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https://www.readbyqxmd.com/read/29456382/deflazacort-induced-acneiform-eruptions
#1
Mohammed Shakeel Mohammed Bashir, Mohammad Saleem, Uday Choudhari
A 38-year-old male suffering from a low backache since 3 months was diagnosed as a case of L4-L5 disc prolapse after magnetic resonance imaging examination. He was treated with tolperisone, aceclofenac, and paracetamol in these drugs deflazacort added later. From the 2nd day of an addition of deflazacort in the therapy, sharply marginated, infiltrative, and erythematous skin eruptions with discrete itching sensations were seen. It was diagnosed as deflazacort-induced acneiform eruption and treated with doxycycline for 2 months which led to the disappearance of acneiform eruptions...
October 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29456312/long-term-effect-of-lactobacillus-brevis-cd2-inersan-%C3%A2-and-or-doxycycline-in-aggressive-periodontitis
#2
Mishal Piyush Shah, Sheela Kumar Gujjari, Veerendrakumar Siddhpur Chandrasekhar
Context: The over usage and broad use of antibiotics resulted in the emergence of resistant microorganisms to the drugs which also disturb the indigenous microflora, which include the Lactobacillus in the oral cavity. Hence, it is preferred to avoid the use of antibiotics. Aims: The hypothesis tested in this study was that 14 days of treatment with Lactobacillus brevis CD2 lozenges, L. brevis CD2 with oral doxycycline, or doxycycline alone would have a beneficial effect on periodontal health after 5 months...
July 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29456178/hoxb4-promotes-hemogenic-endothelium-formation-without-perturbing-endothelial-cell-development
#3
Nadine Teichweyde, Lara Kasperidus, Sebastian Carotta, Valerie Kouskoff, Georges Lacaud, Peter A Horn, Stefan Heinrichs, Hannes Klump
Generation of hematopoietic stem cells (HSCs) from pluripotent stem cells, in vitro, holds great promise for regenerative therapies. Primarily, this has been achieved in mouse cells by overexpression of the homeotic selector protein HOXB4. The exact cellular stage at which HOXB4 promotes hematopoietic development, in vitro, is not yet known. However, its identification is a prerequisite to unambiguously identify the molecular circuits controlling hematopoiesis, since the activity of HOX proteins is highly cell and context dependent...
February 15, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29455987/design-and-biological-response-of-doxycycline-loaded-chitosan-microparticles-for-periodontal-disease-treatment
#4
Silvana Gjoseva, Nikola Geskovski, Simona Dimchevska Sazdovska, Riste Popeski-Dimovski, Gjorgji Petruševski, Kristina Mladenovska, Katerina Goracinova
The aim of this study was to develop chitosan (CS) microparticulated mucoadhesive drug delivery system (DDS) with improved therapeutic performance and biological responce. Ionotropic gelation/spray drying process was used for preparation of doxycycline hyclate (DOXY) loaded low and medium molecular weight (LMw and MMw) CS/sodium tripolyphosphate microparticles (CS/TPP MPs), further coated with ethyl cellulose (EC) using coacervation/solvent displacement technique. The relevant physico-chemical and biopharmaceutical properties were optimized using experimental design approach...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29452667/overview-on-the-management-of-non-gastric-malt-lymphomas
#5
REVIEW
Irene Defrancesco, Luca Arcaini
Extranodal marginal zone B-cell lymphomas (EMZLs) of the mucosa-associated lymphoid tissue (MALT) are indolent lymphomas which can present at any extranodal site. The most frequent localizations (other than stomach) are ocular adnexa, salivary gland, skin, lung and thyroid. Chronic inflammation and antigenic stimulation are a potential risk for the development of MALT lymphomas. While Helicobacter Pylori (HP) is known to be associated with gastric MALT lymphoma and antibiotic therapy is effective in the setting of HP-positive, other microorganisms (such as Chlamydophila Psittaci, Campylobacter Jejiuni, Borrelia Burgdoferi) have been implicated in the pathogenesis of non-gastric MALT lymphomas...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29446822/pelvic-actinomycosis-fistulised-to-the-skin-treated-with-doxycycline
#6
Talel Badri, Nawal Jaada, Aschraf Debbiche, Inçaf Mokhtar
No abstract text is available yet for this article.
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29446321/pulmonary-il-1%C3%AE-expression-in-early-life-causes-permanent-changes-in-lung-structure-and-function-in-adulthood
#7
Anna Hogmalm, Maija Bry, Kristina Bry
Chorioamnionitis, mechanical ventilation, oxygen therapy, and postnatal infection promote inflammation in the newborn lung. The long-term consequences of pulmonary inflammation during infancy have not been well characterized. The aim of this study was to examine the impact of inflammation during the late saccular to alveolar stages of lung development on lung structure and function in adulthood. To induce IL-1β expression in the pulmonary epithelium of mice with a tetracycline-inducible human IL-1β transgene, doxycycline was administered via intraperitoneal injections to bitransgenic pups and their littermate controls on postnatal days (PN) 0, 0...
February 15, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29444372/primary-cutaneous-small-medium-sized-pleomorphic-t-cell-lymphoproliferative-disorder-shows-a-common-vascular-pattern-at-dermoscopy
#8
Alessandro Pileri, Claudio Agostinelli, Elena Sabattini, Michela Tabanelli, Valeria Gaspari, Miriam Leuzzi, Annalisa Patrizi, Francesco Savoia
Primary cutaneous small/medium-sized pleomorphic T-cell lymphoproliferative disorder (PCSM-TCLPD) is a rare and indolent primary cutaneous T-cell lymphoma variant [1], usually presenting as a solitary nodule or plaque in the head and neck [2] or rarely as multiple lesions in anatomic areas apart from head and neck [2]. Histology reveals the presence of a dense dermal infiltrate of CD4+, CD8-, small/medium pleomorphic cells [2] intermingled with reactive cells. Surgical or radiotherapic approach are the preferred option, while oral doxycycline has been suggested in cases with multiple lesions [2-3]...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29442898/development-of-egg-shell-derived-carbonated-apatite-nanocarrier-system-for-drug-delivery
#9
R Jayasree, K Madhumathi, Deepti Rana, Murugan Ramalingam, Rakesh P Nankar, Mukesh Doble, T S Sampath Kumar
Carbonated apatite has a chemical composition quite similar to biological apatite found in native bone. The incorporation of carbonate (CO2-3) ions groups into the apatitic crystal structure can tailor its crystallinity, solubility and biological activity that benefit the bone repair and regeneration. In this study, we report a simple and elegant method of synthesizing carbonated calcium deficient hydroxyapatite (ECCDHA) nanoparticles from egg shell wastes and its efficacy has been compared with synthetic calcium deficient hydroxyapatite (SCDHA) nanoparticles...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442713/antibacterial-activities-of-bacteriagenic-silver-nanoparticles-against-nosocomial-acinetobacter-baumannii
#10
Richa Singh, Jeet Vora, Shradhda B Nadhe, Sweety A Wadhwani, Utkarsha U Shedbalkar, Balu A Chopade
Acinetobacter baumannii has emerged as one of the major nosocomial pathogens implicated in variety of severe infections and mortality. It is rapidly developing multi-drug resistance and also possesses surface colonization ability, which make it most difficult to treat through traditional antibiotics. This is an extensive study to describe the antibacterial activity of bacteriagenic silver nanoparticles (AgNPs) against A. baumannii AIIMS 7 in planktonic and biofilm mode. Minimum inhibitory concentration of antibiotics were in the range of 1 to 4096 μg/ml whereas AgNPs inhibited planktonic bacteria at concentration of 16 μg/ml...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29441558/safety-gains-don-t-translate-into-reduced-costs-or-increased-qalys-for-doxycycline-compared-with-prednisolone-for-patients-with-bullous-pemphigoid
#11
T Sach
No abstract text is available yet for this article.
February 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29438386/doxycycline-inhibits-experimental-cerebral-malaria-by-reducing-inflammatory-immune-reactions-and-tissue-degrading-mediators
#12
Kim E Schmidt, Janina M Kuepper, Beatrix Schumak, Judith Alferink, Andrea Hofmann, Shanshan W Howland, Laurent Rénia, Andreas Limmer, Sabine Specht, Achim Hoerauf
Malaria ranks among the most important infectious diseases worldwide and affects mostly people living in tropical countries. Mechanisms involved in disease progression are still not fully understood and specific treatments that might interfere with cerebral malaria (CM) are limited. Here we show that administration of doxycycline (DOX) prevented experimental CM (ECM) in Plasmodium berghei ANKA (PbA)-infected C57BL/6 wildtype (WT) mice in an IL-10-independent manner. DOX-treated mice showed an intact blood-brain barrier (BBB) and attenuated brain inflammation...
2018: PloS One
https://www.readbyqxmd.com/read/29435159/undermining-ribosomal-rna-transcription-in-both-the-nucleolus-and-mitochondrion-an-offbeat-approach-to-target-myc-driven-cancer
#13
Stefano Rossetti, Andrzej J Wierzbicki, Nicoletta Sacchi
The MYC transcription factor coordinates, via different RNA polymerases, the transcription of both ribosomal RNA (rRNA) and protein genes necessary for nucleolar as well as mitochondrial ribogenesis. In this study we tested if MYC-coordination of rRNA transcription in the nucleolus and in the mitochondrion drives (cancer) cell proliferation. Here we show that the anti-proliferative effect of CX-5461, a Pol I inhibitor of rRNA transcription, in ovarian (cancer) cell contexts characterized by MYC overexpression is enhanced either by 2'-C-Methyl Adenosine (2'-C-MeA), a ribonucleoside that inhibits POLRMT mitochondrial rRNA (mt-rRNA) transcription and doxycycline, a tetracycline known to affect mitochondrial translation...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29432443/short-term-doxycycline-treatment-induces-sustained-improvement-in-myocardial-infarction-border-zone-contractility
#14
Kimberly Spaulding, Kiyoaki Takaba, Alexander Collins, Farshid Faraji, Guanying Wang, Esteban Aguayo, Liang Ge, David Saloner, Arthur W Wallace, Anthony J Baker, David H Lovett, Mark B Ratcliffe
Decreased contractility in the non-ischemic border zone surrounding a MI is in part due to degradation of cardiomyocyte sarcomeric components by intracellular matrix metalloproteinase-2 (MMP-2). We recently reported that MMP-2 levels were increased in the border zone after a MI and that treatment with doxycycline for two weeks after MI was associated with normalization of MMP-2 levels and improvement in ex-vivo contractile protein developed force in the myocardial border zone. The purpose of the current study was to determine if there is a sustained effect of short term treatment with doxycycline (Dox) on border zone function in a large animal model of antero-apical myocardial infarction (MI)...
2018: PloS One
https://www.readbyqxmd.com/read/29428849/generation-of-a-human-embryonic-stem-cell-line-nerce003-a-1-with-lentivirus-vector-mediated-inducible-ctnnb1-overexpression
#15
Yang Wang, Juan Yu, Lvjun Liu, Wen Li, Xingxiang Duan, Yingying Peng, Sicong Zeng, Qi Ouyang, Guangxiu Lu, Ge Lin, Yi Sun
The human embryonic stem cell (hESC) line NERCe003-A-1 was generated by introducing lentiviral-vector-mediated tetracycline-inducible β-catenin expression into a normal hESC line, NERCe003-A. The resulting cell line can overexpress the β-catenin protein, encoded by the CTNNB1 gene, after exposure to doxycycline (Dox). CTNNB1 gene expression was confirmed by quantitative PCR (qPCR) and immunofluorescence assays. Further characterization confirmed that the NERCe003-A-1 cell line expresses typical pluripotency markers and has the ability to form the three germ layers both in vitro and in vivo...
February 3, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29426804/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biologic-therapies-an-infectious-diseases-perspective-cell-surface-receptors-and-associated-signaling-pathways
#16
REVIEW
J Aguilar-Company, M Fernández-Ruiz, R García-Campelo, A C Garrido-Castro, I Ruiz-Camps
BACKGROUND: The present review is part of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group for Infections in Compromised Hosts (ESGICH) consensus document on the safety of targeted and biologic therapies. AIMS: To review, from an infectious diseases perspective, the safety profile of therapies targeting cell surface receptors and associated signaling pathways among cancer patients and to suggest preventive recommendations...
February 6, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29425796/doxycycline-prevents-and-reverses-schizophrenic-like-behaviors-induced-by-ketamine-in-mice-via-modulation-of-oxidative-nitrergic-and-cholinergic-pathways
#17
Benneth Ben-Azu, Itivere Adrian Omogbiya, Adegbuyi Oladele Aderibigbe, Solomon Umukoro, Abayomi Mayowa Ajayi, Ezekiel O Iwalewa
The involvement of oxidative/nitrosative stress, cholinergic and inflammatory pathways have been reported to contribute to the pathophysiology of schizophrenia, a debilitating neuropsychiatric disorder. Our previous studies have shown that doxycycline (DOX), a notable member of tetracyclines with proven antioxidant and anti-inflammatory properties, attenuated psychotic-like behaviors induced by apomophine and ketamine (KET) in mice. This present study was designed to further evaluate in detail the ability of DOX and its combination with risperidone (RIS) to prevent and reverse KET-induced schizophrenic-like behaviors and the role of oxidative/nitrosative and cholinergic pathways in mice...
February 6, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29416805/pro-apoptotic-effect-of-doxycycline-and-hydroxychloroquine-on-b-cell-lymphoma-induced-by-c-burnetii
#18
Cléa Melenotte, Didier Raoult
No abstract text is available yet for this article.
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414411/establishment-and-characterization-of-a-human-embryonic-stem-cell-line-nerce002-a-3-with-inducible-14-3-3%C3%AE-overexpression
#19
Jingjing He, Xingxiang Duan, Wen Li, Yingying Peng, Juan Yu, Liang Hu, Sicong Zeng, Yang Wang, Guangxiu Lu, Ge Lin, Yi Sun
NERCe002-A-3 cells were generated from the normal human embryonic stem cell line NERCe002-A. NERCe002-A-3 cells overexpressed 14-3-3ζ after exposure to doxycycline. 14-3-3ζ protein have the ability to bind a multitude of functionally diverse signalling proteins. The NERCe002-A-3 cell line is considered a model for functional studies of the 14-3-3ζ protein in hESC self-renewal and cell differentiation. Doxycycline-treated NERCe002-A-3 cells showed a>27-fold increase in relative expression of 14-3-3ζ as compared with un-induced cells...
January 30, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29409745/association-of-non-immediate-drug-hypersensitivity-with-drug-exposure-a-case-control-analysis-of-spontaneous-reports-from-a-tunisian-pharmacovigilance-database
#20
Amel Chaabane, Najeh Ben Fadhel, Zohra Chadli, Haifa Ben Romdhane, Nadia Ben Fredj, Naceur A Boughattas, Karim Aouam
PURPOSE: To assess delayed-type cutaneous reactions (DTCRs) related to drugs, using a case-control approach to qualify drug risks. METHODS: The study used the Tunisian pharmacovigilance database of Monastir. The association between drugs and DTCRs was assessed using a case/non-case method. Drugs were grouped according to the ATC Classification System. Patients were defined as "cases" if they have developed DTCRs regardless of the causality assessment. All other reports were "non-cases"...
February 3, 2018: European Journal of Internal Medicine
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