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Ali AlBarrak, Badriah Alotaibi, Yara Yassin, Abdulaziz Mushi, Fuad Maashi, Yassein Seedahmed, Mohamed Alshaer, Abdulaziz Altaweel, Husameddin Elshiekh, Abdulhafiz Turkistani, Tanaz Petigara, John Grabenstein, Saber Yezli
BACKGROUND: The Hajj mass gathering is a risk for pneumococcal disease. We evaluated the proportion of adult community-acquired pneumonia (CAP) cases attributable to Streptococcus pneumoniae among Hajj pilgrims in 2016. To add sensitivity to etiologic attribution, we used a urine-antigen test, in addition to culture-based methods METHODS: Adults hospitalized with x-ray confirmed CAP were prospectively enrolled from all general hospitals designated to treat Hajj pilgrims in the holy cities of Mecca and Medina...
February 20, 2018: International Journal of Infectious Diseases: IJID
Chin W Hui, Abygaël St-Pierre, Hassan El Hajj, Yvan Remy, Sébastien S Hébert, Giamal N Luheshi, Lalit K Srivastava, Marie-Ève Tremblay
Epidemiological studies revealed that environmental factors comprising prenatal infection are strongly linked to risk for later development of neuropsychiatric disorders such as schizophrenia. Considering strong sex differences in schizophrenia and its increased prevalence in males, we designed a methodological approach to investigate possible sex differences in pathophysiological mechanisms. Prenatal immune challenge was modeled by systemic administration of the viral mimic polyinosinic-polycytidylic acid (Poly I:C) to C57BL/6 mice at embryonic day 9...
2018: Frontiers in Molecular Neuroscience
Jason Michael Springer, Paul Monach, David Cuthbertson, Simon Carette, Nader A Khalidi, Carol A McAlear, Christian Pagnoux, Philip Seo, Kenneth J Warrington, Steven R Ytterberg, Gary Hoffman, Carol Langford, Thomas Hamilton, Dirk Foell, Thomas Vogl, Dirk Holzinger, Peter A Merkel, Johannes Roth, Rula A Hajj-Ali
No abstract text is available yet for this article.
February 22, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Emile Abou Chaar, Souheil Hallit, Aline Hajj, Racha Aaraj, Joseph Kattan, Hicham Jabbour, Lydia Rabbaa Khabbaz
OBJECTIVE: Spiritual well-being was found to have some protective effect against end-of life despair in cancer patients. We aimed at assessing the impact of spirituality on the quality of life, depression, and anxiety of Lebanese cancer patients. METHODS: Our observational transversal monocentric study was conducted between January and April 2016 among a convenient sample of 115 Lebanese cancer patients admitted to Hôtel-Dieu de France Hospital (HDF), Beirut-Lebanon...
February 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Masoud Rahimian, Mahdi HosseiniB
No abstract text is available yet for this article.
February 10, 2018: Respiratory Medicine
Stephanie El Hajj, Sheldon E Litwin
No abstract text is available yet for this article.
February 6, 2018: Journal of Cardiac Failure
M C Dulac, C H Pion, F Lemieux, G Boutros El Hajj, M Belanger, P Gaudreau, S Chevalier, J A Morais, G Gouspillou, M Aubertin-Leheudre
INTRODUCTION: Normal aging is often associated with a decline of muscle mass (MM), strength (MS) and quality (MQ: MS/MM), leading to functional incapacities. This aging-related deterioration of muscles may involve a decreased protein intake. Mixed power training has been recently shown to induce positive effects on MM, MS and MQ. However, to our knowledge, no study has examined if muscle adaptations following mixed power training could be influenced by the daily amount of protein ingested in elderly men...
February 5, 2018: Experimental Gerontology
Raymond S W Tsang, Tauqeer Ahmad, Shaun Tyler, Brigitte Lefebvre, Shelley L Deeks, Rodica Gilca, Linda Hoang, Gregory Tyrrell, Paul Van Caeseele, Gary Van Domselaar, Frances B Jamieson
OBJECTIVE: We analyzed the Canadian invasive MenW ST-11 cc isolates by whole genome typing and compared Canadian isolates with similar isolates elsewhere. METHODS: Whole genome typing of 30 MenW ST-11 cc, 20 meningococcal group C (MenC) ST-11 cc and 31 MenW ST-22 cc isolates were carried out on the Bacterial Isolate Genome Sequence database platform. Canadian MenW ST-11 cc isolates were compared with the 2000 MenW Hajj outbreak strain, as well as with MenW ST-11 cc from other countries...
February 4, 2018: International Journal of Infectious Diseases: IJID
Anwar M Hashem, Esam I Azhar, Sarah Shalhoub, Turki S Abujamel, Norah A Othman, Abdulwahab B Al Zahrani, Hanan M Abdullah, Maha M Al-Alawi, Anees A Sindi
The emerged influenza A/H1N1pdm09 viruses have replaced the previously circulating seasonal H1N1 viruses. The close antigenic properties of these viruses to the 1918 H1N1 pandemic viruses and their post-pandemic evolution pattern could further enhance their adaptation and pathogenicity in humans representing a major public health threat. Given that data on the dynamics and evolution of these viruses in Saudi Arabia is sparse we investigated the genetic diversity of circulating influenza A/H1N1pdm09 viruses from Jeddah, Saudi Arabia, by analyzing 39 full genomes from isolates obtained between 2014-2015, from patients with varying symptoms...
February 2, 2018: Archives of Virology
Antonio Hernandez Conte, Jennifer Hajj, Stephen X Yang, Elizabeth Passano, Heather Barone, Dhilan A Thuraisingham, Jaime Moriguchi, Jon Kobashigawa, Francisco Arabia
No abstract text is available yet for this article.
December 2, 2017: Journal of Cardiothoracic and Vascular Anesthesia
Simone Albisinni, Fouad Aoun, Quentin Marcelis, Claude Jungels, Walid Al Hajj Obeid, Marc Zanaty, Andrea Tubaro, Thierry Roumeguere, Cosimo DE Nunzio
INTRODUCTION: The last decade has witnessed tremendous changes in the management of advanced and metastatic castration resistant prostate cancer (mCRPC). In the current systematic review, we analyze novel imaging techniques in the setting of recurrent and metastatic PCa, exploring available data and highlighting future exams which could enter clinical practice in the upcoming years. EVIDENCE ACQUISITION: The National Library of Medicine Database was searched for relevant articles published between January 2012 and August 2017...
January 31, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Jianying Huang, Malgorzata A Mis, Brian Tanaka, Talia Adi, Mark Estacion, Shujun Liu, Suellen Walker, Sulayman D Dib-Hajj, Stephen G Waxman
Sodium channel Nav1.7 plays a central role in pain-signaling: gain-of-function Nav1.7 mutations usually cause severe pain and loss-of-function mutations produce insensitivity to pain. The Nav1.7 I234T gain-of-function mutation, however, is linked to a dual clinical presentation of episodic pain, together with absence of pain following fractures, and corneal anesthesia. How a Nav1.7 mutation that produces gain-of-function at the channel level causes clinical loss-of-function has remained enigmatic. We show by current-clamp that expression of I234T in dorsal root ganglion (DRG) neurons produces a range of membrane depolarizations including a massive shift to >-40 mV that reduces excitability in a small number of neurons...
January 29, 2018: Scientific Reports
Hassan Pezeshgi Modarres, Mohsen Janmaleki, Mana Novin, John Saliba, Fatima El-Hajj, Mahdi RezayatiCharan, Amir Seyfoori, Hamid Sadabadi, Milène Vandal, Minh Dang Nguyen, Anwarul Hasan, Amir Sanati-Nezhad
The blood-brain barrier (BBB) plays a crucial role in maintaining brain homeostasis and transport of drugs to the brain. The conventional animal and Transwell BBB models along with emerging microfluidic-based BBB-on-chip systems have provided fundamental functionalities of the BBB and facilitated the testing of drug delivery to the brain tissue. However, developing biomimetic and predictive BBB models capable of reasonably mimicking essential characteristics of the BBB functions is still a challenge. In addition, detailed analysis of the dynamics of drug delivery to the healthy or diseased brain requires not only biomimetic BBB tissue models but also new systems capable of monitoring the BBB microenvironment and dynamics of barrier function and delivery mechanisms...
January 25, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Philippe Gatault, Sally Al-Hajj, Johan Noble, Eloi Chevallier, Marie Piollet, Catherine Forconi, Catherine Gaudy-Graffin, Gilles Thibault, Elodie Miquelestorena-Standley, Jean Michel Halimi, Matthias Büchler, Roxane Lemoine, Christophe Baron
We aimed to determine the role of cytomegalovirus (CMV)-infected donor cells in the development of a CMV-specific immune response in kidney transplant recipients. We assessed the CMV pp65-specific immune response by using interferon-ɣ ELISPOT and dextramers in peripheral blood mononuclear cells from 115 recipients (D+R- 31, D+R+ 44, D-R+ 40) late after transplantation (mean 59±42 months). Receiving a kidney from a D+ donor resulted in a higher number of IFN-ɣ-producing anti-CMV T-cells (p=0.004). This effect disappeared with the absence of shared HLA class I specificities between donors and recipients (p=0...
January 27, 2018: American Journal of Transplantation
Antoine El Asmar, Yasmine Papas, Imad Hajj, Mansour El Khoury
The approach to toothpick ingestion and its complications should not be underestimated. The surgeon should be prepared for life-threatening situations such as major vascular involvement, as well as highly specialized and technically challenging procedures, when the hepatic hilum is involved for instance. Referral to tertiary centers is sometimes mandatory.
January 2018: Clinical Case Reports
Yang Yang, Malgorzata A Mis, Mark Estacion, Sulayman D Dib-Hajj, Stephen G Waxman
Chronic pain is a global unmet medical need. Most existing treatments are only partially effective or have side effects that limit their use. Rapid progress in elucidating the contribution of specific genes, including those that encode peripheral voltage-gated sodium channels, to the pathobiology of chronic pain suggests that it may be possible to advance pain pharmacotherapy. Focusing on voltage-gated sodium channel NaV1.7 as an example, this article reviews recent progress in developing patient-specific induced pluripotent stem cells (iPSCs) and their differentiation into sensory neurons, together with advances in structural modeling, that have provided a basis for first-in-human translational studies...
January 19, 2018: Trends in Pharmacological Sciences
Tania Winzenberg, Christel Lamberg-Allardt, Ghada El-Hajj Fuleihan, Christian Mølgaard, Kun Zhu, Feitong Wu, Richard D Riley
INTRODUCTION: Our previous study-level (aggregate data) meta-analysis suggested that vitamin D supplements may be beneficial for bone density specifically in children with vitamin D deficiency. However, the misclassification of vitamin D status inherent in study-level data means that the results are not definitive and cannot provide an accurate assessment of the size of any effect. Therefore, we propose to undertake an individual patient data (IPD) meta-analysis to determine whether the effect of vitamin D supplementation on bone density in children differs according to baseline vitamin D status, and to specifically estimate the effect of vitamin D in children who are vitamin D deficient...
January 23, 2018: BMJ Open
Saad Mahmud Khan, Sarah El Hajj Chehadeh, Mehera Abdulrahman, Wael Osman, Habiba Al Safar
BACKGROUND: Obesity is a metabolic disease that is widely prevalent with approximately 600 million people classified as obese worldwide. Its etiology is multifactorial and involves a complex interplay between genes and the environment. Over the past few decades, obesity rates among the Emirati population have been increasing. The aim of this study was to investigate the association of candidate gene single nucleotide polymorphisms (SNPs), namely FTO (rs9939609) and VDR (rs1544410), with obesity in the UAE population...
January 17, 2018: BMC Medical Genetics
A K M Muraduzzaman, Manjur Hossain Khan, Rezina Parveen, Sharmin Sultana, Ahmed Nawsher Alam, Arifa Akram, Mahmudur Rahman, Tahmina Shirin
INTRODUCTION: Every year around 150,000 pilgrims from Bangladesh perform Umrah and Hajj. Emergence and continuous reporting of MERS-CoV infection in Saudi Arabia emphasize the need for surveillance of MERS-CoV in returning pilgrims or travelers from the Middle East and capacity building of health care providers for disease containment. The Institute of Epidemiology, Disease Control & Research (IEDCR) under the Bangladesh Ministry of Health and Family welfare (MoHFW), is responsible for MERS-CoV screening of pilgrims/ travelers returning from the Middle East with respiratory illness as part of its outbreak investigation and surveillance activities...
2018: PloS One
Luis Eduardo Machado, Arthur William Alvarenga, Fernanda Ferreira da Silva, Martín Roffé, Maria Dirlei Begnami, Luís Fernando Bleggi Torres, Isabela Werneck da Cunha, Vilma Regina Martins, Glaucia Noeli Maroso Hajj
PI3K/Akt/mTOR pathway activation is a hallmark of high-grade gliomas, which prompted clinical trials for the use of PI3K and mTOR inhibitors. However, the poor results in the original trials suggested that better patient profiling was needed for such drugs. Thus, accurate and reproducible monitoring of mTOR complexes can lead to improved therapeutic strategies. In this work, we evaluated the expression and phosphorylation of mTOR, RAPTOR, and rpS6 in 195 human astrocytomas and 30 normal brain tissue samples...
January 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
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