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https://www.readbyqxmd.com/read/28718666/atrial-cardiopathy-a-mechanism-of-cryptogenic-stroke
#1
Shadi Yaghi, Hooman Kamel, Mitchell S V Elkind
Cryptogenic stroke accounts for approximately 30% of all ischemic strokes. Recently, atrial cardiopathy diagnosed by the presence of one of its serum, imaging, or electrocardiogram biomarkers has been shown to be associated with ischemic stroke, particularly of embolic subtypes. Areas covered: This paper aims to summarize data on occult atrial fibrillation and stroke, provide an overview on mechanisms, such as inflammation and fibrosis, of stroke in atrial cardiopathy, critically review data on biomarkers of atrial cardiopathy and their association with stroke, and suggest therapeutic implications, including directions for future research...
July 18, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28666806/pr-interval-prolongation-and-cryptogenic-stroke-a-multicenter-retrospective-study
#2
Mayra Montalvo, Prasanna Tadi, Alexander Merkler, Gino Gialdini, Sheryl Martin-Schild, Digvijaya Navalkele, Alyana Samai, Amre Nouh, Mohammad Hussain, Steven Goldblatt, Morgan Hemendinger, Antony Chu, Christopher Song, Hooman Kamel, Karen L Furie, Shadi Yaghi
BACKGROUND: Atrial dysfunction or "cardiopathy" has been recently proposed as a mechanism in cryptogenic stroke. A prolonged PR interval may reflect impaired atrial conduction and thus may be a biomarker of atrial cardiopathy. We aim to compare the prevalence of PR interval prolongation in patients with cryptogenic stroke (CS) when compared with known non-cryptogenic non-cardioembolic stroke (NCNCS) subtypes. METHODS: We used prospective ischemic stroke databases of 3 comprehensive stroke centers to identify patients 18 years or older with a discharge diagnosis of ischemic non-cardioembolic stroke between December 1, 2013 and August 31, 2015...
June 27, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28524259/nonpegylated-liposomal-doxorubicin-combination-regimen-in-patients-with-diffuse-large-b-cell-lymphoma-and-cardiac-comorbidity-results-of-the-heart01-phase-ii-trial-conducted-by-the-fondazione-italiana-linfomi
#3
Stefano Luminari, Elda Viel, Andrés José Maria Ferreri, Francesco Zaja, Emanuela Chimienti, Gerardo Musuraca, Alessandra Tucci, Monica Balzarotti, Monica Tani, Francesca Salvi, Emanuela A Pesce, Angela Ferrari, Anna M Liberati, Antonio Spadea, Dario Marino, Maria Bruno-Ventre, Stefano Volpetti, Chiara Bottelli, Elena Ravaioli, Francesco Merli, Michele Spina
The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of "R-COMP" combination in patients with diffuse large B-cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76 years). Median baseline left ventricular ejection fraction (LVEF) was 60%...
May 19, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28320124/the-p-wave-terminal-force-in-embolic-strokes-of-undetermined-source
#4
Simona Lattanzi, Claudia Cagnetti, Alessandra Pulcini, Marco Morelli, Simone Maffei, Leandro Provinciali, Mauro Silvestrini
BACKGROUND: The Embolic Stroke of Undetermined Source (ESUS) is a recently developed clinical construct which describes stroke patients for whom the embolic source remains undetermined despite recommended investigations. The aim of the study was to characterize the ESUS population according to the abnormality in the P-wave terminal force in lead V1 (PTFV1). METHODS: We retrospectively identified consecutive patients hospitalized for acute ischemic stroke who met the ESUS diagnostic criteria...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28237125/biomarkers-of-atrial-cardiopathy-and-atrial-fibrillation-detection-on-mobile-outpatient-continuous-telemetry-after-embolic-stroke-of-undetermined-source
#5
Denise Sebasigari, Alexander Merkler, Yang Guo, Gino Gialdini, Benjamin Kummer, Morgan Hemendinger, Christopher Song, Antony Chu, Shawna Cutting, Brian Silver, Mitchell S V Elkind, Hooman Kamel, Karen L Furie, Shadi Yaghi
BACKGROUND: Biomarkers of atrial dysfunction or "cardiopathy" are associated with embolic stroke risk. However, it is unclear if this risk is mediated by undiagnosed paroxysmal atrial fibrillation or flutter (AF). We aim to determine whether atrial cardiopathy biomarkers predict AF on continuous heart-rhythm monitoring after embolic stroke of undetermined source (ESUS). METHODS: This was a single-center retrospective study including all patients with ESUS undergoing 30 days of ambulatory heart-rhythm monitoring to look for AF between January 1, 2013 and December 31, 2015...
June 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28154102/cryptogenic-stroke-research-and-practice
#6
REVIEW
Shadi Yaghi, Richard A Bernstein, Rod Passman, Peter M Okin, Karen L Furie
BACKGROUND: Cryptogenic stroke accounts for 30% to 40% of ischemic stroke. It is essential to determine the possible culprit because this will improve secondary stroke prevention strategies. METHODS: We performed a narrative nonsystematic review of the literature that included randomized trials, exploratory comparative studies, and case series on cryptogenic stroke. RESULTS: There are several possible mechanisms implicated in cryptogenic stroke, including occult paroxysmal atrial fibrillation, patent foramen ovale, aortic arch atherosclerosis, atrial cardiopathy, and substenotic atherosclerosis...
February 3, 2017: Circulation Research
https://www.readbyqxmd.com/read/27847992/-esc-guidelines-on-atrial-fibrillation-2016-summary-of-the-most-relevant-recommendations-and-modifications
#7
REVIEW
L Eckardt, K G Häusler, U Ravens, M Borggrefe, P Kirchhof
The first European Society of Cardiology (ESC) guidelines on atrial fibrillation (AF) developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS) were published in August 2016. These guidelines replace the revised guidelines from 2012 and contain some interesting new aspects. The topics range from the pathophysiology through diagnostics, therapy and stroke prevention up to special clinical situations, such as atrial fibrillation in cardiopathy, sport and pregnancy. Early screening, patient informed consent, individualized therapy and the modification of factors promoting atrial fibrillation are of particular importance...
December 2016: Herz
https://www.readbyqxmd.com/read/26559982/palliative-senning-in-the-treatment-of-congenital-heart-disease-with-severe-pulmonary-hypertension
#8
Juliano Gomes da Penha, Leina Zorzanelli, Antonio Augusto Barbosa-Lopes, Edimar Atik, Leonardo Augusto Miana, Carla Tanamati, Luiz Fernando Caneo, Nana Miura, Vera Demarchi Aiello, Marcelo Biscegli Jatene
BACKGROUND: Transposition of the great arteries (TGA) is the most common cyanotic cardiopathy, with an incidence ranging between 0.2 and 0.4 per 1000 live births. Many patients not treated in the first few months of life may progress with severe pulmonary vascular disease. Treatment of these patients may include palliative surgery to redirect the flow at the atrial level. OBJECTIVE: Report our institutional experience with the palliative Senning procedure in children diagnosed with TGA and double outlet right ventricle with severe pulmonary vascular disease, and to evaluate the early and late clinical progression of the palliative Senning procedure...
October 2015: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/26482625/-partial-anomalous-pulmonary-venous-return-in-a-64-year-old-woman
#9
F Aboukhoudir, I Aboukhoudir, M Pansieri, B Khennine, J L Hirsch, S Rekik
Partial anomalous pulmonary venous return (PAPVR) represents 3 % of the congenital cardiopathies. Diagnosis in adults is challenging as clinical symptomatology is non-specific and echocardiographic signs are discrete and misleading potentially confusing with idiopathic pulmonary hypertension. We report the case of a 64-year-old woman in whom we diagnosed PAPVR associated with sinus venosus atrial septal defect. We describe medical history, clinical signs, investigations and postoperative evolution.
November 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26476588/atrial-cardiopathy-and-cryptogenic-stroke-a-cross-sectional-pilot-study
#10
Shadi Yaghi, Amelia K Boehme, Rebecca Hazan, Eldad A Hod, Alberto Canaan, Howard F Andrews, Hooman Kamel, Randolph S Marshall, Mitchell S V Elkind
BACKGROUND: There is increasing evidence that left atrial dysfunction or cardiopathy is associated with ischemic stroke risk independently of atrial fibrillation. We aimed to determine the prevalence of atrial cardiopathy biomarkers in patients with cryptogenic stroke. METHODS: We included consecutive patients with ischemic stroke enrolled in the New York Columbia Collaborative Specialized Program of Translational Research in Acute Stroke registry between December 1, 2008, and April 30, 2012...
January 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/26291842/palliative-senning-in-the-treatment-of-congenital-heart-disease-with-severe-pulmonary-hypertension
#11
Juliano Gomes da Penha, Leina Zorzanelli, Antonio Augusto Barbosa-Lopes, Edimar Atik, Leonardo Augusto Miana, Carla Tanamati, Luiz Fernando Caneo, Nana Miura, Vera Demarchi Aiello, Marcelo Biscegli Jatene
BACKGROUND: Transposition of the great arteries (TGA) is the most common cyanotic cardiopathy, with an incidence ranging between 0.2 and 0.4 per 1000 live births. Many patients not treated in the first few months of life may progress with severe pulmonary vascular disease. Treatment of these patients may include palliative surgery to redirect the flow at the atrial level. OBJECTIVE: Report our institutional experience with the palliative Senning procedure in children diagnosed with TGA and double outlet right ventricle with severe pulmonary vascular disease, and to evaluate the early and late clinical progression of the palliative Senning procedure...
August 18, 2015: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/26179566/electrocardiographic-left-atrial-abnormality-and-stroke-subtype-in-the-atherosclerosis-risk-in-communities-study
#12
Hooman Kamel, Wesley T O'Neal, Peter M Okin, Laura R Loehr, Alvaro Alonso, Elsayed Z Soliman
OBJECTIVE: The aim of this study was to assess the relationship between abnormally increased P-wave terminal force in lead V1 , an electrocardiographic (ECG) marker of left atrial abnormality, and incident ischemic stroke subtypes. We hypothesized that associations would be stronger with nonlacunar stroke, given that we expected left atrial abnormality to reflect the risk of thromboembolism rather than in situ cerebral small-vessel occlusion. METHODS: Our cohort comprised 14,542 participants 45 to 64 years of age prospectively enrolled in the Atherosclerosis Risk in Communities study and free of clinically apparent atrial fibrillation (AF) at baseline...
November 2015: Annals of Neurology
https://www.readbyqxmd.com/read/26147524/the-murine-model-of-mucopolysaccharidosis-iiib-develops-cardiopathies-over-time-leading-to-heart-failure
#13
Gabriele Giacomo Schiattarella, Giuliana Cerulo, Valeria De Pasquale, Pasquale Cocchiaro, Orlando Paciello, Luigi Avallone, Maria Paola Belfiore, Francesca Iacobellis, Daniele Di Napoli, Fabio Magliulo, Cinzia Perrino, Bruno Trimarco, Giovanni Esposito, Paola Di Natale, Luigi Michele Pavone
Mucopolysaccharidosis (MPS) IIIB is a lysosomal disease due to the deficiency of the enzyme α-N-acetylglucosaminidase (NAGLU) required for heparan sulfate (HS) degradation. The disease is characterized by mild somatic features and severe neurological disorders. Very little is known on the cardiac dysfunctions in MPS IIIB. In this study, we used the murine model of MPS IIIB (NAGLU knockout mice, NAGLU(-/-)) in order to investigate the cardiac involvement in the disease. Echocardiographic analysis showed a marked increase in left ventricular (LV) mass, reduced cardiac function and valvular defects in NAGLU(-/-) mice as compared to wild-type (WT) littermates...
2015: PloS One
https://www.readbyqxmd.com/read/26021638/atrial-cardiopathy-a-broadened-concept-of-left-atrial-thromboembolism-beyond-atrial-fibrillation
#14
REVIEW
Hooman Kamel, Peter M Okin, W T Longstreth, Mitchell S V Elkind, Elsayed Z Soliman
Atrial fibrillation (AF) has long been associated with a heightened risk of ischemic stroke and systemic thromboembolism, but recent data require a re-evaluation of our understanding of the nature of this relationship. New findings about the temporal connection between AF and stroke, alongside evidence linking markers of left atrial abnormalities with stroke in the absence of apparent AF, suggest that left atrial thromboembolism may occur even without AF. These observations undermine the hypothesis that the dysrhythmia that defines AF is necessary and sufficient to cause thromboembolism...
May 2015: Future Cardiology
https://www.readbyqxmd.com/read/25702240/-echographic-diagnosis-of-systolic-murmur-among-280-young-french-militaries-implications-for-the-expertise-in-military-medicine
#15
U Vinsonneau, L Vermeulen, V Griffet, A Delluc, N Paleiron, F Le Ven, G Rohel, Y Jobic, M Piquemal, J Mansourati, P Paule
UNLABELLED: Clinically discovering a systolic murmur is frequent among the young military population. When this murmur does not sound benign, a transthoracic echocardiography (TTE) is made to detect any cardiopathy, which could cause sudden cardiac death. The aim of this study was to evaluate the interest of systematic TTE in the assessment of any cardiac systolic murmur (CSM) among militaries. METHODS: We ran a retrospective monocentric study in the "Clermont-Tonnerre" military hospital in Brest...
April 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/25052322/p-wave-morphology-and-the-risk-of-incident-ischemic-stroke-in-the-multi-ethnic-study-of-atherosclerosis
#16
Hooman Kamel, Elsayed Z Soliman, Susan R Heckbert, Richard A Kronmal, W T Longstreth, Saman Nazarian, Peter M Okin
BACKGROUND AND PURPOSE: Emerging data suggest that left atrial disease may cause ischemic stroke in the absence of atrial fibrillation or flutter (AF). If true, this condition may provide a cause for many strokes currently classified as cryptogenic. METHODS: Among 6741 participants in the Multi-Ethnic Study of Atherosclerosis who were free of clinically apparent cerebrovascular or cardiovascular disease (including AF) at baseline, we examined the association between markers of left atrial abnormality on a standard 12-lead ECG-specifically P-wave area, duration, and terminal force in lead V1-and the subsequent risk of ischemic stroke while accounting for incident AF...
September 2014: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/24998101/simultaneous-transcatheter-treatment-of-perimembranous-ventricular-septal-defect-and-other-congenital-cardiopathies
#17
Xu-Dong Xu, Yuan Bai, Xiao-Li Chen, Su-Xuan Liu, Xian-Xian Zhao, Yong-Wen Qin
OBJECTIVE: To assess the efficacy and safety of simultaneous transcatheter corrections of perimembranous ventricular septal defect (VSD) and other congenital cardiopathies. PATIENTS/METHODS: From 2004 to 2012, 56 patients (25 male, 31 female), aged 14.2±10.1, with compound congenital cardiovascular abnormalities underwent simultaneous transcatheter interventional procedure. Of the 56 patients, 32 had VSD and atrial septal defects (ASD); 17 had VSD and patent ductus arteriosus (PDA); and seven had VSD and pulmonary valve stenosis (PS)...
December 2014: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/24831764/ablation-of-typical-atrial-flutter-a-prospective-study-of-cooled-tip-versus-8-mm-tip-catheters
#18
MULTICENTER STUDY
M Iori, N Bottoni, F Quartieri, B Sassone, S Guerzoni
AIM: Both ablation catheters with irrigated system and 8mm tip-catheters have shown to be more effective for typical atrial flutter radiofrequency (RF) ablation when compared to conventional 4 mm tip catheter. The purpose of this prospective study was to compare the efficiency of radiofrequency catheter ablation (RFA) of the cavotricuspid isthmus using a new type of open irrigation-tip catheter versus 8 mm tip-catheters to eliminate atrial flutter (AFL). METHODS: Sixty consecutive patients, matched for age, presence of cardiopathy, atrial dimensions and comorbidity, underwent RF ablation of cavotricuspid isthmus (CTI) for the treatment of typical atrial flutter, using an open irrigated tip catheter - Surround Flow™ - (N...
June 2014: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/24594551/comprehensive-geriatric-assessment-and-2-year-mortality-in-elderly-patients-hospitalized-for-heart-failure
#19
Carlos Rodriguez-Pascual, Emilio Paredes-Galan, Arturo Vilches-Moraga, Ana Isabel Ferrero-Martinez, Marta Torrente-Carballido, Fernando Rodriguez-Artalejo
BACKGROUND: In older adults hospitalized for heart failure, a poor score on a comprehensive geriatric assessment (CGA) is associated with worse prognosis during hospitalization and at 1 month after discharge. However, the association between the CGA score and long-term mortality is uncertain. METHODS AND RESULTS: This is a prospective study of 487 patients aged ≥75 years admitted for decompensated heart failure. At discharge, a CGA score (range, 0-10) was calculated based on limitation in activities of daily living, mobility limitation, comorbidity, cognitive decline, and previous medication use...
March 2014: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/24286964/simplified-progressive-approach-for-the-ablation-of-scar-related-atrial-macroreentrant-tachycardias
#20
Santiago Nava, Pedro Iturralde-Torres, Manlio F Márquez, Jorge Gómez-Flores, Bernardo Cline, Luis Colin-Lizalde, Diana Victoria, Antonio G Hermosillo
INTRODUCTION: Radiofrequency ablation of scar related right atrial flutter is challenging. Long procedures, prolonged fluoroscopic times and high percentages of recurrences are of concern. We present a simple and progressive approach based on a single electroanatomic map of the right atrium. METHODS: Twenty-two consecutive patients with atrial flutter and history of cardiac surgery were included. An electrophysiologic study was performed to define localization (left or right) and cavo-tricuspid isthmus participation using entrainment mapping...
October 2013: Archivos de Cardiología de México
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