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https://www.readbyqxmd.com/read/28719863/evaluation-of-platelet-adhesion-and-activation-on-polymers-round-robin-study-to-assess-inter-center-variability
#1
S Braune, C Sperling, M F Maitz, U Steinseifer, J Clauser, B Hiebl, S Krajewski, H P Wendel, F Jung
The regulatory agencies provide recommendations rather than protocols or standard operation procedures for the hemocompatibility evaluation of novel materials e.g. for cardiovascular applications. Thus, there is a lack of specifications with regard to test setups and procedures. As a consequence, laboratories worldwide perform in vitro assays under substantially different test conditions, so that inter-laboratory and inter-study comparisons are impossible. Here, we report about a prospective, randomized and double-blind multicenter trial which demonstrates that standardization of in vitro test protocols allows a reproducible assessment of platelet adhesion and activation from fresh human platelet rich plasma as possible indicators of the thrombogenicity of cardiovascular implants...
July 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719858/interfacial-analysis-of-sirna-complexes-with-poly-ethylenimine-pei-or-pamam-dendrimers-in-gene-delivery
#2
Patrick K C Chang, Clive A Prestidge, Kristen E Bremmell
Solution and interfacial analysis has been employed to gain insight into the complexation of siRNA using either G4 PAMAM dendrimers or 25kDa branched poly-ethylenimine (bPEI). The size, charge and shape/structure of the complexing agents were probed using atomic force microscopy (AFM), circular dichroism spectrometry (CD), dynamic light scattering (DLS), and gel electrophoresis (GE). The binding capability of these cationic polymers to the siRNA molecule, subsequently controls the surface/adsorption behaviour of the complexes to a negatively charged surface...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719819/electrical-preconditioning-of-stem-cells-with-a-conductive-polymer-scaffold-enhances-stroke-recovery
#3
Paul M George, Tonya M Bliss, Thuy Hua, Alex Lee, Byeongtaek Oh, Alexa Levinson, Swapnil Mehta, Guohua Sun, Gary K Steinberg
Exogenous human neural progenitor cells (hNPCs) are promising stroke therapeutics, but optimal delivery conditions and exact recovery mechanisms remain elusive. To further elucidate repair processes and improve stroke outcomes, we developed an electrically conductive, polymer scaffold for hNPC delivery. Electrical stimulation of hNPCs alters their transcriptome including changes to the VEGF-A pathway and genes involved in cell survival, inflammatory response, and synaptic remodeling. In our experiments, exogenous hNPCs were electrically stimulated (electrically preconditioned) via the scaffold 1 day prior to implantation...
July 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28719745/highly-efficient-water-decontamination-by-using-sub-10-nm-feooh-confined-within-millimeter-sized-mesoporous-polystyrene-beads
#4
Xiaolin Zhang, Cheng Cheng, Jieshu Qian, Zhenda Lu, Siyuan Pan, Bing-Cai Pan
Millimeter-sized polymer-based FeOOH nanoparticles (NPs) provide a promising option to overcome the bottlenecks of direct use of NPs in scaled-up water purification, and decreasing the NP size below 10 nm is expected to improve the decontamination efficiency of the polymeric nanocomposites due to the size and surface effect. However, it is still challenging to control the dwelled FeOOH NP sizes to sub-10 nm, mainly due to the wide pore size distribution of the currently available polymeric hosts. Herein, we synthesized mesoporous polystyrene beads (MesoPS) via flash freezing to assemble FeOOH NPs...
July 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28719648/oligo-ethylene-glycol-sidechain-microgels-prepared-in-absence-of-cross-linking-agent-polymerization-characterization-and-variation-of-particle-deformability
#5
Nicole Welsch, L Andrew Lyon
We present a systematic study of self-cross-linked microgels formed by precipitation polymerization of oligo ethylene glycol methacrylates. The cross-linking density of these microgels and, thus, the network flexibility can be easily tuned through the modulation of the reaction temperature during polymerization. Microgels prepared in absence of any difunctional monomer, i.e. cross-linker, show enhanced deformability and particle spreading on solid surfaces as compared to microgels cross-linked with varying amounts of poly(ethylene glycol diacrylate) (PEG-DA) in addition to self-crosslinking...
2017: PloS One
https://www.readbyqxmd.com/read/28719374/physical-and-chemical-stability-of-budesonide-mucoadhesive-oral-suspensions-mucolox
#6
Kendice Ip, Maria Carvalho, Ashley Shan, Daniel Banov
Budesonide is a corticosteroid that has been shown effective in the treatment of eosinophilic esophagitis, but there are currently no commercial medicines to treat this chronic allergic/immune condition, despite its prevalence in the U.S. Therefore, pharmaceutical compounding is the alternative choice to meet the therapeutic need of eosinophilic esophagitis patients. Two budesonide mucoadhesive oral suspensions (1 mg/10 mL and 2 mg/10 mL) were developed using the compounding vehicle MucoLox, a proprietary mucoadhesive polymer blend that promotes mucosal adhesion...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28719217/single-molecule-study-on-polymer-nanoparticle-interactions-the-particle-shape-matters
#7
Zhandong Li, Bin Zhang, Yu Song, Yurui Xue, Lixin Wu, Wenke Zhang
The study on the nanoparticle-polymer interactions is very important for the design/preparation of high performance polymer nanocomposite. Here we present a method to quantify the polymer-particle interaction at single molecule level by using AFM-based single molecule force spectroscopy (SMFS). As a proof-of-concept study, we choose Poly-L-Lysine (PLL) as the polymer and several different types of polyoxometalates (POM) as the model particles to construct several different polymer nanocomposites and to reveal the binding mode and quantify the binding strength in these systems...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28719186/elastomer-reinforced-with-regenerated-chitin-from-alkaline-urea-aqueous-system
#8
Peng Yu, Hui He, Yuanfang Luo, Demin Jia, Alain Dufresne
Novel hybrid elastomer/regenerated chitin (R-chitin) composites were developed, for the first time, by introducing chitin solution (dissolved in alkaline/urea aqueous solution at low temperature) into rubber latex, and then co-coagulating using ethanol as the co-coagulant. During the rapid co-precipitation process, the chitin solution showed rapid coagulant-induced gelation and a porous chitin phase was generated, while the rubber latex particles were synchronously demulsificated to form the rubbery phase. The two phases interlaced and interpenetrated simultaneously to form an Interpenetrating Polymer Network (IPN) structure, which was evidenced by SEM observation...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28719102/plant-viral-and-bacteriophage-delivery-of-nucleic-acid-therapeutics
#9
REVIEW
Patricia Lam, Nicole F Steinmetz
Nucleic acid therapeutics have emerged as a powerful method for treatment of many diseases. However, the challenge lies in safe and efficient delivery of nucleic acids to their target site, as they need to cross various extracellular and intracellular barriers. Mammalian viruses have initially been favored for delivery of nucleic acid therapeutics, but safety concerns regarding their immunogenicity and potential of integration have fueled the search for alternative delivery strategies. For example, chemistry and bioengineering have led to advances in the use of nonviral vectors composed of lipids and other polymers; nevertheless, the synthetic systems often do not match the efficiency achieved using the biological systems...
July 18, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28719095/a-new-perspective-on-transparent-wood-lignin-retaining-transparent-wood
#10
Yuanyuan Li, Qiliang Fu, Ramiro Rojas, Min Yan, Martin Lawoko, Lars Berglund
Optically transparent wood, combining optical and mechanical performance, is an emerging new material for light transmitting structures in buildings with the aim of reducing energy consumption. One of the main obstacles for transparent wood fabrication is delignification, where around 30 wt% of wood tissue is removed to reduce light absorption and refractive index mismatch. This step is time consuming and not environmentally benign. Meanwhile, lignin removal weakens the wood structure, limiting the fabrication of large structure...
July 18, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28719063/enhanced-fibrinolysis-with-magnetically-powered-colloidal-microwheels
#11
Tonguc O Tasci, Dante Disharoon, Rogier M Schoeman, Kuldeepsinh Rana, Paco S Herson, David W M Marr, Keith B Neeves
Thrombi that occlude blood vessels can be resolved with fibrinolytic agents that degrade fibrin, the polymer that forms between and around platelets to provide mechanical stability. Fibrinolysis rates however are often constrained by transport-limited delivery to and penetration of fibrinolytics into the thrombus. Here, these limitations are overcome with colloidal microwheel (µwheel) assemblies functionalized with the fibrinolytic tissue-type plasminogen activator (tPA) that assemble, rotate, translate, and eventually disassemble via applied magnetic fields...
July 18, 2017: Small
https://www.readbyqxmd.com/read/28719022/engineering-the-surface-of-smart-nanocarriers-using-a-ph-thermal-gsh-responsive-polymer-zipper-for-precise-tumor-targeting-therapy-in-vivo
#12
Penghui Zhang, Yan Wang, Jing Lian, Qi Shen, Chen Wang, Bohan Ma, Yuchao Zhang, Tingting Xu, Jianxin Li, Yongping Shao, Feng Xu, Jun-Jie Zhu
Nanocarrier surface chemistry plays a vital role in mediating cell internalization and enhancing delivery efficiency during in vivo chemotherapy. Inspired by the ability of proteins to alter their conformation to mediate functions, a pH-/thermal-/glutathione-responsive polymer zipper consisting of cell-penetrating poly(disulfide)s and thermosensitive polymers bearing guanidinium/phosphate (Gu(+) /pY(-) ) motifs to spatiotemporally tune the surface composition of nanocarriers for precise tumor targeting and efficient drug delivery is developed...
July 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28719004/development-of-new-supramolecular-lyotropic-liquid-crystals-and-their-application-as-alignment-media-for-organic-compounds
#13
Martin Leyendecker, Nils-Christopher Meyer, Christina Thiele
Most alignment media for the residual dipolar coupling (RDC) based molecular structure determination of small organic compounds consist of rod-like polymers dissolved in organic solvents or of swollen cross-linked polymer gels. So far the synthesis of polymer based alignment media is a challenging process which is often followed by a time consuming sample preparation. We propose the use of non-polymeric alignment media based on benzene-tricarboxamides (BTA) which self-assemble into rod-like supramolecules. Our newly found supramolecular lyotropic liquid crystals (LLC) are characterized for LLC properties and their suitability as alignment medium in NMR spectroscopy...
July 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28718832/application-of-carbon-nanotubes-in-chiral-and-achiral-separations-of-pharmaceuticals-biologics-and-chemicals
#14
REVIEW
Ayman L Hemasa, Nenad Naumovski, William A Maher, Ashraf Ghanem
Carbon nanotubes (CNTs) possess unique mechanical, physical, electrical and absorbability properties coupled with their nanometer dimensional scale that renders them extremely valuable for applications in many fields including nanotechnology and chromatographic separation. The aim of this review is to provide an updated overview about the applications of CNTs in chiral and achiral separations of pharmaceuticals, biologics and chemicals. Chiral single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) have been directly applied for the enantioseparation of pharmaceuticals and biologicals by using them as stationary or pseudostationary phases in chromatographic separation techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and gas chromatography (GC)...
July 18, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28718825/olive-mill-waste-enhances-%C3%AE-glucan-content-in-the-edible-mushroom-pleurotus-eryngii
#15
Sharon Avni, Nirit Ezove, Hilla Hanani, Itamar Yadid, Michal Karpovsky, Hilla Hayby, Ofer Gover, Yitzhak Hadar, Betty Schwartz, Ofer Danay
Mushroom polysaccharides are edible polymers that have numerous reported biological functions; the most common effects are attributed to β-glucans. In recent years, it became apparent that the less abundant α-glucans also possess potent effects in various health conditions. Here we explore several Pleurotus species for their total, β and α-glucan content. Pleurotus eryngii was found to have the highest total glucan concentrations and the highest α-glucans proportion. We also found that the stalks (stipe) of the fruit body contained higher glucan content then the caps (pileus)...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28718807/melanin-and-melanin-related-polymers-as-materials-with-biomedical-and-biotechnological-applications-cuttlefish-ink-and-mussel-foot-proteins-as-inspired-biomolecules
#16
REVIEW
Francisco Solano
The huge development of bioengineering during the last years has boosted the search for new bioinspired materials, with tunable chemical, mechanical, and optoelectronic properties for the design of semiconductors, batteries, biosensors, imaging and therapy probes, adhesive hydrogels, tissue restoration, photoprotectors, etc. These new materials should complement or replace metallic or organic polymers that cause cytotoxicity and some adverse health effects. One of the most interesting biomaterials is melanin and synthetic melanin-related molecules...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28718785/uv-surface-treatment-of-fungal-resistant-polyether-polyurethane-film-induced-growth-of-entomopathogenic-fungi
#17
Gabriela Albara Lando, Letícia Marconatto, Felipe Kessler, William Lopes, Augusto Schrank, Marilene Henning Vainstein, Daniel Eduardo Weibel
Synthetic polymers are the cause of some major environmental impacts due to their low degradation rates. Polyurethanes (PU) are widely used synthetic polymers, and their growing use in industry has produced an increase in plastic waste. A commercial polyether-based thermoplastic PU with hydrolytic stability and fungus resistance was only attacked by an entomopathogenic fungus, Metarhiziumanisopliae, when the films were pre-treated with Ultraviolet (UV) irradiation in the presence of reactive atmospheres. Water contact angle, Fourier transform infrared spectroscopy in attenuated total reflection mode (FTIR-ATR), scanning electron microscopy (SEM), and profilometer measurements were mainly used for analysis...
July 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28718651/organization-of-microgels-at-the-air-water-interface-under-compression-role-of-electrostatics-and-cross-linking-density
#18
Christine Picard, Patrick Garrigue, Marie-Charlotte Tatry, Véronique Lapeyre, Serge Ravaine, Véronique Schmitt, Valerie Ravaine
Poly(N-isopropylacrylamide) (pNIPAM) microgels are soft and deformable particles, which can adsorb at liquid interfaces. In the present paper, we study the two-dimensional organization of charged and quasi-neutral microgels with different cross-linking densities, under compression at the air-water interface and the transfer of the microgel monolayer onto a solid substrate at different surface pressures. At low cross-linking densities, the microgels form highly ordered hexagonal lattices on the solid substrate over large areas, with a unique lattice parameter which decreases continuously as the surface pressure increases...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28718650/self-regulated-nanoparticle-assembly-at-liquid-liquid-interfaces-a-route-to-adaptive-structuring-of-liquids
#19
Caili Huang, Mengmeng Cui, Zhiwei Sun, Feng Liu, Brett A Helms, Thomas P Russell
The controlled structuring of liquids into arbitrary shapes can be achieved in biphasic liquid media using the interfacial assemblies of nanoparticle surfactants (NP-surfactants), that consist of a polar nanoparticle "head group" bound to one or more hydrophobic polymer "tails". The non-equilibrium shapes of the suspended liquid phase can be rendered permanent by the jamming of the NP-surfactants formed and assembled at the interface between the liquids as the system attempts to minimize the interfacial area between the liquids...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28718618/graphene-oxide-by-uv-ozone-treatment-as-efficient-hole-extraction-layer-for-highly-efficient-and-stable-polymer-solar-cells
#20
Yingdong Xia, Yufeng Pan, Haijuan Zhang, Jian Qiu, Yiting Zheng, YongHua Chen, Wei Huang
Hole extraction layer has significant impact on achieving high-efficiency polymer solar cells (PSCs). Here, we report an efficient approach to by direct UV-Ozone treatment larger device performance enhancement employing grapheme oxide (GO). The dramatically performance enhancement of PSCs with P3HT:PCBM blend as an active layer was demonstrated by UV-Ozone treated GO for 30 min: best PCE of 4.18%, FF of 0.63, Jsc of 10.94 mA cm-2, and Voc of 0.61 V, which is significantly higher than the untreated GO (1.82%) and highly comparable PEDOT:PSS-based PSCs (3...
July 18, 2017: ACS Applied Materials & Interfaces
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