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https://www.readbyqxmd.com/read/28432944/phototoxic-action-of-a-zinc-ii-phthalocyanine-encapsulated-into-poloxamine-polymeric-micelles-in-2d-and-3d-colon-carcinoma-cell-cultures
#1
Nicolás Chiarante, María C García Vior, Josefina Awruch, Julieta Marino, Leonor P Roguin
Photodynamic therapy is emerging as a hopeful method for the treatment of oncological diseases. In the search of novel therapeutic strategies for colorectal cancer, in this work we reported the photocytotoxic activity of a lipophilic zinc(II) phthalocyanine on a murine colon adenocarcinoma cell line (CT26 cells). The 2,9(10),16(17),23(24) tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II), named Pc9, was encapsulated into Tetronic® 1107 polymeric poloxamine micelles (T1107) and assayed in 2D and 3D cell cultures...
April 11, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28432295/laparoscopic-versus-open-liver-resection-for-colorectal-liver-metastases-a-comprehensive-systematic-review-and-meta-analysis
#2
Si-Ming Xie, Jun-Jie Xiong, Xue-Ting Liu, Hong-Yu Chen, Daniel Iglesia-García, Kiran Altaf, Shameena Bharucha, Wei Huang, Quentin M Nunes, Peter Szatmary, Xu-Bao Liu
The effects of laparoscopic liver resection (LLR) and open liver resection (OLR) on oncological outcomes for colorectal cancer liver metastases (CCLM) remain inconclusive. Major databases were searched from January 1992 to October 2016. Effects of LLR vs OLR were determined. The primary endpoints were oncological outcomes. In total, 32 eligible non-randomized studies with 4697 patients (LLR: 1809, OLR: 2888) were analyzed. There were higher rates of clear surgical margins (OR: 1.64, 95%CI: 1.32 to 2.05, p < 0...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427281/the-servier-oncology-pipeline-in-2017
#3
Patrick Therasse, Beatrice Perron, Sarah A Novack, Jean-Pierre Abastado
Cancer is a complex, multifactorial disease that for years has been the focus of intensive research efforts to explore both the molecular and biological mechanisms involved and the development of novel agents to target these pathways. Servier is an independent French pharmaceutical company with a focus on oncology. Currently, Servier's commercial portfolio includes agents used to treat non-Hodgkin's lymphoma and metastatic colorectal cancer; Servier's oncology pipeline involves agents for the treatment of both solid and hematological tumors...
April 21, 2017: Future Oncology
https://www.readbyqxmd.com/read/28423789/using-electronic-health-records-to-assess-depression-and-cancer-comorbidities
#4
Miguel A Mayer, Alba Gutierrez-Sacristan, Angela Leis, Santiago De La Peña, Ferran Sanz, Laura I Furlong
Comorbid diseases are an important concern in oncology since they can affect the choice and effectiveness of treatment. What is particularly relevant is the fact that the diagnosis of depression in cancer patients has an important impact on the quality of life of these patients. Although there is no consensus about a specific relationship of depression with certain cancer types, some authors have proposed that depression constitutes a risk factor for cancer. The objective of this study is to identify the presence of comorbidities in a massive EHR system, between depression and the 10 most common cancers in women and men and to determine if there is a preferred temporal ordering in the co-occurrence of these diseases...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28418371/-intersphincteric-resection-for-stage-i-iii-low-rectal-cancer-is-an-oncologically-safe-alternative-to-extralevator-abdomino-perineal-rectal-resection
#5
I A Tulina, M I Bredikhin, A N Gerasimov, N N Krylov, I V Reshetov, P V Tsarkov
AIM: To compare oncologic efficiency of intersphincteric resections and extralevator abdominoperineal excisions in surgical treatment of low rectal cancer. METHODS: Between 2006 and 2015 in Department of colorectal and pelvic floor surgery (Russian scientific center of surgery n.a. acad. B.V. Petrovsky) and in Clinic of Colorectal and Minimally invasive surgery (Sechenov First Moscow State Medical University) 40 consecutive patients underwent intersphincteric resection (ISR) and 31 underwent extralevator abdominoperineal excision (EAPE)...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28410243/impact-of-perioperative-blood-transfusion-on-clinical-outcomes-in-patients-with-colorectal-liver-metastasis-after-hepatectomy-a-meta-analysis
#6
Xinghua Lyu, Wenhui Qiao, Debang Li, Yufang Leng
BACKGROUND: Perioperative blood transfusion may be associated with negative clinical outcomes in oncological surgery. A meta-analysis of published studies was conducted to evaluate the impact of blood transfusion on short- and long-term outcomes following liver resection of colorectal liver metastasis (CLM). MATERIALS AND METHODS: A systematic search was performed to identify relevant articles. Data were pooled for meta-analysis using Review Manager version 5.3...
March 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28408840/clinical-course-and-outcome-of-patients-with-high-level-microsatellite-instability-cancers-in-a-real-life-setting-a-retrospective-analysis
#7
Naama Halpern, Yael Goldberg, Luna Kadouri, Morasha Duvdevani, Tamar Hamburger, Tamar Peretz, Ayala Hubert
BACKGROUND: The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS: A retrospective analysis of MSI-H cancer patient files was conducted. We analyzed the genetic data, clinical characteristics, and oncological treatments, including chemotherapy and surgical interventions...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28407227/systematic-review-of-pressurized-intraperitoneal-aerosol-chemotherapy-for-the-treatment-of-advanced-peritoneal-carcinomatosis
#8
REVIEW
F Grass, A Vuagniaux, H Teixeira-Farinha, K Lehmann, N Demartines, M Hübner
BACKGROUND: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a minimally invasive approach under investigation as a novel treatment for patients with peritoneal carcinomatosis of various origins. The aim was to review the available evidence on mechanisms, clinical effects and risks. METHODS: This was a systematic review of the literature on pressurized intraperitoneal chemotherapy published between January 2000 and October 2016. All types of scientific report were included...
May 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28401350/peritoneal-fluid-biomarkers-in-the-detection-of-colorectal-anastomotic-leaks-a-systematic-review
#9
REVIEW
Emma C Wright, Patricia Connolly, Mark Vella, Susan Moug
PURPOSE: Anastomotic leak (AL) in colorectal surgery leads to significant morbidity, mortality and poorer oncological outcomes. Diagnosis of AL is frequently delayed as current methods of detection are not 100% sensitive or specific. 'Biomarkers', such as cytokines and markers of ischaemia, from the milieu of the anastomosis may aid early detection. This paper aims to review the evidence for their role in AL detection, allowing identification of targets for future research. METHODS: A systematic review was performed using PubMed, MEDLINE and Cochrane Library databases...
April 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28398493/phase-ii-trial-of-neoadjuvant-chemotherapy-with-s-1-and-oxaliplatin-plus-bevacizumab-for-colorectal-liver-metastasis-n-sog-05-trial
#10
Toshiki Mukai, Keisuke Uehara, Hidenari Goto, Kazuhiro Hiramatsu, Satoshi Kobayashi, Eiji Sakamoto, Atsuyuki Maeda, Eiji Takeuchi, Yoshito Okada, Tomoki Ebata, Masato Nagino
Purpose: This Phase II trial evaluated the safety and efficacy of neoadjuvant chemotherapy (NAC) with S-1 and oxaliplatin (SOX) plus bevacizumab (Bev) in patients with colorectal liver metastasis (CRLM). Methods: Patients with initially resectable CRLM received four cycles of SOX plus Bev as NAC. We adopted the R0 resection rate as the primary endpoint, and the threshold R0 resection rate was set at 80%. Results: Between December 2010 and August 2014, 61 patients were enrolled in this study and all started NAC...
April 7, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28393575/using-circulating-cell-free-dna-to-monitor-personalized-cancer-therapy
#11
Michael Oellerich, Ekkehard Schütz, Julia Beck, Philipp Kanzow, Piers N Plowman, Glen J Weiss, Philip D Walson
High-quality genomic analysis is critical for personalized pharmacotherapy in patients with cancer. Tumor-specific genomic alterations can be identified in cell-free DNA (cfDNA) from patient blood samples and can complement biopsies for real-time molecular monitoring of treatment, detection of recurrence, and tracking resistance. cfDNA can be especially useful when tumor tissue is unavailable or insufficient for testing. For blood-based genomic profiling, next-generation sequencing (NGS) and droplet digital PCR (ddPCR) have been successfully applied...
April 10, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/28387949/mindfulness-practice-reduces-cortisol-blunting-during-chemotherapy-a-randomized-controlled-study-of-colorectal-cancer-patients
#12
David S Black, Cheng Peng, Alix G Sleight, Nathalie Nguyen, Heinz-Josef Lenz, Jane C Figueiredo
BACKGROUND: The objective of this randomized clinical experiment was to test the influence of a mindfulness meditation practice, when delivered during 1 session of active chemotherapy administration, on the acute salivary cortisol response as a marker of neuroendocrine system activity in cancer patients. METHODS: A mindfulness, attention-control, or resting exposure was assigned to 57 English- or Spanish-speaking colorectal cancer patients at 1 county oncology clinic and 1 university oncology clinic at the start of chemotherapy...
April 7, 2017: Cancer
https://www.readbyqxmd.com/read/28384684/an-international-collaborative-standardizing-a-comprehensive-patient-centered-outcomes-measurement-set-for-colorectal-cancer
#13
Jessica A Zerillo, Maartje G Schouwenburg, Annelotte C M van Bommel, Caleb Stowell, Jacob Lippa, Donna Bauer, Ann M Berger, Gilles Boland, Josep M Borras, Mary K Buss, Robert Cima, Eric Van Cutsem, Eino B van Duyn, Samuel R G Finlayson, Skye Hung-Chun Cheng, Corinna Langelotz, John Lloyd, Andrew C Lynch, Harvey J Mamon, Pamela K McAllister, Bruce D Minsky, Joanne Ngeow, Muhammad R Abu Hassan, Kim Ryan, Veena Shankaran, Melissa P Upton, John Zalcberg, Cornelis J van de Velde, Rob Tollenaar
Importance: Global health systems are shifting toward value-based care in an effort to drive better outcomes in the setting of rising health care costs. This shift requires a common definition of value, starting with the outcomes that matter most to patients. Objective: The International Consortium for Health Outcomes Measurement (ICHOM), a nonprofit initiative, was formed to define standard sets of outcomes by medical condition. In this article, we report the efforts of ICHOM's working group in colorectal cancer...
April 6, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28383445/anorectal-function-and-quality-of-life-in-patients-with-early-stage-rectal-cancer-treated-with-chemoradiation-and-local-excision
#14
MULTICENTER STUDY
Patricio B Lynn, Lindsay A Renfro, Xiomara W Carrero, Qian Shi, Paul L Strombom, Oliver Chow, Julio Garcia-Aguilar
BACKGROUND: Little is known about anorectal function and quality of life after chemoradiation followed by local excision, which is an alternative to total mesorectal excision for selected patients with early rectal cancer. OBJECTIVE: The purpose of this study was to prospectively assess anorectal function and health-related quality of life of patients with T2N0 rectal cancer who were treated with an alternative approach. DESIGN: This was a prospective, phase II trial...
May 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28381946/combined-endoscopic-laparoscopic-surgery-procedures-for-colorectal-surgery
#15
REVIEW
Sarah B Placek, Jeffrey Nelson
Colonoscopy is the standard of care for screening and surveillance of colorectal cancers. Removal of adenomatous polyps prevents the transformation of adenomas to potential adenocarcinoma. While most polyps are amenable to simple endoscopic polypectomy, difficult polyps that are large, broad-based, or located in haustral folds or in tortuous colon segments can present a challenge for endoscopists. Traditionally, patients with endoscopically unresectable polyps have been referred for oncologic surgical resection due to the underlying risk of malignancy within the polyp; however, the majority of these polyps are benign on final pathology...
April 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/28379722/clinical-pathways-management-of-quality-and-cost-in-oncology-networks-in-the-metastatic-colorectal-cancer-setting
#16
Peter G Ellis, Bert H O'Neil, Martin F Earle, Stephanie McCutcheon, Hans Benson, Melinda Krebs, Kathy Lokay, Amanda Barry
PURPOSE: Via Pathways (clinical pathways for cancer) provide evidence-based guidance for specific patient presentations based on the merit of efficacy, then toxicity, and finally cost (if efficacy and toxicity are comparable). We evaluated the impact of a change to the guidance in the metastatic colorectal cancer (mCRC) setting across two large, integrated health networks. METHODS: Cetuximab and panitumumab were determined to have equal efficacy in the treatment of mCRC with no significant difference in toxicity based on recent data from key clinical studies...
April 5, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28368245/colorectal-cancer-a-disease-of-the-young
#17
EDITORIAL
The Lancet Oncology
No abstract text is available yet for this article.
April 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28364212/parenchymal-sparing-versus-anatomic-liver-resection-for-colorectal-liver-metastases-a-systematic-review
#18
Dimitrios Moris, Sean Ronnekleiv-Kelly, Amir A Rahnemai-Azar, Evangelos Felekouras, Mary Dillhoff, Carl Schmidt, Timothy M Pawlik
INTRODUCTION: Colorectal liver metastases develop in 50% of patients diagnosed with colorectal cancer. Surgical resection for colorectal liver metastasis typically involves either anatomical resection (AR) or parenchymal-sparing hepatectomy (PSH). The objective of the current study was to analyze data on parenchymal versus non-parenchymal-sparing hepatic resections for CLM. METHODS: A systematic review of the literature regarding parenchymal-sparing hepatectomy was performed...
March 31, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28356884/predictive-value-of-carcinoembryonic-and-carbohydrate-antigen-19-9-related-to-some-clinical-endoscopic-and-histological-colorectal-cancer-characteristics
#19
Ratko Tomašević, Tomica Milosavljević, Dragoš Stojanović, Zoran Gluvić, Predrag Dugalić, Ivan Ilić, Radosav Vidaković
BACKGROUND: Colorectal cancer (CRC) is an important oncological and public health problem worldwide, including Serbia. Unfortunately, half of the patients are recognized in an advanced stage of the disease, therefore, early detection through specific tumor biomarkers, such as carcinoembryonic (CEA) and carbohydrate antigen 19-9 (CA 19-9), is the only way to cope with CRC expansion. METHODS: Our cross-sectional study evaluated the influence of some clinical, endoscopic and histological characteristics of CRC on CEA and CA 19-9 serum levels, to determine whether these biomarkers could be related to CRC detection...
September 2016: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28350513/molecular-biomarkers-for-the-evaluation-of-colorectal-cancer-guideline-summary-from-the-american-society-for-clinical-pathology-college-of-american-pathologists-association-for-molecular-pathology-and-american-society-of-clinical-oncology
#20
Antonia R Sepulveda, Stanley R Hamilton, Carmen J Allegra, Wayne Grody, Allison M Cushman-Vokoun, William K Funkhouser, Scott E Kopetz, Christopher Lieu, Noralane M Lindor, Bruce D Minsky, Federico A Monzon, Daniel J Sargent, Veena M Singh, Joseph Willis, Jennifer Clark, Carol Colasacco, R Bryan Rumble, Robyn Temple-Smolkin, Christina B Ventura, Jan A Nowak
No abstract text is available yet for this article.
March 28, 2017: Journal of Oncology Practice
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