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https://www.readbyqxmd.com/read/29032660/recombinant-attenuated-salmonella-pullorum-strain-expressing-the-hemagglutinin-neuraminidase-hn-protein-of-newcastle-disease-virus-ndv-protects-chickens-against-ndv-and-salmonella-pullorum-challenge
#1
Ke Ding, Ke Shang, Zu-Hua Yu, Chuan Yu, Yan-Yan Jia, Lei He, Cheng-Shui Liao, Jing Li, Chun-Jie Zhang, Yin-Ju Li, Ting-Cai Wu, Xiang-Chao Cheng
Newcastle disease virus (NDV) and Salmonella Pullorum (S. Pullorum) have great damage to the poultry industry, but no perfect vaccine can protect them effectively until now. In this study, a recombinant-attenuated S. Pullorum strain secreting Newcastle disease virus hemagglutinin-neuraminidase (HN) protein, C79-13ΔcrpΔasd (pYA-HN), was constructed as a new bivalent vaccine candidate against Newcastle disease and S. Pullorum disease (PD) by the method of suicide plasmid pREasd-mediated bacteria homologous recombination...
October 13, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29032226/maternal-depressive-symptoms-linked-to-reduced-fecal-immunoglobulin-a-concentrations-in-infants
#2
Liane J Kang, Petya T Koleva, Catherine J Field, Gerald F Giesbrecht, Eytan Wine, Allan B Becker, Piushkumar J Mandhane, Stuart E Turvey, Padmaja Subbarao, Malcolm R Sears, James A Scott, Anita L Kozyrskyj
Secretory Immunoglobulin A (sIgA) plays a critical role to infant gut mucosal immunity. Delayed IgA production is associated with greater risk of allergic disease. Murine models of stressful events during pregnancy and infancy show alterations in gut immunity and microbial composition in offspring, but little is known about the stress-microbiome-immunity pathways in humans. We investigated differences in infant fecal sIgA concentrations according to the presence of maternal depressive symptoms during and after pregnancy...
October 11, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29023467/dietary-lactoferrin-supplementation-to-gilts-during-gestation-and-lactation-improves-pig-production-and-immunity
#3
Marefa Jahan, Susie Kracht, Yen Ho, Ziaul Haque, Birendra N Bhattachatyya, Peter C Wynn, Bing Wang
Lactoferrin (LF), a sialylated iron-binding glycoprotein, performs multiple beneficial functions including modulating immunity and improves neurodevelopment, health and growth performance. Maternal LF intervention for gilts (first parity sows) on the performance of gilts and their offspring remains unknown. In the current study gilts were fed with a commercial pig feed supplemented with 1g LF /day (treatment group) or 1g milk casein/day (control group) from day 1 post mating throughout pregnancy and lactation for about 135 days...
2017: PloS One
https://www.readbyqxmd.com/read/28984085/immunoprotective-effects-of-a-hemin-binding-peptide-derived-from-hemagglutinin-2-against-infection-with-porphyromonas-gingivalis
#4
Yongchao Zhu, Ting An, Ying Liu, Zilu Zhang, Qiubo Yang
The principal etiologic agent in periodontal disease, Porphyromonas gingivalis, generates cysteine proteases that bind heme with domains such as hemagglutinin-2 (HA2). High-affinity HA2-hemin binding supplies the porphyrin and ferric iron needed for growth and virulence. The DHYAVMISK peptide, recently identified at the hemin-binding site of HA2 inhibits hemin binding. We now evaluate the protective effect of vaccination with DGFPGDHYAVMISK (termed DK) against P. gingivalis using a rat infection model. Rats immunized with DK generated anti-peptide serum IgGs and salivary sIgAs (as measured by ELISA)...
October 6, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28984027/influence-of-a-preschool-preventive-dental-programme-on-caries-prevalence-oral-care-and-secretory-immunity-to-streptococcus-mutans-in-young-adults
#5
K L Aida, S de Paula Ramos, G F Seixas, A Bozza, R S Couto de Almeida, C C Dezan Garbelini
OBJECTIVE: To evaluate oral hygiene habits, decayed, missing and filled teeth (DMFT) and surfaces (DMFS), dental care, dietetic habits and anti-Streptococcus mutans salivary secretory Immunoglobulin A (SIgA) in young adults who attended a preventive programme during preschool age. MATERIAL AND METHODS: The study group (Baby Clinic) comprised 72 patients, aged 18-25 years, who had participated in the Baby Clinic preventive programme. The control group was age- and gender-matched...
October 6, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/28951299/hericium-erinaceus-polysaccharide-facilitates-restoration-of-injured-intestinal-mucosal-immunity-in-muscovy-duck-reovirus-infected-muscovy-ducklings
#6
Yijian Wu, Huihui Jiang, Erpeng Zhu, Jian Li, Quanxi Wang, Wuduo Zhou, Tao Qin, Xiaoping Wu, Baocheng Wu, Yifan Huang
To elucidate the effect of Hericium erinaceus polysaccharide (HEP) on the intestinal mucosal immunity in normal and Muscovy duck reovirus (MDRV)-infected Muscovy ducklings, 1-day-old healthy Muscovy ducklings were pretreated with 0.2g/L HEP and/or following by MDRV infection in this study, duodenal samples were respectively collected at 1, 3, 6, 10, 15 and 21day post-infection, tissue sections were prepared for observation of morphological structure and determination of intestinal parameters (villus height/crypt depth ratio, villus surface area) as well as counts of intraepithelial lymphocytes (IELs), goblet cells, mast cells...
September 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28947708/fitness-compensatory-mutations-facilitate-the-spread-of-drug-resistant-f15-lam4-kzn-and-f28-mycobacterium-tuberculosis-strains-in-kwazulu-natal-south-africa
#7
Charissa C Naidoo, Manormoney Pillay
While the acquisition of drug resistance is often accompanied by fitness costs, Mycobacterium tuberculosis has developed mechanisms to overcome these costs in the form of compensatory mutations. In an attempt to dissect strain-specific differences in biological fitness, 10 M. tuberculosis genomes, representing F15/LAM4/KZN, Beijing, F11 and F28 genotypes were sequenced on the Illumina MiSeq platform. Drug-susceptible F15/LAM4/KZN strains differed by 43 SNPs, demonstrating that heterogeneity exists even among closely-related strains...
September 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28946696/immunogenicity-of-egfp-marked-recombinant-lactobacillus-casei-against-transmissible-gastroenteritis-virus-and-porcine-epidemic-diarrhea-virus
#8
Meiling Yu, Li Wang, Sunting Ma, Xiaona Wang, Yusai Wang, Ya Xiao, Yanping Jiang, Xinyuan Qiao, Lijie Tang, Yigang Xu, Yijing Li
Porcine transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) are the causative agents of highly fatal acute diarrhea in pigs, resulting in enormous losses in the pig industry worldwide. To develop an effective bivalent oral vaccine against TGEV and PEDV infection, the D antigenic site of the TGEV spike (S) protein and the major antigen site (core neutralizing epitope-COE) of the PEDV S protein were used as immunogens, and the enhanced green fluorescent protein (eGFP) gene was used as a reporter to construct genetically engineered Lactobacillus casei rLpPG(F)-T7g10-eGFP-6D-COE...
September 25, 2017: Viruses
https://www.readbyqxmd.com/read/28945752/impact-of-enterobius-vermicularis-infection-and-mebendazole-treatment-on-intestinal-microbiota-and-host-immune-response
#9
Chin-An Yang, Chao Liang, Chia-Li Lin, Chiung-Tzu Hsiao, Ching-Tien Peng, Hung-Chih Lin, Jan-Gowth Chang
BACKGROUND: Previous studies on the association of enterobiasis and chronic inflammatory diseases have revealed contradictory results. The interaction of Enterobius vermicularis infection in particular with gut microbiota and induced immune responses has never been thoroughly examined. METHODOLOGY/FINDINGS: In order to answer the question of whether exposure to pinworm and mebendazole can shift the intestinal microbial composition and immune responses, we recruited 109 (30 pinworm-negative, 79 pinworm-infected) first and fourth grade primary school children in Taichung, Taiwan, for a gut microbiome study and an intestinal cytokine and SIgA analysis...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28944651/salivary-immunoglobulin-a-in-healthy-adolescent-females-effects-of-maximal-exercise-physical-activity-body-composition-and-diet
#10
Hermann J Engels, Bradley J Kendall, Mariane M Fahlman, Neha P Gothe, Kelsey C Bourbeau
BACKGROUND: The primary purpose of this study was to examine the effect of acute maximal exercise (VO2max test) on salivary immunoglobulin A (SIgA) responses in adolescent females. A secondary aim was to examine the relationship between resting SIgA levels and VO2max, physical activity, body composition, and diet. METHODS: Fifty healthy female adolescents completed a laboratory based VO2max test, assessment of body composition via hydrodensitometry, a validated physical activity questionnaire (PAQ- A), and a 3-day food diary...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28938780/effects-of-dietary-threonine-supplementation-on-intestinal-barrier-function-and-gut-microbiota-of-laying-hens
#11
X Y Dong, M M M Azzam, X T Zou
The effects of supplemental dietary threonine (Thr) on laying performance, expression of intestinal mucin 2 (MUC2) and secretory IgA (sIgA), and intestinal microbiota of laying hens fed a low CP diet were investigated. A total of 240 Lohmann Brown laying hens, 28 wk of age, was allocated to 3 dietary treatments, each of which included 5 replicates of 16 hens. Hens were fed a control diet (16% CP), a low CP diet (14% CP), or a low CP diet supplemented with 0.3% L-Thr for 12 weeks. Chemical analyses of the diets for Thr are 0...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28916315/the-effect-of-immune-modulation-of-streptococcus-constellatus-sc10-strain-upon-acinetobactor-baumannii-infection
#12
Abdullah A Alyousef, Israa M S Al-Kadmy
Acinetobacter baumannii is a tiny, plump and rod-shaped Gram-negative coccobacillus, notorious as an opportunistic pathogen, which is now being considered by CDC as a serious public health threat. Preventing colonization may be a better therapeutic choice using microbiota to protect against A. baumannii transmission. Human microbiota not only regulates immune homeostasis as well provides essential health benefits therefore discovering the interface due microbiota in host immune system will allow to recognise novel immuno- or microbe-based therapies...
October 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28904323/effects-of-bittern-water-on-cariogenic-bacteria-and-saliva-secretion
#13
Mariko Ohtsu, Muneaki Tamura, Hideto Sasaki, Shuichi Sato, Masatake Asano
The effects of bittern water (BW), obtained from the ocean floor, on cariogenic bacteria and saliva secretion were examined. Streptococcus mutans was mixed with BW for 1, 3, 5, 10, and 20 min to explore the bactericidal effects of BW against cariogenic bacteria. Bacterial viability was calculated by counting the number of colony-forming units on Brain Heart Infusion agar plates. The results indicated a bacterial viability of more than 35% even after 20 min of incubation. Subsequently, the effects of BW on saliva secretion and the salivary concentration of secretory IgA (sIgA) were examined...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28892827/role-of-microbiota-in-strengthening-ocular-mucosal-barrier-function-through-secretory-iga
#14
Abirami Kugadas, Quentin Wright, Jennifer Geddes-McAlister, Mihaela Gadjeva
Purpose: The purpose of this study was to evaluate mechanisms controlling secretory IgA (SIgA) production, thereby ensuring maintenance of ocular surface health. Methods: To determine whether the presence of specific gut commensal species regulates SIgA levels and IgA transcripts in the eye-associated lymphoid tissues (EALT), specific-pathogen-free (SPF) Swiss Webster (SW) mice were treated with antibiotic cocktails, germ-free (GF) SW mice were reconstituted with diverse commensal gut microbiota, or monocolonized with gut-specific commensals...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28872424/intensified-training-period-increases-salivary-iga-responses-but-does-not-affect-the-severity-of-upper-respiratory-tract-infection-symptoms-in-prepuberal-rhythmic-gymnasts
#15
Kizzy Antualpa, Marcelo Saldanha Aoki, Alexandre Moreira
This study examined the effect of a 4-week intensified training period (IT), followed by a 2-week tapering period (TP), on salivary immunoglobulin A (SIgA), salivary cortisol (CORT) and the severity of upper respiratory tract infection (URTI) symptoms in 23 rhythmic gymnasts (12.1±2.6 yrs; 143.9±13.7 cm; 37.2±9.4 kg). Saliva sampling was conducted at pre- and post-IT, and post-TP (analyzed using ELISA). The WURSS-21 questionnaire was completed daily to analyze the severity of URTI symptoms. The session-RPE was used to determine the internal training load and the acute:chronic workload ratio (ACW)...
September 5, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28843478/chronic-alcohol-consumption-regulates-the-expression-of-poly-immunoglobulin-receptor-pigr-and-secretory-iga-in-the-gut
#16
María C López
The effect of ethanol (EtOH) on the gut immune system was analyzed using an experimental model previously described, where EtOH was provided ad libitum in the drinking water in a 20% w/v concentration for up to 12weeks. Dendritic cells, T cells and macrophages were analyzed in Peyer's patches and the small intestines using flow cytometry. Cytokine and immunoglobulin levels were analyzed in sera, feces, and homogenates from small and large intestines and lungs. Decreases in the proportion of T cells and alterations in dendritic cells and macrophages were observed after EtOH treatment...
October 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28825870/intranasal-immunization-with-a-single-dose-of-the-fusion-protein-formulated-with-a-combination-adjuvant-induces-long-term-protective-immunity-against-respiratory-syncytial-virus
#17
R Garg, L Latimer, V Gerdts, A Potter, S van Drunen Littel-van den Hurk
Respiratory syncytial virus (RSV) is the most common cause of respiratory tract infections in both children and elderly people. In this study we evaluated the short- and long-term protective efficacy of a single intranasal (IN) immunization with a RSV vaccine formulation consisting of a codon-optimized fusion (F) protein formulated with poly(I:C), an innate defense regulator peptide and a polyphosphazene (ΔF/TriAdj). This vaccine induced strong systemic and local immune responses, including RSV F-specific IgG1 and IgG2a, SIgA and virus neutralizing antibodies in mice...
August 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28819629/mixed-lactobacillus-plantarum-strains-inhibit-staphylococcus-aureus-induced-inflammation-and-ameliorate-intestinal-microflora-in-mice
#18
Dayong Ren, Shengjie Gong, Jingyan Shu, Jianwei Zhu, Fengjun Rong, Zhenye Zhang, Di Wang, Liangfeng Gao, Tianming Qu, Hongyan Liu, Ping Chen
Objective. Staphylococcus aureus is an important pathogen that causes intestinal infection. We examined the immunomodulatory function of single and mixed Lactobacillus plantarum strains, as well as their impacts on the structure of the microbiome in mice infected with Staphylococcus aureus. The experiment was divided into three groups: protection, treatment, and control. Serum IFN-γ and IL-4 levels, as well as intestinal sIgA levels, were measured during and 1 week after infection with Staphylococcus aureus with and without Lactobacillus plantarum treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28811748/salivary-diagnostic-markers-in-males-and-females-during-rest-and-exercise
#19
Kay Rutherfurd-Markwick, Carlene Starck, Deborah K Dulson, Ajmol Ali
BACKGROUND: Saliva is a useful diagnostic tool for analysis in sports, exercise and nutrition research, as collection is easy and non-invasive and it contains a large number of analytes affected by a range of physiological and pathological stressors and conditions. This study examined key salivary electrolytes and stress and immune markers in males and females at rest and during exercise. METHODS: Unstimulated whole saliva from 20 healthy, recreationally active participants (8 males and 12 females) was analysed for flow rate, osmolality, sodium (Na(+)), potassium (K(+)), chloride (Cl(-)), secretory immunoglobulin A (SIgA), α-amylase activity and cortisol during both rest and moderate intensity (70% peak power) cycling exercise in a randomised crossover design...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28811215/molecular-mechanisms-underlying-protection-against-h9n2-influenza-virus-challenge-in-mice-by-recombinant-lactobacillus-plantarum-with-surface-displayed-ha2-ltb
#20
Yanlong Jiang, Guilian Yang, Qi Wang, Zhannan Wang, Wentao Yang, Wei Gu, Chunwei Shi, Jianzhong Wang, Haibin Huang, Chunfeng Wang
It has been considered that the Avian influenza virus (AIV) causes severe threats to poultry industry. In this study, we constructed a series of recombinant Lactobacillus plantarum (L. plantarum) with surface displayed hemagglutinin subunit 2 (HA2) alone or together with heat-labile toxin B subunit (LTB) from enterotoxigenic Escherichia coli. Balb/c mice were used as model to evaluate the protective effects of recombinant L. plantarum strains against H9N2 subtype challenge. The results showed that the presence of LTB significantly increased the percentages of CD3(+)CD4(+)IL-4(+), CD3(+)CD4(+)IFN-γ(+) and CD3(+)CD4(+)IL-17(+) T cells, as well as CD3(+)CD8(+)IFN-γ(+) T cells in spleen and MLNs determined by Fluorescence-Activated Cell Sorting assay...
August 12, 2017: Journal of Biotechnology
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