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https://www.readbyqxmd.com/read/27890949/p16-immunostaining-as-a-predictor-of-anal-and-cervical-dysplasia-in-women-attending-a-sexually-transmitted-infection-clinic
#1
Deepika Pandhi, Kavita Bisherwal, Archana Singal, Kiran Guleria, Kiran Mishra
BACKGROUND: Carcinogenesis caused by human papillomavirus (HPV) leads to over-expression of p16 protein. p16 may act as a marker of HPV integration with host genome and serve as a surrogate marker of HPV oncogenesis. MATERIALS AND METHODS: A single center study of 75 women (35 HIV-positive and 40 HIV-negative women) was conducted. Anal and cervical specimens were obtained for cytology and p16 immunostaining. RESULTS: The sensitivity of p16 to diagnose anal and cervical dysplasia was 50% and 58...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27889035/anal-dysplasia
#2
REVIEW
Craig A Messick, Miguel A Rodriguez-Bigas
Anal dysplasia is a cytopathology term describing specific squamous cell morphology and represents a varying degree of benign changes. Often a source of confusion, the current iteration includes two types, low-grade and high-grade, and carries significant clinical implications. This article updates readers on the current definition of anal dysplasia, describes its incidence and prevalence, defines high-risk populations, and highlights diagnostics, treatment, and long-term management strategies for patients with anal dysplasia...
January 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/27845952/human-papillomavirus-as-a-cause-of-anal-cancer-and-the-role-of-screening
#3
Karien C M Gosens, Olivier Richel, Jan M Prins
PURPOSE OF REVIEW: Anal cancer is a serious health problem in HIV-positive men who have sex with men, and precursor lesions, anal intraepithelial neoplasia, are well defined. Given the similarities with cervical cancer, screening for and treatment of anal intraepithelial neoplasia might prevent anal cancer. Screening programmes should meet the Wilson and Jungner criteria. We used these criteria to evaluate the current body of evidence supporting a screening programme for anal dysplasia...
November 10, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27843448/could-total-colectomy-with-ileorectal-anastomosis-be-an-alternative-to-total-proctocolectomy-with-ileal-pouch-anal-anastomosis-in-selected-ulcerative-colitis-patients
#4
Francesco Tonelli, Carmela Di Martino, Francesco Giudici
Purpose. To evaluate ileorectal anastomosis (IRA) in selected ulcerative colitis patients. Methods. Early and late complications after IRA and IPAA were investigated. Bowel function and quality of life were assessed. Functional and QoL studies were performed as a matched pair analysis, comparing 98 patients who underwent IRA versus 98 patients who underwent IPAA. Results. In IRA group, 2 patients (1.6%) developed anastomotic l dysplasia (HGD) developed in 3 patients dysplasia (HGD) developed in 3 patients eakage, 1 patient (0...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27835758/association-of-cytologic-grade-of-anal-pap-smears-with-viral-loads-of-human-papillomavirus-types-16-18-and-52-detected-in-the-same-specimens-from-men-who-have-sex-with-men
#5
Utaiwan Utaipat, Sumalee Siriaunkgul, Taweewat Supindham, Pongpun Saokhieo, Butsayarat Chaidaeng, Antika Wongthanee, Jongkolnee Settakorn, Kornkanok Sukpan, Darin Ruanpeng, Natthapol Kosashunhanan, Nuntisa Chotirosniramit, Patcharaphan Sugandhavesa, Toshiyuki Miura, Suwat Chariyalertsak
BACKGROUND: Human papilloma virus (HPV) load has been linked to cellular abnormalities of the uterine cervix, and proposed as predictors of HPV persistence and progression of dysplasia to cervical cancer. However, the association of HPV viral load and anal dysplasia and cancer has not been as thoroughly investigated. OBJECTIVES: To examine the association of the viral loads of high-risk HPV types 16, 18, and 52, with the cytologic severity grading in anal-swab specimens of MSM with and without HIV-1 co-infection...
November 6, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27770248/a-trial-of-radiofrequency-ablation-for-anal-intraepithelial-neoplasia
#6
Robert N Goldstone, Shirin R Hasan, Steven Drury, Teresa M Darragh, Annemieke van Zante, Stephen E Goldstone
PURPOSE: Radiofrequency ablation (RFA) effectively treats esophageal high-grade dysplasia, but its efficacy in treating anal canal high-grade squamous intraepithelial lesions (HSILs) is unsubstantiated. This prospective study assessed the safety and efficacy of applying hemi-circumferential RFA to anal canal HSIL. METHODS: Twenty-one HIV-negative participants with HSIL occupying ≤ half the anal canal circumference were treated with hemi-circumferential anal canal RFA...
October 21, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27706233/dysregulation-of-autophagy-contributes-to-anal-carcinogenesis
#7
Evie H Carchman, Kristina A Matkowskyj, Louise Meske, Paul F Lambert
INTRODUCTION: Autophagy is an intracellular catabolic process that removes and recycles unnecessary/dysfunctional cellular components, contributing to cellular health and survival. Autophagy is a highly regulated cellular process that responds to several intracellular signals, many of which are deregulated by human papillomavirus (HPV) infection through the expression of HPV-encoded oncoproteins. This adaptive inhibitory response helps prevent viral clearance. A strong correlation remains between HPV infection and the development of squamous cell carcinoma (SCC) of the anus, particularly in HIV positive and other immunosuppressed patients...
2016: PloS One
https://www.readbyqxmd.com/read/27497040/emergency-total-proctocolectomy-in-an-uninsured-patient-with-familial-adenomatous-polyposis-syndrome-and-acute-lower-gastrointestinal-hemorrhage-in-a-community-hospital-a-case-report
#8
Rodolfo J Oviedo, Bruce M Dixon, Chase W Sofiak
INTRODUCTION: Rectal bleeding is the most common symptom of Familial Adenomatous Polyposis (FAP). This case investigates the efficacy of emergency surgery for FAP with total proctocolectomy end ileostomy for recurrent lower gastrointestinal (GI) hemorrhage in an uninsured patient in a 266-bed community hospital. The optimal treatment for FAP with acute lower GI hemorrhage and hemodynamic compromise unresponsive to conservative management is unclear. PRESENTATION OF CASE: A 41-year-old uninsured African American man with no past medical or family history presented to the emergency department with hematochezia lasting three days...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27463201/high-grade-dysplasia-in-anogenital-warts-of-hiv-positive-men
#9
Alexander Kreuter, Christos Siorokos, Frank Oellig, Steffi Silling, Herbert Pfister, Ulrike Wieland
Importance: Human papillomavirus (HPV)-induced anogenital lesions are very frequent in men who have sex with men (MSM) who are HIV-positive (HIV+). Anogenital warts (AGWs) are considered benign lesions caused by low-risk HPV-types, whereas anogenital dysplasias are potential cancer precursors associated with high-risk HPV-types. Both types of lesions can usually be distinguished clinically. Objective: To describe a case series of HIV+ MSM with typical AGW that harbored different grades of dysplasia...
July 27, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27450459/ulcerative-colitis-associated-with-nephrotic-syndrome-after-treatment-with-mesalazine-developed-into-rectal-carcinoma-a-case-study
#10
Shinichi Sameshima, Shinichiro Koketsu, Takashi Okuyama, Yawara Kubota, Yuko Ono, Tamaki Noie, Masatoshi Oya
BACKGROUND: Previous studies reported that nephrotic syndrome is associated with ulcerative colitis (UC) patients treated with mesalazine. Dysplasia associated with UC often develops into colorectal carcinoma. CASE PRESENTATION: A 17-year-old man was referred to our hospital, complaining of diarrhea and bloody stool. Total colonoscopy (TC) was performed and total-type UC was diagnosed. After treatment with mesalazine for 5 years, a low-grade dysplasia (LGD) was detected in the rectum by histological analysis of a biopsy sample...
2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27419814/anal-dysplasia-screening-and-treatment-in-a-southern-human-immunodeficiency-virus-clinic
#11
Wesley G Willeford, Luis Barroso, Jennifer Keller, Nora Fino, Laura H Bachmann
BACKGROUND: Persistent human papillomavirus infection in human immunodeficiency virus (HIV)-infected individuals has been strongly associated with anal squamous cell carcinoma. The incidence of anal squamous cell carcinoma continues to increase in this population despite advances in HIV therapy. There are few studies describing the prevalence of anal cancer precursors, treatment outcomes, and associated factors among HIV-infected populations in the southern United States. METHODS: A retrospective chart review was performed on 355 HIV-infected patients from a Southern HIV clinic who were 18 years or older and had received at least one anal Pap smear...
August 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27322045/uncertainty-abounds-in-the-world-of-anal-dysplasia-screening
#12
Wesley G Willeford, Laura H Bachmann
No abstract text is available yet for this article.
July 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27320416/treatment-of-anal-dysplasia-in-hiv-positive-men-who-have-sex-with-men-in-a-large-aids-reference-centre
#13
Nathalie Willems, Agnès Libois, Marcel Nkuize, Francesco Feoli, Marc Delforge, Stéphane DeWit
OBJECTIVES: Over the last few decades, incidence of anal cancer among HIV-positive men has been on the rise. In this context, programmes of screening and treatment of anal dysplasia which is a precursor of anal cancer have been developed. The aim of our study was to describe the efficiency, side effects and outcome of anal dysplasia treatment in a population of HIV-positive men who have sex with men (MSM). METHODS: We performed a retrospective study of HIV-positive MSM who received treatment for anal dysplasia between May 2010 and February 2014 in the Saint-Pierre University Hospital, Brussels...
June 16, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27297278/evaluation-of-cervical-and-anal-intraepithelial-neoplasia-in-women-attending-a-sexually-transmitted-infection-clinic
#14
Kavita Bisherwal, Deepika Pandhi, Archana Singal, Kiran Guleria, Kiran Mishra
BACKGROUND: The incidence of anal and cervical cancers and their precursors have increased in the past decades. Women with HIV and sexually transmitted infections are at a higher risk. Cervical human papilloma virus infection may serve as a reservoir and source of anal infection or vice versa. A higher incidence of anal cytological abnormality has been observed in patients with abnormal cervical cytology. OBJECTIVES: This cross sectional study was designed to estimate the prevalence and associations of anal and cervical cytological abnormalities in a cohort of sexually active women using Papanicolaou smears...
September 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27172856/risk-of-congenital-anomalies-after-exposure-to-asthma-medication-in-the-first-trimester-of-pregnancy-a-cohort-linkage-study
#15
E Garne, A Vinkel Hansen, J Morris, S Jordan, K Klungsøyr, A Engeland, D Tucker, D S Thayer, G I Davies, A-M Nybo Andersen, H Dolk
OBJECTIVE: To examine the effect of maternal exposure to asthma medications on the risk of congenital anomalies. DESIGN: Meta-analysis of aggregated data from three cohort studies. SETTING: Linkage between healthcare databases and EUROCAT congenital anomaly registries. POPULATION: 519 242 pregnancies in Norway (2004-2010), Wales (2000-2010) and Funen, Denmark (2000-2010). METHODS: Exposure defined as having at least one prescription for asthma medications issued (Wales) or dispensed (Norway, Denmark) from 91 days before to 91 days after the pregnancy start date...
September 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27144002/colonic-polyposis-in-a-15-year-old-boy-challenges-and-lessons-from-a-rural-resource-poor-area
#16
Nasser Kakembo, Phyllis Kisa, Tamara Fitzgerald, Doruk Ozgediz, John Sekabira
INTRODUCTION: Colorectal polyps usually present with rectal bleeding and are associated with increased risk of colorectal carcinoma. Evaluation and management in resource-poor areas present unique challenges. PRESENTATION OF CASE: This 15 year-old boy presented with 9 years of painless rectal bleeding and 2 years of a prolapsing rectal mass after passing stool. He had 3 nephews with similar symptoms. On clinical assessment and initial exam under anesthesia, an impression of a polyposis syndrome was made and a biopsy taken from the mass that revealed inflammatory polyps with no dysplasia...
May 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27141185/malignancies-in-a-renal-transplant-population-the-st-michael-s-hospital-experience
#17
R Saleeb, H Faragalla, G M Yousef, R Stewart, C J Streutker
INTRODUCTION: Previous publications have shown an increased incidence of various malignancies amongst renal transplant populations. The objective of this study was to analyze the rate and types of malignancies occurring in the St. Michael's Hospital renal transplant population and to determine whether our results were comparable to those previously published. METHODS: After approval by the hospital's research ethic board, review of the records and pathology of the 1584 patients in the renal transplant clinic database patients was performed...
April 2016: Urology Annals
https://www.readbyqxmd.com/read/27095188/evaluation-of-anal-cytology-and-dysplasia-in-women-with-a-history-of-lower-genital-tract-dysplasia-and-malignancy
#18
Beth Cronin, Amy Bregar, Christine Luis, Steven Schechter, Paul Disilvestro, Latha Pisharodi, C James Sung, Christina Raker, Melissa Clark, Katina Robison
OBJECTIVE: To compare the prevalence of abnormal anal cytology, high-risk anal HPV and biopsy proven anal dysplasia among women with a history of lower genital tract malignancy compared to those with dysplasia. METHODS: A prospective cohort study was performed from December 2012 to February 2014 at outpatient clinics at an academic medical center. Women with a history of high-grade cervical, vulvar, or vaginal dysplasia, or malignancy were recruited. Anal cytology and HPV genotyping were performed...
June 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27084730/the-genetic-landscape-and-clinical-implications-of-vertebral-anomalies-in-vacterl-association
#19
REVIEW
Yixin Chen, Zhenlei Liu, Jia Chen, Yuzhi Zuo, Sen Liu, Weisheng Chen, Gang Liu, Guixing Qiu, Philip F Giampietro, Nan Wu, Zhihong Wu
VACTERL association is a condition comprising multisystem congenital malformations, causing severe physical disability in affected individuals. It is typically defined by the concurrence of at least three of the following component features: vertebral anomalies (V), anal atresia (A), cardiac malformations (C), tracheo-oesophageal fistula (TE), renal dysplasia (R) and limb abnormalities (L). Vertebral anomaly is one of the most important and common defects that has been reported in approximately 60-95% of all VACTERL patients...
July 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27052528/-current-guidelines-in-dermatology-a-selection-of-clinically-relevant-recommendations
#20
REVIEW
A Nast, S Rosumeck, R Erdmann, C Dressler, R N Werner
Guidelines are systematically developed decision aids for specific medical conditions. The German Dermatological Society, together with the German Professional Association of Dermatologists, takes the lead in the development of the guidelines for dermatology in Germany. In addition to national guidelines, European and international guidelines also exist. In 2014 and 2015 German guidelines on the following topics were newly developed or updated: cutaneous larva migrans, anticoagulation during dermatosurgery, pemphigus vulgaris and bullous pemphigoids, Mohs surgery, anal dysplasia, and anal carcinoma in HIV-infected patients...
May 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
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