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https://www.readbyqxmd.com/read/29052797/suppressive-antibiotic-therapy-with-oral-tetracyclines-for-prosthetic-joint-infections-a-retrospective-study-of-78-patients
#1
M Pradier, O Robineau, A Boucher, M Titecat, N Blondiaux, M Valette, C Loïez, E Beltrand, S Nguyen, H Dézeque, H Migaud, Eric Senneville
PURPOSE: This study aimed at describing the use of oral cyclines (i.e., doxycycline and minocycline) as suppressive antibiotic therapy (SAT) in patients with periprosthetic joint infections (PJIs). METHODS: Medical charts of all patients with surgical revisions for PJIs who were given cycline-based SAT because of a high failure of various origins were reviewed. Data regarding tolerability and effectiveness of cycline-based SAT were analysed. RESULTS: Seventy-eight patients of mean age 64 ± 17 years received cycline-base SAT in the period from January 2006 to January 2014...
October 20, 2017: Infection
https://www.readbyqxmd.com/read/29051615/time-controllable-nkcc1-knockdown-replicates-reversible-hearing-loss-in-postnatal-mice
#2
Takahisa Watabe, Ming Xu, Miho Watanabe, Junichi Nabekura, Taiga Higuchi, Karin Hori, Mitsuo P Sato, Fumiaki Nin, Hiroshi Hibino, Kaoru Ogawa, Masatsugu Masuda, Kenji F Tanaka
Identification of the causal effects of specific proteins on recurrent and partially reversible hearing loss has been difficult because of the lack of an animal model that provides reversible gene knockdown. We have developed the transgenic mouse line Actin-tTS::Nkcc1 (tetO/tetO) for manipulatable expression of the cochlear K(+) circulation protein, NKCC1. Nkcc1 transcription was blocked by the binding of a tetracycline-dependent transcriptional silencer to the tetracycline operator sequences inserted upstream of the Nkcc1 translation initiation site...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051279/expansion-of-epor-negative-macrophages-besides-erythroblasts-by-elevated-epor-signaling-in-erythrocytosis-mouse-models
#3
Jieyu Wang, Yoshihiro Hayashi, Asumi Yokota, Zefeng Xu, Yue Zhang, Rui Huang, Xiaomei Yan, Hongyun Liu, Liping Ma, Mohammad Azam, James P Bridges, Jose A Cancelas, Theodosia A Kalfa, Xiuli An, Zhijian Xiao, Gang Huang
Activated EPO receptor (EPOR) signaling causes erythrocytosis. The important role of macrophages for the erythroid expansion and differentiation process has been reported, both in baseline and stress erythropoiesis. However, the significance of EPOR signaling for regulation of macrophages contributing to erythropoiesis has not been fully understood. Here we show that EPOR signaling activation quickly expands both erythrocytes and macrophages in vivo in mouse models of primary and secondary erythrocytosis. To mimic the chimeric condition and expansion of the disease clone in the polycythemia vera patients, we combined Cre-inducible Jak2V617F/+ allele with LysM-Cre allele which expresses in mature myeloid cells and some of the HSC/Ps (LysM-Cre;Jak2V617F/+ mice)...
October 19, 2017: Haematologica
https://www.readbyqxmd.com/read/29050793/anaplasmosis-in-pediatric-patients-case-report-and-review
#4
Vaka K Sigurjonsdottir, Henry M Feder, Gary P Wormser
Human granulocytic anaplasmosis (HGA) is a tick-borne infection, characterized as an acute and sometimes severe febrile illness which may be associated with leukopenia and thrombocytopenia. Most case reports of HGA have been in adults, with only 8 case reports of HGA in children. We add a ninth case of HGA, which occurred in a 5-year-old. The paucity of pediatric HGA case reports maybe because publication bias, or HGA in children is a mild illness and children with HGA are less likely than adults to seek medical care, or the diagnosis of HGA requires a blood draw and adults (versus children) are more likely to get diagnostic testing...
November 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29047253/percutaneous-drainage-and-povidone-iodine-sclerotherapy-of-cervical-lymphatic-malformation
#5
Seung Hyoung Kim, Mu Sook Lee, Gil Chai Lim, Chan Il Song
Lymphatic malformations in cases with macrocystic lesions can be treated with surgical excision or sclerotherapy using alcohol, bleomycin, doxycycline, or OK-432. We report a case of a 24-year-old woman who underwent percutaneous drainage and povidone-iodine sclerotherapy as primary treatment for cervical lymphatic malformation. The patient underwent povidone-iodine sclerotherapy for 3 consecutive days. After 8 months, ultrasonography of the lesion in the neck revealed complete resolution of the cervical lymphatic malformation without any complication...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29045563/generation-of-transgenic-marmosets-using-a-tetracyclin-inducible-transgene-expression-system-as-a-neurodegenerative-disease-model
#6
Ikuo Tomioka, Naotake Nogami, Terumi Nakatani, Kensuke Owari, Naoko Fujita, Hideyuki Motohashi, Osamu Takayama, Kentaro Takae, Yoshitaka Nagai, Kazuhiko Seki
Controllable transgene expression systems are indispensable tools for the production of animal models of disease to investigate protein functions at defined periods. However, in non-human primates that share genetic, physiological, and morphological similarities with humans, genetic modification techniques have not been well established; therefore, the establishment of novel transgenic models with controllable transgene expression systems will be valuable tools to understand pathological mechanism of human disease...
October 13, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29044097/dna-binding-of-the-tet-transactivator-curtails-antigen-induced-lymphocyte-activation-in-mice
#7
Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J Herold, Andreas Strasser, Andreas Villunger
The Tet-On/Off system for conditional transgene expression constitutes state-of-the-art technology to study gene function by facilitating inducible expression in a timed and reversible manner. Several studies documented the suitability and versatility of this system to trace lymphocyte fate and to conditionally express oncogenes or silence tumour suppressor genes in vivo. Here, we show that expression of the tetracycline/doxycycline-controlled Tet-transactivator, while tolerated well during development and in immunologically unchallenged animals, impairs the expansion of antigen-stimulated T and B cells and thereby curtails adaptive immune responses in vivo...
October 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/29044082/rickettsial-retinitis-direct-bacterial-infection-or-an-immune-mediated-response
#8
Rohan Chawla, Gadkar Amit Pundlik, Rama Chaudhry, Chandan Thakur
Infectious retinitis postfebrile illness is known to be caused by chikungunya, dengue, West Nile virus, Bartonella, Lyme's disease, Rift Valley fever, rickettsia, Herpes viruses etc. Rickettsia is Gram-negative bacteria transmitted by arthropods vectors. Ocular involvement is common including conjunctivitis, keratitis, anterior uveitis, panuveitis, retinitis, retinal vascular changes, and optic nerve involvement. Retinitis lesions in rickettsia can occur because of an immunological response to the bacteria or because of direct invasion and proliferation of bacteria in the inner retina...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29042680/sperm-borne-mir-449b-influences-cleavage-epigenetic-reprogramming-and-apoptosis-of-scnt-embryos-in-bovine
#9
Mengyun Wang, Yang Gao, Pengxiang Qu, Suzhu Qing, Fang Qiao, Yong Zhang, Jesse Mager, Yongsheng Wang
Accumulating evidence indicates the absence of paternally derived miRNAs, piwiRNAs, and proteins may be one important factor contributing to developmental failure in somatic cell cloned embryos. In the present study, we found microRNA-449b (miR-449b) was highly expressed in sperm. Target gene predictions and experimental verification indicate that several embryonic development-related genes, including CDK6, c-MYC, HDAC1 and BCL-2, are targets of miR-449b. We therefore investigated the role of miR-449b using somatic cell nuclear transfer (SCNT) embryo model...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040431/prevention-of-breast-cancer-induced-osteolytic-bone-resorption-by-benzyl-isothiocyanate
#10
Subrata K Pore, Eun-Ryeong Hahm, Joseph D Latoche, Carolyn J Anderson, Yongli Shuai, Shivendra V Singh
Osteolytic bone resorption is the primary cause of pain and suffering (e.g., pathological bone fracture) in women with metastatic breast cancer. The current standard of care for patients with bone metastasis for reducing the incidence of skeletal complications includes bisphosphonates and a humanized antibody (denosumab). However, a subset of patients on these therapies still develops new bone metastasis or experience adverse effects. Moreover, some bisphosphonates have poor oral bioavailability. Therefore, orally-bioavailable and non-toxic inhibitors of breast cancer-induced osteolytic bone resorption are still clinically desirable...
October 11, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29040203/the-temporal-response-and-mechanism-of-action-of-tranexamic-acid-in-endothelial-glycocalyx-degradation
#11
Mark E Diebel, Jonathan V Martin, David M Liberati, Lawrence N Diebel
BACKGROUND: The endothelial glycocalyx (GCX) plays an important role in vascular barrier function. Damage to the GCX occurs due to a variety of causes including hypoxia, ischemia-reperfusion, stress related sympathoadrenal activation, and inflammation. Tranexamic acid (TXA) may prevent GCX degradation. The therapeutic window for TXA administration and the mechanism of action has been under review. Membrane-anchored proteases (sheddases) are key components in endothelial cell biology including the regulation of vascular permeability...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29036702/a-hyperdynamic-h3-3-nucleosome-marks-promoter-regions-in-pluripotent-embryonic-stem-cells
#12
Sharon Schlesinger, Binyamin Kaffe, Shai Melcer, Jose D Aguilera, Divya M Sivaraman, Tommy Kaplan, Eran Meshorer
Histone variants and their chaperones are key regulators of eukaryotic transcription, and are critical for normal development. The histone variant H3.3 has been shown to play important roles in pluripotency and differentiation, and although its genome-wide patterns have been investigated, little is known about the role of its dynamic turnover in transcriptional regulation. To elucidate the role of H3.3 dynamics in embryonic stem cell (ESC) biology, we generated mouse ESC lines carrying a single copy of a doxycycline (Dox)-inducible HA-tagged version of H3...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29036565/long-term-risk-of-acute-myocardial-infarction-stroke-and-death-with-outpatient-use-of-clarithromycin-a-retrospective-cohort-study
#13
Andrew D Mosholder, Joo-Yeon Lee, Esther H Zhou, Elizabeth M Kang, Mayurika Ghosh, Rima Izem, Jacqueline M Major, David J Graham
This retrospective cohort study of subjects enrolled in the United Kingdom Clinical Practice Research Datalink from 2000-2013 evaluated long-term risks of death, stroke, and acute myocardial infarction (AMI) in adults prescribed clarithromycin. Subjects were outpatients aged 40-85 years prescribed clarithromycin, doxycycline, or erythromycin (287,748, 267,729, and 442,999 patients, respectively), or H. pylori eradication therapy with a proton pump inhibitor, amoxicillin, and either clarithromycin (27,639 patients) or metronidazole (14,863 patients)...
September 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29036520/lung-specific-overexpression-of-constitutively-active-ikk2-induces-pulmonary-and-systemic-inflammations-but-not-hypothalamic-inflammation-and-glucose-intolerance
#14
Minjie Chen, Huifen Zhou, Yanyi Xu, Lianglin Qiu, Ziying Hu, Xiaobo Qin, Sufang Chen, Yuhao Zhang, Qi Cao, Yousef Abu-Amer, Zhekang Ying
The lung is constantly exposed to ambient pollutants such as ambient fine particulate matter (PM2.5), making it one of the most frequent locations of inflammation in the body. Given the establishment of crucial role of inflammation in the pathogenesis of cardiometabolic diseases, pulmonary inflammation is thus widely believed to be an important risk factor for cardiometabolic diseases. However, the causality between them has not yet been well established. To determine if pulmonary inflammation is sufficient to cause adverse cardiometabolic effects, SFTPC-rtTA+/-tetO-cre+/-pROSA-inhibitor κB kinase 2(IKK2)ca+/- (LungIKK2ca) and littermate SFTPC-rtTA+/-tetO-cre-/-pROSA-IKK2ca+/- wildtype (WT) mice were fed with doxycycline diet to induce constitutively active Ikk2 (Ikk2ca) overexpression in the lung and their pulmonary, systemic, adipose, and hypothalamic inflammations, vascular function, and glucose homeostasis were assessed...
July 28, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29036355/design-and-implementation-of-a-synthetic-pre-mir-switch-for-controlling-mirna-biogenesis-in-mammals
#15
Janina Atanasov, Florian Groher, Julia E Weigand, Beatrix Suess
Synthetic RNA-based systems have increasingly been used for the regulation of eukaryotic gene expression. Due to their structural properties, riboregulators provide a convenient basis for the development of ligand-dependent controllable systems. Here, we demonstrate reversible conditional control of miRNA biogenesis with an aptamer domain as a sensing unit connected to a natural miRNA precursor for the first time. For the design of the pre-miR switch, we replaced the natural terminal loop with the TetR aptamer...
September 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29034777/effects-of-matrix-metalloproteinase-inhibitor-doxycycline-and-cd147-antagonist-peptide-9-on-gallbladder-carcinoma-cell-lines
#16
Shihang Wang, Chao Liu, Xinjiang Liu, Yanxin He, Dongfang Shen, Qiankun Luo, Yuxi Dong, Haifeng Dong, Zhigang Pang
Gallbladder carcinoma is the most common and aggressive malignancy of the biliary tree and highly expresses CD147, which is closely related to disease prognosis in a variety of human cancers. Doxycycline exhibited anti-tumor properties in many cancer cells. CD147 antagonist peptide-9 is a polypeptide and can specifically bind to CD147. The effect of these two drugs on gallbladder cancer cells has not been studied. The aim of this study is to investigate the effect of doxycycline and antagonist peptide-9 on gallbladder carcinoma cells and the possible mechanism of inhibition on cancer cell of doxycycline...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29030873/a-feasibility-study-for-a-triple-blind-randomized-controlled-trial-investigating-the-effects-of-oral-isotretinoin-on-mood-and-quality-of-life-in-patients-with-acne-vulgaris
#17
S Rea, S Tucker, V Frittelli, R Gunnarsson
Isotretinoin is used in the treatment of severe acne vulgaris (AV), but has controversially been associated with depression and suicide. Large prospective studies have failed to translate this clinically. We undertook a feasibility study to investigate the parameters of a triple-blind, randomized controlled trial (RCT) assessing the effect of oral isotretinoin on quality of life (QoL) and mood in patients with AV. Patients meeting the inclusion criteria were randomized for 2 weeks to isotretinoin or doxycycline...
October 13, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29030266/plasmid-mediated-doxycycline-resistance-in-a-yersinia-pestis-strain-isolated-from-a-rat
#18
Nicolas Cabanel, Christiane Bouchier, Minoarisoa Rajerison, Elisabeth Carniel
Emergence of antibiotic-resistant Y. pestis strains represents a public health concern. Two antibiotic-resistant Y. pestis strains isolated from Madagascar were previously identified and characterized. Both strains carried conjugative plasmids that conferred resistance to streptomycin or to multiple antibacterial drugs. Here we characterized a novel Y. pestis strain (IP2180H) that exhibited resistance to doxycycline. This strain was isolated from a rat in Antananarivo (Madagascar) in 1998. Resistance was carried by a conjugative plasmid (pIP2180H) homologous to pB71 from Salmonella enterica...
October 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29030100/antimicrobial-susceptibility-profiles-of-oral-treponema-species
#19
Kazuko Okamoto-Shibayama, Jin Sekino, Kouki Yoshikawa, Atsushi Saito, Kazuyuki Ishihara
Treponemes occur in the microflora of the dental plaque. Certain Treponema species that are frequently isolated from chronic periodontitis lesions are involved in its initiation and progression. In addition to mechanical instrumentation, antimicrobial agents are used as an adjunctive treatment modality for periodontitis. Despite its importance for successful antimicrobial treatment, information about susceptibility is limited for Treponema species. The aim of this study was to assess the susceptibility of two Treponema denticola strains, Treponema socranskii, and Treponema vincentii to eleven antimicrobial agents...
October 10, 2017: Anaerobe
https://www.readbyqxmd.com/read/29029059/canonical-wnt-%C3%AE-catenin-signaling-regulates-postnatal-mouse-epididymal-development-but-does-not-affect-epithelial-cell-differentiation
#20
Manish Kumar, Pradeep S Tanwar
The epithelial lining of epididymis establishes an optimal environment in which spermatozoa acquire the ability to fertilize an oocyte. This highly specialized organ develops from a simple embryonic tube known as the Wolffian duct (WD). How the simple columnar epithelium of WD acquires the complex features of the adult epididymal epithelium is currently unclear. During these first few weeks after birth, the epididymal epithelium undergoes significant changes and by five weeks, consists of four different cell types...
October 5, 2017: Endocrinology
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