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https://www.readbyqxmd.com/read/28549141/risk-factors-for-acquisition-of-ctx-m-genes-in-pilgrims-during-hajj-2013-and-2014
#1
Thongpan Leangapichart, Hervé Tissot-Dupont, Didier Raoult, Ziad A Memish, Jean-Marc Rolain, Philippe Gautret
Background: Mass gatherings, especially the Hajj pilgrimage, provide favourable conditions for bacterial transmission among participants, which might contribute to the international spread of ESBL-producing Enterobacteriaceae (ESBL-E). Objectives: We conducted an analysis aimed at investigating risk factors for CTX-M gene ( bla CTX-M ) rectal carriage in 2013 and 2014 Hajj pilgrims. Methods: A total of 218 pilgrims provided paired pre- and post-Hajj rectal samples (2013, 129 pilgrims; 2014, 89 pilgrims)...
May 26, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28548111/corrigendum-pharmacological-characterisation-of-the-highly-nav1-7-selective-spider-venom-peptide-pn3a
#2
Jennifer R Deuis, Zoltan Dekan, Joshua S Wingerd, Jennifer J Smith, Nehan R Munasinghe, Rebecca F Bhola, Wendy L Imlach, Volker Herzig, David A Armstrong, K Johan Rosengren, Frank Bosmans, Stephen G Waxman, Sulayman D Dib-Hajj, Pierre Escoubas, Michael S Minett, Macdonald J Christie, Glenn F King, Paul F Alewood, Richard J Lewis, John N Wood, Irina Vetter
No abstract text is available yet for this article.
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28542529/associations-between-quality-of-life-physical-activity-worry-depression-and-insomnia-a-cross-sectional-designed-study-in-healthy-pregnant-women
#3
Danielle Mourady, Sami Richa, Rita Karam, Tatiana Papazian, Fabienne Hajj Moussa, Nada El Osta, Assaad Kesrouani, Joseph Azouri, Hicham Jabbour, Aline Hajj, Lydia Rabbaa Khabbaz
Health-related quality of life (QOL) is reported to be reduced during pregnancy. Associations between QOL, physical activity (PA), insomnia, depression and worry are insufficiently investigated among pregnant women. The aim of this study was to evaluate QOL and PA patterns among healthy pregnant women, and to examine how QOL might correlate to PA, sleep, worry and depression. This is an observational cross-sectional study, conducted among a convenient sample of 141 healthy pregnant women using five questionnaires: WHOQOL-brief (WHO quality of life questionnaire, brief version, ISI (Insomnia Severity Index), PSWQ (Penn State Worry Questionnaire), ZSRDS (Zung Self-Rating Depression Scale), and Pregnancy Physical Activity Questionnaire (PPAQ)...
2017: PloS One
https://www.readbyqxmd.com/read/28530638/sodium-channel-nav1-9-mutations-associated-with-insensitivity-to-pain-dampen-neuronal-excitability
#4
Jianying Huang, Carlos G Vanoye, Alison Cutts, Y Paul Goldberg, Sulayman D Dib-Hajj, Charles J Cohen, Stephen G Waxman, Alfred L George
Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on NaV1.7 and NaV1.8 established clear relationships between perturbations in channel function and divergent clinical phenotypes. By contrast, studies of NaV1.9 mutations have not revealed a clear relationship of channel dysfunction with the associated and contrasting clinical phenotypes. Here, we have elucidated the functional consequences of a NaV1...
May 22, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28508371/efficient-and-accurate-algorithm-for-cleaved-fragments-prediction-cfpa-in-protein-sequences-dataset-based-on-consensus-and-its-variants-a-novel-degradomics-prediction-application
#5
Atlal El-Assaad, Zaher Dawy, Georges Nemer, Hazem Hajj, Firas H Kobeissy
Degradomics is a novel discipline that involves determination of the proteases/substrate fragmentation profile, called the substrate degradome, and has been recently applied in different disciplines. A major application of degradomics is its utility in the field of biomarkers where the breakdown products (BDPs) of different protease have been investigated. Among the major proteases assessed, calpain and caspase proteases have been associated with the execution phases of the pro-apoptotic and pro-necrotic cell death, generating caspase/calpain-specific cleaved fragments...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28468249/unconventional-secretion-of-heat-shock-proteins-in-cancer
#6
REVIEW
Tiago Góss Santos, Vilma Regina Martins, Glaucia Noeli Maroso Hajj
Heat shock proteins (HSPs) are abundant cellular proteins involved with protein homeostasis. They have both constitutive and inducible isoforms, whose expression levels are further increased by stress conditions, such as temperature elevation, reduced oxygen levels, infection, inflammation and exposure to toxic substances. In these situations, HSPs exert a pivotal role in offering protection, preventing cell death and promoting cell recovery. Although the majority of HSPs functions are exerted in the cytoplasm and organelles, several lines of evidence reveal that HSPs are able to induce cell responses in the extracellular milieu...
April 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28460030/subcutaneous-cardioverter-defibrillator-has-longer-time-to-therapy-but-is-less-cardiotoxic-than-transvenous-cardioverter-defibrillator-study-carried-out-in-a-preclinical-porcine-model
#7
Rodrigue Garcia, Sofiane Inal, Frederic Favreau, Christophe Jayle, Thierry Hauet, Patrick Bruneval, Thomas Kerforne, Jamil Hajj-Chahine, Bruno Degand
Aims: Totally subcutaneous implantable cardioverter defibrillator (S-ICD) delivers higher shock energy and can have longer time to therapy compared to transvenous implantable cardioverter defibrillator (T-ICD). Aim of the study was to compare time to therapy and to investigate cardiac, cerebral and systemic injuries of S-ICD and T-ICD shocks delivered after ventricular fibrillation (VF) induction. Methods and results: Fourteen pigs were randomly implanted with a S-ICD (n = 7) or a T-ICD (n = 7)...
April 27, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28455205/meningococcal-disease-in-the-middle-east-and-africa-findings-and-updates-from-the-global-meningococcal-initiative
#8
REVIEW
Ray Borrow, Dominique A Caugant, Mehmet Ceyhan, Hannah Christensen, Ener Cagri Dinleyici, Jamie Findlow, Linda Glennie, Anne Von Gottberg, Amel Kechrid, Julio Vázquez Moreno, Aziza Razki, Vincent Smith, Muhamed-Kheir Taha, Hassiba Tali-Maamar, Khalid Zerouali
The Global Meningococcal Initiative (GMI) has recently considered current issues in Middle Eastern and African countries, and produced two recommendations: (i) that vaccination of attendees should be considered for some types of mass-gathering events, as some countries mandate for the Hajj, and (ii) vaccination of people with human immunodeficiency virus should be used routinely, because of increased meningococcal disease (MD) risk. Differences exist between Middle Eastern and African countries regarding case and syndrome definitions, surveillance, and epidemiologic data gaps...
April 25, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28455183/the-effects-of-competition-and-implicit-power-motive-on-men-s-testosterone-emotion-recognition-and-aggression
#9
John G Vongas, Raghid Al Hajj
A contribution to a special issue on Hormones and Human Competition. We investigated the effects of competition on men's testosterone levels and assessed whether androgen reactivity was associated with subsequent emotion recognition and reactive and proactive aggression. We also explored whether personalized power (p Power) moderated these relationships. In Study 1, 84 males competed on a number tracing task and interpreted emotions from facial expressions. In Study 2, 72 males competed on the same task and were assessed on proactive and reactive aggression...
April 25, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28403940/vitamin-d-replacement-in-children-adolescents-and-pregnant-women-in-the-middle-east-and-north-africa-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
REVIEW
Marlene Chakhtoura, Sara El Ghandour, Khaled Shawwa, Elie A Akl, Asma Arabi, Ziyad Mahfoud, Robert Habib, Hassan Hoballah, Ghada El Hajj Fuleihan
INTRODUCTION: Hypovitaminosis D affects one-third to two-thirds of children and pregnant women from the Middle East and North Africa (MENA) region. OBJECTIVE: To evaluate in infants, children, adolescents and pregnant women, from the MENA region, the effect of supplementation with different vitamin D doses on the change in 25-hydroxyvitamin D [25(OH)D] level reached, and other skeletal and non-skeletal outcomes. METHODS: This is a systematic review of randomized controlled trials of vitamin D supplementation conducted in the MENA region...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28400457/emergency-nurse-disaster-preparedness-during-mass-gatherings-a-cross-sectional-survey-of-emergency-nurses-perceptions-in-hospitals-in-mecca-saudi-arabia
#11
Fuad Alzahrani, Kyratsis Yiannis
OBJECTIVES: To assess hospital emergency nurses' self-reported knowledge, role awareness and skills in disaster response with respect to the Hajj mass gathering in Mecca. DESIGN: Cross-sectional online survey with primary data collection and non-probabilistic purposive sample conducted in late 2014. SETTING: All 4 public hospitals in Mecca, Saudi Arabia. PARTICIPANTS: 106 registered nurses in hospital emergency departments...
April 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28381558/gain-of-function-mutation-of-a-voltage-gated-sodium-channel-nav1-7-associated-with-peripheral-pain-and-impaired-limb-development
#12
Brian S Tanaka, Phuong T Nguyen, Eray Yihui Zhou, Yong Yang, Vladimir Yarov-Yarovoy, Sulayman D Dib-Hajj, Stephen G Waxman
Dominant mutations in voltage-gated sodium channel NaV1.7 cause inherited erythromelalgia (IEM), a debilitating pain disorder characterized by severe burning pain and redness of the distal extremities. NaV1.7 is preferentially expressed within peripheral sensory and sympathetic neurons. Here, we describe a novel NaV1.7 mutation in an 11-year old male with under-development of the limbs, recurrent attacks of burning pain with erythema and swelling in his feet and hands. Frequency and duration of the episodes gradually increased with age and relief by cooling became less effective...
April 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28375507/tetanus-diphtheria-pertussis-vaccine-may-suppress-the-immune-response-to-subsequent-immunization-with-pneumococcal-crm197-conjugate-vaccine-coadministered-with-quadrivalent-meningococcal-tt-conjugate-vaccine-a-randomized-controlled-trial%C3%A2
#13
Mohamed Tashani, Leon Heron, Melanie Wong, Harunor Rashid, Robert Booy
Background: : Due to their antigenic similarities, there is a potential for immunological interaction between tetanus/diphtheria-containing vaccines and carrier proteins presented on conjugate vaccines. The interaction could, unpredictably, result in either enhancement or suppression of the immune response to conjugate vaccines if they are injected soon after or concurrently with diphtheria or tetanus toxoid. We examined this interaction among adult Australian travellers before attending the Hajj pilgrimage of 2015...
July 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28373319/erratum-for-el-hajj-fuleihan-et-al-effect-of-vitamin-d-replacement-on-indexes-of-insulin-resistance-in-overweight-elderly-individuals-a-randomized-controlled-trial-am-j-clin-nutr-2016-104-315-23
#14
(no author information available yet)
No abstract text is available yet for this article.
April 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28360945/epigenetic-signatures-of-gestational-diabetes-mellitus-on-cord-blood-methylation
#15
Larissa Haertle, Nady El Hajj, Marcus Dittrich, Tobias Müller, Indrajit Nanda, Harald Lehnen, Thomas Haaf
BACKGROUND: Intrauterine exposure to gestational diabetes mellitus (GDM) confers a lifelong increased risk for metabolic and other complex disorders to the offspring. GDM-induced epigenetic modifications modulating gene regulation and persisting into later life are generally assumed to mediate these elevated disease susceptibilities. To identify candidate genes for fetal programming, we compared genome-wide methylation patterns of fetal cord bloods (FCBs) from GDM and control pregnancies...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28355612/strengthening-health-security-at-the-hajj-mass-gatherings-characteristics-of-the-infectious-diseases-surveillance-systems-operational-during-the-2015-hajj
#16
Badriah M Alotaibi, Saber Yezli, Abdul-Aziz A Bin Saeed, Abdulhafeez Turkestani, Amnah H Alawam, Kingsley L Bieh
Background: Hajj is one of the largest and the most ethnically and culturally diverse mass gatherings worldwide. The use of appropriate surveillance systems ensures timely information management for effective planning and response to infectious diseases threats during the pilgrimage. The literature describes infectious diseases prevention and control strategies for Hajj but with limited information on the operations and characteristics of the existing Hajj infectious diseases surveillance systems...
May 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28352634/surveillance-of-australian-hajj-pilgrims-for-carriage-of-potentially-pathogenic-bacteria-data-from-two-pilot-studies
#17
Mohammad Irfan Azeem, Mohamed Tashani, Al-Mamoon Badahdah, Leon Heron, Kristen Pedersen, Neisha Jeoffreys, Jen Kok, Elizabeth Haworth, Dominic E Dwyer, Grant Hill-Cawthorne, Harunor Rashid, Robert Booy
AIM: To estimate the pharyngeal carriage rate of Neisseria meningitidis (N. meningitidis), Streptococcus pneumoniae (S. pneumoniae) and Staphylococcus aureus (S. aureus) among Australian Hajj pilgrims. METHODS: In 2014, surveillance was conducted in two phases among Australian Hajj pilgrims: The first phase during Hajj in Mina, and the second phase soon after returning home to Australia. Nasopharyngeal or oropharyngeal swabs were taken from participants then tested, firstly by nucleic acid testing, and also by standard culture...
March 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28349461/high-throughput-mapping-of-2-o-me-residues-in-rna-using-next-generation-sequencing-illumina-ribomethseq-protocol
#18
Virginie Marchand, Lilia Ayadi, Aseel El Hajj, Florence Blanloeil-Oillo, Mark Helm, Yuri Motorin
Detection of RNA modifications in native RNAs is a tedious and laborious task, since the global level of these residues is low and most of the suitable physico-chemical methods require purification of the RNA of interest almost to homogeneity. To overcome these limitations, methods based on RT-driven primer extension have been developed and successfully used, sometimes in combination with a specific chemical treatment. Nowadays, some of these approaches have been coupled to high-throughput sequencing technologies, allowing the access to transcriptome-wide data...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28346387/oprm1-c-118a-g-polymorphism-and-duration-of-morphine-treatment-associated-with-morphine-doses-and-quality-of-life-in-palliative-cancer-pain-settings
#19
Aline Hajj, Lucine Halepian, Nada El Osta, Georges Chahine, Joseph Kattan, Lydia Rabbaa Khabbaz
Despite increased attention on assessment and management, pain remains the most persistent symptom in patients with cancer, in particular in end-of-life settings, with detrimental impact on their quality-of-life (QOL). We conducted this study to evaluate the added value of determining some genetic and non-genetic factors to optimize cancer pain treatment. Eighty-nine patients were included in the study for the evaluation of palliative cancer pain management. The regression analysis showed that age, OPRM1 single nucleotide polymorphism (SNP), as well as the duration of morphine treatment were significantly associated with morphine doses at 24 h (given by infusion pump; p = 0...
March 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28343777/neisseria-meningitidis-nasopharyngeal-carriage-during-the-hajj-a-cohort-study-evaluating-the-need-for-ciprofloxacin-prophylaxis
#20
Ziad A Memish, Jaffar A Al-Tawfiq, Malak Almasri, Esam I Azhar, Muhammad Yasir, Muneera S Al-Saeed, Huda Ben Helaby, Ray Borrow, Abdulhafeez Turkistani, Abdallah Assiri
BACKGROUND: The annual Muslim pilgrimage has the potential of increase risk for acquisition of Neisseria meningitidis. Here, we evaluate the Hajj impact on the prevalence of N. meningitidis carriage in a paired and non-paired cohort of pilgrims. Secondary objectives were to calculate the compliance with recommended vaccination. METHODS: This is a prospective paired (arriving and departing), non-paired arriving and non-paired departing cohort study with the collection of nasopharyngeal samples at the start and the end of the Hajj...
March 23, 2017: Vaccine
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