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https://www.readbyqxmd.com/read/28319123/saccharomyces-boulardii-and-bacillus-subtilis-b10-modulate-tlrs-and-cytokines-expression-patterns-in-jejunum-and-ileum-of-broilers
#1
Imran Rashid Rajput, Huang Ying, Sun Yajing, Muhammad Asif Arain, Li Weifen, Li Ping, Dost Muhammad Bloch, Liu Wenhua
The present study was designed to evaluate the effects of Saccharomyces boulardii (Sb) and Bacillus subtilis B10 (Bs) on intestinal epithelial Toll like receptors (TLR), and Cytokine expression response to understand the intestinal epithelial innate immune mechanism in broilers. A total of 300 birds (Sanhuang broilers) were allotted into three groups (n = 100) and each divided into five replications (n = 20). Control group (Ctr) birds were fed basal diet, broilers in experimental groups received (1×108cfu/kg feed) Sb and Bs respectively in addition to basal diet for 72 days...
2017: PloS One
https://www.readbyqxmd.com/read/28299479/l-glutamine-and-l-arginine-protect-against-enterotoxigenic-escherichia-coli-infection-via-intestinal-innate-immunity-in-mice
#2
Gang Liu, Wenkai Ren, Jun Fang, Chien-An Andy Hu, Guiping Guan, Naif Abdullah Al-Dhabi, Jie Yin, Veeramuthu Duraipandiyan, Shuai Chen, Yuanyi Peng, Yulong Yin
Dietary glutamine (Gln) or arginine (Arg) supplementation is beneficial for intestinal health; however, whether Gln or Arg may confer protection against Enterotoxigenic Escherichia coli (ETEC) infection is not known. To address this, we used an ETEC-infected murine model to investigate the protective effects of Gln and Arg. Experimentally, we pre-treated mice with designed diet of Gln or Arg supplementation prior to the oral ETEC infection and then assessed mouse mortality and intestinal bacterial burden. We also determined the markers of intestinal innate immunity in treated mice, including secretory IgA response (SIgA), mucins from goblet cells, as well as antimicrobial peptides from Paneth cells...
March 15, 2017: Amino Acids
https://www.readbyqxmd.com/read/28266682/immunomodulatory-effects-of-hericium-erinaceus-derived-polysaccharides-are-mediated-by-intestinal-immunology
#3
Xiaotong Sheng, Jingmin Yan, Yue Meng, Yuying Kang, Zhen Han, Guihua Tai, Yifa Zhou, Hairong Cheng
This study was aimed at investigating the immunomodulating activity of Hericium erinaceus polysaccharide (HEP) in mice, by assessing splenic lymphocyte proliferation (cell-mediated immunity), serum hemolysin levels (humoral immunity), phagocytic capacity of peritoneal cavity phagocytes (macrophage phagocytosis), and NK cell activity. ELISA of immunoglobulin A (SIgA) in the lamina propria, and western blotting of small intestinal proteins were also performed to gain insight into the mechanism by which HEP affects the intestinal immune system...
March 7, 2017: Food & Function
https://www.readbyqxmd.com/read/28264682/an-engineered-food-grade-lactococcus-lactis-strain-for-production-and-delivery-of-heat-labile-enterotoxin-b-subunit-to-mucosal-sites
#4
Nan Sun, Rongguang Zhang, Guangcai Duan, Xiaoyan Peng, Chen Wang, Qingtang Fan, Shuaiyin Chen, Yuanlin Xi
BACKGROUND: Recent researches have been focusing on mucosal immune adjuvants, which play the key roles in mucosal immunization and have become the limitation for non-injected vaccine development. Escherichia coli heat-labile enterotoxin B subunit (LTB) was regarded as a promising mucosal adjuvant for its nontoxicity and potent activity. LTB preparation issues have always been recurring, in part owing to that the recombinant LTB expressed by E. coli does not act as its native form. RESULTS: We constructed an engineered Lactococcus lactis strain using a food-grade expression system...
March 6, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28263433/salivary-secretory-iga-concentration-and-dental-caries-in-children-with-down-syndrome
#5
Lina N Hashizume, Carolina Schwertner, Maurício José Santos Moreira, Adriana Simon Coitinho, Lavinia Schuler Faccini
PURPOSE: To evaluate the relationship between salivary secretory immunoglobulin A (sIgA) concentration and dental caries in children with Down syndrome (DS) and compare it with findings in non-DS children. METHODS: The sample comprised 61 DS children and 52 non-DS children, aged 6 to 14 years. Caries experience, plaque index (PI), and gingival bleeding index (GBI) were recorded. Saliva samples were collected from all children. Total salivary sIgA concentrations were determined using an enzymatic assay method...
March 6, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28254427/distribution-of-serine-protease-autotransporters-of-enterobacteriaceae-in-typical-and-atypical-enteroaggregative-escherichia-coli
#6
Fernanda B Andrade, Afonso G Abreu, Kamila O Nunes, Tânia A T Gomes, Roxane M F Piazza, Waldir P Elias
Enteroaggregative Escherichia coli (EAEC) is an agent of acute and persistent diarrhea worldwide, categorized in typical or atypical subgroups. Some EAEC virulence factors are members of the serine protease autotransporters of Enterobacteriaceae (SPATE). The presence of SPATE-encoding genes of different E. coli pathotypes was searched in a large collection of EAEC strains, and a possible association between SPATEs and E. coli phylogroups was investigated. Among 108 typical and 85 atypical EAEC, pic was the most prevalent gene, detected in 47...
February 28, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28250847/oral-administration-of-clostridium-butyricum-cgmcc0313-1-inhibits-%C3%AE-lactoglobulin-induced-intestinal-anaphylaxis-in-a-mouse-model-of-food-allergy
#7
Juan Zhang, Hui Su, Qiuhong Li, Haixia Wu, Mengyun Liu, Jianqiong Huang, Minghua Zeng, Yuejie Zheng, Xin Sun
BACKGROUND: Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of beneficial bacteria for allergic diseases recently. This study aimed at exploring whether Clostridium butyricum CGMCC0313-1 (C. butyricum) can reduce β-lactoglobulin(BLG)-induced intestinal anaphylaxis in a murine model of food allergy. METHODS: The preventive and therapeutic effects of oral C...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28245626/bifidobacterium-bifidum-olb6378-simultaneously-enhances-systemic-and-mucosal-humoral-immunity-in-low-birth-weight-infants-a-non-randomized-study
#8
Katsunori Tanaka, Takamitsu Tsukahara, Takahide Yanagi, Sayuri Nakahara, Ouki Furukawa, Hidemi Tsutsui, Shigeki Koshida
Probiotic supplementation has been part of the discussion on methods to enhance humoral immunity. Administration of Bifidobacterium bifidum OLB6378 (OLB6378) reduced the incidence of late-onset sepsis in infants. In this non-randomized study, we aimed to determine the effect of administration of live OLB6378 on infants' humoral immunity. Secondly, we tried to elucidate whether similar effects would be observed with administration of non-live OLB6378. Low birth weight (LBW) infants weighing 1500-2500 g were divided into three groups: Group N (no intervention), Group L (administered live OLB6378 concentrate), and Group H (administered non-live OLB6378 concentrate)...
February 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28244557/goal-setting-instruments-in-geriatric-rehabilitation-a-systematic-review
#9
R van Seben, L Reichardt, S Smorenburg, B Buurman
This systematic review summarizes the psychometric properties of goal-setting instruments that are applied within geriatric rehabilitation. PubMed Medline and Embase were systematically searched for eligible articles. Studies were included if they were conducted in a somatic or neurological rehabilitation setting, included patients aged ≥55 years and provided data on instruments' psychometric properties (validity, reliability, responsiveness), utility and/or feasibility. Eleven studies were included. Seven studies, all conducted by one research group, evaluated Goal-Attainment Scaling (GAS), two studies assessed the Canadian Occupational Performance Measure (COPM) and one study the Self-Identified Goals Assessment (SIGA), which is based on the COPM...
2017: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/28239378/enterococcus-durans-ep1-a-promising-anti-inflammatory-probiotic-able-to-stimulate-siga-and-to-increase-faecalibacterium-prausnitzii-abundance
#10
Paula Carasi, Silvia María Racedo, Claudine Jacquot, Anne Marie Elie, María de Los Ángeles Serradell, María C Urdaci
Enterococcus species, principally Enterococcus faecium are used as probiotics since a long time with preference in animal applications but safety considerations were updated and also new uses as probiotics can be envisaged. Fifteen Enterococcus strains isolated from different foods were identified and analyzed for virulence factors and antibiotic resistance. Three Enterococcus durans strains were selected to study their immunomodulatory properties on PBMC and Caco2 cells. Two strains presented a profile toward a mild inflammatory Th1 response considering TNF-α/IL-10 and IL-1β/IL-10 cytokines ratios...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28220870/long-term-use-of-ceftriaxone-sodium-induced-changes-in-gut-microbiota-and-immune-system
#11
Yanjie Guo, Xuefei Yang, Yane Qi, Shu Wen, Yinhui Liu, Shaoying Tang, Rongsheng Huang, Li Tang
Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities. Previous studies have all focused on the effects of short term use of antibiotics. Here, we focus on the effects of long term use of antibiotic on gut microbiota and immunity. BALB/c mice received saline or different doses of ceftriaxone sodium (100, 200 and 400 mg/mL) via daily gavage for 150 days. Alterations of fecal microbiota, small intestine histopathology, body weight, spleen index, serum IgG, mucus SIgA, IFN-γ/IL-4 ratio, CD4/CD8 ratio and CD4(+)CD25(+) cells were evaluated...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194462/designing-an-efficient-multi-epitope-oral-vaccine-against-helicobacter-pylori-using-immunoinformatics-and-structural-vaccinology-approaches
#12
Navid Nezafat, Mahboobeh Eslami, Manica Negahdaripour, Mohammad Reza Rahbar, Younes Ghasemi
Helicobacter pylori is the cunning bacterium that can live in the stomachs of many people without any symptoms, but gradually can lead to gastric cancer. Due to various obstacles, which are related to anti-H. pylori antibiotic therapy, recently developing an anti-H. pylori vaccine has attracted more attention. In this study, different immunoinformatics and computational vaccinology approaches were employed to design an efficient multi-epitope oral vaccine against H. pylori. Our multi-epitope vaccine is composed of heat labile enterotoxin IIc B (LT-IIc) that is used as a mucosal adjuvant to enhance vaccine immunogenicity for oral immunization, cartilage oligomeric matrix protein (COMP) to increase vaccine stability in acidic pH of gut, one experimentally protective antigen, OipA, and two hypothetical protective antigens, HP0487 and HP0906, and "CTGKSC" peptide motif that target epithelial microfold cells (M cells) to enhance vaccine uptake from the gut barrier...
February 14, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28183153/effects-of-armillariella-tabescens-mycelia-on-the-growth-performance-and-intestinal-immune-response-and-microflora-of-early-weaned-pigs
#13
Wen-Bin Chen, Mao-Ji Cheng, Yun-Bo Tian, Qin-Hua Wang, Bing Wang, Mei-Jun Li, Re-Jun Fang
This study was performed to evaluate effects of Armillariella tabescens (A. tabescens) on the growth performance and intestinal immune response and microflora in early-weaned pigs when used as feed additive. A. tabescens mycelia were added to basal diets at concentrations of 0%, 0.1%, 0.3% or 0.9% (w/w). A total of 144 commercial cross-bred piglets were randomly allocated to one of these four diets and fed for 30 days. The growth performance of early-weaned piglets displayed improvement with diets containing 0...
February 9, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28151031/modulation-by-bovine-lactoferrin-of-parameters-associated-with-the-iga-response-in-the-proximal-and-distal-small-intestine-of-balb-c-mice
#14
Marycarmen Godínez-Victoria, Teresita Rocío Cruz-Hernández, Humberto Reyna-Garfias, Reyna Elizabeth Barbosa-Cabrera, Maria Elisa Drago-Serrano, María Cristina Sánchez-Gómez, Rafael Campos-Rodríguez
BACKGROUND: Secretory IgA (SIgA) and the polymeric immunoglobulin receptor (pIgR) have a pivotal role in gut homeostasis. Bovine lactoferrin (bLf) has been shown to modulate intestinal immunity and endogenous corticosterone. Considering the regionalization of the intestinal immune response, the aim of this work was to compare the impact of bLf on the IgA response in the proximal versus distal small intestine under physiological conditions. METHODS: Groups of healthy male BALB/c mice were orally treated with one daily dose of bLf (50, 500, or 5000 μg) or untreated (control) for 7 d, and then sacrificed...
April 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28149416/monitoring-salivary-immunoglobulin-a-responses-to-official-and-simulated-matches-in-elite-young-soccer-players
#15
Camila G Freitas, Marcelo S Aoki, Ademir F S Arruda, Clóvis Franciscon, Alexandre Moreira
The purpose of the present study was to examine SIgA responses (concentration [SIgAabs] and a secretion rate [SIgArate]) to official and simulated competitive matches in young soccer players. The sample was composed of 26 male soccer players (age 15.6 ± 1.1 yrs, stature 177.0 ± 6.1 cm, body mass 70.5 ± 5.7 kg). Four soccer matches (two simulated matches [SM] and two official matches [OM]) were conducted. The matches consisted of two halves of 35 min with a 10 min rest interval. Each assessed player participated in only one SM and one OM...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28137624/incorporation-of-a-bi-functional-protein-fimh-enhances-the-immunoprotection-of-chitosan-pvp1-vaccine-against-coxsackievirus-b3-induced-myocarditis
#16
Xiangmei Fan, Yan Yue, Sidong Xiong
Viral myocarditis is a common clinical cardiovascular disease mainly induced by coxsackievirus B3 (CVB3) with no effective therapeutic measures. Induction of efficient mucosal immune responses is very critical against CVB3-induced myocarditis. FimH is an Escherichia coli (E. coli)-derived protein, which possesses an M cell-targeting property and functions as a TLR4 agonist. In this study, we introduced the recombinant FimH protein, into our previously developed CVB3 mucosal vaccine chitosan (CS)-pVP1, aiming to provoke more efficient mucosal immune responses and immunoprotection against CVB3-induced myocarditis...
April 2017: Antiviral Research
https://www.readbyqxmd.com/read/28118501/immunoglobulin-a-and-nutrients-in-milk-from-great-apes-throughout-lactation
#17
Miriam Garcia, Michael L Power, Kasey M Moyes
Differences in macronutrients between human and ape milks appear relatively small, but variation in other components such as immunoglobulins (Ig) may be greater. This study characterized the macronutrient and secretory (sIgA) profiles in milk from gorillas and orangutans throughout lactation. Fifty-three milk samples from four gorillas and three orangutans were collected throughout 48 and 22 months postpartum (MPP), respectively. Samples were grouped in five stages of lactation (0 to 6 months, more than 6 months to 12 months, more than 12 months to 18 months, more than 18 months to 36 months, and more than 36 months to 48 months)...
March 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28115360/saccharomyces-boulardii-administration-can-inhibit-the-formation-of-gastric-lymphoid-follicles-induced-by-helicobacter-suis-infection
#18
Lin Yang, Zi-Bin Tian, Ya-Nan Yu, Cui-Ping Zhang, Xiao-Yu Li, Tao Mao, Xue Jing, Wen-Jun Zhao, Xue-Li Ding, Ruo-Ming Yang, Shuai-Qing Zhang
Helicobacter suis has a greater tendency to induce gastric mucosa-associated lymphoid tissue (MALT) lymphoma compared with other Helicobacter species in humans and animals. Saccharomyces (S.) boulardii has been established as an adjunct to Helicobacter pylori eradication treatment, but the effect of S. boulardii administration alone on Helicobacter infection remains unclear. Here, we found that S. boulardii administration effectively decreased the bacterial load of Helicobacter suis and inhibited the formation of lymphoid follicles in the stomach post-infection...
January 22, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28066935/effects-of-corn-distillers-dried-grains-with-solubles-on-performance-oxidative-status-intestinal-immunity-and-meat-quality-of-chinese-yellow-broilers
#19
D Ruan, S Q Jiang, Y J Hu, F Y Ding, Q L Fan, F Chen, X J Lin, L Li, Y Wang
The study assessed the effects of different dietary levels of corn distillers dried grains with solubles (DDGS) on performance, oxidation status, intestinal immunity and meat quality in Chinese Yellow broilers aged from 1 to 63 days. Lingnan male hatchings (1440) were randomly assigned to six treatments, each consisting of six replicates of 40 birds. The basal diet (I) was a typical corn-soya bean ration while the experimental diets (II to VI) partially substituted corn DDGS for soya bean meal. The level of substitution in starter, grower and finisher diets was as follows: II, 2%, 4% then 6%; III, 4%, 8% then 12%; IV, 6%, 12% then 18%; V, 8%, 16% then 24%; VI, 10%, 20% then 30%...
January 8, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28061998/effects-of-mycoplasma-hyopneumoniae-on-porcine-nasal-cavity-dendritic-cells
#20
Yumeng Shen, Weiwei Hu, Yanna Wei, Zhixin Feng, Qian Yang
Mycoplasma hyopneumoniae (Mhp) is the primary etiological agent responsible for swine enzootic pneumonia (EP), a disease that cause tremendous economic losses all over the swine industry. Dendritic cells (DCs), the most effective antigen-presenting cells, are widely distributed beneath respiratory epithelium. DCs uptake and present antigens to T cells, to initiate protective immune responses or generate immune-mediated pathology in different infections. In this study, we investigated the changes in the different DCs subpopulations, T cells and SIgA positive cells counts in porcine nasal cavity after long time Mhp infection...
January 2017: Veterinary Microbiology
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