keyword
https://read.qxmd.com/read/38479178/decoupling-the-mutual-promotion-of-inflammation-and-oxidative-stress-mitigates-cognitive-decline-and-depression-like-behavior-in-rmtbi-mice-by-promoting-myelin-renewal-and-neuronal-survival
#21
JOURNAL ARTICLE
Shenghua Lu, QianQian Ge, MengShi Yang, Yuan Zhuang, Xiaojian Xu, Fei Niu, Baiyun Liu, Runfa Tian
BACKGROUND: Repetitive mild traumatic brain injury (rmTBI) can lead to somatic, emotional, and cognitive symptoms that persist for years after the initial injury. Although the ability of various treatments to promote recovery after rmTBI has been explored, the optimal time window for early intervention after rmTBI is unclear. Previous research has shown that hydrogen-rich water (HRW) can diffuse through the blood-brain - barrier, attenuate local oxidative stress, and reduce neuronal apoptosis in patients with severe traumatic brain injury...
March 12, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38466640/bmscs-derived-exosomes-inhibit-macrophage-microglia-pyroptosis-by-increasing-autophagy-through-the-mir-21a-5p-peli1-axis-in-spinal-cord-injury
#22
JOURNAL ARTICLE
Jun Gu, Jingyi Wu, Chunming Wang, Zhenwei Xu, Zhengshuai Jin, Donghua Yan, Sheng Chen
Spinal cord injury (SCI) results in a diverse range of disabilities and lacks effective treatment options. In recent years, exosomes derived from bone mesenchymal stem cells (BMSCs) have emerged as a promising cell-free therapeutic approach for treating ischemic brain injury and other inflammatory conditions. Macrophage/microglial pyroptosis has been identified as a contributing factor to neuroinflammation following SCI. The therapeutic potential of BMSC-derived exosomes in macrophage/microglia pyroptosis-induced neuroinflammation, however, has to be determined...
March 11, 2024: Aging
https://read.qxmd.com/read/38464118/nf-%C3%AE%C2%BAb-nlrp3-translational-inhibition-by-nanoligomer-therapy-mitigates-ethanol-and-advanced-age-related-neuroinflammation
#23
Paige E Anton, Prashant Nagpal, Julie Moreno, Matthew A Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J Kovacs, Rebecca L McCullough
Binge alcohol use is increasing among aged adults (>65 years). Alcohol-related toxicity in aged adults is associated with neurodegeneration, yet the molecular underpinnings of age-related sensitivity to alcohol are not well described. Studies utilizing rodent models of neurodegenerative disease reveal heightened activation of Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and Nod like receptor 3 (NLRP3) mediate microglia activation and associated neuronal injury. Our group, and others, have implicated hippocampal-resident microglia as key producers of inflammatory mediators, yet the link between inflammation and neurodegeneration has not been established in models of binge ethanol exposure and advanced age...
February 28, 2024: bioRxiv
https://read.qxmd.com/read/38460120/editorial-for-effects-of-gadolinium-retention-in-the-brains-of-type-2-diabetic-rats-after-repeated-administration-of-gadolinium-based-mri-contrast-agents-on-neurobiology-and-nlrp3-inflammasome-activation
#24
EDITORIAL
https://read.qxmd.com/read/38449739/the-role-of-gut-microorganisms-and-metabolites-in-intracerebral-hemorrhagic-stroke-a-comprehensive-review
#25
REVIEW
Xin Wen, Hao Dong, Wei Zou
Intracerebral hemorrhagic stroke, characterized by acute hemorrhage in the brain, has a significant clinical prevalence and poses a substantial threat to individuals' well-being and productivity. Recent research has elucidated the role of gut microorganisms and their metabolites in influencing brain function through the microbiota-gut-brain axis (MGBA). This article provides a comprehensive review of the current literature on the common metabolites, short-chain fatty acids (SCFAs) and trimethylamine-N-oxide (TMAO), produced by gut microbiota...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38445502/inhibition-of-anaplastic-lymphoma-kinase-protects-from-ischemic-stroke
#26
JOURNAL ARTICLE
Yue Hu, Luping Chang, Yuanbo Zhu, Xue Geng, Zhongwang Liu, Ranran Wang, Yiheng Wang, Bing-Qiao Zhao, Wenying Fan
BACKGROUND: Ischemic stroke is often accompanied by oxidative stress and inflammatory response, both of which work synergistically to exacerbate the disruption of the blood-brain barrier and ischemic brain injury. ALK (anaplastic lymphoma kinase), a cancer-associated receptor tyrosine kinase, was found to play a role in oxidative stress and inflammation. In this study, we investigated the role of ALK inhibition in a murine model of ischemic stroke. METHODS: Focal cerebral ischemia was induced by temporary occlusion of the right middle cerebral artery in mice with a filament...
March 6, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38445369/beneficial-effects-of-human-schwann-cell-derived-exosomes-in-mitigating-secondary-damage-after-penetrating-ballistic-like-brain-injury
#27
JOURNAL ARTICLE
Kengo Nishimura, Juliana Sanchez, Nadine Kerr, Yelena Pressman, Risset Silvera, Aisha Khan, Shyam Gajavelli, Helen M Bramlett, W Dalton Dietrich
There is a growing body of evidence that the delivery of cell-derived exosomes normally involved in intracellular communication can reduce secondary injury mechanisms after brain and spinal cord injury and improve outcomes. Exosomes are nanometer-sized vesicles that released by Schwann cells may have neuroprotective effects by reducing posttraumatic inflammatory processes as well as promoting tissue healing and functional recovery. The purpose of this study was to evaluate the beneficial effects of human Schwann-cell exosomes (hSC-Exos) in a severe model of penetrating ballistic-like brain injury (PBBI) in rats and investigate effects on multiple outcomes...
March 6, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38444608/p2x7-receptor-inhibition-alleviates-mania-like-behavior-independently-of-interleukin-1%C3%AE
#28
JOURNAL ARTICLE
Flóra Gölöncsér, Mária Baranyi, Pál Tod, Fruzsina Maácz, Beáta Sperlágh
Purinergic dysfunctions are associated with mania and depression pathogenesis. P2X7 receptor (P2X7R) mediates the IL-1β maturation via NLRP3 inflammasome activation. We tested in a mouse model of the subchronic amphetamine (AMPH)-induced hyperactivity whether P2X7R inhibition alleviated mania-like behavior through IL-1β. Treatment with JNJ-47965567, a P2X7R antagonist, abolished AMPH-induced hyperlocomotion in wild-type and IL-1α/β-knockout male mice. The NLRP3 inhibitor MCC950 failed to reduce AMPH-induced locomotion in WT mice, whereas the IL-1 receptor antagonist anakinra slightly increased it...
March 15, 2024: IScience
https://read.qxmd.com/read/38438515/toxoplasma-gondii-infection-associated-with-inflammasome-activation-and-neuronal-injury
#29
JOURNAL ARTICLE
Dimitrios Andreou, Nils Eiel Steen, Lynn Mørch-Johnsen, Kjetil Nordbø Jørgensen, Laura A Wortinger, Claudia Barth, Attila Szabo, Kevin S O'Connell, Tove Lekva, Gabriela Hjell, Ingrid Torp Johansen, Monica B E G Ormerod, Unn K Haukvik, Pål Aukrust, Srdjan Djurovic, Robert H Yolken, Ole A Andreassen, Thor Ueland, Ingrid Agartz
Toxoplasma gondii (TOXO) infection typically results in chronic latency due to its ability to form cysts in the brain and other organs. Latent toxoplasmosis could promote innate immune responses and impact brain function. A large body of evidence has linked TOXO infection to severe mental illness (SMI). We hypothesized that TOXO immunoglobulin G (IgG) seropositivity, reflecting previous infection and current latency, is associated with increased circulating neuron-specific enolase (NSE), a marker of brain damage, and interleukin-18 (IL-18), an innate immune marker, mainly in SMI...
March 4, 2024: Scientific Reports
https://read.qxmd.com/read/38438086/microrna-7-attenuates-secondary-brain-injury-following-experimental-intracerebral-hemorrhage-via-inhibition-of-nlrp3
#30
JOURNAL ARTICLE
Bo Luo, Lin Li, Xu-Dong Song, Hua-Xuan Chen, De-Bo Yun, Lin Wang, Yuan Zhang
BACKGROUND AND PURPOSE: The pathophysiological mechanisms underlying brain injury resulting from intracerebral hemorrhage (ICH) remain incompletely elucidated, and efficacious therapeutic interventions to enhance the prognosis of ICH patients are currently lacking. Previous research indicates that MicroRNA-7 (miR-7) can suppress the expression of Nod-like receptor protein 3 (NLRP3), thereby modulating neuroinflammation in Parkinson's disease pathogenesis. However, the potential regulatory effects miR-7 on NLRP3 inflammasome after ICH are yet to be established...
March 2, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38428714/lipopolysaccharide-induced-intestinal-inflammation-on-aim2-mediated-pyroptosis-in-the-brain-of-rats-with-cerebral-small-vessel-disease
#31
JOURNAL ARTICLE
Huiping Xu, Han Xiao, Qiqiang Tang
Cerebral small vessel disease (CSVD) is a cerebral vascular disease with insidious onset and poor clinical treatment effect, the disease is related to neuroinflammation. This study investigated whether lipopolysaccharide-induced intestinal inflammation enhanced the level of pyroptosis in the brain of rats with CSVD. The bilateral carotid artery occlusion (BCAO) model was selected as the object of study. Firstly, behavioral tests and Hematoxylin-eosin staining (HE staining) were performed to determine whether the model was successful, and then AIM2-mediated inflammasome and pyroptosis indexes(GSDMD、N-GSDMD)in brain tissue were detected by Western blotting and Immunohistochemistry...
February 28, 2024: Experimental Neurology
https://read.qxmd.com/read/38420589/s100a9-aggravates-early-brain-injury-after-subarachnoid-hemorrhage-via-inducing-neuroinflammation-and-inflammasome-activation
#32
JOURNAL ARTICLE
Guijun Wang, Kesheng Huang, Qi Tian, Yujia Guo, Chengli Liu, Zhijie Li, Zhui Yu, Zhan Zhang, Mingchang Li
Subarachnoid hemorrhage (SAH) is a stroke subtype with high mortality, and its severity is closely related to the short-term prognosis of SAH patients. S100 calcium-binding protein A9 (S100A9) has been shown to be associated with some neurological diseases. In this study, the concentration of S100A9 in clinical cerebrospinal fluid samples was detected by enzyme-linked immunosorbent assay (ELISA), and the relationship between S100A9 and the prognosis of patients was explored. In addition, WT mice and S100A9 knockout mice were used to establish an in vivo SAH model...
March 15, 2024: IScience
https://read.qxmd.com/read/38419842/g-csf-increases-calprotectin-expression-liver-damage-and-neuroinflammation-in-a-murine-model-of-alcohol-induced-aclf
#33
JOURNAL ARTICLE
Martí Ortega-Ribera, Yuan Zhuang, Veronika Brezani, Prashanth Thevkar Nagesh, Radhika S Joshi, Mrigya Babuta, Yanbo Wang, Gyongyi Szabo
Background and aims: Granulocyte colony-stimulating factor (G-CSF) has been proposed as a therapeutic option for patients with ACLF, however clinical outcomes are controversial. We aimed at dissecting the role of G-CSF in an alcohol-induced murine model of ACLF. Methods : ACLF was triggered by a single alcohol binge (5 g/kg) in a bile duct ligation (BDL) liver fibrosis model. A subgroup of mice received two G-CSF (200 μg/kg) or vehicle injections prior to acute decompensation with alcohol. Liver, blood and brain tissues were assessed...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38411637/calcitriol-attenuates-lipopolysaccharide-induced-neuroinflammation-and-depressive-like-behaviors-by-suppressing-the-p2x7r-nlrp3-caspase-1-pathway
#34
JOURNAL ARTICLE
Changshui Wang, Changmeng Cui, Xin Xie, Beibei Chen, Lei Feng, Pei Jiang
RATIONALE: Microglia-mediated neuroinflammation is a vital hallmark in progression of depression, while calcitriol exerts anti-inflammatory effects in the brain. The activation of the P2X7 receptor has an important link to neuroinflammation. However, it is unclear whether calcitriol treatment exerts anti-inflammatory effects in association with P2X7R activation. OBJECTIVE: In this study, we assessed the antidepressive and neuroprotective effects of calcitriol on lipopolysaccharide (LPS)-mediated depressive-like behavior, neuroinflammation, and neuronal damage...
February 27, 2024: Psychopharmacology
https://read.qxmd.com/read/38409729/the-mechanism-of-astragaloside-iv-in-nod-like-receptor-family-pyrin-domain-containing-3-inflammasome-mediated-pyroptosis-after-intracerebral-hemorrhage
#35
JOURNAL ARTICLE
Honggang Wu, Shu Chen, Guoliang You, Bo Lei, Li Chen, Jiachuan Wu, Niandong Zheng, Chao You
BACKGROUND: Intracerebral hemorrhage (ICH) is one of the most common subtypes of stroke. OBJECTIVES: This study aimed to investigate the mechanism of Astragaloside IV (AS-IV) on inflammatory injury after ICH. METHODS: The ICH model was established by the injection of collagenase and treated with ASIV (20 mg/kg or 40 mg/kg). The neurological function, water content of the bilateral cerebral hemisphere and cerebellum, and pathological changes in brain tissue were assessed...
February 22, 2024: Current Neurovascular Research
https://read.qxmd.com/read/38409076/differential-contribution-of-thik-1-k-channels-and-p2x7-receptors-to-atp-mediated-neuroinflammation-by-human-microglia
#36
JOURNAL ARTICLE
Ali Rifat, Bernardino Ossola, Roland W Bürli, Lee A Dawson, Nicola L Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L Heppner, Jörg R P Geiger, Christian Madry
Neuroinflammation is highly influenced by microglia, particularly through activation of the NLRP3 inflammasome and subsequent release of IL-1β. Extracellular ATP is a strong activator of NLRP3 by inducing K+ efflux as a key signaling event, suggesting that K+ -permeable ion channels could have high therapeutic potential. In microglia, these include ATP-gated THIK-1 K+ channels and P2X7 receptors, but their interactions and potential therapeutic role in the human brain are unknown. Using a novel specific inhibitor of THIK-1 in combination with patch-clamp electrophysiology in slices of human neocortex, we found that THIK-1 generated the main tonic K+ conductance in microglia that sets the resting membrane potential...
February 26, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38401846/inhibition-of-piezo1-prevents-chronic-cerebral-hypoperfusion-induced-cognitive-impairment-and-blood-brain-barrier-disruption
#37
JOURNAL ARTICLE
Fei Xu, Qing Xin, Mengyao Ren, Peixin Shi, Bing Wang
Chronic cerebral hypoperfusion (CCH) plays a critical role in the onset and progression of vascular dementia (VD), which is now recognized as the second most common form of dementia after Alzheimer's disease (AD). The mechanosensitive piezo1 channel has been identified to play important roles in several neurological disorders. However, the roles and possible mechanisms of piezo1 in CCH-induced cognitive decline and blood brain barrier (BBB) disruption, as well as the underlying mechanisms remain elusive. In this study, the CCH model was established by bilateral common carotid artery occlusion in rats and by oxygen and glucose deprivation/reoxygenation (OGD/R) in bEnd...
February 22, 2024: Neurochemistry International
https://read.qxmd.com/read/38400865/the-role-of-nlrp6-in-the-development-and-progression-of-neurological-diseases
#38
REVIEW
Yiming Guo, Jiaqi Song, Mengyu Yan, Yingxi Chen, Lihong Huang, Jiarui Liu, Yurou He, Yang Lü, Weihua Yu
The nervous system possesses the remarkable ability to undergo changes in order to store information; however, it is also susceptible to damage caused by invading pathogens or neurodegenerative processes. As a member of nucleotide-binding oligomerization domain-like receptor (NLR) family, the NLRP6 inflammasome serves as a cytoplasmic innate immune sensor responsible for detecting microbe-associated molecular patterns. Upon activation, NLRP6 can recruit the adapter protein apoptosis-associated speck-like protein (ASC) and the inflammatory factors caspase-1 or caspase-11...
February 24, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38400842/effects-of-gadolinium-retention-in-the-brains-of-type-2-diabetic-rats-after-repeated-administration-of-gadolinium-based-mri-contrast-agents-on-neurobiology-and-nlrp3-inflammasome-activation
#39
JOURNAL ARTICLE
Xiang Yao, Haoran Zhang, Jingyi Hu, Xiaoning Lin, Jin Sun, Junlong Kang, Zhichun Huang, Guangsong Wang, Xinhua Tian, E Chen, Ke Ren
BACKGROUND: The neurotoxic potential of gadolinium (Gd)-based contrast agents (GBCAs) retention in the brains of patients with type 2 diabetes mellitus (T2DM) is unclear. PURPOSE: To determine the deposition and clearance of GBCAs in T2DM rats and the mechanism by which Gd enhances nucleotide-binding oligomerization domain-3 (NLRP3) inflammasome activation. STUDY TYPE: Cross-sectional, prospective. ANIMAL MODEL: 104 T2DM male Wistar rats...
February 24, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38395608/isoliquiritigenin-attenuates-neuroinflammation-after-subarachnoid-hemorrhage-through-inhibition-of-nf-%C3%AE%C2%BAb-mediated-nlrp3-inflammasome-activation
#40
JOURNAL ARTICLE
Zhang Wenfei, Tao Xiang, Chen Chen, Tao Yang, Tao Yun, Chen Zhibiao, Zhang Ge
Neuroinflammation contributes to neurological dysfunction in the patients who suffer from subarachnoid hemorrhage (SAH). Isoliquiritigenin (ISL) is a bioactive component extracted from Genus Glycyrrhiza. This work is to investigate whether ISL ameliorates neuroinflammation after SAH. In this study, intravascular perforation of male Sprague-Dawley rats was used to establish a SAH model. ISL was administered by intraperitoneal injection 6 h after SAH in rats. The mortality, SAH grade, neurological score, brain water content, and blood-brain barrier (BBB) permeability were examined at 24 h after the treatment...
February 2024: Chemical Biology & Drug Design
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