Janev Fehmi, Alexander J Davies, Marilina Antonelou, Stephen Keddie, Sonja Pikkupeura, Luis Querol, Emilien Delmont, Andrea Cortese, Diego Franciotta, Staffan Persson, Jonathan Barratt, Ruth Pepper, Filipa Farinha, Anisur Rahman, Diana Canetti, Janet A Gilbertson, Nigel B Rendell, Aleksandar Radunovic, Thomas Minton, Geraint Fuller, Sinead M Murphy, Aisling S Carr, Mary R Reilly, Filip Eftimov, Luuk Wieske, Charlotte E Teunissen, Ian S D Roberts, Neil Ashman, Alan D Salama, Simon Rinaldi
Membranous glomerulonephritis (MGN) is a common cause of nephrotic syndrome in adults, mediated by glomerular antibody deposition to an increasing number of newly recognised antigens. Previous case reports have suggested an association between patients with anti-contactin-1 (CNTN1)-mediated neuropathies and MGN. In an observational study we investigated the pathobiology and extent of this potential cause of MGN by examining the association of antibodies against CNTN1 with the clinical features of a cohort of 468 patients with suspected immune-mediated neuropathies, 295 with idiopathic MGN, and 256 controls...
2023: PloS One