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Mirjana Bakić, Marina Ratković, Branka Gledović, Balsa Vujović, Danilo Radunović, Vera Babić, Vladimir Prelević
Dear Editor, Tuberous sclerosis (TS) is an autosomal dominant multisystem disease, which occurs due to genetically determined hyperplasia of ectodermal and mesodermal cells. Clinical manifestations present on the skin and in the nervous system, kidneys, heart, and other organs. Recent studies estimate the incidence of TS at 1/6000 to 1/10,000 live births, and a prevalence in the general population of approximately 1 in 20,000 (1). There are two different genetic loci responsible for TS: 9q34 (TSC1-hamartin) and 16p13...
April 2018: Acta Dermatovenerologica Croatica: ADC
Yazmin Alcala-Canto, Juan Antonio Figueroa-Castillo, Froylán Ibarra-Velarde, Yolanda Vera-Montenegro, María Eugenia Cervantes-Valencia, Abdelfattah Z M Salem, Jorge Alfredo Cuéllar-Ordaz
The tick genus Ripicephalus (Boophilus), particularly R. microplus, is one of the most important ectoparasites that affects livestock health and considered an epidemiological risk because it causes significant economic losses due, mainly, to restrictions in the export of infested animals to several countries. Its spatial distribution has been tied to environmental factors, mainly warm temperatures and high relative humidity. In this work, we integrated a dataset consisting of 5843 records of Rhipicephalus spp...
May 7, 2018: Geospatial Health
Lucio Vilar, Julio Abucham, José Luciano Albuquerque, Luiz Antônio Araujo, Monalisa F Azevedo, Cesar Luiz Boguszewski, Luiz Augusto Casulari, Malebranche B C Cunha Neto, Mauro A Czepielewski, Felipe H G Duarte, Manuel Dos S Faria, Monica R Gadelha, Heraldo M Garmes, Andrea Glezer, Maria Helane Gurgel, Raquel S Jallad, Manoel Martins, Paulo A C Miranda, Renan M Montenegro, Nina R C Musolino, Luciana A Naves, Antônio Ribeiro-Oliveira Júnior, Cíntia M S Silva, Camila Viecceli, Marcello D Bronstein
Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, exceptions to these rules are not rare...
March 2018: Archives of Endocrinology and Metabolism
Christian C Figueroa, Eduardo Fuentes-Contreras, Marco A Molina-Montenegro, Claudio C Ramírez
In agroecosystems, introduced aphids that reproduce by obligate parthenogenesis (OP) show strong biased representation of a few genotypes (superclones), whereas species with cyclical parthenogenesis (CP) exhibit the opposite trend with many unique genotypes. We analyzed the biological and genetic features of 23 different aphid species introduced in different geographic areas and climates, finding putative superclones in about 60% of them. We have examined the proximal causes for aphid establishment and spread after their introduction, and found that OP, host availability, and phenotypic plasticity are among the main variables underpinning the ability of aphids to succeed in new geographic areas, which may explain the high potential for invasion in this group of pest insects...
April 2018: Current Opinion in Insect Science
Delanie Macedo, Monica M França, Luciana Montenegro, Marina Cunha-Silva, Danielle S Bessa, Ana Paula Abreu, Ursula B Kaiser, Berenice B Mendonca, Alexander A L Jorge, Vinicius N Brito, Ana C Latronico
<br>Context: Loss-of-function mutations in the coding region of MKRN3, a maternally imprinted gene at chromosome 15q11.2, are a common cause of familial central precocious puberty (CPP). Whether MKRN3 alterations in regulatory regions can cause CPP has not been explored to date. We aimed to investigate potential pathogenic variants in the promoter region of MKRN3 in patients with idiopathic CPP. Patients/ Methods: A cohort of 110 patients with idiopathic CPP was studied. Family history of precocious sexual development was present in 25%...
May 15, 2018: Neuroendocrinology
M Ratkovic, N Basic Jukic, Z Kastelan, D Radunovic, P Kavaric, J Brezak, M Topalovic Grkovic, T Hudolin, V Prelevic
Organ transplantation has prolonged and improved the lives of many patients around the world. However, a widespread shortage of donors remains the main factor that has led to organ trafficking and transplant tourism. To stop transplant tourism and to provide optimal treatment for its citizens with end-stage renal disease, Montenegro started performing renal transplantations in September 2012. Thirty-five transplantations have been performed since that time, 34 from living donors and only 1 from a deceased donor...
March 12, 2018: Transplantation Proceedings
Fernando S Montenegro, Marcelo Correia, Fabiana Muccillo, Christina G Souza E Silva, Andrea De Lorenzo
OBJECTIVE: Endothelial progenitor cells (EPCs) are produced in the bone marrow and mobilized to the peripheral blood playing a key role in endothelial repair. The objective of this study was to evaluate circulating EPC before and after percutaneous coronary intervention (PCI) with stent implantation and their associations with coronary restenosis and adverse cardiovascular events. Venous blood was obtained before and the day after PCI. Quantification of total white blood count and identification of EPCs (CD45- CD34+ CD31+ CD133/2+ CD309+ ) through immunophenotyping by flow cytometry was performed...
May 8, 2018: BMC Research Notes
Carla Beatriz Davi, Bruna Pinheiro de Moraes, Bruno Fontes Lichtenfels, João Batista Saldanha de Castro Filho, Marcelle Maria Portal, Rosangela Munhoz Montenegro, Roberto Ceratti Manfro
INTRODUCTION: Posterior reversible leukoencephalopathy syndrome (PRES) was first described by Hinchey in 1996. The syndrome is characterized by altered level of consciousness, headache, visual changes, and seizures associated with a vasogenic edema of the white matter that occurs predominantly in the occipital and parietal lobes. Imaging tests such as computed tomography (CT) and especially magnetic resonance imaging (MRI) support the diagnosis. CASE REPORT: We report a case of a 48-year-old female patient who underwent a deceased donor kidney transplant and received tacrolimus as a part of the immunosuppressive regimen...
April 19, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Lorella Pasquinucci, Carmela Parenti, Emanuele Amata, Zafiroula Georgoussi, Paschalina Pallaki, Valeria Camarda, Girolamo Calò, Emanuela Arena, Lucia Montenegro, Rita Turnaturi
(&minus;)- cis - N -Normetazocine represents a rigid scaffold able to mimic the tyramine moiety of endogenous opioid peptides, and the introduction of different N -substituents influences affinity and efficacy of respective ligands at MOR (mu opioid receptor), DOR (delta opioid receptor), and KOR (kappa opioid receptor). We have previously identified LP1, a MOR/DOR multitarget opioid ligand, with an N -phenylpropanamido substituent linked to (&minus;)- cis - N -Normetazocine scaffold. Herein, we report the synthesis, competition binding and calcium mobilization assays of new compounds 10 ⁻ 16 that differ from LP1 by the nature of the N -substituent...
May 5, 2018: Pharmaceuticals
Ana V Pejcic, Georgi Iskrov, Mihajlo Michael Jakovljevic, Rumen Stefanov
The aim of this study was to compare orphan drug access in a sample of Balkan countries: five EU Member States (Bulgaria, Croatia, Greece, Romania, Slovenia) and two EU Candidates (Serbia, Montenegro). The comparative analysis was based on a cross-sectional study and included medicinal products with an active orphan designation and market authorisation on January 1, 2017. Access to orphan drugs is an ongoing challenge in these countries. Three clusters of countries were identified in terms of orphan drug access: Greece and Slovenia, making the top tier, Romania, Bulgaria, and Croatia, being in the middle, and EU Candidates, Serbia and Montenegro, forming the bottom tier, where a substantial number of EU market approved orphan drugs was not even registered...
April 26, 2018: Health Policy
David H Huber, Ifeoma R Ugwuanyi, Sridhar A Malkaram, Natalia A Montenegro-Garcia, Vadesse Lhilhi Noundou, Jesus E Chavarria-Palma
We sequenced two metagenomes from upper sediment layers (0 to 5 and 6 to 10 cm) from the Kanawha River, West Virginia. The watershed includes inputs from the forested Appalachian Mountains, surface coal mining, municipal residues, and extensive chemical manufacturing. The dominant bacterial phyla were Proteobacteria , Bacteriodetes , Firmicutes , Actinobacteria , and Chloroflexi Xenobiotic degradation pathways were present.
May 3, 2018: Genome Announcements
Bozidarka Rakocevic, Anita Grgurevic, Goran Trajkovic, Vedrana Pavlovic, Sandra Sipetic Grujicic, Danijela Vujosevic, Sanja Medenica, Zoran Vratnica, Olivera Bojovic, Boban Mugosa
AIM: The study aim was to analyze epidemiology and clinical characteristics of severe acute respiratory infection (SARI) cases and to compare demographic and clinical characteristics as well as outcomes of influenza-positive SARI cases to those of influenza-negative SARI cases in Montenegro. METHODS: SARI surveillance was established in 2014 in nine healthcare institutions. Retrospective analysis of case-based surveillance data pertaining to all reported SARI cases during three seasons was conducted...
May 3, 2018: Current Medical Research and Opinion
Leticia García-Rico, Diana Meza-Figueroa, A Jay Gandolfi, Carlos Ibañez Del Rivero, Marco A Martínez-Cinco, Maria M Meza-Montenegro
Environmental arsenic exposure is associated with increased risk of non-cancerous chronic diseases and a variety of cancers in humans. The aims of this study were to carry out for the first time a health risk assessment for two common arsenic exposure routes (drinking water and soil ingestion) in children living in the most important agricultural areas in the Yaqui and Mayo valleys in Sonora, Mexico. Drinking water sampling was conducted in the wells of 57 towns. A cross-sectional study was done in 306 children from 13 villages in the valleys...
May 2, 2018: Biological Trace Element Research
Marisa Juanes, Irene Lostalé-Seijo, Juan R Granja, Javier Montenegro
The intracellular transport of exogenous proteins has emerged as one of the most promising methodologies for biotechnology and chemical biology. Current protein delivery is mainly approached by liposome encapsulation, translational fusion and ionic/hydrophobic non-covalent aggregation with transporting molecular vehicles. We here introduce the concept of supramolecular recognition and selective transport of proteins by peptide hybrid materials. We have designed a helical amphiphilic cationic peptide that bears two orthogonal alkoxyamines for the precise anchoring of protein ligands...
April 27, 2018: Chemistry: a European Journal
Sergio Setsuo Maeda, Carolina Aguiar Moreira, Victória Zeghbi Cochenski Borba, Francisco Bandeira, Maria Lucia Fleiuss de Farias, João Lindolfo Cunha Borges, Francisco José Albuquerque de Paula, Felipe Augusto Brasileiro Vanderlei, Fábio Luiz de Menezes Montenegro, Rodrigo Oliveira Santos, Bruno Ferraz-de-Souza, Marise Lazaretti-Castro
Objective To present an update on the diagnosis and treatment of hypoparathyroidism based on the most recent scientific evidence. Materials and methods The Department of Bone and Mineral Metabolism of the Sociedade Brasileira de Endocrinologia e Metabologia (SBEM; Brazilian Society of Endocrinology and Metabolism) was invited to prepare a document following the rules set by the Guidelines Program of the Associação Médica Brasileira (AMB; Brazilian Medical Association). Relevant papers were retrieved from the databases MEDLINE/PubMed, LILACS, and SciELO, and the evidence derived from each article was classified into recommendation levels according to scientific strength and study type...
February 2018: Archives of Endocrinology and Metabolism
Daniel Eid, Miguel Guzman-Rivero, Ernesto Rojas, Isabel Goicolea, Anna-Karin Hurtig, Daniel Illanes, Miguel San Sebastian
Background: Cutaneous leishmaniasis (CL) is an endemic disease in Bolivia, particularly in the rainforest of Cochabamba, in the municipality of Villa Tunari. The precarious, dispersed, and poorly accessible settlements in these farming communities make it difficult to study them, and there are no epidemiological studies in the area. The aim of the present study was to identify the risk factors associated with cutaneous leishmaniasis. Methods: A cross-sectional study was conducted in August 2015 and August 2016 in two communities of Villa Tunari, Cochabamba...
2018: Tropical Medicine and Health
Cristian R Montenegro
Although the organisation of mental health service users and ex-users in Latin America is a recent and under-researched phenomenon, global calls for their involvement in policy have penetrated national agendas, shaping definitions and expectations about their role in mental health systems. In this context, how such groups react to these expectations and define their own goals, strategies and partnerships can reveal the specificity of the "user movement" in Chile and Latin America. This study draws on Jacques Rancière's theorisation of "police order" and "politics" to understand the emergence of users' collective identity and activism, highlighting the role of practices of disengagement and rejection...
April 24, 2018: Culture, Medicine and Psychiatry
Filip Franeta
Montenegro is, from an entomological point of view, one of the least studied countries in Europe. The Lepidoptera order has been severely understudied and an updated butterfly checklist has not been published for more than 30 years. Without proper knowledge on the species composition, and their distribution throughout the country, appropriate conservation measures cannot be undertaken. Thus an updated checklist of the butterflies of Montenegro was urgently needed. In this paper a list of 192 species of butterflies is presented, based on all available literature and on the authors' own data gathered from 1998 to 2017...
March 7, 2018: Zootaxa
Vladimir PeŠiĆ, Aleksandra BaŃkowska, Tom Goldschmidt, MichaŁ Grabowski, Grzegorz MichoŃski, Andrzej Zawal
The last checklist of the water mites of the Balkan countries published in 2010 by Pešić et al. is updated to November 2017. This supplement includes new records of water mite species from the Balkan countries (Croatia, Bosnia Herzegovina, Montenegro, Albania, Macedonia, Serbia, Bulgaria and Greece) published after 2010, as well as unpublished records based on material collected from Croatia, Montenegro, Albania, Macedonia, and Greece. Numerous new records for the national faunas, including one species new for the Mediterranean region (Arrenurus stjordalensis Thor, 1899), are reported and one species new to science (Trichothyas jadrankae Pešić sp...
March 13, 2018: Zootaxa
Francisca Kalline de Almeida Barreto, Renan Magalhães Montenegro, Virginia Oliveira Fernandes, Rhaquel Oliveira, Lívia Aline de Araújo Batista, Akhtar Hussain, Luciano Pamplona de Góes Cavalcanti
Background: Chikungunya (CHIK) is a viral disease transmitted by mosquitoes. The first cases in Brazil were confirmed in 2014. Between 2016 and 2017, over 300,000 cases were identified during this period, with nearly 300 deaths. The clinical manifestations, pathogenesis and risk factors for occurrence of severe cases are not yet well understood, although it is known that the severity of the cases is associated with the presence of comorbidities, especially diabetes mellitus (DM). Objective: To review the medical literature for the associations between DM and CHIK and to understand the potential impact on metabolic state and its complications...
2018: Diabetology & Metabolic Syndrome
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