Jeffrey R Brender, Julian C Assmann, Don E Farthing, Keita Saito, Shun Kishimoto, Kathrynne A Warrick, Natella Maglakelidze, Terri L Larus, Hellmut Merkle, Ronald E Gress, Murali C Krishna, Nataliya P Buxbaum
In vivo deuterated water (2 H2 O) labeling leads to deuterium (2 H) incorporation into biomolecules of proliferating cells and provides the basis for its use in cell kinetics research. We hypothesized that rapidly proliferating cancer cells would become preferentially labeled with 2 H and, therefore, could be visualized by deuterium magnetic resonance imaging (dMRI) following a brief period of in vivo systemic 2 H2 O administration. We initiated systemic 2 H2 O administration in two xenograft mouse models harboring either human colorectal, HT-29, or pancreatic, MiaPaCa-2, tumors and 2 H2 O level of ~ 8% in total body water (TBW)...
September 7, 2023: Scientific Reports