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https://www.readbyqxmd.com/read/29223454/preparation-characterization-and-immunological-evaluation-of-alginate-nanoparticles-loaded-with-whole-inactivated-influenza-virus-dry-powder-formulation-for-nasal-immunization-in-rabbits
#1
Solmaz Dehghan, Masoumeh Tavassoti Kheiri, Khalil Abnous, Maryam Eskandari, Mohsen Tafaghodi
It has become important to explore more efficient and feasible influenza vaccines, since epidemics of influenza virus cause hundreds of thousands of deaths all around the world. Improving immunogenicity of parentral influenza vaccines has given rise to mucosal delivery routes. In this study, alginate nanoparticles (NPs) were efficiently synthetized by ionic gelation method and influenza virus and CpG ODN or Quillaja Saponin (QS) adjuvants were actively incorporated into alginate NPs. The prepared particles were evaluated for both humoral and cellular immune responses in rabbits' nostrils...
December 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29216826/6s-rna-plays-a-role-in-recovery-from-nitrogen-depletion-in-synechocystis-sp-pcc-6803
#2
Beate Heilmann, Kaisa Hakkila, Jens Georg, Taina Tyystjärvi, Wolfgang R Hess, Ilka M Axmann, Dennis Dienst
BACKGROUND: The 6S RNA is a global transcriptional riboregulator, which is exceptionally widespread among most bacterial phyla. While its role is well-characterized in some heterotrophic bacteria, we subjected a cyanobacterial homolog to functional analysis, thereby extending the scope of 6S RNA action to the special challenges of photoautotrophic lifestyles. RESULTS: Physiological characterization of a 6S RNA deletion strain (ΔssaA) demonstrates a delay in the recovery from nitrogen starvation...
December 8, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29211897/effect-of-yeast-cell-wall-on-the-growth-performance-and-gut-health-of-broilers-challenged-with-aflatoxin-b1-and-necrotic-enteritis
#3
N Liu, J Q Wang, S C Jia, Y K Chen, J P Wang
This study aimed to investigate the effect of yeast cell walls (YCW) on the growth performance, visceral lesions, intestinal integrity, enterotoxicity, and bacteria of broilers challenged with aflatoxin B1 (AF) and necrotic enteritis (NE) from 1 to 21 d of age. A total of 576 one-day-old broilers were assigned to a 2 × 2 × 2 design for diets containing AFB1 (0 or 40 μg/kg), NE (challenged or unchallenged), or YCW (0 or 500 mg/kg). The main effect analysis showed that AF depressed (P < 0.01) average daily feed intake (ADFI), average daily body weight gain (ADG), the mRNA profiles of polymeric Ig receptor (pIgR), claudin-1, and occludin, but increased (P < 0...
December 2, 2017: Poultry Science
https://www.readbyqxmd.com/read/29182422/salivary-biomarkers-and-training-load-during-training-and-competition-in-paralympic-swimmers
#4
Ciara Sinnott-O'Connor, Tom Comyns, Alan M Nevill, Giles Warrington
PURPOSE: Stress responses in athletes can be attributed to training and also competition, where increased physiological and psychological stress may negatively impact on performance and recovery. The aim of this study was to examine the relationship between training load and salivary biomarkers IgA, alpha-amylase (AA) and cortisol across a 16-week preparation phase and 10-day competition phase in Paralympic swimmers. METHODS: Four Paralympic swimmers provided bi-weekly saliva samples during three training phases - 1) normal training, 2) intensified training and 3) taper as well as daily saliva samples in the 10 day Paralympic competition (2016 Paralympic Games)...
November 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29181304/dna-vaccine-expressing-herpes-simplex-virus-1-glycoprotein-c-and-d-protects-mice-against-herpes-simplex-keratitis
#5
Li-Li Dong, Ru Tang, Yu-Jia Zhai, Tejsu Malla, Kai Hu
AIM: To investigate whether DNA vaccine encoding herpes simplex virus 1 (HSV-1) glycoprotein C (gC) and glycoprotein D (gD) will achieve better protective effect against herpes simplex keratitis (HSK) than DNA vaccine encoding gD alone. METHODS: DNA vaccine expressing gD or gC combined gD (gD.gC) were constructed and carried by chitosan nanoparticle. The expression of fusion protein gD and gC were detected in DNA/nanoparticle transfected 293T cells by Western-blot...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29178509/oral-immunization-with-a-lactobacillus-casei-based-anti-porcine-epidemic-diarrhea-virus-pedv-vaccine-expressing-microfold-cell-targeting-peptide-co1-fused-with-the-coe-antigen-of-pedv
#6
Xiaona Wang, Li Wang, Dianzhong Zheng, Su Chen, Wen Shi, Xinyuan Qiao, Yanping Jiang, Lijie Tang, Yigang Xu, Yijing Li
AIMS: The aims of this study were to develop an effective M cell-targeting oral vaccine, involving Lactobacillus casei to deliver the PEDV core neutralizing epitope (COE) antigen conjugated with M cell-targeting peptide Co1 as an adjuvant, against PEDV infection. METHODS AND RESULTS: Genetically engineered Lactobacillus casei 393 (L393) strains expressing PEDV core neutralizing epitope (COE) antigen only (pPG-COE/L393) or fused-expressing COE and M cell-targeting peptide Co1 (pPG-COE-Co1/L393) were constructed and the immunogenicity upon administration as an oral vaccine was evaluated...
November 27, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29172532/enhancing-mucosal-immune-response-of-newcastle-disease-virus-dna-vaccine-using-n-2-hydroxypropyl-trimethyl-ammonium-chloride-chitosan-and-n-o-carboxymethyl-chitosan-nanoparticles-as-delivery-carrier
#7
Kai Zhao, Jinyu Han, Yang Zhang, Lin Wei, Shuang Yu, Xiaohua Wang, Zheng Jin, Yun-Feng Wang
Because mucosal sites are the entry ports of pathogens, immunization via mucosal routes can extremely enhance the immunity. To elevate the potential of N-2-hydroxypropyl trimethyl ammonium chloride chitosan (N-2-HACC) and N,O-carboxymethyl chitosan (CMC) nanoparticles as a mucosal immune delivery carrier for DNA vaccines, we prepared the NDV F gene plasmid DNA with C3d6 molecular adjuvant (pVAX I -F(o)-C3d6) encapsulated in the N-2-HACC-CMC nanoparticles (N-2-HACC-CMC/pFDNA-C3d6 NPs). The N-2-HACC-CMC/pFDNA-C3d6 NPs had regular spherical morphology and low toxicity with a mean diameter of 309...
November 27, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29171012/children-s-anxiety-symptoms-and-salivary-immunoglobulin-a-a-mutual-regulatory-system
#8
Denise Ma, Lisa A Serbin, Dale M Stack
Anxiety can impact the immune system resulting in negative health outcomes. Salivary immunoglobulin A (sIgA) is a first line of defense against foreign antigens, with lowered levels indicative of weakened mucosal immunity. Little is known about how anxiety symptoms affect the diurnal rhythm of sIgA secretion, or the longitudinal transactional sequence between the two in children and adolescents. The goals of the two studies were to: (i) explore the concurrent associations between self-reported anxiety symptoms and diurnal variations of sIgA across the day using repeated daily samples of sIgA; and (ii) examine transactional relations between children's anxiety and aggregated total amount of sIgA levels across successive periods from middle childhood (Wave 1; ages 9-12) to early adolescence (Wave 2; ages 12-15), and from early to mid- adolescence (Wave 3; ages 15-18)...
November 24, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/29142827/overexpression-of-the-primary-sigma-factor-gene-siga-improved-carotenoid-production-by-corynebacterium-glutamicum-application-to-production-of-%C3%AE-carotene-and-the-non-native-linear-c50-carotenoid-bisanhydrobacterioruberin
#9
Hironori Taniguchi, Nadja A Henke, Sabine A E Heider, Volker F Wendisch
Corynebacterium glutamicum shows yellow pigmentation due to biosynthesis of the C50 carotenoid decaprenoxanthin and its glycosides. This bacterium has been engineered for production of various non-native cyclic C40 and C50 carotenoids such as β-carotene, astaxanthin or sarcinaxanthin. In this study, the effect of modulating gene expression more broadly by overexpression of sigma factor genes on carotenoid production by C. glutamicum was characterized. Overexpression of the primary sigma factor gene sigA improved lycopene production by recombinant C...
June 2017: Metabolic Engineering Communications
https://www.readbyqxmd.com/read/29131241/insulin-like-growth-factor-i-reduces-the-occurrence-of-necrotizing-enterocolitis-by-reducing-inflammatory-response-and-protecting-intestinal-mucosal-barrier-in-neonatal-rats-model
#10
F Tian, G-R Liu, N Li, G Yuan
OBJECTIVE: To observe the effect of enteral supplement of insulin-like growth factor I (IGF-1) on dynamic changes of TLR4, NF-κB, IL-6, SIgA and MUC2 in intestinal tissues of neonatal rats, and to investigate the protective effects and possible mechanisms of IGF-1 on necrotizing enterocolitis (NEC). MATERIALS AND METHODS: Specific pathogen free (SPF) neonatal Sprague Dawley (SD) rats aged 3 days old were randomly divided into 3 groups, namely, normal control group, NEC model group and IGF-1 intervention group...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29121039/the-prevalence-and-determinants-of-multimorbidity-in-hospitalized-patients-with-heart-failure
#11
Olga Siga, Barbara Wizner, Karolina Piotrowicz, Małgorzata Fedyk-Łukasik, Tomasz Grodzicki
OBJECTIVE: The aim of this study was to assess the prevalence of multimorbidity and co-existed diseases in hospitalized patients with heart failure (HF) in relation to age and gender. METHODS: The nationwide cross-sectional survey had been conducted in Poland (April-November 2013), in 260 randomly selected hospital wards. A trained nurse contacted with one physician, drawn from the list of all doctors working in the selected hospital's wards, who completed the study questionnaires regarding to clinical characteristics of the last five HF patients, who were discharged from an internal or cardiology ward...
2017: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/29109718/siga-tgf-%C3%AE-1-il-10-and-tnf%C3%AE-in-colostrum-are-associated-with-infant-group-b-streptococcus-colonization
#12
Kirsty Le Doare, Katie Bellis, Amadou Faal, Jessica Birt, Daniel Munblit, Holly Humphries, Stephen Taylor, Fiona Warburton, Paul T Heath, Beate Kampmann, Andrew Gorringe
Background: Group B Streptococcus (GBS) is a major cause of mortality and morbidity in infants and is associated with transmission from a colonized mother at birth and via infected breastmilk. Although maternal/infant colonization with GBS is common, the majority of infants exposed to GBS remain unaffected. The association between breastmilk immune factors and infant colonization and disease prevention has not been elucidated. Objectives: We have investigated the association between SIgA and cytokines in breastmilk and infant GBS colonization and clearance...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29108012/oral-immunization-of-a-non-recombinant-lactococcus-lactis-surface-displaying-influenza-hemagglutinin-1-ha1-induces-mucosal-immunity-in-mice
#13
Pui-Fong Jee, Vunjia Tiong, Meng-Hooi Shu, Jing-Jing Khoo, Won Fen Wong, Raha Abdul Rahim, Sazaly AbuBakar, Li-Yen Chang
Mucosal immunization of influenza vaccine is potentially an effective approach for the prevention and control of influenza. The objective of the present study was to evaluate the ability of oral immunization with a non-recombinant Lactococcus lactis displaying HA1/L/AcmA recombinant protein, LL-HA1/L/AcmA, to induce mucosal immune responses and to accord protection against influenza virus infection in mice. The LL-HA1/L/AcmA was orally administered into mice and the immune response was evaluated. Mice immunized with LL-HA1/L/AcmA developed detectable specific sIgA in faecal extract, small intestine wash, BAL fluid and nasal fluid...
2017: PloS One
https://www.readbyqxmd.com/read/29090450/effects-of-environmental-tobacco-smoke-on-the-oral-health-of-preschool-children
#14
N N B Hasmun, B K Drummond, T Milne, M P Cullinan, A M Meldrum, D Coates
AIMS: This study investigated the association between the prevalence of oral health problems (caries, gingivitis, mucosal pigmentation and enamel defects in one to 5 year-old children exposed and not exposed to environmental tobacco smoke before and/or after birth. Exposure to environmental tobacco smoke (ETS) in childhood may have significant health effects. METHODS: A structured questionnaire was used to collect data on a child's current and previous illnesses, oral health behaviours, dietary habits, parental smoking behaviours and parents' dental history...
October 31, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29090342/recombinant-lactobacillus-plantarum-expressing-ha2-antigen-elicits-protective-immunity-against-h9n2-avian-influenza-virus-in-chickens
#15
Wen-Tao Yang, Gui-Lian Yang, Xin Yang, Seria-Masole Shonyela, Liang Zhao, Yan-Long Jiang, Hai-Bin Huang, Chun-Wei Shi, Jian-Zhong Wang, Guan Wang, Jin-Hui Zhao, Chun-Feng Wang
Low pathogenic H9N2 subtype avian influenza virus (AIV) can lead to moderate respiratory symptoms and low egg production rates in poultry. Due to its immunologic suppression, other various infectious pathogens give rise to the co-infection of hosts, causing heavy economic losses in the commercial poultry industry in both China and worldwide. Therefore, it is time to explore a novel, safe, and effective vaccine. We have already made use of the surface of Lactobacillus plantarum to display AIV HA2 (NC8-pSIP409-pgsA'-HA2), which demonstrated that it has a good immunogenicity...
December 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29084143/red-wine-resveratrol-and-atrial-fibrillation
#16
REVIEW
Laura Siga Stephan, Eduardo Dytz Almeida, Melissa Medeiros Markoski, Juliano Garavaglia, Aline Marcadenti
Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with increased risk for cardiovascular disease and overall mortality. Excessive alcohol intake is a well-known risk factor for AF, but this correlation is less clear with light and moderate drinking. Besides, low doses of red wine may acutely prolong repolarization and slow cardiac conduction. Resveratrol, a bioactive polyphenol found in grapes and red wine, has been linked to antiarrhythmic properties and may act as an inhibitor of both intracellular calcium release and pathological signaling cascades in AF, eliminating calcium overload and preserving the cardiomyocyte contractile function...
October 30, 2017: Nutrients
https://www.readbyqxmd.com/read/29082265/vaccinomics-approach-for-designing-potential-peptide-vaccine-by-targeting-shigella-spp-serine-protease-autotransporter-subfamily-protein-siga
#17
Arafat Rahman Oany, Tahmina Pervin, Mamun Mia, Motaher Hossain, Mohammad Shahnaij, Shahin Mahmud, K M Kaderi Kibria
Shigellosis, a bacillary dysentery, is closely associated with diarrhoea in human and causes infection of 165 million people worldwide per year. Casein-degrading serine protease autotransporter of enterobacteriaceae (SPATE) subfamily protein SigA, an outer membrane protein, exerts both cytopathic and enterotoxic effects especially cytopathic to human epithelial cell type-2 (HEp-2) and is shown to be highly immunogenic. In the present study, we have tried to impose the vaccinomics approach for designing a common peptide vaccine candidate against the immunogenic SigA of Shigella spp...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29077887/effects-of-dietary-supplementation-with-enzymatically-treated-artemisia-annua-on-growth-performance-intestinal-morphology-digestive-enzyme-activities-immunity-and-antioxidant-capacity-of-heat-stressed-broilers
#18
Z H Song, K Cheng, X C Zheng, H Ahmad, L L Zhang, T Wang
The gastrointestinal tract is considered as one of the main target organs affected by heat stress. Phytogenic feed additives containing phenolics and flavonoids can improve the resistance of broilers to heat stress. This study was conducted to investigate the effects of dietary supplementation with enzymatically treated Artemisia annua (EA) on growth performance, intestinal morphology, digestive enzyme activities, immunity and antioxidant capacity of broilers challenged with heat stress. One hundred and forty-four 21-day-old male Arbor Acres broilers were randomly distributed into 3 treatments: 1) non-challenged control (CON); 2) heat-stress-challenged control (HS); and 3) heat-stress-challenged group + 1 g EA/kg diet (HS-EA)...
October 25, 2017: Poultry Science
https://www.readbyqxmd.com/read/29075899/immunoglobulin-a-and-liver-diseases
#19
REVIEW
Tatsuo Inamine, Bernd Schnabl
Immunoglobulin A (IgA) is a major immunoglobulin isotype in the gut and plays a role in maintenance of gut homeostasis. Secretory IgA (SIgA) has multiple functions in the gut, such as to regulate microbiota composition, to protect intestinal epithelium from pathogenic microorganisms, and to help for immune-system development. The liver is the front-line organ that receives gut-derived products through the portal vein, implying that the liver could be severely affected by a disrupted intestinal homeostasis. Indeed, some liver diseases like alcoholic liver disease are associated with an altered composition of gut microbiota and increased blood endotoxin levels...
October 26, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29068402/oral-delivery-of-probiotics-expressing-dendritic-cell-targeting-peptide-fused-with-porcine-epidemic-diarrhea-virus-coe-antigen-a-promising-vaccine-strategy-against-pedv
#20
Xiaona Wang, Li Wang, Xuewei Huang, Sunting Ma, Meiling Yu, Wen Shi, Xinyuan Qiao, Lijie Tang, Yigang Xu, Yijing Li
Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, is the causative agent of porcine epidemic diarrhea (PED) that damages intestinal epithelial cells and results in severe diarrhea and dehydration in neonatal suckling pigs with up to 100% mortality. The oral vaccine route is reported as a promising approach for inducing protective immunity against PEDV invasion. Furthermore, dendritic cells (DCs), professional antigen-presenting cells, link humoral and cellular immune responses for homeostasis of the intestinal immune environment...
October 25, 2017: Viruses
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