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https://www.readbyqxmd.com/read/29929047/isolated-hypospadias-the-impact-of-prenatal-exposure-to-pesticides-as-determined-by-meconium-analysis
#1
Elodie Haraux, Pierre Tourneux, Christelle Kouakam, Erwan Stephan-Blanchard, Bernard Boudailliez, Andre Leke, Celine Klein, Karen Chardon
Although endocrine-disrupting chemicals (EDCs, including pesticides) are thought to increase the risk of hypospadias, no compounds have been formally identified in this context. Human studies may now be possible via the assessment of meconium as a marker of chronic prenatal exposure. The objective of the present study was to determine whether or not prenatal exposure to pesticides (as detected in meconium) constitutes a risk factor for isolated hypospadias. In a case-control study performed between 2011 and 2014 in northern France, male newborns with isolated hypospadias (n = 25) were matched at birth with controls (n = 58)...
June 18, 2018: Environment International
https://www.readbyqxmd.com/read/29929039/combination-of-the-fetal-urinary-metabolome-and-peptidome-for-the-prediction-of-postnatal-renal-outcome-in-fetuses-with-puv
#2
Bénédicte Buffin-Meyer, Julie Klein, Benjamin Breuil, Françoise Muller, Panagiotis Moulos, Marion Groussolles, Ourdia Bouali, Jean-Loup Bascands, Stéphane Decramer, Joost P Schanstra
Most of biomarker panels, extracted from single omics traits, still need improvement since they display a gray zone where prediction is uncertain. Here we verified whether a combination of omics traits, fetal urinary metabolites and peptides analyzed in the same sample, improved prediction of postnatal renal function in fetuses with posterior urethral valves (PUV) compared to individual omics traits. Using CE-MS, we explored the urinary metabolome of 13 PUV fetuses with end stage renal disease (ESRD) and 12 PUV fetuses without postnatal ESRD at 2 years postnatally...
June 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29929021/structural-and-biosynthetic-studies-on-eremophilenols-related-to-the-phytoalexin-capsidiol-produced-by-botrytis-cinerea
#3
Ivonne Suárez, Gesiane da Silva Lima, Raphael Conti, Cristina Pinedo, Javier Moraga, Javier Barúa, Ana Ligia L de Oliveira, Josefina Aleu, Rosa Durán-Patrón, Antonio J Macías-Sánchez, James R Hanson, Mônica Tallarico Pupo, Rosario Hernández-Galán, Isidro G Collado
A thorough study of the fermentation broth of three strains of Botrytis cinerea which were grown on a modified Czapek-Dox medium supplemented with 5 ppm copper sulphate, yielded five undescribed metabolites. These metabolites possessed a sesquiterpenoid (+)-4-epi-eremophil-9-ene carbon skeleton which was enantiomeric to that of the phytoalexin, capsidiol. The isolation of these metabolites when the fungus was stressed, suggests that they may be potential effectors used by B. cinerea to circumvent plant chemical defences against phytopathogenic fungi...
June 18, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29929020/integration-of-non-targeted-metabolomics-and-automated-determination-of-elemental-compositions-for-comprehensive-alkaloid-profiling-in-plants
#4
Maryse Vanderplanck, Gaétan Glauser
Plants produce a large array of specialized metabolites to protect themselves. Among these allelochemicals, alkaloids display highly diverse and complex structures that are directly related to their biological activities. Plant alkaloid profiling traditionally requires extensive and time-consuming sample preparation and analysis. Herein, we developed a rapid and efficient approach for the comprehensive profiling of alkaloids in plants using ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS)-based metabolomics...
June 18, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29928786/antitumor-perspectives-of-oleuropein-and-its-metabolite-hydroxytyrosol-recent-updates
#5
REVIEW
Muhammad Imran, Muhammad Nadeem, Syed Amir Gilani, Shaista Khan, Muhammad Wasim Sajid, Rai Muhammad Amir
Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4-dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis...
June 21, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29928571/enhanced-vulnerability-to-oxidative-stress-and-induction-of-inflammatory-gene-expression-in-3-phosphoglycerate-dehydrogenase-deficient-fibroblasts
#6
Momoko Hamano, Yurina Haraguchi, Tomoko Sayano, Chong Zyao, Yashiho Arimoto, Yui Kawano, Kazuki Moriyasu, Miyako Udono, Yoshinori Katakura, Takuya Ogawa, Hisanori Kato, Shigeki Furuya
l-Serine (l-Ser) is a necessary precursor for the synthesis of proteins, lipids, glycine, cysteine, d-serine, and tetrahydrofolate metabolites. Low l-Ser availability activates stress responses and cell death; however, the underlying molecular mechanisms remain unclear. l-Ser is synthesized de novo from 3-phosphoglycerate with 3-phosphoglycerate dehydrogenase (Phgdh) catalyzing the first reaction step. Here, we show that l-Ser depletion raises intracellular H2 O2 levels and enhances vulnerability to oxidative stress in Phgdh-deficient mouse embryonic fibroblasts...
June 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29928490/metabolite-profiling-identifies-a-signature-of-tumorigenicity-in-hepatocellular-carcinoma
#7
Shamir Cassim, Valérie-Ann Raymond, Benoit Lacoste, Pascal Lapierre, Marc Bilodeau
HCC (Hepatocellular carcinoma) cells exhibit greater metabolic plasticity than normal hepatocytes since they must survive in a dynamic microenvironment where nutrients and oxygen are often scarce. Using a metabolomic approach combined with functional in vitro and in vivo assays, we aimed to identify an HCC metabolic signature associated with increased tumorigenicity and patient mortality. Metabolite profiling of HCC Dt81Hepa1-6 cells revealed that their increased tumorigenicity was associated with elevated levels of glycolytic metabolites...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928301/the-mycoparasitic-fungus-clonostachys-rosea-responds-with-both-common-and-specific-gene-expression-during-interspecific-interactions-with-fungal-prey
#8
Kristiina Nygren, Mukesh Dubey, Antonio Zapparata, Mudassir Iqbal, Georgios D Tzelepis, Mikael Brandström Durling, Dan Funck Jensen, Magnus Karlsson
Clonostachys rosea is a necrotrophic mycoparasitic fungus, used for biological control of plant pathogenic fungi. A better understanding of the underlying mechanisms resulting in successful biocontrol is important for knowledge-based improvements of the application and use of biocontrol in agricultural production systems. Transcriptomic analyses revealed that C. rosea responded with both common and specific gene expression during interactions with the fungal prey species Botrytis cinerea and Fusarium graminearum ...
July 2018: Evolutionary Applications
https://www.readbyqxmd.com/read/29928284/seasonal-alterations-in-organic-phosphorus-metabolism-drive-the-phosphorus-economy-of-annual-growth-in-f-sylvatica-trees-on-p-impoverished-soil
#9
Florian Netzer, Cornelia Herschbach, Akira Oikawa, Yozo Okazaki, David Dubbert, Kazuki Saito, Heinz Rennenberg
Phosphorus (P) is one of the most important macronutrients limiting plant growth and development, particularly in forest ecosystems such as temperate beech ( Fagus sylvatica ) forests in Central Europe. Efficient tree internal P cycling during annual growth is an important strategy of beech trees to adapt to low soil-P. Organic P (Porg ) is thought to play a decisive role in P cycling, but the significance of individual compounds and processes has not been elucidated. To identify processes and metabolites involved in P cycling of beech trees, polar-metabolome and lipidome profiling was performed during annual growth with twig tissues from a sufficient (Conventwald, Con) and a low-soil-P (Tuttlingen, Tut) forest...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29928234/the-critical-power-model-as-a-potential-tool-for-anti-doping
#10
REVIEW
Michael J Puchowicz, Eliran Mizelman, Assaf Yogev, Michael S Koehle, Nathan E Townsend, David C Clarke
Existing doping detection strategies rely on direct and indirect biochemical measurement methods focused on detecting banned substances, their metabolites, or biomarkers related to their use. However, the goal of doping is to improve performance, and yet evidence from performance data is not considered by these strategies. The emergence of portable sensors for measuring exercise intensities and of player tracking technologies may enable the widespread collection of performance data. How these data should be used for doping detection is an open question...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29927942/variable-selection-in-omics-data-a-practical-evaluation-of-small-sample-sizes
#11
Alexander Kirpich, Elizabeth A Ainsworth, Jessica M Wedow, Jeremy R B Newman, George Michailidis, Lauren M McIntyre
In omics experiments, variable selection involves a large number of metabolites/ genes and a small number of samples (the n < p problem). The ultimate goal is often the identification of one, or a few features that are different among conditions- a biomarker. Complicating biomarker identification, the p variables often contain a correlation structure due to the biology of the experiment making identifying causal compounds from correlated compounds difficult. Additionally, there may be elements in the experimental design (blocks, batches) that introduce structure in the data...
2018: PloS One
https://www.readbyqxmd.com/read/29927929/acute-stress-response-of-fathead-minnows-caged-downstream-of-municipal-wastewater-treatment-plants-in-the-bow-river-calgary
#12
Analisa Lazaro-Côté, Bastien Sadoul, Leland J Jackson, Mathilakath M Vijayan
We examined whether exposure to municipal wastewater effluent (MWWE) compromised the stress performance of laboratory-reared fathead minnows (Pimephales promelas) in a field setting. Adult minnows were caged at two sites upstream and three sites downstream of wastewater treatments plants (WWTPs) discharging MWWE into the Bow River, Calgary, Alberta, Canada. At each site one group of fish was sampled after a 26 day exposure to MWWE, while another group was subjected to 1-min air exposure followed by 60-min confinement and then sampled...
2018: PloS One
https://www.readbyqxmd.com/read/29927718/multiomics-data-triangulation-for-asthma-candidate-biomarkers-and-precision-medicine
#13
Matija Pecak, Peter Korošec, Tanja Kunej
Asthma is a common complex disorder and has been subject to intensive omics research for disease susceptibility and therapeutic innovation. Candidate biomarkers of asthma and its precision treatment demand that they stand the test of multiomics data triangulation before they can be prioritized for clinical applications. We classified the biomarkers of asthma after a search of the literature and based on whether or not a given biomarker candidate is reported in multiple omics platforms and methodologies, using PubMed and Web of Science, we identified omics studies of asthma conducted on diverse platforms using keywords, such as asthma, genomics, metabolomics, and epigenomics...
June 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29927623/modulating-glucose-metabolism-and-lactate-synthesis-in-injured-mouse-tendons-treatment-with-dichloroacetate-a-lactate-synthesis-inhibitor-improves-tendon-healing
#14
Kairui Zhang, Michael W Hast, Soutarou Izumi, Yu Usami, Snehal Shetye, Ngozi Akabudike, Nancy J Philp, Masahiro Iwamoto, Itzhak Nissim, Louis J Soslowsky, Motomi Enomoto-Iwamoto
BACKGROUND: Tendon injuries are common problems among athletes. Complete recovery of the mechanical structure and function of ruptured tendons is challenging. It has been demonstrated that upregulation of glycolysis and lactate production occurs in wounds, inflammation sites, and cancerous tumors, and these metabolic changes also control growth and differentiation of stem and progenitor cells. Similar metabolic changes have been reported in human healing tendons. In addition, lactate production has increased in progenitors isolated from injured tendons after treatment with IL-1β...
June 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29927576/a-synthetic-light-driven-substrate-channeling-system-for-precise-regulation-of-enzyme-cascade-activity-based-on-dna-origami
#15
Yahong Chen, Guoliang Ke, Yanli Ma, Zhi Zhu, Minghui Liu, Yan Liu, Hao Yan, Chaoyong James Yang
Substrate channeling, in which metabolic intermediate is directly passed from one enzyme to the next enzyme in an enzyme cascade, accelerates the processing of metabolites and improves substrate selectivity. Synthetic design and precise control of channeling outside the cellular environment are of significance in areas such as synthetic biology, synthetic chemistry, and biomedicine. In particular, the precise control of synthetic substrate channeling in response to light is highly important, but remains a major challenge...
June 21, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29927417/-a-role-of-progesterone-and-its-metabolites-in-regulation-functions-of-the-brain
#16
G P Ivanova, L N Gorobets, A V Litvinov, V S Bulanov, L M Vasilenko
The review presents literature data reflecting the nature and mechanism of the effect of progesterone and its metabolites on human and animal brain structures. Particular attention is paid to neuroprotective, anticonvulsant, anti-anxiety and sedative properties of this hormone, which determines the prospect of its use for the prevention and treatment of human neurodegenerative diseases, epilepsy, sleep disorders, and anxiety-depressive spectrum disorders, including premenstrual and climacteric syndromes.
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29927386/phase-i-study-on-safety-and-pharmacokinetics-of-a-novel-influenza-endonuclease-inhibitor-al-794-jnj-64155806-following-single-and-multiple-ascending-doses-in-healthy-adults
#17
Thomas N Kakuda, Jeysen Yogaratnam, Jennifer Rito, Malcolm Boyce, Toni Mitchell, Kusum Gupta, Julian A Symons, Sushmita Chanda, Pieter Van Remoortere, John Fry
BACKGROUND: This double-blind, first-in-human phase 1 study evaluated pharmacokinetics, safety and tolerability of AL-794 (prodrug of ALS-033719), a potent endonuclease inhibitor of influenza A and B in healthy volunteers. METHODS: Healthy adult volunteers were randomized to AL-794 (50-2000 mg single ascending doses, fasting) or placebo (5 cohorts, n=6:2 AL-794: placebo/cohort) in part 1, and AL-794 (50-600 mg multiple ascending doses, twice-daily, fed or fasted) or placebo (3 cohorts, n=8:2 AL-794: placebo/cohort) for 7 days in part 2...
June 21, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/29926968/effect-of-tildrakizumab-mk-3222-a-high-affinity-selective-anti-il23p19-monoclonal-antibody-on-cytochrome-p450-metabolism-in-subjects-with-moderate-to-severe-psoriasis
#18
S Khalilieh, A Hussain, D Montgomery, V Levine, P M Shaw, I Bodrug, L Mekokishvili, C Bailey-Smith, X S Glasgow, A Cheng, M Martinho, M Iwamoto
AIMS: Tildrakizumab, an interleukin (IL)-23 inhibitor, is indicated for the treatment of moderate to severe chronic plaque psoriasis. Although tildrakizumab is not metabolized by, and does not alter, cytochrome P450 (CYP) expression in vitro, clinically-significant pharmacokinetic effects through changes in systemic inflammation, which alters CYP metabolism, have been well documented. At the time of study conduct, the effect of modulation of inflammation/cytokines, including IL-23 inhibition with tildrakizumab, on CYP metabolism, and therefore the potential for disease-drug interactions, in psoriasis patients was unknown...
June 21, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29926818/protective-effects-of-gonadal-hormones-on-spinal-motoneurons-following-spinal-cord-injury
#19
REVIEW
Dale R Sengelaub, Xiao-Ming Xu
Spinal cord injury (SCI) results in lesions that destroy tissue and disrupt spinal tracts, producing deficits in locomotor and autonomic function. The majority of treatment strategies after SCI have concentrated on the damaged spinal cord, for example working to reduce lesion size or spread, or encouraging regrowth of severed descending axonal projections through the lesion, hoping to re-establish synaptic connectivity with caudal targets. In our work, we have focused on a novel target for treatment after SCI, surviving spinal motoneurons and their target musculature, with the hope of developing effective treatments to preserve or restore lost function following SCI...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29926703/analysis-of-growth-and-metabolites-of-pyruvate-dehydrogenase-complex-deficient-klebsiella-pneumoniae-mutant-in-glycerol-based-medium
#20
Danfeng Xu, Zongxiao Jia, Qiyu Chu, Shuilin Fu, Heng Gong
To determine the role of pyruvate dehydrogenase complex (PDHC) in Klebsiella pneumoniae , the growth and metabolism of PDHC-deficient mutant in glycerol-based medium were analyzed and compared with those of other strains. Under aerobic conditions, the PDHC activity was fourfold higher than that of pyruvate formate lyase (PFL), and blocking of PDHC caused severe growth defect and pyruvate accumulation, indicating that the carbon flux through pyruvate to acetyl coenzyme A mainly depended on PDHC. Under anaerobic conditions, although the PDHC activity was only 50 % of that of PFL, blocking of PDHC resulted in more growth defect than blocking of PFL...
May 11, 2018: Journal of Microbiology and Biotechnology
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