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Rana El Hajj, Hiba El Hajj, Ibrahim Khalifeh
Visceral leishmaniasis, a fatal disease if not treated, is caused by Leishmania parasites. This disease might be overlooked in the Middle East because of limited awareness and low incidence. We report 5 patients who died of visceral leishmaniasis in Lebanon and make recommendations to improve faster diagnosis and treatment.
May 2018: Emerging Infectious Diseases
Doaa A Abdelmoety, Nahid K El-Bakri, Wedian O Almowalld, Zyad A Turkistani, Bassam H Bugis, Eshraq A Baseif, Mohamed H Melbari, Khaled AlHarbi, Amani Abu-Shaheen
Introduction: Data regarding the characteristics and outcomes of heat illness are lacking in the literature. The present study aimed to identify the clinical characteristics, morbidity, management, and mortality associated with heat illness among Hajj participants. Methods: A cross-sectional study was conducted during the Hajj in 2016 on patients who presented to emergency departments and were diagnosed with heat exhaustion or heatstroke. Data were collected using a structured collection sheet developed based on the literature...
2018: BioMed Research International
Sara Moodad, Abdou Akkouche, Rita Hleihel, Nadine Darwiche, Marwan El-Sabban, Ali Bazarbachi, Hiba El Hajj
Adult T cell Leukemia (ATL) is an aggressive lymphoproliferative malignancy secondary to infection by the human T-cell leukemia virus type I (HTLV-I) and is associated with a dismal prognosis. ATL leukemogenesis remains enigmatic. In the era of precision medicine in oncology, mouse models offer one of the most efficient in vivo tools for the understanding of the disease biology and developing novel targeted therapies. This review provides an up-to-date and comprehensive account of mouse models developed in the context of ATL and HTLV-I infection...
2018: Frontiers in Microbiology
Feroze Ganaie, Geetha Nagraj, Vandana Govindan, Reyaz Basha, Mohib Hussain, Nazar Ashraf, Shafique Ahmed, K L Ravikumar
BACKGROUND: The population flow dynamics of Hajj increases the probability of pneumococcal acquisition and amplification among Hajis. This multi-site longitudinal molecular surveillance study was designed to assess the impact and potential variations of pneumococcal carriage in a single cohort of pre and post-Hajj pilgrims from India. METHOD: A total of 3228 pre and post-Hajj, nasopharyngeal and oropharyngeal swabs were collected from 807 pilgrims with an interval of 40 ± 5 days...
April 3, 2018: Travel Medicine and Infectious Disease
Anwar M Hashem, Sayed S Sohrab, Sherif A El-Kafrawy, Adly M M Abd-Alla, Saeid Abo El-Ela, Turki S Abujamel, Ahmed M Hassan, Suha A Farraj, Noura A Othman, Remi N Charrel, Esam I Azhar
BACKGROUND: Dengue is the most important arboviral disease in tropical and subtropical countries. Dispersal of the vector and an increase in migratory flow between countries have led to large epidemics and severe clinical outcomes. Over the past 20 years, dengue epidemics have become more wide-spread and frequent. Previous studies have shown that dengue is endemic in Jeddah, Makkah and Al-Madinah in western Saudi Arabia as well as in Jazan region in the southern part of the country. The four serotypes of dengue virus (DENV) have been reported from western Saudi Arabia...
April 2, 2018: Acta Tropica
Zakeya A Bukhary, Soliman M Amer, Magdy M Emara, Mohammad E Abdalla, Sahar A Ali
BACKGROUND: Interferon gamma release assays (IGRA) is highly specific for Mycobacterium tuberculosis and is the preferred test in BCG-vaccinated individuals. The few studies that have screened health care workers (HCWs) in Saudi Arabia for latent tuberculosis infection (LTBI) using IGRA have varied in agreement with the traditional tuberculin skin test (TST). OBJECTIVE: Assess the prevalence of LTBI among HCWs working in the Hajj pilgrimage using IGRA and TST and measuring their agreement...
March 2018: Annals of Saudi Medicine
Hannah Rose, Manas Ghosh, Ailiena Maggiolo, Christopher J Pollock, Elizabeth J Blaesi, Viviane Hajj, Yifeng Wei, Lauren J Rajakovich, Wei-Chen Chang, Yilin Han, Mariana Hajj, Carsten Krebs, Alexey Silakov, Maria-Eirini Pandelia, J Martin Bollinger, Amie K Boal
A ribonucleotide reductase (RNR) from Flavobacterium johnsoniae (Fj) differs fundamentally from known (subclass a-c) class I RNRs, warranting its assignment to a new subclass, Id. Its β subunit shares with Ib counterparts the requirements for manganese(II) and superoxide for activation, but it does not require the superoxide-supplying flavoprotein (NrdI) needed in Ib systems, instead scavenging the oxidant from solution. Although Fj β has tyrosine at the appropriate sequence position (Tyr 104), this residue is not oxidized to a radical upon activation, as occurs in the Ia/b proteins...
April 2, 2018: Biochemistry
Chang-Il Kwon, Mark A Gromski, Hyoung-Chul Oh, Jeffrey J Easler, Ihab I El Hajj, James Watkins, Evan L Fogel, Lee McHenry, Stuart Sherman, Glen A Lehman
Background and study aims:  In plastic stent insertion for treatment of post-cholecystectomy bile leak, stent migration may be more common due to the absence of a shelf to anchor the stent. We evaluated how adding a flap to straight plastic stents for this indication might influence the rate of stent migration when compared to use of conventional plastic stents. Patients and methods:  This is a retrospective study including patients referred for ERCP for treatment of post-cholecystectomy bile leak...
April 2018: Endoscopy International Open
Fatme Mouchref Hamasni, Fady El Hajj, Rima Abdallah
This case report exhibits a patient with generalized aggressive periodontitis who has been under maintenance for the past 12 years after being surgically treated in a single sitting and restored with dental implants. A 41-year-old systemically healthy male patient presented complaining of lower anterior teeth mobility and pain in the upper right quadrant. After clinical and radiographic examination, the upper right molars and lower anterior incisors were deemed unrestorable. Covered by doxycycline, the patient received a nonsurgical periodontal treatment...
2018: Case Reports in Dentistry
Dana Maslovat, Joelle Hajj, Anthony N Carlsen
During reaction time (RT) tasks, participants respond faster to multiple stimuli from different modalities as compared to a single stimulus, a phenomenon known as the redundant signal effect (RSE). Explanations for this effect typically include coactivation arising from the multiple stimuli, which results in enhanced processing of one or more response production stages. The current study compared empirical RT data with the predictions of a model in which initiation-related activation arising from each stimulus is additive...
March 16, 2018: Neuroscience Letters
Mohammad Alfelali, Osamah Barasheed, Al-Mamoon Badahdah, Hamid Bokhary, Mohammed I Azeem, Turki Habeebullah, Marwan Bakarman, Atif Asghar, Robert Booy, Harunor Rashid
BACKGROUND: Hajj is the world's largest annual mass gathering that attracts two to three million Muslims from around the globe to a religious assemblage in Makkah, Saudi Arabia. The risk of acquisition and transmission of influenza among Hajj pilgrims is high. Therefore, influenza vaccination is recommended, and was monitored frequently among pilgrims from different countries. However, the vaccination uptake among Saudi pilgrims has not been assessed in recent years. OBJECTIVE: This analysis aims to evaluate influenza vaccine uptake among Saudi Hajj pilgrims, and identify the key barriers to vaccination...
March 16, 2018: Vaccine
Racha El-Hajj Ghaoui, Luke St Heaps, Dorothy Hung, Sumanth Nagabushan, Catherine Harris, Oksana Mirochnik, Praveen Sharma, Stewart J Kellie, Dale C Wright
Acute promyelocytic leukaemia with PML-RARA fusion is usually associated with the t(15;17)(q24.1;q21.1) translocation but may also arise from complex or cryptic rearrangements. The fusion usually resides on chromosome 15 but occasionally on others. We describe a cryptic PML-RARA fusion within a novel chromosome 17 rearrangement. We performed interphase fluorescence in situ hybridisation (FISH) using a dual-fusion PML-RARA probe, followed by reverse transcriptase-polymerase chain reaction (RT-PCR) for PML-RARA, karyotyping, and metaphase FISH using RARA break-apart, locus-specific, and subtelomere probes for chromosome 17...
March 17, 2018: Cytogenetic and Genome Research
Feride Taskin Yilmaz, Selma Sabanciogullari, Gulseren Karabey
This study was performed in order to determine the effect of Hajj pilgrimage on treatment compliance in individuals with chronic diseases. A total of 168 individuals were included in the prospective and descriptive study. Data were collected in three interviews using a patient identification form and the Religiousness Inclination Scale. When the medicine compliances of the individuals before and after Hajj pilgrimage were compared, a statistically meaningful difference between their regular uses of medicine statuses was found (p = 0...
March 14, 2018: Journal of Religion and Health
Christelle El Hajj Assaf, Selma Snini, Souria Tadrist, Sylviane Bailly, Claire Naylies, Isabelle P Oswald, Sophie Lorber, Olivier Puel
Penicillium expansum, the causal agent of the blue mold disease, produces the mycotoxins patulin and citrinin among other secondary metabolites. Secondary metabolism is associated with fungal development, which responds to numerous biotic and abiotic external triggers. The global transcription factor VeA plays a key role in the coordination of secondary metabolism and differentiation processes in many fungal species. The specific role of VeA in P. expansum remains unknown. A null mutant PeΔveA strain and a complemented PeΔveA:veA strain were generated in P...
March 8, 2018: Molecular Plant Pathology
Mohammed Shahait, Samer Nassif, Hani Tamim, Deborah Mukherji, Maya Hijazi, Marwan El Sabban, Raja Khauli, Muhammad Bulbul, Wassim Abou Kheir, Albert El Hajj
BACKGROUND: Positive surgical margin (PSM) is a predictor of biochemical recurrence (BCR) following radical prostatectomy (RP). Attempts to stratify PSM based on linear length, Gleason score, location and number have failed to add to predictive models using margin status alone. We evaluated the prognostic significance of Ki-67 expression in this setting. METHODS: Immunohistochemical staining for Ki-67 was done on prostatectomy specimens from 117 patients who had a PSM...
March 5, 2018: BMC Urology
Lubin Chen, Jianying Huang, Peng Zhao, Anna-Karin Persson, Fadia B Dib-Hajj, Xiaoyang Cheng, Andrew Tan, Stephen G Waxman, Sulayman D Dib-Hajj
Voltage-gated sodium channels NaV 1.7, NaV 1.8 and NaV 1.9 have been the focus for pain studies because their mutations are associated with human pain disorders, but the role of NaV 1.6 in pain is less understood. In this study, we selectively knocked out NaV 1.6 in dorsal root ganglion (DRG) neurons, using NaV 1.8-Cre directed or adeno-associated virus (AAV)-Cre mediated approaches, and examined the specific contribution of NaV 1.6 to the tetrodotoxin-sensitive (TTX-S) current in these neurons and its role in neuropathic pain...
March 1, 2018: Scientific Reports
Mha de Lima, Gnm Hajj, Vcc de Lima, F A Alves
A total of 115 patients who used everolimus were evaluated. The mean age was 57 (±13.3) years old, and 87 patients were women (75.6%). mTOR inhibitor-associated stomatitis (mIAS) was observed in 36 patients (31.3%). The lesions ranged from 0.5 cm to 1.5 cm, and the tongue was the main site affected. In addition, 21 patients (58.3%) required a dose reduction of everolimus due to mIAS. Patients who had breast cancer presented 2.29-fold higher risk for developing mIAS when compared to patients with kidney or neuroendocrine tumors...
March 2018: Oral Diseases
Ali AlBarrak, Badriah Alotaibi, Yara Yassin, Abdulaziz Mushi, Fuad Maashi, Yassein Seedahmed, Mohamed Alshaer, Abdulaziz Altaweel, Husameddin Elshiekh, Abdulhafiz Turkistani, Tanaz Petigara, John Grabenstein, Saber Yezli
BACKGROUND: The Hajj mass gathering is a risk for pneumococcal disease. We evaluated the proportion of adult community-acquired pneumonia (CAP) cases attributable to Streptococcus pneumoniae among Hajj pilgrims in 2016. To add sensitivity to etiologic attribution, we used a urine-antigen test, in addition to culture-based methods METHODS: Adults hospitalized with x-ray confirmed CAP were prospectively enrolled from all general hospitals designated to treat Hajj pilgrims in the holy cities of Mecca and Medina...
February 20, 2018: International Journal of Infectious Diseases: IJID
Chin W Hui, Abygaël St-Pierre, Hassan El Hajj, Yvan Remy, Sébastien S Hébert, Giamal N Luheshi, Lalit K Srivastava, Marie-Ève Tremblay
Epidemiological studies revealed that environmental factors comprising prenatal infection are strongly linked to risk for later development of neuropsychiatric disorders such as schizophrenia. Considering strong sex differences in schizophrenia and its increased prevalence in males, we designed a methodological approach to investigate possible sex differences in pathophysiological mechanisms. Prenatal immune challenge was modeled by systemic administration of the viral mimic polyinosinic-polycytidylic acid (Poly I:C) to C57BL/6 mice at embryonic day 9...
2018: Frontiers in Molecular Neuroscience
Jason Michael Springer, Paul Monach, David Cuthbertson, Simon Carette, Nader A Khalidi, Carol A McAlear, Christian Pagnoux, Philip Seo, Kenneth J Warrington, Steven R Ytterberg, Gary Hoffman, Carol Langford, Thomas Hamilton, Dirk Foell, Thomas Vogl, Dirk Holzinger, Peter A Merkel, Johannes Roth, Rula A Hajj-Ali
No abstract text is available yet for this article.
February 22, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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