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https://www.readbyqxmd.com/read/27883082/alpha-band-disruption-in-the-ad-continuum-starts-in-the-subjective-cognitive-decline-stage-a-meg-study
#1
D López-Sanz, R Bruña, P Garcés, C Camara, N Serrano, I C Rodríguez-Rojo, M L Delgado, M Montenegro, R López-Higes, M Yus, F Maestú
The consideration of Subjective Cognitive Decline (SCD) as a preclinical stage of AD remains still a matter of debate. Alpha band alterations represent one of the most significant changes in the electrophysiological profile of AD. In particular, AD patients exhibit reduced alpha relative power and frequency. We used alpha band activity measured with MEG to study whether SCD and MCI elders present these electrophysiological changes characteristic of AD, and to determine the evolution of the observed alterations across AD spectrum...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27871801/lipid-profiling-of-polarized-human-monocyte-derived-macrophages
#2
J Rafael Montenegro-Burke, Jessica A Sutton, Lisa M Rogers, Ginger L Milne, John A McLean, David M Aronoff
The highly orchestrated transcriptional and metabolic reprogramming during activation drastically transforms the main functions and physiology of human macrophages across the polarization spectrum. Lipids, for example, can modify protein function by acting remotely as signaling molecules but also locally by altering the physical properties of cellular membranes. These changes play key roles in the functions of highly plastic immune cells due to their involvement in inflammation, immune responses, phagocytosis and wound healing processes...
November 15, 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/27866209/local-ecological-knowledge-about-endangered-primates-in-a-rural-community-in-para%C3%A3-ba-brazil
#3
Emanuel Ubaldino Torres Junior, Mônica Mafra Valença-Montenegro, Carla Soraia Soares de Castro
The study of local ecological knowledge (LEK) fosters a better understanding of the relationship between humans and the environment. We assessed respondents' ecological knowledge of primates in a rural community located near the Atlantic Forest remnants in the state of Paraíba, Brazil. Populations of Alouatta belzebul (red-handed howler monkeys), Sapajus flavius (blonde capuchins), and Callithrix jacchus (the common marmoset) inhabit the region. We conducted 200 semi-structured interviews and applied thematic content analysis, with weighting, to the responses to quantify the LEK...
2016: Folia Primatologica; International Journal of Primatology
https://www.readbyqxmd.com/read/27864762/in-silico-methods-for-cell-annotation-quantification-of-gene-expression-and-cell-geometry-at-single-cell-resolution-using-3dcellatlas
#4
Petra Stamm, Soeren Strauss, Thomas D Montenegro-Johnson, Richard Smith, George W Bassel
A comprehensive understanding of plant growth and development requires the integration of the spatial and temporal dynamics of gene regulatory networks with changes in cellular geometry during 3D organ growth. 3DCellAtlas is an integrative computational pipeline that semi-automatically identifies cell type and position within radially symmetric plant organs, and simultaneously quantifies 3D cell anisotropy and reporter abundance at single-cell resolution. It is a powerful tool that generates digital single-cell cellular atlases of plant organs and enables 3D cell geometry and reporter abundance (gene/protein/biosensor) from multiple samples to be integrated at single-cell resolution across whole organs...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27863420/ywhae-silencing-induces-cell-proliferation-invasion-and-migration-through-the-up-regulation-of-cdc25b-and-myc-in-gastric-cancer-cells-new-insights-about-ywhae-role-in-the-tumor-development-and-metastasis-process
#5
Mariana Ferreira Leal, Helem Ferreira Ribeiro, Juan Antonio Rey, Giovanny Rebouças Pinto, Marília Cardoso Smith, Caroline Aquino Moreira-Nunes, Paulo Pimentel Assumpção, Leticia Martins Lamarão, Danielle Queiroz Calcagno, Raquel Carvalho Montenegro, Rommel Rodriguez Burbano
We previously observed reduced YWHAE (14-3-3ε) protein expression in a small set of gastric cancer samples. YWHAE may act as a negative regulator of the cyclin CDC25B, which is a transcriptional target of MYC oncogene. The understanding of YWHAE role and its targets is important for the better knowledge of gastric carcinogenesis. Thus, we aimed to evaluate the relationship among YWHAE, CDC25B, and MYC in vitro and in vivo. For this, we analyzed the YWHAE, CDC25B, and MYC expression in YWHA-silenced, CDC25B-silenced, and MYC-silenced gastric cancer cell lines, as well as in gastric cancer and non-neoplastic gastric samples...
November 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27819753/a-new-material-to-prevent-urethral-damage-after-implantation-of-artificial-devices-an-experimental-study
#6
Salvador Vilar Correia Lima, Marcilio Romero Machado, Flávia Cristina Morone Pinto, Mariana Montenegro de Melo Lira, Amanda Vasconcelos de Albuquerque, Eugênio Soares Lustosa, Jaiurte Gomes Martins da Silva, Olávio Campos
OBJECTIVE: To validate the application of the bacterial cellulose (BC) membrane as a protecting bar-rier to the urethra. MATERIALS AND METHODS: Forty female Wistar rats (four groups of 10): Group 1 (sham), the urethra was dissected as in previous groups and nothing applied around; Group 2, received a 0.7cm strip of the BC applied around the urethra just below the bladder neck; Group 3, received a silicon strip with the same dimensions as in group 2; Group 4, had a combination of 2 and 3 groups being the silicon strip applied over the cellu¬losic material...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27818976/does-the-suction-drain-diameter-matter-bleeding-analysis-after-total-knee-replacement-comparing-different-suction-drain-gauges
#7
Marcos George de Souza Leao, Gladys Martins Pedroza Neta, Thiago Montenegro da Silva, Yacov Machado Costa Ferreira, Waryla Raissa Vasconcelos Dias
OBJECTIVES: To evaluate bleeding and the estimated blood loss in patients who underwent total knee replacement (TKR) with different closed suction drains (3.2-mm and 4.8-mm gauge). METHODS: This was a randomized controlled trial with 22 patients who underwent TKR and were divided into two groups: Group I, with 11 patients in whom the 3.2-mm suction drain was used, and Group II, with 11 patients in whom the 4.8-mm suction drain was used. The hematocrit was measured after 24, 48 and 72 h after surgery in order to calculate the estimated blood loss...
September 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/27810735/profound-differences-between-humans-and-rodents-in-the-ability-to-concentrate-salivary-nitrate-implications-for-translational-research
#8
Marcelo F Montenegro, Michaela L Sundqvist, Carina Nihlén, Michael Hezel, Mattias Carlström, Eddie Weitzberg, Jon O Lundberg
In humans dietary circulating nitrate accumulates rapidly in saliva through active transport in the salivary glands. By this mechanism resulting salivary nitrate concentrations are 10-20 times higher than in plasma. In the oral cavity nitrate is reduced by commensal bacteria to nitrite, which is subsequently swallowed and further metabolized to nitric oxide (NO) and other bioactive nitrogen oxides in blood and tissues. This entero-salivary circulation of nitrate is central in the various NO-like effects observed after ingestion of inorganic nitrate...
October 25, 2016: Redox Biology
https://www.readbyqxmd.com/read/27809263/in-vitro-antimicrobial-activity-of-embothrium-coccineum-used-as-traditional-medicine-in-patagonia-against-multiresistant-bacteria
#9
Nicole Canales, Iván Montenegro, Mario Párraga, Yusser Olguín, Patricio Godoy, Enrique Werner, Alejandro Madrid
Embothrium coccineum J.R. Forst. & G. Forst is an evergreen tree that has been used as a folk remedy for the treatment of neuralgia, tooth pains, wound healing, and glandular conditions, as well as an antiseptic agent against bacterial infection. The antibacterial activities of sequential extracts (hexane, dichloromethane, ethyl acetate, and ethanol) from the leaves of E. coccineum were evaluated by means of the micro-dilution assay against six (Escherichia coli; Klebsiella pneumoniae; Proteus mirabilis; Pseudomonas aeruginosa; Staphylococcus aureus and Streptococcus pyogenes) multiresistant bacteria strains...
October 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27802417/blood-pressure-lowering-effect-of-orally-ingested-nitrite-is-abolished-by-a-proton-pump-inhibitor
#10
Marcelo F Montenegro, Michaela L Sundqvist, Filip J Larsen, Zhengbing Zhuge, Mattias Carlström, Eddie Weitzberg, Jon O Lundberg
Inorganic nitrate and nitrite from dietary and endogenous sources are metabolized to NO and other bioactive nitrogen oxides that affect blood pressure. The mechanisms for nitrite bioactivation are unclear, but recent studies in rodents suggest that gastric acidity may influence the systemic effects of this anion. In a randomized, double-blind, placebo-controlled crossover study, we tested the effects of a proton pump inhibitor on the acute cardiovascular effects of nitrite. Fifteen healthy nonsmoking, normotensive subjects, aged 19 to 39 years, were pretreated with placebo or esomeprazole (3×40 mg) before ingesting sodium nitrite (0...
October 31, 2016: Hypertension
https://www.readbyqxmd.com/read/27791145/using-seafaring-simulations-and-shortest-hop-trajectories-to-model-the-prehistoric-colonization-of-remote-oceania
#11
Álvaro Montenegro, Richard T Callaghan, Scott M Fitzpatrick
The prehistoric colonization of islands in Remote Oceania that began ∼3400 B.P. represents what was arguably the most expansive and ambitious maritime dispersal of humans across any of the world's seas or oceans. Though archaeological evidence has provided a relatively clear picture of when many of the major island groups were colonized, there is still considerable debate as to where these settlers originated from and their strategies/trajectories used to reach habitable land that other datasets (genetic, linguistic) are also still trying to resolve...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27788533/24-7-presence-of-medical-staff-in-the-labor-ward-no-day-night-differences-in-perinatal-and-maternal-outcomes
#12
Sara Tavares, João Cavaco-Gomes, Marina Moucho, Milton Severo, Mário Mateus, Carla Ramalho, Gerard H A Visser, Nuno Montenegro
Objective The objective of this study was to assess possible day-night differences in perinatal and maternal labor outcomes in a hospital setting with no day-night differences in the presence of experienced medical staff. Design This was a retrospective study conducted over 5 years between 2008 and 2012. Setting This study was set at the obstetric delivery unit in a tertiary hospital. Population A total of 9,143 singleton deliveries were assessed after 34 weeks of gestation and after exclusion of major congenital malformations, inductions of labor, and elective cesarean sections...
October 27, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27777478/clinical-and-radiological-correlations-in-patients-with-gestational-trophoblastic-disease
#13
Lana de Lourdes Aguiar Lima, Raphael Câmara Medeiros Parente, Izildinha Maestá, Joffre Amim Junior, Jorge Fonte de Rezende Filho, Carlos Antonio Barbosa Montenegro, Antônio Braga
Gestational trophoblastic disease is an abnormality of pregnancy that encompasses a group of diseases that differ from each other in their propensity for regression, invasion, metastasis, and recurrence. In the past, it was common for patients with molar pregnancy to present with marked symptoms: copious bleeding; theca lutein cysts; uterus larger than appropriate for gestational age; early preeclampsia; hyperemesis gravidarum; and hyperthyroidism. Currently, with early diagnosis made by ultrasound, most patients are diagnosed while the disease is still in the asymptomatic phase...
July 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27776181/biological-interactions-and-simulated-climate-change-modulates-the-ecophysiological-performance-of-colobanthus-quitensis-in-the-antarctic-ecosystem
#14
Cristian Torres-Díaz, Jorge Gallardo-Cerda, Paris Lavin, Rómulo Oses, Fernando Carrasco-Urra, Cristian Atala, Ian S Acuña-Rodríguez, Peter Convey, Marco A Molina-Montenegro
Most climate and environmental change models predict significant increases in temperature and precipitation by the end of the 21st Century, for which the current functional output of certain symbioses may also be altered. In this context we address the following questions: 1) How the expected changes in abiotic factors (temperature, and water) differentially affect the ecophysiological performance of the plant Colobanthus quitensis? and 2) Will this environmental change indirectly affect C. quitensis photochemical performance and biomass accumulation by modifying its association with fungal endophytes? Plants of C...
2016: PloS One
https://www.readbyqxmd.com/read/27756797/sex-differences-in-the-epidemiology-of-new-onset-in-hospital-post-coronary-artery-bypass-graft-surgery-atrial-fibrillation-a-large-multicenter-study
#15
Giovanni Filardo, Gorav Ailawadi, Benjamin D Pollock, Briget da Graca, Danielle M Sass, Teresa K Phan, Debbie E Montenegro, Vinod Thourani, Ralph Damiano
BACKGROUND: New-onset atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG) is associated with increased morbidity and poorer long-term survival. Although many studies show differences in outcome in women versus men after CABG, little is known about the sex-specific incidence and characteristics of post-CABG AF. METHODS AND RESULTS: Overall, 11 236 consecutive patients without preoperative AF underwent isolated CABG from 2002 to 2010 at 4 US academic medical centers and 1 high-volume specialty cardiac hospital...
October 18, 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/27745738/determination-of-hydrocarbons-transported-by-urban-runoff-in-sediments-of-s%C3%A3-o-gon%C3%A3-alo-channel-pelotas-rs-brazil
#16
Pedro J Sanches Filho, Emerson M Böhm, Giani M B Böhm, Gissele O Montenegro, Lucas A Silveira, Glauco R Betemps
A high concentration of hydrocarbons in the environment is indicative of pollution. To evaluate the effect of hydrocarbons transported by urban runoff, the present study analyzed total petroleum hydrocarbons (TPHs), aliphatic hydrocarbons (AHs), unresolved complex mixture (UCM), and n-alkanes of the sediments of the canal that cross the urban area of Pelotas, Rio Grande do Sul, Brazil. The carbon preference index (CPI), terrigenous/aquatic ratio (TAR), and pristane/phytane ratio were determined. The TPH content ranged from 177,043...
October 11, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27739009/inkjet-printing-of-proteins-an-experimental-approach
#17
Miguel Montenegro-Nicolini, Víctor Miranda, Javier O Morales
Peptides and proteins represent a promissory group of molecules used by the pharmaceutical industry for drug therapy with great potential for development. However, the administration of these molecules presents a series of difficulties, making necessary the exploration of new alternatives like the buccal route of administration to improve drug therapy compliance. Although drop-on demand printers have been explored for small molecule drugs with promising results, the development of delivery systems for peptides and proteins through inkjet printing has seen little development...
October 13, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27729245/effectiveness-of-an-immunohistochemical-protocol-for-leishmania-detection-in-different-clinical-forms-of-american-tegumentary-leishmaniasis
#18
Fernanda A Marques, Rodrigo P Soares, Gregório G Almeida, Carolina C Souza, Maria N Melo, Sebastião A Pinto, Valeria B Quixabeira, Ledice I Pereira, Miriam L Dorta, Fatima Ribeiro-Dias, Fernando T Silveira, Sydnei M Silva, Celia M Gontijo, Wagner L Tafuri
American tegumentary leishmaniasis (ATL) is a neglected disease widely distributed in Latin America. In Brazil, it is caused by different Leishmania species belonging to the Subgenera Viannia and Leishmania. ATL diagnosis is routinely based on clinical, epidemiological, parasitological and immunological (delayed-type hypersensitivity skin test-DTH) evidences. The main objective of this work was to determine the efficacy of a previous immunohistochemical (IHC) method developed by our group. Seventy eight skin biopsies from patients with different ATL clinical forms and origins were evaluated...
October 8, 2016: Parasitology International
https://www.readbyqxmd.com/read/27717404/composition-and-cytotoxic-and-antioxidant-activities-of-the-oil-of-piper-aequale-vahl
#19
Joyce Kelly R da Silva, Laine C Pinto, Rommel M R Burbano, Raquel C Montenegro, Eloísa Helena A Andrade, José Guilherme S Maia
BACKGROUND: Piper aequale Vahl is a small shrub that grows in the shadow of large trees in the Carajás National Forest, Municipality of Parauapebas, Para state, Brazil. The local people have used the plant against rheumatism and inflammation. METHODS: The essential oil of the aerial parts was extracted and analyzed by GC and GC-MS. The MTT colorimetric assay was used to measuring the cytotoxic activity of the oil against human cancer lines. The determination of antioxidant activity of the oil was conducted by DPPH radical scavenging assay...
October 7, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27713990/intake-of-cookies-made-with-buriti-oil-mauritia-flexuosa-improves-vitamin-a-status-and-lipid-profiles-in-young-rats
#20
Jailane de Souza Aquino, Maria Helena de Araújo Vasconcelos, Débora Catarine Nepomuceno de Pontes Pessoa, Juliana Késsia Barbosa Soares, João Paulo de Sousa Prado, Robson de Jesus Mascarenhas, Marciane Magnani, Tânia Lúcia Montenegro Stamford
The oil extracted from Mauritia flexuosa (buriti) is rich in vitamin A, tocopherols and unsaturated fatty acids. This study evaluated the retinol status, blood glucose levels, lipid profiles, food efficiency rates (FERs), food conversion rates (FCRs) and murine anthropometric parameters of Wistar rats fed cookies made with buriti oil (BOC). The content of β-carotene and monounsaturated fatty acids in the cookies was enhanced (p < 0.05) using buriti oil. Rats fed BOC showed an increase (p < 0.05) in serum and hepatic retinol levels compared to rats fed cookies made with soy oil (SOC - control)...
October 12, 2016: Food & Function
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