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A Positive Diagnostic Strategy Is Noninferior to a Strategy of Exclusion for Patients With Irritable Bowel Syndrome

Luise M Begtrup, Anne Line Engsbro, Jens Kjeldsen, Pia V Larsen, Ove Schaffalitzky de Muckadell, Peter Bytzer, Dorte E Jarbøl
BACKGROUND & AIMS: Guidelines recommend a positive strategy based on symptom criteria to diagnose patients with irritable bowel syndrome (IBS). We conducted a randomized noninferiority trial to determine whether a positive diagnostic strategy is noninferior to a strategy of exclusion, with regard to patients' health-related quality of life (HRQOL). METHODS: We studied 302 patients (18-50 years old) from primary care who were suspected of having IBS and referred by general practitioners...
August 2013: Clinical Gastroenterology and Hepatology
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