keyword
MENU ▼
Read by QxMD icon Read
search

Polymer

keyword
https://www.readbyqxmd.com/read/28231510/lipopolyplex-potentiates-anti-tumor-immunity-of-mrna-based-vaccination
#1
Stefano Persano, Maria L Guevara, Zhaoqi Li, Junhua Mai, Mauro Ferrari, Pier Paolo Pompa, Haifa Shen
mRNA-based vaccines have the benefit of triggering robust anti-cancer immunity without the potential danger of genome integration from DNA vaccines or the limitation of antigen selection from peptide vaccines. Yet, a conventional mRNA vaccine comprising of condensed mRNA molecules in a positively charged protein core structure is not effectively internalized by the antigen-presenting cells. It cannot offer sufficient protection for mRNA molecules from degradation by plasma and tissue enzymes either. Here, we have developed a lipopolyplex mRNA vaccine that consists of a poly-(β-amino ester) polymer mRNA core encapsulated into a 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine/1,2-dioleoyl-sn-glycero-3-phosphatidyl-ethanolamine/1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000 (EDOPC/DOPE/DSPE-PEG) lipid shell...
February 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/28231498/bone-specific-poly-ethylene-sodium-phosphate-bearing-biodegradable-nanoparticles
#2
Yuya Hirano, Yasuhiko Iwasaki
Chemotherapy is the most reliable treatment for osteoporosis and osseous metastases. To facilitate better drug delivery for bone treatments, a novel preparation of polymeric nanoparticles with high affinity to bone has been prepared. Two-step synthesis of cholesteryl-functionalized poly(ethylene sodium phosphate) (Ch-PEPn·Na) was performed via ring-opening polymerization of cyclic phosphoesters and the demethylation. The molecular weight of Ch-PEPn·Na could be well controlled by changing the ratio of cholesterol and cyclic phosphoesters...
February 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28231428/facile-and-reliable-in-situ-polymerization-of-poly-ethyl-cyanoacrylate-based-polymer-electrolytes-towards-flexible-lithium-batteries
#3
Yanyan Cui, Jingchao Chai, Huiping Du, Yulong Duan, Guangwen Xie, Zhihong Liu, Guanglei Cui
ABSTRACT:Polycyanoacrylate is a very promising matrix for polymer electrolyte,which possesses advantages of strong binding and high electrochemical stability owing to the functional nitrile groups. Herein, a facile and reliable in-situ polymerization strategy of poly(ethyl cyanoacrylate) (PECA) based gel polymer electrolytes (GPE) via a high efficient anionic polymerization was introduced consisting of PECA and 4 M LiClO4 in carbonate solvents. The in-situ polymerized PECA gel polymer electrolyte achieved an excellent ionic conductivity (2...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28231319/development-of-a-keratinase-activity-assay-using-recombinant-chicken-feather-keratin-substrates
#4
Hyeon-Su Jin, Seon Yeong Park, Kyungmin Kim, Yong-Jik Lee, Gae-Won Nam, Nam Joo Kang, Dong-Woo Lee
Poultry feathers consist mainly of the protein keratin, which is rich in β-pleated sheets and consequently resistant to proteolysis. Although many keratinases have been identified, the reasons for their substrate specificity towards β-keratin remain unclear due to difficulties in preparing a soluble feather keratin substrate for use in activity assays. In the present study, we overexpressed Gallus gallus chromosomes 2 and 27 β-keratin-encoding genes in Escherichia coli, purified denatured recombinant proteins by Ni2+ affinity chromatography, and refolded by stepwise dialysis to yield soluble keratins...
2017: PloS One
https://www.readbyqxmd.com/read/28231047/original-research-paper-characterization-and-taste-masking-evaluation-of-microparticles-with-cetirizine-dihydrochloride-and-methacrylate-based-copolymer-obtained-by-spray-drying
#5
Aleksandra Amelian, Marta Szekalska, Patrycja Ciosek, Anna Basa, Katarzyna Winnicka
Taste of a pharmaceutical formulation is an important parameter for the effectiveness of pharmacotherapy. Cetirizine dihydrochloride (CET) is a second-generation antihistamine that is commonly administered in allergy treatment. CET is characterized by extremely bitter taste and it is a great challenge to successfully mask its taste; therefore the goal of this work was to formulate and characterize the microparticles obtained by the spray drying method with CET and poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 copolymer (Eudragit E PO) as a barrier coating...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28231007/molecular-dynamics-recrystallization-behavior-and-water-solubility-of-amorphous-anticancer-agent-bicalutamide-and-its-polyvinylpyrrolidone-mixtures
#6
Justyna Szczurek, Marzena Rams-Baron, Justyna Knapik-Kowalczuk, Agata Antosik, Joanna Szafraniec, Witold Jamroz, Mateusz Dulski, Renata Jachowicz, Marian Paluch
In this paper, we investigated the molecular mobility and physical stability of amorphous bicalutamide, a poorly water-soluble drug widely used in prostate cancer treatment. Our broadband dielectric spectroscopy measurements and differential scanning calorimetry studies revealed that amorphous BIC is a moderately fragile material with strong tendency to recrystallize from amorphous state. However, mixing the drug with polymer polyvinylpyrrolidone results in a substantial improvement of physical stability attributed to antiplasticizing effect governing by polymer additive...
February 23, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28230997/universal-exciton-size-in-organic-polymers-is-determined-by-non-local-orbital-exchange-in-tddft
#7
Stefanie A Mewes, Felix Plasser, Andreas Dreuw
The exciton size of the lowest singlet excited state in a diverse set of organic π-conjugated polymers is studied and found to be a universal, system-independent quantity of approximately 7 Å in the single chain picture. With time-dependent density functional theory (TDDFT), its value as well as the overall description of the exciton is almost exclusively governed by the amount of non-local orbital exchange. This is traced back to the lack of the Coulomb attraction between the electron and hole quasiparticles in pure TDDFT, which is reintroduced only with the admixture of non-local orbital exchange...
February 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28230870/colloidal-capsules-nano-and-microcapsules-with-colloidal-particle-shells
#8
REVIEW
Tobias Bollhorst, Kurosch Rezwan, Michael Maas
Utilizing colloidal particles for the assembly of the shell of nano- and microcapsules holds great promise for the tailor-made design of new functional materials. Increasing research efforts are devoted to the synthesis of such colloidal capsules, by which the integration of modular building blocks with distinct physical, chemical, or morphological characteristics in a capsule's shell can result in novel properties, not present in previous encapsulation structures. This review will provide a comprehensive overview of the synthesis strategies and the progress made so far of bringing nano- and microcapsules with shells of densely packed colloidal particles closer to application in fields such as chemical engineering, materials science, or pharmaceutical and life science...
February 23, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28230805/preparation-of-photoirradiation-molecular-imprinting-polymer-for-selective-separation-of-branched-cyclodextrins
#9
Haoran Fan, Jinpeng Wang, Qingran Meng, Xueming Xu, Tianming Fan, Zhengyu Jin
In the present study, photoirradiation molecularly imprinted polymer (MIP) with azobenzene was used as a functional monomer for the selective separation of the branched cyclodextrins. The functional monomer 4-methacryloyloxy azobenzene (MAA) and the molecular template 6-O-α-d-maltosyl-β-cyclodextrin (G2-β-CD) were implemented for the molecular imprinting. The core-shell structure of photoirradiation MIP was visualized by the transmission electron microscopy (TEM). With Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA), we identified that G2-β-CD was imprinted into the polymer and removed from the MIP...
February 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230790/influence-of-chitosan-swelling-behaviour-on-controlled-release-of-tenofovir-from-mucoadhesive-vaginal-systems-for-prevention-of-sexual-transmission-of-hiv
#10
Fernando Notario-Pérez, Araceli Martín-Illana, Raúl Cazorla-Luna, Roberto Ruiz-Caro, Luis-Miguel Bedoya, Aitana Tamayo, Juan Rubio, María-Dolores Veiga
The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug development. Vaginal mucoadhesive tablets can be developed by including natural polymers that have good binding capacity with mucosal tissues, such as chitosan or guar gum, semisynthetic polymers such as hydroxypropylmethyl cellulose, or synthetic polymers such as Eudragit(®) RS...
February 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28230766/extraction-and-identification-of-phlorotannins-from-the-brown-alga-sargassum-fusiforme-harvey-setchell
#11
Yajing Li, Xiaoting Fu, Delin Duan, Xiaoyong Liu, Jiachao Xu, Xin Gao
Phlorotannins are a group of complex polymers of phloroglucinol (1,3,5-trihydroxybenzene), which are unique compounds from marine brown algae. In our present study, a procedure for extraction and enrichment of phlorotannins from S. fusiforme with highly antioxidant potentials was established. After comparison of different extraction methods, the optimal extraction conditions were established as follows. The freeze-dried seaweed powder was extracted with 30% ethanol-water solvent with a solid/liquid ratio of 1:5 at temperature of 25 °C for 30 min...
February 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28230746/oxidation-of-5-chloromethylfurfural-cmf-to-2-5-diformylfuran-dff
#12
Ana I Vicente, Jaime A S Coelho, Svilen P Simeonov, Hristina I Lazarova, Margarita D Popova, Carlos A M Afonso
2,5-Diformylfuran (DFF) is an important biorenewable building block, namely for the manufacture of new polymers that may replace existing materials derived from limited fossil fuel resources. The current reported methods for the preparation of DFF are mainly derived from the oxidation of 5-hydroxymethylfurfural (HMF) and, to a lesser extent, directly from fructose. 5-Chloromethylfurfural (CMF) has been considered an alternative to HMF as an intermediate building block due to its advantages regarding stability, polarity, and availability from glucose and cellulose...
February 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230742/fructose%C3%A2-and%C3%A2-sucrose%C3%A2-intake%C3%A2-increase%C3%A2-exogenous%C3%A2-carbohydrate%C3%A2-oxidation%C3%A2-during%C3%A2-exercise
#13
Jorn Trommelen, Cas J Fuchs, Milou Beelen, Kaatje Lenaerts, Asker E Jeukendrup, Naomi M Cermak, Luc J C van Loon
Peak exogenous carbohydrate oxidation rates typically reach ~1 g∙min-1 during exercise when ample glucose or glucose polymers are ingested. Fructose co-ingestion has been shown to further increase exogenous carbohydrate oxidation rates. The purpose of this study was to assess the impact of fructose co-ingestion provided either as a monosaccharide or as part of the disaccharide sucrose on exogenous carbohydrate oxidation rates during prolonged exercise in trained cyclists. Ten trained male cyclists (VO2peak: 65 ± 2 mL∙kg-1∙min-1) cycled on four different occasions for 180 min at 50% Wmax during which they consumed a carbohydrate solution providing 1...
February 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28230474/unraveling-the-mode-of-action-of-new-promising-polymer-ruthenium-conjugates
#14
António Matos, Fernanda Marques, Rita Francisco, Tiago Moreira, Ana Preto, M Helena Garcia, Andreia Valente
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230346/high-strength-stereolithographic-3d-printed-nanocomposites-graphene-oxide-metastability
#15
Jill Z Manapat, Joey Dacula Mangadlao, Brylee David Buada Tiu, Grace C Tritchler, Rigoberto C Advincula
The weak thermomechanical properties of commercial 3D printing plastics have limited the technology's application mainly to rapid prototyping. In this report, we demonstrate a simple approach that takes advantage of the metastable, temperature-dependent structure of graphene oxide (GO) to enhance the mechanical properties of conventional 3D-printed resins produced by stereolithography (SLA). A commercially available SLA resin was reinforced with minimal amounts of GO nanofillers and thermally annealed at 50 °C and 100 °C for 12 hours...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28230339/simultaneously-enhanced-efficiency-and-stability-of-polymer-solar-cells-by-employing-solvent-additive-and-upside-down-drying-method
#16
Qianqian Sun, Fujun Zhang, Qiaoshi An, Miao Zhang, Xiaoling Ma, Jian Zhang
The morphology of active layer plays an important role in determining the power conversion efficiency (PCE) and stability of polymer solar cells (PSCs), which strongly depends on the dynamic drying process of active layer. In this work, an efficient and universal method was developed to let active layer undergo upside-down drying process in a covered glass petri dish. For the PSCs based on PTB7-Th:PC71BM, the champion PCEs were improved from 8.58% to 9.64% by mixing 3 vol% DIO, further to 10.30% by employing upside-down drying method...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28230319/depletion-of-abundant-human-serum-proteins-by-per-se-imprinted-cryogels-based-on-sample-heterogeneity
#17
Chun Yang, Ya-Ru Liu, Yan Zhang, Jian Wang, Li-Li Tian, Ya-Nan Yan, Wei-Qin Cao, Yu-Yang Wang
Macroporous cryogels were prepared and used to deplete abundant proteins. It was accomplished based on the sample heterogeneity rather than any exogenous assistance. Human serum was added in monomer solutions to synthesize molecularly imprinted polymers (MIPs); therein some abundant proteins were imprinted in the polyacrylamide cryogels. Meanwhile the rare components remained aqueous. Chromatography and electrophoresis showed that albumin, serotransferrin and most globulins were depleted by columns packed with the MIPs...
February 23, 2017: Proteomics
https://www.readbyqxmd.com/read/28230303/unexpectedly-facile-rh-i-catalyzed-polymerization-of-ethynylbenzaldehyde-type-monomers-synthesis-of-polyacetylenes-bearing-reactive-and-easy-transformable-pendant-carbaldehyde-groups
#18
Jan Sedláček, Lucie Havelková, Jiří Zedník, Radek Coufal, Tomáš Faukner, Hynek Balcar, Jiří Brus
The chain coordination polymerization of (ethynylarene)carbaldehydes with unprotected carbaldehyde groups, namely ethynylbenzaldehydes, 1-ethynylbenzene-3,5-dicarboxaldehyde, and 3-[(4-ethynylphenyl)ethynyl]benzaldehyde, is reported for the first time. Polymerization is catalyzed with various Rh(I) catalysts and yields poly(arylacetylene)s with one or two pendant carbaldehyde groups per monomeric unit. Surprisingly, the carbaldehyde groups of the monomers do not inhibit the polymerization unlike the carbaldehyde group of unsubstituted benzaldehyde that acts as a strong inhibitor of Rh(I) catalyzed polymerization of arylacetylenes...
February 23, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28230296/plants-to-polyelectrolytes-theophylline-polymers-and-their-microsphere-synthesis
#19
Ryan Guterman, Markus Antonietti, Jiayin Yuan
To extend fossil oil supplies, sustainable feed stocks for the production of useful reagents and polymers should be harnessed. In this regard, chemicals derived from plants are excellent candidates. While the vast majority of plant sources used for polymer science only contain C x H y O z , alkaloids such as caffeine, nicotine, and theophylline possess nitrogen functionality that can provide new functions for bioderived polymers and their synthesis. In this context, the chemistry of theophylline, a natural product found in chocolate and tea, is exploited to create a cationic "poly(theophylline)" in a straightforward fashion for the first time...
February 23, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28230082/tubz-filament-assembly-dynamics-requires-the-flexible-c-terminal-tail
#20
Maria E Fuentes-Pérez, Rafael Núñez-Ramírez, Alejandro Martín-González, David Juan-Rodríguez, Oscar Llorca, Fernando Moreno-Herrero, Maria A Oliva
Cytomotive filaments are essential for the spatial organization in cells, showing a dynamic behavior based on nucleotide hydrolysis. TubZ is a tubulin-like protein that functions in extrachromosomal DNA movement within bacteria. TubZ filaments grow in a helical fashion following treadmilling or dynamic instability, although the underlying mechanism is unclear. We have unraveled the molecular basis for filament assembly and dynamics combining electron and atomic force microscopy and biochemical analyses. Our findings suggest that GTP caps retain the filament helical structure and hydrolysis triggers filament stiffening upon disassembly...
February 23, 2017: Scientific Reports
keyword
keyword
8093
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"