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https://www.readbyqxmd.com/read/27911098/siga-deficiency-in-individual-small-airways-is-associated-with-persistent-inflammation-and-remodeling
#1
Vasiliy V Polosukhin, Bradley W Richmond, Rui-Hong Du, Justin M Cates, Pingsheng Wu, Hui Nian, Pierre P Massion, Lorraine B Ware, Jae Woo Lee, Alexey V Kononov, William E Lawson, Timothy S Blackwell
RATIONALE: Maintenance of a surface immune barrier is important for homeostasis in organs with mucosal surfaces that interface with the external environment; however, the role of the mucosal immune system in chronic lung diseases is incompletely understood. OBJECTIVES: We examined the relationship between secretory immunoglobulin A (SIgA) on the mucosal surface of small airways and parameters of inflammation and airway wall remodeling in chronic obstructive pulmonary disease (COPD)...
December 2, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27908847/homeostasis-of-the-gut-barrier-and-potential-biomarkers
#2
Jerry M Wells, Robert J Brummer, Muriel Derrien, Thomas T MacDonald, Freddy Troost, Patrice D Cani, Vassilia Theodorou, Jan Dekker, Agnes Méheust, Willem M de Vos, Annick Mercenier, Arjen Nauta, Clara L Garcia-Rodenas
The gut barrier plays a crucial role by spatially compartmentalizing bacteria to the lumen through the production of secreted mucus and is fortified by the production of sIgA and antimicrobial peptides and proteins. With exception of sIgA the expression of these protective barrier factors is largely controlled by innate immune recognition of microbial molecular ligands. Several specialized adaptations and checkpoints are operating in the mucosa to scale the immune response according to the threat and prevent overreaction to the trillions of symbionts inhabiting the human intestine...
December 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27908830/protective-efficacy-of-fc-targeting-conserved-influenza-virus-m2e-antigen-expressed-by-lactobacillus-plantarum
#3
Wen-Tao Yang, Gui-Lian Yang, Qian Wang, Hai-Bin Huang, Yan-Long Jiang, Chun-Wei Shi, Jian-Zhong Wang, Ke-Yan Huang, Yu-Bei Jin, Chun-Feng Wang
The influenza A (H1N1) virus is a highly contagious acute respiratory disease affecting pigs and humans. This disease causes severe economic loss in many countries, and developing mucosal vaccines is an efficient strategy to control the influenza virus. The neonatal Fc receptor (FcRn) plays an important role in transferring IgG across polarized epithelial cells. In the present study, an oral vaccine was developed using Lactobacillus plantarum to deliver the internal influenza viral protein M2e fused to an IgG Fc fragment...
November 28, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27907037/reliability-of-potential-pain-biomarkers-in-the-saliva-of-healthy-subjects-inter-individual-differences-and-intersession-variability
#4
Eva M Sobas, Roberto Reinoso, Rubén Cuadrado-Asensio, Itziar Fernández, Miguel J Maldonado, José C Pastor
AIM: Salivary cortisol, α-amylase (sAA), secretory IgA (sIgA), testosterone, and soluble fraction of receptor II of TNFα (sTNFαRII) could serve as objective pain measures, but the normal variability of these potential biomarkers is unknown. PATIENTS & METHODS: Saliva was collected with the passive secretion method from 34, pain-free subjects in two single samples at least 24 hours apart. Biomarker variation and intersession reliability were assessed with the intraclass correlation coefficient (ICC)...
2016: PloS One
https://www.readbyqxmd.com/read/27900246/siga-peroxidase-and-collagenase-in-saliva-of-smokers-aggressive-periodontal-patients
#5
Myriam A Koss, Cecilia E Castro, Agustina M Gramajo, María E López
BACKGROUND: Tobacco smoking is strongly associated with destructive periodontal disease, alveolar bone loss and poor response to periodontal therapy. The aim of this study was to investigate the effect of smoking on antimicrobials and destructive proteins in the saliva of patients with generalized aggressive periodontal disease. MATERIAL AND METHODS: The study group consisted of 55 adult subjects. They were classified according to their clinical diagnoses either as having generalized aggressive periodontitis (n = 27; 13 smokers and 14 non-smokers) or as periodontitis-free control group (n = 28; 14 smokers and 14 non-smokers)...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27860074/immunogenicity-of-recombinant-lactobacillus-casei-expressing-f4-k88-fimbrial-adhesin-faeg-in-conjunction-with-a-heat-labile-enterotoxin-a-ltak63-and-heat-labile-enterotoxin-b-ltb-of-enterotoxigenic-escherichia-coli-as-an-oral-adjuvant-in-mice
#6
Meiling Yu, Ruiming Qi, Chaoyang Chen, Jiyuan Yin, Sunting Ma, Wen Shi, Yang Wu, Junwei Ge, Yanping Jiang, Lijie Tang, Yigang Xu, Yijing Li
AIMS: The aims of this study were to develop an effective oral vaccine against enterotoxigenic Escherichia coli (ETEC) infection and to design new and more versatile mucosal adjuvants. METHODS AND RESULTS: Genetically engineered Lactobacillus casei strains expressing F4 (K88) fimbrial adhesin FaeG (rLpPG-2-FaeG) and either co-expressing heat-labile enterotoxin A (LTA) subunit with an amino acid mutation associated with reduced virulence (LTAK63) and a heat-labile enterotoxin B (LTB) subunit of E...
November 17, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27853117/assessing-the-archaeoparasitological-potential-of-quids-as-a-source-material-for-immunodiagnostic-analyses
#7
Johnica J Morrow, Karl J Reinhard
In the present study, quids from La Cueva de los Muertos Chiquitos (CMC) were subjected to ELISA tests for 2 protozoan parasites, Toxoplasma gondii (n=45) and Trypanosoma cruzi (n=43). The people who occupied CMC, the Loma San Gabriel, lived throughout much of present-day Durango and Zacatecas in Mexico. The known pathoecology of these people puts them into at-risk categories for the transmission of T. gondii and T. cruzi. Human antibodies created in response to these 2 parasites can be detected in modern saliva using ELISA kits intended for use with human serum...
October 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/27849237/immunology-of-breast-milk
#8
Patricia Palmeira, Magda Carneiro-Sampaio
In the critical phase of immunological immaturity of the newborn, particularly for the immune system of mucous membranes, infants receive large amounts of bioactive components through colostrum and breast milk. Colostrum is the most potent natural immune booster known to science. Breastfeeding protects infants against infections mainly via secretory IgA (SIgA) antibodies, but also via other various bioactive factors. It is striking that the defense factors of human milk function without causing inflammation; some components are even anti-inflammatory...
September 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27849116/reliability-of-salivary-cortisol-and-immunoglobulin-a-measurements-from-the-ipro%C3%A2-before-and-after-sprint-cycling-exercise
#9
Luke A Macdonald, Phillip M Bellinger, Clare L Minahan
BACKGROUND: The purpose of this study was to evaluate the inter-day reliability of the IPRO method for determining resting and post-exercise salivary cortisol (sCort) and rate of salivary Immunoglobulin-A (sIgA) secretion. METHODS: Fourteen males (32±11 years) performed two trials (T1 and T2) separated by 7 d, comprising saliva sampling before and 15 min after completion of two, 30-s Wingate Anaerobic Tests separated by 3.5 min (2 x WAnT). sCort increased after the 2 x WAnT in both trials (T1: p<0...
November 16, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27847366/comparisons-of-the-humoral-and-cellular-immune-responses-induced-by-live-attenuated-influenza-vaccine-laiv-and-inactivated-influenza-vaccine-iiv-in-adults
#10
Daniel F Hoft, Kathleen R Lottenbach, Azra Blazevic, Aldin Turan, Tamara P Blevins, Thomas P Pacatte, Yinyi Yu, Michelle C Mitchell, Stella G Hoft, Robert B Belshe
Both live attenuated influenza vaccine (LAIV) and inactivated influenza vaccines (IIV) induce protective immunity against influenza. There is evidence that LAIV induces superior protection in children, whereas IIV may induce superior protection in adults. The immune mechanisms responsible for these differences have not been identified. We previously compared LAIV and IIV in young children 6-36 months of age, and demonstrated that while both induced similar hemagglutination-inhibiting (HAI) antibody responses, only LAIV induced significant increases in T cell responses...
November 9, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27845173/comparative-innate-immune-interactions-of-human-and-bovine-secretory-iga-with-pathogenic-and-non-pathogenic-bacteria
#11
Alison J Hodgkinson, Julie Cakebread, Megan Callaghan, Paul Harris, Rachel Brunt, Rachel C Anderson, Kelly M Armstrong, Brendan Haigh
Secretory IgA (SIgA) from milk contributes to early colonization and maintenance of commensal/symbiotic bacteria in the gut, as well as providing defence against pathogens. SIgA binds bacteria using specific antigenic sites or non-specifically via its glycans attached to α-heavy-chain and secretory component. In our study, we tested the hypothesis that human and bovine SIgA have similar innate-binding activity for bacteria. SIgAs, isolated from human and bovine milk, were incubated with a selection of commensal, pathogenic and probiotic bacteria...
November 11, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27817960/multifaceted-immune-responses-and-protective-efficacy-elicited-by-a-recombinant-autolyzed-salmonella-expressing-flic-flagellar-antigen-of-f18-escherichia-coli
#12
Gayeon Won, John Hwa Lee
Porcine edema disease (ED) caused by F18(+) Shiga toxin 2e-producing Escherichia coli (STEC) has imposed significant economic losses in the swine industry worldwide, resulting in sudden deaths in post-weaned piglets. The flagellin protein of F18(+) STEC, a structural component of the flagellar filament, is a known virulence factor that mediates adhesion and invasion to porcine epithelial cells. In this study, Salmonella inactivated by the E lysis gene and expressing the flagellin (fliC) antigen was genetically engineered utilizing a plasmid (pMMP184) carrying an efficient heterologous antigen delivery system...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27801789/administration-of-a-multi-strain-probiotic-product-to-women-in-the-perinatal-period-differentially-affects-the-breast-milk-cytokine-profile-and-may-have-beneficial-effects-on-neonatal-gastrointestinal-functional-symptoms-a-randomized-clinical-trial
#13
Maria Elisabetta Baldassarre, Antonio Di Mauro, Paola Mastromarino, Margherita Fanelli, Domenico Martinelli, Flavia Urbano, Daniela Capobianco, Nicola Laforgia
BACKGROUND: Probiotic supplementation to women during pregnancy and lactation can modulate breast milk composition, with immune benefits being transferred to their infants. AIM: The aim of the study was to evaluate the effect of high-dose probiotic supplementation to women during late pregnancy and lactation on cytokine profile and secretory IgA (sIgA) in breast milk and thus to study if differences in breast milk composition can affect lactoferrin and sIgA levels in stool samples of newborns...
October 27, 2016: Nutrients
https://www.readbyqxmd.com/read/27760036/three-step-anti-ampv-iga-expression-profile-evaluation-in-turkeys-of-different-immunological-status-after-trt-vaccination
#14
M Śmiałek, B Tykałowski, D Pestka, J Welenc, T Stenzel, A Koncicki
Maternally derived antibodies (MDA) don not protect turkeys against rhinotracheitis (TRT) but high MDA influences upper respiratory tract (URT) immunity stimulation after avian Metapneumovirus (aMPV) vaccination. Humoral immunity can not be considered as an indicator of protection against TRT, but specific antibodies inhibit aMPV replication and alleviate the course of TRT. Scarce reports indicate the role of IgA in protection against TRT. The aim of our study was to investigate the impact of MDA on stimulation, antigen specificity acquisition of B lymphocytes, and the production of specific IgA after TRT vaccination of turkeys...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27754716/storage-of-unfed-and-leftover-pasteurized-human-milk
#15
Ting Meng, Maryanne T Perrin, Jonathan C Allen, Jason Osborne, Frances Jones, April D Fogleman
OBJECTIVE: To determine the impact of storage on bacterial growth and immunological activity of pasteurized human milk and leftover pasteurized human milk that has been exposed to the microflora in an infant's mouth. MATERIALS AND METHODS: Eighteen mother-infant dyads participated in two separate studies. Mother's milk was pasteurized, and each baby was fed 1 to 2 ounces. Pasteurized and leftover pasteurized milk were stored at room (24°C) and refrigerated temperatures (4°C)...
October 18, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27716047/intranasal-immunization-with-recombinant-toxoplasma-gondii-actin-depolymerizing-factor-confers-protective-efficacy-against-toxoplasmosis-in-mice
#16
Zhuanzhuan Liu, Litian Yin, Yaqing Li, Fei Yuan, Xiaofan Zhang, Jiazhi Ma, Hongmei Liu, Yanjuan Wang, Kuiyang Zheng, Jianping Cao
BACKGROUND: Toxoplasma gondii is an opportunistic protozoan closely associated with AIDS and vertical transmission. T. gondii actin depolymerizing factor (TgADF) plays an important role in actin cytoskeleton remodeling, and it is required to invade host cells. TgADF was a promising vaccine candidate. To observe the immunological changes and protective efficacy of recombinant TgADF protein (rTgADF) against T. gondii infection, we optimized the intranasal immunization dose of rTgADF and analyzed the survival rate and tachyzoite loads in mouse tissues after oral challenge with T...
October 6, 2016: BMC Immunology
https://www.readbyqxmd.com/read/27696326/tlr4-and-tlr21-expression-mif-ifn-%C3%AE-md-2-cd14-activation-and-siga-production-in-chickens-administered-with-efal41-strain-challenged-with-campylobacter-jejuni
#17
Karaffová V, Marcinková E, Bobíková K, Herich R, Revajová V, Stašová D, Kavuľová A, Levkutová M, Levkut M, Lauková A, Ševčíková Z, Levkut M
The protective effect of Enterococcus faecium EFAL41 on chicken's caecum in relation to the TLR (TLR4 and TLR21) activation and production of luminal IgA challenged with Campylobacter jejuni CCM6191 was assessed. The activation of MIF, IFN-β, MD-2 and CD14 was followed-up after bacterial infection. Day-old chicks (40) were divided into four groups (n = 10): control (C), E. faecium AL41 (EFAL41), C. jejuni (CJ) and combined E. faecium AL41+C. jejuni (EFAL41+CJ). Relative mRNA expression of TLR4, TLR21 and CD14 was upregulated in the probiotic strain and infected (combined) group on day 4 and 7 post infection (p...
October 3, 2016: Folia Microbiologica
https://www.readbyqxmd.com/read/27693834/effects-of-polysaccharide-from-mycelia-of-ganoderma-lucidum-on-intestinal-barrier-functions-of-rats
#18
Mingliang Jin, Yimin Zhu, Dongyan Shao, Ke Zhao, Chunlan Xu, Qi Li, Hui Yang, Qingsheng Huang, Junling Shi
The intestinal mucosal barriers play essential roles not only in the digestion and absorption of nutrients, but also the innate defense against most intestinal pathogens. In the present study, polysaccharide from the mycelia of Ganoderma lucidum was given via oral administration to rats (100mg/kg body weight, 21days) to investigate its effects on intestinal barrier functions, including the mechanical barrier, immunological barrier and biological barrier function. It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-κB p65 (NF-κB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-γ (IFN-γ), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase (DAO) in serum...
September 29, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27692097/secretory-immunoglobulin-a-and-immunoglobulin-g-in-horse-saliva
#19
Anna-Karin E Palm, Ove Wattle, Torbjörn Lundström, Eva Wattrang
This study aimed to increase the knowledge on salivary antibodies in the horse since these constitute an important part of the immune defence of the oral cavity. For that purpose assays to detect horse immunoglobulin A (IgA) including secretory IgA (SIgA) were set up and the molecular weights of different components of the horse IgA system were estimated. Moreover, samples from 51 clinically healthy horses were tested for total SIgA and IgG amounts in saliva and relative IgG3/5 (IgG(T)) and IgG4/7 (IgGb) content were tested in serum and saliva...
November 1, 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27682136/effect-of-conjugated-linoleic-acid-enriched-butter-after-24-hours-of-intestinal-mucositis-induction
#20
Patrícia Aparecida Vieira de Barros, Simone de Vasconcelos Generoso, Maria Emília Rabelo Andrade, Marco Antonio Sundfeld da Gama, Fernando Cesar Ferraz Lopes, Éricka Lorenna de Sales E Souza, Flaviano Dos Santos Martins, Sued Eustáquio Mendes Miranda, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso
Mucositis is the most common side effect due to chemotherapy or radiotherapy. It refers to the inflammation of intestinal mucous membranes, and it is associated with complications such as diarrhea, weight loss, and increased intestinal permeability (IP). This study was designed to evaluate the effect of diet containing conjugated linoleic acid (CLA)-enriched butter on intestinal damage and inflammatory response after 24 h of 5-fluorouracil (5-FU)-induced mucositis. Mice were divided into four groups: CTL; CLA; 5-FU, and CLA 5-FU, and they were fed for 31 days...
September 28, 2016: Nutrition and Cancer
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