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https://www.readbyqxmd.com/read/29228132/vivax-malaria-chemoprophylaxis-the-role-of-atovaquone-proguanil-compared-to-other-options
#1
Meltzer Eyal, Galia Rahav, Schwartz Eli
Background: Atovaquone-Proguanil is considered causal prophylaxis (inhibition of liver-stage schizonts) for Plasmodium falciparum, however, its causal prophylactic efficacy for P. vivax is not known. Travelers returning to non-endemic areas, provide a unique opportunity to study P. vivax prophylaxis. Methods: A retrospective observational study. For 11 years Israeli rafters who had traveled to the Omo River in Ethiopia, a highly malaria endemic area, were followed for at least one year after their return...
December 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29225599/promoter-specificity-and-efficacy-in-conditional-and-inducible-transgenic-targeting-of-lung-macrophages
#2
Alexandra L McCubbrey, Kristen C Allison, Alisa B Lee-Sherick, Claudia V Jakubzick, William J Janssen
Conditional and inducible Cre-loxP systems are used to target gene deletion to specific cell lineages and tissues through promoter-restricted expression of the bacterial DNA recombinase, Cre. Although Cre-loxP systems are widely used to target gene deletion in lung macrophages, limited data are published on the specificity and efficiency of "macrophage targeting" Cre lines. Using R26-stopfl/fl-TdTomato and tetOn-GFP reporter lines, we assessed the specificity and efficiency of four commercially available Cre driver lines that are often considered "macrophage specific...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29223117/removal-of-veterinary-antibiotics-from-wastewater-by-electrocoagulation
#3
Wojciech Baran, Ewa Adamek, Marcin Jajko, Andrzej Sobczak
The aim of this study was to assess the effectiveness of veterinary antibiotic removal from wastewater using an electrocoagulation method. The removal efficiency of ampicillin, doxycycline, sulfathiazole and tylosin; the antibiotic degradation degree after electrolysis; and the toxicity and qualitative composition of antibiotic solutions after electrocoagulation were determined in the experiments. HPLC-QTOF was used for quantitative and qualitative determination. The eco-toxicity was assessed using the MARA® assay...
November 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29220404/pymt-maclow-a-novel-inducible-murine-model-for-determining-the-role-of-cd68-positive-cells-in-breast-tumor-development
#4
Robin M H Rumney, Seth B Coffelt, Terence A Neale, Sandeep Dhayade, Gillian M Tozer, Gaynor Miller
CD68+ tumor-associated macrophages (TAMs) are pro-tumorigenic, pro-angiogenic and are associated with decreased survival rates in patients with cancer, including breast cancer. Non-specific models of macrophage ablation reduce the number of TAMs and limit the development of mammary tumors. However, the lack of specificity and side effects associated with these models compromise their reliability. We hypothesized that specific and controlled macrophage depletion would provide precise data on the effects of reducing TAM numbers on tumor development...
2017: PloS One
https://www.readbyqxmd.com/read/29216689/-doxycycline-as-an-adjuvant-in-postsurgical-recovery-of-rotator-cuff-injuries-one-year-follow-up
#5
J I Díaz-Sanabria, C Trueba-Vasavilbaso, F Gil-Orbezo, C Trueba-Davalillo, M Acuña-Tovar
BACKGROUND: The severity and progression of rotator cuff tears have forced research on new treatment pathways such as metalloprotease inhibition, which has shown a reduction in healing time and improvement in the structure of collagen fibers. OBJECTIVE: To evaluate the use of doxycycline as a healing enhancer in rotator cuff tears after surgical treatment. MATERIAL AND METHODS: 20 patients were included; they were divided into two groups, 10 with the use of doxycycline and 10 without it after arthroscopic repair with one-year follow-up...
July 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29216470/occurrence-and-risk-assessment-of-antibiotics-in-water-and-lettuce-in-ghana
#6
David Azanu, Bjarne Styrishave, Godfred Darko, Johan Juhl Weisser, Robert Clement Abaidoo
Hospital wastewater and effluents from waste stabilization ponds in Kumasi, Ghana, are directly discharged as low quality water into nearby streams which are eventually used to irrigate vegetables. The presence of 12 commonly used antibiotics in Ghana (metronidazole, ciprofloxacin, erythromycin, trimethoprim, ampicillin, cefuroxime, sulfamethoxazole, amoxicillin, tetracycline, oxytetracycline, chlortetracycline and doxycycline) were investigated in water and lettuce samples collected in three different areas in Kumasi, Ghana...
December 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29212806/syndecan-1-promotes-wnt-%C3%AE-catenin-signaling-in-multiple-myeloma-by-presenting-wnts-and-r-spondins
#7
Zemin Ren, Harmen van Andel, Wim de Lau, Robin B Hartholt, Madelon M Maurice, Hans Clevers, Marie José Kersten, Marcel Spaargaren, Steven T Pals
Multiple myeloma (MM) is characterized by the expansion of malignant plasma cells in the bone marrow (BM). Most MMs display aberrant Wnt/β-catenin signaling, which drives proliferation; however, they lack oncogenic Wnt-pathway mutations, suggesting activation by autocrine Wnt ligands and/or paracrine Wnts from the BM microenvironment. Expression of the heparan sulfate proteoglycan (HSPG) syndecan-1 is a hallmark of MM. Syndecan-1 is a critical player in the complex reciprocal interaction between MM cells and their BM niche, mediating growth factor/cytokine binding and signaling by its heparan sulfate (HS) chains...
December 6, 2017: Blood
https://www.readbyqxmd.com/read/29210169/electrospun-nanofibers-comprising-of-silk-fibroin-gelatin-for-drug-delivery-applications-thyme-essential-oil-and-doxycycline-monohydrate-release-study
#8
Masoud Dadras Chomachayi, Atefeh Solouk, Somaye Akbari, Davoud Sadeghi, Fereshteh Mirahmadi, Hamid Mirzadeh
In this study, a nanofibrous electrospun substrate based on the silk fibroin (SF) and gelatin (GT) polymers were prepared and evaluated. The SF/GT blended solutions were prepared with various ratios of GT in formic acid and electrospun to obtain bead-free fibers. Results showed that addition of GT to SF increased nanofiber's diameter, bulk hydrophilicity, surface wettability, mass loss percentage, but decreased Young's modulus, tensile strength, and porosity of the SF/GT mats. According to the obtained results, the mat containing 10% of GT was selected as the optimized mat for further studies and loaded with thyme essential oil (TEO) and doxycycline monohydrate (DCMH) as the antibacterial agents...
December 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29208285/hybrid-nanofibers-based-on-poly-caprolactone-gelatin-hydroxyapatite-nanoparticles-loaded-doxycycline-effective-anti-tumoral-and-antibacterial-activity
#9
Ricardo Ramírez-Agudelo, Karina Scheuermann, Alfonso Gala-García, Ana Paula F Monteiro, Ana Delia Pinzón-García, Maria E Cortés, Rubén D Sinisterra
Cancer is one of the leading causes of morbidity and mortality Worldwide, 19.3 million new cancer cases are expected to be identified in 2025. Among the therapeutic arsenal to cancer control one could find the Doxycycline and the nano hydroxyapatite. The Doxycycline (Dox) not only shown antibiotic effect but also exhibits a wide range of pleiotropic therapeutic properties as the control of the invasive and metastatic cancer cells characteristics. The purpose of the present study was to evaluate both cytotoxicity in vitro and antibacterial activity of electrospun Dox-loaded hybrid nanofibrous scaffolds composed by hydroxyapatite nanoparticles (nHA), poly-ε-caprolactone (PCL) and gelatin (Gel) polymers...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29207004/phenotypic-antimicrobial-susceptibility-testing-of-chlamydia-trachomatis-isolates-from-patients-with-persistent-or-successfully-treated-infections
#10
Rachel Pitt, Sarah Alexander, Catherine Ison, Patrick Horner, Emma Hathorn, Penny Goold, Neil Woodford, Michelle J Cole
Objectives: Antimicrobial susceptibility data for Chlamydia trachomatis are lacking. Methodologies for susceptibility testing in C. trachomatis are not well-defined, standardized or performed routinely owing to its intracellular growth requirements. We sought to develop an assay for the in vitro susceptibility testing of C. trachomatis isolates from two patient cohorts with different clinical outcomes. Methods: Twenty-four clinical isolates (11 from persistently infected and 13 from successfully treated patients) were overlaid with media containing two-fold serial dilutions of azithromycin or doxycycline...
November 30, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29205851/regulated-cell-death-of-lymphoma-cells-after-graded-mitochondrial-damage-is-differentially-affected-by-drugs-targeting-cell-stress-responses
#11
Tomás Lombardo, Martín Gil Folgar, Luciana Salaverry, Estela Rey-Roldán, Elida M Alvarez, María C Carreras, Laura Kornblihtt, Guillermo A Blanco
Collapse of the mitochondrial membrane potential (MMP) is often considered the initiation of regulated cell death (RCD). Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) is an uncoupler of the electron transport chain (ETC) that facilitates the translocation of protons into the mitochondrial matrix leading to the collapse of the MMP. Several cell stress responses such as mitophagy, mitochondrial biogenesis and the ubiquitin proteasome system, may differentially contribute to restrain the initiation of RCD depending on the extent of mitochondrial damage...
December 4, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29200167/a-severe-case-of-murine-typhus-presenting-with-anemia-and-severe-thrombocytopenia
#12
Jade Wulff, Judith Margolin, Nana E Coleman, Gail Demmler-Harrison, Fong Lam, Mona D Shah
We discuss a child with severe thrombocytopenia and mild anemia admitted to the Hematology service who quickly deteriorated to a life-threatening state. However, once rickettsial disease was considered in the differential diagnosis and empiric doxycycline begun, she quickly and fully recovered. A diagnostic panel, including Rickettsia typhi serology, confirmed the diagnosis of murine typhus but this occurred weeks after she had recovered. Given the potential severity of rickettsial diseases and the ease of modern travel across geographic borders, hematology-oncology providers everywhere must consider rickettsial diseases in their differential diagnosis of critically ill children and begin empiric therapy with doxycycline promptly...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29198181/2017-european-guideline-for-the-management-of-pelvic-inflammatory-disease
#13
Jonathan Ross, Secondo Guaschino, Marco Cusini, Jorgen Jensen
The European guideline for the management of pelvic inflammatory disease includes evidence-based advice on the investigation and treatment of pelvic inflammatory disease (PID). It has been updated to acknowledge the role of Mycoplasma genitalium as an important cause of PID with testing now recommended for women presenting with possible PID and for the male partners of women with confirmed M. genitalium infection. Recent evidence suggests that serious adverse events are uncommon when using moxifloxacin and its use is now recommended as a first-line therapy, especially in those women with M...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29197122/efficacy-of-minocycline-in-naturally-occurring-nonacute-ehrlichia-canis-infection-in-dogs
#14
S Jenkins, J K Ketzis, J Dundas, D Scorpio
BACKGROUND: Minocycline has been used in the treatment of Ehrlichia canis infection in dogs as an alternative to doxycycline, the recommended treatment. However, efficacy of this alternative therapy is unknown. OBJECTIVE: To assess the efficacy of minocycline in the treatment of natural occurring E. canis infection in dogs. ANIMALS: Ten privately owned dogs of mixed breed positive for E. canis by blood PCR. METHODS: Prospective, randomized clinical study...
December 2, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29193331/host-modulation-therapy-with-anti-inflammatory-agents
#15
REVIEW
Philip M Preshaw
Host modulation therapy refers to a treatment concept in which drug therapies are used as an adjunct to conventional periodontal treatment to ameliorate destructive aspects of the host inflammatory response. This strategy is not new in the treatment of periodontitis. Previously, nonsteroidal anti-inflammatory drugs have been investigated in this regard, with evidence of reductions in alveolar bone resorption when these drugs are used for prolonged periods of time. However, the risk of significant unwanted effects precludes the use of both nonselective nonsteroidal anti-inflammatory drugs and the selective cyclooxygenase-2 inhibitors as adjunctive treatments for periodontitis...
November 29, 2017: Periodontology 2000
https://www.readbyqxmd.com/read/29192991/doxycycline-and-the-treatment-for-bullous-pemphigoid-what-outcomes-are-most-important-to-our-patients
#16
EDITORIAL
A R Cardones, R P Hall
No abstract text is available yet for this article.
November 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29191612/in-vivo-activity-of-fluconazole-tetracycline-combinations-in-galleria-mellonella-with-resistant-candida-albicans-infection
#17
Wenrui Gu, Qiong Yu, Cuixiang Yu, Shujuan Sun
OBJECTIVE: The treatment of azoles-resistant Candida albicans infections continues to pose significant challenges. With limited options of licensed agents, the drug's combination turns out to be a practical way. In our previous studies, minocycline/fluconazole (MINO/FLC) and doxycycline/fluconazole (DOXY/FLC) combinations shown synergistic effect in vitro. It is necessary to explore appropriate dosage, potential toxicity and in vivo efficacy. METHODS: The Galleria mellonella infection model was employed to study the in vivo efficacy of MINO/FLC and DOXY/FLC by survival analysis, quantification of C...
November 27, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29188069/simultaneous-isolation-of-chryseobacterium-gleum-from-bloodstream-and-respiratory-tract-first-case-report-from-india
#18
Vidhi Jain, Nayani Amrin Fatema Afzal Hussain, Tasneem Siddiqui, Chinmoy Sahu, Malay Ghar, Kashi Nath Prasad
Introduction. Species of the genus Chryseobacterium are emerging healthcare-associated pathogens, often colonizing the hospital environment. There are no clear guidelines available for antimicrobial susceptibility of this organism. In this report we present the first case, to our knowledge, of simultaneous central-line-associated bloodstream infection (CLABSI) and ventilator-associated pneumonia (VAP) due to Chryseobacterium gleum from India. Case presentation. A 62 years old man with a history of a road traffic accident 1 month previously was referred to our center for further management...
October 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29187243/doxycycline-induces-dysbiosis-in-female-c57bl-6ncrl-mice
#19
Felicia D Duke Boynton, Aaron C Ericsson, Mayu Uchihashi, Misha L Dunbar, J Erby Wilkinson
OBJECTIVE: This study aims to demonstrate the effect of oral doxycycline on fecal microbiota of mice. Doxycycline is a common effector for control of gene expression using the tet-inducible system in transgenic mice. The effect of oral doxycycline on murine gut microbiota has not been reported. We evaluated the effect of doxycycline treatment by sequencing the V4 hypervariable region of the 16S rRNA gene from fecal samples collected during a 4 week course of treatment at a dose of 2 mg/ml in the drinking water...
November 29, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29187146/determination-of-antimicrobial-susceptibility-patterns-in-staphylococcus-aureus-strains-recovered-from-patients-at-two-main-health-facilities-in-kabul-afghanistan
#20
Haji Mohammad Naimi, Hamidullah Rasekh, Ahmad Zia Noori, Mohammad Aman Bahaduri
BACKGROUND: Staphylococcus aureus (S. aureus) is a major pathogen implicated in skin and soft tissue infections, abscess in deep organs, toxin mediated diseases, respiratory tract infections, urinary tract infections, post-surgical wound infections, meningitis and many other diseases. Irresponsible and over use of antibiotics has led to an increased presence of multidrug resistant organisms and especially methicillin resistant Staphylococcus aureus (MRSA) as a major public health concern in Afghanistan...
November 29, 2017: BMC Infectious Diseases
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