present study was to undertake a study on the prevalence of cytochrome P450 2D6 (CYP2D6) poor metabolizer alleles (*3, *4, *5, and *6) on a Montenegrin population and its impact on developing adverse drug reactions (ADRs) of β-blockers in a hospitalized cardiac patient population. A prospective study was conducted in the Cardiology Center of the Clinical Center of Montenegro and included 138 patients who had received any β-blocker in their therapy. ADRs were collected using a specially designed questionnaire, based on the symptom list and any signs that could point to eventual ADRs...
2016: Patient Preference and Adherence
Annelies Kerckhof, Velibor Spalevic, Veerle Van Eetvelde, Jan Nyssen
Land use changes have been investigated in the surroundings of 14 rural Montenegrin settlements in order to get specific information about trends in land abandonment since around 1950. Permanently, seasonally and less inhabited settlements with different geographic conditions were studied. This was done by interviewing local inhabitants, which enabled a holistic approach to reveal the underlying processes of land abandonment. According to the observed patterns of land use change, the study sites can be categorized into intensified, urbanized, extensified, overgrown and forested cases...
2016: SpringerPlus
Boban Mugosa, Danijela Vujosevic, Massimo Ciccozzi, Maria Beatrice Valli, Maria Rosaria Capobianchi, Alessandra Lo Presti, Eleonora Cella, Marta Giovanetti, Alessia Lai, Silvia Angeletti, Fabio Scarpa, Dragica Terzić, Zoran Vratnica
In 2009 an influenza A epidemic caused by a swine origin H1N1strain, unusual in human hosts, has been described. The present research is aimed to perform the first phylogenetic investigation on the influenza virus A (H1N1) strains circulating in Montenegro, from December 1, 2009, when the first case of death due to H1N1 was confirmed, and the epidemic began causing a total of four fatalities. The phylogenetic analysis of the strains circulating showed the absence of a pure Montenegrin cluster, suggesting the occurrence of multiple re-introductions in that population from different areas till as far as the early 2010...
November 2016: Journal of Medical Virology
Olivera Miljanović, Bojana Cikota-Aleksić, Dragan Likić, Danilo Vojvodić, Ognjen Jovićević, Zvonko Magić
UNLABELLED: In order to assess the association between gene polymorphisms and otitis media (OM) proneness, tumor necrosis factor alpha (TNFA) -308, interleukin (IL) 10-1082 and -3575, IL6 -597, IL2 -330, and CD14 -159 genotyping was performed in 58 OM-prone children and 85 controls who were exposed to similar number and frequency of environmental and host risk factors. The frequencies of genotypes (wild type vs. genotypes containing at least one polymorphic allele) were not significantly different between groups, except for IL10 -1082...
June 2016: European Journal of Pediatrics
Milica Martinovic, Goran Belojevic, Gary W Evans, Dragan Lausevic, Bogdan Asanin, Mira Samardzic, Natasa Terzic, Snezana Pantovic, Marina Jaksic, Jelena Boljevic
BACKGROUND: Newly emerging Western style economic systems provide new opportunities to study the prevalence and predictors of childhood obesity. We also provide for the first time a national study of childhood obesity using all three international anthropometric criteria. METHODS: The sample included 4097 Montenegrin children, 2076 boys (50.7%) and 2021 girls. Anthropometric measurements were performed in school. The questionnaire for parents included questions on 24 potential contributing factors for childhood obesity...
October 2015: European Journal of Public Health
M Kecmanović, N Jović, M Keckarević-Marković, D Keckarević, G Stevanović, P Ignjatović, S Romac
Lafora disease (LD) is an autosomal recessive, progressive disorder characterized by myoclonus and seizures, inexorable neurologic deterioration, cognitive decline and poor prognosis. LD is caused by mutations either in the EPM2A or in NHLRC1 genes. Here we report clinical and genetic findings on 14 LD patients from 10 families of Serbian/Montenegrin origin. Molecular diagnostics was performed by sequencing the coding regions of the EPM2A and NHLRC1 genes. In addition, haplotype analysis of the chromosomes carrying the two most frequent mutations (c...
January 2016: Clinical Genetics
Slavka Stanković, Mihajlo Jović, Bojan Tanaskovski, Marija L Mihajlović, Danijela Joksimović, Lato Pezo
To assess metal pollution, Fe, Mn, Cu, Zn, Pb, Ni, Co, As, Cd, and Hg contents in samples of the seagrass Posidonia oceanica and surface sediment, collected at eight locations along the Montenegrin coast, were determined. The metal pollution index (MPI) and metal enrichment factor (EF) were then calculated. MPI and EF were lower in sediment than in P. oceanica at the same locations. This was very evident for EF values of Hg and Cd. Based on the Pearson's correlations and EF values, it was possible to conclude that the last two metals' content in the seagrass did not originate from the crustal sources or natural weathering processes...
June 2015: Environmental Science and Pollution Research International
Ljiljana Cvejanov-Kezunović, Jadranka Mustajbegović, Milan Milosevic, Rok Civljak
This cross-sectional study was performed in nine Montenegrin hospitals to estimate the burden of occupational exposure to blood among hospital workers in Montenegro in 2010 using a modified Croatian self-reporting questionnaire on exposure to blood-borne infections. Of the 1043 respondents, 517 (49.6 %) reported exposure to blood. Variations between the hospitals were not significant, except for the hospital in Kotor, which stands out with the high percentage of exposed hospital workers (p<0.05). More than 77 % of exposures were not reported through standard hospital protocols at the time of the incident...
September 2014: Arhiv za Higijenu Rada i Toksikologiju
Lejla Kovacevic, Kristiina Tambets, Anne-Mai Ilumäe, Alena Kushniarevich, Bayazit Yunusbayev, Anu Solnik, Tamer Bego, Dragan Primorac, Vedrana Skaro, Andreja Leskovac, Zlatko Jakovski, Katja Drobnic, Helle-Viivi Tolk, Sandra Kovacevic, Pavao Rudan, Ene Metspalu, Damir Marjanovic
Contemporary inhabitants of the Balkan Peninsula belong to several ethnic groups of diverse cultural background. In this study, three ethnic groups from Bosnia and Herzegovina - Bosniacs, Bosnian Croats and Bosnian Serbs - as well as the populations of Serbians, Croatians, Macedonians from the former Yugoslav Republic of Macedonia, Montenegrins and Kosovars have been characterized for the genetic variation of 660 000 genome-wide autosomal single nucleotide polymorphisms and for haploid markers. New autosomal data of the 70 individuals together with previously published data of 20 individuals from the populations of the Western Balkan region in a context of 695 samples of global range have been analysed...
2014: PloS One
Mihajlo Jović, Slavka Stanković
Considering the growing concern due to different levels of anthropogenic loadings, the main purpose of this study was to identify the levels of trace metals (Fe, Mn, Cu, Zn, Co, Ni, Cd, Pb and Hg) in the mussels Mytilus galloprovincialis sampled along the marine coast of Boka Kotorska Bay, Montenegro. In comparison with the permissible limits set by the EU and the US FDA, all trace metal concentrations found in the mussels from the coastal area of Boka Kotorska Bay were lower than the prescribed limits. Generally, the trace metal concentrations found in Montenegrin mussels are within the range of trace metal concentrations determined in low to moderately polluted Adriatic areas...
August 2014: Food and Chemical Toxicology
Serkan Dogan, Lejla Kovacević, Damir Marjanović
Allele frequencies of 15 STRs included in the PowerPlex 16 System (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX and FGA) were calculated from the referent sample of 100 unrelated individuals of both sexes from Turkish student population living in Sarajevo, Bosnia and Herzegovina. Buccal swab, as a source of DNA, was collected from the volunteers from whom the informed consent form was obtained. DNA extraction was performed using QIAamp DNA Micro kit by Qiagen...
December 2013: Collegium Antropologicum
Milica Martinovic, Goran Belojevic, Gary W Evans, Bogdan Asanin, Dragan Lausevic, Natasa Duborija Kovacevic, Mira Samardzic, Marina Jaksic, Snezana Pantovic
BACKGROUND: Health inequalities may begin during childhood. The aim of this study was to investigate the main effect of poverty and its interactive effect with gender on children's blood pressure. METHODS: The study was performed in two elementary schools from a rural region near Podgorica, the capital of Montenegro. A questionnaire including questions on family monthly income, children's physical activity and the consumption of junk food was self-administered by parents of 434 children (223 boys and 211 girls) aged 6-13 years...
June 2014: European Journal of Public Health
Gianguglielmo Zehender, Chiara Sorrentino, Alessia Lai, Erika Ebranati, Elena Gabanelli, Alessandra Lo Presti, Danijela Vujoševic, Dragan Lauševic, Dragica Terzić, Renata Shkjezi, Silvia Bino, Zoran Vratnica, Boban Mugosa, Massimo Galli, Massimo Ciccozzi
More than 20 million hepatitis C virus (HCV) carriers live in the countries of the Eastern Mediterranean. We determined HCV genotype distribution among chronically infected patients in Montenegro and investigated the phylodynamics and phylogeography of the most represented HCV subtypes. The HCV-NS5b sequences of the Montenegrin patients were compared with sequences isolated in different known localities of the Mediterranean area, Europe and Asia. A Bayesian approach was used in order to allow the simultaneous estimate of the evolutionary rate, time-scaled phylogeny, demography and ancestral spatial status...
July 2013: Infection, Genetics and Evolution
Danijela Vujosević, Vineta Vuksanović, Mario Poljak, Nebojsa Jokmanović
The risk of high-grade lesions and carcinoma is known to correlate with specific high-risk HPV genotypes. The distribution of HPV types varies between countries and little is known about HPV distribution in our country. Therefore, the purpose of this study was to determine the range and frequency of HPV genotypes in studied group of women in Montenegro. HPV genotypes were determined using the method of enzyme restriction of PCR products amplified with group-specific primers MY09/MY11 and restricted with seven different restriction endonucleases...
2012: Acta Medica (Hradec Králové)
Danijela Joksimovic, Ilija Tomic, Ana R Stankovic, Mihajlo Jovic, Slavka Stankovic
The concentrations of trace metals (Fe, Zn, Mn, Ni, Cu, Co and Cr) were determined for the first time in Mediterranean blue mussels (Mytilus galloprovincialis) and surface sediments. The mussel and sediment samples were collected from five sites on the Montenegrin coastal area (southeastern Adriatic Sea) in the fall of 2005 and 2006. The collected samples were digested with a microwave digestion system. The maximum Fe, Zn, Mn, Ni, Cu, Co and Cr mean concentrations in the mussel samples were 603.0, 345.0, 85...
July 15, 2011: Food Chemistry
Natasha Duborija-Kovacevic, Milica Martinovic
BACKGROUND: This study is aimed at evaluating the pharmacotherapy of obstructive airway diseases (OAD) in the Montenegrin outpatient care (MOC) in 2010. METHODS: Data on the reimbursed drugs which were prescribed during the reference period were obtained from the National Database that was established within the Health Insurance Fund of Montenegro in 2004. We have applied the standard pharmacoepidemiologic methodology with the defined daily dose (DDD) along with the Anatomical Therapeutic Chemical (ATC) classification of drugs...
2012: Multidisciplinary Respiratory Medicine
Behxhet Mustafa, Avni Hajdari, Feriz Krasniqi, Esat Hoxha, Hatixhe Ademi, Cassandra L Quave, Andrea Pieroni
BACKGROUND: Ethnobotanical studies are crucial in South-Eastern Europe for fostering local development and also for investigating the dynamics of Traditional Environmental Knowledge (TEK) related to plants in one of the most crucial European hotspots for biocultural diversity. The current medico-ethnobotanical survey was conducted in rural alpine communities in Kosovo. The aims of the study were twofold: 1) to document the state of TEK of medicinal plants in these communities; 2) to compare these findings with that of similar field studies previously conducted among local populations inhabiting the Montenegrin and Albanian side of the same Alpine range...
2012: Journal of Ethnobiology and Ethnomedicine
G Zivanovic, C Arenas, F Mestres
Lethal chromosomal frequencies were obtained from three Drosophila subobscura samples from the Mt. Avala (Serbia) population in September 2003 (0.218), June 2004 (0.204) and September 2004 (0.250). These values and those from other Balkan populations studied previously (Petnica, Kamariste, Zanjic and Djerdap) were used to analyze the possible effect of population, year, month and altitude above sea level on lethal chromosomal frequencies. According to ANOVAS no effect were observed. Furthermore, the lethal frequencies of the Balkan populations did not vary according to latitude...
October 2011: Genetika
I Stanković, A Bulajić, A Vučurović, D Ristić, K Milojević, J Berenji, B Krstić
In a four-year survey to determine the presence and distribution of viruses in tobacco crops at 17 localities of the Vojvodina Province and Central Serbia, 380 samples were collected and analyzed by DAS-ELISA. Out of the seven viruses tested, tomato spotted wilt virus (TSWV), potato virus Y (PVY), tobacco mosaic virus (TMV), cucumber mosaic virus (CMV), and alfalfa mosaic virus (AMV) were detected in 37.9, 33.4, 28.7, 23.9, and 15.5% of the total tested samples, respectively. TSWV was the most frequently found virus at the localities of Central Serbia, while PVY and CMV were the most frequent viruses in the Vojvodina Province...
2011: Acta Virologica
Mira Samardzic, Snezana Pavicevic, Michael Ludwig, Radovan Bogdanovic
INTRODUCTION: Dent's disease is an X-linked recessive proximal tubulopathy characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis and progressive renal failure. To the best of our knowledge, this is only the third report on the use of growth hormone therapy in a child with poor growth associated with Dent's disease. CASE PRESENTATION: We report on a 7-year-old Montenegrin boy with proteinuria, hypercalciuria, nephrocalcinosis, rickets and short stature with unimpaired growth hormone secretion...
2011: Journal of Medical Case Reports
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