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https://www.readbyqxmd.com/read/29238480/maternal-recto-vaginal-colonization-in-term-and-preterm-deliveries
#1
Mostafa Javanian, Zahra Akbarian Rad, Mohsen Haghshenas Mojaveri, Azita Ghanbarpour Shiadeh, Soheil Ebrahimpour
Background and aim: Maternal recto-vaginal organisms are the main cause of early-onset sepsis in neonates. The aim of this study was to determine the most common organisms and compare maternal recto-vaginal colonization in term and preterm delivery. Methods: This cross-sectional study was done from October 2014 through October 2016 among participants referred to Ayatollah Rouhani Hospital in Babol, Northern Iran. All pregnant women within gestational age (GA) ≥ 26 weeks and labor pain were included in this study...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29234847/correction-to-if-you-detonate-dynamite-you-should-know-your-fish
#2
Dietrich Doll
In the original article, the last paragraph erroneously states that author's upcoming study was going to be published in Diseases of the Colon and Rectum.
December 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29234589/retrospective-study-of-predictors-of-bone-metastasis-in-colorectal-cancer-patients
#3
Zhenghong, Zihua Zhu, Guoweijian, Zhangning, Caiyunyun, Yingjiangshan, Xiaomi
Background: We explored risk factors for bone metastasis (BMs) in colorectal cancer (CRC) to improve in early diagnosis and follow-up and to reduce bone metastasis. Methods: With a retrospective analysis of 2066 patients with CRC treated in our institution from January 2006 to January 2015, we assessed high-risk variables associated with bone metastasis using univariate and multivariate analyses. Results: Of those subjects studied, 102 patients developed BMs, including 62 of 1014 the rectal cancer patients and 40 of the 1052 colon cancer patients...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29233694/insight-of-nitric-oxide-signalling-a-potential-biomarker-in-bio-regulation-with-multifaceted-complex-mechanism-in-colorectal-carcinogenesis
#4
Paramita Mandal
Colorectal carcinogenesis (CRC) is the most important health concerns throughout the World as the tumour cells rapidly spread and abruptly grow in colon and rectum to further organs. Several etiological factors are associated with colorectal carcinogenesis. During invasion and proliferation of tumour cells, various mechanistic molecular pathways are involved in the cells. Nitric Oxide pathway (NO) is one of the important cellular mechanisms associated with tumour cells initiation, invasion and progression. Epidemiological evidences suggest that NO has potential role in development of cancer...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29232390/clinicopathological-hallmarks-and-biomarkers-of-colorectal-neuroendocrine-neoplasms
#5
Alexander Koenig, Sebastian Krug, Daniela Mueller, Peter J Barth, Ute Koenig, Michael Scharf, Volker Ellenrieder, Patrick Michl, Roland Moll, Kia Homayunfar, Peter Herbert Kann, Philipp Stroebel, Thomas M Gress, Anja Rinke
Chromogranin A (CgA) is a well-established marker for diagnosis and follow up of patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). Recently, it has been shown that plasma levels of CgA correlate with tumor load and predict survival of patients with NEN of the small bowel. It is assumed that this is as well valid for NEN of the colon and rectum, however, this is not supported by data. To evaluate this assumption, we analyzed 62 patients with NEN of the colon and rectum listed in the Marburg GEP-NEN registry for clinicopathological characteristics, expression and plasma levels of CgA...
2017: PloS One
https://www.readbyqxmd.com/read/29227748/survival-in-signet-ring-cell-carcinoma-varies-based-on-primary-tumor-location-a-surveillance-epidemiology-and-end-results-database-analysis
#6
San-Gang Wu, Xue-Ting Chen, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Zhen-Yu He, Xiao-Qing Pei, Qin Lin
BACKGROUND: The aim of this study was to investigate the survival of patients with signet ring cell carcinoma (SRCC) based on primary tumor location. METHODS: Patient data were obtained from the Surveillance, Epidemiology, and End Results database (1988-2012) with ≥200 cases per tumor location. Cox regression analysis was used to investigate prognostic factors of cause-specific survival (CSS). RESULTS: We identified 24,171 patients. Of the patients, 63...
December 11, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29223986/kras-testing-tumor-location-and-survival-in-patients-with-stage-iv-colorectal-cancer-seer-2010-2013
#7
Mary E Charlton, Amanda R Kahl, Alissa A Greenbaum, Jordan J Karlitz, Chi Lin, Charles F Lynch, Vivien W Chen
Purpose:KRAS mutations and tumor location have been associated with response to targeted therapy among patients with stage IV colorectal cancer (CRC) in various trials. This study performed the first population-based examination of associations between KRAS mutations, tumor location, and survival, and assessed factors associated with documented KRAS testing. Methods: Patients with stage IV adenocarcinoma of the colon/rectum diagnosed from 2010 to 2013 were extracted from SEER data. Analyses of patient characteristics, KRAS testing, and tumor location were conducted using logistic regression...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29219924/combined-laparoscopic-and-perineal-approach-to-omental-interposition-repair-of-complex-rectovaginal-fistula
#8
Hester de Bruijn, Yasuko Maeda, Jamie Murphy, Janindra Warusavitarne, Carolynne J Vaizey
INTRODUCTION: Surgical repair of rectovaginal fistula remains a challenge. Complex and recurrent rectovaginal fistula repairs often fail because of scarring and devascularization of the surrounding tissue. Omental interposition may promote healing by introducing bulky vascularized tissue into the rectovaginal septum. TECHNIQUE: With the patient in the lithotomy position, the rectovaginal septum was dissected transperineally up to the fistula tract and the openings on both vaginal and rectal sides were closed using interrupted, absorbable sutures...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29218384/is-it-possible-to-give-a-single-definition-of-the-rectosigmoid-junction
#9
Damien Massalou, David Moszkowicz, Daniela Mariage, Patrick Baqué, Olivier Camuzard, Nicolas Bronsard
AIM: The rectosigmoid junction is the limit separating the sigmoid colon and rectum. This transition zone has different definitions. We want to highlight different landmarks of the rectosigmoid junction (RSJ), to help the clinicians to adopt a consensual definition. METHOD: We reviewed anatomical, endoscopic, physiological and surgical points of view concerning the rectosigmoid junction (RSJ). RESULTS: The rectosigmoid junction has a different definition depending on who is studying it...
December 7, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29217892/bowel-migration-of-dormant-chronic-ambulatory-peritoneal-dialysis-catheter-a-vexed-problem-not-avoided-by-flushing
#10
P Vincent, J Gopinathan, R Narayanan
Delayed bowel erosion by peritoneal dialysis catheter is rare with fewer than thirty cases having been reported in the literature. This complication is usually encountered when the catheter is kept dormant. Two cases have also been reported with catheters in active use. The risk factors for bowel erosion include immunosuppression, diverticulosis, and amyloidosis. An 80-year-old male with chronic kidney disease Stage 5 due to hypertensive nephrosclerosis underwent chronic ambulatory peritoneal dialysis catheter insertion...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29216565/incidence-prevalence-mortality-disability-adjusted-life-years-and-risk-factors-of-cancer-in-australia-and-comparison-with-oecd-countries-1990-2015-findings-from-the-global-burden-of-disease-study-2015
#11
Yohannes Adama Melaku, Sarah L Appleton, Tiffany K Gill, Felix A Ogbo, Elizabeth Buckley, Zumin Shi, Tim Driscoll, Robert Adams, Benjamin C Cowie, Christina Fitzmaurice
BACKGROUND: Comparative evidence on the burden, trend, and risk factors of cancer is limited. Using data from the Global Burden of Disease (GBD) study, we aimed to assess cancer burden - incidence, prevalence, mortality, disability-adjusted life years (DALYs) - and attributable risk factors for Australia between 1990 and 2015, and to compare them with those of 34 members of the Organisation for Economic Co-operation and Development (OECD). METHODS: The general GBD cancer estimation methods were used with data input from vital registration systems and cancer registries...
December 4, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29215955/results-of-a-randomized-double-blind-placebo-controlled-phase-iii-trial-of-trifluridine-tipiracil-tas-102-monotherapy-in-asian-patients-with-previously-treated-metastatic-colorectal-cancer-the-terra-study
#12
Jianming Xu, Tae Won Kim, Lin Shen, Virote Sriuranpong, Hongming Pan, Ruihua Xu, Weijian Guo, Sae-Won Han, Tianshu Liu, Young Suk Park, Chunmei Shi, Yuxian Bai, Feng Bi, Joong Bae Ahn, Shukui Qin, Qi Li, Changping Wu, Dong Ma, Donghu Lin, Jin Li
Purpose Trifluridine/tipiracil (TAS-102) was effective in patients with metastatic colorectal cancer (mCRC) in a phase II Japanese trial. This regional trial evaluated the efficacy and safety of trifluridine/tipiracil in Asian patients with mCRC with or without exposure to biologic therapy. Patients and Methods This randomized, double-blind, placebo-controlled, phase III trial was conducted at 30 sites in China, the Republic of Korea, and Thailand. Patients ≥ 18 years old with histologically or cytologically confirmed adenocarcinoma of the colon or rectum and known KRAS status who were refractory or intolerant to two or more prior chemotherapy regimens were enrolled...
December 7, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29215476/clinical-outcomes-of-self-expandable-metal-stents-for-malignant-rectal-obstruction
#13
Hyun Jung Lee, Sung Pil Hong, Jae Hee Cheon, Tae Il Kim, Won Ho Kim, Soo Jung Park
BACKGROUND: Self-expandable metal stents are widely used to treat malignant colorectal obstruction. However, data on clinical outcomes of stent placement for rectal obstruction specifically are lacking. OBJECTIVE: We aimed to investigate the clinical outcomes of self-expandable metal stents in malignant rectal obstruction in comparison with those in left colonic obstruction and to identify factors associated with clinical failure and complication. DESIGN: This was a retrospective study...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29212105/-german-society-of-gastroenterology-digestive-and-metabolic-diseases-dgvs-position-statement-on-endoscopic-decompression-in-acute-ileus
#14
Martin Götz, Georg Braun, Ralf Jakobs, Helmut Messmann, Eduard F Stange, Markus M Lerch
In patients with ileus with dilated intestine in imaging studies, endoscopic decompression appears a feasible option. However, its use is often uncritical and without scientific evidence. Before considering endoscopic intervention, CT-imaging should differentiate between mechanical obstruction and paralytic ileus/intestinal pseudo-obstruction. Tumor diagnosis and localisation are essential because the latter determines the choice of the decompression procedure. Coecal dilatation of more than 12 cm indicates an increased risk of perforation...
December 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29210899/distinct-microbial-populations-exist-in-the-mucosa-associated-microbiota-of-diarrhea-predominant-irritable-bowel-syndrome-and-ulcerative-colitis
#15
Wenting Zhong, Xiaolan Lu, Haitao Shi, Gang Zhao, Yahua Song, Yonghua Wang, Jing Zhang, Yaofeng Jin, Shenhao Wang
GOALS: The goal of this study was to observe the bacterial colonization in the intestinal mucosa in the patients with diarrhea predominant irritable bowel syndrome (IBS-D) and ulcerative colitis (UC), and compare the mucosa-associated microbiota among the IBS-D patients, UC patients and the healthy control, and explore the correlation of the mucosa-associated microbiota with clinical manifestations. STUDY: A total of 20 IBS-D patients, 28 patients with UC (16 active, 12 inactive) and 16 healthy subjects were enrolled in the study...
November 28, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29209981/the-effect-of-frailty-index-on-early-outcomes-after-combined-colorectal-and-liver-resections
#16
Sophia Y Chen, Miloslawa Stem, Marcelo Cerullo, Susan L Gearhart, Bashar Safar, Sandy H Fang, Matthew J Weiss, Jin He, Jonathan E Efron
BACKGROUND: Although previous studies have examined frailty as a potential predictor of adverse surgical outcomes, little is reported on its application. We sought to assess the impact of the 5-item modified frailty index (mFI) on morbidity in patients undergoing combined colorectal and liver resections. METHODS: Adult patients who underwent combined colorectal and liver resections were identified using the ACS-NSQIP database (2005-2015). The 5-item mFI consists of history of chronic obstructive pulmonary disease, congestive heart failure, hypertension, diabetes, and partial/total dependence...
December 5, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29209524/heterogeneity-of-colon-cancer-from-bench-to-bedside
#17
REVIEW
Marco C Merlano, Cristina Granetto, Elena Fea, Vincenzo Ricci, Ornella Garrone
The large bowel shows biomolecular, anatomical and bacterial changes that proceed from the proximal to the distal tract. These changes account for the different behaviour of colon cancers arising from the diverse sides of the colon-rectum as well as for the sensitivity to the therapy, including immunotherapy. The gut microbiota plays an important role in the modulation of the immune response and differs between the right colon cancer and the left colorectal cancer. The qualitative and quantitative difference of the commensal bacteria between the right side and the left side induces epigenetic changes in the intestinal epithelial cells as well as in the resident immune population...
2017: ESMO Open
https://www.readbyqxmd.com/read/29208881/clinicopathological-assessment-of-colorectal-carcinoma-in-mymensingh-medical-college-hospital-bangladesh
#18
M M Mahamud, F Wahed, J Ferdous, M K Khan
Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women in the US. It is mainly a disease of the developed countries with a western culture, yet the disease is not uncommon in developing countries. There is substantial geographical variation in the incidence and demographic characteristics of the disease. Variations are also observed in the risk factors, mode of presentation, sub site distribution and stage of the disease at presentation...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29206231/cancer-type-dependent-expression-of-ck2-transcripts
#19
Melissa M J Chua, Migi Lee, Isabel Dominguez
A multitude of proteins are aberrantly expressed in cancer cells, including the oncogenic serine-threonine kinase CK2. In a previous report, we found increases in CK2 transcript expression that could explain the increased CK2 protein levels found in tumors from lung and bronchus, prostate, breast, colon and rectum, ovarian and pancreatic cancers. We also found that, contrary to the current notions about CK2, some CK2 transcripts were downregulated in several cancers. Here, we investigate all other cancers using Oncomine to determine whether they also display significant CK2 transcript dysregulation...
2017: PloS One
https://www.readbyqxmd.com/read/29205995/volume-and-health-outcomes-evidence-from-systematic-reviews-and-from-evaluation-of-italian-hospital-data
#20
Laura Amato, Danilo Fusco, Anna Acampora, Katia Bontempi, Alessandro Cesare Rosa, Paola Colais, Fabio Cruciani, Mariangela D'Ovidio, Francesca Mataloni, Silvia Minozzi, Zuzana Mitrova, Luigi Pinnarelli, Rosella Saulle, Salvatore Soldati, Chiara Sorge, Simona Vecchi, Martina Ventura, Marina Davoli
BACKGROUND Improving quality and effectiveness of healthcare is one of the priorities of health policies. Hospital or physician volume represents a measurable variable with an impact on effectiveness of healthcare. An Italian law calls for the definition of «qualitative, structural, technological, and quantitative standards of hospital care». There is a need for an evaluation of the available scientific evidence in order to identify qualitative, structural, technological, and quantitative standards of hospital care, including the volume of care above or below which the public and private hospitals may be accredited (or not) to provide specific healthcare interventions...
September 2017: Epidemiologia e Prevenzione
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