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Milad C El Hajj, Van K Ninh, Elia C El Hajj, Jessica M Bradley, Jason D Gardner
We have previously demonstrated the cardioprotective effects of ovarian hormones against adverse ventricular remodeling imposed by chronic volume overload. Here, we assess the estrogen receptor dependence of this cardioprotection. Four groups of female rats were studied: sham-operated (SHAM), volume overloaded (ACF), SHAM treated with estrogen receptor antagonist, ICI 182,780 (SHAM+ICI), and ACF treated with ICI. Cardiac function was assessed temporally using echocardiogram and tissue samples were collected at 5 days and 6 weeks post-surgery...
October 21, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Robert A Adler, Ghada El-Hajj Fuleihan, Douglas C Bauer, Pauline M Camacho, Bart L Clarke, Gregory A Clines, Juliet E Compston, Matthew T Drake, Beatrice J Edwards, Murray J Favus, Susan L Greenspan, Ross McKinney, Robert J Pignolo, Deborah E Sellmeyer
No abstract text is available yet for this article.
October 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Qanta A Ahmed, Ziad A Memish
Hajj is among the world's largest mass gatherings, drawing between 2 and 3.5 million Muslims from 183 nations annually to perform pilgrimage in Mecca, Saudi Arabia. Infectious disease outbreaks can be imported both into the Hajj population and exported internationally by returning pilgrims. The domestic Saudi population can also be at risk of outbreaks traveling amid this mass migration. With yellow fever reported for the first time in China following the infection of expatriate Chinese workers in Angola and a full blown outbreak underway in wider West Africa, the prospect of yellow fever outbreaks in Asia threatens to impact Saudi Arabia, both during and beyond the Hajj season...
October 17, 2016: Frontiers of Medicine
Catherine Forconi, Philippe Gatault, Elodie Miquelestorena-Standley, Johan Noble, Sally Al-Hajj, Romain Guillemain, Marc Stern, Thomas Hoffmann, Louis Prat, Caroline Suberbielle, Emeline Masson, Anne Cesbron-Gautier, Catherine Gaudy-Graffin, Alain Goudeau, Gilles Thibault, Fabrice Ivanes, Roseline Guibon, Ihab Kazma, Yvon Lebranchu, Matthias Büchler, Antoine Magnan, Jean-Michel Halimi, Christophe Baron
BACKGROUND: Cytomegalovirus (CMV) has a role in chronic rejection and graft loss in kidney transplant (KTx) and lung transplant (LTx) recipients. In addition, donor CMV seropositivity is an independent risk factor for renal graft loss. The anti-CMV response might modulate this risk. Expression of programmed cell death 1 (PD-1), a receptor involved in viral-specific T-cell exhaustion, is influenced by a single nucleotide polymorphism called PD-1.3 (wild-type allele G, variant allele A)...
August 26, 2016: Journal of Heart and Lung Transplantation
Qanta A Ahmed, Rana F Kattan, Ziad A Memish
No abstract text is available yet for this article.
October 14, 2016: American Journal of Infection Control
Shu Y Ng, Kathryn L Colborn, Lajhem Cambridge, Carla Hajj, T Jonathan Yang, Abraham J Wu, Karyn A Goodman
BACKGROUND AND PURPOSE: We examined acute toxicity profiles and outcomes among rectal cancer patients treated with pre-operative chemoradiation using intensity modulated radiotherapy (IMRT) or 3-dimensional conformal radiotherapy (3DCRT) to identify predictive clinical factors associated with increased acute toxicity. MATERIAL AND METHODS: We retrospectively reviewed records of 301 consecutive rectal cancer patients treated with pre-operative chemotherapy and radiotherapy (median dose 5000cGy) at our institution between 2007 and 2014...
October 14, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Stephanie C El Hajj, Michael R Gold
No abstract text is available yet for this article.
October 2016: Circulation. Cardiovascular Imaging
Alla El-Awaisi, Maguy Saffouh El Hajj, Sundari Joseph, Lesley Diack
The current status of interprofessional education (IPE) in Arabic Middle Eastern countries is largely unexamined and there is a need to assess IPE and collaborative practice in these countries. As faculty attitudes towards IPE are believed to be one of the main factors that affect the successful integration of IPE into the different healthcare curricula, this article aims to explore the attitudes and views of pharmacy academics in Arabic-speaking Middle Eastern countries towards IPE and collaborative practice...
October 5, 2016: Journal of Interprofessional Care
Payman Salamati, Vafa Rahimi-Movaghar
No abstract text is available yet for this article.
June 2016: Archives of Trauma Research
Maude Dulac, Guy El Hajj Boutros, Charlotte Pion, Sébastien Barbat-Artigas, Gilles Gouspillou, Mylène Aubertin-Leheudre
Objective: To investigate whether handgrip strength normalized to body weight could be a useful clinical tool to identify dynapenia and assess functional capacity in post-menopausal women. Method: A total of 136 postmenopausal women were recruited. Body composition (Dual Energy X-ray Absorptiometry [DEXA], Bio-electrical Impedence Analysis [BIA]), grip strength (dynamometer) and functional capacity (senior fitness tests) were evaluated. Dynapenia was established according to a handgrip strength index (handgrip strength divided by body weight (BW) in Kg/KgBW) obtained from a reference population of young women: Type I dynapenic (<0...
September 15, 2016: Brazilian Journal of Physical Therapy
Maria Matar, Laila Al-Shaar, Joyce Maalouf, Mona Nabulsi, Asma Arabi, Mahmoud Choucair, Hani Tamim, Ghada El-Hajj Fuleihan
BACKGROUND: Little is known about the changes in calciotropic hormones during puberty and their relationship to bone mass during this critical period for skeletal accretion. OBJECTIVES: Investigate changes in calciotropic hormones, IGF1, body composition and their associations with bone metabolism in adolescents. METHODS: Post-hoc analyses from data on 335 healthy school children, ages 10-17 years, with hypovitaminosis D, who participated in a vitamin D randomized controlled trial...
September 27, 2016: Journal of Clinical Endocrinology and Metabolism
Aline Hajj, Rima Chedid, Eliane Chouery, André Megarbané, Marie-Hélène Gannagé-Yared
AIM: To explore the association between VDR polymorphisms and several cardiovascular risk factors and adiponectin. MATERIALS & METHODS: Three-hundred and sixty-nine healthy students were randomly selected. Five VDR polymorphisms were genotyped: BsmI rs1544410; Cdx2 rs11568820; ApaI rs7975232; TaqI rs731236 and FokI rs2228570. BMI, waist circumference (WC), blood pressure, lipid/glycemic profiles and adiponectin were assessed. RESULTS: In men, BsmI, ApaI and TaqI were associated with BMI and WC (p < 0...
October 2016: Pharmacogenomics
Marcos Vinicios Salles Dias, Vilma Regina Martins, Glaucia Noeli Maroso Hajj
This chapter is derived from our experience in the study of stress-Inducible Protein 1 (STI1) in extracellular vesicles. We used different techniques to isolate, explore, and characterize the extracellular vesicles that contained this protein. Ultracentrifugation and gel chromatography were used to isolate extracellular vesicles of different sizes, nanotracking particle analysis (NTA) determined number and size of vesicles, while flow cytometry and ELISA were used to determine the specific protein content of vesicles...
2016: Methods in Molecular Biology
Stefanie Atsem, Juliane Reichenbach, Ramya Potabattula, Marcus Dittrich, Caroline Nava, Christel Depienne, Lena Böhm, Simone Rost, Thomas Hahn, Martin Schorsch, Thomas Haaf, Nady El Hajj
Children of older fathers carry an increased risk for developing autism and other disorders. To elucidate the underlying mechanisms, we investigated the correlation of sperm DNA methylation with paternal age and its impact on the epigenome of the offspring. Methylation levels of 9 candidate genes and LINE-1 repeats were quantified by bisulfite pyrosequencing in sperm of 162 donors and 191 cord blood of resulting children (conceived by IVF/ICSI with the same sperm samples). Four genes showed a significant negative correlation between sperm methylation and paternal age...
September 23, 2016: Human Molecular Genetics
Qanta A Ahmed, Ziad A Memish
No abstract text is available yet for this article.
September 20, 2016: Travel Medicine and Infectious Disease
Rim Mzid, Farhat Chibani, Rayda Ben Ayed, Mohsen Hanana, Joelle Breidi, Rabih Kabalan, Samih El-Hajj, Hassan Machlab, Ahmed Rebai, Lamis Chalak
No abstract text is available yet for this article.
September 2016: Journal of Genetics
M Chakhtoura, W D Leslie, M McClung, A M Cheung, G El-Hajj Fuleihan
: We describe our approach to develop FRAX-based osteoporosis treatment guidelines in Lebanon, a country with low-moderate fracture rates. A hybrid assessment algorithm that combines a fixed 10 % intervention threshold until age 70 years, and an age-dependent threshold thereafter, was deemed most suitable. INTRODUCTION: The FRAX risk calculator is used to guide intervention thresholds in several national osteoporosis guidelines. This study aimed to describe the approach in developing FRAX-based osteoporosis treatment guidelines in Lebanon, a country with relatively low fracture rates...
September 20, 2016: Osteoporosis International
Anas A Khan, Eric K Noji
The Hajj is an annual religious mass gathering that takes place in Makkah, Saudi Arabia. The complexity of its system is multidimensional, with religious, political, cultural, security, economic, communication, operational, and logistic unique challenges. This year, yet another stampede tragedy that caused around a 1,000 deaths and severe injuries, capturing worldwide media attention and exacerbating existing political tensions across the Gulf coasts was faced. Planning is important but the planning process is more important, requiring systematic analysis based on accurate collected and targeting root cause factors...
2016: American Journal of Disaster Medicine
Nahla Khamis Ibrahim
OBJECTIVE: To describe Zika Virus (ZIKV) epidemiology, current phobia, and the required preparedness for its prevention during the upcoming Mass Gathering (MG) events. METHODS: Electronic databases of PubMed, WHO, CDC, Pan American Health Organization (PAHO), Google, and Cochrane library were extensively searched for ZIKV. Articles were reviewed, scrutinized and critically appraised and the most relevant articles were utilized. RESULTS: ZIKV is an emerging Flavivirus which was first isolated from Uganda in 1947...
July 2016: Pakistan Journal of Medical Sciences Quarterly
Mazen El Sayed, Hani Tamim, Ahel Al-Hajj Chehadeh, Amin A Kazzi
BACKGROUND: Early activation and use of Emergency Medical Services (EMS) are associated with improved patient outcomes in EMS priority conditions in developed EMS systems. This study describes patterns of EMS use and identifies predictors of EMS utilization in EMS priority conditions in Lebanon METHODS: This was a cross-sectional study of a random sample of adult patients presenting to the emergency department (ED) of a tertiary care center in Beirut with the following EMS priority conditions: chest pain, major trauma, respiratory distress, cardiac arrest, respiratory arrest, and airway obstruction...
September 19, 2016: Prehospital and Disaster Medicine
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