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https://www.readbyqxmd.com/read/28346387/oprm1-c-118a-g-polymorphism-and-duration-of-morphine-treatment-associated-with-morphine-doses-and-quality-of-life-in-palliative-cancer-pain-settings
#1
Aline Hajj, Lucine Halepian, Nada El Osta, Georges Chahine, Joseph Kattan, Lydia Rabbaa Khabbaz
Despite increased attention on assessment and management, pain remains the most persistent symptom in patients with cancer, in particular in end-of-life settings, with detrimental impact on their quality-of-life (QOL). We conducted this study to evaluate the added value of determining some genetic and non-genetic factors to optimize cancer pain treatment. Eighty-nine patients were included in the study for the evaluation of palliative cancer pain management. The regression analysis showed that age, OPRM1 single nucleotide polymorphism (SNP), as well as the duration of morphine treatment were significantly associated with morphine doses at 24 h (given by infusion pump; p = 0...
March 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28343777/neisseria-meningitidis-nasopharyngeal-carriage-during-the-hajj-a-cohort-study-evaluating-the-need-for-ciprofloxacin-prophylaxis
#2
Ziad A Memish, Jaffar A Al-Tawfiq, Malak Almasri, Esam I Azhar, Muhammad Yasir, Muneera S Al-Saeed, Huda Ben Helaby, Ray Borrow, Abdulhafeez Turkistani, Abdallah Assiri
BACKGROUND: The annual Muslim pilgrimage has the potential of increase risk for acquisition of Neisseria meningitidis. Here, we evaluate the Hajj impact on the prevalence of N. meningitidis carriage in a paired and non-paired cohort of pilgrims. Secondary objectives were to calculate the compliance with recommended vaccination. METHODS: This is a prospective paired (arriving and departing), non-paired arriving and non-paired departing cohort study with the collection of nasopharyngeal samples at the start and the end of the Hajj...
March 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28332652/the-impact-of-importation-of-live-ruminants-on-the-epizootiology-of-foot-and-mouth-disease-in-saudi-arabia
#3
I H A Abd El-Rahim, A H Asghar, A M Mohamed, S M Fat'hi
Approximately five million live ruminants are imported annually into Saudi Arabia. The majority of these animals are imported shortly before the pilgrimage season from Sudan and the Horn of Africa, where foot and mouth disease (FMD) is known to be enzootic. This study was designed to investigate the impact of the importation of these live ruminants on the epizootiology of FMD in Saudi Arabia. The authors carried out antibody testing on a total of 480 sheep and 233 cattle from the sacrificial livestock yards of the Saudi Project for Utilization of Hajj Meat, which performs ritual slaughter on behalf of pilgrims in the Holy City of Makkah...
December 2016: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28331081/multiple-sources-of-genetic-diversity-of-influenza-a-viruses-during-the-hajj
#4
Joanna C A Cobbin, Mohammad Alfelali, Osamah Barasheed, Janette Taylor, Dominic E Dwyer, Jen Kok, Robert Booy, Edward C Holmes, Harunor Rashid
Outbreaks of respiratory virus infection at mass gatherings pose significant health risks to attendants, host communities and ultimately the global population if they help facilitate viral emergence. However, little is known about the genetic diversity, evolution and patterns of viral transmission during mass gatherings, particularly how much diversity is generated by in situ transmission compared to that imported from other locations. Here we describe the genomic-scale evolution of influenza A viruses sampled from the Hajj at Makkah during 2013-2015...
March 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28323045/vitamin-d-receptor-gene-polymorphisms-among-emirati-patients-with-type-2-diabetes-mellitus
#5
Habiba Al Safar, Sarah El Hajj Chehadeh, Laila Abdel-Wareth, Afrozul Haq, Herbert F Jelinek, Gehad ElGhazali, Fatme Al Anouti
At a prevalence rate close to 19.5%, the UAE has one of the highest rates of Type 2 Diabetes Mellitus (T2DM) in the world. Genome wide association studies (GWAS) have led to the identification of several genetic variants that are associated with T2DM. Recently, genes involved in vitamin D metabolism have gained interest because of the association between vitamin D deficiency (VDD) and increased risk for T2DM. Among these, the Vitamin D receptor (VDR) gene is a good candidate for T2DM susceptibility. The aim of this study was to investigate the association between VDR polymorphisms and T2DM among a representative sample of the Emirati population...
March 16, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28298784/ventilation-of-nonparalyzed-patients-under-anesthesia-with-laryngeal-mask-airway-comparison-of-three-modes-of-ventilation-volume-controlled-ventilation-pressure-controlled-ventilation-and-pressure-controlled-ventilation-volume-guarantee
#6
Maroun Badwi Ghabach, Elie M El Hajj, Rouba D El Dib, Jeanette M Rkaiby, May S Matta, May R Helou
BACKGROUND: Pressure controlled ventilation (PCV) is the preferable mode of ventilation of nonparalyzed patients undergoing anesthesia with laryngeal mask airway (LMA) as compared to volume controlled ventilation (VCV) and spontaneously breathing patient. In this study, we compared the PC-volume guarantee (PC-VG) mode of ventilation with VCV and PCV modes. MATERIALS AND METHODS: A total of 30 patients, American Society of Anesthesiologists (ASA) physical status Classes I and II, scheduled for elective surgery under general anesthesia with a classic LMA were ventilated, subsequently, with the three modes of ventilation: VCV, PCV, and PC-VG for 10 min each mode...
January 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28289047/are-patients-with-cancer-with-sepsis-and-bacteraemia-at-a-higher-risk-of-mortality-a-retrospective-chart-review-of-patients-presenting-to-a-tertiary-care-centre-in-lebanon
#7
Gilbert Abou Dagher, Christopher El Khuri, Ahel Al-Hajj Chehadeh, Ali Chami, Rana Bachir, Dina Zebian, Ralphe Bou Chebl
OBJECTIVE: Most sepsis studies have looked at the general population. The aim of this study is to report on the characteristics, treatment and hospital mortality of patients with cancer diagnosed with sepsis or septic shock. SETTING: A single-centre retrospective study at a tertiary care centre looking at patients with cancer who presented to our tertiary hospital with sepsis, septic shock or bacteraemia between 2010 and 2015. PARTICIPANTS: 176 patients with cancer were compared with 176 cancer-free controls...
March 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28280688/management-of-anastomosis-leakage-post-ralp-a-simple-trick-for-a-complex-situation
#8
Romain Diamand, Walid Al Hajj Obeid, Anna Accarain, Ksenija Limani, Eric Hawaux, Roland van Velthoven, Alexandre Peltier
A case of 74 years old male patient who underwent RALP with bladder neck reconstruction. Persistent vesicourethral anastomotic leak was seen at cystography. A self-made side fenestrated Foley catheter was used and on the day after, a complete reversal in fluid output between the Foley catheter and the drain was seen.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28276596/impact-of-calcium-and-two-doses-of-vitamin-d-on-bone-metabolism-in-the-elderly-a-randomized-controlled-trial
#9
Maya Rahme, Sima-Lynn Sharara, Rafic Baddoura, Robert H Habib, Georges Halaby, Asma Arabi, Ravinder J Singh, Moustapha Kassem, Ziyad Mahfoud, Maha Hoteit, Rose T Daher, Darina Bassil, Karim El Ferkh, Ghada El-Hajj Fuleihan
The optimal dose of vitamin D to optimize bone metabolism in the elderly is unclear. We tested the hypothesis a vitamin D, at a dose higher than recommended by the Institute of Medicine (IOM), has a beneficial effect on bone remodeling and mass. In this double blind trial we randomized 257 overweight elderly subjects to receive 1000 mg of elemental calcium citrate/day, and the daily equivalent of 3,750IU/day or 600 IU/day of vitamin D3 for one year. The subjects' mean age was 71 ± 4 years, body mass index 30 ± 4 kg/m(2) , 55% were women, and 222 completed the 12-months follow-up...
March 9, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28240647/sodium-channels-in-pain-disorders-pathophysiology-and-prospects-for-treatment
#10
Sulayman D Dib-Hajj, Paul Geha, Stephen G Waxman
No abstract text is available yet for this article.
April 2017: Pain
https://www.readbyqxmd.com/read/28235406/network-topology-of-nav1-7-mutations-in-sodium-channel-related-painful-disorders
#11
Dimos Kapetis, Jenny Sassone, Yang Yang, Barbara Galbardi, Markos N Xenakis, Ronald L Westra, Radek Szklarczyk, Patrick Lindsey, Catharina G Faber, Monique Gerrits, Ingemar S J Merkies, Sulayman D Dib-Hajj, Massimo Mantegazza, Stephen G Waxman, Giuseppe Lauria
BACKGROUND: Gain-of-function mutations in SCN9A gene that encodes the voltage-gated sodium channel NaV1.7 have been associated with a wide spectrum of painful syndromes in humans including inherited erythromelalgia, paroxysmal extreme pain disorder and small fibre neuropathy. These mutations change the biophysical properties of NaV1.7 channels leading to hyperexcitability of dorsal root ganglion nociceptors and pain symptoms. There is a need for better understanding of how gain-of-function mutations alter the atomic structure of Nav1...
February 24, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28226273/acute-respiratory-infections-among-returning-hajj-pilgrims-jordan-2014
#12
Mohammad Mousa Al-Abdallat, Brian Rha, Sultan Alqasrawi, Daniel C Payne, Ibrahim Iblan, Alison M Binder, Aktham Haddadin, Mohannad Al Nsour, Tarek Alsanouri, Jawad Mofleh, Brett Whitaker, Stephen L Lindstrom, Suxiang Tong, Sami Sheikh Ali, Rebecca Moritz Dahl, LaShondra Berman, Jing Zhang, Dean D Erdman, Susan I Gerber
BACKGROUND: The emergence of Middle East Respiratory Syndrome coronavirus (MERS-CoV) has prompted enhanced surveillance for respiratory infections among pilgrims returning from the Hajj, one of the largest annual mass gatherings in the world. OBJECTIVES: To describe the epidemiology and etiologies of respiratory illnesses among pilgrims returning to Jordan after the 2014 Hajj. STUDY DESIGN: Surveillance for respiratory illness among pilgrims returning to Jordan after the 2014 Hajj was conducted at sentinel health care facilities using epidemiologic surveys and molecular diagnostic testing of upper respiratory specimens for multiple respiratory pathogens, including MERS-CoV...
April 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28219367/effectiveness-of-a-pharmacist-delivered-smoking-cessation-program-in-the-state-of-qatar-a-randomized-controlled-trial
#13
Maguy Saffouh El Hajj, Nadir Kheir, Ahmad Mohd Al Mulla, Rula Shami, Nadia Fanous, Ziyad R Mahfoud
BACKGROUND: Cigarette smoking is one of the major preventable causes of death and diseases in Qatar. The study objective was to test the effect of a structured smoking cessation program delivered by trained pharmacists on smoking cessation rates in Qatar. METHODS: A prospective randomized controlled trial was conducted in eight ambulatory pharmacies in Qatar. Eligible participants were smokers 18 years and older who smoked one or more cigarettes daily for 7 days, were motivated to quit, able to communicate in Arabic or English, and attend the program sessions...
February 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28216182/-your-health-essential-for-your-hajj-muslim-pilgrims-knowledge-attitudes-and-practices-regarding-middle-east-respiratory-syndrome-coronavirus-mers-cov-during-hajj-season
#14
Faten Alhomoud, Farah Alhomoud
BACKGROUND: Up to date, there have been no studies to evaluate pilgrims' knowledge, attitude and practices regarding MERS-CoV during the annual Hajj pilgrimage in order to see whether there is a need for these aspects to be improved. METHODS: A cross-sectional survey study was conducted with a convenience sampling. Participants were pilgrims, aged over 18, and able to speak Arabic or English. A self-administered structured questionnaire was distributed during Hajj season in Mecca...
February 16, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28201840/clinical-response-to-dorsal-duct-drainage-via-the-minor-papilla-in-refractory-obstructing-chronic-calcific-pancreatitis
#15
Chang-Il Kwon, Mark A Gromski, Stuart Sherman, Ihab I El Hajj, Jeffrey J Easler, James Watkins, Lee McHenry, Glen A Lehman, Evan L Fogel
Background and study aims Complete stone removal from the main pancreatic duct might not be achieved in all patients with obstructive chronic calcific pancreatitis. We report our results for endoscopic dorsal pancreatic duct (DPD) bypass of obstructing stones in the ventral pancreatic duct (VPD). Patients and methods 16 patients with obstructive chronic calcific pancreatitis were treated with a DPD bypass. Clinical success was defined as significant pain relief and no hospital admissions for pain management during the ongoing treatment period...
April 2017: Endoscopy
https://www.readbyqxmd.com/read/28198548/phylogenetic-characterization-of-circulating-dengue-and-alkhumra-hemorrhagic-fever-viruses-in-western-saudi-arabia-and-lack-of-evidence-of-zika-virus-in-the-region-a-retrospective-study-2010-2015
#16
Moneerah S Al-Saeed, Sherif A El-Kafrawy, Suha A Farraj, Tagreed L Al-Subhi, Norah A Othman, Arwa Alsultan, Huda G Ben Helaby, Mustafa M Alshawdari, Ahmed M Hassan, Remi N Charrel, Esam I Azhar, Anwar M Hashem
Flaviviruses represent a global public health concern. They consist of ∼70 viruses with almost half of them causing human diseases with unspecified febrile illnesses. Cities in western Saudi Arabia are endemic for viruses (DENV) with sporadic infections due to Alkhumra hemorrhagic fever virus (AHFV). They also represent a major destination for travelers coming for annual religious pilgrimages (Hajj and Umrah) from all over the world. However, whether other flaviviruses are circulating is not known because of the limited number of surveillance studies...
February 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28191331/development-of-dual-taqman-based-one-step-rrt-pcr-assay-panel-for-rapid-and-accurate-diagnostic-test-of-mers-cov-a-novel-human-coronavirus-ahead-of-hajj-pilgrimage
#17
Mohammad Sadegh Hashemzadeh, Rahimeh Rasouli, Bentolhoda Zahraei, Morteza Izadi, Mahdi Tat, Seyed Hassan Saadat, Mohammad Najarasl, Behzad Khansari Nejad, Ruhollah Dorostkar
BACKGROUND: Coronaviruses (CoVs) are large ribonucleic acid (RNA) viruses causing primarily respiratory disease in humans. A novel human coronavirus, subsequently named middle east respiratory syndrome coronavirus (MERS-CoV), was first reported in Saudi Arabia in September of 2012. With increasing numbers of infections and deaths from MERS-CoV, development of a rapid and reliable kit was crucial to prevent further spread of MERS-CoV. OBJECTIVES: In this study, we present two real-time reverse-transcription polymerase chain reaction (rRT-PCR) assays for in-house rapid and sensitive diagnostic testing of MERS-CoV, detecting the regions upstream of the envelope gene (upE) and open reading frame (ORF) 1b, respectively, for initial screening and final confirmation of MERS-CoV infection, as recommended by the world health organization (WHO)...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28186371/gene-expression-and-epigenetic-aberrations-in-f1-placentas-fathered-by-obese-males
#18
Megan Mitchell, Reiner Strick, Pamela L Strissel, Ralf Dittrich, Nicole O McPherson, Michelle Lane, Galyna Pliushch, Ramya Potabattula, Thomas Haaf, Nady El Hajj
Gene expression and/or epigenetic deregulation may have consequences for sperm and blastocysts, as well as for the placenta, together potentially contributing to problems observed in offspring. We previously demonstrated specific perturbations of fertilization, blastocyst formation, implantation, as well as aberrant glucose metabolism and adiposity in offspring using a mouse model of paternal obesity. The current investigation analysed gene expression and methylation of specific CpG residues in F1 placentas of pregnancies fathered by obese and normal-weight male mice, using real-time PCR and bisulfite pyrosequencing...
February 10, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28184365/mass-fatalities-in-hajj-in-2015
#19
EDITORIAL
Mohammad Ganjeh, Behzad Einollahi
No abstract text is available yet for this article.
November 2016: Trauma Monthly
https://www.readbyqxmd.com/read/28179986/-pseudomonas-saudimassiliensis-sp-nov-a-new-bacterial-species-isolated-from-air-samples-in-the-urban-environment-of-makkah-saudi-arabia
#20
E I Azhar, A Papadioti, F Bibi, A M Ashshi, D Raoult, E Angelakis
We report here the main characteristics of 'Pseudomonas saudimassiliensis' strain 12M76_air(T) (CSUR P1220), a new species of the Pseudomonas genus that was isolated from air samples in the city environment of Makkah, Saudi Arabia, during the pilgrim period of Hajj 2012.
March 2017: New Microbes and New Infections
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