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Gallo and amyloid-dna

Caitlin N Spaulding, Karen W Dodson, Matthew R Chapman, Scott J Hultgren
Bacterial infection is associated with increased morbidity in patients with systematic lupus erythematosus. In a recent Immunity paper, Gallo et al. (2015) report that extracellular DNA is bound tightly by bacterial amyloid fibrils during biofilm formation and that amyloid/DNA composites are immune stimulators when injected into mice, leading to autoimmunity.
July 8, 2015: Cell Host & Microbe
Paul M Gallo, Glenn J Rapsinski, R Paul Wilson, Gertrude O Oppong, Uma Sriram, Mark Goulian, Bettina Buttaro, Roberto Caricchio, Stefania Gallucci, Çagla Tükel
Research on the human microbiome has established that commensal and pathogenic bacteria can influence obesity, cancer, and autoimmunity through mechanisms mostly unknown. We found that a component of bacterial biofilms, the amyloid protein curli, irreversibly formed fibers with bacterial DNA during biofilm formation. This interaction accelerated amyloid polymerization and created potent immunogenic complexes that activated immune cells, including dendritic cells, to produce cytokines such as type I interferons, which are pathogenic in systemic lupus erythematosus (SLE)...
June 16, 2015: Immunity
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