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https://www.readbyqxmd.com/read/28323552/helicobacter-pylori-eradication-in-the-swedish-population
#1
Eva Doorakkers, Jesper Lagergren, Vijaya Krishna Gajulapuri, Steven Callens, Lars Engstrand, Nele Brusselaers
OBJECTIVES: Helicobacter pylori is associated with peptic ulcers and gastric cancer and its eradication aims to prevent these conditions. The recommended eradication regimen is triple therapy, consisting of a proton-pump inhibitor in combination with clarithromycin and amoxicillin or metronidazole for 7 days. Yet, other antibiotic regimens are sometimes prescribed. We aimed to assess the use of eradication therapy for H. pylori in the Swedish population during the last decade. MATERIALS AND METHODS: This population-based study used data from the Swedish Prescribed Drug Register...
March 21, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28318694/facile-synthesis-of-cu-ii-impregnated-biochar-with-enhanced-adsorption-activity-for-the-removal-of-doxycycline-hydrochloride-from-water
#2
Su Liu, Wei-Hua Xu, Yun-Guo Liu, Xiao-Fei Tan, Guang-Ming Zeng, Xin Li, Jie Liang, Zan Zhou, Zhi-Li Yan, Xiao-Xi Cai
In this study, the effect factors and mechanisms of doxycycline hydrochloride (DOX) adsorption on copper nitrate modified biochar (Cu-BC) was investigated. Cu-BC absorbent was synthesized through calcination of peanut shells biomass at 450°C and then impregnation with copper nitrate. The Cu-BC has exhibited excellent sorption efficiency about 93.22% of doxycycline hydrochloride from aqueous solution, which was double higher than that of the unmodified biochar. The experimental results suggest that the adsorption efficiency of DOX on the Cu-BC is dominated by the strong complexation, electrostatic interactions between DOX molecules and the Cu-BC samples...
March 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28317803/an-unusual-antibiotic-susceptibility-pattern-in-a-mycobacterium-cosmeticum-strain-isolated-from-the-chesapeake-bay
#3
Vajini Atukorale, Nicholas Boire, Kim Dionne, Stefan Riedel, Nicole Parrish
OBJECTIVE/BACKGROUND: Mycobacterium cosmeticum, first described in 2004, was recovered from a patient undergoing a cosmetic procedure. Subsequently, this species was associated with an outbreak in a nail salon. In all cases, the isolates were susceptible to all antibiotics tested. Recently, however, we recovered a strain of M. cosmeticum from the Chesapeake Bay, resistant to 11 of 14 antimicrobials. The objective of this work was to present our findings on the resistance and susceptibility of this isolate to various antibiotics...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28316371/znf395-is-an-activator-of-a-subset-of-ifn-stimulated-genes
#4
Linda Schroeder, Christine Herwartz, Darko Jordanovski, Gertrud Steger
Activation of the interferon (IFN) pathway in response to infection with pathogens results in the induction of IFN-stimulated genes (ISGs) including proinflammatory cytokines, which mount the proper antiviral immune response. However, aberrant expression of these genes is pathogenic to the host. In addition to IFN-induced transcription factors non-IFN-regulated factors contribute to the transcriptional control of ISGs. Here, we show by genome wide expression analysis, siRNA-mediated suppression and Doxycycline-induced overexpression that the cellular transcription factor ZNF395 activates a subset of ISGs including the chemokines CXCL10 and CXCL11 in keratinocytes...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28316061/loss-of-dystrophin-is-associated-with-increased-myocardial-stiffness-in-a-model-of-left-ventricular-hypertrophy
#5
Martín Donato, Bruno Buchholz, Celina Morales, Laura Valdez, Tamara Zaobornyj, Sergio Baratta, Diamela T Paez, Mirian Matoso, Guillermo Vaccarino, Demian Chejtman, Oscar Agüero, Juan Telayna, José Navia, Alejandro Hita, Alberto Boveris, Ricardo J Gelpi
Transition from compensated to decompensated left ventricular hypertrophy (LVH) is accompanied by functional and structural changes. Here, the aim was to evaluate dystrophin expression in murine models and human subjects with LVH by transverse aortic constriction (TAC) and aortic stenosis (AS), respectively. We determined whether doxycycline (Doxy) prevented dystrophin expression and myocardial stiffness in mice. Additionally, ventricular function recovery was evaluated in patients 1 year after surgery. Mice were subjected to TAC and monitored for 3 weeks...
March 18, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28314765/no-back-seat-for-a-progression-event-k-ras-as-a-therapeutic-target-in-crc
#6
REVIEW
Emily J Poulin, Kevin M Haigis
KRAS is the most frequently mutated oncogene in human cancer and plays a central, although poorly understood, role in colorectal cancer (CRC) progression. In this issue of Genes & Development, Boutin and colleagues (pp. 370-382) present a new mouse model of CRC in which the expression of oncogenic K-RAS is regulated by doxycycline. Using this model, they demonstrate that continued expression of oncogenic K-RAS is required for the survival of primary and metastatic colon cancers and that oncogenic K-RAS activates TGF-β signaling to promote tumor invasion and metastasis...
February 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28314470/infectious-encephalitis-management-without-etiological-diagnosis-48hours-after-onset
#7
REVIEW
P Fillatre, Y Crabol, P Morand, L Piroth, J Honnorat, J P Stahl, M Lecuit
INTRODUCTION: The etiological diagnosis of infectious encephalitis is often not established 48hours after onset. We aimed to review existing literature data before providing management guidelines. METHOD: We performed a literature search on PubMed using filters such as "since 01/01/2000", "human", "adults", "English or French", and "clinical trial/review/guidelines". We also used the Mesh search terms "encephalitis/therapy" and "encephalitis/diagnosis". RESULTS: With Mesh search terms "encephalitis/therapy" and "encephalitis/diagnosis", we retrieved 223 and 258 articles, respectively...
March 14, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28303833/antimicrobial-susceptibility-of-leptospira-spp-isolated-from-environmental-human-and-animal-sources-in-malaysia
#8
Douadi Benacer, Siti Nursheena Mohd Zain, Peck Toung Ooi, Kwai Lin Thong
Leptospirosis is a zoonosis with worldwide distribution caused by pathogenic spirochetes of the genus Leptospira. The aim of this study was to evaluate the susceptibility of isolates obtained from different hosts. A total of 65 Leptospira isolates from humans (n = 1), zoonoses (rat, n = 60; dog, n = 1; swine, n = 1) and environment (n = 2) were tested against six antibiotics. All the isolates were resistant to trimethoprim and sulphamethoxazole and had high MIC toward chloramphenicol (MIC90: 6.25 μg/ml). All except one environment isolate were sensitive to ampicillin, doxycycline and penicillin G...
January 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28303006/short-course-high-dose-rifampicin-achieves-wolbachia-depletion-predictive-of-curative-outcomes-in-preclinical-models-of-lymphatic-filariasis-and-onchocerciasis
#9
Ghaith Aljayyoussi, Hayley E Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metugene, Darren A N Cook, Andrew Steven, Raman Sharma, Ana F Guimaraes, Rachel H Clare, Andrew Cassidy, Kelly L Johnston, Laura Myhill, Laura Hayward, Samuel Wanji, Joseph D Turner, Mark J Taylor, Stephen A Ward
Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial curative activity against the filarial nematodes responsible for LF (Brugia malayi, Wuchereria bancrofti) or onchocerciasis (Onchocerca volvulus) is doxycycline. The target of doxycycline is the essential endosymbiont, Wolbachia. Four to six weeks doxycycline therapy achieves >90% depletion of Wolbachia in worm tissues leading to blockade of embryogenesis, adult sterility and premature death 18-24 months post-treatment...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28302108/confirmation-of-plasmodium-falciparum-in-vitro-resistance-to-monodesethylamodiaquine-and-chloroquine-in-dakar-senegal-in-2015
#10
Silman Diawara, Marylin Madamet, Mame Bou Kounta, Gora Lo, Khalifa Ababacar Wade, Aminata Nakoulima, Raymond Bercion, Rémy Amalvict, Mamadou Wague Gueye, Bécaye Fall, Bakary Diatta, Bruno Pradines
BACKGROUND: In response to increasing resistance to anti-malarial drugs, Senegal adopted artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria in 2006. However, resistance of Plasmodium falciparum parasites to artemisinin derivatives, characterized by delayed parasite clearance after treatment with ACT or artesunate monotherapy, has recently emerged and rapidly spread in Southeast Asia. After 10 years of stability with rates ranging from 5.6 to 11...
March 16, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28300926/rosacea-fulminans-unusual-clinical-presentation-of-rosacea
#11
Jessica Castiel Coutinho, Danielle Cristine Westphal, Laís Cruz Lobato, Antônio Pedro Mendes Schettini, Mônica Santos
Rosacea fulminans or pyoderma faciale is a rare cutaneous disorder that usually affects women usually between the ages of 15-46. The disease is characterized by sudden onset of papules, pustules, cysts, and painful coalescing nodules with red-cyanotic centrofacial erythema. Although its etiology remains unknown, hormonal, immunological, and vascular factors have been reported. Early diagnosis and prompt treatment should minimize unsightly scars. We report a case of a 33-year-old female patient treated with traditional doses of doxycycline, with improvement of the lesions and regression of the condition in two months...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28300903/extensive-bullous-lichen-sclerosus-et-atrophicus
#12
Jelica Vukicevic
Lichen sclerosus et atrophicus is a chronic disease of unknown etiology characterized by atrophic and sclerotic plaques in both genital and extragenital regions. Extensive bullous lichen sclerosus et atrophicus (BLSA) is a severe variant of the disease with no widely accepted treatment. We present a 63-year-old woman with extensive extragenital, ivory-colored, atrophic plaques on her trunk and extremities and disseminated hemorrhagic bullae. The patient was unsuccessfully treated with standard topical corticosteroid therapy, doxycycline and chloroquine...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28300560/doxycycline-protects-human-intestinal-cells-from-hypoxia-reoxygenation-injury-implications-from-an-in-vitro-hypoxia-model
#13
Lars Hummitzsch, Karina Zitta, Rouven Berndt, Matthias Kott, Christin Schildhauer, Kerstin Parczany, Markus Steinfath, Martin Albrecht
Intestinal ischemia/reperfusion (I/R) injury is a grave clinical emergency and associated with high morbidity and mortality rates. Based on the complex underlying mechanisms, a multimodal pharmacological approach seems necessary to prevent intestinal I/R injury. The antibiotic drug doxycycline, which exhibits a wide range of pleiotropic therapeutic properties, might be a promising candidate for also reducing I/R injury in the intestine. To investigate possible protective effects of doxycycline on intestinal I/R injury, human intestinal CaCo-2 cells were exposed to doxycycline at clinically relevant concentrations...
March 12, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28298247/tissue-specific-inhibition-of-urokinase-type-plasminogen-activator-expression-in-the-testes-of-mice-by-inducible-lentiviral-rna-interference-causes-male-infertility
#14
Kai Zhao, Yan Liu, Zhe Xiong, Lian Hu, Cheng-Liang Xiong
Urokinase-type plasminogen activator (uPA) is involved in many physiological processes, including male infertility. To explore the effects of uPA in male reproduction, we constructed an inducible uPA short hairpin RNA (shRNA) system expressed by lentiviral vectors. After proving inhibition of uPA expression in the mouse Sertoli cell line TM4 by 1μgmL-1 doxycycline (Dox), two lentivirus (pLenti4-shRNA and pLenti6/TR) were co-microinjected into mouse testes to produce TetR&shuPA mice model. Though oral gavage by 0...
March 16, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28294314/generation-of-precursor-immature-and-mature-murine-b1-cell-lines-from-c-myc-bcl-xl-overexpressing-pre-bi-cells
#15
Inge Wolf, Corinne Bouquet, Friederike Naumann, Fritz Melchers
Deregulated expression of c-myc and bcl-xL is long known to generate transformed B cells in humans and mice. We overexpressed these genes to induce in vitro and in vivo differentiation of fetal liver-derived mouse pre-BI cells to B1-lineage pre-BII-like, immature and mature B-cell lines and to Ig-secreting cells. In vitro, doxycycline-controlled c-myc/bcl-xL-overexpressing CD19(+) CD93(+) c-kikt(+) IgM(-) pre-BI cells differentiate to and survive as CD19(+) CD93(+) c-kit(-) IgM(+) immature B1 cells. Timed CpG-stimulation of these oncogene-overexpressing pre-B or immature B1 cells generates either CD19(+) CD93(low) c-kit(-) IgM(-) SLC(-) pre-BII-like, or IgM(+) MHCII(+) CD73(+) CD80(+) CD40(+) mature B1-cell lines and IgM-secreting B1 cells in vitro and fixes their state of differentiation...
March 10, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28291967/phototoxicity-of-doxycycline-a-systematic-review-on-clinical-manifestations-frequency-cofactors-and-prevention
#16
Steven Goetze, Christian Hiernickel, Peter Elsner
BACKGROUND: One of the most important dermatologic side effects of doxycycline is photosensitivity. As doxycycline is important for malaria prophylaxis and malaria is mainly spread in countries with high sun radiation, special attention should be paid to this adverse effect. While there are many publications on the phototoxicity of tetracyclines in general, only a few exist focusing on doxycycline. The objective of this systematic review was to summarize all available reports on clinical manifestations, influencing factors like UV dose or dose of medication, and the possibilities of prevention by sun protection...
March 15, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28291943/a-new-combination-of-a-pleuromutilin-derivative-and-doxycycline-for-treatment-of-multidrug-resistant-acinetobacter-baumannii
#17
Shajila Siricilla, Katsuhiko Mitachi, Junshu Yang, Shakiba Eslamimehr, Maddie R Lemieux, Bernd Meibohm, Yinduo Ji, Michio Kurosu
Multidrug-resistant (MDR) Acinetobacter baumannii is one of the most difficult Gram-negative bacteria to treat and eradicate. In a cell-based screening of pleuromutilin derivatives against a drug sensitive A. baumannii strain (ATCC 19606), new molecules (2-4) exhibit bacteriostatic activity with 3.13 μg/mL concentration and 1 shows bactericidal activity with an MBC of 6.25 μg/mL. The pleuromutilin derivative 1 displays strong synergistic effects with doxycycline in a wide range of concentrations. A 35/1 ratio of 1 and doxycycline (1-Dox35/1) kills drug susceptible A...
March 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28291850/efficiency-of-nanotube-surface-treated-dental-implants-loaded-with-doxycycline-on-growth-reduction-of-porphyromonas-gingivalis
#18
Cimara Fortes Ferreira, Jegdish Babu, Azhang Hamlekhan, Sweetu Patel, Tolou Shokuhfar
PURPOSE: The prevalence of peri-implant infection in patients with dental implants has been shown to range from 28% to 56%. A nanotube-modified implant surface can deliver antibiotics locally and suppress periodontal pathogenic bacterial growth. The aim of this study was to evaluate the deliverability of antibiotics via a nanotube-modified implant. MATERIALS AND METHODS: Dental implants with a nanotube surface were fabricated and loaded with doxycycline. Afterward, each dental implant with a nanotube surface was placed into 2-mL tubes, removed from solution, and placed in a fresh solution daily for 28 days...
March 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28291501/lateral-flow-rapid-test-for-accurate-and-early-diagnosis-of-scrub-typhus-a-febrile-illness-of-historically-military-importance-in-the-pacific-rim
#19
Chien-Chung Chao, Zhiwen Zhangm, Giulia Weissenberger, Hua-Wei Chen, Wei-Mei Ching
Scrub typhus (ST) is an infection caused by Orientia tsutsugamushi. Historically, ST was ranked as the second most important arthropod-borne medical problem only behind malaria during World War II and the Vietnam War. The disease occurs mainly in Southeast Asia and has been shown to emerge and reemerge in new areas, implying the increased risk for U.S. military and civilian personnel deployed to these regions. ST can effectively be treated by doxycycline provided the diagnosis is made early, before the development of severe complications...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28287822/efficiency-and-specificity-of-gene-deletion-in-lung-epithelial-doxycycline-inducible-cre-mice
#20
Meenal Sinha, Clifford A Lowell
Transgenic mouse strains, SP-C-rtTA, CCSP-rtTA and TetO-Cre, have been invaluable in spatiotemporally regulating gene deletion in pulmonary epithelium. In this study, we measured the efficiency and specificity of gene deletion achievable in these mice using the Rosa26-eYFP reporter. Triple transgenic mice (tTg or rtTA/TetO-Cre/Rosa-eYFP) were bred and treated with various doxycycline (dox) regimes to induce gene deletion, which was then quantified in various cell populations by flow cytometry. In these crosses, we found that the TetO-Cre transgene must be transmitted through the female parent to avoid germline gene deletion...
March 13, 2017: American Journal of Respiratory Cell and Molecular Biology
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