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https://www.readbyqxmd.com/read/28917668/gut-microbe-mediated-suppression-of-inflammation-associated-colon-carcinogenesis-by-luminal-histamine-production
#1
Chunxu Gao, Bhanu Priya Ganesh, Zhongcheng Shi, Rajesh Rasik Shah, Robert Fultz, Angela Major, Susan Venable, Monica Lugo, Kathleen Hoch, Xiaowei Chen, Anthony Haag, Timothy C Wang, James Versalovic
Microbiome-mediated suppression of carcinogenesis may open new avenues for identification of therapeutic targets and prevention strategies in oncology. Histidine decarboxylase (HDC) deficiency has been shown to promote inflammation-associated colorectal cancer by accumulation of CD11b(+)Gr-1(+) immature myeloid cells, indicating a potential antitumorigenic effect of histamine. Here, we demonstrate that administration of hdc(+)Lactobacillus reuteri in the gut resulted in luminal hdc gene expression and histamine production in the intestines of Hdc(-/-) mice...
September 6, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28917012/operative-and-short-term-oncologic-outcomes-of-laparoscopic-versus-open-liver-resection-for-colorectal-liver-metastases-located-in-the-posterosuperior-liver-a-propensity-score-matching-analysis
#2
Masayuki Okuno, Claire Goumard, Takashi Mizuno, Kiyohiko Omichi, Ching-Wei D Tzeng, Yun Shin Chun, Thomas A Aloia, Jason B Fleming, Jeffrey E Lee, Jean-Nicolas Vauthey, Claudius Conrad
BACKGROUND: Laparoscopic resection (LLR) of colorectal liver metastases (CRLM) located in the posterosuperior liver (segments 4a, 7, and 8) is challenging but has become more practical recently due to progress in operative techniques. We aimed to compare tumor-specific, perioperative, and short-term oncological outcomes after LLR and open liver resection (OLR) for CRLM. METHODS: Patients who underwent curative resection of CRLM with at least 1 tumor in the posterosuperior liver during 2012-2015 were analyzed...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916945/simvastatin-enhances-radiation-sensitivity-of-colorectal-cancer-cells
#3
Georgios Karagkounis, Jennifer DeVecchio, Sylvain Ferrandon, Matthew F Kalady
INTRODUCTION: Neoadjuvant chemoradiation (CRT) for rectal cancer induces variable responses, and better response has been associated with improved oncologic outcomes. Our group has previously shown that the administration of HMG-CoA reductase inhibitors, commonly known as statins, is associated with improved response to neoadjuvant CRT in rectal cancer patients. The purpose of this study was to study the effects of simvastatin on colorectal cancer cells and explore its potential as a radiation-sensitizer in vitro...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916858/an-endoscopic-mucosal-grading-system-is-predictive-of-leak-in-stapled-rectal-anastomoses
#4
Sarath Sujatha-Bhaskar, Mehraneh D Jafari, Mark Hanna, Christina Y Koh, Colette S Inaba, Steven D Mills, Joseph C Carmichael, Ninh T Nguyen, Michael J Stamos, Alessio Pigazzi
BACKGROUND: Anastomotic leak is a devastating postoperative complication following rectal anastomoses associated with significant clinical and oncological implications. As a result, there is a need for novel intraoperative methods that will help predict anastomotic leak. METHODS: From 2011 to 2014, patient undergoing rectal anastomoses by colorectal surgeons at our institution underwent prospective application of intraoperative flexible endoscopy with mucosal grading...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28915933/mir-1290-contributes-to-colorectal-cancer-cell-proliferation-by-targeting-inpp4b
#5
Qingzhu Ma, Yan Wang, Hualing Zhang, Fengqiang Wang
Colorectal cancer (CRC) is one of the most common oncological conditions s worldwide, to date, MicroRNA 1290 (miRNA) has been demonstrated to regulate its progression. We studied the role of miR-1290 in CRC progression. The gene was upregulated in CRC tissues and cells, its overexpression promoted CRC cell proliferation analyzed by MTT assay, colony formation assay and soft agar growth assay. IN addition, miR-1290 knockdown inhibited CRC cell proliferation. We also found that miR-1290 overexpression reduced p27 level and increased Cyclin D1 level both in mRNA and protein levels, while miR-1290 knockdown increased p27 and reduced Cyclin D1 (confirming miR-1290 promoted CRC cell proliferation)...
September 15, 2017: Oncology Research
https://www.readbyqxmd.com/read/28914772/the-heat-stable-enterotoxin-receptor-guanylyl-cyclase-c-as-a-pharmacological-target-in-colorectal-cancer-immunotherapy-a-bench-to-bedside-current-report
#6
REVIEW
Trevor R Baybutt, Allison A Aka, Adam E Snook
Cancer immunotherapy is becoming a routine treatment modality in the oncology clinic, in spite of the fact that it is a relatively nascent field. The challenge in developing effective immunotherapeutics is the identification of target molecules that promote anti-tumor efficacy across the patient population while sparing healthy tissue from damaging autoimmunity. The intestinally restricted receptor guanylyl cyclase C (GUCY2C) is a target that has been investigated for the treatment of colorectal cancer and numerous animal, and clinical studies have demonstrated both efficacy and safety...
September 15, 2017: Toxins
https://www.readbyqxmd.com/read/28912926/a-rare-case-of-atrial-metastasis-from-a-rectal-adenocarcinoma
#7
Srinivas S Ayyala, Dawnette M Urcuyo, Paul T Kannarkatt, James E Kovacs, Nicole J Terrigno
Colorectal cancers typically metastasize to the lymph nodes, liver or lungs. Metastasis to the heart is rare and although a few cases of cardiac metastases from colon cancer are described in the literature, cases of metastatic rectal cancer to the heart are far fewer. A 69-year-old woman with a history of rectal adenocarcinoma treated with neo-adjuvant chemotherapy and radiation, followed by resection and adjuvant chemotherapy, presented with increasing dyspnea on exertion and lower extremity edema 5 years after oncology follow-up...
October 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28905524/first-experience-in-colorectal-surgery-with-a-new-robotic-platform-with-haptic-feedback
#8
Antonino Spinelli, Giulia David, Stefano Gidaro, Michele Carvello, Matteo Sacchi, Marco Montorsi, Isacco Montroni
The use of robotic techniques is increasing in colorectal surgery. Recently, the Senhance(™) surgical robotic system was introduced as a novel robotic platform designed to overcome some of the limits of standard laparoscopy. This study describes the initial, single center experience, evaluating feasibility and safety of the new robotic system in performing colorectal surgical procedures. METHODS: From June 2015 to November 2016, perioperative data of the first 45 patients who underwent robotic colorectal surgery with the SenhanceTM surgical robotic system were collected and analyzed...
September 14, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28905105/diagnostic-and-prognostic-role-of-18-fdg-pet-ct-in-the-management-of-resectable-biliary-tract-cancer
#9
Ka Wing Ma, Tan To Cheung, Wong Hoi She, Kenneth Siu Ho Chok, Albert Chi Yan Chan, Wing Chiu Dai, Wan Hang Chiu, Chung Mau Lo
OBJECTIVES: Role of 18-FDG PET/CT had been well established in other more prevalent malignancies such as colorectal and lung cancer; however, this is not as well defined in cholangiocarcinoma. Literature focusing on the prognostic values of preoperative PET/CT for resectable cholangiocarcinoma is scarce. METHOD: This is a retrospective cohort of 66 consecutive patients who had received curative resection for cholangiocarcinoma from 2010 to 2015. All patients had preoperative 18-FDG PET/CT performed...
September 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28904173/impact-of-metastasectomy-in-the-multimodality-approach-for-braf-v600e-metastatic-colorectal-cancer-the-mayo-clinic-experience
#10
Benny Johnson, Zhaohui Jin, Mark J Truty, Rory L Smoot, David M Nagorney, Michael L Kendrick, Benjamin R Kipp, Axel Grothey
BACKGROUND: BRAF V600E mutations are present in 8%-10% of patients with metastatic colorectal cancer (mCRC) and portend poor prognosis. This study investigated the impact of metastasectomy for patients with BRAF V600E mCRC. Subjects, Materials, and Methods . Using prospective clinical and molecular data, patients with BRAF V600E mCRC were analyzed for clinical characteristics and survival. Statistical analyses utilized the Kaplan-Meier method, log-rank test, and Cox proportional hazard models...
September 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28903424/identification-and-characterization-of-a-novel-scyl3-ntrk1-rearrangement-in-a-colorectal-cancer-patient
#11
Massimo Milione, Elena Ardini, Jason Christiansen, Emanuele Valtorta, Silvio Veronese, Roberta Bosotti, Alessio Pellegrinelli, Adele Testi, Filippo Pietrantonio, Giovanni Fucà, Ge Wei, Danielle Murphy, Salvatore Siena, Antonella Isacchi, Filippo De Braud
In colorectal cancer patients, chromosomal rearrangements involving NTRK1 gene (encoding the TRKA protein) are shown in a small subset of patients and are associated with the constitutive activation of the kinase domain of TRKA. In turn, activated TRKA-fusion proteins are associated with proliferation and survival in colorectal cancer tumors. Here we report the identification and functional characterization of a new SCYL3-NTRK1 fusion gene in a 61-year-old colorectal cancer patient. To our knowledge, this fusion protein has never been previously documented in oncological patients...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28895551/indocyanine-green-fluorescence-imaging-in-colorectal-surgery-overview-applications-and-future-directions
#12
REVIEW
Deborah S Keller, Takeaki Ishizawa, Richard Cohen, Manish Chand
Indocyanine green fluorescence imaging is a surgical tool with increasing applications in colorectal surgery. This tool has received acceptance in various surgical disciplines as a potential method to enhance surgical field visualisation, improve lymph node retrieval, and decrease the incidence of anastomotic leaks. In colorectal surgery specifically, small studies have shown that intraoperative fluorescence imaging is a safe and feasible method to assess anastomotic perfusion, and its use might affect the incidence of anastomotic leaks...
October 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28895471/the-indirect-costs-of-palliative-care-in-end-stage-cancer-a-real-life-longitudinal-register-and-questionnaire-based-study
#13
Olli Haltia, Niilo Färkkilä, Risto Paavo Roine, Harri Sintonen, Kimmo Taari, Juha Hänninen, Juho Tuomas Lehto, Tiina Saarto
BACKGROUND: Palliative care needs are increasing as more people are dying from incurable diseases. Healthcare costs have been reported to be highest during the last year of life, but studies on the actual costs of palliative care are scarce. AIM: To explore the resource use and costs of palliative care among end-stage breast, colorectal and prostate cancer patients after termination of life-prolonging oncological treatments, that is, during the palliative care period...
September 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28895233/validation-of-the-opportunity-for-treatment-in-oncology-option-questionnaire-measuring-continuity-of-care
#14
Paola Rucci, Silvia Foglino, Francesca Bravi, Rossella D'Avenia, Mattia Altini, Tiziano Carradori, Angela Angelastro, Maria Pia Fantini
Increasing efforts are ongoing to deliver effective cancer care through integrated networks of services. Measuring patients' experience of care is essential to identify problematic areas that require organisational adjustments. The aim of the present study was to examine the validity of OPTION questionnaire, designed to measure patient's perceived continuity of care across different phases of their care pathway. The study was carried at the Institute for Cancer Treatment and Research, Meldola and the oncology departments of the Local Health Authority of Romagna, Italy...
September 11, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28894396/a-validation-of-clinical-data-captured-from-a-novel-cancer-care-quality-program-directly-integrated-with-administrative-claims-data
#15
David M Kern, John J Barron, Bingcao Wu, Alex Ganetsky, Vincent J Willey, Ralph A Quimbo, Michael J Fisch, Joseph Singer, Ann Nguyen, Ronac Mamtani
BACKGROUND: Data from a Cancer Care Quality Program are directly integrated with administrative claims data to provide a level of clinical detail not available in claims-based studies, and referred to as the HealthCore Integrated Research Environment (HIRE)-Oncology data. This study evaluated the validity of the HIRE-Oncology data compared with medical records of breast, lung, and colorectal cancer patients. METHODS: Data elements included cancer type, stage, histology (lung only), and biomarkers...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28890829/a-rare-case-of-primary-rectal-squamous-cell-carcinoma-diagnosed-by-endoscopic-ultrasound
#16
Amirali Kiyani, Walter J Coyle, Fei Bao
Primary squamous cell carcinoma (SCC) of the rectum is a very rare entity making up to 0.1-0.25/1,000 cases of all colorectal cancers. Here, we present the case of an otherwise healthy 63-year-old female who presented with progressive pelvic discomfort, new onset constipation and a complex mass in presacral region on imaging which was proved to be poorly differentiated SCC of the rectum. The correct diagnosis was achieved by fine needle aspiration (FNA) via endoscopic ultrasound (EUS-guided FNA) as initial conventional colonoscopy failed to establish the diagnosis...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890671/current-management-of-peritoneal-carcinomatosis-from-colorectal-cancer-the-role-of-cytoreductive-surgery-and-hyperthermic-peritoneal-chemoperfusion
#17
Ibrahim Nassour, Patricio M Polanco
Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is a disease with a poor prognosis, often thought to be a terminal illness with no hope except for palliative treatment. New therapeutic modalities combining cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have shown favorable outcomes and may provide a significant survival benefit in a selected group of patients. The main rational for CRS is to remove all visible tumor burden to allow for the chemotherapeutic agent (HIPEC) to eradicate any microscopic residual disease...
April 2017: Current Colorectal Cancer Reports
https://www.readbyqxmd.com/read/28881641/colorectal-cancer-at-high-risk-of-peritoneal-metastases-long-term-outcomes-of-a-pilot-study-on-adjuvant-laparoscopic-hipec-and-future-perspectives
#18
Charlotte E L Klaver, Roos Stam, Didi A M Sloothaak, Johannes Crezee, Willem A Bemelman, Cornelis J A Punt, Pieter J Tanis
OBJECTIVE: Early detection of peritoneal metastases (PM) of colorectal cancer (CRC) is difficult and treatment options at a clinically overt stage are limited. Potentially, adjuvant laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) is of value. The aim of this study was to present long term oncological outcomes of a pilot study on adjuvant HIPEC to reduce development of PMCRC, with systematic review of literature. METHODS: Long term oncological outcomes of ten patients who underwent laparoscopic HIPEC within eight weeks after resection of primary CRC in the pilot study were retrospectively collected...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28877856/geriatric-cancer-trends-in-the-middle-east-findings-from-lebanese-cancer-projections-until-2025
#19
Fady G H Haddad, Joseph Kattan, Hampig R Kourie, Elie El Rassy, Tarek Assi, Salim M Adib
OBJECTIVE: By 2020, 70% of all cancers will occur in patients aged 65years and older, causing an increase in related morbidity, mortality, and cost. This study projects cancer trends in the elderly population in Lebanon, a country experiencing accelerating aging trends. Findings will guide future policy decisions regarding geriatric oncology in Lebanon and the surrounding Arab world. MATERIALS AND METHODS: Cancer incidence rates were derived for men and women 65years and above, divided into three age groups: 65-69years, 70-74years, and 75years and above...
September 4, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28876649/an-evaluation-of-epidemiological-differences-in-colorectal-cancer-patients-over-and-under-the-age-of-50-presenting-to-academic-centers-in-johannesburg
#20
B D Bebington
BACKGROUND: As in other developing countries, the nations of Sub-Saharan Africa have seen an increase in the incidence of colorectal cancer. Repeatedly, the indigenous populations have shown a skewing of incidence in favour of patients below the age of 50. As part of a larger study, and through funding from the Medical research Council of South Africa, the Wits MRC Oncology group has set out to identify the epidemiological characteristics and disease progression of patients under the age of 50 presenting with colorectal cancer...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
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