keyword
MENU ▼
Read by QxMD icon Read
search

Doxycycline

keyword
https://www.readbyqxmd.com/read/28820719/central-nervous-system-infection-associated-with-orientia-tsutsugamushi-in-south-korea
#1
Han Sang Lee, Jun-Sang Sunwoo, Seon-Jae Ahn, Jangsup Moon, Jung-Ah Lim, Jin-Sun Jun, Woo-Jin Lee, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Il Park, Ki-Young Jung, Sang Kun Lee, Kon Chu
Orientia tsutsugamushi is a major cause of vector-borne infection in Asia. Prompt recognition and appropriate treatment are crucial because of its potentially fatal complications and lack of response to beta-lactam antibiotics. The present study retrospectively evaluated the clinical characteristics and laboratory findings of 16 patients with scrub typhus-related central nervous system (CNS) infections. Single titers ≥ 1:40 of total serum antibodies against O. tsutsugamushi detected by an indirect immunofluorescent assay were considered as positive results...
July 31, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820712/scrub-typhus-as-an-etiology-of-acute-febrile-illness-in-gorakhpur-uttar-pradesh-india-2016
#2
Jeromie Wesley Vivian Thangraj, Mahima Mittal, Valsan Philip Verghese, C P Girish Kumar, Winsley Rose, R Sabarinathan, Ashok Kumar Pandey, Nivedita Gupta, Manoj Murhekar
Seasonal outbreaks of acute encephalitis syndrome (AES) with high mortality occur every year in Gorakhpur region of Uttar Pradesh, India. Earlier studies indicated the role of scrub typhus as the important etiology of AES in the region. AES cases were hospitalized late in the course of their illness. We established surveillance for acute febrile illness (AFI) (fever ≥ 4 days duration) in peripheral health facilities in Gorakhpur district to understand the relative contribution of scrub typhus. Of the 224 patients enrolled during the 3-month period corresponding to the peak of AES cases in the region, about one-fifth had immunoglobulin M (IgM) antibodies against Orientia tsutsugamushi...
August 14, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28819912/a-case-of-q-fever-with-erythema-nodosum
#3
E Meriglier, L Asquier, F Roblot, P Roblot, C Landron
BACKGROUND: Acute Q fever is asymptomatic in 60% of the patients, while the reminder may present with fever, pneumoniae, and hepatitis. Skin manifestations are uncommon including transient punctiform rashes, purpuric, or maculopapular eruptions. Erythema nodosum have seldom been reported. CASE PRESENTATION: A 37-year-old female presented with fever for 1 month and skin lesions consists of erythematous painful nodule of the legs. Serological testing for Coxiella burnetii was positive...
August 17, 2017: Infection
https://www.readbyqxmd.com/read/28819873/similarities-and-differences-between-doxycycline-and-minocycline-clinical-and-antimicrobial-stewardship-considerations
#4
REVIEW
B A Cunha, J Baron, C B Cunha
Doxycycline and, to a lesser extent, minocycline, have been used for decades to treat various serious systemic infections, but many physicians remain unfamiliar with their spectrum, interpretation of susceptibility results, pharmacokinetic/pharmacodynamic (PK/PD) properties, optimal dosing regimens, and their activity against MRSA, VRE, and multidrug-resistant (MDR) Gram-negative bacilli, e.g., Acinetobacter sp. This article reviews the optimal use of doxycycline and minocycline to treat a variety of infections and when minocycline is preferred instead of doxycycline...
August 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28814666/rapamycin-reversal-of-vegf-c-driven-lymphatic-anomalies-in-the-respiratory-tract
#5
Peter Baluk, Li-Chin Yao, Julio C Flores, Dongwon Choi, Young-Kwon Hong, Donald M McDonald
Lymphatic malformations are serious but poorly understood conditions that present therapeutic challenges. The goal of this study was to compare strategies for inducing regression of abnormal lymphatics and explore underlying mechanisms. CCSP-rtTA/tetO-VEGF-C mice, in which doxycycline regulates VEGF-C expression in the airway epithelium, were used as a model of pulmonary lymphangiectasia. After doxycycline was stopped, VEGF-C expression returned to normal, but lymphangiectasia persisted for at least 9 months...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28814589/ureaplasma-parvum-causing-life-threatening-disease-in-a-susceptible-patient
#6
Alexander Korytny, Roni Nasser, Yuval Geffen, Tom Friedman, Mical Paul, Nesrin Ghanem-Zoubi
A 56-year-old man with lymphoma developed orchitis followed by septic arthritis of his right glenohumeral joint. Synovial fluid cultures were negative but PCR amplification test was positive forUreaplasmaparvum. The patient was treated with doxycycline. Two and a half years later, the patient presented with shortness of breath and grade III/IV diastolic murmur on auscultation. Echocardiography revealed severely dilated left heart chambers, severe aortic regurgitation and several mobile masses on the aortic valve cusps suspected to be vegetations...
August 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28813665/lineage-restricted-mammary-stem-cells-sustain-the-development-homeostasis-and-regeneration-of-the-estrogen-receptor-positive-lineage
#7
Alexandra Van Keymeulen, Marco Fioramonti, Alessia Centonze, Gaëlle Bouvencourt, Younes Achouri, Cédric Blanpain
The mammary gland (MG) is composed of different cell lineages, including the basal and the luminal cells (LCs) that are maintained by distinct stem cell (SC) populations. LCs can be subdivided into estrogen receptor (ER)(+) and ER(-) cells. LCs act as the cancer cell of origin in different types of mammary tumors. It remains unclear whether the heterogeneity found in luminal-derived mammary tumors arises from a pre-existing heterogeneity within LCs. To investigate LC heterogeneity, we used lineage tracing to assess whether the ER(+) lineage is maintained by multipotent SCs or by lineage-restricted SCs...
August 15, 2017: Cell Reports
https://www.readbyqxmd.com/read/28812723/the-unconstrained-evolution-of-fast-and-efficient-antibiotic-resistant-bacterial-genomes
#8
Carlos Reding-Roman, Mark Hewlett, Sarah Duxbury, Fabio Gori, Ivana Gudelj, Robert Beardmore
Evolutionary trajectories are constrained by trade-offs when mutations that benefit one life history trait incur fitness costs in other traits. As resistance to tetracycline antibiotics by increased efflux can be associated with an increase in length of the Escherichia coli chromosome of 10% or more, we sought costs of resistance associated with doxycycline. However, it was difficult to identify any because the growth rate (r), carrying capacity (K) and drug efflux rate of E. coli increased during evolutionary experiments where the species was exposed to doxycycline...
January 30, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28807730/development-of-a-dual-reporter-screening-assay-for-distinguishing-the-inhibition-of-hiv-tat-mediated-transcription-from-off-target-effects
#9
YoungHyun Shin, Byeong-Sun Choi, Kyung-Chang Kim, Chun Kang, Kisoon Kim, Cheol-Hee Yoon
Human immunodeficiency virus (HIV) encodes a transcription trans-activator (Tat) with an essential role in the transcriptional elongation of viral RNA based on the viral promoter long terminal repeat (LTR). Tat-mediated transcription is conserved and can be distinguished from host transcription, so it is a therapeutic target for combating HIV replication. Traditional screening assays for Tat-mediated transcriptional inhibitors are based on the biochemical properties of Tat and transactivation-responsive RNA...
August 11, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28802854/use-of-axenic-media-to-determine-antibiotic-efficacy-against-coxiella-burnetii
#10
K A Clay, M G Hartley, P Russell, I H Norville
The traditional methods of measuring minimum inhibitory concentration (MIC) of antibiotics against Coxiella burnetii are time consuming and technically difficult. The discovery of axenic media for C. burnetii culture provided an opportunity to determine the feasibility of using both broth dilution and an antimicrobial gradient method (E-test) as a convenient method of measuring MICs. The MIC for a range of antibiotics that have proven or potential use in the treatment of Q-fever, namely doxycycline, ciprofloxacin, levofloxacin, moxifloxacin, co-trimoxazole, were measured...
August 9, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28800750/angiopoietin-1-deficiency-increases-tumor-metastasis-in-mice
#11
Iacovos P Michael, Martina Orebrand, Marta Lima, Beatriz Pereira, Olga Volpert, Susan E Quaggin, Marie Jeansson
BACKGROUND: Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of stimuli. Here, we test the hypothesis that loss of Angiopoietin-1/Tek signaling in the vasculature would increase metastasis. METHODS: Angiopoietin-1 was deleted in mice just before birth using floxed Angiopoietin-1 and Tek mice crossed to doxycycline-inducible bitransgenic ROSA-rtTA/tetO-Cre mice...
August 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28799283/selection-and-transfer-of-an-inci1-tet-a-plasmid-of-escherichia-coli-in-an-ex-vivo-model-of-the-porcine-cecum-at-doxycycline-concentrations-caused-by-cross-contaminated-feed
#12
Laura E J Peeters, Thijs De Mulder, Els Van Coillie, Judith Huygens, Annemieke Smet, Els Daeseleire, Jeroen Dewulf, Hein Imberechts, Patrick Butaye, Freddy Haesebrouck, Siska Croubels, Marc Heyndrickx, Geertrui Rasschaert
AIMS: The aim of this study was to investigate the effect of subtherapeutic intestinal doxycycline (DOX) concentrations (4 and 1 mg l(-1) ), caused by cross-contamination of feed, on the enrichment of a DOX resistant commensal E. coli and it's resistance plasmid in an ex vivo model of the porcine cecum. METHODS AND RESULTS: A DOX resistant, tet(A) carrying, porcine commensal E. coli strain (EC 682) was cultivated for 6 days in the porcine cecum model under different conditions (0, 1 and 4 mg l(-1) DOX)...
August 11, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28795656/development-and-validation-of-multi-residue-analysis-for-tetracycline-antibiotics-in-feed-by-high-performance-liquid-chromatography-coupled-to-mass-spectrometry
#13
Ewelina Patyra, Krzysztof Kwiatek
A new multi-residue method for the analysis of the tetracycline antibiotics oxytetracycline, tetracycline, chlortetracycline, and doxycycline was developed and validated for animal feed. After extraction with 0.1M Na2EDTA-McIlvaine buffer (pH 4), the samples were centrifuged, purified by SPE (Strata-X-CW cartridges) and analyzed by high-performance liquid chromatography coupled to mass spectrometry. Validation of the method was performed according to the guidelines indicated in Commission Decision 2002/657/EC...
August 10, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28795034/chemical-pleurodesis-using-doxycycline-and-viscum-album-extract
#14
Kyung Sub Song, DongYoon Keum, Jae Bum Kim
BACKGROUND: In chemical pleurodesis for managing pulmonary air leak, tetracycline derivatives are commonly used, and their effectiveness has been established in many studies. Recently, a Viscum album extract was used in chemical pleurodesis. We compared the effects of V. album with those of a tetracycline derivative (doxycycline) to demonstrate the therapeutic effectiveness of the V. album extract in chemical pleurodesis for managing pulmonary air leak. METHODS: Between October 2010 and October 2016, chemical pleurodesis was performed using doxycycline in 40 patients and the V...
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28793824/dual-therapy-deflazacort-doxycyclyne-is-better-than-deflazacort-monotherapy-to-alleviate-cardiomyopathy-in-dystrophin-deficient-mdx-mice
#15
Juliano Alves Pereira, Adriana Fogagnolo Mauricio, Maria Julia Marques, Humberto Santo Neto
Cardiomyopathy related to the absence of dystrophin is an important feature in Duchenne muscular dystrophy (DMD) and in the mdx mouse. Doxycycline (DOX) could be a potential therapy for mdx skeletal muscles dystrophy. We investigated whether the corticoid deflazacort (DFZ) plus DOX could improve cardiac mdx dystrophy better than DFZ alone, later (17 months) in dystrophy. Mdx mice (8 months old) received DFZ/DOX or DFZ for 9 months. The combined therapy was greater than DFZ in reducing fibrosis (60% decrease with DFZ/DOX and 40% with DFZ alone) in the right ventricle and transforming growth factor β levels (6...
September 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28792540/antibiotics-resistance-in-el-tor-vibrio-cholerae-01-isolated-during-cholera-outbreaks-in-mozambique-from-2012-to-2015
#16
Liliana Candida Dengo-Baloi, Cynthia Amino Semá-Baltazar, Lena Vania Manhique, Jucunu Elias Chitio, Dorteia Luísa Inguane, José Paulo Langa
RATIONALE: Mozambique has recorded cyclically epidemic outbreaks of cholera. Antibiotic therapy is recommended in specific situations for management and control of cholera outbreaks. However, an increase in resistance rates to antibiotics by Vibrio cholerae has been reported in several epidemic outbreaks worldwide. On the other hand, there are few recent records of continuous surveillance of antibiotics susceptibility pattern of V. cholerae in Mozambique. GOALS: The purpose of this study was to evaluate antibiotics resistance pattern of Vibrio cholerae O1 Ogawa isolated during Cholera outbreaks in Mozambique to commonly used antibiotics...
2017: PloS One
https://www.readbyqxmd.com/read/28791016/doxycycline-attenuates-leptospira-induced-il-1%C3%AE-by-suppressing-nlrp3-inflammasome-priming
#17
Wenlong Zhang, Xufeng Xie, Dianjun Wu, Xuemin Jin, Runxia Liu, Xiaoyu Hu, Yunhe Fu, Zhuang Ding, Naisheng Zhang, Yongguo Cao
Doxycycline (Dox), a semisynthetic antibiotic, has been reported to exert multiple immunomodulatory effects. Treatment with Dox has a satisfactory curative effect against leptospirosis. In addition to its antibacterial action, we supposed that Dox also modulated immune response in controlling leptospira infection. Using J774A.1 mouse macrophages, the effects of Dox on protein and mRNA levels of IL-1β and TNF-α were investigated after infection with live or sonicated Leptospira interrogans serovar Lai strain Lai (56601)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28783087/application-of-metal-organic-framework-nano-mil-100-fe-for-sustainable-release-of-doxycycline-and-tetracycline
#18
Seyed Dariush Taherzade, Janet Soleimannejad, Aliakbar Tarlani
Nanostructures of MIL-100 were synthesized and used as a drug delivery platform for two members of the Tetracycline family. Doxycycline monohydrate (DOX) and Tetracycline hydrochloride (TC) were loaded separately on nano-MIL-100 (nanoparticles of drug@carrier were abbreviated as DOX@MIL-100 and TC@MIL-100). Characterizations were carried out using FT-IR, XRD, BET, DLS, and SEM. The FT-IR spectra revealed that the drugs were loaded into the framework of the carrier. The XRD patterns of DOX@MIL-100 and TC@MIL-100 indicated that no free DOX or TC were present...
August 6, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28782709/mic-distribution-among-wild-type-strains-of-legionella-pneumophila-identifies-a-subpopulation-with-reduced-susceptibility-to-macrolides-owing-to-efflux-pump-genes
#19
Marine Vandewalle-Capo, Clémence Massip, Ghislaine Descours, Joséphine Charavit, Joelle Chastang, Pierre Alain Billy, Sandrine Boisset, Gerard Lina, Christophe Gilbert, Max Maurin, Sophie Jarraud, Christophe Ginevra
Legionnaires' disease is a severe pneumonia mainly caused by Legionella pneumophila, and which is treated by antibiotics. The purpose of this study was to describe the susceptibility of clinical strains of Legionella pneumophila to seven antibiotics used for legionellosis treatment. The minimum inhibitory concentrations (MICs) of 109 well-characterized clinical strains of L. pneumophila serogroup-1 were determined using a broth microdilution method without charcoal and compared to antibiotic-resistant strains selected in vitro...
August 4, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28782506/an-inducible-form-of-nrf2-confers-enhanced-protection-against-acute-oxidative-stresses-in-rpe-cells
#20
Khiem T Vu, John D Hulleman
Increasing evidence suggests that overt oxidative stress within the retina plays an important role in the progression of age-related retinal decline, and in particular, in the disease age-related macular degeneration (AMD). Nuclear factor erythroid 2-like 2 (Nrf2) is a master transcription factor that upregulates numerous of antioxidant/detoxification genes. Nrf2(-/-) mice develop progressive retinal degeneration that includes the formation of drusen-like deposits, lipofuscin, and sub-retinal pigment epithelium (RPE) deposition of inflammatory proteins...
August 4, 2017: Experimental Eye Research
keyword
keyword
8095
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"