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https://www.readbyqxmd.com/read/28109057/comparison-of-two-biodegradable-polymer-based-sirolimus-eluting-stents-with-varying-elution-and-absorption-kinetics-in-patients-with-acute-myocardial-infarction-a-subgroup-analysis-of-the-panda-iii-trial
#1
Changdong Guan, Bo Xu, Shubin Qiao, Lei Qin, Yi Li, Zhanquan Li, Yong Guo, Zhongwei Sun, Lei Song, Runlin Gao
BACKGROUND: Implantation of early-generation metallic drug-eluting stents (DES) in patients with acute myocardial infarction (AMI) is associated with poor vessel wall healing. Use of biodegradable polymer (BP) DES might improve safety outcomes; however, the impact of varying drug elution and polymer absorption kinetics of BP-DES on clinical outcomes in the AMI population is unknown. METHODS: This subgroup analysis of the randomized PANDA III trial included 732 patients (366 in each group) presenting with recent (<1 month) AMI...
January 21, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28108973/development-and-evaluation-of-buccal-films-based-on-chitosan-for-the-potential-treatment-of-oral-candidiasis
#2
G Tejada, M G Barrera, G N Piccirilli, M Sortino, A Frattini, C J Salomón, María C Lamas, Darío Leonardi
In this work, chitosan films were prepared by a casting/solvent evaporation methodology using pectin or hydroxypropylmethyl cellulose to form polymeric matrices. Miconazole nitrate, as a model drug, was loaded into such formulations. These polymeric films were characterized in terms of mechanical properties, adhesiveness, and swelling as well as drug release. Besides, the morphology of raw materials and films was investigated by scanning electron microscopy; interactions between polymers were analyzed by infrared spectroscopy and drug crystallinity studied by differential scanning calorimetry and X-ray diffraction...
January 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28108933/modelling-genome-wide-topological-associating-domains-in-mouse-embryonic-stem-cells
#3
REVIEW
Y Zhan, L Giorgetti, G Tiana
Chromosome conformation capture (3C)-based techniques such as chromosome conformation capture carbon copy (5C) and Hi-C revealed that the folding of mammalian chromosomes is highly hierarchical. A fundamental structural unit in the hierarchy is represented by topologically associating domains (TADs), sub-megabase regions of the genome within which the chromatin fibre preferentially interacts. 3C-based methods provide the mean contact probabilities between chromosomal loci, averaged over a large number of cells, and do not give immediate access to the single-cell conformations of the chromatin fibre...
January 20, 2017: Chromosome Research
https://www.readbyqxmd.com/read/28108411/production-and-characterization-of-medium-chain-length-polyhydroxyalkanoates-copolymer-from-arctic-psychrotrophic-bacterium-pseudomonas-sp-pamc-28620
#4
Ganesan Sathiyanarayanan, Shashi Kant Bhatia, Hun-Suk Song, Jong-Min Jeon, Jun-Young Kim, Yoo Kyung Lee, Yun-Gon Kim, Yung-Hun Yang
Arctic psychrotrophic bacterium Pseudomonas sp. PAMC 28620 was found to produce a distinctive medium-chain-length polyhydroxyalkanoates (MCL-PHAs) copolymer when grown on structurally unrelated carbon sources including glycerol. The maximum MCL-PHAs copolymer yield was obtained about 52.18±4.12% from 7.95±0.66g/L of biomass at 144h of fermentation when 3% glycerol was used as sole carbon and energy source during the laboratory-scale bioreactor process. Characterization of the copolymer was carried out using fourier transform infrared spectroscopy (FTIR), gas chromatography-mass spectrometry (GC-MS), proton ((1)H) and carbon ((13)C) nuclear magnetic resonance spectroscopy (NMR), gel permeation chromatography (GPC), differential scanning calorimeter (DSC) and thermo-gravimetric analysis (TGA)...
January 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28108361/development-and-characterization-of-new-functionalized-polyurethanes-for-sustained-and-site-specific-drug-release-in-the-gastrointestinal-tract
#5
María Dolores Campiñez, Elena Benito, Lucía Romero-Azogil, Ángela Aguilar-de-Leyva, María de Gracia García-Martín, Juan Antonio Galbis, Isidoro Caraballo
The main objective of the present paper has been the development and study of two new biodegradable polyurethanes, PU(dithiodiethanol-DTDI) and PU[((i)Pr)Man-DTDI], to be used as sustained matrix forming excipients. Furthermore, their capacity to act as excipient for colon drug delivery systems has been evaluated. Thus, SeDeM diagrams have been obtained to investigate their suitability to be processed through a direct compression process. Matrices containing 10-30% w/w of the polymers and theophylline anhydrous as model drug have been manufactured...
January 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28108237/poly-trimethylene-carbonate-based-composite-materials-for-reconstruction-of-critical-sized-cranial-bone-defects-in-sheep
#6
Ni Zeng, Anne C van Leeuwen, Dirk W Grijpma, Ruud R M Bos, Roel Kuijer
PURPOSE: The use of ceramic materials in repair of bone defects is limited to non-load-bearing sites. We tested poly(trimethylene carbonate) (PTMC) combined with β-tricalcium phosphate or biphasic calcium phosphate particles for reconstruction of cranial defects. MATERIALS AND METHODS: PTMC-calcium phosphate composite matrices were implanted in cranial defects in sheep for 3 and 9 months. Micro-computed tomography quantification and histological observation were performed for analysis...
December 18, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28107981/recent-progress-challenges-and-trends-in-trace-determination-of-drug-analysis-using-molecularly-imprinted-solid-phase-microextraction-technology
#7
REVIEW
Saeedeh Ansari, Majid Karimi
The quantification of drugs in biological samples is a significant task for determination of the physiological efficiency in evaluated drugs in the drug discovery. To analysis of the chemical compounds at the trace and ultratrace levels, adequate analytical procedures should be applied. Therefore, sample preparation method undoubtedly is the most important stage in the trace determination process. In spite of the great growth of analytical instrumentation during the recent years, sample preparation is still nowadays considered the impasse of the all analytical procedure, especially in drugs analysis...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107979/electrochemical-sensing-platform-based-on-molecularly-imprinted-polymer-decorated-n-s-co-doped-activated-graphene-for-ultrasensitive-and-selective-determination-of-cyclophosphamide
#8
Bintong Huang, Lili Xiao, Haifeng Dong, Xueji Zhang, Wei Gan, Shahid Mahboob, Khalid Abdullah Al-Ghanim, Qunhui Yuan, Yingchun Li
A novel electrochemical sensor has been facilely fabricated by applying composite elements consisting of nitrogen and sulfur co-doped activated graphene (N,S-AGR) and molecularly imprinted polymer (MIP). N,S-AGR was synthesized by one-pot pyrogenation of a mixture of thiourea, KOH and graphene oxide, which was introduced to improve electron transfer capability and surface area of the electrode, while the electro-polymerized MIP layer afforded simultaneous recognition and quantification of cyclophosphamide (CPA) by utilizing Fe(CN)6(3-/4-) as probe to indicate electrical signals...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107966/novel-potentiometric-sensors-for-the-determination-of-the-dinotefuran-insecticide-residue-levels-in-cucumber-and-soil-samples
#9
Maha F Abdel-Ghany, Lobna A Hussein, Noha F El Azab
Five new potentiometric membrane sensors for the determination of the dinotefuran levels in cucumber and soil samples have been developed. Four of these sensors were based on a newly designed molecularly imprinted polymer (MIP) material consisting of acrylamide or methacrylic acid as a functional monomer in a plasticized PVC (polyvinyl chloride) membrane before and after elution of the template. A fifth sensor, a carboxylated PVC-based sensor plasticized with dioctyl phthalate, was also prepared and tested...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107962/a-label-free-electrochemical-immunosensor-based-on-a-new-polymer-containing-aldehyde-and-ferrocene-groups
#10
Xiangyang Zhang, Youming Shen, Youyu Zhang, Guangyu Shen, Haiyan Xiang, Xiaofeng Long
In this work, a novel and convenient strategy for synthesis of a well-defined polymer containing both aldehyde and ferrocene functional groups by grafting 4-hydroxybenzaldehyde and ferrocenecarboxylhydrazide onto linear poly (vinylbenzyl chloride) was developed. The designed polymer film (polymer CAF) could be used as a new support matrix for fabrication of a label-free electrochemical immunosensor with high sensitivity, good stability and repeatability. With human IgG as an analyte model, the proposed electrochemical immunosensor showed a linear concentration range from 0...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107953/visual-detection-of-nucleic-acids-based-on-lateral-flow-biosensor-and-hybridization-chain-reaction-amplification
#11
Na Ying, Chuanjing Ju, Zhongyi Li, Wensen Liu, Jiayu Wan
In this study, a new lateral flow nucleic acid biosensor (LFNAB) using hybridization chain reaction (HCR) for signal amplification was developed for visual detection of nucleic acids with high sensitivity and low cost. A "sandwich-type" detection strategy was employed in our design. The sandwich system of capture probe (CP)/target DNA/reporter probe (RP)-HCR complexes was fabricated as the sensing platform. As the initiator strand, reporter probe propagated a chain reaction of hybridization events between the two hairpin probes modified with biotin, and determined whether long nicked DNA polymers were formed...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107952/lanthanide-coordination-polymer-probe-for-time-gated-luminescence-sensing-of-ph-in-undiluted-human-serum
#12
Yankai Huang, Baoxia Liu, Qi Shen, Xu Zhu, Yuanqiang Hao, Zhu Chang, Fang Xu, Peng Qu, Maotian Xu
Lanthanide coordination polymers (LCPs) have emerged as fascinating materials because of their specific structure and properties. In this work, utilizing hydrosoluble biomolecule of guanosine-5'-monophosphate (GMP) as bridging linker, lanthanide terbium ions (Tb(3+)) as metal nodes, and silver ions (Ag(+)) as sensitizers, we synthesized a pH responsive luminescent lanthanide CP probe of Tb/GMP/Ag. The probe possesses high luminescence due to the sensitization of Ag(+); While in alkaline solutions, Ag(+) in Tb/GMP/Ag immediately binds to OH(-), forming Ag2O precipitation and resulting in a distinct fluorescence quenching of Tb/GMP/Ag...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107941/mil-101-cr-as-matrix-for-sensitive-detection-of-quercetin-by-matrix-assisted-laser-desorption-ionization-mass-spectrometry
#13
Guobin Han, Qiaoling Zeng, Zhongwei Jiang, Tiantian Xing, Chengzhi Huang, Yuanfang Li
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been proven as a useful and advanced technique in the identification of polymers and proteins. However, MALDI-TOF-MS still has the unavoidable drawback of self-signal interference with traditional organic matrices, which could suppress and overlap with the analyte signals in the low-mass region. In this work, MIL-101(Cr), a kind of metal-organic frameworks which possess high molecular weight, π-conjugated 3-D structure, coordinately unsaturated chromium sites (CUS) and strong absorption in the UV range, was employed to replace traditional organic matrices, and it was found that MIL-101(Cr) can dramatically eliminate the background peaks, showing high signal-to-noise level in the analysis of small molecules...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107940/incorporation-of-zeolitic-imidazolate-framework-zif-8-derived-nanoporous-carbons-in-methacrylate-polymeric-monoliths-for-capillary-electrochromatography
#14
Enrique Javier Carrasco-Correa, Andrea Martínez-Vilata, José Manuel Herrero-Martínez, José B Parra, Fernando Maya, Victor Cerdà, Carlos Palomino Cabello, Gemma Turnes Palomino, Frantisek Svec
A series of metal organic frameworks-derived nanoporous carbons originating from zeolitic imidazolate framework-8 (ZIF-8) crystals as precursors have been prepared via varying the preparation conditions. The ZIF-8-derived carbons were subsequently admixed in the methacrylate monomers containing polymerization mixtures and polymerized to obtain monolithic columns for capillary electrochromatography (CEC). The effect of particle size and content of the ZIF-8-derived carbon materials in the polymerization mixture on the performance of the hybrid monolithic columns was investigated in detail...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107905/a-multi-walled-carbon-nanotubes-based-molecularly-imprinted-polymers-electrochemical-sensor-for-the-sensitive-determination-of-hiv-p24
#15
Ya Ma, Xiao-Lei Shen, Qiang Zeng, Hai-Shui Wang, Li-Shi Wang
To develop a rapid, simple and sensitive method for the determination of human immunodeficiency virus p24 (HIV-p24), a novel molecularly imprinted polymers (MIPs) electrochemical sensor was constructed on the surface of a multi-walled carbon nanotubes (MWCNTs) modified glassy carbon electrode (GCE) by surface polymerization using acrylamide (AAM) as functional monomer, N,N'-methylenebisacrylamide (MBA) as cross-linking agent and ammonium persulphate (APS) as initiator. Each modification step was carefully examined by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and scanning electron microscope (SEM)...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107784/exciton-exciton-annihilation-as-a-probe-of-inter-chain-interactions-in-ppv-oligomer-aggregates
#16
Linda A Peteanu, Sanchari Chowdhury, Jurjen Wildeman, Matthew Y Sfeir
One measure of exciton mobility in an aggregate is the efficiency of exciton-exciton annihilation (EEA). Both exciton mobilities and EEA are enhanced for aggregate morphologies in which the distances between chromophores and their relative orientations are favorable for Förster energy transfer. Here this principle is applied to gauge the strength of inter-chain interactions in aggregates of two substituted PPV oligomers of 7 (OPPV7) and 13 (OPPV13) phenylene rings. These are models of the semiconducting conjugated polymer MEH-PPV...
January 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28107743/high-sensitivity-four-layer-polymer-fiber-optic-evanescent-wave-sensor
#17
Xin Xin, Nianbing Zhong, Qiang Liao, Yanyan Cen, Ruohua Wu, Zhengkun Wang
We present a novel four-layer structure consisting of bottom, second, third, and surface layers in the sensing region, for a D-shaped step-index fiber-optic evanescent wave (FOEW) sensor. To reduce the background noise, the surface of the longitudinal section in the D-shaped region is coated with a light-absorbing film. We check the morphologies of the second and surface layers, examine the refractive indices (RIs) of the third and surface layers, and analyze the composition of the surface layer. We also investigate the effects of the thicknesses and RIs of the third and surface layers and the LA film on the light transmission and sensitivity of the FOEW sensors...
January 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28107665/a-%C3%AF-%C3%AF-conjugation-containing-soft-and-conductive-injectable-polymer-hydrogel-highly-efficiently-rebuilds-cardiac-function-after-myocardial-infarction
#18
Rui Bao, Baoyu Tan, Shuang Liang, Ning Zhang, Wei Wang, Wenguang Liu
Previous studies suggested that a stiffer hydrogel system exhibited a better performance to promote heart function after myocardial infarction (MI). However, the nature of myocardium, a tissue that alternately contracts and relaxes with electrical impulses, leads us to hypothesize that a soft and conductive hydrogel may be in favor of mechanical and electrical signals transmission to enhance heart function after MI. In this work, π-π conjugation interaction was first employed to produce a soft injectable hydrogel with conductive property...
January 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28107655/discrimination-between-naphthacene-and-triphenylene-using-cellulose-tris-4-methylbenzoate-and-cellulose-tribenzoate-a-computational-study
#19
Yusuke Murakami, Tohru Shibata, Kazuyoshi Ueda
The mechanisms of naphthacene and triphenylene discrimination using commercially available cellulose tris(4-methylbenzoate) (CMB) and cellulose tribenzoate (CB) chiral stationary phases were investigated using molecular mechanics calculations. Naphthacene and triphenylene could be separated by liquid chromatography on CMB and CB, with triphenylene being eluted earlier than naphthacene on both phases. However, the corresponding separation factor is much larger for CMB than for CB. The docking of these polycyclic aromatic hydrocarbons to the above polymers suggested that the most important sites of CMB and CB for interacting with these hydrocarbons are located at equivalent positions, featuring a space surrounded by main chain glucose units and benzoyl side chains...
January 7, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28107631/overcoming-the-heat-endurance-of-tumor-cells-by-interfering-the-anaerobic-glycolysis-metabolism-for-improved-photothermal-therapy
#20
Wei-Hai Chen, Guo-Feng Luo, Qi Lei, Sheng Hong, Wen-Xiu Qiu, Li-Han Liu, Si-Xue Cheng, Xian-Zheng Zhang
In this study, we developed a general method to decorate plasmonic gold nanorods (GNRs) with a CD44-targeting functional polymer, containing hyaluronic acid (HA) targeting moiety and a small molecule Glut1 inhibitor of diclofenac (DC), to obtain GNR/HA-DC. This nanosystem exhibited the superiority of selectively sensitizing tumor cells for photothermal therapy (PTT) by inhibiting the unique anaerobic glycolysis. Upon specifically targeting CD44, sequentially time-dependent DC release could be achieved by the trigger of hyaluronidase (HAase), which abundantly existed in tumor tissue...
January 20, 2017: ACS Nano
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