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https://www.readbyqxmd.com/read/29718243/the-impact-of-age-at-time-of-ileal-pouch-anal-anastomosis-on-short-and-long-term-outcomes-in-adults
#1
Nicholas P McKenna, Kellie L Mathis, John H Pemberton, Amy L Lightner
Background: There is limited knowledge on ileal pouch anal anastomosis (IPAA) function when performed on patients older than age 50 years. The aim of this study was to determine if surgery on those older than age 50 years impacts short-term complications or long-term function. Methods: A retrospective review of all patients undergoing IPAA for chronic ulcerative colitis at a single tertiary referral center between 2002 and 2013 was conducted. Short-term postoperative complications and long-term function and quality of life were analyzed according to age at pouch formation (age >50 vs age ≤50 years)...
April 26, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29601402/risk-factors-for-anal-dysplasia-in-transgender-women-a-retrospective-chart-review
#2
Lydia A Fein, Isabella Rosa Cunha, Brian Slomovitz, JoNell Potter
OBJECTIVE: The aim of the study was to assess risk factors for anal human papillomavirus (HPV) infection and anal dysplasia among a cohort of transgender women (TGW). METHODS: A retrospective chart review was conducted based on electronic medical records of TGW patients seen in the University of Miami Health System between 2010 and 2016. Outcome measures included risk factors of anal dysplasia, including HIV infection, receptive anal intercourse, and smoking history...
March 29, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29547439/high-grade-anal-intraepithelial-neoplasia-is-associated-with-hiv-1-rna-rectal-shedding-in-virologically-suppressed-men-who-have-sex-with-men
#3
Elena García-Payá, Marta Fernández, Sergio Padilla, José A García, Catalina Robledano, Victoria Ortiz DE LA Tabla, Félix Gutiérrez, Mar Masiá
OBJECTIVE: The protective effect of ART has not yet been definitively established in men who have sex with men (MSM). We aimed to characterize the factors associated with persistent HIV-1 RNA rectal shedding. METHODS: Prospective study including virologically-suppressed MSM from an HIV cohort. High-resolution anoscopy (HRA) was performed for screening of anal dysplasia, and rectal sampling for HIV-1 RNA quantification and sexually-transmitted infections (STIs) investigation through multiplex PCR...
March 15, 2018: AIDS
https://www.readbyqxmd.com/read/29545442/unusual-case-of-a-rectal-tumour
#4
Maryam Alfa-Wali, Samantha Muktar, Dimitrios Pissas, Ceri Slater
A 48-year-old man presented as an emergency with a 3-week history of rectal bleeding. Examination of his rectum revealed a circumferential tumour, 2 cm from the anal verge. An MRI scan reported a locally infiltrative mid-lower rectal tumour staged as T3d/T4 N2 MX. A colonoscopy revealed appearances of severe proctitis and biopsies did not show any evidence of dysplasia or malignancy. The patient was discussed at the regional colorectal cancer multidisciplinary team meeting with a management plan for neoadjuvant chemoradiotherapy following repeat biopsies, which were again negative for malignancy...
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29487947/simultaneous-induction-of-benign-condyloma-and-high-grade-anal-dysplasia-induced-by-low-risk-human-papillomavirus-type-42
#5
Alexander Kreuter, Martin Hufbauer, Steffi Silling, Frank Oellig, Baki Akgül, Ulrike Wieland
No abstract text is available yet for this article.
February 28, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29485187/imiquimod-anal-tampons-treatment-of-anal-intraepithelial-neoplasia
#6
LETTER
C Salas-Márquez, J B Repiso-Jiménez, L Padilla-España, M T Fernández-Morano, I M Escudero-Santos, F Rivas-Ruiz, M De Troya-Martín
No abstract text is available yet for this article.
February 27, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29465701/optimizing-screening-for-sexually-transmitted-infections-in-men-using-self-collected-swabs-a-systematic-review
#7
Nicholas Yared, Keith Horvath, Oluwaseun Fashanu, Ran Zhao, Jason Baker, Shalini Kulasingam
BACKGROUND: Sexually transmitted infection (STI) rates are increasing in the United States while funding for prevention and treatment programs has declined. Sample self-collection for STI testing in men may provide an acceptable, easy, rapid, and potentially cost-effective method for increasing diagnosis and treatment of STIs. METHODS: We conducted a systematic review of articles assessing self-collection of anal, oral, or genital swab samples among adult men for detection of STIs and/or human papillomavirus-related dysplasia...
May 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29456982/early-outcome-of-patient-with-ulcerative-colitis-who-received-high-dose-of-steroid-and-underwent-two-staged-total-proctocolectomy
#8
Hajar Khazraei, Alimohammad Bananzadeh, Seyed Vahid Hosseini
Background: Ulcerative colitis (UC) is an idiopathic inflammatory disorder. Currently, the final treatment is colectomy. The aim of this study was to investigate the outcomes of proctocolectomy in patients that used a high dose of prednisolone. Materials and Methods: Seventy-five patients presenting for surgical management of histopathologically proven UC. All patients were offered total proctocolectomy (TPC) with ileal pouch-anal anastomosis (IPAA). Patients were divided into two groups: low dose of steroids (Group A) and high dose of steroid (Group B) consumers...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29435953/role-of-noncommunicable-diseases-ncds-in-resource-limited-settings-rls
#9
REVIEW
Mosepele Mosepele, Elizabeth Botsile
PURPOSE OF REVIEW: As access to effective antiretroviral therapy (ART) expands globally, a decline in AIDS-related morbidity and mortality has been complicated by rising rates of noncommunicable diseases (NCDs). This review provides a brief description of NCDs and existing gaps on knowledge about NCDs among HIV-infected adults mostly in Africa. RECENT FINDINGS: Recent reports show that one in every five persons living with HIV has a chronic illness, predominantly diabetes and/or hypertension, depression, and most of these conditions are either not diagnosed or not being managed...
April 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29391089/abdominal-visceral-fat-area-and-chronic-pouchitis-after-ileal-pouch-anal-anastomosis
#10
Vivek Pandrangi, Daniel Mandel, Norman Gellada, Dionisio Mieses, Cindy Kallman, Karen Zaghiyan, Phillip Fleshner
Chronic pouchitis (CP) after ileal pouch-anal anastomosis is a significant clinical problem. Adipose tissues produce antiinflammatory cytokines and chemokines. We evaluated the association between abdominal visceral fat area (VFA) and CP. Patients with a preoperative CT evaluation were included. The diagnosis of CP was confirmed in all cases by endoscopy with afferent ileal limb intubation. Patients were allocated into groups of high VFA and low VFA. The study cohort of 52 patients had a median body mass index of 22 (range, 14-32)...
October 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29374678/multiple-types-of-human-papillomavirus-infection-and-anal-precancerous-lesions-in-hiv-infected-men-in-taiwan-a-cross-sectional-study
#11
Shu-Hsing Cheng, Kuo-Sheng Liao, Chi-Chao Wang, Chien-Yu Cheng, Fang-Yeh Chu
OBJECTIVES: This study aimed to assess the relationship between infection with multiple human papillomavirus (HPV) types and abnormal anal cytology in HIV-infected men. DESIGN: An observational, cross-sectional study. SETTING: A regional referral hospital in Taiwan. PARTICIPANTS: In total, 714 HIV-infected men were enrolled between March 2011 and June 2016. Thin preparation anal Pap smears were interpreted according to the 2001 Bethesda System...
January 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29360679/a-pilot-study-of-the-immunologic-virologic-and-pathologic-consequences-of-intra-anal-5-imiquimod-in-hiv-1-infected-men-with-high-grade-squamous-intraepithelial-lesions
#12
Ross D Cranston, Jonathan R Baker, Aaron Siegel, Rhonda M Brand, Laura Janocko, Ian McGowan
BACKGROUND: Imiquimod can be used to treat internal anal high-grade squamous intraepithelial lesions. In HIV-1-infected individuals there is a theoretical concern for increased HIV replication in anorectal tissue secondary to imiquimod-induced mucosal inflammation. OBJECTIVE: The purpose of this study was to assess local virologic, immunologic, and pathologic effects of imiquimod treatment in HIV-infected individuals. DESIGN: This was a pilot study at a single academic center...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29334527/transanal-minimally-invasive-anal-canal-polyp-resection
#13
Giovanni Dapri, Anny Cadenas Fabres, Olivier Nicod, Garces Duran Rodrigo, Vinciane Muls, Marc Van Gossum
Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are operative endoscopies that have been performed since a long time. Recently, an evolution of laparoscopy called transanal minimally invasive surgery began to be popularized, and it can be adopted in the face of difficult cases for EMR/ESD. In this video, a 36-year-old woman was submitted to transanal minimally invasive surgery resection, after unsuccessful ESD, for a 2-cm polyp located anteriorly in the anal canal, just beyond the pectineal line...
April 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29299373/anal-condylomas-predictors-of-recurrence-and-progression-to-high-grade-dysplasia-carcinoma-in-situ
#14
Armando Peixoto, Marco Silva, Rui Castro, Rosa Coelho, Alexandre Sarmento, Guilherme Macedo
No abstract text is available yet for this article.
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29232005/x-linked-vacterl-h-caused-by-deletion-of-exon-3-in-fancb-a-case-report
#15
Norikazu Watanabe, Seiji Tsutsumi, Yuki Miyano, Hidenori Sato, Satoru Nagase
No abstract text is available yet for this article.
December 12, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/29208455/high-prevalence-and-incidence-of-hpv-related-anal-cancer-precursor-lesions-in-hiv-positive-women-in-the-late-haart-era
#16
Carmen Hidalgo-Tenorio, Samantha E de Jesus, Javier Esquivias, Juan Pasquau
INTRODUCTION: Anal cancer is one of the most common non-AIDS defining malignancies, especially in men who have sex with men and women living with HIV (WLHIV). OBJECTIVES: To evaluate the prevalence and incidence of precursor lesions (high-grade squamous intraepithelial lesions [HSIL]) and anal cancer in our cohort of women and to compare them to cervical lesions; to calculate the percentage of patients that acquire and clear oncogenic genotypes (HR-HPV) in the anal canal; and to determine predictive factors for anal HPV infection...
December 2, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29204065/anal-cancer-and-anal-cancer-precursors-in-women-with-a-history-of-hpv-related-dysplasia-and-cancer
#17
Elizabeth A Stier, Elizabeth Y Chiao
The epidemiology of anal cancer in the U.S. has changed over the past 3 decades. During this period the incidence of anal cancer has increased among both men and women. Of note, women with a history of anogenital HPV infection are at higher risk than the general population for anal cancer. The increased risk ranged from increased incidence rate ratios ranging from 1.82 to 6.3 in women with a history of cervical cancer, to 4.2-16.4 in women with a history of prior cervical intraepithelial neoplasia 3 (CIN 3)...
June 2017: Seminars in Colon & Rectal Surgery
https://www.readbyqxmd.com/read/29173260/transanal-minimally-invasive-surgery-for-benign-large-rectal-polyps-and-early-malignant-rectal-cancers-experience-and-outcomes-from-the-first-canadian-centre-to-adopt-the-technique
#18
Antonio Caycedo-Marulanda, Henry Y Jiang, Erica L Kohtakangas
BACKGROUND: Transanal minimally invasive surgery (TAMIS) has emerged as a relatively new technique in treating early cancer and benign lesion of the rectum. The technique is likely to be widely adopted, surpassing other comparable techniques owing to its simple setup and cost-effectiveness. We assessed the outcomes of TAMIS at our centre. METHODS: We retrospectively reviewed prospectively collected data on 50 patients who underwent TAMIS for benign, malignant T1 or T2 cancers that were unfit for radical surgery over a 4-year period...
December 2017: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29168646/anal-cytology-histopathology-and-anoscopy-in-an-anal-dysplasia-screening-program-is-anal-cytology-enough
#19
Marco Silva, Armando Peixoto, José Alexandre Sarmento, Rosa Coelho, Guilherme Macedo
BACKGROUND AND AIM: The human papilloma virus is the leading cause of anal squamous cell carcinoma. Cytological screening may reduce the associated morbidity and mortality. The aim of the study was to estimate the agreement between anal cytological examination, histopathology and anoscopic visual impression. METHODS: A prospective study of patients who underwent anal dysplasia screening between 2011 and 2015, in a proctology clinic of a tertiary referral center...
February 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29135982/sting-expression-and-response-to-treatment-with-sting-ligands-in-premalignant-and-malignant-disease
#20
Jason R Baird, Zipeng Feng, Hong D Xiao, David Friedman, Ben Cottam, Bernard A Fox, Gwen Kramer, Rom S Leidner, R Bryan Bell, Kristina H Young, Marka R Crittenden, Michael J Gough
Human papilloma virus positive (HPV+) tumors represent a large proportion of anal, vulvar, vaginal, cervical and head and neck squamous carcinomas (HNSCC) and late stage invasive disease is thought to originate from a premalignant state. Cyclic dinucleotides that activate STimulator of INterferon Genes (STING) have been shown to cause rapid regression of a range of advanced tumors. We aimed to investigate STING ligands as a novel treatment for papilloma. We tested therapies in a spontaneous mouse model of papilloma of the face and anogenital region that histologically resembles human HPV-associated papilloma...
2017: PloS One
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