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https://www.readbyqxmd.com/read/28625816/a-prospective-multicenter-study-evaluating-learning-curves-and-competence-in-endoscopic-ultrasound-and-endoscopic-retrograde-cholangiopancreatography-among-advanced-endoscopy-trainees-the-rapid-assessment-of-trainee-endoscopy-skills-rates-study
#1
Sachin Wani, Rajesh Keswani, Matt Hall, Samuel Han, Meer Akbar Ali, Brian Brauer, Linda Carlin, Amitabh Chak, Dan Collins, Gregory A Cote, David L Diehl, Christopher J DiMaio, Andrew Dries, Ihab El-Hajj, Swan Ellert, Kimberley Fairley, Ashley Faulx, Larissa Fujii-Lau, Srinivas Gaddam, Seng-Ian Gan, Jonathan P Gaspar, Chitiki Gautamy, Stuart Gordon, Cynthia Harris, Sarah Hyder, Ross Jones, Stephen Kim, Srinadh Komanduri, Ryan Law, Linda Lee, Rawad Mounzer, Daniel Mullady, V Raman Muthusamy, Mojtaba Olyaee, Patrick Pfau, Shreyas Saligram, Cyrus Piraka, Amit Rastogi, Laura Rosenkranz, Fadi Rzouq, Aditi Saxena, Raj J Shah, Violette C Simon, Aaron Small, Jayaprakash Sreenarasimhaiah, Andrew Walker, Andrew Y Wang, Rabindra R Watson, Robert H Wilson, Patrick Yachimski, Dennis Yang, Steven Edmundowicz, Dayna S Early
BACKGROUND AND AIMS: Based on the Next Accreditation System, trainee assessment should occur on a continuous basis with individualized feedback. We aimed to validate endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) learning curves among advanced endoscopy trainees (AETs) using a large national sample of training programs and to develop a centralized database that allows assessment of performance in relation to peers. METHODS: ASGE recognized training programs were invited to participate and AETs were graded on ERCP and EUS exams using a validated competency assessment tool that assesses technical and cognitive competence in a continuous fashion...
June 15, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28619754/antitumor-effect-of-the-atypical-retinoid-st1926-in-acute-myeloid-leukemia-and-nanoparticle-formulation-prolongs-lifespan-and-reduces-tumor-burden-of-xenograft-mice
#2
Leeanna El-Houjeiri, Walid Saad, Berthe Hayar, Patrick Aouad, Nadim Tawil, Rana Abdel-Samad, Rita Hleihel, Maguy Hamie, Angelo Mancinelli, Claudio Pisano, Hiba El Hajj, Nadine Darwiche
Acute myeloid leukemia (AML) is one of the most frequent types of blood malignancies. It is a complex disorder of undifferentiated hematopoietic progenitor cells. The majority of patients generally respond to intensive therapy. Nevertheless, relapse is the major cause of death in AML, warranting the need for novel treatment strategies. Retinoids have demonstrated potent differentiation and growth regulatory effects in normal, transformed and hematopoietic progenitor cells. All-trans retinoic acid (ATRA) is the paradigm of treatment in acute promyelocytic leukemia, an AML subtype...
June 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28619416/mass-gatherings-and-public-health-case-studies-from-the-hajj-to-mecca
#3
Juma Rahman, Min Thu, Neelam Arshad, Marc Van der Putten
BACKGROUND: Many new and challenging risks can be introduced during mass gatherings. The Hajj, as one of the largest mass gatherings, provides an excellent annual opportunity to reflect on the public health risk posed by international and multicultural crowds and the value of mitigation strategies. OBJECTIVES: To identify the gap between preparation and training taken before being exposed to the mass gathering and postexposure experiences, and the breach between the expectations and reality of the holy place...
March 2017: Annals of Global Health
https://www.readbyqxmd.com/read/28609400/cytomegalovirus-viraemia-is-associated-with-poor-growth-and-t-cell-activation-with-an-increased-burden-in-hiv-exposed-uninfected-infants
#4
Miguel A Garcia-Knight, Eunice Nduati, Amin S Hassan, Irene Nkumama, Timothy J Etyang, Naseem J Hajj, Faith Gambo, Denis Odera, James A Berkley, Sarah L Rowland-Jones, Britta Urban
OBJECTIVE: Factors associated with poor health in HIV-exposed-uninfected (HEU) infants are poorly defined. We describe the prevalence and correlates of CMV viraemia in HEU and HIV-unexposed-uninfected (HUU) infants, and quantify associations with anthropometric, haematological and immunological outcomes. DESIGN: Cross-sectional, including HEU and HUU infants from rural coastal Kenya. METHODS: Infants aged 2-8 months were studied. The primary outcome was CMV viraemia and viral load, determined by quantitative PCR...
June 12, 2017: AIDS
https://www.readbyqxmd.com/read/28606757/myeloid-sarcoma-of-the-sigmoid-colon-an-unusual-presentation-of-a-rare-condition
#5
Ihab I El Hajj, Jeffrey J Easler, Eugene P Ceppa, Safi Shahda
No abstract text is available yet for this article.
May 24, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28594907/gastrointestinal-cancer-cells-treatment-with-bevacizumab-activates-a-vegf-autoregulatory-mechanism-involving-telomerase-catalytic-subunit-htert-via-pi3k-akt-hif-1%C3%AE-and-vegf-receptors
#6
Nadine Mahfouz, Roula Tahtouh, Nada Alaaeddine, Joelle El Hajj, Riad Sarkis, Ray Hachem, Issam Raad, George Hilal
BACKGROUND: Targeting angiogenesis has been considered a promising treatment of choice for a large number of malignancies, including gastrointestinal cancers. Bevacizumab is an anti-vascular endothelial growth factor (anti-VEGF) being used for this purpose. However, treatment efficacy is largely questioned. Telomerase activity, responsible for cancer cell immortality, is detected in 85-95% of human cancers and is considered a potential regulator of VEGF. The aim of our study was to investigate the interrelationship between VEGF and hTERT in gastrointestinal cancers and to explore cell response to a combined inhibition of telomerase and VEGF...
2017: PloS One
https://www.readbyqxmd.com/read/28579474/cytology-brushing-of-a-pancreas-cyst-wall-for-the-diagnosis-of-cystic-neuroendocrine-tumor-when-fna-fails
#7
Ihab I El Hajj, Robert E Emerson, Mohammad Al-Haddad
No abstract text is available yet for this article.
May 18, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28575352/dna-methylation-signatures-in-cord-blood-of-icsi-children
#8
Nady El Hajj, Larissa Haertle, Marcus Dittrich, Sarah Denk, Harald Lehnen, Thomas Hahn, Martin Schorsch, Thomas Haaf
STUDY QUESTION: Does ICSI induce specific DNA methylation changes in the resulting offspring? SUMMARY ANSWER: Although several thousand analyzed CpG sites (throughout the genome) displayed significant between-group methylation differences, both ICSI and spontaneously conceived children varied within the normal range of methylation variation. WHAT IS KNOWN ALREADY: Children conceived by ART have increased risks for medical problems at birth and to the extent of present knowledge also in later life (i...
May 31, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28559279/the-ubik-protein-is-an-accessory-factor-necessary-for-bacterial-ubiquinone-uq-biosynthesis-and-forms-a-complex-with-the-uq-biogenesis-factor-ubij
#9
Laurent Loiseau, Cameron Fyfe, Laurent Aussel, Mahmoud Hajj Chehade, Sara B Hernández, Bruno Faivre, Djemel Hamdane, Caroline Mellot-Draznieks, Bérengère Rascalou, Ludovic Pelosi, Christophe Velours, David Cornu, Murielle Lombard, Josep Casadesús, Fabien Pierrel, Marc Fontecave, Frédéric Barras
Ubiquinone (UQ), also referred to as coenzyme Q, is a widespread lipophilic molecule in both prokaryotes and eukaryotes in which it primarily acts as an electron carrier. Eleven proteins are known to participate in UQ biosynthesis in Escherichia coli, and we recently demonstrated that UQ biosynthesis requires additional, nonenzymatic factors, some of which are still unknown. Here, we report on the identification of a bacterial gene, yqiC, which is required for efficient UQ biosynthesis, and which we have renamed ubiK...
May 30, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28549141/risk-factors-for-acquisition-of-ctx-m-genes-in-pilgrims-during-hajj-2013-and-2014
#10
Thongpan Leangapichart, Hervé Tissot-Dupont, Didier Raoult, Ziad A Memish, Jean-Marc Rolain, Philippe Gautret
Background: Mass gatherings, especially the Hajj pilgrimage, provide favourable conditions for bacterial transmission among participants, which might contribute to the international spread of ESBL-producing Enterobacteriaceae (ESBL-E). Objectives: We conducted an analysis aimed at investigating risk factors for CTX-M gene ( bla CTX-M ) rectal carriage in 2013 and 2014 Hajj pilgrims. Methods: A total of 218 pilgrims provided paired pre- and post-Hajj rectal samples (2013, 129 pilgrims; 2014, 89 pilgrims)...
May 26, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28548111/corrigendum-pharmacological-characterisation-of-the-highly-nav1-7-selective-spider-venom-peptide-pn3a
#11
Jennifer R Deuis, Zoltan Dekan, Joshua S Wingerd, Jennifer J Smith, Nehan R Munasinghe, Rebecca F Bhola, Wendy L Imlach, Volker Herzig, David A Armstrong, K Johan Rosengren, Frank Bosmans, Stephen G Waxman, Sulayman D Dib-Hajj, Pierre Escoubas, Michael S Minett, Macdonald J Christie, Glenn F King, Paul F Alewood, Richard J Lewis, John N Wood, Irina Vetter
No abstract text is available yet for this article.
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28542529/associations-between-quality-of-life-physical-activity-worry-depression-and-insomnia-a-cross-sectional-designed-study-in-healthy-pregnant-women
#12
Danielle Mourady, Sami Richa, Rita Karam, Tatiana Papazian, Fabienne Hajj Moussa, Nada El Osta, Assaad Kesrouani, Joseph Azouri, Hicham Jabbour, Aline Hajj, Lydia Rabbaa Khabbaz
Health-related quality of life (QOL) is reported to be reduced during pregnancy. Associations between QOL, physical activity (PA), insomnia, depression and worry are insufficiently investigated among pregnant women. The aim of this study was to evaluate QOL and PA patterns among healthy pregnant women, and to examine how QOL might correlate to PA, sleep, worry and depression. This is an observational cross-sectional study, conducted among a convenient sample of 141 healthy pregnant women using five questionnaires: WHOQOL-brief (WHO quality of life questionnaire, brief version, ISI (Insomnia Severity Index), PSWQ (Penn State Worry Questionnaire), ZSRDS (Zung Self-Rating Depression Scale), and Pregnancy Physical Activity Questionnaire (PPAQ)...
2017: PloS One
https://www.readbyqxmd.com/read/28530638/sodium-channel-nav1-9-mutations-associated-with-insensitivity-to-pain-dampen-neuronal-excitability
#13
Jianying Huang, Carlos G Vanoye, Alison Cutts, Y Paul Goldberg, Sulayman D Dib-Hajj, Charles J Cohen, Stephen G Waxman, Alfred L George
Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on NaV1.7 and NaV1.8 established clear relationships between perturbations in channel function and divergent clinical phenotypes. By contrast, studies of NaV1.9 mutations have not revealed a clear relationship of channel dysfunction with the associated and contrasting clinical phenotypes. Here, we have elucidated the functional consequences of a NaV1...
May 22, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28508371/efficient-and-accurate-algorithm-for-cleaved-fragments-prediction-cfpa-in-protein-sequences-dataset-based-on-consensus-and-its-variants-a-novel-degradomics-prediction-application
#14
Atlal El-Assaad, Zaher Dawy, Georges Nemer, Hazem Hajj, Firas H Kobeissy
Degradomics is a novel discipline that involves determination of the proteases/substrate fragmentation profile, called the substrate degradome, and has been recently applied in different disciplines. A major application of degradomics is its utility in the field of biomarkers where the breakdown products (BDPs) of different protease have been investigated. Among the major proteases assessed, calpain and caspase proteases have been associated with the execution phases of the pro-apoptotic and pro-necrotic cell death, generating caspase/calpain-specific cleaved fragments...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28468249/unconventional-secretion-of-heat-shock-proteins-in-cancer
#15
REVIEW
Tiago Góss Santos, Vilma Regina Martins, Glaucia Noeli Maroso Hajj
Heat shock proteins (HSPs) are abundant cellular proteins involved with protein homeostasis. They have both constitutive and inducible isoforms, whose expression levels are further increased by stress conditions, such as temperature elevation, reduced oxygen levels, infection, inflammation and exposure to toxic substances. In these situations, HSPs exert a pivotal role in offering protection, preventing cell death and promoting cell recovery. Although the majority of HSPs functions are exerted in the cytoplasm and organelles, several lines of evidence reveal that HSPs are able to induce cell responses in the extracellular milieu...
April 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28460030/subcutaneous-cardioverter-defibrillator-has-longer-time-to-therapy-but-is-less-cardiotoxic-than-transvenous-cardioverter-defibrillator-study-carried-out-in-a-preclinical-porcine-model
#16
Rodrigue Garcia, Sofiane Inal, Frederic Favreau, Christophe Jayle, Thierry Hauet, Patrick Bruneval, Thomas Kerforne, Jamil Hajj-Chahine, Bruno Degand
Aims: Totally subcutaneous implantable cardioverter defibrillator (S-ICD) delivers higher shock energy and can have longer time to therapy compared to transvenous implantable cardioverter defibrillator (T-ICD). Aim of the study was to compare time to therapy and to investigate cardiac, cerebral and systemic injuries of S-ICD and T-ICD shocks delivered after ventricular fibrillation (VF) induction. Methods and results: Fourteen pigs were randomly implanted with a S-ICD (n = 7) or a T-ICD (n = 7)...
April 27, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28455205/meningococcal-disease-in-the-middle-east-and-africa-findings-and-updates-from-the-global-meningococcal-initiative
#17
REVIEW
Ray Borrow, Dominique A Caugant, Mehmet Ceyhan, Hannah Christensen, Ener Cagri Dinleyici, Jamie Findlow, Linda Glennie, Anne Von Gottberg, Amel Kechrid, Julio Vázquez Moreno, Aziza Razki, Vincent Smith, Muhamed-Kheir Taha, Hassiba Tali-Maamar, Khalid Zerouali
The Global Meningococcal Initiative (GMI) has recently considered current issues in Middle Eastern and African countries, and produced two recommendations: (i) that vaccination of attendees should be considered for some types of mass-gathering events, as some countries mandate for the Hajj, and (ii) vaccination of people with human immunodeficiency virus should be used routinely, because of increased meningococcal disease (MD) risk. Differences exist between Middle Eastern and African countries regarding case and syndrome definitions, surveillance, and epidemiologic data gaps...
April 25, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28455183/the-effects-of-competition-and-implicit-power-motive-on-men-s-testosterone-emotion-recognition-and-aggression
#18
John G Vongas, Raghid Al Hajj
A contribution to a special issue on Hormones and Human Competition. We investigated the effects of competition on men's testosterone levels and assessed whether androgen reactivity was associated with subsequent emotion recognition and reactive and proactive aggression. We also explored whether personalized power (p Power) moderated these relationships. In Study 1, 84 males competed on a number tracing task and interpreted emotions from facial expressions. In Study 2, 72 males competed on the same task and were assessed on proactive and reactive aggression...
May 2, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28403940/vitamin-d-replacement-in-children-adolescents-and-pregnant-women-in-the-middle-east-and-north-africa-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
REVIEW
Marlene Chakhtoura, Sara El Ghandour, Khaled Shawwa, Elie A Akl, Asma Arabi, Ziyad Mahfoud, Robert Habib, Hassan Hoballah, Ghada El Hajj Fuleihan
INTRODUCTION: Hypovitaminosis D affects one-third to two-thirds of children and pregnant women from the Middle East and North Africa (MENA) region. OBJECTIVE: To evaluate in infants, children, adolescents and pregnant women, from the MENA region, the effect of supplementation with different vitamin D doses on the change in 25-hydroxyvitamin D [25(OH)D] level reached, and other skeletal and non-skeletal outcomes. METHODS: This is a systematic review of randomized controlled trials of vitamin D supplementation conducted in the MENA region...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28400457/emergency-nurse-disaster-preparedness-during-mass-gatherings-a-cross-sectional-survey-of-emergency-nurses-perceptions-in-hospitals-in-mecca-saudi-arabia
#20
Fuad Alzahrani, Kyratsis Yiannis
OBJECTIVES: To assess hospital emergency nurses' self-reported knowledge, role awareness and skills in disaster response with respect to the Hajj mass gathering in Mecca. DESIGN: Cross-sectional online survey with primary data collection and non-probabilistic purposive sample conducted in late 2014. SETTING: All 4 public hospitals in Mecca, Saudi Arabia. PARTICIPANTS: 106 registered nurses in hospital emergency departments...
April 11, 2017: BMJ Open
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