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https://www.readbyqxmd.com/read/28329741/drugs-violence-and-trauma-in-m%C3%A3-xico-and-united-states
#1
Juan Carlos Puyana, Juan Carlos Jacob Puyana, Andres Mariano Rubiano, Jorge Hernan Montenegro, Glyn O Estebanez, Alvaro Ignacio Sanchez, Felipe Vega-Rivera
The impact of illicit drug markets on the occurrence of violence varies tremendously depending on many factors. Over the last years, Mexico and United States (US) has increased security border issues that included many aspects of drug-related trade and criminal activities. Mexico experienced only a small reduction of trauma deaths after severe crime reinforcement policies. This strategy in the war on drugs is shifting the drug market to other Central American countries. This phenomenon is called the ballooning effect where by pressure to control illicit drug related activities in one particular area forces a shift to other more vulnerable areas that lead to increase crime and violence...
March 21, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28328617/cutaneous-mastocytosis-with-atypical-mast-cells-in-a-7-year-old-girl
#2
Gabriel Marrero Alemán, Constantin El Habr, Diana Islas Norris, Társila Montenegro Dámaso, Leopoldo Borrego, Omar P Sangueza
Cutaneous mastocytosis is defined by the presence of mast cells within the skin in the absence of other criteria for the diagnosis of systemic mastocytosis. Mast cells are characterized by an abundant granular cytoplasm and a round to oval or spindle-shaped nuclei. The presence of mast cells with bilobed and multilobed nuclei in cutaneous mastocytosis is a rare phenomenon and has been rarely reported in the literature. To our knowledge, there are only 4 reported cases of cutaneous mastocytosis with atypical mast cells...
April 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28324015/paternally-inherited-dlk1-deletion-associated-with-familial-central-precocious-puberty
#3
Andrew Dauber, Marina Cunha-Silva, Delanie B Macedo, Vinicius N Brito, Ana Paula Abreu, Stephanie A Roberts, Luciana R Montenegro, Melissa Andrew, Andrew Kirby, Matthew T Weirauch, Guillaume Labilloy, Danielle S Bessa, Rona S Carroll, Dakota C Jacobs, Patrick E Chappell, Berenice B Mendonca, David Haig, Ursula B Kaiser, Ana Claudia Latronico
Context: Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal axis. Few genetic causes of CPP have been identified with the most common being mutations in the paternally expressed imprinted gene MKRN3. Objective: To identify the genetic etiology of CPP in a large multigenerational family. Design: Linkage analysis followed by whole genome sequencing was performed in a family with 5 female members with nonsyndromic CPP...
January 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28303587/different-antibiotic-protocols-in-the-treatment-of-severe-chronic-periodontitis-a-1-year-randomized-trial
#4
Ivan Borges, Marcelo Faveri, Luciene Cristina Figueiredo, Poliana Mendes Duarte, Belén Retamal-Valdes, Sheyla Christinne Lira Montenegro, Magda Feres
AIM: To evaluate the clinical effects of different dosages of metronidazole (MTZ) and durations of MTZ+amoxicillin (AMX) in the treatment of generalized chronic periodontitis (GChP). MATERIAL AND METHODS: Subjects with GChP were randomly assigned to receive scaling and root planing (SRP)-only, or combined with 250mg or 400mg of MTZ+AMX (500mg) thrice a day (TID), for 7 or 14 days. Subjects were monitored for 1 year. RESULTS: 109 subjects were enrolled...
March 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28300520/hypnosis-as-a-valuable-tool-for-surgical-procedures-in-the-oral-and-maxillofacial-area
#5
Gil Montenegro, Luiza Alves, Ana Luiza Zaninotto, Denise Pinheiro Falcão, Rivadávio Fernandes Batista de Amorim
Hypnosis is a valuable tool in the management of patients who undergo surgical procedures in the maxillofacial complex, particularly in reducing and eliminating pain during surgery and aiding patients who have dental fear and are allergic to anesthesia. This case report demonstrates the efficacy of hypnosis in mitigating anxiety, bleeding, and pain during dental surgery without anesthesia during implant placement of tooth 14, the upper left first molar.
April 2017: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/28288773/serological-detection-of-antibodies-to-anaplasma-spp-borrelia-burgdorferi-sensu-lato-and-ehrlichia-canis-and-of-dirofilaria-immitis-antigen-in-dogs-from-costa-rica
#6
Víctor M Montenegro, Marta C Bonilla, Darwin Kaminsky, Juan José Romero-Zúñiga, Susanne Siebert, Friederike Krämer
In a study in Costa Rica 314 serum samples from dogs throughout all seven provinces were tested using a commercial kit for the detection of circulating antibodies against Anaplasma spp., Borrelia burgdorferi sensu lato and Ehrlichia canis, and of circulating antigen of Dirofilaria immitis. A total of 6.4% (20/314) and 38.2% (120/314) were positive for Anaplasma spp. (An) and E. canis (Ec) antibodies. Overall, 8.0% (25/314) were positive for D. immitis (Di) antigen. One single dog reacted positive with B. burgdorferi s...
March 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28288454/validation-of-the-nuclear-cataract-grading-system-bcn-10
#7
Rafael I Barraquer, Laura Pinilla Cortés, Miriam J Allende, Gustavo A Montenegro, Bozidar Ivankovic, Justin Christopher D'Antin, Hernán Martínez Osorio, Ralph Michael
PURPOSE: To evaluate a new nuclear cataract grading system which is intended as a surgical guidance system to predict lens hardness before cataract surgery. METHODS: The new BCN 10 grading system consists of frontal and cross-sectional slit-lamp images of human eye lenses, ranging from a completely transparent lens nucleus to a totally black nuclear cataract. Validation was done with 9 observers for 110 cases. Two modalities were applied, and observers were asked to use only whole digits and then half digits for grading...
March 14, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28287290/prenatal-ultrasound-diagnosis-of-tessier-number-7-cleft-case-report-and-review-of-the-literature
#8
João Cavaco-Gomes, Carla Duarte, Elsa Pereira, Alexandra Matias, Nuno Montenegro, Eberhard Merz
Lateral or transverse facial clefts are the most frequent of the atypical facial clefts, classified by Tessier as no. 7 clefts. Most of the cases are diagnosed at birth, while few cases are diagnosed prenatally. We report a case of prenatal ultrasound detection and three-dimensional characterisation of a lateral facial cleft at 21 weeks of gestation, which was terminated at 22 weeks. It was a transverse cleft, running through the left cheek towards the ear, along with micrognathia and mild polyhydramnios. We also present a review on classification, anatomical features and prenatal diagnosis of Tessier no...
March 13, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28286853/paradoxical-embolism-due-to-persistent-foramen-ovale-a-case-report
#9
Dormar David Barrios, Jonathan Roncancio, Albert Alejandro Avila, Jaime Andrés Alvarado, Ana Cristina Montenegro
The mean percentage of cryptogenic strokes among ischemic strokes is 31%, of which one-third may be associated with patent foramen ovale. The foramen ovale is required for blood flow through the fetal atrial septum. It is formed as of the fourth week of gestation, and this leads to right-left interatrial shunt that allows the passage of oxygenated blood to systemic circulation. In 75% of cases, its closure is complete by 2 years of age, but it may persist in 25% of patients. We present the case of a patient with paradoxical embolism in the lower extremities and ischemic stroke in the clinical context of a patent foramen ovale...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28278676/comparative-analytical-study-of-the-selected-wine-varieties-grown-in-montenegro
#10
Neda O Đorđević, Miroslav M Novaković, Boris Pejin, Jelena J Mutić, Vlatka E Vajs, Snežana B Pajović, Vele V Tešević
Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R = 0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65 mg/L, respectively)...
February 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28277916/effect-of-antenatal-corticosteroids-on-morbidity-and-mortality-of-preterm-singletons-and-twins
#11
Ana Vaz, Maria Filipa Malheiro, Milton Severo, Teresa Rodrigues, Hercília Guimarães, Nuno Montenegro
PURPOSE: Compare the effect of antenatal corticosteroids (ACS) on neonatal outcomes among singleton and twin pregnancies and the impact of completeness and timing of ministration. MATERIALS AND METHODS: Retrospective cohort study involving 951 preterm deliveries (25(+0)-34(+6)weeks), between 2006 and 2015. Neonatal outcomes were evaluated according to completeness of ACS ("Complete" n = 441;"Rescue" n = 38;"Incomplete" n = 175;"No ACS" n = 98) and timing of therapy related to delivery ("Before 7 days" n = 260; "After 7 days" n = 181)...
February 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28277271/change-over-time-in-parents-beliefs-about-and-reported-use-of-corporal-punishment-in-eight-countries-with-and-without-legal-bans
#12
Jennifer E Lansford, Claudia Cappa, Diane L Putnick, Marc H Bornstein, Kirby Deater-Deckard, Robert H Bradley
Stopping violence against children is prioritized in goal 16 of the Sustainable Development Goals adopted by the United Nations General Assembly in 2015. All forms of child corporal punishment have been outlawed in 50 countries as of October 2016. Using data from 56,371 caregivers in eight countries that participated in UNICEF's Multiple Indicator Cluster Survey, we examined change from Time 1 (2005-6) to Time 2 (2008-13) in national rates of corporal punishment of 2- to 14-year-old children and in caregivers' beliefs regarding the necessity of using corporal punishment...
October 27, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28277172/encapsulated-whey-native-yeast-kluyveromyces-marxianus-as-a-feed-additive-for-animal-production
#13
Ladislao Díaz-Vergara, Carina Maricel Pereyra, Mariana Montenegro, Gabriela Alejandra Pena, Carla Ayelen Aminahuel, Lilia R Cavaglieri
Whey is the main byproduct of the cheese industry. While the composition is variable, it retains up to 55% of milk nutrients. The beneficial features of whey indicates a promising source of new potentially probiotic strains for the development of food additives destined for animal production. The aim of this study was to identify Kluyveromyces spp. isolated from whey, to study some probiotic properties and to select the best strain to be encapsulated using derivatised chitosan. Kluyveromyces marxianus strains (VM003, VM004 and VM005) were isolated from whey and identified by phenotypic and molecular techniques...
March 6, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28274418/potentiometric-perchlorate-determination-at-nanomolar-concentrations-in-vegetables
#14
Dilmo M S Leoterio, Ana Paula S Paim, Mônica F Belian, André Galembeck, André F Lavorante, Edgar Pinto, Célia G Amorim, Alberto N Araújo, Maria C B S M Montenegro
In this work, an expeditious method based on the multi-commutated flow-analysis concept with potentiometric detection is proposed to perform determinations of the emergent contaminant perchlorate in vegetable matrices down to nanomolar concentration. To accomplish the task, a tubular shaped potentiometric sensor selective to perchlorate ion was constructed with a PVC membrane containing 12mmol/kg of the polyamine bisnaphthalimidopropyl-4,4'-diaminodiphenylmethane and 2-nitrophenyl phenyl ether 68% (w/w) as plasticizer casted on a conductive epoxy resin...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28271563/gastric-cancer-managment-kinases-as-a-target-therapy
#15
Batoul Farran, Susanne Müller, Raquel C Montenegro
The molecular diagnostics revolution has reshaped the practice of oncology by facilitating the identification of genetic, epigenetic and proteomic modifications correlated with cancer, thus delineating 'oncomaps' for various cancer types. These advances have enhanced our understanding of gastric cancer, one of the most fatal diseases worldwide, and culminated in the approval of novel molecular therapies such as trastuzumab. Gastric tumours display recurrent aberrations in key kinase oncogenes such as Her2, EGFR, PI3K, mTOR or c-Met, suggesting that these receptors are amenable to inhibition using specific drug agents...
March 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28265301/assessing-histone-demethylase-inhibitors-in-cells-lessons-learned
#16
Stephanie B Hatch, Clarence Yapp, Raquel C Montenegro, Pavel Savitsky, Vicki Gamble, Anthony Tumber, Gian Filippo Ruda, Vassilios Bavetsias, Oleg Fedorov, Butrus Atrash, Florence Raynaud, Rachel Lanigan, LeAnne Carmichael, Kathy Tomlin, Rosemary Burke, Susan M Westaway, Jack A Brown, Rab K Prinjha, Elisabeth D Martinez, Udo Oppermann, Christopher J Schofield, Chas Bountra, Akane Kawamura, Julian Blagg, Paul E Brennan, Olivia Rossanese, Susanne Müller
BACKGROUND: Histone lysine demethylases (KDMs) are of interest as drug targets due to their regulatory roles in chromatin organization and their tight associations with diseases including cancer and mental disorders. The first KDM inhibitors for KDM1 have entered clinical trials, and efforts are ongoing to develop potent, selective and cell-active 'probe' molecules for this target class. Robust cellular assays to assess the specific engagement of KDM inhibitors in cells as well as their cellular selectivity are a prerequisite for the development of high-quality inhibitors...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28239475/long-term-cognitive-outcomes-among-unselected-ventilated-and-non-ventilated-icu-patients
#17
José Raimundo A de Azevedo, Widlani Sousa Montenegro, Djane Pereira Rodrigues, Suellen C de C Souza, Vanessa F S Araujo, Margareth Pereira de Paula, Patricia H C P Prazeres, Adenilde da Luz Leitão, Adriana V N Mendonça
BACKGROUND: Cognitive dysfunction is an important long-term complication of critical illness associated with reduced quality of life, increase in healthcare costs, and institutionalization. Delirium, an acute form of brain dysfunction that is common during critical illness has been shown to be associated with long-term cognitive dysfunction. The aim of this prospective cohort study was to estimate the prevalence and severity of cognitive dysfunction in an unselected population of medical and surgical ICU patients...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28236805/-toxicity-for-warfarine-switching-from-lopinavir-ritonavir-to-dolutegravir
#18
Ana Pelufo-Pellicer, MªÁngeles López-Montenegro Soria
No abstract text is available yet for this article.
March 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28231469/bassoon-controls-presynaptic-autophagy-through-atg5
#19
Nathan D Okerlund, Katharina Schneider, Sergio Leal-Ortiz, Carolina Montenegro-Venegas, Sally A Kim, Loren C Garner, Eckart D Gundelfinger, Richard J Reimer, Craig C Garner
Mechanisms regulating the surveillance and clearance of synaptic proteins are not well understood. Intriguingly, the loss of the presynaptic active zone proteins Piccolo and Bassoon triggers the loss of synaptic vesicles (SVs) and compromises synaptic integrity. Here we report that the destruction of SVs in boutons lacking Piccolo and Bassoon was associated with the induction of presynaptic autophagy, a process that depended on poly-ubiquitination, but not the E3 ubiquitin ligase Siah1. Surprisingly, gain or loss of function (LOF) of Bassoon alone suppressed or enhanced presynaptic autophagy, respectively, implying a fundamental role for Bassoon in the local regulation of presynaptic autophagy...
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28231383/the-pangenome-of-hexaploid-bread-wheat
#20
Juan D Montenegro, Agnieszka A Golicz, Philipp E Bayer, Bhavna Hurgobin, HueyTyng Lee, Chon-Kit Kenneth Chan, Paul Visendi, Kaitao Lai, Jaroslav Doležel, Jacqueline Batley, David Edwards
There is an increasing understanding that gene presence absence variation plays an important role in the heritability of agronomic traits, however there have been relatively few studies on gene presence absence variation in crop species. Hexaploid wheat is one of the most important food crops in the world and intensive breeding has reduced the genetic diversity of elite cultivars. Major efforts have produced draft genome assemblies for the cultivar Chinese Spring, but it is unknown how well this represents the genome diversity found in current modern elite cultivars...
February 23, 2017: Plant Journal: for Cell and Molecular Biology
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