Esat Mahmut Kocaman, Onur Şenol, Serkan Yıldırım, Muhammed Atamanalp, Sinan Özcan, İsmail Bolat, Arzu Ucar, Metin Kiliçlioğlu, Veysel Parlak, Mehmet Takkac, Gonca Alak
This study focuses on the comparative metabolic profiling and effects of two steroid types: natural and synthetic, specifically 17α-methyl testosterone (17α-MT) at varying concentrations (1.5, 2, and 3 mg/kg) in rainbow trout ( Oncorhynchus mykiss ). Over a 75-day feeding trial, growth metrics such as feed efficiency, daily specific growth, live weight gain, total weight gain, and survival rate were systematically monitored every 15 days. At the end of the feeding trial, histopathology, immunohistochemistry, and metabolome analyses were performed in the high-concentration groups (3 mg/kg natural and 3 mg/kg synthetic), in which the lowest survival rate was determined...
February 20, 2024: Toxicology Mechanisms and Methods