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https://www.readbyqxmd.com/read/29777975/geriatric-analysis-from-prodige-20-randomized-phase-ii-trial-evaluating-bevacizumab-chemotherapy-versus-chemotherapy-alone-in-older-patients-with-untreated-metastatic-colorectal-cancer
#1
T Aparicio, O Bouché, E Francois, F Retornaz, E Barbier, J Taieb, S Kirscher, P-L Etienne, R Faroux, F Khemissa Akouz, F El Hajbi, C Locher, Y Rinaldi, T Lecomte, S Lavau-Denes, M Baconnier, A Oden-Gangloff, D Genet, L Bedenne, E Paillaud
BACKGROUND: Older patients have frailty characteristics that impair the transposition of treatment results found in younger patients. Predictive factors are needed to help with treatment choices for older patients. The PRODIGE 20 study is a randomized phase II study that evaluated chemotherapy associated with bevacizumab (BEV) or not (CT) in patients aged 75 years or older. PATIENTS AND METHODS: Patients underwent a geriatric assessment at randomization and at each evaluation...
May 16, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29775978/-initiating-a-robotic-program-for-abdominal-surgery-experiences-from-a-centre-in-germany
#2
Maximilian Brunner, Klaus Matzel, Archil Aladashvili, Christian Krautz, Robert Grützmann, Roland Croner
PURPOSE: Robotic systems are becoming increasingly important in abdominal surgery. We describe the implementation of a robotic program at a German centre for abdominal surgery, with focus on feasibility, safety, patient selection, learning curves, financial aspects and the lessons learned. METHODS: This retrospective analysis covered data on patient demographics, intra- and postoperative parameters, oncological results and costs of all robotic-assisted abdominal operations performed at our institution between August 2012 to December 2016...
May 18, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29770881/robot-assisted-laparoscopic-resection-of-clinical-t4b-tumours-of-distal-sigmoid-and-rectum-initial-results
#3
Rogier M P H Crolla, Janneke J C Tersteeg, George P van der Schelling, Jan H Wijsman, Jennifer M J Schreinemakers
BACKGROUND: Radical resection by multivisceral resection of colorectal T4 tumours is important to reduce local recurrence and improve survival. Oncological safety of laparoscopic resection of T4 tumours is controversial. However, robot-assisted resections might have advantages, such as 3D view and greater range of motion of instruments. The aim of this study is to evaluate the initial results of robot-assisted resection of T4 rectal and distal sigmoid tumours. METHODS: This is a cohort study of a prospectively kept database of all robot-assisted rectal and sigmoid resections between 2012 and 2017...
May 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29765794/femoral-access-for-central-venous-port-system-implantation
#4
Mikhail Cherkashin, Natalia Berezina, Denis Puchkov, Kirill Suprun, Petr Yablonsky
Totally implanted venous access port (TIVAP) systems provide adequate quality of care and life, especially for oncology patients. Long-term vascular access is very important and easy to perform, but in some clinical situations, if patients have a superior caval system occlusion, femoral insertion may be the only option. We present a case of a 70-year-old colorectal adenocarcinoma patient diagnosed with subclavian vein hypoplasia. Her care team decided intraoperatively to implant a port system by the right femoral access...
March 14, 2018: Curēus
https://www.readbyqxmd.com/read/29764494/precision-medicine-becomes-reality-tumor-type-agnostic-therapy
#5
REVIEW
Li Yan, Wei Zhang
Precision medicine just witnessed two breakthroughs in oncology in 2017. Pembrolizumab (Keytruda), Merck's anti-programmed cell death-1 (PD-1) monoclonal antibody (mAb), received accelerated approval in May 2017 by the US Food and Drug Administration for the treatment of adult and pediatric patients with unresectable or metastatic solid tumors that have been identified as having microsatellite instability-high (MSI-H) or deficient DNA mismatch repair (dMMR). Shortly after, nivolumab (Opdivo), Bristol-Myers Squibb's anti-PD-1 mAb, gained an accelerated approval in August 2017 for adult and pediatric patients with MSI-H or dMMR metastatic colorectal cancer that has progressed after standard chemotherapy...
March 31, 2018: Cancer communications
https://www.readbyqxmd.com/read/29764162/the-evolving-role-of-immune-oncology-in-colorectal-cancer
#6
Shaheenah Dawood
Metastatic colorectal cancer still remains an essentially non curable disease. However, with advances in chemotherapeutic and personalizing therapeutic approaches with the incorporation of targeted therapy such as anti-EGFR and anti-VEGF agents survival associated with metastatic colorectal cancer has certainly improved over the last two decades. Patients who are not amenable to surgery median survival remain approximately 2 to 3 years. In an attempt to improve prognostic outcome over the last decade research has focused on therapeutic options geared towards harnessing the immune system with success observed with the use of immune checkpoint inhibitors in the realm of a number of solid tumors including lung and renal cancer...
April 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29761898/clinical-impact-of-muscle-quantity-and-quality-in-colorectal-cancer-patients-a-propensity-score-matching-analysis
#7
Yoshinaga Okugawa, Yuji Toiyama, Akira Yamamoto, Tsunehiko Shigemori, Chengzeng Yin, Aya Narumi, Yusuke Omura, Shozo Ide, Takahito Kitajima, Hiroyuki Fujikawa, Hiromi Yasuda, Junichiro Hiro, Shigeyuki Yoshiyama, Minako Kobayashi, Toshimitsu Araki, Donald C McMillan, Chikao Miki, Masato Kusunoki
BACKGROUND: Sarcopenia is defined as the loss of skeletal muscle mass, accompanied by decreased muscle strength, and consists of myopenia and myosteatosis. Recent evidence has suggested the predictive value of sarcopenia for the risk of perioperative and oncological outcomes in various malignancies. The aim of this study was to clarify the clinical impact of myopenia and myosteatosis in colorectal cancer (CRC) patients. METHODS: We analyzed the preoperative psoas muscle mass index and intramuscular adipose tissue content using preoperative computed tomography images from 308 CRC patients using statistical methods...
May 15, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29756355/development-and-validation-of-a-high-quality-composite-real-world-mortality-endpoint
#8
Melissa D Curtis, Sandra D Griffith, Melisa Tucker, Michael D Taylor, William B Capra, Gillis Carrigan, Ben Holzman, Aracelis Z Torres, Paul You, Brandon Arnieri, Amy P Abernethy
OBJECTIVE: To create a high-quality electronic health record (EHR)-derived mortality dataset for retrospective and prospective real-world evidence generation. DATA SOURCES/STUDY SETTING: Oncology EHR data, supplemented with external commercial and US Social Security Death Index data, benchmarked to the National Death Index (NDI). STUDY DESIGN: We developed a recent, linkable, high-quality mortality variable amalgamated from multiple data sources to supplement EHR data, benchmarked against the highest completeness U...
May 14, 2018: Health Services Research
https://www.readbyqxmd.com/read/29755780/appendiceal-diverticulosis-a-harbinger-of-underlying-primary-appendiceal-adenocarcinoma
#9
Jia Lin Ng, Shing Lih Wong, Ronnie Mathew
Diagnosis of primary appendiceal adenocarcinoma (PAA) is hindered by its rarity and largely asymptomatic nature. Appendiceal diverticulosis (AD) is equally rare. We report an unusual case of PAA presenting with perforated appendiceal diverticulitis, and discuss a review of the literature about its association, and its surgical and pathological implications. A middle-aged man was admitted with right iliac fossa (RIF) pain and a corresponding tender abdominal mass for 5 days. Computerised tomography (CT) scan demonstrated a thickened appendix with 3 cm abscess at its base...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755777/management-of-locally-advanced-rectal-cancer-in-the-elderly-a-critical-review-and-algorithm
#10
REVIEW
Lara Hathout, Nell Maloney-Patel, Usha Malhotra, Shang-Jui Wang, Sita Chokhavatia, Ishita Dalal, Elizabeth Poplin, Salma K Jabbour
Colorectal cancer incidence and death rates have been declining over the past 10 years. However, it remains the second leading cause of death in men ages 60-79 and the third leading cause of death in men over 80 and in women over 60 years old. However, there is little data specific to the treatment of the elder patient, since few of these patients are included in trials. With the advent of improved therapies, there are many alternative options available. Still, no definitive consensus or guidelines have been defined for this particular patient population...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755762/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-ovarian-and-gastrointestinal-peritoneal-carcinomatosis-results-from-a-7-year-experience
#11
Giulia Montori, Federico Coccolini, Paola Fugazzola, Marco Ceresoli, Matteo Tomasoni, Carolina Rubicondo, Stefano Raimondo, Domenico Pinelli, Michele Colledan, Luigi Frigerio, Luca Ansaloni
Background: An increasing promising evidence and increasing long-term oncologic outcomes support the use of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as locoregional treatment for peritoneal carcinosis (PC) especially from ovarian and gastrointestinal tumors, but also for others cancers. Methods: A prospective monocentric study was performed in Papa Giovanni XXIII Hospital, Bergamo (Italy). Patients and tumor characteristics were analyzed...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29752847/an-interpretative-phenomenological-analysis-of-the-experience-of-living-with-colorectal-cancer-as-a-chronic-illness
#12
Grant J McGeechan, Kerri E McPherson, Karen Roberts
AIMS AND OBJECTIVES: The main aim of this study was to explore the lived experiences of patients living with cancer as a chronic illness. BACKGROUND: Due to recent advances in detection and treatment, cancer is now regarded as a chronic illness. However, living with cancer as a chronic illness can lead to a number of physical and psychosocial consequences all of which can lead to uncertainty over how patients view and plan for their future. DESIGN: A longitudinal qualitative study...
May 12, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29746337/bowel-obstruction-and-ventral-hernia-after-laparoscopic-versus-open-surgery-for-rectal-cancer-in-a-randomized-trial-color-ii
#13
Josefin Petersson, Thomas W Koedam, H Jaap Bonjer, John Andersson, Eva Angenete, David Bock, Miguel A Cuesta, Charlotte L Deijen, Alois Fürst, Antonio M Lacy, Jacob Rosenberg, Eva Haglind
OBJECTIVE: The aim of this study was to evaluate the risk of bowel obstruction, incisional, and parastomal hernia following laparoscopic versus open surgery for rectal cancer. SUMMARY BACKGROUND DATA: Laparoscopic surgery for rectal cancer has been adopted worldwide, after trials reported similar oncological outcomes compared with open surgery. Little is known about long-term morbidity, including bowel obstruction, incisional, and parastomal hernia following surgery...
May 9, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29744337/monosegment-alpps-hepatectomy-preserving-segment-4-for-colorectal-liver-metastases-literature-review-and-our-experience
#14
Fiammetta Soggiu, Francesco Giovinazzo, Jack Straiton, Giulia Turri, Jim Phillips, Bassam Al-Kari, Irfan Ahmed, Mohammad Habib
Monosegment 4±1 Associating Liver Partition and Portal Vein ligation for Staged hepatectomy (ALPPS) for bilateral colorectal liver metastases decreases the risk of drop-out of two stage hepatectomy, triggering a rapid and significant increase in future liver remnant (FLR) with promising oncological outcomes. We report two cases of segment 4+1 monosegment ALPPS for multiple colorectal liver metastases performed at our institution. In the literature, seven similar cases have been reported. Short and long term outcomes of our two patients were reported along with a review of data from the literature...
April 2018: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29742088/highlights-in-metastatic-colorectal-cancer-from-the-2018-american-society-of-clinical-oncology-gastrointestinal-cancers-symposium-commentary
#15
Axel Grothey
No abstract text is available yet for this article.
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29742087/highlights-in-metastatic-colorectal-cancer-from-the-2018-american-society-of-clinical-oncology-gastrointestinal-cancers-symposium
#16
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/29739893/trifluridine-tipiracil-tas-102-in-refractory-metastatic-colorectal-cancer-a-multicenter-register-in-the-frame-of-the-italian-compassionate-use-program
#17
Chiara Cremolini, Daniele Rossini, Erika Martinelli, Filippo Pietrantonio, Sara Lonardi, Silvia Noventa, Emiliano Tamburini, Giovanni Luca Frassineti, Stefania Mosconi, Federico Nichetti, Sabina Murgioni, Teresa Troiani, Beatrice Borelli, Gemma Zucchelli, Alessandro Dal Maso, Vincenzo Sforza, Gianluca Masi, Carlotta Antoniotti, Maria Di Bartolomeo, Rosalba Miceli, Fortunato Ciardiello, Alfredo Falcone
BACKGROUND: TAS-102 is indicated for patients with metastatic colorectal cancer (mCRC) previously treated with, or not considered candidates for, available therapies. Given the complete inefficacy in half of patients, the lack of predictive factors, the palliative setting, and the financial and clinical toxicity, optimizing the cost-benefit ratio is crucial. The "ColonLife" nomogram allows an estimate of the 12-week life expectancy of patients with refractory mCRC. MATERIALS AND METHODS: We collected data from patients treated at eight Italian centers in the compassionate use program...
May 8, 2018: Oncologist
https://www.readbyqxmd.com/read/29739108/using-blood-and-plasma-micrornas-as-a-non-invasive-biomarker-in-patients-with-colorectal-cancer
#18
Horatiu Stefanescu, Delia Muntean, Ciprian Pilut, Mircea Diaconu, Roxana Popescu, Delia Hutanu, Marius Moise, Lighezan Diana, Razvan Nitu, Alina Popa Cherecheanu, Silvius Negoita, Ciprian V Iovan, Emil Ungureanu, Valentin Calu, Ioana Ciuca
BACKGROUND: A high percentage of oncological patients die yearly because of colorectal cancer (CRC). Worldwide, CRC represents the fourth leading cause of death among oncological patients. Numerous studies have been conducted in order to identify new biomarkers for the early diagnosis of patients with CRC. From this point of view, an ideal biomarker is represented by the expression of microRNAs. In this paper, we wish to summarize the expressions of microRNAs in CRC and to present the pathophysiological and genetic interactions that microRNAs have with protein systems in these patients...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29730943/-the-occurrence-and-impact-on-survival-of-type-2-diabetes-mellitus-and-thrombocytosis-in-colorectal-cancer-before-and-after-the-surgical-resection-of-the-primary-tumor
#19
Zoltán Herold, Viktória Ambrus, Magdolna Herold, György Herczeg, Péter Igaz, László Harsányi, Anikó Somogyi
INTRODUCTION: The relationship between platelets and metastatic tumor cells is an ongoing research area. Pre- and postoperative thrombocytosis are suggested predictive survival markers. Colorectal cancer and type 2 diabetes are characterized by various changes to platelets. The occurrence of colorectal cancer is more frequent in diabetes. AIM: Our aim was to determine the occurrence of type 2 diabetes in colorectal cancer patients, who attended the Semmelweis University 2nd Department of Internal Medicine's Oncology Department in the last three years...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29728843/advanced-imaging-and-hospice-use-in-end-of-life-cancer-care
#20
Michaela A Dinan, Lesley H Curtis, Soko Setoguchi, Winson Y Cheung
INTRODUCTION: Advanced imaging can inform prognosis and may be a mechanism to de-escalate unnecessary end-of-life care in patients with cancer. Associations between greater use of advanced imaging and less-aggressive end-of-life care in real-world practice has not been examined. METHODS: We conducted a retrospective analysis of SEER-Medicare data on patients who died from breast, lung, colorectal, or prostate cancer between 2002 and 2007. Hospital referral region (HRR)-level use of computerized tomography (CT), magnetic resonance imaging, and positron emission tomography was categorized by tertile of imaging use and correlated with hospice enrollment overall and late hospice enrollment using multivariable logistic regression...
May 4, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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